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ABSTRACT: Clostridioides difficile is a strictly anaerobic, spore-forming Gram-positive bacterium associated with diarrhea, known as C. difficile infection (CDI). In domestic animals, C. difficile is considered an important pathogen mostly in pigs and horses, but there are also reports in other domestic species. In wild animals, the epidemiology of C. difficile is largely unknown, and the role of the bacterium as a cause of diarrhea is unclear. The aim of this study was to determine the prevalence of C. difficile in the feces of wild animals referred to the Center of Medicine and Research in Wild Animals (CEMPAS). Fecal samples obtained from 100 animals of 34 different species were subjected to qPCR for the detection of the C. difficile 16S rRNA gene and two major toxin genes (tcdA and tcdB) and to anaerobic bacterial isolation. A total of 63 animals (63%) were positive for C. difficile by qPCR, and 16 isolates were recovered. The opossum (Didelphis spp.) had the highest number of positive animals in both tests (from 21 samples, 19 were qPCR positive, and four isolates were recovered). Three toxigenic strains (RT 002, 004, and 014), all previously described as infecting humans and animals, were isolated in the following species: bearded dragon (Pogona vitticeps), pampas fox (Lycalopex vetulus), and marmoset (Callithrix sp.). The presence of C. difficile in the feces of wild animals highlights the importance of wildlife as potential carriers of infection for production animals or humans. ABSTRACT sporeforming spore forming Grampositive Gram C CDI. CDI . (CDI) horses unknown unclear CEMPAS. CEMPAS (CEMPAS) 10 3 S tcdA tcdB isolation 6 63% (63% 1 recovered Didelphis spp. spp 2 recovered) RT 002 004 014, 014 , 014) Pogona vitticeps, vitticeps vitticeps) Lycalopex vetulus, vetulus vetulus) Callithrix sp.. sp sp. sp.) (CDI (CEMPAS (63 00 01 (6 0 (

RESUMO: O Clostridioides difficile é uma bactéria Gram-positiva estritamente anaeróbica e formadora de esporos, associada à diarreia e conhecida como infecção por C. difficile (CID). Em animais domésticos, o C. difficile é considerado um patógeno importante principalmente em porcos e cavalos, mas também há relatos em outras espécies domésticas. Em animais selvagens, a epidemiologia do C. difficile é amplamente desconhecida, e o papel da bactéria como causa de diarreia não está claro. O objetivo deste estudo foi determinar a prevalência do C. difficile nas fezes de animais selvagens encaminhados ao Centro de Medicina e Pesquisa em Animais Selvagens (CEMPAS). Amostras de fezes obtidas de 100 animais de 34 espécies diferentes foram submetidas à qPCR para a detecção do gene 16S rRNA do C. difficile e dois principais genes de toxina (tcdA e tcdB), além de isolamento bacteriano anaeróbico. Um total de 63 animais (63%) foram positivos para C. difficile por qPCR, e 16 isolados foram recuperados. O gambá (Didelphis spp.) apresentou o maior número de animais positivos em ambos os testes (de 21 amostras, 19 foram positivas na qPCR, e quatro isolados foram recuperados). Três cepas toxigênicas (RT 002, 004 e 014), todas previamente descritas como infectando humanos e animais, foram isoladas nas seguintes espécies: dragão barbado (Pogona vitticeps), raposa-pampas (Lycalopex vetulus) e sagui (Callithrix sp.). A presença de C. difficile nas fezes de animais selvagens destaca a importância da vida selvagem como potencial portadora de infecção para animais de produção ou seres humanos. RESUMO Grampositiva Gram positiva esporos C CID. CID . (CID) domésticos cavalos domésticas desconhecida claro CEMPAS. CEMPAS (CEMPAS) 10 3 S tcdA tcdB, tcdB , tcdB) anaeróbico 6 63% (63% 1 recuperados Didelphis spp. spp 2 amostras recuperados) RT 002 00 014, 014 014) Pogona vitticeps, vitticeps vitticeps) raposapampas raposa pampas Lycalopex vetulus Callithrix sp.. sp sp. sp.) (CID (CEMPAS (63 0 01 (6 (

https://doi.org/10.1590/1678-5150-pvb-7385

Microporous Nitrogen-Doped Activated Biochars Derived from Corn: Use of Husk Waste and Urea for CO2 Capture NitrogenDoped Nitrogen Doped Corn CO
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Hisse, Danilo

; Bessa, Isabela A. A.

; Silva, Ludmila P. C.

; Silva, Aline F. M. da

; Araujo, Joyce R.

; Archanjo, Bráulio S.

; Soares, André V. H.

; Passos, Fabio B.

; Carneiro, José W. M.

; Santos, Thiago C. dos

; Ronconi, Célia M.

