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Resumo Antecedentes A disfunção olfatória (DO) é uma manifestação frequente da doença do coronavírus 2019 (COVID-19). A apolipoproteína E (APOE) é uma proteína que interage com o receptor da enzima conversora de angiotensina, essencial para a entrada viral na célula. Publicações anteriores sugeriram um possível papel da APOE na gravidade da COVID-19. Até onde sabemos, nenhuma publicação encontrou associações significativas entre a gravidade dessa doença, DO e polimorfismos da APOE (E2, E3 e E4). Objetivo Analisar a epidemiologia da DO e sua relação com os polimorfismos do gene APOE em uma coorte de pacientes com COVID longa. Métodos Um estudo de coorte prospectiva com pacientes acompanhados em ambulatório neurológico pós-COVID, com DO sendo definida como uma redução subjetiva da função olfativa após a infecção e a DO persistente sendo definida quando a queixa durou mais de 3 meses após a resolução da infecção por COVID-19. Este estudo transversal é parte de uma pesquisa maior com dados anteriormente relatados, focando na performance cognitiva dos pacientes. Resultados Foram selecionados 221 pacientes para esse estudo, dos quais 186 haviam coletado amostras de sangue para genotipagem APOE. O grupo DO persistente foi mais jovem e apresentou menor taxa de internação na fase aguda da doença (p < 0,001). Além disso, a frequência do alelo E4 da APOE foi menor nesse grupo (p = 0,035). Este estudo avaliou a DO em uma população com COVID longa. Na literatura atual sobre essa doença, a anosmia está associada a melhores desfechos clínicos e o alelo E4 está associado a piores desfechos. Conclusão Nosso estudo acrescenta novas informações a essas correlações, sugerindo a APOE E4 como um fator de proteção para DO. (DO 201 COVID19. COVID19 19 . (COVID-19) (APOE angiotensina célula 19. COVID-19 sabemos E2, E2 (E2 E4. E4) longa pósCOVID, pósCOVID pós COVID, pós-COVID relatados 22 18 p 0,001. 0001 0,001 0 001 0,001) disso 0,035. 0035 0,035 035 0,035) correlações 20 COVID1 1 (COVID-19 COVID-1 (E 2 000 0,00 00 003 0,03 03 (COVID-1 COVID- 0,0 (COVID- 0, (COVID

Abstract Background Olfactory dysfunction (OD) represents a frequent manifestation of the coronavirus disease 2019 (COVID-19). Apolipoprotein E (APOE) is a protein that interacts with the angiotensin-converting enzyme receptor, essential for viral entry into the cell. Previous publications have suggested a possible role of APOE in COVID-19 severity. As far as we know, no publications found significant associations between this disease's severity, OD, and APOE polymorphisms (E2, E3, and E4). Objective To analyze the epidemiology of OD and its relationship with APOE polymorphisms in a cohort of Long-COVID patients. Methods We conducted a prospective cohort study with patients followed in a post-COVID neurological outpatient clinic, with OD being defined as a subjective reduction of olfactory function after infection, and persistent OD being defined when the complaint lasted more than 3 months after the COVID-19 infection resolution. This cross-sectional study is part of a large research with previously reported data focusing on the cognitive performance of our sample. Results The final sample comprised 221 patients, among whom 186 collected blood samples for APOE genotyping. The persistent OD group was younger and had a lower hospitalization rate during the acute phase of the disease (p < 0.001). Furthermore, the APOE variant E4 allele frequency was lower in this group (p = 0.035). This study evaluated OD in an outpatient population with COVID-19. In the current literature on this disease, anosmia is associated with better clinical outcomes and the E4 allele is associated with worse outcomes. Conclusion Our study provides new information to these correlations, suggesting APOE E4 as a protective factor for OD. (OD 201 COVID19. COVID19 COVID 19 . (COVID-19) (APOE angiotensinconverting angiotensin converting receptor cell COVID-1 severity know diseases s E2, E2 (E2 E3 E4. E4) LongCOVID Long postCOVID post clinic resolution crosssectional cross sectional 22 18 genotyping p 0.001. 0001 0.001 0 001 0.001) Furthermore 0.035. 0035 0.035 035 0.035) 19. correlations 20 COVID1 1 (COVID-19 COVID- (E 2 000 0.00 00 003 0.03 03 (COVID-1 0.0 (COVID- 0. (COVID

https://doi.org/10.1055/s-0044-1788272

Treatment of hyperprolactinemia in women: A Position Statement from the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and the Brazilian Society of Endocrinology and Metabolism (SBEM) women Febrasgo (Febrasgo SBEM (SBEM
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Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

