RESUMO A busca por novas tecnologias capazes de proporcionar benefícios para uma alimentação saudável tem sido meta mundial. A presença de alimentos ricos em carotenoides pode ser fundamental para prevenir sérios problemas de saúde. Aliar alimentos com altos teores de carotenoides e acessíveis para a maior parte da população é fundamental. A alface (Lactuca sativa L.) se apresenta como uma espécie adequada para investir em pesquisas com biofortificação a partir de melhoramento genético. Assim, o objetivo com este estudo foi selecionar híbridos de alface visando à obtenção de populações com potencial agronômico e biofortificadas para carotenoides. Dez linhagens de alface cadastradas no Software “BG α Biofort” foram utilizadas nas hibridações. Os cruzamentos para obtenção dos híbridos foram planejados envolvendo duas linhagens ricas em pelo menos um dos pigmentos (clorofila e carotenoides) sendo obtidos 24 híbridos experimentais. Foram avaliados 37 genótipos (linhagens, híbridos e cultivares comercias) em delineamento em blocos casualizados quanto as variáveis agronômicas e teores de clorofila e carotenoides. Foi verificado que os híbridos 12 (UFU-189#3#4#1 × UFU MC BIOFORT 2) e 25 (UFU66#4#2 × UFU-189#3#4#1) possuem potencial para obtenção de populações de duplo propósito (produtividade e biofortificada para carotenoide). O híbrido 27 (UFU66#4#2 × UFU MC BIOFORT1) foi o que apresentou maior equilíbrio para pigmentos. Sugere-se a obtenção de populações F2 dos híbridos 12, 25 e 27 visando a obtenção de novas cultivares de alfaces biofortificadas vermelhas e verdes, para os segmentos de alface crespa, americana, mini e romana. mundial saúde Lactuca L. L genético Assim BG Biofort hibridações 2 experimentais 3 linhagens, (linhagens comercias 1 UFU189#3#4#1 UFU189341 189#3#4#1 189 4 (UFU-189#3#4# UFU66#4#2 UFU6642 UFU66 (UFU66#4# UFU-189#3#4#1 produtividade carotenoide. carotenoide . carotenoide) BIOFORT1 Sugerese Sugere F verdes crespa americana romana UFU189 UFU189#3#4# UFU18934 189341 189#3#4# 18 (UFU-189#3#4 UFU66#4# UFU664 UFU6 (UFU66#4 UFU-189#3#4# UFU18 UFU189#3#4 UFU1893 18934 189#3#4 (UFU-189#3# UFU66#4 (UFU66# UFU-189#3#4 UFU1 UFU189#3# 1893 189#3# (UFU-189#3 UFU66# (UFU66 UFU-189#3# UFU189#3 189#3 (UFU-189# (UFU6 UFU-189#3 UFU189# 189# (UFU-189 (UFU UFU-189# (UFU-18 UFU-189 (UFU-1 UFU-18 (UFU- UFU-1 UFU-

ABSTRACT The search for new technologies capable of providing benefits to healthy eating is a global goal. The consumption of foods rich in carotenoids can prevent serious health problems. Thus, the availability of foods high in carotenoids that are accessible to the majority of the population is essential. Lettuce (Lactuca sativa L.) is a suitable species for biofortification research based on genetic improvements. In this study, we aimed to select and obtain hybrid lettuce populations with high agronomic potential and biofortified carotenoid content. Ten lettuce lines registered in the “BG α Biofort” software were selected for hybridization. The crosses used to obtain the hybrids involved two strains rich in at least one of the pigments (chlorophyll and carotenoids), and 24 experimental hybrids were obtained. A total of 37 genotypes (strains, hybrids, and commercial cultivars) were evaluated using a randomized block design for agronomic variables and chlorophyll and carotenoid content. Hybrids 12 (UFU-189#3#4#1 × UFU MC BIOFORT 2) and 25 (UFU66#4#2 × UFU-189#3#4#1) had the potential to produce dual-purpose populations (yield and carotenoid biofortification). Hybrid 27 (UFU66#4#2 × UFU MC BIOFORT1) exhibited the best pigment balance. Thus, F2 hybrids 12, 25, and 27 should be obtained to produce new cultivars of biofortified red and green lettuce for curly, american, mini, and romaine lettuce segments. goal problems Thus essential Lactuca L. L improvements study content BG Biofort hybridization carotenoids, , carotenoids) 2 3 strains, (strains 1 UFU189#3#4#1 UFU189341 189#3#4#1 189 4 (UFU-189#3#4# UFU66#4#2 UFU6642 UFU66 (UFU66#4# UFU-189#3#4#1 dualpurpose dual purpose yield biofortification. . biofortification) BIOFORT1 balance F curly american mini segments UFU189 UFU189#3#4# UFU18934 189341 189#3#4# 18 (UFU-189#3#4 UFU66#4# UFU664 UFU6 (UFU66#4 UFU-189#3#4# UFU18 UFU189#3#4 UFU1893 18934 189#3#4 (UFU-189#3# UFU66#4 (UFU66# UFU-189#3#4 UFU1 UFU189#3# 1893 189#3# (UFU-189#3 UFU66# (UFU66 UFU-189#3# UFU189#3 189#3 (UFU-189# (UFU6 UFU-189#3 UFU189# 189# (UFU-189 (UFU UFU-189# (UFU-18 UFU-189 (UFU-1 UFU-18 (UFU- UFU-1 UFU-