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 11 elocation e-20240034

Resumo: En | Texto: En | PDF: En

The increase in anthropogenic activity over time has led to an exponential increase in greenhouse gas emissions, especially CO2. Proftable technologies for CO2 capture and separation are conspicuous, and porous biochars derived from biomass waste can be a useful solution. Herein, we produced activated nitrogen-doped biochars for CO2 capture from corn husk waste, urea and K2CO3, named N-Bio-X (X = 600, 700, and 800 °C). N-Bio-X exhibited microporosity and different nitrogen contents and thus played an important role in the adsorption of CO2. N-Bio-700 exhibited the highest CO2 adsorption capacity, fastest adsorption kinetics and excellent stability after multiple adsorption-desorption cycles. N-Bio-600 showed excellent CO2/N2 selectivity, induced by nitrogen sites, particularly pyridinic and graphitic nitrogen. The cost-effectiveness of the raw material, coupled with its high adsorption capacity, rapid kinetics, and stable properties, provided highly promising N-doped biochars for practical implementation in CO2 capture and separations in postcombustion processes. emissions CO conspicuous solution Herein nitrogendoped doped K2CO3 KCO K NBioX N Bio X 600 700 80 °C. C °C . °C) NBio700 NBio N-Bio-70 capacity adsorptiondesorption desorption cycles NBio600 N-Bio-60 CO2N2 CON N2 CO2/N selectivity sites costeffectiveness cost effectiveness material properties Ndoped processes K2CO 60 70 8 NBio70 N-Bio-7 NBio60 N-Bio-6 CO2N 6 7 NBio7 N-Bio- NBio6 N-Bio

https://doi.org/10.21577/0103-5053.20240034

OBTENÇÃO DE AMINAS PRIMÁRIAS A PARTIR DA REDUÇÃO DE NITROCOMPOSTOS AROMÁTICOS VIA PROTOCOLOS DE REAÇÕES SUSTENTÁVEIS PARTE II: EM MEIO ORGÂNICO II
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Pinto, Ligia S. da S.

; Facchinetti, Victor

; Bernardes, Breno de S.

; Costa, Thamires M. da

; Silva, Letícia de O. J. L. da

; Macedo, Daniel M.

; Oliveira, Isabela P. de

; Vasconcelos, Thatyana R. A.

; Souza, Marcus Vinícius N. de

Química Nova

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2024, Volume 47 Nº 7 elocation e-20240017

Resumo: Pt | Texto: Pt | PDF: Pt

The reduction of nitroarenes is the main methodology to produce anilines, important precursors of building blocks, dyes, and drugs. Continuing our goal of describing sustainable methodologies for the reduction of nitroarenes to their respective anilines, herein we compile selected reaction protocols, using organic medium, reported from 2017 to 2023, in order to provide a comprehensive and complementary view of the new processes and catalysts developed during this period. anilines blocks dyes drugs protocols medium 201 2023 period 20 202 2

https://doi.org/10.21577/0100-4042.20240017

Novelties to the vascular Flora of the Ibitipoca Mountains, Minas Gerais, Brazil Mountains Gerais
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Toledo, Cássio A. P.

; Souza, Lukas R.

; Diniz, Adriana P.

; Santos, Adrielle J. M.

; Araujo, Carina de

; Graciano, Diego S.

; Arantes, Fabíula M.

; Sabino, Gabriel P.

; Guimarães, Gabriel S.

; Onorato, Geovana de C.

; Andrella, Giovani C.

; Waga, Isabela M.

; Castilho, Jade

; Silva, João P. S.

; Manoel, Laís B.

; Lima, Mariana C. A.

; Araújo, Michelly D. F.

; Feliz, Pablo

; Gaem, Paulo H.

; Luiz, Pedro L.

; Völtz, Rafael R.

; Gerace, Samuele

; Sawakuchi, Sonia

; Ivanauskas, Natália M.

; Koch, Ingrid

; Forzza, Rafaela C.

; Souza, Vinicius C.

; Rodrigues, Ricardo R.

Biota Neotropica

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2024, Volume 24 Nº 2 elocation e20231560

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A Serra do Ibitipoca ocorre no sudeste do estado de Minas Gerais, sudeste do Brasil, e inclui um mosaico de diferentes tipos de vegetação, como parte do domínio da Mata Atlântica. Tal heterogeneidade é resultado da ocorrência de diversos ecótonos na região, considerados áreas de amortecimento essenciais para manutenção da biodiversidade e estrutura de ecossistemas adjacentes. Dada a importância destes ambientes para conservação da biodiversidade, inventários florísticos são importantes para catalogar a riqueza de plantas em áreas naturais, onde espécies e paisagens têm sido destruídas, especialmente nas últimas décadas. Para contribuir com o aumento do conhecimento sobre a Flora vascular na Serra do Ibitipoca, um inventário florístico foi conduzido em áreas privadas adjacentes ao Parque Estadual do Ibitipoca. As descobertas mais relevantes do presente estudo incluem: caracterização dos diferentes tipos de vegetação, 17 novos registros para a Flora de Minas Gerais, coleta de 288 espécies nunca registradas para o parque (80% de dissimilaridade – especialmente devido à ocorrência e tamanho de diferentes fitofisionomias entre as áreas) e presença de 31 espécies ameaçadas. Além disso, discussões sobre esforços para conservação e políticas públicas são apresentadas. Gerais Brasil vegetação Atlântica região naturais destruídas décadas incluem 1 28 80% 80 (80 3 ameaçadas disso apresentadas 2 8 (8 (

