Resumen Objetivo Analizar la negativa familiar de donación de córneas para trasplante en una Organización de Búsqueda de Órganos. Métodos: Estudio cuantitativo tipo transversal sobre la negativa de córnea de donantes en situación de muerte encefálica. La fuente de datos estuvo compuesta por los Términos de Autorización de Donación de Órganos y Tejidos firmados entre enero de 2001 y diciembre de 2020 en una Organización de Búsqueda de Órganos. Se recopilaron los datos, luego se tabularon y se analizaron de forma descriptiva e inferencial. El presente estudio fue aprobado por el Comité de Ética en Investigación. Resultados De los 2447 Términos de Autorización de Donación de Órganos y Tejidos firmados en el período, 620 (25,34 %) negaron la donación de córneas. Con relación a la tendencia temporal de negativas de donación de córneas, el único período que presentó significación fue de 2001 a 2009, cuando los grupos de edad de 0 a 11 años y de 12 a 19 años demostraron una tendencia decreciente, y el grupo de edad mayor o igual a 60 años se mostró creciente. En el período total de 2001 a 2020, los grupos de edad de 20 a 40 años, de 41 a 59 años y mayor o igual a 60 años presentaron un 48 %, un 59 % y un 73 %, respectivamente, menor probabilidad de negativa de donación de córneas. Conclusión El grupo de edad presentó relación con la negativa, considerando que los individuos de mayor edad presentan mayores índices. Métodos encefálica 200 202 inferencial Investigación 244 62 25,34 2534 25 34 (25,3 2009 1 decreciente 6 creciente 2 4 5 7 respectivamente índices 24 25,3 253 3 (25, 25, (25 (2 (

Abstract Objective To analyze family refusals to donate a cornea for transplantation in an Organ Procurement Organization. Methods This was a quantitative cross-sectional study on corneal donation refusals from potential brain-dead donors. The data source was based on the Terms of Authorization for Donation of Organs and Tissues signed from January 2001 to December 2020 in an Organ Procurement Organization. Data were collected, tabulated, and analyzed in a descriptive and inferential manner. The present study was approved by the Research Ethics Committee. Results Of the 2,447 Terms of Authorization for Donation of Organs and Tissues signed in the above period, 620 (25.34%) of them refused to donate a cornea. Regarding the time trend of corneal donation refusals, the period 2001-2009 was the only one that showed significance, when the 0-11 and 12-19 age groups showed a decreasing trend and that of 60 years or older showed an increasing trend. In the period 2001-2020, the age groups of 20-40, 41-59, and 60 years or older had lower rates of refusal to donate a cornea (48%, 59%, and 73%, respectively). Conclusion The age group is associated with refusal because older individuals had the highest refusal rates. Organization crosssectional cross sectional braindead brain dead donors 200 202 collected tabulated manner Committee 2447 2 447 2,44 62 25.34% 2534 25 34 (25.34% 20012009 2009 2001-200 significance 011 0 11 0-1 1219 12 19 12-1 6 20012020, 20012020 2020, 2001-2020 2040, 2040 20 40, 40 20-40 4159, 4159 41 59, 59 41-59 48%, 48 (48% 59% 73 73% respectively. respectively . respectively) 244 44 2,4 25.34 253 3 (25.34 2001200 2001-20 01 1 0- 121 12- 2001202 2001-202 204 4 20-4 415 5 41-5 48% (48 7 24 2, 25.3 (25.3 200120 2001-2 20- 41- (4 25. (25. 20012 2001- ( (25 (2