RESUMO A correlação canônica é usada para correlacionar grupos de variáveis distintas. O objetivo deste estudo foi utilizar análise de correlação canônica para avaliar a interação entre atributos de qualidade da água causadores de entupimento e o desempenho hidráulico de gotejadores não autocompensantes operando com diluições de efluente de aquicultura em água de poço. O experimento foi conduzido em delineamento inteiramente casualizado, em esquema de parcelas subsubdivididas, com três repetições, com cinco diluições nas parcelas (Diluição 1: 100% de efluente de aquicultura; Diluição 2: 75% de efluente de aquicultura + 25% de água de poço; Diluição 3 : 50% efluente de aquicultura + 50% água de poço; Diluição 4: 25% efluente de aquicultura + 75% água de poço; e Diluição 5: 100% água de poço), três emissores nas subparcelas (ST (1,6 L h-1) , SL (1,6 L h-1) e NJ (1,7 L h-1)), e três tempos de operação nas subsubparcelas (início do experimento, 80 e 160 horas, em que 0 horas de operação significa o início das avaliações). As análises estatísticas realizadas foram matriz de correlação e análise canônica. A análise de correlação canônica indicou que quando as concentrações dos atributos aumentam, o desempenho hidráulico dos gotejadores diminui. A interação desse grupo de atributos indica que o entupimento dos gotejadores que operam com as cinco diluições de efluente de aquicultura em água de poço ocorre pela ação combinada de agentes físicos, químicos e biológicos. O gotejador ST foi o menos sensível ao grupo de atributos de qualidade das diluições, enquanto o mais sensível foi o gotejador SL. distintas casualizado subsubdivididas repetições 1 100 2 75 25 50 4 5 poço, poço) 1,6 16 6 (1, h1 h h-1 1,7 17 7 h1, h-1)) 8 avaliações. avaliações . avaliações) aumentam diminui físicos biológicos 10 1, (1 h- (

ABSTRACT The canonical correlation is used to correlate groups of distinct variables. The objective of this study was to use canonical correlation analysis to evaluate the interaction between water quality attributes clogging-causing and the hydraulic performance of non-pressure compensating drippers operating with dilutions of aquaculture effluent in well water. The experiment was in a completely randomized design in a split-split-plot scheme with three replicates, with five dilutions in the plots (Dilution 1: 100% aquaculture effluent; Dilution 2: 75% aquaculture effluent + 25% well water; Dilution 3: 50% aquaculture effluent + 50% well water; Dilution 4: 25% aquaculture effluent + 75% well water; and Dilution 5: 100% well water), three emitters in the sub-plots (ST (1.6 L h-1), SL (1.6 L h-1) and NJ (1.7 L h-1)), and three operating times in the sub-subplots (0, 80 and 160 hours, in which 0 hours operating time means the start of evaluations). The statistical analyses performed were correlation matrix and canonical analysis. The canonical correlation analysis indicated that when the concentrations of attributes increase, the hydraulic performance of the drippers decreases. The interaction of this group of attributes indicates that the clogging of drippers operating with the five dilutions of aquaculture effluent in well water occurs by the combined action of physical, chemical, and biological agents. The ST dripper was the least sensitive to the group of quality attributes of the dilutions, whereas the most sensitive was the SL dripper. variables cloggingcausing causing nonpressure non pressure splitsplitplot split plot replicates 1 100 2 75 25 3 50 4 5 water, , water) subplots sub 1.6 16 6 (1. h1, h1 h h-1 1.7 17 7 h-1)) subsubplots 0, (0 8 evaluations. evaluations . evaluations) increase decreases physical chemical agents 10 1. (1 h- (

RESUMO: O uso da resistência de plantas atua intervindo na relação herbívoro-hospedeiro, através de fatores morfológicos, físicos ou químicos da planta. O objetivo deste trabalho foi avaliar a oviposição e o consumo foliar de Chrysodeixis includens (Walker [1858]) em genótipos de soja, através de testes com e sem escolha, correlacionando-os com os fatores, densidade e tamanho de tricomas. Os experimentos foram realizados em laboratório (25 ± 2 °C; UR= 70 ± 10%; fotoperíodo 14h) utilizando cinco cultivares (BRS 391, BRS 6203 RR, BMX Valente RR, Tec Irga 6070 RR, BMX Icone Ipro) e duas linhagens (PELBR 10-6000 e PELBR 10-6049). Os tricomas encontrados foram tectores filiformes e glandulares multicelulares claviformes. A densidade de tricomas glandulares nos estágios V2 e V5, foi maior em BRS 6203 RR e BRS 391, respectivamente. A maior densidade de tricomas glandulares foi observada em V5 e a maior densidade de tricomas tectores em V2. As menores densidades e os menores tamanhos de tricomas nos estágios V2 e V5 foram observados em PELBR 10-6049. O tamanho de tricomas tectores e o número de ovos não diferiram entre as cultivares. O consumo foliar foi menor para BMX Icone Ipro e Tec Irga 6070 RR. A densidade de tricomas influência o comportamento de consumo e oviposição de C. includens. RESUMO herbívorohospedeiro, herbívorohospedeiro herbívoro hospedeiro, hospedeiro herbívoro-hospedeiro morfológicos planta Walker 1858 [1858] soja escolha correlacionandoos correlacionando 25 (2 °C C UR 7 10% 10 14h h 391 620 607 106000 6000 10-600 106049. 106049 6049 . 10-6049) claviformes V respectivamente 6049. 10-6049 185 [1858 ( 1 39 62 60 10600 600 10-60 10604 604 10-604 18 [185 3 6 1060 10-6 [18 106 10- [1 [

ABSTRACT: The use of plant resistance acts by intervening in the herbivore-host relationship, through morphological, physical or chemical factors of the plant. This study evaluated the oviposition and foliar consumption of Chrysodeixis includens (Walker [1858]) in soybean genotypes, in free- and no-choice tests, correlating them with the factors, density and size of trichomes. The experiments were carried out in laboratory (25 ± 2 °C; RH= 70 ± 10%; photoperiod 14h) using five cultivars (BRS 391, BRS 6203 RR, BMX Valente RR, Tec Irga 6070 RR, BMX Icone Ipro) and two isolines (PELBR 10-6000 and PELBR 10-6049). The trichomes reported were filiform tectors and claviform multicellular glandular. The density of glandular trichomes, in stages V2 and V5, was higher on BRS 6203 RR and BRS 391, respectively. The higher density of glandular trichomes was observed in V5 and a higher density of tector trichomes in V2. The lowest densities and the smallest sizes of trichomes in V2 and V5 stages was observed on PELBR 10-6049. The size of tector trichomes and the number of eggs did not differ among the cultivars. Foliar consumption was lower for on BMX Icone Ipro and Tec Irga 6070 RR. Trichome density influences the consumption and oviposition behavior of C. includens. ABSTRACT herbivorehost herbivore host relationship morphological Walker 1858 [1858] genotypes free nochoice no choice tests 25 (2 °C C RH 7 10% 10 14h h 391 620 607 106000 6000 10-600 106049. 106049 6049 . 10-6049) V respectively 6049. 10-6049 185 [1858 ( 1 39 62 60 10600 600 10-60 10604 604 10-604 18 [185 3 6 1060 10-6 [18 106 10- [1 [