; Rosa-e-Silva, Ana Carolina Japur de Sá

; Maciel, Gustavo Arantes Rosa

; Nogueira, Vania dos Santos Nunes

; Elias, Paula Condé Lamparelli

; Martins, Manoel

; Kasuki, Leandro

; Garmes, Heraldo Mendes

; Glezer, Andrea

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230504

Resumo: En | Texto: En | PDF: En

ABSTRACT Dopamine agonists are the first line of treatment for patients with symptomatic hyperprolactinemia due to prolactinomas and in those with idiopathic hyperprolactinemia. Treatment with these agents is effective in 80%-90% of the cases. Infertility treatment of patients with hyperprolactinemia is also carried out with dopamine agonists, aiming for the normalization of prolactin levels. The risk of symptomatic growth of prolactinomas during pregnancy is dependent on the tumor's size, duration of previous treatments, and prolactin levels. Notably, the corresponding risk is relatively low in cases of microprolactinomas (<5%). Remission of hyperprolactinemia occurs in about 30% of the patients after drug treatment and may also occur after pregnancy and menopause. The use of some drugs, such as antidepressants and antipsychotics, is a frequent cause of hyperprolactinemia, and managing this occurrence involves unique considerations. This position statement by the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and Brazilian Society of Endocrinology and Metabolism (SBEM) addresses the recommendations for measurement of serum prolactin levels and the investigations of symptomatic and asymptomatic hyperprolactinemia and drug-induced hyperprolactinemia in women. 80%90% 8090 80% 90% 80 90 80%-90 tumors tumor s size treatments Notably <5%. 5 <5% . (<5%) 30 menopause drugs antipsychotics considerations Febrasgo (Febrasgo SBEM (SBEM druginduced induced women 80%90 809 8 9 80%-9 <5 (<5% 3 80%9 80%- < (<5 (< (

https://doi.org/10.20945/2359-4292-2023-0504

Diagnosis of hyperprolactinemia in women: A Position Statement from the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and the Brazilian Society of Endocrinology and Metabolism (SBEM) women Febrasgo (Febrasgo SBEM (SBEM
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Glezer, Andrea

; Garmes, Heraldo Mendes

; Kasuki, Leandro

; Martins, Manoel

; Elias, Paula Condé Lamparelli

; Nogueira, Vania dos Santos Nunes

; Rosa-e-Silva, Ana Carolina Japur de Sá

; Maciel, Gustavo Arantes Rosa

; Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230502

Resumo: En | Texto: En | PDF: En

ABSTRACT Hyperprolactinemia is a frequent cause of menstrual irregularity, galactorrhea, hypogonadism, and infertility. The most common etiologies of hyperprolactinemia can be classified as physiological, pharmacological, and pathological. Among pathological conditions, it is essential to distinguish prolactinomas from other tumors and pituitary lesions presenting with hyperprolactinemia due to pituitary stalk disconnection. Proper investigation considering clinical data, laboratory tests, and, if necessary, imaging evaluation, is important to identify the correct cause of hyperprolactinemia and manage the patient properly. This position statement by the Brazilian Federation of Gynecology and Obstetrics Associations (Febrasgo) and Brazilian Society of Endocrinology and Metabolism (SBEM) addresses the recommendations for measurement of serum prolactin levels and the investigations of symptomatic and asymptomatic hyperprolactinemia and medication-induced hyperprolactinemia in women. irregularity galactorrhea hypogonadism infertility physiological pharmacological conditions disconnection data tests necessary evaluation properly Febrasgo (Febrasgo SBEM (SBEM medicationinduced medication induced women

https://doi.org/10.20945/2359-4292-2023-0502

Hyperprolactinemia in women: treatment women
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Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

