Resumo Fundamento Ainda não temos informações acerca do impacto da pandemia da COVID-19 sobre a atividade médica assistencial no Brasil. Objetivo Descrever as repercussões da pandemia da COVID-19 na rotina de atendimentos em um hospital terciário, referência regional em cardiologia e oncologia. Métodos Estudo de corte transversal. Foi realizado levantamento dos atendimentos no período de 23/03/2020 (fechamento do comércio local) até 23/04/2020 (P20) e comparado com o mesmo período em 2019 (P19).Resultados: Detectamos redução no número de consultas cardiológicas, teste ergométrico, Holter, monitorização ambulatorial da pressão arterial, eletrocardiograma e ecocardiograma (90%, 84%, 94%, 92%, 94% e 81%, respectivamente). Em relação à cirurgia cardíaca e cateterismo cardíaco, houve redução de 48% e 60%, respectivamente. Aumento no número de angioplastia transluminal coronária (33%) e de implante de marca-passo definitivo (29%). Houve 97 internamentos na UTI em P19, contra 78 em P20, redução de 20%. Diminuição dos atendimentos no pronto-socorro cardiológico (45%) e nos internamentos na enfermaria de cardiologia (36%). Houve diminuição nas consultas oncológicas de 30%. Sessões de quimioterapia reduziram de 1.944 para 1.066 (45%). Sessões de radioterapia diminuíram 19%. Conclusão A COVID-19 provocou redução considerável no número de consultas nos ambulatórios de cardiologia, oncologia e demais especialidades. Houve uma preocupante diminuição no número de cirurgias cardíacas e nas sessões de quimioterapia e radioterapia nas semanas iniciais da pandemia. A procura por atendimento no pronto-socorro cardiológico, assim como as internações na UTI e enfermaria cardiológicas, também reduziram, gerando preocupação acerca da evolução e prognóstico destes pacientes portadores de outras patologias, que não a COVID-19, nestes tempos de pandemia. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)

Abstract Background We still do not have information regarding the impact of the COVID-19 pandemic on medical care activity in Brazil. Objective To describe the repercussions of the COVID-19 pandemic on the care routine of a tertiary hospital, which is a regional reference in cardiology and oncology. Methods Cross-sectional cohort study. We conducted a survey of medical visits from March 23, 2020 (when local commerce was closed) to April 23, 2020 (P20), in comparison with the same period in 2019 (P19). Results We found decreases in the number of cardiology consultations, exercise tests, Holter, ambulatory blood pressure monitoring, electrocardiogram, and echocardiogram (90%, 84%, 94%, 92%, 94%, and 81%, respectively). In relation to cardiac surgery and cardiac catheterization, there were 48% and 60% decreases, respectively. There was an increase in the number of percutaneous transluminal coronary angioplasties (33%) and definitive pacemaker implantations (29%). There were 97 admissions to the ICU during P19, in contrast with 78 during P20, a 20% decrease. Visits to the cardiac emergency room (45%) and admissions to the cardiology ward (36%) also decreased. The decrease in oncology consultations was 30%. Chemotherapy sessions decreased from 1,944 to 1,066 (45%), and radiotherapy sessions decreased by 19%. Conclusion COVID-19 has led to a considerable decrease in the number of consultations in outpatient clinics for cardiology, oncology, and other specialties. There was a concerning decrease in the number of cardiac surgeries, chemotherapy sessions, and radiotherapy sessions during the initial weeks of the pandemic. The number of people seeking care in the cardiac emergency room and the number of admissions to the cardiology ward and ICU also decreased, generating concern regarding the evolution and prognosis of these patients with pathologies other than COVID-19 during this pandemic time. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0)