Resumo O artigo analisa a polarização ideológica dos deputados federais brasileiros entre 2005-2021. Utiliza como base empírica surveys realizadas com parlamentares durante o período (Brazilian Legislative Survey [BLS] e o Latin American Elites project of the University of Salamanca [PELA-USAL]). São encontradas evidências que os parlamentares brasileiros se tornaram mais liberais em temas culturais e com posições em favor do mercado acerca das questões econômicas. Quando as posições são analisadas por partido e sua localização no eixo esquerda/direita, encontraram-se evidências de uma maior diferenciação entre os partidos à medida que nos afastamos de 2005. Porém, isso não significa que estejamos diante de um sistema partidário polarizado. O mais correto seria afirmar que estamos diante de um quadro de partidos mais diferenciados num sistema não polarizado. 20052021. 20052021 2005 2021. 2021 2005-2021 Brazilian BLS [BLS PELAUSAL. PELAUSAL PELA USAL . [PELA-USAL]) econômicas esquerdadireita esquerda direita esquerda/direita encontraramse encontraram Porém polarizado 2005202 200 202 2005-202 [PELA-USAL] 200520 20 2005-20 [PELA-USAL 20052 2 2005-2 2005-

Abstract The article examines the ideological polarization of Brazilian federal deputies from 2005 to 2021. It relies on empirical data from surveys conducted with lawmakers during this period (Brazilian Legislative Survey [BLS] and the Latin American Elites project of the University of Salamanca [PELA-USAL]). The findings indicate that Brazilian lawmakers have become more liberal on cultural issues and hold more pro-market positions on economic issues. When analyzing positions by party and their position on the left/right spectrum, evidence showed a greater differentiation among parties as we move further away from 2005. However, this does not necessarily imply a polarized party system. A more accurate characterization might be that we are dealing with a landscape of more differentiated parties within a non-polarized system. 200 2021 BLS [BLS PELAUSAL. PELAUSAL PELA USAL . [PELA-USAL]) promarket pro market leftright left right spectrum However system nonpolarized non 20 202 [PELA-USAL] 2 [PELA-USAL

Resumen Este artículo analiza la polarización ideológica de los diputados federales brasileños en el período 2005-2021. Utiliza como base empírica encuestas realizadas a parlamentarios durante el período (Brazilian Legislative Survey [BLS] y el proyecto Élites Latinoamericanas de la Universidad de Salamanca [PELA-USAL]). Se encuentra evidencia de que los parlamentarios brasileños se han vuelto más liberales en temas culturales y tienen posiciones a favor del mercado en temas económicos. Cuando se analizan las posiciones por partido y su ubicación en el eje izquierda/derecha, se observa una mayor diferenciación entre los partidos a medida que nos distanciamos de 2005. Sin embargo, esto no significa que estemos ante un sistema de partidos polarizado. Sería más exacto decir que tenemos partidos más diferenciados en un sistema no polarizado. 20052021. 20052021 2005 2021. 2021 2005-2021 Brazilian BLS [BLS PELAUSAL. PELAUSAL PELA USAL . [PELA-USAL]) económicos izquierdaderecha izquierda derecha izquierda/derecha embargo polarizado 2005202 200 202 2005-202 [PELA-USAL] 200520 20 2005-20 [PELA-USAL 20052 2 2005-2 2005-

RESUMO Considerando a importância de se avaliar a compatibilidade entre o sistema de exploração usualmente empregado na Caatinga e o processo de regeneração da vegetação, este estudo objetivou avaliar a viabilidade de recuperação dos parâmetros estruturais em uma unidade experimental submetida a diferentes sistemas de manejo com idades de 9, 12, 16, 20 e 26 anos pós-exploração. A área foi submetida aos regimes de corte raso (CR) e três tipos de cortes seletivos (SC1 – corte seletivo 1, de árvores com diâmetro na base – DNB < 15 cm; SC2 – corte seletivo 2, de DNB > 10 cm; e SC3 – corte seletivo 2, de DNB entre 5 e 10 cm). Em parcelas permanentes de 20 m × 20 m, foram mensurados os indivíduos com CAP ≥ 6 cm e altura total superior a 1,0 m. Ao longo dos anos de monitoramento, o CR apresentou os menores valores de densidade, dominância e volume, não obtendo recuperação em área basal e volume mesmo após 26 anos de regeneração. Os tratamentos SC2 e SC3 se sobressaíram quanto à recuperação do estoque original de biomassa lenhosa, apresentando valores superiores aos originais e indicando que os dados iniciais não correspondiam ao potencial máximo do sítio. A dinâmica florestal apontou à insuficiência do ciclo de corte raso de 15 anos quanto à recuperação da composição e estrutura florestal nesta região. vegetação 9 12 16 2 pósexploração. pósexploração pós exploração. pós-exploração (CR SC1 SC (SC 1 cm. . cm) 0 monitoramento densidade lenhosa sítio região

