Resumen El estudio “Letramento e Identidades Sociales: una propuesta etnográfica crítica para la lectura y la escritura para (y con) adultos y adultos mayores en el Pôr do Sol-Ceilândia (DF)” fue realizado entre 2015 y 2017, considerando las demandas sociales de lectura y escritura de los residentes de esta región Administrativa de Brasilia. Durante la búsqueda, se utilizaron diversos instrumentos de investigación tales como: entrevistas semiestructuradas, notas de campo, grupos focales y observaciones a participantes. Para ayudarnos en el análisis, recurrimos a Street (1984), Kleiman (1995, 2012), Ríos (1998), Barton y Hamilton (1998), Gee (2000) y Soares y Pedroso (2016). Se observó al final del proyecto que el proceso de letramento se consolidó, pues todos los participantes estaban alfabetizados y ya eran capaces de realizar diversas actividades en su vida diaria, además de participación social, mayor autonomía en sus actividades diarias y una reconstrucción de sus identidades sociales.

Abstract The study “Literacies and Social Identities: a critical ethnographic proposal for reading and writing for (and with) adults and elderly people from Pôr do Sol - Ceilândia (DF)” was carried out between 2015 and 2017, considering the social demands of reading and writing of the residents of this Administrative Region of Brasília. During the research, were used various research instruments, such as: semi-structured interviews, field notes, focus groups and participant observations. To assist in the analyses, the following references were utilized: Street (1984), Kleiman (1995, 2012), Ríos (1998), Barton y Hamilton (1998), Gee (2000) y Soares y Pedroso (2016). At the end of the project, it was observed that the literacy process was consolidated, as all project participants had been literate and were already capable of carrying out diversified activities in their daily lives. Additionally, noteworthy were increased social participation, greater autonomy in their daily activities, and a reconstruction of their social identities.

Abstract Slabs with cast-in-place steel formwork are composite structural elements composed of concrete and steel. The horizontal shear failure mode is the most common in composite slabs based on numerous experimental studies. This failure mode consists of loss of adherence and mechanical contact at the interface of the composite system and often occurs before the system reaches its full bending capacity. Thus, the design of this constructive system is determined by the value of the longitudinal shear strength, which can be computed by the semi-empirical so-called traditional m-k method based on the four-point bending test proposed by several standards. One of the most known factors to influence the longitudinal shear strength is the geometry of embossments present in the steel work. Calibrated computational simulation using the finite element method can be an alternative way to simulate this type of test. The present work modified and adapted a methodology explicitly including the geometry of embossments in the analysis in order to use materials and products with characteristics available to structural engineers in Brazil and used this methodology to derive m-k coefficients. This is being made with the objective of numerically simulating the effect of relevant parameters for determining the longitudinal shear strength at the concrete-steel interface of composite slabs. Force versus slip, force versus displacement graphs were obtained and the m-k coefficient values found were compared with those of other authors in the literature. The simulations presented values consistent with the literature and in relation to the rupture mode by longitudinal shear, the numerical simulations performed presented ultimate strengths with goodness-of-fit measured by the conventional coefficient of determination, reaching a good value for the semi-empirical relation using the results of the finite element data. castinplace cast place studies capacity Thus semiempirical semi empirical socalled so called mk m k fourpoint four point standards coefficients concretesteel slip goodnessoffit goodness fit determination data

Resumo Lajes com fôrmas metálicas utilizadas durante a concretagem são um sistema estrutural misto composto de aço e concreto. O modo de falha por cisalhamento horizontal é o mais comum em lajes mistas com bases em numerosos estudos experimentais. Esta falha consiste na perda de aderência e contato mecânico do sistema misto e, frequentemente, ocorre antes do sistema atingir sua capacidade máxima à flexão plástica. Assim, o projeto deste sistema construtivo é determinado pela sua resistência ao cisalhamento longitudinal, que pode ser determinada pelo método semiempírico convencional m-k com base no ensaio de flexão de quatro pontos proposto por diversas normas. Um dos fatores conhecidos de maior influência na resistência ao cisalhamento longitudinal é a geometria das mossas presentes na fôrma metálica. Simulações computacionais por meio do método dos elementos finitos calibradas com base em resultados experimentais podem ser uma alternativa à realização deste tipo de ensaio. O presente trabalho modificou e adaptou uma metodologia que inclui explicitamente a geometria das mossas na análise de modo a usar materiais e produtos com características disponíveis para os engenheiros estruturais do Brasil e usou esta metodologia para derivar coeficientes m-k. Isto foi feito com o objetivo de simular numericamente o efeito de parâmetros relevantes para determinar a resistência ao cisalhamento longitudinal na interface aço-concreto de lajes mistas. Gráficos de força versus deslocamentos foram obtidos e os valores dos coeficientes m-k foram comparados com aqueles de outros autores na literatura. As simulações apresentaram valores consistentes com a literatura e, em relação ao modo de ruptura por cisalhamento longitudinal, as simulações numéricas realizadas apresentaram resistências últimas com bom ajuste medido pelo coeficiente de determinação convencional chegando a um valor bom para a relação semiempírica utilizando os resultados dos dados de elementos finitos. concreto frequentemente plástica Assim mk m k normas metálica mk. k. açoconcreto