Abstract The Ibitipoca Mountains occur in southeastern Minas Gerais state, Southeast Brazil, and includes a mosaic of different vegetation types, as part of the Atlantic Forest domain. Such heterogeneity results in the occurrence of several ecotones in the region, considered essential buffer zones for maintaining biodiversity and structure among adjacent ecosystems. Given the importance of these environments for biodiversity conservation, floristic surveys are important to catalogue plant richness in natural areas, where species and landscapes have been destroyed, especially over the last decades. To contribute to increase the knowledge on the vascular Flora in the Ibitipoca Mountains, a floristic inventory was undertaken in private properties located in the boundaries of “Parque Estadual do Ibitipoca” (Ibitipoca State Park). Relevant findings of the present study include: characterization of the different vegetation types, 17 new records for the Flora of Minas Gerais, collection of 288 species never recorded in the state park (80% dissimilarity – especially due to the occurrence and size of different phytophysiognomies between these areas) and presence of 31 threatened species. In addition, discussions about conservation efforts and public policies are presented. Brazil types domain region ecosystems areas destroyed decades Parque Park. Park . Park) include 1 28 80% 80 (80 3 addition presented 2 8 (8 (

https://doi.org/10.1590/1676-0611-bn-2023-1560

Evaluation of Nitrogen-Doped Adsorbents Based on Reduced Graphene Oxide as Platforms for CO2 Capture NitrogenDoped Nitrogen Doped CO
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Ribeiro, Matheus G.

; Bessa, Isabela A. A.

; Silva, Aline F. M. da

; Ligiero, Carolina B. P

; Osta, Leonardo O.

; Silva, Ludmila P C.

; Araujo, Joyce R.

; Archanjo, Bráulio S.

; Ronconi, Célia M.

; Santos, Thiago C. dos

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 11 elocation e-20240093

Resumo: En | Texto: En | PDF: En

CO2 emissions into the atmosphere have been rapidly rising due to human activities, resulting in the escalation of global warming. To mitigate climate change, it is imperative to develop materials for CO2 capture with high CO2 capacity and low production costs. Herein, we developed a facile method to obtain adsorbents based on reduced graphene oxide (rGO) sheets, NrGO(1 – X)700, where X represents the mass of diethylenetriamine (DETA) (X = 1, 2 and 4 g) used in the preparation. The materials NrGO(1 – 1)700, NrGO (1 – 2)700, and NrGO(1 – 4)700 were obtained from graphene oxide dispersions, followed by DETA impregnation and chemical activation with K2CO3. N2 isotherms demonstrated that the materials simultaneously presented micro and mesopores with similar values of specific surface area (280.16 to 310.32 m2 g–1), pore volume (0.26 to 0.28 cm3 g–1) and pore size (3.78 to 3.80 nm). CO2 sorption experiments revealed that the material NrGO(1 – 4)700, containing the highest amount of pyridinic, graphitic, and amino nitrogen functionalities, showed the best CO2 adsorption capacity. Diffuse reflectance Fourier transformed infrared spectroscopy experiments indicated stronger solid-gas interactions for NrGO(1 – 4)700 than for the other materials. CO activities warming change costs Herein rGO (rGO sheets NrGO1 1 NrGO( X700, X700 700, 700 X)700 (DETA g preparation 1700, 1700 1)700 ( 2700, 2700 2)700 4700 4)70 dispersions K2CO3 KCO K N 280.16 28016 280 16 (280.1 31032 310 32 310.3 m g–1, g1 g–1 , 0.26 026 0 26 (0.2 028 28 0.2 cm 3.78 378 3 78 (3.7 380 80 3.8 nm. nm . nm) 4700, pyridinic graphitic functionalities solidgas solid gas X70 70 X)70 170 1)70 270 2)70 470 4)7 K2CO 280.1 2801 (280. 3103 31 310. g– 02 (0. 0. 3.7 37 7 (3. 38 8 3. X7 X)7 17 1)7 27 2)7 47 4) 280. (280 (0 (3 X) 1) 2) (28 (2

https://doi.org/10.21577/0103-5053.20240093

Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023 202 20 2
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Rassi, Daniela do Carmo

; Bragança, Érika Olivier Vilela

; Moura, Lidia Zytynski

; Arrais, Magaly

; Campos, Milena dos Santos Barros

; Lemke, Viviana Guzzo

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Almeida, André Luiz Cerqueira de

; Brandão, Andréa Araujo

; Ferreira, Andrea Dumsch de Aragon

; Biolo, Andreia

; Macedo, Ariane Vieira Scarlatelli

; Falcão, Breno de Alencar Araripe

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Claudia Maria Vilas

; Pellegrini, Denise

; Alexandre, Elizabeth Regina Giunco

; Braga, Fabiana Goulart Marcondes

; Oliveira, Fabiana Michelle Feitosa de

; Cintra, Fatima Dumas

; Costa, Isabela Bispo Santos da Silva

; Silva, José Sérgio Nascimento

; Carreira, Lara Terra F.

; Magalhães, Lucelia Batista Neves Cunha

; Matos, Luciana Diniz Nagem Janot de

; Assad, Marcelo Heitor Vieira

; Barbosa, Marcia M.