; Rosa e Silva, Ana Carolina Japur

; Maciel, Gustavo Arantes Rosa

; dos Santos Nunes Nogueira, Vania

; Elias, Paula Condé Lamparelli

; Martins, Manoel

; Kasuki, Leandro

; Garmes, Heraldo Mendes

; Glezer, Andrea

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-FPS05

Resumo: En | Texto: En | PDF: En

https://doi.org/10.61622/rbgo/2024fps05

Hyperprolactinemia in women: diagnostic approach women
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Glezer, Andrea

; Garmes, Heraldo Mendes

; Kasuki, Leandro

; Martins, Manoel

; Elias, Paula Condé Lamparelli

; Nogueira, Vania dos Santos Nunes

; Rosa-e-Silva, Ana Carolina Japur de Sá

; Maciel, Gustavo Arantes Rosa

; Benetti-Pinto, Cristina Laguna

; Nácul, Andrea Prestes

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-FPS04

Resumo: En | Texto: En | PDF: En

https://doi.org/10.61622/rbgo/2024fps04

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and prognosis after aneurysmal subarachnoid hemorrhage: a cohort study Neutrophiltolymphocyte Neutrophil to lymphocyte platelettolymphocyte platelet hemorrhage
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Oliveira, Adilson Jose Manuel de

; Rabelo, Nicollas Nunes

; Telles, João Paulo Mota

; Solla, Davi Jorge Fontoura

; Coelho, Antonio Carlos Samaia da Silva

; Barbosa, Guilherme Bitencourt

; Barbato, Natália Camargo

; Yoshikawa, Marcia Harumy

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Arquivos de Neuro-Psiquiatria

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Jun 2023, Volume 81 Nº 6 Páginas 515 - 523

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Subarachnoid hemorrhage (SAH) prognosis remains poor. Vasospasm mechanism might be associated with inflammation. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been studied as inflammation markers and prognostic predictors. Objective We aimed to investigate NLR and PLR in admission as predictors of angiographic vasospasm and functional outcome at 6 months. Methods This cohort study included consecutive aneurysmal SAH patients admitted to a tertiary center. Complete blood count was recorded at admission before treatment. White blood cell count, neutrophil count, lymphocyte count, platelet count, NLR, and PLR were collected as independent variables. Vasospasm occurrence-modified Rankin scale (mRS), Glasgow outcome scale (GOS), and Hunt-Hess score at admission and at 6 months were recorded as dependent variables. Multivariable logistic regression models were used to adjust for potential confounding and to assess the independent prognostic value of NLR and PLR at admission. Results A total of 74.1% of the patients were female, with mean age of 55.6 ± 12.4 years. At admission, the median Hunt-Hess score was 2 (interquartile range [IQR] 1), and the median mFisher was 3 (IQR 1). Microsurgical clipping was the treatment for 66.2% of the patients. Angiographic vasospasm incidence was 16.5%. At 6 months, the median GOS was 4 (IQR 0.75), and the median mRS was 3 (IQR 1.5). Twenty-one patients (15.1%) died. Neutrophil-to-lymphocyte ratio and PLR levels did not differ between favorable and unfavorable (mRS > 2 or GOS < 4) functional outcomes. No variables were significantly associated with angiographic vasospasm. Conclusion Admission NLR and PLR presented no value for prediction of functional outcome or angiographic vasospasm risk. Further research is needed in this field. (SAH poor Neutrophiltolymphocyte Neutrophil (NLR platelettolymphocyte (PLR center occurrencemodified occurrence modified mRS, , (mRS) GOS, (GOS) HuntHess Hunt Hess 741 74 1 74.1 female 556 55 55. 124 12 12. years interquartile IQR [IQR 1, 1) 1. . 662 66 66.2 165 16 5 16.5% 0.75, 075 0.75 0 75 0.75) 1.5. 15 1.5 1.5) Twentyone Twenty one 15.1% 151 (15.1% died outcomes risk field (GOS 7 74. 66. 16.5 07 0.7 15.1 (15.1 16. 0. 15. (15. (15 (1 (