Abstract Difficult airway management in pediatrics during anesthesia represents a major challenge, requiring a careful approach, advanced technical expertise, and accurate protocols. The task force of the Brazilian Society of Anesthesiology (SBA) presents a report containing updated recommendations for the management of difficult airways in children and neonates. These recommendations have been developed based on the consensus of a panel of experts, with the objective of offering strategies to overcome challenges during airway management in pediatric patients. Grounded in evidence published in international guidelines and expert opinions, the report highlights crucial steps for the appropriate management of difficult airways in pediatrics, encompassing assessment, preparation, positioning, pre-oxygenation, minimizing trauma, and, paramountly, the maintenance of arterial oxygenation. The report also delves into additional strategies involving the use of advanced tools, such as video laryngoscopy, flexible intubating bronchoscopy, and supraglottic devices. Emphasis is placed on the simplicity of implementing the outlined recommendations, with a focus on the significance of continuous education, training through realistic simulations, and familiarity with the latest available technologies. These practices are deemed essential to ensure procedural safety and contribute to the enhancement of anesthesia outcomes in pediatrics. challenge approach expertise protocols SBA (SBA neonates experts patients opinions assessment preparation positioning preoxygenation, preoxygenation pre oxygenation, oxygenation pre-oxygenation trauma paramountly tools laryngoscopy bronchoscopy devices education simulations technologies

ABSTRACT Objective: To know the profile of trabeculectomy, in addition to the success rate in controlling intraocular pressure in patients with glaucoma. Methods: A retrospective, observational study, with medical records of patients with glaucoma, followed up at an ophthalmological reference center, who underwent trabeculectomy from January 1, 2016 to May 31, 2017, by a single experienced surgeon. The success rate was considered with an intraocular pressure < 21 mmHg, for high intraocular pressure glaucoma, and a reduction of at least 20% for normal intraocular pressure glaucoma. Results: We analyzed 160 eyes, among which the majority (63.1%) were female, and 46.25% were aged between 61 and 80 years. There was a predominance of primary open-angle glaucoma in 67.3% of cases, and most were in an advanced stage (91.9%). After performing trabeculectomy, in 39.4% of the eyes, interventions were required at some point in the postoperative period; however, when comparing the groups that presented, or not, these procedures, the evolution of intraocular pressure showed no statistically significant difference. The postoperative period follow-up showed that the intraocular pressure remained below 21 mmHg and with reductions greater than 40% of the baseline intraocular pressure value. Conclusion: The success rate of trabeculectomy exceeded 90%, with a small rate of complications, noting that trabeculectomy is a safe procedure with significant success in the glaucoma control in the state of Ceará. Objective Methods retrospective study center 1 201 31 2017 surgeon 2 20 Results 16 eyes 63.1% 631 63 (63.1% female 4625 46 25 46.25 6 8 years openangle open angle 673 67 3 67.3 cases 91.9%. 919 91.9% . 91 9 (91.9%) 394 39 4 39.4 however presented not procedures difference followup follow 40 value Conclusion 90 90% complications Ceará 63.1 (63.1 462 46.2 67. 91.9 (91.9% 39. 63. (63. 46. 91. (91.9 (63 (91. (6 (91 ( (9

RESUMO Objetivo: Conhecer o perfil da trabeculectomia e a taxa de sucesso no controle da pressão intraocular em pacientes com glaucoma. Métodos: Estudo retrospectivo, do tipo observacional, com prontuários de portadores de glaucoma de um centro de referência oftalmológica que realizaram a trabeculectomia de 1º de janeiro de 2016 a 31 de maio de 2017, por um único cirurgião experiente. A taxa de sucesso foi considerada como uma pressão intraocular < 21 mmHg, para glaucoma de pressão intraocular elevada, e uma redução de pelo menos 20% para glaucoma de pressão intraocular normal. Resultados: Foram analisados 160 olhos, entre os quais a maioria pertencia ao sexo feminino, e 46,25% estavam na faixa etária de 61 a 80 anos. Houve predominância do glaucoma primário de ângulo aberto (67,3% dos casos), e a maioria estava em estágio avançado (91,9%). Após a realização da trabeculectomia, em 39,4% dos olhos foram necessárias intervenções em algum momento do pós-operatório. Contudo, ao comparar os grupos que apresentaram ou não esses procedimentos, a evolução da pressão intraocular não apresentou diferença estatisticamente significativa. No pós-operatório, a pressão intraocular manteve-se abaixo de 21 mmHg e com reduções superiores a 40% do valor da pressão intraocular basal. Conclusão: A taxa de sucesso da trabeculectomia ultrapassou 90%, com pequeno índice de complicações, constatando que a trabeculectomia é um procedimento seguro e com relevante sucesso no controle do glaucoma no estado do Ceará. Objetivo Métodos retrospectivo observacional º 201 3 2017 experiente 2 elevada 20 normal Resultados 16 feminino 4625 46 25 46,25 6 8 anos 67,3% 673 67 (67,3 casos, casos , casos) 91,9%. 919 91,9% . 91 9 (91,9%) 394 39 4 39,4 pósoperatório. pósoperatório pós operatório. operatório pós-operatório Contudo procedimentos significativa pósoperatório, operatório, mantevese manteve se 40 basal Conclusão 90 90% complicações Ceará 1 462 46,2 67,3 (67, 91,9 (91,9% 39, 46, 67, (67 91, (91,9 (6 (91, ( (91 (9