; Silva, Marconi Gomes da

; Rivera, Maria Alayde Mendonça

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Paiva, Maria Sanali Moura de Oliveira

; Castro, Marildes Luiza de

; Uellendahl, Marly

; Oliveira Junior, Mucio Tavares de

; Souza, Olga Ferreira de

; Costa, Ricardo Alves da

; Coutinho, Ricardo Quental

; Silva, Sheyla Cristina Tonheiro Ferro da

; Martins, Sílvia Marinho

; Brandão, Simone Cristina Soares

; Buglia, Susimeire

; Barbosa, Tatiana Maia Jorge de Ulhôa

; Nascimento, Thais Aguiar do

; Vieira, Thais

; Campagnucci, Valquíria Pelisser

; Chagas, Antonio Carlos Palandri

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 7 elocation e20230303

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20230303

Nontuberculous mycobacteria in patients of a specialty hospital
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Barboza, Grazielle Conceição Sousa

; Almeida, Isabela Neves de

; Santos, Lucas Benício dos

; Augusto, Claudio José

; Leal, Élida Aparecida

; Pádua, Cristiane Aparecida Menezes de

; Cesar, Aina Liz Alves

; Kritski, Afrânio Lineu

; Carvalho, Wânia da Silva

; Miranda, Silvana Spíndola de

; Figueredo, Lida Jouca de Assis

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e42

Resumo: En | Texto: En | PDF: En

ABSTRACT The incidence and clinical characteristics of NTM diseases in Brazil remain relatively unknown. The present study describes the diagnosis of NTM isolates, the clinical presentation and treatment outcomes. We analyzed NTM isolates in patients of a tertiary hospital in the Southeast region of Brazil, from January 2008 to July 2019. The ATS/IDSA criteria for diagnosis and treatment of these patients was applied. Mycobacterium kansasii were identified in 13/113 (11.5%) patients. In 59/113 (52.2%) patients who met the ATS criteria for disease, 29/59 (49.1%) received treatment, and 22/29 (75.8%) were cured. The major species identified was M. kansasii. The most frequent symptoms among the treated patients were dyspnea and cough, and the proportion of cured patients was high. unknown outcomes 200 2019 ATSIDSA IDSA applied 13113 13 113 13/11 11.5% 115 11 5 (11.5% 59113 59 59/11 52.2% 522 52 2 (52.2% disease 2959 29 29/5 49.1% 491 49 1 (49.1% 2229 22 22/2 75.8% 758 75 8 (75.8% M cough high 20 201 1311 13/1 11.5 (11.5 5911 59/1 52.2 (52.2 295 29/ 49.1 4 (49.1 222 22/ 75.8 7 (75.8 131 13/ 11. (11. 591 59/ 52. (52. 49. (49. 75. (75. (11 (52 (49 (75 (1 (5 (4 (7 (

https://doi.org/10.1590/s1678-9946202365042

Association between psoriasis and thyroid function: results from the Brazilian Longitudinal Study of Adults Health (ELSA-Brasil) function ELSABrasil ELSA Brasil (ELSA-Brasil
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Meneghini, Vandrize

; Tebar, William R.

; Santos, Itamar Souza

; Janovsky, Carolina Castro Porto Silva

; Almeida-Pititto, Bianca de

; Lotufo, Paulo A.

; Goulart, Alessandra C.

; Bensenor, Isabela M.

Archives of Endocrinology and Metabolism

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2023, Volume 67 Nº 6 elocation e000640