Resumo Fundamento: O D-limoneno (DL) é um monoterpeno e o principal componente do óleo essencial de frutas cítricas. Ele apresenta atividades anti-hiperglicêmicas e vasodilatadoras. Objetivos: Este estudo avaliou os efeitos cardiovasculares e antiarrítmicos potenciais do DL em ratos. Métodos: Os parâmetros hemodinâmicos e eletrocardiográficos (ECG) foram mensurados em ratos Wistar machos que, sob anestesia, tiveram a aorta abdominal e a veia cava inferior canuladas e receberam eletrodos implantados subcutaneamente. Na abordagem in vitro, o coração foi removido e perfundido utilizando a técnica de Langendorff. O nível de significância adotado foi de 5% (p < 0,05). Resultados: DL, nas doses de 10, 20 e 40 mg/kg (i.v), produziu bradicardia intensa e persistente associada à hipotensão. A bradicardia com QTc prolongado foi observada no registro in vivo do ECG. No modelo in vivo de arritmia induzida por Bay K8644, DL (10 mg / kg) houve diminuição do escore da arritmia de 15,33 ± 3,52 para 4,0 ± 2,64 u.a (p < 0,05, n = 4). Em corações perfundidos isolados, o DL (10-3 M) promoveu reduções significativas na frequência cardíaca (de 228,6 ± 8,5 ms para 196,0 ± 9,3 bpm; p < 0,05) e na pressão desenvolvida do ventrículo esquerdo (de 25,2 ± 3,4 para 5,9 ± 1,8 mmHg; n = 5, p < 0,05). Conclusões: O DL produz bradicardia e atividade antiarrítmica no coração de ratos.

Abstract Background: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. Objectives: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. Methods: Hemodynamic and electrocardiographic (ECG) parameters were measured in male Wistar rats, which under anesthesia had been cannulated in the abdominal aorta and lower vena cava and had electrodes subcutaneously implanted. In the in vitro approach, the heart was removed and perfused using the Langendorff technique. The significance level adopted was 5% (p < 0.05). Results: DL, in doses of 10, 20, and 40 mg/kg (i.v), produced intense and persistent bradycardia associated with hypotension. Bradycardia with prolonged QTc was observed in the ECG in vivo recording. In the in vivo model of arrhythmia induced by Bay K8644, DL (10 mg/kg) decreased the arrhythmia score from 15.33 ± 3.52 to 4.0 ± 2.64 u.a (p < 0.05, n = 4). In isolated perfused hearts, DL (10-3 M) promoted significant reductions in heart rate (from 228.6 ± 8.5 ms to 196.0 ± 9.3 bpm; p < 0.05) and left ventricular development pressure (from 25.2 ± 3.4 to 5.9 ± 1.8 mmHg; n = 5, p < 0.05). Conclusions: DL produces bradycardia and antiarrhythmic activity in rat heart.

RESUMO Objetivo: Descrever a frequência de tabagismo ativo entre pacientes com asma e indivíduos sem asma, usando questionários padronizados e dosagem da cotinina urinária. Métodos: Estudo transversal realizado em Salvador (BA), com 1.341 indivíduos, sendo 498 com asma grave, 417 com asma leve/moderada e 426 sem asma. O tabagismo foi identificado por meio de autorrelato utilizando questionários e por mensuração da cotinina urinária. Para a comparação das variáveis estudadas, utilizaram-se os testes do qui-quadrado e de Kruskal-Wallis. Resultados: Dos 55 participantes (4,1%) que se declararam tabagistas atuais, 5, 17 e 33 eram dos grupos asma grave, asma leve/moderada e sem asma, respectivamente. Desses 55, 32 (58,2%) eram tabagistas diários e 23 (41,8%) eram tabagistas ocasionais. Observaram-se níveis elevados de cotinina urinária entre não fumantes autodeclarados e tabagistas pregressos, especialmente no grupo asma grave, o que sugere omissão do hábito atual de fumar. A carga tabágica entre os fumantes e a proporção de ex-tabagistas foram maiores no grupo asma grave do que no grupo asma leve/moderada. Conclusões: O tabagismo pregresso esteve associado à asma grave. Tabagismo atual também foi observado em alguns pacientes com asma grave e detectou-se omissão em alguns casos. A investigação de tabagismo deve ser meticulosa em pacientes com asma grave e a entrevista desses deve ser complementada por uma avaliação objetiva.