Resumo Objetivo Analisar a recusa familiar de doação de córnea para transplante em uma Organização de Procura de Órgãos. Métodos Estudo quantitativo do tipo transversal sobre as recusas de córnea de doadores em situação de morte encefálica. A fonte de dados foi constituída pelos Termos de Autorização de Doação de Órgãos e Tecidos firmados entre janeiro de 2001 a dezembro de 2020 em uma Organização de Procura de Órgãos. Os dados foram coletados, tabulados e analisados de forma descritiva e inferencial. O presente estudo foi aprovado pelo Comitê de Ética em Pesquisa. Resultados Dos 2.447 Termos de Autorização de Doação de Órgãos e Tecidos firmados no período, 620 (25.34%) recusaram a doação de córneas. Com relação à tendência temporal de recusas de doação de córneas, o único período que apresentou significância foi de 2001 a 2009, quando as faixas etárias de zero a 11 anos e 12 a 19 anos demonstraram tendência decrescente, e a faixa etária maior ou igual a 60 anos, mostrou-se crescente. No período total de 2001 a 2020, as faixas etárias dos 20 a 40 anos, 41 a 59 anos e maior ou igual a 60 anos apresentaram, 48%, 59% e 73%, respectivamente, menores chances de recusa da doação de córneas. Conclusão A faixa etária apresentou associação com a recusa, tendo em vista que os indivíduos de maior idade apresentaram maiores índices. encefálica 200 202 coletados inferencial Pesquisa 2447 2 447 2.44 62 25.34% 2534 25 34 (25.34% córneas 2009 1 decrescente 6 mostrouse mostrou se crescente 4 5 48 48% 73 73% respectivamente índices 244 44 2.4 25.34 253 3 (25.34 7 24 2. 25.3 (25.3 25. (25. (25 (2 (

Resumen: Objetivo: describir las potencialidades y desafíos de las residentes sobre la experiencia en un Programa Nacional de Residencia en Enfermería Obstétrica, referido a la humanización del parto y el puerperio. Método: estudio descriptivo, exploratorio con abordaje cualitativo, realizado con seis enfermeras egresadas de la carrera de residencia en enfermería obstétrica de una universidad pública. Para la recolección de datos se realizaron entrevistas semiestructuradas, las cuales fueron analizadas por la Técnica de Análisis de Contenido, en la modalidad de Análisis Temático. Resultados: a partir de las reflexiones de las residentes, a través de las categorías emergentes, se pudo constatar que reconocieron como puntos positivos para la implementación de la humanización del parto y el puerperio: el apoyo de la coordinación y tutoría del curso de residencia obstétrica; la relación interpersonal clara y objetiva con todo el equipo multidisciplinario; la estructura física de la Institución. Al mismo tiempo identificaron como puntos negativos: la conquista del medio ambiente; resistencia del equipo multidisciplinario y de las pacientes; normas institucionales; y la cultura intervencionista. Conclusión: Se advierte que los residentes de enfermería obstétrica aún necesitan conquistar sus espacios en las maternidades de manera más enfática, lo que les permitirá una mayor autonomía, con miras a poner en práctica la implementación de nuevas estrategias, basadas en la humanización del cuidado.

Abstract: Objective: to describe the possibilities and challenges faced by residents who experienced a National Residency Program in Obstetric Nursing, regarding childbirth humanization and puerperium. Method: a descriptive, exploratory study, with a qualitative approach, carried out with six nurses who have completed the residency program in obstetric nursing at a public university. A semi-structured interview was used for data collection, which was analyzed by the Content Analysis Technique, in the Thematic Analysis modality. Results: the residents' reflections, through the emerging categories, highlighted what they recognized as positive points for the implementation of childbirth and puerperium humanization: the obstetrics residency program coordination and tutoring team's support; the clear and objective interpersonal relationship with the entire multi-professional team; the institution's physical structure; however, they have also identified as negative points: their acceptance by coworkers in the workplace; the resistance offered by the multi-professional team and the patients; the institutional norms; and the interventionist culture. Conclusion: It is noted that the obstetric nursing residents still need to earn their place in maternity clinics in a more emphatic way, which will enable them greater autonomy, in order to put into practice the implementation of new strategies based on care humanization.