Resumo Antecedentes O prognóstico da hemorragia subaracnoidea (HSA) permanece ruim. Vasoespasmo pode estar associado à inflamação. Razões neutrófilo-linfócito (NLR) e plaqueta-linfócito (PLR) têm sido estudadas como marcadores de inflamação e prognóstico. Objetivo Investigar NLR e PLR na admissão como preditores de vasoespasmo angiográfico e desfecho aos 6 meses. Métodos Este estudo de coorte incluiu pacientes consecutivos com HSA aneurismática de um centro terciário. Contagem de leucócitos, neutrófilos, linfócitos e plaquetas, proporção de neutrófilos para linfócitos e de plaquetas para linfócitos foram coletados como variáveis independentes. Ocorrência de vasoespasmo, escala de Rankin modificada, escala de desfecho de Glasgow e o escore de Hunt-Hess na admissão e 6 meses após a mesma foram registradas como variáveis dependentes. Modelos de regressão logística multivariável foram usados para ajustar potenciais fatores de confusão e avaliar valor prognóstico independente de NLR e PLR. Resultados Um total de 74,1% pacientes eram do sexo feminino, com idade média de 55,6 ± 12,4 anos. Na admissão, a pontuação média de Hunt-Hess foi de 2 (IQR 1) e a mediana de mFisher foi de 3 (IQR 1). Clipagem microcirúrgica foi o tratamento escolhido para 66,2% dos pacientes. A incidência de vasoespasmo angiográfico foi de 16,5%. Aos 6 meses, a escala de desfecho de Glasgow mediana era 4 (IQR 0,75) e a escala de Rankin modificada mediana era 3 (IQR 1,5). Vinte e um pacientes (15,1%) morreram. Os níveis de NLR e PLR não diferiram entre resultados funcionais favoráveis e desfavoráveis (mRS > 2 ou GOS < 4). Nenhuma variável foi significativamente associada ao vasoespasmo angiográfico. Conclusão Razão neutrófilo-linfócito e a PLR não apresentaram valor preditivo de desfecho funcional ou risco de vasoespasmo angiográfico. Mais pesquisas são necessárias neste campo. (HSA ruim neutrófilolinfócito neutrófilo linfócito (NLR plaquetalinfócito plaqueta (PLR terciário leucócitos independentes HuntHess Hunt Hess dependentes 741 74 1 74,1 feminino 556 55 55, 124 12 12, anos IQR 1. . 662 66 66,2 165 16 5 16,5% 0,75 075 0 75 1,5. 15 1,5 1,5) 15,1% 151 (15,1% morreram mRS 4. 4) campo 7 74, 66, 16,5 0,7 07 1, 15,1 (15,1 16, 0, 15, (15, (15 (1 (

https://doi.org/10.1055/s-0043-1768662

Úlcera de Marjolin: a importância do diagnóstico e excisão precoces Marjolin
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RODOVALHO, NATHÁLIA NUNES

; DUARTE, LARISSA ROCHA ALÍPIO

; GUIMARÃES, ISADORA SENNA

; SOUZA, INGRID HOVSEPIAN DE

; MAGALHÃES, LUANA OLIVEIRA

; SILVA NETO, MANOEL PEREIRA DA

Revista Brasileira de Cirurgia Plástica

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2023, Volume 38 Nº 2 elocation e0654

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: Marjolin’s ulcer is a rare disease characterized by the malignancy of chronic wounds that present healing disorders, often due to chronic irritation and repetitive trauma in this area. The diagnosis is made mainly through clinical history and histopathological examination. The differential diagnoses of other diseases that course with ulcers must always be researched and ruled out. Method: The present work presents a bibliographic review to elucidate the subject’s relevance for medical students, physicians and nurses, to assist in early diagnosis. Results: Nine observational studies were selected to compose the discussion. Conclusion: The most effective treatment for this condition is surgery, and lymph node dissection is suggested in some cases. Chemotherapy has not shown satisfactory results, while radiotherapy is used in selected cases. Given the rapid evolution, tissue damage, and worse prognosis, diagnosis, and excision should be performed early for a better clinical outcome. Introduction Marjolins Marjolin s disorders area examination out Method subjects subject students nurses Results discussion Conclusion surgery cases results evolution damage prognosis outcome