ABSTRACT Objective: To determine the frequency of active smoking among patients with asthma and individuals without asthma by self-report and urinary cotinine measurement. Methods: This was a cross-sectional study conducted in the city of Salvador, Brazil, and involving 1,341 individuals: 498 patients with severe asthma, 417 patients with mild-to-moderate asthma, and 426 individuals without asthma. Smoking status was determined by self-report (with the use of standardized questionnaires) and urinary cotinine measurement. The study variables were compared with the chi-square test and the Kruskal-Wallis test. Results: Of the sample as a whole, 55 (4.1%) reported being current smokers. Of those, 5 had severe asthma, 17 had mild-to-moderate asthma, and 33 had no asthma diagnosis. Of the 55 smokers, 32 (58.2%) were daily smokers and 23 (41.8%) were occasional smokers. Urinary cotinine levels were found to be high in self-reported nonsmokers and former smokers, especially among severe asthma patients, a finding that suggests patient nondisclosure of smoking status. Among smokers, a longer smoking history was found in patients with severe asthma when compared with those with mild-to-moderate asthma. In addition, the proportion of former smokers was higher among patients with severe asthma than among those with mild-to-moderate asthma. Conclusions: Former smoking is associated with severe asthma. Current smoking is observed in patients with severe asthma, and patient nondisclosure of smoking status occurs in some cases. Patients with severe asthma should be thoroughly screened for smoking, and findings should be complemented by objective testing.

RESUMO Objetivos Este trabalho estimou a prevalência conjunta de horas insuficientes de sono/dia e excesso de adiposidade corporal em escolares, bem como verificou as características sociodemográficas e comportamentais correlatas. Métodos Trata-se de estudo transversal de base escolar, realizado com 975 participantes de 11 a 14 anos de idade, em Florianópolis (SC). A adiposidade corporal foi avaliada por mensuração das dobras cutâneas tricipital e subescapular, sendo classificada segundo Lohman. O total de horas de sono/dia foi relatado pelos pais/respon-sáveis dos escolares, e posteriormente classificado em <8 horas por dia e ≥8 horas por dia. Os dados de condições sociodemográficas, consumo alimentar e atividade física foram levantados por questionário autopreenchível. Utilizou-se o teste Qui-quadrado e a regressão logística multinomial, com nível de significância de 5% para avaliação das associações. Resultados A prevalência conjunta de horas insuficientes de sono/dia e excesso de adiposidade corporal foi de 25,1% (IC95%:20,7-29,9). Os fatores sociodemográficos e comportamentais preditores a essa condição foram faixa etária de 13 a 14 anos e renda mensal no tercil intermediário. Conclusão O estudo concluiu que pouco mais de um quarto dos estudantes apresentou, concomitantemente, horas insuficientes de sono/dia e excesso de adiposidade corporal. Os subgrupos populacionais pertencentes à faixa etária entre 13 e 14 anos e ao tercil intermediário de renda foram mais propícios a apresentar simultaneamente horas insuficientes de sono/dia e excesso de adiposidade corporal.

ABSTRACT Objective This study estimated the combined prevalence of insufficient number of hours of sleep per day and excess body adiposity among young students. The sociodemographic and behavioral characteristics associated with this concurrent health conditions were investigated. Methods This is a cross-sectional school-based study of 975 participants aged 11-14 years in Florianópolis, Santa Catarina state, Brazil. Body adiposity was assessed based on tricipital and subscapular skinfold measurements and classified according to Lohman. The total number of hours of sleep per day was reported by the students’ parents/guardians, and it was classified as follows: as <8 hours per day and ≥8 hours per day. Data on sociodemographic characteristics, food consumption, and physical activity were collected using a self-administered questionnaire. The chi-square test and multinomial logistic regression with a 5% significance level were used to evaluate the association between the variables. Results The combined prevalence of insufficient number of hours of sleep per day and excess body adiposity was 25.1% (CI95%:20.7-29.9). The sociodemographic and behavioral factors predictive of these conditions were as follows: 13-14 year age group and household monthly income in the intermediate tertile. Conclusion The concurrent presence of insufficient sleep and excess body adiposity was found in a little more than a quarter of the students investigated. The population subgroups belonging to the 13-14 year age group and intermediate tertile of income were more likely to have concurrent insufficient number of hours of sleep per day and excess body adiposity.