Abstract Background There are few studies related to Coronavirus Disease 2019 (COVID-19) on the prevalence and nature of pain symptoms after hospital discharge, especially in individuals who develop moderate to severe disease forms. Therefore, this study aimed to evaluate the presence of chronic pain in patients discharged after hospitalization for COVID-19, and the relationship between the presence of chronic pain and intensive care stay, demographics, and risk factors for the worst Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outcome. Methods A cross-sectional observational study was carried out on patients with COVID-19 who recovered after hospitalization. Patients were recruited at the least 3 months after discharge and their hospital's health files were prospected. The variables evaluated were demographics, the severity of SARS-CoV-2 infection (considering the need for intensive care), and the presence of chronic pain. The results were shown in a descriptive manner, and multivariate analysis expressed as Odds Ratios (ORs) and respective Confidence Intervals (CIs) for the outcomes studied. Statistical significance was set at p < 0.05. Results Of 242 individuals included, 77 (31.8%) reported chronic pain related to COVID-19, with no correlation with the severity of infection. Female sex and obesity were associated with a higher risk for chronic pain with ORs of 2.69 (Confidence Interval [95% CI 1.4 to 5.0]) and 3.02 (95% CI 1.5 to 5.9). The limbs were the most affected areas of the body. Conclusion Chronic pain is common among COVID-19 survivors treated in hospital environments. Female sex and obesity are risk factors for its occurrence. 201 COVID19 COVID 19 (COVID-19 forms Therefore COVID19, 19, stay demographics SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 outcome crosssectional cross sectional COVID-1 hospitals s prospected SARS-CoV- considering care, , care) manner (ORs CIs (CIs studied 005 0 05 0.05 24 included 7 31.8% 318 31 8 (31.8% 269 69 2.6 95% 95 [95 14 1 4 1. 5.0 50 5 5.0] 302 02 3.0 (95 15 5.9. 59 5.9 . 9 5.9) body environments occurrence 20 COVID1 (COVID-1 (SARS-CoV- COVID- SARS-CoV 00 0.0 31.8 (31.8 26 6 2. [9 5. 30 3. (9 (COVID- (SARS-CoV 0. 31. (31. [ ( (COVID (31 (3

Abstract The objective of this study was to evaluate the productive performance, egg quality and the morphometry of the organs of Japanese quails (Cotournix cotournix japônica) when kept in comfort and under thermal stress. 192 nine-week-old quail were used, distributed in a completely randomized design at two temperatures (T1 = 24 °C and T2 = 32 °C), with 12 replicates of eight birds each, with an experimental period of 63 days, divided into three 21-day periods. Feed intake (g fowl-1 day-1), water consumption (mL fowl-1 day-1), egg production (%), egg weight (g), egg mass (g fowl- 1 day-1) and feed conversion (kg kg-1 and kg dozen-1). Laying quails after their production cycle are marketed as beef animals. It is observed that the average final live weight was reduced (P = 0.0362) by 27.58 g in birds kept at a temperature of 32 oC, which can compromise its commercial value. The feed intake of the birds was reduced (P = 0.0051) by 14.75% with an increase in ambient temperature. Birds kept at a temperature of 32 oC for 12 h daily showed a reduction in feed intake, final weight, yolk, and gizzard weight, but without affecting egg production, weight and mass. performance Cotournix japônica stress 19 nineweekold nine week old used T1 T (T 2 C 3 °C, , °C) each 6 days 21day day 21 periods fowl1 fowl day1, day1 mL %, % (%) g, (g) day-1 kg1 kg- dozen1. dozen1 dozen . dozen-1) animals P 0.0362 00362 0 0362 2758 27 58 27.5 value 0.0051 00051 0051 1475 14 75 14.75 yolk (% day- dozen-1 0.036 0036 036 275 5 27. 0.005 0005 005 147 7 14.7 ( dozen- 0.03 003 03 0.00 000 00 14. 0.0 0.