ABSTRACT Considering the importance of evaluating the compatibility between the exploration system usually used in the Caatinga and the vegetation regeneration process, this study aimed to evaluate the feasibility of recovering structural parameters in an experimental unit subjected to different management systems aged 9, 12, 16, 20 and 26 years post-exploitation. The area was subjected to clearcutting (CC) regimes and three types of selective cuttings (SC1 – selective cutting 1, cut of trees with diameter at the base – DAB < 15 cm; SC2 – selective cutting 2, cut of trees with DAB > 10 cm; and SC3 – selective cutting 3, cut of trees with DAB between 5 and 10 cm). In permanent plots of 20 m × 20 m, individuals with a circumference at breast height (CBH) ≥ 6 cm and a total height greater than 1.0 m were measured. Over the years of monitoring, the CC presented the lowest values of density, dominance, and volume, not obtaining a recovery in basal area and volume even after 26 years of regeneration. Treatments SC2 and SC3 stood out regarding recovery of the original woody biomass stock, presenting values higher than the original ones and indicating that the initial data did not correspond to the site's maximum potential. The forest dynamics pointed to the insufficiency of the 15-year clearcutting cycle in terms of recovering this region forest composition and structure. process 9 12 16 2 postexploitation. postexploitation post exploitation. exploitation post-exploitation (CC SC1 SC (SC 1 3 cm. . cm) CBH (CBH 0 1. measured monitoring density dominance stock sites site s potential 15year year structure

Resumo Fundamento: As ferramentas de telecardiologia são estratégias valiosas para melhorar a estratificação de risco. Objetivo: Objetivamos avaliar a acurácia da tele-eletrocardiografia (ECG) para predizer anormalidades no ecocardiograma de rastreamento na atenção primária. Métodos: Em 17 meses, 6 profissionais de saúde em 16 unidades de atenção primária foram treinados em protocolos simplificados de ecocardiografia portátil. Tele-ECGs foram registrados para diagnóstico final por um cardiologista. Pacientes consentidos com anormalidades maiores no ECG pelo código de Minnesota e uma amostra 1:5 de indivíduos normais foram submetidos a um questionário clínico e ecocardiograma de rastreamento interpretado remotamente. A doença cardíaca grave foi definida como doença valvular moderada/grave, disfunção/hipertrofia ventricular, derrame pericárdico ou anormalidade da motilidade. A associação entre alterações maiores do ECG e anormalidades ecocardiográficas foi avaliada por regressão logística da seguinte forma: 1) modelo não ajustado; 2) modelo 1 ajustado por idade/sexo; 3) modelo 2 mais fatores de risco (hipertensão/diabetes); 4) modelo 3 mais história de doença cardiovascular (Chagas/cardiopatia reumática/cardiopatia isquêmica/AVC/insuficiência cardíaca). Foram considerados significativos valores de p < 0,05. Resultados: No total, 1.411 pacientes realizaram ecocardiograma, sendo 1.149 (81%) com anormalidades maiores no ECG. A idade mediana foi de 67 anos (intervalo interquartil de 60 a 74) e 51,4% eram do sexo masculino. As anormalidades maiores no ECG se associaram a uma chance 2,4 vezes maior de doença cardíaca grave no ecocardiograma de rastreamento na análise bivariada (OR = 2,42 [IC 95% 1,76 a 3,39]) e permaneceram significativas (p < 0,001) após ajustes no modelo 2 (OR = 2,57 [IC 95% 1,84 a 3,65]), modelo 3 (OR = 2,52 [IC 95% 1,80 a 3,58]) e modelo 4 (OR = 2,23 [IC 95% 1,59 a 3,19]). Idade, sexo masculino, insuficiência cardíaca e doença cardíaca isquêmica também foram preditores independentes de doença cardíaca grave no ecocardiograma. Conclusões: As anormalidades do tele-ECG aumentaram a probabilidade de doença cardíaca grave no ecocardiograma de rastreamento, mesmo após ajustes para variáveis demográficas e clínicas. Fundamento Objetivo teleeletrocardiografia tele eletrocardiografia (ECG Métodos meses portátil TeleECGs Tele ECGs cardiologista 15 5 1: remotamente moderadagrave moderada moderada/grave disfunçãohipertrofia disfunção hipertrofia ventricular motilidade forma idade/sexo idadesexo hipertensão/diabetes hipertensãodiabetes hipertensão diabetes (hipertensão/diabetes) Chagas/cardiopatia Chagascardiopatia Chagas cardiopatia reumáticacardiopatia reumática isquêmicaAVCinsuficiência AVC cardíaca. . cardíaca) 005 0 05 0,05 Resultados total 1411 411 1.41 1149 149 1.14 81% 81 (81% intervalo 74 514 51 51,4 masculino 24 2, OR 242 42 IC 95 176 76 1,7 3,39 339 39 3,39] 0,001 0001 001 257 57 2,5 184 84 1,8 3,65, 365 3,65 , 65 3,65]) 252 52 180 80 3,58 358 58 3,58] 223 23 2,2 159 59 1,5 3,19. 319 3,19 19 3,19]) Idade Conclusões teleECG clínicas (hipertensão/diabetes 00 0,0 141 41 1.4 114 14 1.1 8 (81 7 51, 9 1, 3,3 33 0,00 000 25 18 36 3,6 3,65] 3,5 35 22 31 3,1 3,19] 0, 1. 11 (8 3, (