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To determine the relationship between psoriasis, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), and subclinical thyroid dysfunctions in middle-aged and older adults. Materials and methods: Cross-sectional analyses included a self-reported medical diagnosis of psoriasis and thyroid function from the 3rd visit (2017-2019) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). TSH, FT4, and FT3 levels were analyzed as continuous variables and quintiles, and TPOAb positivity and subclinical hypothyroidism as a yes/no variable. Logistic regression models were built as crude and adjusted by main confounders (age, sex, education level, race/ethnicity, and smoking). Results: From 9,649 participants (52.3% women; 59.2 ± 8.7 years old), the prevalence of psoriasis was 2.8% (n = 270). TSH, FT4, TPOAb positivity, and subclinical hypothyroidism were not associated with psoriasis in the main analyses. In the stratified analysis, our findings showed positive associations of the lowest (OR = 2.01; 95% CI 1.05-3.84; p = 0.036) and the highest (OR = 2.13; 95% CI 1.12-4.05; p = 0.022) quintiles of FT4 and a protective association of TPOAb positivity (OR = 0.43; 95% CI 0.19-0.98; p = 0.046) with prevalent psoriasis in women. In the logistic regression for FT3, participants in the 1st quintile showed a statistically significant association with psoriasis for the whole sample (OR = 1.66; 95% CI 1.11-2.46; p = 0.013) and for men (OR = 2.25; 95% CI 1.25-4.04; p = 0.007) in the sex-stratified analysis. Conclusions: The present study showed that the association of FT4 levels with psoriasis are different according to sex, with a possible U-shaped curve in women but not in men. Although there were some associations of FT3 with psoriasis, they may be a consequence of non-thyroidal illness syndrome. Further prospective data may clarify the association of thyroid function and psoriasis. Objective thyroidstimulating stimulating TSH , (TSH) FT (FT4) (FT3) TPOAb, (TPOAb) middleaged middle aged adults methods Crosssectional Cross sectional selfreported self reported rd 20172019 2017 2019 (2017-2019 ELSABrasil. ELSABrasil ELSA Brasil . (ELSA-Brasil) yesno yes no variable age, age (age sex level raceethnicity race ethnicity race/ethnicity smoking. smoking smoking) Results 9649 9 649 9,64 52.3% 523 52 3 (52.3 592 59 2 59. 87 8 7 8. old, old old) 28 2.8 n 270. 270 270) analysis OR 2.01 201 01 95 1.053.84 105384 1.05 3.84 1 05 84 1.05-3.84 0.036 0036 0 036 2.13 213 13 1.124.05 112405 1.12 4.05 12 4 1.12-4.05 0.022 0022 022 0.43 043 43 0.190.98 019098 0.19 0.98 19 98 0.19-0.98 0.046 0046 046 st 1.66 166 66 1.112.46 111246 1.11 2.46 11 46 1.11-2.46 0.013 0013 013 2.25 225 25 1.254.04 125404 1.25 4.04 04 1.25-4.04 0.007 0007 007 sexstratified Conclusions Ushaped U shaped nonthyroidal non thyroidal syndrome (TSH (FT4 (FT3 (TPOAb 2017201 (2017-201 (ELSA-Brasil 964 64 9,6 52.3 5 (52. 2. 27 2.0 20 053 1.053.8 10538 105 1.0 384 3.8 1.05-3.8 0.03 003 03 2.1 21 124 1.124.0 11240 112 1.1 405 4.0 1.12-4.0 0.02 002 02 0.4 190 0.190.9 01909 019 0.1 098 0.9 0.19-0.9 0.04 004 1.6 16 6 1.112.4 11124 111 246 2.4 1.11-2.4 0.01 001 2.2 22 254 1.254.0 12540 125 1.2 404 1.25-4.0 0.00 000 00 (FT 201720 (2017-20 96 9, 52. (52 1.053. 1053 10 1. 38 3. 1.05-3. 0.0 1.124. 1124 40 4. 1.12-4. 0. 0.190. 0190 09 0.19-0. 1.112. 1112 24 1.11-2. 1.254. 1254 1.25-4. 20172 (2017-2 (5 1.053 1.05-3 1.124 1.12-4 0.190 0.19-0 1.112 1.11-2 1.254 1.25-4 (2017- ( 1.05- 1.12- 0.19- 1.11- 1.25- (2017 (201 (20 (2

https://doi.org/10.20945/2359-3997000000640

The association of diabetes, subclinical hypothyroidism and carotid intima-media thickness: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil) diabetes intimamedia intima media thickness ELSABrazil ELSA Brazil (ELSA-Brazil
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Spilack, Aída de Melo

; Goulart, Alessandra C.

; Almeida-Pititto, Bianca de

; Janovsky, Carolina Castro Porto Silva

; Lotufo, Paulo A.

; Santos, Itamar de Souza

; Benseñor, Isabela M.

Clinics

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2023, Volume 78 elocation 100154

Resumo: En | Texto: En | PDF: En

Abstract Introduction: The association of diabetes with subclinical thyroid diseases may increase the risk of cardiovascular diseases. We analyzed the association of subclinical hypothyroidism, diabetes, and both diseases with carotid Intima-Media Thickness (cIMT) as a surrogate maker for early cardiovascular disease in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: Cross-sectional analysis with data from the 3rd visit (2017‒2019). Linear regression models were used to evaluate the association of subclinical hypothyroidism, diabetes and of both diseases with a cIMT presented as Beta (95% Confidence Interval – 95% CI) without adjustment, with adjustment for sociodemographic variables (Model 1) and multivariable adjustment (Model 1 more cardiovascular risk factors). We also used logistic regression models to analyze the Odds Ratio (OR) and 95% CI for the association of both diseases using cIMT > P75%. Results: After the exclusion of patients with previous cardiovascular disease, 5,077 participants with no diseases, 1578 with diabetes, 662 with subclinical hypothyroidism, and 234 with both diseases were included in the analysis. Linear regression models showed an association of cIMT with only diabetes (β = 0.019; 95% CI 0.012 to 0.027; p < 0.0001) and subclinical hypothyroidism more diabetes (β = 0.03; 95% CI 0.010‒0.047, p < 0.0001). The logistic regression model reported an association between diabetes and CIMT higher than P75% (OR = 1.49, 95% CI 1.30‒1.71). No interaction between diabetes and subclinical hypothyroidism was detected using cIMT respectively as a continuous (p = 0.29) or as a categorical variable (p = 0.92). Discussion: Diabetes was associated with higher cIMT values. However, no additive effect of subclinical hypothyroidism associated with diabetes over cIMT was detected. Introduction IntimaMedia Intima Media (cIMT ELSABrasil. ELSABrasil ELSA Brasil . (ELSA-Brasil) Methods Crosssectional Cross sectional rd 2017‒2019. 20172019 2017‒2019 2017 2019 (2017‒2019) 95 (95 Model factors. factors factors) OR P75 P Results 5077 5 077 5,07 157 66 23 β 0.019 0019 0 019 0012 012 0.01 0.027 0027 027 0.0001 00001 0001 0.03 003 03 00100047 010 047 0.010‒0.047 0.0001. 149 49 1.49 1.30‒1.71. 130171 1.30‒1.71 30 71 1.30‒1.71) 0.29 029 29 0.92. 092 0.92 92 0.92) Discussion values However (ELSA-Brasil 2017201 2017‒201 201 (2017‒2019 9 (9 P7 507 07 5,0 15 6 2 001 01 0.0 0.02 002 02 0.000 0000 000 00 0010004 04 0.010‒0.04 14 4 1.4 13017 1.30‒1.7 3 7 0.2 09 0.9 201720 2017‒20 20 (2017‒201 ( 50 5, 0. 0.00 001000 0.010‒0.0 1. 1301 1.30‒1. 20172 2017‒2 (2017‒20 00100 0.010‒0. 130 1.30‒1 2017‒ (2017‒2 0010 0.010‒0 13 1.30‒ (2017‒ 0.010‒ 1.30 (2017 0.010 1.3 (201 (20 (2