Abstract Background: With 29 Km2, the Fildes Peninsula is the largest ice free area in King George Island and probably in Antarctica. The region is house of six permanent bases including the only airport in the South Shetlands, which led to impacts on its original landscape and vegetation. In recognition for the need to protect natural values, an Antarctic Specially Protected Area (ASPA 125) was established in the region. Focused mostly on protecting the fossils, the ASPA also plays a role in protecting the vegetation but so far, the management plan for the area does not contain a list of moss species present there. Results: We provided an updated study and checklist of mosses present in ASPA 125. A key to species identification and photographs of main morphological features are also available in this paper. Also, six new occurrences are reported for Fildes Peninsula. Conclusion: Considering the scarce knowledge about specific local floras in Antarctica associated with highly impacted area, of which only a fraction is protected, it is suggested the necessity to invest in detailed sampling studies, as well as in a better understanding of the local floras interactions in Antarctica.

Abstract In this work, four isolates of endophytic fungi (Alternaria alternata, Colletotrichum gloesporioides, Glomerella cingulata and Nigrospora sphaerica), deposited in the culture collection ‘University Recife Mycologia’ (URM) at the Universidade Federal de Pernambuco, were characterized for the genes ITS 1 and 4 (region 5.8 S) and evaluated for taxol production.

Located of the east coast of Fildes Peninsula, South of Ardley Island, at King George Island, Ostrov Geologov (Geologist Islands) is a small island with 0.25 miles long. It only had one plant record published so far. We have conducted extensive fieldwork on the site and provide here a comprehensive checklist and a key for the moss species occurring on the island. Despite its small size, theislandcontains about 35% of all theFildes Peninsula moss flora, six new records were found. The pristine state of the island due to its relative isolation, presence of avian nesting sites and a relatively rich moss flora are strong arguments in favor of protection status for the island.

Ubicada en la costa este de la Península Fildes, al sur de la isla Ardley en Isla 25 de Mayo, la isla del Geólogo es una pequeña isla con 0.5 Km de extensión. Hasta ahora, solo existe un registro de planta. Hemos realizado colecciones y presentamos una lista y una clave para las especies de musgos que ocurren en la isla. Aunque de pequeño tamaño, la isla posee cerca de 35% de todas las especies de musgos que ocurren en la península Fildes y seis nuevos registros fueron encontrados. Su relativo aislamiento de los turistas es un factor que contribuye para su preservación.

Resumo Objetivos: analisar a associação da duração do aleitamento materno exclusivo (AME) e idade de introdução da alimentação complementar (AC) com o excesso de gordura corporal (EGC) em escolares de Florianópolis/SC. Métodos: estudo transversal com amostra probabilística de 1.531 escolares de 7-10 anos de escolas públicas/privadas de Florianópolis/SC. O EGC foi avaliado pela aferição de dobras cutânaeas tricipital e subescapular. Dados sobre AME, AC e variáveis de confusão foram obtidos por entrevista. Regressão de Poisson foi empregada nas análises ajustadas. Resultados: a prevalência de excesso de EGC e AME foi 37,9% (IC95%: 32,4-43,6) e 30,6% (IC95%: 17,3-48,2), respectivamente. O AME por um período menor que 4 meses e maior que 6 meses se manteve associado ao EGC após ajuste pelas variáveis confundidoras. A introdução dos grupos de alimentos na AC não esteve associação ao EGC. Conclusões: a associação do EGC com a AME por menos de quatro meses deve-se possivelmente à oferta precoce de outros tipos de leite como complemento ao materno, enquanto que a associação com AME por mais de seis meses pode ser devido ao fenômeno de aceleração do crescimento.