Abstract Background: Tele-cardiology tools are valuable strategies to improve risk stratification. Objective: We aimed to evaluate the accuracy of tele-electrocardiography (ECG) to predict abnormalities in screening echocardiography (echo) in primary care (PC). Methods: In 17 months, 6 health providers at 16 PC units were trained on simplified handheld echo protocols. Tele-ECGs were recorded for final diagnosis by a cardiologist. Consented patients with major ECG abnormalities by the Minnesota code, and a 1:5 sample of normal individuals underwent clinical questionnaire and screening echo interpreted remotely. Major heart disease was defined as moderate/severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion, or wall-motion abnormalities. Association between major ECG and echo abnormalities was assessed by logistic regression as follows: 1) unadjusted model; 2) model 1 adjusted for age/sex; 3) model 2 plus risk factors (hypertension/diabetes); 4) model 3 plus history of cardiovascular disease (Chagas/rheumatic heart disease/ischemic heart disease/stroke/heart failure). P-values < 0.05 were considered significant. Results: A total 1,411 patients underwent echo; 1,149 (81%) had major ECG abnormalities. Median age was 67 (IQR 60 to 74) years, and 51.4% were male. Major ECG abnormalities were associated with a 2.4-fold chance of major heart disease on echo in bivariate analysis (OR = 2.42 [95% CI 1.76 to 3.39]), and remained significant after adjustments in models (p < 0.001) 2 (OR = 2.57 [95% CI 1.84 to 3.65]), model 3 (OR = 2.52 [95% CI 1.80 to3.58]), and model 4 (OR = 2.23 [95%CI 1.59 to 3.19]). Age, male sex, heart failure, and ischemic heart disease were also independent predictors of major heart disease on echo. Conclusions: Tele-ECG abnormalities increased the likelihood of major heart disease on screening echo, even after adjustments for demographic and clinical variables. Background Telecardiology Tele cardiology stratification Objective teleelectrocardiography tele electrocardiography (ECG (echo PC. . (PC) Methods months protocols TeleECGs ECGs cardiologist code 15 5 1: remotely moderatesevere moderate severe dysfunctionhypertrophy dysfunction hypertrophy dysfunction/hypertrophy effusion wallmotion wall motion follows age/sex agesex sex hypertension/diabetes hypertensiondiabetes hypertension diabetes (hypertension/diabetes) Chagas/rheumatic Chagasrheumatic Chagas rheumatic diseaseischemic diseasestrokeheart stroke failure. failure failure) Pvalues P values 005 0 05 0.0 Results 1411 411 1,41 1149 149 1,14 81% 81 (81% IQR 74 years 514 51 51.4 2.4fold 24fold fold 2.4 OR 242 42 95% 95 [95 176 76 1.7 3.39, 339 3.39 , 39 3.39]) p 0.001 0001 001 257 57 2.5 184 84 1.8 3.65, 365 3.65 65 3.65]) 252 52 180 80 to3.58, to358 to3.58 to3 58 to3.58]) 223 23 2.2 95%CI 95CI 159 59 1.5 3.19. 319 3.19 19 3.19]) Age Conclusions TeleECG variables (PC (hypertension/diabetes 00 0. 141 41 1,4 114 14 1,1 8 (81 7 51. 4fold 24 2. 9 [9 1. 33 3.3 3.39] 0.00 000 25 18 36 3.6 3.65] to35 to3.5 to3.58] 22 31 3.1 3.19] 1, 11 (8 [ 3. to3. (

RESUMO O déficit hídrico ou alagamento podem ocasionar danos nas plantas, como Eugenia myrcianthes Nied. Assim, o conhecimento de tecnologias que possam mitigar os danos causados pelo estresse é necessário para o cultivo ex situ dessas espécies. Objetivou-se avaliar o potencial do hidrogel (H) em mitigar o estresse hídrico e de auxiliar na recuperação de mudas de Eugenia myrcianthes Nied. sob flutuações hídricas. As mudas foram separadas em três regimes hídricos: R1) irrigação contínua (controle), R2) Estresse intermitente: caracterizado por dois ciclos de estresse, sendo o primeiro a restrição hídrica, e o segundo alagamento (Estresse hídrico) e R3) Estresse intermitente + Hidrogel - Forth® gel (Estresse + H). As avaliações foram realizadas em seis épocas: tempo zero, 1ª fotossíntese zero (F0), 1ª recuperação (REC), 2ª F0, 2ª REC e FINAL. Foram avaliadas características fotoquímicas, morfológicas e antioxidantes. As mudas de E. myrcianthes responderam às flutuações hídricas, havendo redução das trocas gasosas. As plantas sob estresse, independente do H, aumentaram a atividade das enzimas superóxido dismutase, peroxidase e do conteúdo do aminoácido prolina. Conclui-se que mudas de E. myrcianthes apresentaram mudanças fisiológicas quanto ao déficit hídrico e alagamento, mas o H não contribuiu em aliviar o déficit hídrico sobre as trocas gasosas e não prejudicou no alagamento. As mudas apresentaram sobrevivência, retomada do metabolismo após as condições estressantes demonstrando capacidade de resiliência por plasticidade fisiológica, independente do uso do hidrogel. Nied Assim espécies Objetivouse Objetivou se (H hídricas hídricos R1 R controle, controle , (controle) R2 hídrica R3 Forth H. . H) épocas ª F0 F (F0) REC, (REC) FINAL fotoquímicas antioxidantes E dismutase prolina Concluise Conclui sobrevivência fisiológica (controle (F0 (REC (F

ABSTRACT Water deficit or flooding can damage the photosynthetic and enzymatic metabolism in plants such as Eugenia myrcianthes Nied. Thus, knowledge of technologies that can mitigate stress damage is necessary for the ex-situ cultivation of these species. This study evaluates the potential of hydrogel (H) to mitigate water stress and assist in the recovery of E. myrcianthes seedlings under different water conditions. The seedlings were separated into three water regimes: R1 - continuous irrigation (control); R2 - intermittent stress, characterized by two stress cycles: water restriction followed by flooding (stress); and R3 - intermittent stress + hydrogel - Forth® gel (stress + H). Evaluations occurred in six periods: zero time (T0), 1st zero photosynthesis (P0), 1st recovery (REC), 2nd P0, 2nd REC, and END. E. myrcianthes seedlings responded to water conditions with reduced CO2 assimilation rate, transpiration, and stomatal conductance during stressful conditions. We observed decrease in the growth parameters of this species under stress, including leaf area and biomass. Under stress, independent of H, plants increased the activity of the enzymes superoxide dismutase, peroxidase, and the content of the amino acid proline. We observed recovery potential in most of the evaluated traits. E. myrcianthes seedlings showed morphophysiological changes due to water deficit and flooding. Still, hydrogel did not contribute to alleviating the effects of water deficit on gas exchange and did not affect flooding. Seedlings showed survival and resumption of metabolism and growth after stressful conditions. This demonstrates their resilience due to physiological plasticity, regardless of the use of hydrogel. Nied Thus exsitu ex situ H (H E regimes R control (control) cycles (stress) Forth H. . H) periods T0, T0 T , (T0) st P0 P (P0) REC (REC) nd END CO rate transpiration biomass dismutase peroxidase proline traits Still plasticity (control (T0 (P0 (REC (T (P