RESUMO Introdução: A úlcera de Marjolin é uma doença rara, caracterizada pela malignização de feridas crônicas que apresentaram distúrbios cicatriciais, muitas vezes devido à irritação crônica e a traumas repetitivos nesta área. O diagnóstico é realizado sobretudo através da história clínica e de exame histopatológico. Os diagnósticos diferenciais de outras doenças que curs am com úlceras devem sempre ser pesquisados e afastados. Método: O presente trabalho apresenta uma revisão bibliográfica, a fim de elucidar a relevância do tema para acadêmicos de medicina, médicos e enfermeiros, com o propósito de auxiliar no diagnóstico precoce. Resultados: Foram selecionados 9 estudos observacionais para compor a discussão. Conclusão: O tratamento mais eficaz desta condição é o cirúrgico, e o esvaziamento linfonodal é sugerido em alguns casos. A quimioterapia não demonstrou resultados satisfatórios, enquanto a radioterapia é utilizada em casos selecionados. O diagnóstico e a excisão devem ser feitos precocemente para melhor desfecho clínico, visto a rapidez da evolução, o prejuízo tecidual e pior prognóstico. Introdução rara cicatriciais área histopatológico afastados Método bibliográfica medicina enfermeiros precoce Resultados discussão Conclusão cirúrgico satisfatórios clínico evolução prognóstico

https://doi.org/10.5935/2177-1235.2023rbcp0654-pt

Role of temporary arterial occlusion in subarachnoid hemorrhage outcomes: a prospective cohort study outcomes
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Yoshikawa, Marcia Harumy

; Rabelo, Nícollas Nunes

; Telles, João Paulo Mota

; Pipek, Leonardo Zumerkorn

; Barbosa, Guilherme Bitencourt

; Barbato, Natália Camargo

; Coelho, Antônio Carlos Samaia da Silva

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e387923

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: Temporary arterial occlusion (TAO) is a widespread practice in the surgical treatment of intracranial aneurysms. This study aimed to investigate TAO’s role during ruptured aneurysm clipping as an independent prognostic factor on short- and long-term outcomes. Methods: This prospective cohort included 180 patients with ruptured intracranial aneurysms and an indication of microsurgical treatment. Patients who died in the first 12 hours after admission were excluded. Results: TAO was associated with intraoperative rupture (IOR) (odds ratio – OR = 10.54; 95% confidence interval – 95%CI 4.72–23.55; p < 0.001) and surgical complications (OR = 2.14; 95%CI 1.11–4.07; p = 0.01). The group with TAO and IOR had no significant difference in clinical (p = 0.06) and surgical (p = 0.94) complications compared to the group that had TAO, but no IOR. Among the 111 patients followed six months after treatment, IOR, number of occlusions, and total time of occlusion were not associated with Glasgow Outcome Scale (GOS) in the follow-up (respectively, p = 0.18, p = 0.30, and p = 0.73). Among patients who underwent TAO, IOR was also not associated with GOS in the follow-up (p = 0.29). Conclusions: TAO was associated with IOR and surgical complications, being the latter independent of IOR occurrence. In long-term analysis, neither TAO nor IOR were associated with poor clinical outcomes. Purpose (TAO TAOs s short longterm long term outcomes Methods 18 1 excluded Results (IOR odds 10.54 1054 10 54 95 95CI CI 4.72–23.55 4722355 4 72 23 55 0.001 0001 0 001 2.14 214 2 14 1.11–4.07 111407 11 07 0.01. 0.01 . 01 0.01) 0.06 006 06 0.94 094 94 occlusions (GOS followup follow up respectively, respectively (respectively 018 0.18 030 30 0.30 0.73. 073 0.73 73 0.73) 0.29. 029 0.29 29 0.29) Conclusions occurrence analysis 10.5 105 5 9 4.72–23.5 472235 7 0.00 000 00 2.1 21 1.11–4.0 11140 0.0 0.9 09 0.1 03 3 0.3 0.7 02 0.2 10. 4.72–23. 47223 2. 1.11–4. 1114 0. 4.72–23 4722 1.11–4 4.72–2 472 1.11– 4.72– 47 1.11 4.72 1.1 4.7 1. 4.

https://doi.org/10.1590/acb387923

Microsurgery versus embolization: different risk factors for short- and longterm outcomes of patients with ruptured aneurysms
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Yoshikawa, Marcia Harumy