https://doi.org/10.1016/j.clinsp.2022.100154

10.

Posicionamento sobre a Saúde Cardiovascular nas Mulheres – 2022 202 20 2
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Oliveira, Glaucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Marques-Santos, Celi

; Costa, Maria Elizabeth Navegantes Caetano

; Carvalho, Regina Coeli Marques de

; Freire, Cláudia Maria Vilas

; Magalhães, Lucelia Batista Neves Cunha

; Hajjar, Ludhmila Abrahão

; Rivera, Maria Alayde Mendonça

; Castro, Marildes Luiza de

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Brandão, Andréa Araujo

; Macedo, Ariane Vieira Scarlatelli

; Lantieri, Carla Janice Baister

; Polanczyk, Carisi Anne

; Albuquerque, Carlos Japhet da Matta

; Born, Daniel

; Falcheto, Eduardo Belisário

; Bragança, Érika Olivier Vilela

; Braga, Fabiana Goulart Marcondes

; Colombo, Fernanda M. Consolim

; Jatene, Ieda Biscegli

; Costa, Isabela Bispo Santos da Silva

; Rivera, Ivan Romero

; Scholz, Jaqueline Ribeiro

; Melo Filho, José Xavier de

; Santos, Magaly Arrais dos

; Izar, Maria Cristina de Oliveira

; Azevedo, Maria Fátima

; Moura, Maria Sanali

; Campos, Milena dos Santos Barros

; Souza, Olga Ferreira de

; Medeiros, Orlando Otávio de

; Silva, Sheyla Cristina Tonheiro Ferro da

; Rizk, Stéphanie Itala

; Rodrigues, Thais de Carvalho Vieira

; Salim, Thaís Rocha

; Lemke, Viviana de Mello Guzzo

Arquivos Brasileiros de Cardiologia

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Nov 2022, Volume 119 Nº 5 Páginas 815 - 882

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20220734

11.

Evidências e lacunas na produção científica sobre os gestores do SUS: Scoping review
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Castro, Janete Lima de

; Magnago, Carinne

; Ribeiro, Samara da Silva

; Belisário, Soraya Almeida

; França, Tania

; Pinto, Isabela Cardoso M.

New Trends in Qualitative Research

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Set 2022, Volume 13 elocation e699

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo. Introdução: Hipotetizamos que há lacunas no conhecimento sobre os gestores do Sistema Único de Saúde (SUS) e que o termo gestor é utilizado para designar diferentes atores. Objetivo: Mapear a produção científica e sintetizar as evidências sobre os gestores do SUS a partir de uma scoping review. Método: Scoping review orientada pelo PRISMA-ScR. A abordagem 'população, conceito, contexto' foi seguida para a formulação da questão de pesquisa: Quais as características das publicações e as principais evidências científicas sobre os gestores do SUS? Estudos foram buscados em bases de literatura científicas a partir da combinação de 53 termos. A seleção foi realizada pela leitura de títulos, resumos e métodos, seguida pela leitura integral analítica. Os dados foram submetidos a técnicas usuais de análise estatística descritiva e de análise de conteúdo. Resultados: 51 publicações foram analisadas. Observou-se predominância de estudos qualitativos realizados com gestores municipais das regiões Sul e Sudeste. Foram descobertas evidências sobre o perfil, atribuições e atributos do gestor e, em menor proporção, sobre as percepções dos gestores sobre a sua função. Conclusões: Verificou-se usos diferenciados do termo gestor, número reduzido de estudos que tomam os gestores do SUS como foco de análise, e escassez de evidências sobre gestores estaduais e federais. A scoping review mostrou-se método útil e rigoroso para o mapeamento de evidências e a identificação de lacunas no conhecimento.