A new phenylpropanoid derivative, named euploic acid (1), was isolated from Euploca procumbens (Mill.) Diane & Hilger, Boraginaceae, along with lithospermic acid B (2), lithospermic acid (3), 9’’-methyl lithospermate (4), and luteolin-7-O-glucoside (5). Compound structures were determined by mass spectrometry (MS), nuclear magnetic resonance (NMR) analysis and comparison with published data. Absolute configuration of 1 was established via electronic circular dichroism (ECD). Anti-inflammatory potential of euploic acid (1) was assessed by measuring its inhibition of cytokine and nitric oxide production in stimulated J774 macrophages. Compound 1 significantly reduced pro-inflammatory mediator production and release by stimulated macrophages at non-cytotoxic concentrations, comparable to the efficacy of dexamethasone. Our findings demonstrate the potential of euploic acid (1) as an effective anti-inflammatory agent. This study contributes to the structural elucidation of a new phenylpropanoid derivative and highlights its promising anti-inflammatory activity in the treatment of inflammatory disorders. 1, , Mill. Mill (Mill. Hilger Boraginaceae 2, 2 (2) 3, 3 (3) 9methyl methyl 9 4, 4 (4) luteolin7Oglucoside luteolinOglucoside luteolin 7 O glucoside 5. 5 . (5) MS, MS (MS) NMR (NMR data ECD. ECD (ECD) Antiinflammatory Anti (1 J J77 proinflammatory pro noncytotoxic non cytotoxic concentrations dexamethasone antiinflammatory anti agent disorders (Mill (2 (3 (4 Oglucoside (5 (MS (ECD ( J7

In this study, nanostructured coatings of VN2/Fe3N/Fe4N are synthesized by Plasma Deposition (CCPD) using a vanadium cathodic cage and subject to cathodic and floating potential treatments. Microstructural and mechanical properties of coated SAE 1080 steel samples are investigated using X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Vickers microhardness (HV), and surface roughness analysis. The coating produced under cathodic potential treatment exhibited a nitride-based microstructure (VN2, Fe3N, Fe4N), with surface morphology consisting of clusters of granular structures with varied particle sizes. The coating produced under floating potential predominantly exhibited the iron nitride phase (Fe3N) with a morphology composed of uniformly sized grains. Microhardness testing showed that both layers exhibited more excellent plastic deformation resistance than the substrate. Roughness measurements confirmed a more organized microstructure profile for the sample treated under floating potential. This study demonstrates that the CCPD-produced cathodic potential coating can be utilized in tribological applications. VN2Fe3NFe4N VNFeNFeN VN2 Fe3N Fe4N VN Fe N CCPD (CCPD treatments 108 Xray X ray XRD, XRD , (XRD) SEM, SEM (SEM) HV, HV (HV) analysis nitridebased based VN2, (VN2 FeN Fe4N, Fe4N) sizes (Fe3N grains substrate CCPDproduced applications NFe 10 (XRD (SEM (HV (VN 1

Abstract Polyvinylidene fluoride (PVDF) is a versatile and low-cost polymer with high biocompatibility, mechanical strength, chemical resistance, thermal stability, and ferroelectricity. This material has been widely used in many applications, ranging from membranes to electronic devices. In this study, self-supporting, flexible, and lightweight PVDF films were prepared by an evaporation route using a low-toxicity solvent (dimethyl sulfoxide – DMSO). Graphene oxide (GO) and anatase titania (TiO2) were incorporated into the PVDF after preparing DMSO-based suspensions of these materials. The prepared materials were examined in terms of their structural, electrical, and wetting properties before and after exposure to near ultraviolet (UV-A) light. Substantial structural changes took place after incorporating GO and TiO2 into PVDF. Such modifications were accompanied by dramatic changes in the wetting and electrical properties of the PVDF. UV-A light caused the formation of surface defects on PVDF and GO films. In addition, it promoted the photoreduction of GO into reduced graphene oxide (rGO). Composites containing TiO2 showed high resistance to UV-A light, probably because titania particles absorb the incoming photons and shield the polymer matrix. This study provides new insights into the synthesis and characterization of PVDF/TiO2/GO composite films, which may be useful for many applications, including flexible electronics, solar cells, and biomedical devices. (PVDF lowcost low cost biocompatibility strength stability ferroelectricity applications devices selfsupporting, selfsupporting self supporting, supporting self-supporting lowtoxicity toxicity dimethyl DMSO. DMSO . DMSO) (GO TiO (TiO2 DMSObased based UVA UV A (UV-A addition rGO. rGO (rGO) matrix PVDFTiO2GO PVDFTiOGO electronics cells (TiO (rGO PVDFTiO

Abstract Purpose: The purpose of this study was to investigate the peripheral and central auditory pathways in adult individuals after COVID-19 infection. Method: A total of 44 individuals aged between 19 and 58 years, of both genders, post-COVID-19 infection, confirmed by serological tests, with no previous hearing complaints and no risk factors for hearing loss, were assessed. All the participants underwent the following procedures: pure tone audiometry, logoaudiometry, immitanciometry, and Brainstem Auditory Evoked Potentials (BAEP), in addition to answering a questionnaire about auditory symptoms. Results: Thirteen individuals (29.5 %) had some hearing threshold impairment, mainly sensorineural hearing loss. In the BAEP, 18 individuals (40.9 %) presented longer latencies, mainly in waves III and V. According to the questionnaire answers, 3 individuals (9.1 %) reported worsened hearing and 7 (15.9 %) tinnitus that emerged after the infection. As for the use of ototoxic drugs during treatment, 7 individuals (15.9 %) reported their use, of which 5 showed abnormalities in peripheral and/or central auditory assessments. Conclusion: Considering the self-reported hearing complaints after COVID-19 infection and the high rate of abnormalities found in both peripheral and central audiological assessments, it is suggested that the new COVID-19 may compromise the auditory system. Due to the many variables involved in this study, the results should be considered with caution. However, it is essential that audiological evaluations are carried out on post-COVID-19 patients in order to assess the effects of the infection in the short, medium, and long term. Future longitudinal investigations are important for a better understanding of the auditory consequences of COVID-19. Purpose COVID19 COVID COVID-1 Method 4 1 years genders postCOVID19 postCOVID post post-COVID-1 tests loss assessed procedures audiometry logoaudiometry immitanciometry BAEP , (BAEP) symptoms Results 29.5 295 29 (29. % impairment 40.9 409 40 9 (40. latencies V answers 9.1 91 (9. 15.9 159 15 (15. treatment andor or assessments Conclusion selfreported self system caution However short medium term COVID19. 19. COVID1 COVID- postCOVID1 post-COVID- (BAEP 29. 2 (29 40. (40 9. (9 15. (15 post-COVID (2 (4 ( (1