Abstract Objectives: to analyze the association between exclusive breastfeeding duration (EBF) and the age at which complementary feeding was introduced (CF) with the excess of body fat (BF) in schoolchildren from Florianópolis/SC, southern of Brazil. Methods: cross sectional study, with probability sample of 1,531 schoolchildren aged 7-10 years from Florianópolis/SC. The percentage of BF was defined based on triceps and subscapular skinfolds. Information about EBF, CF and confounders variables were obtained through a questionnaire sent to parents or guardians. Multivariate analyzes were performed using Poisson. Results: the prevalence of BF excess was 37.9% (CI95%: 32.4; 43.6), and 30.6% of children received EBF for 4-6 months (CI95%: 17, 3; 48, 2). The duration of EBF less than 4 or more than 6 months was associated with higher prevalence of BF excess, even after adjustment (p=0.015). Introduction of food groups had no association with BF excess. Conclusions: the association between EBF and the excess of body fat for less than 4 months and higher prevalence of BF excess is probably a consequence of early introduction of others milk types, whilst association between EBF for more than 6 months and higher prevalence of BF excess is because of a catch-up growth situation.

Resumo Fundamento: A alta prevalência de fibrilação atrial (FA) no pós-operatório de cirurgia de revascularização miocárdica ocasiona maior morbidade e mortalidade. Objetivos: Avaliar a eficácia da colchicina como profilaxia para FA no pós-operatório de cirurgia de revascularização miocárdica, o impacto da FA sobre o tempo de internação hospitalar e óbito e identificar fatores de risco para o seu aparecimento. Métodos: Entre maio de 2012 e novembro de 2013, 140 pacientes submetidos à cirurgia de revascularização miocárdica foram randomizados, 69 no grupo controle e 71 no grupo colchicina. A colchicina foi utilizada na dose de 1 mg via oral, duas vezes ao dia, no pré-operatório, e 0,5 mg, duas vezes ao dia, até a alta hospitalar. Dose única de 1 mg foi administrada aos internados 12 horas ou menos antes da cirurgia. Resultados: O desfecho primário foi a taxa de FA no pós-operatório de cirurgia de revascularização miocárdica. Os pacientes do grupo colchicina não apresentaram redução na incidência de FA em comparação aos do grupo controle (7,0% versus 13,0%, respectivamente; p = 0,271). Não houve diferença estatisticamente significativa entre os grupos em relação à taxa de óbito por qualquer causa (5,6% versus 10,1%; p = 0,363) e ao tempo de internação (14,5 ± 11,5 versus 13,3 ± 9,4 dias; p = 0,490). Porém, o grupo colchicina apresentou maior taxa de infecção (26,8% versus 8,7%; p = 0,007). Conclusões: O uso da colchicina para profilaxia da FA no pós-operatório de revascularização miocárdica não se mostrou eficaz neste estudo. Registro Brasileiro de Ensaios Clínicos número RBR-556dhr.

Abstract Background: The high prevalence of atrial fibrillation (AF) in the postoperative period of myocardial revascularization surgery increases morbidity and mortality. Objective: To assess the efficacy of colchicine to prevent AF in the postoperative period of myocardial revascularization surgery, the impact of AF on hospital length of stay and death, and to identify its risk factors. Methods: Between May 2012 and November 2013, 140 patients submitted to myocardial revascularization surgery were randomized, 69 to the control group and 71 to the colchicine group. Colchicine was used at the dose of 1 mg orally, twice daily, preoperatively, and of 0.5 mg, twice daily, until hospital discharge. A single dose of 1 mg was administered to those admitted 12 hours or less before surgery. Results: The primary endpoint was AF rate in the postoperative period of myocardial revascularization surgery. Colchicine group patients showed no reduction in AF incidence as compared to control group patients (7.04% versus 13.04%, respectively; p = 0.271). There was no statistically significant difference between the groups regarding death from any cause rate (5.6% versus 10.1%; p = 0,363) and hospital length of stay (14.5 ± 11.5 versus 13.3 ± 9.4 days; p = 0.490). However, colchicine group patients had a higher infection rate (26.8% versus 8.7%; p = 0.007). Conclusion: The use of colchicine to prevent AF after myocardial revascularization surgery was not effective in the present study. Brazilian Registry of Clinical Trials number RBR-556dhr.