; Rabelo, Nícollas Nunes

; Telles, João Paulo Mota

; Barbosa, Guilherme Bitencourt

; Barbato, Natália Camargo

; Coelho, Antônio Carlos Samaia da Silva

; Pipek, Leonardo Zumerkorn

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Acta Cirúrgica Brasileira

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2022, Volume 37 Nº 8 elocation e370806

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: To evaluate the risk factors for poor outcomes after surgical and endovascular treatment of aneurysmal subarachnoid hemorrhage (aSAH). Methods: Patients with ≥ 18-years of age and aSAH were included, while patients who died within 12 h of admission or lost follow-up were excluded. All participants underwent standardized clinical and radiological assessment on admission and were reassessed at discharge and at 6-months follow-up using the Glasgow Outcome Scale (GOS). Results: Death at discharge was associated with female gender, anterior communication artery (ACoA) aneurysm location and presence of atherosclerotic plaque in the surgical group, and with age in the endovascular group. Both groups had clinical condition on follow-up associated with mFisher score on admission and hypertension. GOS on follow-up was also associated with presence of atherosclerotic plaque and multiple aneurysms in surgical group, and with age in endovascular group. Conclusions: Subjects treated surgically are prone to unfavorable outcomes if atherosclerotic plaques and multiple aneurysms are present. In patients with endovascular treatment, age was the main predictor of clinical outcome.

https://doi.org/10.1590/acb370806

10.

Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?
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Rabelo, Nícollas Nunes

; Pipek, Leonardo Zumerkorn

; Nascimento, Rafaela Farias Vidigal

; Telles, João Paulo Mota

; Barbato, Natalia Camargo

; Coelho, Antônio Carlos Samaia da Silva

; Barbosa, Guilherme Bitencourt

; Yoshikawa, Marcia Harumy

; Teixeira, Manoel Jacobsen

; Figueiredo, Eberval Gadelha

Acta Cirúrgica Brasileira

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2022, Volume 37 Nº 1 elocation e370107

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes. Methods: This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Linear and logistic regressions were used to analyze the data. Modified Rankin scale (mRS) was used to assess outcome. Results: Creatinine level was not directly related to aneurysm outcome nor aneurysm rupture (p > 0.05). However, patients with a glomerular filtration rate (GFR) lower than 72.50 mL·min–1 had an odds ratio (OR) of 3.049 (p = 0.006) for worse outcome. Similarly, aneurysm rupture had an OR of 2.957 (p = 0.014) for worse outcomes. Stepwise selection model selected 4 variables for outcomes prediction: serum creatinine, sex, hypertension and treatment. Hypertensive patients had, on average, an increase in 0.588 in mRS (p = 0.022), while treatment with microsurgery had a decrease in 0.555 (p = 0.038). Conclusions: Patients with higher GFR had better outcomes after 6 months. Patients with higher GFR had better outcomes after 6 months. Creatinine presented an indirect role in GFR values and should be included in models for outcome prediction.

https://doi.org/10.1590/acb370107

11.

New records of dragonflies and damselflies (Insecta: Odonata) from Amapá state, Brazil
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Garcia Junior, Manoel Daltro Nunes

; Damasceno, Monique Telcia dos Santos

; Martins, Maria Jeovana Lima

; Costa, Tiago Silva da

; Ferreira, Ricardo Marcelo dos Anjos

; Souto, Raimundo Nonato Picanço

Biota Neotropica

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2021, Volume 21 Nº 1 elocation e20201074

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: A ordem Odonata compreende um dos maiores grupos de insetos aquáticos, mundialmente são descritas 7.000 espécies, sendo que, para o Brasil estão registradas aproximadamente 860 espécies, algo em torno de 14% da fauna global conhecida até o momento. No entanto, ainda existem grandes lacunas no conhecimento da odonatofauna em muitas áreas do Brasil. Este estudo tem como objetivo apresentar o resultado do levantamento de espécies de Odonata amostradas em três municípios do estado Amapá. O estado se encontra na região norte do país, inserido no Bioma amazônico. As capturas de Odonata foram realizadas entre os meses de janeiro e dezembro de 2018, sendo amostrados 472 espécimes pertencentes a sete famílias, 36 gêneros e 53 espécies. No total, 27 das espécies encontradas durante o estudo correspondem a novos registros para o estado do Amapá. Devido à falta de informação sobre a diversidade da ordem Odonata no Amapá, a lista de espécies apresentada deve servir de aporte para novos estudos contribuindo com o conhecimento da ordem no estado.