Abstract This article provides the first records of courtship behavior and a mating event of free-ranging whitespotted eagle rays ( Aetobatus narinari ) in Brazilian waters. These observations shed light on utilizing the marine no-take zone surrounding the Anchieta Island State Park as a mating site in the South Atlantic region. Sightings of the species in shallower areas notably increased throughout summer months (from January to March, 2023 and from January to February, 2024), which aligns with its known reproductive period. Specifically, the mating event occurred in March 2023, followed by observations of courtship behavior in January 2024. While the population dynamics and impact of fisheries remain poorly understood, the species is frequently captured by traditional fishing fleets and traded locally. This reiterates the importance of the local Marine Protected Areas (MPAs) and underlines the urgency for their expansion, alongside the need for further studies that support specific management actions. freeranging free ranging waters notake no take region 202 February 2024, 2024 , 2024) period Specifically understood locally MPAs (MPAs expansion actions 20 2

Abstract Urban parks are not only important for the wellbeing of the human population, but are also widely considered to be potentially important sites for the conservation of biodiversity. However, they may offer risk parasitic infections, such as schistosomiasis and fascioliasis, which are both transmitted by freshwater snails. The present study investigated the occurrence of freshwater gastropods in urban parks of the Brazilian city of Rio de Janeiro, and their possible infection by helminths of medical-veterinary importance. Gastropods were collected from six parks (2021 - 2022) and examined for the presence of larval helminths. In all, 12 gastropod species from different families were collected: Ampullariidae, Assimineidae, Burnupidae, Lymnaeidae, Physidae, Planorbidae, Succineidae, and Thiaridae. The parasitological examination revealed cercaria of three types in five snail species, with the Pleurolophocerca cercariae type in Melanoides tuberculata (the most abundant species), Echinostoma cercariae in Physella acuta and Pomacea maculata, and Virgulate cercariae, in Pomacea sp. and Pomacea maculata. None of the Biomphalaria tenagophila and Pseudosuccinea columella (the most frequent species) specimens were parasitized by Schistosoma mansoni or Fasciola hepatica, respectively. Even so, some parks may represent a considerable potential risk for transmission of both Schistosoma mansoni and Fasciola hepatica, given the presence of these gastropod vectors and the frequent contact of visitors with the waterbodies. population biodiversity However infections fascioliasis snails Janeiro medicalveterinary medical veterinary importance 2021 (202 2022 all 1 Ampullariidae Assimineidae Burnupidae Lymnaeidae Physidae Planorbidae Succineidae Thiaridae , maculata sp hepatica respectively so waterbodies 202 (20 20 (2 2 (

The process of photosynthesis involves the absorption of light energy by photosynthetic pigments found in the thylakoid membrane of chloroplasts in order to produce chemical energy. In the presence of photosynthetic inhibitors, plant development is affected mainly by the reduction of the electron chain, which leads to growth inhibition. In this context, chlorophyll a (Chl a) fluorescence is an important technique used to identify the effects of inhibitors on the photosynthetic apparatus employing the JIP-test, which correlates the Chl a fluorescence transient to biophysical parameters, providing valuable information about the efficiency of photosystems I and II. Natural products have been highlighted as photosynthesis inhibitors due to the continued use of synthetic herbicides, which leads to the development of invasive plants resistant to these pesticides, in addition to the toxicity caused to humans and the environment. Thus, this review describes the main applications of extracts and isolated secondary metabolites obtained from plants and microorganisms in the investigation of electron transport inhibition on photosystem II. chain context JIPtest, JIPtest JIP test, test JIP-test parameters II herbicides pesticides environment Thus