Abstract. Introduction: We hypothesized that there are gaps in knowledge about the managers of the Unified Health System (SUS) and that the term manager is used to designate different actors. Objective: To map the scientific production and synthesize the evidence on SUS managers from a scoping review. Method: Scoping review guided by PRISMA-ScR. The 'population, concept, context' approach was followed to formulate the research question: What are the characteristics of publications and the main scientific evidence on SUS managers? Studies were searched in scientific literature bases from the combination of 53 terms. Selection was performed by reading titles, abstracts, and methods, followed by full analytical reading. The data were submitted to the usual techniques of descriptive statistical analysis and content analysis. Results: 51 publications were analyzed. There was a predominance of qualitative studies carried out with municipal managers in the South and Southeast regions. Evidence was found on the profile, attributions, and attributes of the manager and, to a lesser extent, on the perceptions of managers about their role. Conclusions: There were different uses of the term manager, a reduced number of studies that take SUS managers as the focus of analysis, and scarcity of evidence on state and federal managers. The scoping review proved to be a useful and rigorous method for mapping evidence and identifying gaps in knowledge.

https://doi.org/10.36367/ntqr.13.2022.e699

12.

Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
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Bensenor, Isabela M.

; Goulart, Alessandra C.

; Pereira, Alexandre C.

; Brunoni, André R.

; Alencar, Airlane

; Santos, Raul D.

; Bittencourt, Márcio S.

; Telles, Rosa W.

; Machado, Luciana Andrade Carneiro

; Barreto, Sandhi Maria

; de Almeida-Pititto, Bianca

; Janovsky, Carolina Porto Silva

; Sgarbi, José Augusto

; Tebar, William R.

; Meneghini, Vandrize

; Barbosa Junior, Fernando

; Ribeiro, Ana Cristina de Medeiros

; Pasoto, Sandra Gofinet

; Pereira, Rosa Maria R.

; Bonfá, Eloísa

; Sipahi, Aytan M.

; Santos, Itamar de S.

; Lotufo, Paulo A.

Clinics

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2022, Volume 77 elocation 100013

Resumo: En | Texto: En | PDF: En

Abstract Objectives This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.

https://doi.org/10.1016/j.clinsp.2022.100013

13.

A first report of decapod crustaceans (Anomura and Brachyura) from Laje de Santos: a no-take marine reserve in the southeast coast of Brazil
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Moraes, Isabela R. R.

; Davanso, Thiago M.

; Silva, Alexandre R. da

; Cobo, Valter J.

; Alves, Douglas F. R.

; Santana, William

; Mantelatto, Fernando L.

; Castilho, Antonio L.

Revista mexicana de biodiversidad

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2022, Volume 93 elocation e933658

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Este estudio representa un esfuerzo sin precedentes para evaluar la diversidad de los decápodos Brachyura y Anomura del infralitoral rocoso del Parque Estatal Marino Laje de Santos, un área preservada y protegida localizada en la costa sureste de Brasil. Las muestras se tomaron trimestralmente durante 1 año con la combinación de sustrato de refugio artificial para captura pasiva y buceo autónomo para captura activa. Se determinaron un total de 987 individuos distribuidos en 32 especies, 22 géneros y 11 familias. Presentamos un reporte taxonómico de las especies y se discuten sus registros de distribución. El ermitaño Pagurus brevidactylus y el cangrejo Mithraculus forceps fueron las especies más abundantes de Anomura y Brachyura, respectivamente. Como se esperaba, la combinación de los métodos de muestreo mostró un valor más alto del índice de diversidad de Shannon (H = 5.7) que los métodos individuales de captura pasiva (H = 5.6) y captura activa (H = 4.4). Este estudio provee el primer reporte de crustáceos decápodos para el parque, por lo tanto, puede ser usado como línea base para programas de monitoreo de fauna local y en los planes de conservación.

Abstract This study represents an unprecedented effort to assess the diversity of rocky infralittoral decapods Brachyura and Anomura from the Marine State Park of Laje de Santos, a preserved and protected area located in the southeastern Brazilian coast. Sampling was carried out quarterly for 1 year, using the combination of artificial refuge substrate (ARS) for the passive capture of specimens, and SCUBA diving for active capture. A total of 987 individuals distributed into 32 species, 22 genera, and 11 families were determined. We present a taxonomic account of the species and their distribution records are discussed. The hermit crab Pagurus brevidactylus and the crab Mithraculus forceps were the most common species of Anomura and Brachyura, respectively. As expected, the combination of the sampling methodologies showed a higher Shannon diversity index value (H = 5.7), than the individual methods of ARS (H = 5.6) and active capture (H = 4.4). This study provides the first record of decapod crustaceans for the park, therefore it can be used as a baseline for local fauna monitoring programs and conservation planning.

https://doi.org/10.22201/ib.20078706e.2022.93.3658 36 downloads

14.

Incidence of TPOAb over a 4-year follow-up period: results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
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Benseñor, Isabela M.

; Janovsky, Carolina Castro Porto Silva

; Goulart, Alessandra C.

; Santos, Itamar de Souza

; Diniz, Maria de Fátima Haueisen Sander

; Almeida-Pititto, Bianca de

; Sgarbi, José Augusto

; Lotufo, Paulo A.