ABSTRACT Objectives: To analyze and compare intrinsic and extrinsic factors that cause falls among women receiving treatment for osteoporosis. Subjects and methods: A cross-sectional study of women ≥50 years receiving treatment for osteoporosis. Participants filled out questionnaires (demographic characteristics), and researchers took anthropometric measurements of bone mineral density, handgrip strength (HGS), ankle range of motion (ROM), and gait speed (GS). We also evaluated the Timed Up and Go Test (TUGT), Five Times Sit-to-Stand Test (SST), and Falls Efficacy Scale–International (FES-I) and investigated the extrinsic factors for falls. Results: We included 144 participants (71.6 [8.3 years]), who reported 133 falls. We classified participants into a non-faller group (NFG; 0 falls, n = 71, 49.5%), a faller group (FG; 1 fall, n = 42, 28.9%), and a recurrent-faller group (RFG; more than 1 fall, n = 31, 21.5%). Most patients had an increased risk of falling according to the TUGT, SST, reduced ankle ROM, and GS (P < .005 for all). FES-I was associated with sporadic and recurrent falls. For the multivariate analysis, the number of falls was influenced by the presence of ramps (RR 0.48, 95% CI, 0.26-0.87, P = .015), uneven surfaces (RR 1.6, 95% CI. 1.05-2.43, P = .028), and antislippery adhesive on stairs (RR 2.75, 95% CI, 1.77-4.28, P < .001). Conclusion: Patients receiving treatment for osteoporosis are influenced by intrinsic and extrinsic factors that cause falls. Lower-limb strength and power-discriminated participants at a higher risk of falls, but extrinsic factors varied. Only uneven floors and antislippery adhesives on stairs were associated with increased frequency of falls. Objectives methods crosssectional cross sectional 50 ≥5 demographic characteristics, characteristics , characteristics) density HGS, HGS (HGS) ROM (ROM) GS. . (GS) TUGT (TUGT) SittoStand Sit Stand SST (SST) ScaleInternational Scale International FESI FES I (FES-I Results 14 71.6 716 71 6 (71. 8.3 83 8 3 [8. years, years]) 13 nonfaller non NFG (NFG 49.5%, 495 49.5% 49 5 49.5%) FG (FG fall 42 28.9%, 289 28.9% 28 9 28.9%) recurrentfaller RFG (RFG 31 21.5%. 215 21.5% 21 21.5%) 005 .00 all. all all) analysis RR 048 48 0.48 95 CI 0.260.87, 026087 0.26 0.87, 26 87 0.26-0.87 .015, 015 .015 .015) 16 1.6 1.052.43, 105243 1.05 2.43, 05 2 43 1.05-2.43 .028, 028 .028 .028) 275 75 2.75 1.774.28, 177428 1.77 4.28, 77 4 1.77-4.28 .001. 001 .001 .001) Conclusion Lowerlimb Lower limb powerdiscriminated power discriminated varied ≥ (HGS (ROM (GS (TUGT (SST 71. 7 (71 8. [8 years] 49.5 28.9 21.5 00 .0 04 0.4 260 0.260.87 02608 026 0.2 087 0.87 0.26-0.8 01 .01 1. 052 1.052.43 10524 105 1.0 243 2.43 1.05-2.4 02 .02 27 2.7 774 1.774.28 17742 177 1.7 428 4.28 1.77-4.2 (7 [ 49. 28. 21. 0. 0.260.8 0260 08 0.8 0.26-0. 1.052.4 1052 10 24 2.4 1.05-2. 2. 1.774.2 1774 17 4.2 1.77-4. ( 0.260. 0.26-0 1.052. 1.05-2 1.774. 4. 1.77-4 0.260 0.26- 1.052 1.05- 1.774 1.77-

Objective: To estimate the mortality trend and analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study of deaths from leukemias and lymphomas obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, and estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. APVP rates were collected from the Cancer Mortality Altas. Results: In Brazil, the mortality rate trend showed stability for both diseases, leukemias (APC=0.2; 95%CI-0.0;0.3) and lymphomas (APC=0.2; 95%CI-0.4;0.1). In the state, the rate for leukemias also showed stability (APC=0.3; 95%CI-1.0;1.6). For lymphomas, the trend was upward (APC=2.3; 95%CI0.5;4.2), however, decreasing trend was observed among those younger than 59 years. For leukemias, the APVP rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, these rates were 27 and 22/100,000, respectively, with the highest rates found in males. Conclusion: The mortality rates from leukemia and lymphoma in Mato Grosso show a behavior different from that observed nationally, with an increasing trend for lymphomas and no differences between age groups for both diseases. The APVP rates for leukemias were similar, however, for lymphomas, it was higher among men and lower for the state when compared to Brazil.