Abstract: The Odonata Order comprises one of the largest groups of aquatic insects, 7,000 species are described worldwide, with approximately 860 species registered in Brazil, around 14% of the global fauna known to date. However, there are still great gaps in the knowledge of Odonata fauna in many areas of Brazil. This study aims to present the results of the survey of Odonata species sampled in three counties in the state of Amapá. The state is located in the north of the country, inserted in the Amazon Biome. Odonata were caught between January and December 2018, with 472 specimens being sampled, belonging to seven families, 36 genera and 53 species. In total, 27 of the species found during the study correspond to new records for the state of Amapá. Due to the lack of information on the diversity of the Odonata order in Amapá, the list of species presented should serve as input for new studies contributing to the knowledge of the order in the state.

https://doi.org/10.1590/1676-0611-bn-2020-1074 941 downloads

12.

The Current State of Obstetric Nursing in Brazil
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Oliveira, Ana Paula Cavalcante de

; Ventura, Carla Aparecida Arena

; Galante, Mariana Lopes

; Padilla, Mónica

; Cunha, Anna

; Mendes, Isabel Amelia Costa

; Souza, Kleyde Ventura de

; Silva, Manoel Carlos Neri da

; Pinheiro, Mayra Isabel Correia

; Ramalho, Nádia Mattos

; Acioli, Sonia

; Azevedo, Vinícius Nunes

Revista Latino-Americana de Enfermagem

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2021, Volume 29 elocation e3510

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/1518-8345.0000.3510

13.

Physicochemical quality of brown soybean preserve in function of maceration time and ascorbic acid
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TASSI, Adriana Luiza Wain

; BENTO, Juliana Aparecida Correia

; CALIARI, Márcio

; SILVA, Vera Sônia Nunes da

; PACHECO, Maria Teresa Bertoldo

; VERA, Rosângela

; SOARES JÚNIOR, Manoel Soares

Food Science and Technology

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Jun 2020, Volume 40 Páginas 250 - 257

Resumo: En | Texto: En | PDF: En

Abstract The aim of the present study was to evaluate the physical and chemical quality of the brown soybean preserve in function of the ascorbic acid concentration and the maceration time, and also to evaluate the chemical composition, microbiological hazard, and acceptability of the best preserve, in addition verify its technological, nutritional, functional and sensory viability. The hardness of the grain ranged between 8.6 and 23N and was significantly affected by the maceration time. The ascorbic acid concentration influenced antioxidant activity (ranged between 4.3 and 183.8 mg100g-1) and total phenolic compounds (ranged between 176.4 and 466.2 mg100g-1). The best brown soybean preserve was obtained with a maceration time of 23 min and an ascorbic acid concentration of 0.15 g100g-1 . This shows high nutritional value and essential amino acid content, absence of trypsin inhibitor and microbiological risk, and also sensory acceptance. Therefore, the brown soybean preserve is viable, and its consumption is recommended.

https://doi.org/10.1590/fst.09618 628 downloads

14.

Medidas de distanciamento social no controle da pandemia de COVID-19: potenciais impactos e desafios no Brasil
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Aquino, Estela M. L.

; Silveira, Ismael Henrique

; Pescarini, Julia Moreira

; Aquino, Rosana

; Souza-Filho, Jaime Almeida de

; Rocha, Aline dos Santos

; Ferreira, Andrea

; Victor, Audêncio

; Teixeira, Camila

; Machado, Daiane Borges

; Paixão, Enny

; Alves, Flávia Jôse Oliveira

; Pilecco, Flávia

; Menezes, Greice

; Gabrielli, Ligia

; Leite, Luciana

; Almeida, Maria da Conceição Chagas de

; Ortelan, Naiá

; Fernandes, Qeren Hapuk R. Ferreira

; Ortiz, Renzo Joel Flores

; Palmeira, Raquel Nunes

; Pinto Junior, Elzo Pereira

; Aragão, Erika

; Souza, Luis Eugenio Portela Fernandes de

; Barral Netto, Manoel

; Teixeira, Maria Glória

; Barreto, Mauricio Lima

; Ichihara, Maria Yury

; Lima, Raíza Tourinho dos Reis Silva

Ciência & Saúde Coletiva

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Jun 2020, Volume 25 Supl. 1 Páginas 2423 - 2446