Resumo O objetivo do artigo foi verificar a associação entre consumo alimentar, atividade física, fatores socioeconômicos e percentual de gordura corporal em escolares de 7 a 14 anos de idade. Estudo transversal realizado com amostra probabilística de 2481 escolares matriculados em escolas públicas e privadas de Florianópolis, Santa Catarina, Brasil. O percentual de gordura corporal foi investigado por meio das dobras cutâneas do tríceps e subescapular. Foram realizadas análises brutas e ajustadas por meio da regressão de Poisson, estimando-se razões de prevalência e intervalos de confiança de 95%. A prevalência do excesso de gordura corporal foi de 23,9%, não apresentando diferença significativa entre sexo (p = 0,359) e idade (p = 0,202). A gordura corporal associou-se a diferentes fatores nos escolares de 11 a 14 anos: consumir menos que 3 refeições ao dia (RP = 1,62; IC: 1,38-1,91) e alimento de risco mais que 3 vezes ao dia (RP = 0,61; IC: 0,47-0,79). Não foi observada diferença significativa com atividade física. A elevada prevalência de excesso de gordura corporal verificada evidencia a necessidade de estímulo à adoção de práticas comportamentais mais saudáveis (em relação à alimentação e à atividade física) pelos escolares.

Abstract The scope of this article was to assess the association between dietary intake, physical activity and socioeconomic factors associated with body fat percentage in 7 to 14-year-old schoolchildren. It is a cross-sectional study with a probability sample of 2,481 students from public and private schools in Florianópolis, Santa Catarina, Brazil. Body fat percentage was investigated by measuring triceps and subscapular skin folds. Poisson regression was performed to test the association between excess body fat and independent variables, estimating prevalence ratios and 95% confidence intervals. The prevalence of excess body fat was 23.9%, though there was no significant difference between sex (p = 0.359) and age (p = 0.202). Excess body fat was associated with different factors in 11 to 14-year-old schoolchildren, namely eating less than three meals a day (OR = 1.62, CI: 1.38 to 1.91) and consumption of high-risk food more than 3 times a day (OR = 0.61 CI: 0.47 to 0.79). No significant difference was observed with physical activity. The high prevalence of excess body fat detected reveals the need for fostering the adoption of healthier behavioral practices (in relation to nutrition and physical activity) by schoolchildren.

Resumo O objetivo do artigo foi verificar a associação entre consumo alimentar, atividade física, fatores socioeconômicos e percentual de gordura corporal em escolares de 7 a 14 anos de idade. Estudo transversal realizado com amostra probabilística de 2481 escolares matriculados em escolas públicas e privadas de Florianópolis, Santa Catarina, Brasil. O percentual de gordura corporal foi investigado por meio das dobras cutâneas do tríceps e subescapular. Foram realizadas análises brutas e ajustadas por meio da regressão de Poisson, estimando-se razões de prevalência e intervalos de confiança de 95%. A prevalência do excesso de gordura corporal foi de 23,9%, não apresentando diferença significativa entre sexo (p = 0,359) e idade (p = 0,202). A gordura corporal associou-se a diferentes fatores nos escolares de 11 a 14 anos: consumir menos que 3 refeições ao dia (RP = 1,62; IC: 1,38-1,91) e alimento de risco mais que 3 vezes ao dia (RP = 0,61; IC: 0,47-0,79). Não foi observada diferença significativa com atividade física. A elevada prevalência de excesso de gordura corporal verificada evidencia a necessidade de estímulo à adoção de práticas comportamentais mais saudáveis (em relação à alimentação e à atividade física) pelos escolares.

Abstract The scope of this article was to assess the association between dietary intake, physical activity and socioeconomic factors associated with body fat percentage in 7 to 14-year-old schoolchildren. It is a cross-sectional study with a probability sample of 2,481 students from public and private schools in Florianópolis, Santa Catarina, Brazil. Body fat percentage was investigated by measuring triceps and subscapular skin folds. Poisson regression was performed to test the association between excess body fat and independent variables, estimating prevalence ratios and 95% confidence intervals. The prevalence of excess body fat was 23.9%, though there was no significant difference between sex (p = 0.359) and age (p = 0.202). Excess body fat was associated with different factors in 11 to 14-year-old schoolchildren, namely eating less than three meals a day (OR = 1.62, CI: 1.38 to 1.91) and consumption of high-risk food more than 3 times a day (OR = 0.61 CI: 0.47 to 0.79). No significant difference was observed with physical activity. The high prevalence of excess body fat detected reveals the need for fostering the adoption of healthier behavioral practices (in relation to nutrition and physical activity) by schoolchildren.