Objetivo: Estimar a tendência de mortalidade e analisar os anos potenciais de vida perdidos (APVP) por leucemias e linfomas no Brasil e Mato Grosso, entre os anos de 2001 a 2019. Métodos: Estudo de série temporal de óbitos por leucemias e linfomas obtidos do Sistema de Informações sobre Mortalidade. As tendências foram calculadas por faixa etária pelo método de regressão Joinpoint, usando ano calendário como variável regressora, e estimadas a variação percentual anual (APC) e variação percentual média anual, considerando intervalos de confiança de 95%. As taxas de APVP foram coletadas do Altas de Mortalidade por câncer. Resultados: No Brasil, a tendência da taxa de mortalidade apresentou estabilidade para ambos os agravos, leucemias (APC=0,2; IC95%-0,0;0,3) e linfomas (APC=0,2; IC95%-0,4;0,1). No estado, a taxa por leucemias também apresentou estabilidade (APC=0,3; IC95%-1,0;1,6). Para os linfomas, a tendência foi de aumento (APC=2,3; IC95%0,5;4,2), contudo, tendência decrescente foi observada entre aqueles com menos de 59 anos. Para leucemias, as taxas de APVP foram de 64 e 65/100.000 no Brasil e no Mato Grosso, respectivamente. Para linfomas, esses valores foram de 27 e 22/100.000, respectivamente, sendo as maiores taxas encontradas no sexo masculino. Conclusão: As taxas de mortalidade por leucemias e linfomas no Mato Grosso apresentam comportamento diferente do observado nacionalmente, com tendência crescente para linfomas e sem diferenças entre as faixas etárias, para ambos os agravos. As taxas de APVP por leucemias foram semelhantes, no entanto, para os linfomas, foi maior entre os homens e menores para o estado, quando comparadas as do Brasil.

ABSTRACT Background: Inflammatory bowel disease (IBD) is an immune-mediated disorder that includes Crohn’s disease (CD) and ulcerative colitis. CD is characterized by a transmural intestinal involvement from the mouth to the anus with recurrent and remitting symptoms that can lead to progressive bowel damage and disability over time. Objective: To guide the safest and effective medical treatments of adults with CD. Methods: This consensus was developed by stakeholders representing Brazilian gastroenterologists and colorectal surgeons (Brazilian Organization for Crohn's disease and Colitis (GEDIIB)). A systematic review of the most recent evidence was conducted to support the recommendations/statements. All included recommendations and statements were endorsed in a modified Delphi panel by the stakeholders and experts in IBD with an agreement of at least 80% or greater consensus rate. Results and conclusion: The medical recommendations (pharmacological and non-pharmacological interventions) were mapped according to the stage of treatment and severity of the disease in three domains: management and treatment (drug and surgical interventions), criteria for evaluating the effectiveness of medical treatment, and follow-up/patient monitoring after initial treatment. The consensus is targeted towards general practitioners, gastroenterologists, and surgeons interested in treating and managing adults with CD and supports the decision-making of health insurance companies, regulatory agencies, and health institutional leaders or administrators. Background (IBD immunemediated immune mediated Crohns Crohn s (CD colitis time Objective Methods GEDIIB. GEDIIB . (GEDIIB)) recommendationsstatements recommendations/statements 80 rate conclusion pharmacological nonpharmacological non interventions domains drug interventions, , followup/patient followuppatient follow up/patient up patient practitioners decisionmaking decision making companies agencies administrators (GEDIIB) 8 followup uppatient (GEDIIB

RESUMO Contexto: A doença inflamatória intestinal (DII) é uma doença imunomediada que inclui a doença de Crohn (DC) e a retocolite ulcerativa. A DC é caracterizada por um envolvimento intestinal transmural da boca ao ânus com sintomas recorrentes e remitentes que podem levar a danos intestinais progressivos e incapacidade ao longo do tempo. Objetivo: Orientar os tratamentos médicos mais seguros e eficazes de adultos com DC. Métodos: Este consenso foi desenvolvido por autores que representam gastroenterologistas e cirurgiões brasileiros especialistas em doenças colorretais (GEDIIB, Organização Brasileira de Doença de Crohn e Colite). Uma revisão sistemática das evidências mais recentes foi realizada para apoiar as recomendações/declarações. Todas as recomendações e declarações incluídas foram endossadas em um painel Delphi modificado pelas partes interessadas e especialistas em DII com uma concordância de pelo menos 80% ou mais. Resultados e conclusão: As recomendações médicas (intervenções farmacológicas e não farmacológicas) foram mapeadas de acordo com o estágio de tratamento e gravidade da doença em três domínios: manejo e tratamento (intervenções medicamentosas e cirúrgicas), critérios para avaliar a eficácia do tratamento médico, e acompanhamento/monitoramento do paciente após o tratamento inicial. O consenso é direcionado a clínicos gerais, gastroenterologistas e cirurgiões interessados em tratar e gerenciar adultos com DC e apoia a tomada de decisões de companhias de seguro de saúde, agências reguladoras e líderes ou administradores de instituições de saúde. Contexto (DII (DC ulcerativa tempo Objetivo Métodos GEDIIB, GEDIIB (GEDIIB Colite. Colite . Colite) recomendaçõesdeclarações recomendações/declarações 80 conclusão intervenções domínios cirúrgicas, cirúrgicas , cirúrgicas) médico acompanhamentomonitoramento acompanhamento monitoramento inicial gerais saúde 8