Resumo: Objetivo: descrever as potencialidades e os desafios das residentes sobre a experiência vivenciada em um Programa Nacional de Residência em Enfermagem Obstétrica, no que se refere à humanização do parto e do puerpério. Método: estudo descritivo, exploratório, com abordagem qualitativa, realizado com seis enfermeiras egressas do curso de residência em enfermagem obstétrica de uma universidade pública. Para a coleta de dados, utilizou-se a entrevista semiestruturada, a qual foi analisada pela Técnica de Análise de Conteúdo, na modalidade Análise Temática. Resultados: das reflexões das residentes, por meio das categorias emergentes, pôde-se verificar que estas reconheciam como pontos positivos para a implementação da humanização do parto e do puerpério: o apoio da coordenação e da tutoria do curso de residência obstétrica; o relacionamento interpessoal claro e objetivo com toda a equipe multiprofissional; a estrutura física da Instituição; ao mesmo tempo, identificaram como pontos negativos: a conquista do ambiente; a resistência por parte da equipe multiprofissional e dos pacientes; as normas institucionais; e a cultura intervencionista. Conclusão: Percebe-se que as residentes em enfermagem obstétrica ainda necessitam conquistar seus espaços nas maternidades de maneira mais enfática, o que posssibilitará maior autonomia, com vistas a colocar em prática a implementação de novas estratégias, fundamentadas na humanização do cuidado.

OBJECTIVES: Inflammatory molecules play a role in the development of atherosclerosis, which is the primary origin of cardiovascular disorders. However, to the best of our knowledge, no study has attempted to investigate the relationship between these circulating molecules and the prediction of cardiovascular risk. The present study aimed to investigate the relationships of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin and matrix metalloproteinase 9 serum concentrations with the extent of coronary lesions. METHODS: Seventy-four individuals who were undergoing coronary angiography for the first time for diagnostic purposes were enrolled in this study. The extent of the coronary lesion was assessed using the Friesinger Index, and subjects were classified into four groups: no lesions, minor lesions, intermediate lesions and major lesions. Serum biochemical parameters and serum concentrations of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin and matrix metalloproteinase 9 were analyzed. RESULTS: The vascular cell adhesion molecule-1 concentration was higher than 876 ng/mL in individuals with intermediate and major lesions (p<0.001 and p=0.020, respectively). Moreover, logistic regression analysis showed that these patients had an increased risk of having an intermediate lesion (p=0.007). Interestingly, all individuals with major lesions had vascular cell adhesion molecule-1 concentrations higher than 876 ng/mL. No association was found between the concentrations of the other proteins and the Friesinger Index. CONCLUSIONS: Serum vascular cell adhesion molecule-1 may be associated with the extent of coronary lesions. Moreover, it may represent an alternative to improve the cardiovascular risk classification in patients without acute coronary syndrome.

ABSTRACT Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk development. However, the mechanisms of reduced kidney function with CVD risk are unclear. This study aimed to investigate the association between kidney function and Framingham risk score (FRS) in participants with traditional cardiovascular risk factors and normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² in an admixed population of Brazil. The participants were divided into three groups according to FRS: low risk group with 0% to <10%, moderate risk group with ≥10% to 20% and high risk group with >20%. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Data from participants were collected by questionnaire, and blood and urine samples were collected to analyze biochemical markers. A total of 214 subjects aged 53±10 years old was collected. There were 77 individuals in low risk group, 59 in moderate risk group and 78 in high-risk group. Mean eGFRCKD-EPI was 89.39±15.05 mL/min/1.73 m² and 90.74±16.17 mL/min/1.73 m2 when race adjustment. The results indicated that there is an increasing the cardiovascular risk with a decreased of eGFR, conforming to a significant inverse correlation observed between eGFR and FRS with Spearman correlation (R²=-0.256, p<0.001; R²=-0.224, p=0.001, when adjusted for race). There was a statistically significant difference in eGFRCKD-EPI (p<0.001) and eGFRCKD-EPI with race adjustment (p=0.002) among risk groups. The data suggests that the reduction eGFR is associated with elevated FRS among Brazilian adults without CKD. Furthermore, the results suggest that race adjustment it’s not necessary in Brazilian population.