Objetivos: Investigar a prevalência de inacurácia na estimação do tamanho corporal em escolares brasileiros de ambos os sexos com idade entre 7 e 10 anos e testar a associação com o sobrepeso/obesidade, excesso de gordura corporal e obesidade central. Métodos: A acurácia na estimação do tamanho corporal foi avaliada por meio da Escala de Silhuetas Brasileiras para crianças. As análises de associação foram realizadas por meio de regressão logística multinomial. Resultados: A prevalência geral de inacurácia na estimação do tamanho corporal foi de 76%, sendo que 34% das crianças subestimaram seu tamanho corporal e 42% o superestimaram. A obesidade medida por meio do índice de massa corporal foi associada a subestimação do tamanho corporal em ambos os sexos, enquanto que obesidade central se associou com superestimação do tamanho corporal apenas em meninas. Conclusões: Os resultados deste estudo demonstram uma elevada prevalência de inacurácia na estimação do tamanho corporal e sua associação com a obesidade. A acurácia na estimação do tamanho corporal é importante entre escolares obesos, pois pode ser o primeiro passo para a adoção de comportamentos mais saudáveis de vida.

Objectives: To investigate the prevalence of inaccurate estimation of own body size among Brazilian schoolchildren of both sexes aged 7-10 years, and to test whether overweight/obesity; excess body fat and central obesity are associated with inaccuracy. Methods: Accuracy of body size estimation was assessed using the Figure Rating Scale for Brazilian Children. Multinomial logistic regression was used to analyze associations. Results: The overall prevalence of inaccurate body size estimation was 76%, with 34% of the children underestimating their body size and 42% overestimating their body size. Obesity measured by body mass index was associated with underestimation of body size in both sexes, while central obesity was only associated with overestimation of body size among girls. Conclusions: The results of this study suggest there is a high prevalence of inaccurate body size estimation and that inaccurate estimation is associated with obesity. Accurate estimation of own body size is important among obese schoolchildren because it may be the first step towards adopting healthy lifestyle behaviors.

IntroductionKala-azar is a disease resulting from infection by Leishmania donovani and Leishmania infantum. Most patients with the disease exhibit prolonged fever, wasting, anemia and hepatosplenomegaly without complications. However, some patients develop severe disease with hemorrhagic manifestations, bacterial infections, jaundice, and edema dyspnea, among other symptoms, followed by death. Among the parasite molecules that might influence the disease severity are the macrophage migration inhibitory factor-like proteins (MIF1 and MIF2) and N-acetylglucosamine-1-phosphotransferase (NAGT), which act in the first step of protein N-glycosylation. This study aimed to determine whether MIF1, MIF2 and NAGT are virulence factors for severe kala-azar.MethodsTo determine the parasite genotype in kala-azar patients from Northeastern Brazil, we sequenced the NAGT genes of L. infantum from 68 patients as well as the MIF1 and MIF2 genes from 76 different subjects with diverse clinical manifestations. After polymerase chain reaction (PCR), the fragments were sequenced, followed by polymorphism identification.ResultsThe nucleotide sequencing of the 144 amplicons revealed the absence of genetic variability of the NAGT, MIF1 and MIF2 genes between the isolates. The conservation of these genes suggests that the clinical variability of kala-azar does not depend upon these genes. Additionally, this conservation suggests that these genes may be critical for parasite survival.ConclusionsNAGT, MIF1 and MIF2 do not alter the severity of kala-azar. NAGT, MIF1 and MIF2 are highly conserved among different isolates of identical species and exhibit potential for use in phylogenetic inferences or molecular diagnosis.