ABSTRACT Background: Inflammatory bowel diseases are immune-mediated disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). UC is a progressive disease that affects the colorectal mucosa causing debilitating symptoms leading to high morbidity and work disability. As a consequence of chronic colonic inflammation, UC is also associated with an increased risk of colorectal cancer. Objective: This consensus aims to provide guidance on the most effective medical management of adult patients with UC. Methods: A consensus statement was developed by stakeholders representing Brazilian gastroenterologists and colorectal surgeons (Brazilian Organization for Crohn’s Disease and Colitis [GEDIIB]). A systematic review including the most recent evidence was conducted to support the recommendations and statements. All recommendations/statements were endorsed using a modified Delphi Panel by the stakeholders/experts in inflammatory bowel disease with at least 80% or greater consensus. Results and conclusion: The medical recommendations (pharmacological and non-pharmacological) were mapped according to the stage of treatment and severity of the disease onto three domains: management and treatment (drug and surgical interventions), criteria for evaluating the effectiveness of medical treatment, and follow-up/patient monitoring after initial treatment. The consensus targeted general practitioners, gastroenterologists and surgeons who manage patients with UC, and supports decision-making processes by health insurance companies, regulatory agencies, health institutional leaders, and administrators. Background immunemediated immune mediated Crohns Crohn s CD (CD . (UC) disability inflammation cancer Objective Methods GEDIIB. GEDIIB [GEDIIB]) statements recommendationsstatements stakeholdersexperts experts 80 conclusion pharmacological nonpharmacological non non-pharmacological domains drug interventions, interventions , interventions) followup/patient followuppatient follow up/patient up patient practitioners decisionmaking decision making companies agencies leaders administrators (UC [GEDIIB] 8 followup uppatient [GEDIIB

RESUMO Contexto: As doenças inflamatórias intestinais são doenças imunomediadas que incluem a doença de Crohn (DC) e a retocolite ulcerativa (RCU). A RCU é uma doença progressiva que acomete a mucosa colorretal causando sintomas debilitantes levando a alta morbidade e incapacidade laboral. Como consequência da inflamação crônica do cólon, a RCU também está associada a um risco aumentado de câncer colorretal. Objetivo: Este consenso visa fornecer orientações sobre o manejo médico mais eficaz de pacientes adultos com RCU. Métodos: As recomendações do consenso foram desenvolvidas por gastroenterologistas e cirurgiões colorretais referências no Brasil (membros da Organização Brasileira para Doença de Crohn e Colite [GEDIIB]). Uma revisão sistemática, incluindo as evidências mais recentes, foi conduzida para apoiar as recomendações. Todas as recomendações foram endossadas pelas partes interessadas/especialistas em doença inflamatória intestinal usando um Painel Delphi modificado. O nível de concordância para alcançar consenso foi de 80% ou mais. Resultados e conclus ão: As recomendações médicas (farmacológicas e não farmacológicas) foram mapeadas de acordo com o estágio de tratamento e gravidade da doença em três domínios: manejo e tratamento (intervenções medicamentosas e cirúrgicas), critérios para avaliar a eficácia do tratamento médico, e acompanhamento/monitoramento do paciente após o tratamento inicial. O consenso foi direcionado a clínicos gerais, gastroenterologistas e cirurgiões que tratam pacientes com RCU e apoia os processos de tomada de decisão por companhias de seguro de saúde, agências reguladoras, líderes institucionais de saúde e administradores. Contexto DC (DC . (RCU) laboral cólon Objetivo Métodos membros GEDIIB. GEDIIB [GEDIIB]) sistemática recentes interessadasespecialistas interessadas especialistas modificado 80 ão farmacológicas domínios intervenções cirúrgicas, cirúrgicas , cirúrgicas) acompanhamentomonitoramento acompanhamento monitoramento inicial gerais reguladoras administradores (RCU [GEDIIB] 8 [GEDIIB