RESUMO: Este estudo investigou a presença de bactérias potencialmente zoonóticas e resistentes a antimicrobianos em psitacídeos criados em ambiente doméstico. Esse projeto foi aprovado pela Comissão de Ética para o Uso de Animais da Universidade Estadual do Ceará (CEUA-UECE), registrado sob o número 03423745/2023. Foram coletadas 111 amostras de suabes cloacais de psitacídeos exóticos de seis espécies, incluindo, periquitos-australianos (Melopsittacus undulatus), calopsitas (Nymphicus hollandicus), agapornis (Agapornis sp.), periquitos-de-colar (Psittacula krameri), periquitos-dorso-vermelho (Psephotus haematonotus) e roselas (Platycercus eximius). Foi realizado o isolamento e a identificação de enterobactérias e determinado o perfil de resistência. Das amostras coletadas, 70,2% (78/111) apresentaram crescimento para uma ou mais enterobactérias. Foram isoladas 110 cepas pertencentes a 13 espécies bacterianas. Escherichia coli apresentou o maior índice de isolamento, com 30% (33/110). Em segundo lugar Pantoea agglomerans, com um percentual de isolamento de 27,2% (30/110). Observou-se que 35,4% (39/110) das enterobactérias apresentaram resistência à tobramicina, seguidas da tetraciclina com 34,5% (38/110) e da fosfomicina com 30,9% (34/110). E. coli apresentou maior taxa de resistência a tetraciclina com 51,5% (17/33), seguida de 36,6% (12/33) para tobramicina e 15,1% (5/33) para gentamicina. Das enterobactérias analisadas 28,9% (32/110), apresentaram multirresistência. Os resultados indicam uma alta prevalência de enterobactérias, a resistência antimicrobiana foi constatada em diversas classes de antimicrobianos. RESUMO doméstico CEUAUECE, CEUAUECE CEUA UECE , (CEUA-UECE) 034237452023 03423745 2023 03423745/2023 11 incluindo periquitosaustralianos periquitos australianos Melopsittacus undulatus, undulatus undulatus) Nymphicus hollandicus, hollandicus hollandicus) Agapornis sp., sp sp. sp.) periquitosdecolar colar Psittacula krameri, krameri krameri) periquitosdorsovermelho dorso vermelho Psephotus haematonotus Platycercus eximius. eximius . eximius) 702 70 2 70,2 78/111 78111 78 (78/111 1 bacterianas 30 33/110. 33110 33/110 33 (33/110) agglomerans 272 27 27,2 30/110. 30110 30/110 (30/110) Observouse Observou se 354 35 4 35,4 39/110 39110 39 (39/110 345 34 5 34,5 38/110 38110 38 (38/110 309 9 30,9 34/110. 34110 34/110 (34/110) E 515 51 51,5 17/33, 1733 17/33 17 (17/33) 366 36 6 36,6 12/33 1233 12 (12/33 151 15 15,1 5/33 533 (5/33 gentamicina 289 28 28,9 32/110, 32110 32/110 32 (32/110) multirresistência (CEUA-UECE 03423745202 0342374 202 03423745/202 7 70, 78/11 7811 (78/11 3 3311 33/11 (33/110 27, 3011 30/11 (30/110 35, 39/11 3911 (39/11 34, 38/11 3811 (38/11 30, 3411 34/11 (34/110 51, 173 17/3 (17/33 36, 12/3 123 (12/3 15, 5/3 53 (5/3 28, 3211 32/11 (32/110 0342374520 034237 20 03423745/20 78/1 781 (78/1 331 33/1 (33/11 301 30/1 (30/11 39/1 391 (39/1 38/1 381 (38/1 341 34/1 (34/11 17/ (17/3 12/ (12/ 5/ (5/ 321 32/1 (32/11 034237452 03423 03423745/2 78/ (78/ 33/ (33/1 30/ (30/1 39/ (39/ 38/ (38/ 34/ (34/1 (17/ (12 (5 32/ (32/1 0342 03423745/ (78 (33/ (30/ (39 (38 (34/ (17 (1 ( (32/ 034 (7 (33 (30 (3 (34 (32 03 0

ABSTRACT: This investigation elucidated the presence of potentially zoonotic and antimicrobial-resistant bacteria in domestically reared psittacines. The present study was sanctioned by the Animal Ethics Committee of the State University of Ceará (CEUA-UECE) and bears registration number 03423745/2023. A total of 111 cloacal swab samples were procured from exotic psittacines encompassing six distinct species: the Australian budgerigar (Melopsittacus undulatus), cockatiels (Nymphicus hollandicus), lovebirds (Agapornis sp.), rose-ringed parakeets (Psittacula krameri), red-rumped parrots (Psephotus haematonotus), and rosellas (Platycercus eximius). The process encompassed the isolation and characterization of enterobacteria and ascertaining their resistance profiles. Among the collected specimens, 70.2% (78/111) yielded growth indicative of one or more enterobacterial agents. The collective isolates comprised 110 strains encompassing 13 distinct bacterial species. Foremost among these was Escherichia coli, accounting for a significant percentage of the total isolates at 30% (33/110), followed by Pantoea agglomerans at 27.2% (30/110). The study revealed that 35.4% (39/110) of the isolates exhibited resistance to tobramycin, with tetracycline and fosfomycin showing resistance rates of 34.5% (38/110) and 30.9% (34/110), respectively. Particularly noteworthy was that E. coli showed a heightened propensity for tetracycline resistance at 51.5% (17/33), while resistance rates to tobramycin and gentamicin were 36.6% (12/33) and 15.1% (5/33), respectively. A noteworthy subset of the enterobacterial cohort exhibited multidrug resistance patterns (28.9%, 32/110). Collectively, these outcomes underscore not only an elevated prevalence of enterobacterial strains but also the pervasive phenomenon of antimicrobial resistance across a diverse spectrum of antimicrobial agents. ABSTRACT antimicrobialresistant resistant CEUAUECE CEUA UECE (CEUA-UECE 034237452023 03423745 2023 03423745/2023 11 species Melopsittacus undulatus, undulatus , undulatus) Nymphicus hollandicus, hollandicus hollandicus) Agapornis sp., sp sp. sp.) roseringed rose ringed Psittacula krameri, krameri krameri) redrumped red rumped Psephotus haematonotus, haematonotus haematonotus) Platycercus eximius. eximius . eximius) profiles specimens 702 70 2 70.2 78/111 78111 78 (78/111 agents 1 30 33/110, 33110 33/110 33 (33/110) 272 27 27.2 30/110. 30110 30/110 (30/110) 354 35 4 35.4 39/110 39110 39 (39/110 345 34 5 34.5 38/110 38110 38 (38/110 309 9 30.9 34/110, 34110 34/110 (34/110) respectively E 515 51 51.5 17/33, 1733 17/33 17 (17/33) 366 36 6 36.6 12/33 1233 12 (12/33 151 15 15.1 5/33, 533 5/33 (5/33) 28.9%, 289 28 (28.9% 32/110. 32110 32/110 32 32/110) Collectively 03423745202 0342374 202 03423745/202 7 70. 78/11 7811 (78/11 3 3311 33/11 (33/110 27. 3011 30/11 (30/110 35. 39/11 3911 (39/11 34. 38/11 3811 (38/11 30. 3411 34/11 (34/110 51. 173 17/3 (17/33 36. 12/3 123 (12/3 15. 53 5/3 (5/33 28.9% (28.9 3211 32/11 0342374520 034237 20 03423745/20 78/1 781 (78/1 331 33/1 (33/11 301 30/1 (30/11 39/1 391 (39/1 38/1 381 (38/1 341 34/1 (34/11 17/ (17/3 12/ (12/ 5/ (5/3 28.9 (28. 321 32/1 034237452 03423 03423745/2 78/ (78/ 33/ (33/1 30/ (30/1 39/ (39/ 38/ (38/ 34/ (34/1 (17/ (12 (5/ 28. (28 32/ 0342 03423745/ (78 (33/ (30/ (39 (38 (34/ (17 (1 (5 (2 034 (7 (33 (30 (3 (34 ( 03 0