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A pandemia de COVID-19 tem desafiado pesquisadores e gestores a encontrar medidas de saúde pública que evitem o colapso dos sistemas de saúde e reduzam os óbitos. Esta revisão narrativa buscou sistematizar as evidências sobre o impacto das medidas de distanciamento social na epidemia de COVID-19 e discutir sua implementação no Brasil. Foram triados artigos sobre o efeito do distanciamento social na COVID-19 no PubMed, medRXiv e bioRvix, e analisados atos do poder público nos níveis federal e estadual para sumarizar as estratégias implementadas no Brasil. Os achados sugerem que o distanciamento social adotado por população é efetivo, especialmente quando combinado ao isolamento de casos e à quarentena dos contatos. Recomenda-se a implementação de medidas de distanciamento social e de políticas de proteção social para garantir a sustentabilidade dessas medidas. Para o controle da COVID-19 no Brasil, é imprescindível que essas medidas estejam aliadas ao fortalecimento do sistema de vigilância nos três níveis do SUS, que inclui a avaliação e uso de indicadores adicionais para monitorar a evolução da pandemia e o efeito das medidas de controle, a ampliação da capacidade de testagem, e divulgação ampla e transparente das notificações e de testagem desagregadas.

Abstract The COVID-19 pandemic has challenged researchers and policy makers to identify public safety measures forpreventing the collapse of healthcare systems and reducingdeaths. This narrative review summarizes the available evidence on the impact of social distancing measures on the epidemic and discusses the implementation of these measures in Brazil. Articles on the effect of social distancing on COVID-19 were selected from the PubMed, medRXiv and bioRvix databases. Federal and state legislation was analyzed to summarize the strategies implemented in Brazil. Social distancing measures adopted by the population appear effective, particularly when implemented in conjunction with the isolation of cases and quarantining of contacts. Therefore, social distancing measures, and social protection policies to guarantee the sustainability of these measures, should be implemented. To control COVID-19 in Brazil, it is also crucial that epidemiological monitoring is strengthened at all three levels of the Brazilian National Health System (SUS). This includes evaluating and usingsupplementary indicators to monitor the progression of the pandemic and the effect of the control measures, increasing testing capacity, and making disaggregated notificationsand testing resultstransparentand broadly available.

https://doi.org/10.1590/1413-81232020256.1.10502020 73073 downloads

15.

Medidas de distanciamento social no controle da pandemia de COVID-19: potenciais impactos e desafios no Brasil
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Aquino, Estela M. L.

; Silveira, Ismael Henrique

; Pescarini, Julia Moreira

; Aquino, Rosana

; Souza-Filho, Jaime Almeida de

; Rocha, Aline dos Santos

; Ferreira, Andrea

; Victor, Audêncio

; Teixeira, Camila

; Machado, Daiane Borges

; Paixão, Enny

; Alves, Flávia Jôse Oliveira

; Pilecco, Flávia

; Menezes, Greice

; Gabrielli, Ligia

; Leite, Luciana

; Almeida, Maria da Conceição Chagas de

; Ortelan, Naiá

; Fernandes, Qeren Hapuk R. Ferreira

; Ortiz, Renzo Joel Flores

; Palmeira, Raquel Nunes

; Pinto Junior, Elzo Pereira

; Aragão, Erika

; Souza, Luis Eugenio Portela Fernandes de

; Barral Netto, Manoel

; Teixeira, Maria Glória

; Barreto, Mauricio Lima

; Ichihara, Maria Yury

; Lima, Raíza Tourinho dos Reis Silva

Ciência & Saúde Coletiva

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2020, Volume 25 Supl. 1 Páginas 2423 - 2446

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232020256.1.10502020

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