RESUMO: Objetivos: Estimar a tendência de mortalidade e analisar os anos potenciais de vida perdidos (APVP) por leucemias e linfomas no Brasil e em Mato Grosso, entre os anos de 2001 e 2019. Métodos: Estudo de série temporal de óbitos por leucemias e linfomas obtidos do Sistema de Informação sobre Mortalidade. As tendências foram calculadas por faixa etária pelo método de regressão joinpoint, usando ano calendário como variável regressora, e estimaram-se a variação percentual anual (APC) e a variação percentual média anual, considerando intervalos de confiança de 95% (IC95%). As taxas de APVP foram coletadas do Atlas de Mortalidade por Câncer. Resultados: No Brasil, a tendência da taxa de mortalidade apresentou estabilidade para ambos os agravos, leucemias (APC=0,2; IC95% 0,0–0,3) e linfomas (APC=0,2; IC95% 0,4–0,1). No estado, a taxa por leucemias também apontou estabilidade (APC=0,3; IC95% 1,0–1,6). Para os linfomas, a tendência foi de aumento (APC=2,3; IC95% 0,5–4,2), contudo tendência decrescente foi observada entre aqueles com menos de 59 anos. Para leucemias, as taxas de APVP foram de 64 e 65/100 mil no Brasil e em Mato Grosso, respectivamente. Para linfomas, esses valores foram de 27 e 22/100 mil, respectivamente, sendo as maiores taxas encontradas no sexo masculino. Conclusão: As taxas de mortalidade por leucemias e linfomas em Mato Grosso apresentam comportamento diferente do observado nacionalmente, com tendência crescente para linfomas e sem diferenças entre as faixas etárias, para ambos os agravos. As taxas de APVP por leucemias foram semelhantes, no entanto para os linfomas foram maiores entre os homens e menores para o estado, quando comparadas com as do Brasil. RESUMO Objetivos (APVP 200 2019 Métodos joinpoint regressora estimaramse estimaram se APC (APC 95 IC95%. IC95 IC . (IC95%) Câncer Resultados agravos APC=0,2 APC02 0 2 (APC=0,2 0,0–0,3 0003 3 0,4–0,1. 0401 0,4–0,1 4 1 0,4–0,1) estado APC=0,3 APC03 (APC=0,3 1,0–1,6. 1016 1,0–1,6 6 1,0–1,6) APC=2,3 APC23 (APC=2,3 0,5–4,2, 0542 0,5–4,2 , 5 0,5–4,2) 65100 65 100 65/10 respectivamente 22100 22 22/10 masculino Conclusão nacionalmente etárias semelhantes 20 201 9 IC9 (IC95% APC=0, APC0 (APC=0, 0,0–0, 000 040 0,4–0, 101 1,0–1, APC=2, APC2 (APC=2, 054 0,5–4, 6510 10 65/1 2210 22/1 (IC95 APC=0 (APC=0 0,0–0 00 04 0,4–0 1,0–1 APC=2 (APC=2 05 0,5–4 651 65/ 221 22/ (IC9 APC= (APC= 0,0– 0,4– 1,0– 0,5– (IC 0,0 0,4 1,0 0,5 0, 1,

ABSTRACT: Objective: To estimate the mortality trend and to analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study on deaths from leukemias and lymphomas with data obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. PYLL rates were collected from the Cancer Mortality Atlas. Results: In Brazil, the mortality rate trend remained stable for both diseases in the period: leukemias (APC=0.2; 95%CI 0.0–0.3) and lymphomas (APC=0.2; 95%CI 0.4–0.1). In Mato Grosso state, the rate for leukemias was also stable (APC=0.3; 95%CI 1.0–1.6). For lymphomas, the trend was ascendant (APC=2.3; 95%CI 0.5–4.2), but descending among people younger than 59 years. For leukemias, PYLL rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, 27 and 22/100,000, respectively, with the highest rates found among males. Conclusion: The behavior of mortality rates from leukemia and lymphoma in Mato Grosso was different from that observed nationally, with an upward trend for lymphomas and no differences between age groups for both diseases. PYLL rates for leukemias were similar, while for lymphomas they were higher among men and lower in Mato Grosso when compared to Brazil. ABSTRACT Objective (PYLL 200 2019 Methods Timeseries Time series System method variable APC (APC 95 intervals Atlas Results period APC=0.2 APC02 0 2 (APC=0.2 95CI CI 0.0–0.3 0003 3 0.4–0.1. 0401 0.4–0.1 . 4 1 0.4–0.1) state APC=0.3 APC03 (APC=0.3 1.0–1.6. 1016 1.0–1.6 6 1.0–1.6) APC=2.3 APC23 (APC=2.3 0.5–4.2, 0542 0.5–4.2 , 5 0.5–4.2) 65100000 65 100 000 65/100,00 respectively 22100000 22 22/100,000 males Conclusion nationally similar 20 201 9 APC=0. APC0 (APC=0. 0.0–0. 040 0.4–0. 101 1.0–1. APC=2. APC2 (APC=2. 054 0.5–4. 6510000 10 00 65/100,0 2210000 22/100,00 APC=0 (APC=0 0.0–0 04 0.4–0 1.0–1 APC=2 (APC=2 05 0.5–4 651000 65/100, 221000 22/100,0 APC= (APC= 0.0– 0.4– 1.0– 0.5– 65100 65/100 22100 22/100, 0.0 0.4 1.0 0.5 6510 65/10 2210 22/100 0. 1. 651 65/1 221 22/10 65/ 22/1 22/

RESUMO: Objetivos: Estimar a tendência de mortalidade e analisar os anos potenciais de vida perdidos (APVP) por leucemias e linfomas no Brasil e em Mato Grosso, entre os anos de 2001 e 2019. Métodos: Estudo de série temporal de óbitos por leucemias e linfomas obtidos do Sistema de Informação sobre Mortalidade. As tendências foram calculadas por faixa etária pelo método de regressão joinpoint, usando ano calendário como variável regressora, e estimaram-se a variação percentual anual (APC) e a variação percentual média anual, considerando intervalos de confiança de 95% (IC95%). As taxas de APVP foram coletadas do Atlas de Mortalidade por Câncer. Resultados: No Brasil, a tendência da taxa de mortalidade apresentou estabilidade para ambos os agravos, leucemias (APC=0,2; IC95% 0,0–0,3) e linfomas (APC=0,2; IC95% 0,4–0,1). No estado, a taxa por leucemias também apontou estabilidade (APC=0,3; IC95% 1,0–1,6). Para os linfomas, a tendência foi de aumento (APC=2,3; IC95% 0,5–4,2), contudo tendência decrescente foi observada entre aqueles com menos de 59 anos. Para leucemias, as taxas de APVP foram de 64 e 65/100 mil no Brasil e em Mato Grosso, respectivamente. Para linfomas, esses valores foram de 27 e 22/100 mil, respectivamente, sendo as maiores taxas encontradas no sexo masculino. Conclusão: As taxas de mortalidade por leucemias e linfomas em Mato Grosso apresentam comportamento diferente do observado nacionalmente, com tendência crescente para linfomas e sem diferenças entre as faixas etárias, para ambos os agravos. As taxas de APVP por leucemias foram semelhantes, no entanto para os linfomas foram maiores entre os homens e menores para o estado, quando comparadas com as do Brasil.