Archives of Endocrinology and Metabolism

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Dez 2021, Volume 65 Nº 6 Páginas 832 - 840

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Although some previous data have suggested a high iodine intake in Brazil, the prevalence of antithyroperoxidase antibodies (TPOAb) in the country is compatible with rates from countries with adequate iodine intake. This observation emphasizes the importance of knowing the incidence of TPOAb in Brazil. Materials and methods: This prospective analysis included euthyroid participants with negative TPOAb at baseline and a thyroid function assessment at a 4-year follow-up. TPOAb was measured by electrochemiluminescence and considered positive when titers were ≥34 IU/mL. TSH and free T4 (FT4) levels were determined by a third-generation immunoenzymatic assay. The incidence of TPOAb is expressed in percentage per year or as a cumulative incidence within the 4-year follow-up period. Results: Of 8,922 euthyroid participants (mean age 51.1 years; 50.9% women) with a negative TPOAb test at baseline, 130 presented incident TPOAb at the 4-year follow-up, yielding an annual incidence of TPOAb of 0.38%/year (95% confidence interval [95% CI], 0.37-0.39%/year) and a cumulative incidence over 4 years of 1.46% (95% CI, 1.21-1.71%). In men, the annual incidence was 0.32% (95% CI, 0.31-0.33%), and the cumulative incidence over 4 years was 1.23% (95% CI, 0.90-1.56%). In women, the annual incidence was 0.43%/year (95% CI, 0.42-0.44%/year) and the cumulative incidence over 4 years was 1.67% (95% CI, 1.30-2.04%). The only factor associated with incident TPOAb was the occurrence of thyroid diseases at follow-up. No differences in TPOAb incidence were detected across ELSA-Brasil research centers. Conclusion: Based on the results of this study, the incidence of TPOAb per year and at a 4-year follow-up period are compatible with those of a country with adequate iodine intake.

https://doi.org/10.20945/2359-3997000000422 2 downloads

15.

Posicionamento Brasileiro sobre o Uso da Multimodalidade de Imagens na Cardio-Oncologia – 2021
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Melo, Marcelo Dantas Tavares de

; Paiva, Marcelo Goulart

; Santos, Maria Verônica Câmara

; Rochitte, Carlos Eduardo

; Moreira, Valéria de Melo

; Saleh, Mohamed Hassan

; Brandão, Simone Cristina Soares

; Gallafrio, Claudia Cosentino

; Goldwasser, Daniel

; Gripp, Eliza de Almeida

; Piveta, Rafael Bonafim

; Silva, Tonnison Oliveira

; Santo, Thais Harada Campos Espirito

; Ferreira, Waldinai Pereira

; Salemi, Vera Maria Cury

; Cauduro, Sanderson A.

; Barberato, Silvio Henrique

; Lopes, Heloísa M. Christovam

; Pena, José Luiz Barros

; Rached, Heron Rhydan Saad

; Miglioranza, Marcelo Haertel

; Pinheiro, Aurélio Carvalho

; Vrandecic, Bárbara Athayde Linhares Martins

; Cruz, Cecilia Beatriz Bittencourt Viana

; Nomura, César Higa

; Cerbino, Fernanda Mello Erthal

; Costa, Isabela Bispo Santos da Silva

; Coelho Filho, Otavio Rizzi

; Carneiro, Adriano Camargo de Castro

; Burgos, Ursula Maria Moreira Costa

; Fernandes, Juliano Lara

; Uellendahl, Marly

; Calado, Eveline Barros

; Senra, Tiago

; Assunção, Bruna Leal

; Freire, Claudia Maria Vilas

; Martins, Cristiane Nunes

; Sawamura, Karen Saori Shiraishi

; Brito, Márcio Miranda

; Jardim, Maria Fernanda Silva

; Bernardes, Renata Junqueira Moll

; Diógenes, Tereza Cristina

; Vieira, Lucas de Oliveira

; Mesquita, Claudio Tinoco

; Lopes, Rafael Willain

; Segundo Neto, Elry Medeiros Vieira

; Rigo, Letícia

; Marin, Valeska Leite Siqueira

; Santos, Marcelo José

; Grossman, Gabriel Blacher

; Quagliato, Priscila Cestari

; Alcantara, Monica Luiza de

; Teodoro, José Aldo Ribeiro

; Albricker, Ana Cristina Lopes

; Barros, Fanilda Souto

; Amaral, Salomon Israel do

; Porto, Carmen Lúcia Lascasas

; Barros, Marcio Vinícius Lins

; Santos, Simone Nascimento dos

; Cantisano, Armando Luís

; Petisco, Ana Cláudia Gomes Pereira

; Barbosa, José Eduardo Martins

; Veloso, Orlando Carlos Glória

; Spina, Salvador

; Pignatelli, Ricardo

; Hajjar, Ludhmilla Abrahão

; Kalil Filho, Roberto

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Vieira, Marcelo Luiz Campos

; Almeida, André Luiz Cerqueira

Arquivos Brasileiros de Cardiologia

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Out 2021, Volume 117 Nº 4 Páginas 845 - 909

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20200266 103 downloads

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