ABSTRACT: Objective: To estimate the mortality trend and to analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study on deaths from leukemias and lymphomas with data obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. PYLL rates were collected from the Cancer Mortality Atlas. Results: In Brazil, the mortality rate trend remained stable for both diseases in the period: leukemias (APC=0.2; 95%CI 0.0–0.3) and lymphomas (APC=0.2; 95%CI 0.4–0.1). In Mato Grosso state, the rate for leukemias was also stable (APC=0.3; 95%CI 1.0–1.6). For lymphomas, the trend was ascendant (APC=2.3; 95%CI 0.5–4.2), but descending among people younger than 59 years. For leukemias, PYLL rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, 27 and 22/100,000, respectively, with the highest rates found among males. Conclusion: The behavior of mortality rates from leukemia and lymphoma in Mato Grosso was different from that observed nationally, with an upward trend for lymphomas and no differences between age groups for both diseases. PYLL rates for leukemias were similar, while for lymphomas they were higher among men and lower in Mato Grosso when compared to Brazil.

SUMMARY OBJECTIVE: This study aims to know the main determinants of hesitation to the vaccine against COVID-19 mentioned by medical students in Brazil. METHODS: A cross-sectional study with 250 students who answered the online questionnaire between December 18, 2020 and January 8, 2021. RESULTS: Most students (84%) mentioned the intention to take anti-COVID vaccine and 14% were hesitant. Information provided by governments (59.2%), the pharmaceutical industry (54.4%), and the press (51.6%) were the items that most generated vaccine hesitation. CONCLUSION: In the context of the COVID-19, vaccine hesitation is an additional concern because adherence to vaccination is a recurring challenge. The category of contextual influences predominated among the main determinants of anti-COVID vaccine hesitation expressed by medical students in Brazil, disfavoring vaccine adherence in this public.

Abstract Magnetic nanopowders were developed by functionalization of bimagnetic core@shell nanoparticles with cysteine (CoFe2O4@ɣ-Fe2O3@Cys), which present a core with high saturation magnetization (CoFe2O4) combined with a shell with high long-term chemical stability (ɣ-Fe2O3) and a sorptive L-cysteine layer. Samples of two different mean sizes were elaborated and characterized by XRD, TEM, FTIR, SER, zetametry and SQUID magnetometry. The adsorption of Pb(II) by the magnetic nanopowders was investigated as a function of pH, time, and pollutant concentration. The Langmuir model fitted well the adsorption data indicating monolayer adsorption, and a maximum adsorption capacity of 1.2 mg/g was found for pH 5. The kinetic data were well correlated to the pseudo-second-order model and the best equilibrium time was 120 min. The adsorption mechanism mainly involves electrostatic interactions in pH 5-7 and hard–soft-acid–base interactions in low pH. Moreover, the nanoparticles were recovered and reused in readsorption experiments keeping a good removal efficiency.

ABSTRACT Chagas disease (CD) has been considered endemic in the South of Rio Grande do Sul (RS) State, Brazil. This study aimed at evaluating the occurrence of Trypanosoma cruzi vectors based on the main species captured in Southern Rio Grande do Sul State from 2008 to 2019. The study area comprised counties that belong to the 3rd Regional Health Coordination (RHC) and to the 7th RHC, whose headquarters are in Pelotas and Bage, respectively. The study was based on secondary data provided by the partnership between the Federal University of Pelotas, Rio Grande do Sul State (UFPel-RS) and the State Health Surveillance Center in RS (SCHS-RS). One thousand and four hundred triatomines were captured in the area supervised by the 3rd RHC, mainly in Cangucu (37.7%), Piratini (22.4%) and Pinheiro Machado (15.1%), while, in the area supervised by the 7th RHC, the largest number of triatomines was captured in Lavras do Sul (64.15%). In both areas, Triatoma rubrovaria (90.6%) and Panstrongylus tupynambai (7.4%) were the most common species. Most were captured inside households but T. cruzi-positive insects were not found in the period under study. The results of this study show that, in Southern Rio Grande do Sul State, there is still a high rate of triatomine household invasion and dispersal, mainly by T. rubrovaria. Thus, the entomological surveillance should be maintained with the participation of the population and further studies should be deepened in the area.