Alfred Schaeffer (1879-1957) was a German chemist who arrived in Minas Gerais in 1911 hired by the state government to organize the state health service in its newly established capital. He directed the Laboratory of Chemical Analysis of the State, and his analytical methods in dairy and mineral waters became a reference in Brazil. He also became professor of Chemistry at the new Faculty of Medicine of Belo Horizonte and founded the Chemistry Institute of the Engineering School in that city, influencing several students who became important names in Brazilian science. In addition, he was responsible for the assembly and technical coordination of pioneering industries in the dairy and wood distillation sector in the city of Santos Dumont. Later he assumed the post of technical director of Merck, also in Minas Gerais. Moving to Rio de Janeiro, he assumed a chair at the Technical School, working in teaching and research, and remained active even after retiring, publishing in important scientific journals. 18791957 1879 1957 (1879-1957 191 capital State Brazil science addition Dumont Merck Janeiro research retiring journals 1879195 187 195 (1879-195 19 187919 18 (1879-19 1 18791 (1879-1 (1879- (1879 (187 (18 (1 (

ABSTRACT Exposing seeds to agents that elicit tolerance to abiotic stress, such as phytohormones and organic acids, during hydration and dehydration cycles can determine their response to later stimuli, e.g. exposure to salt stress. The aim of this study was to evaluate the action of priming cycles with different eliciting agents of salt stress tolerance on seeds of the cowpea varieties Sempre Verde and Pingo de Ouro. The seeds were subjected to the following treatments: 0.0 mM NaCl (control); 100 mM NaCl (salt stress); salt stress + three seed-priming cycles (PC) in water; salt stress + PC in gibberellic acid; salt stress + PC in hydrogen peroxide; salt stress + PC in salicylic acid; salt stress + PC in ascorbic acid. The following variables were analysed: germination, growth, dry weight, salt tolerance index, total soluble sugars, total free amino acids and proline. Salt stress (100 mM NaCl) reduced germination, length and biomass accumulation in the Sempre Verde and Pingo de Ouro varieties. These showed the best response to the priming cycles with gibberellic and salicylic acids, which promoted greater germination potential, length and biomass under a salt stress of 100 mM NaCl, affording greater tolerance via osmotic regulation, especially in the Sempre Verde variety. stimuli eg e g e.g treatments 00 0 0. control (control) 10 stress) seedpriming seed (PC water acid peroxide analysed growth weight index sugars proline (10 potential regulation variety (control 1 (1 (

ABSTRACT Due to the importance of grain production, and the need to work the soil under limited moisture, the aim of this study was to develop computer software to predict the tractive capacity of wheeled tractors for two types of tyre, the effect of different inflation pressures and levels of soil moisture. A mathematical model was developed to predict the tractive capacity of a 4 x 2 AFT tractor. Software was developed and tested by comparing the computational data with those from tests of a working tractor in the field. The parameters under evaluation were drawbar force and front and rear drive wheel slip. At both moisture levels, the bias tyres had the lowest front to rear slip ratio at the lower pressure; the ratios were similar when equipped with radial tyres. The bias tyres show maximum force at a slip ratio of 1.09 at the higher pressure and 1.03 at the lower, while for the radial tyres the ratio was 1.05 at the higher pressure and 1.07 at the lower. Software was developed to process data from the model, with the results used for estimating the tractive force of the tractor. The tractive force was overestimated by the model, which needs further adjustment for direct application in the field. production tyre field 109 1 09 1.0 103 03 105 05 107 07 10 0 1.

Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the brain, and inhibiting this enzyme can reduce oxidative stress, stabilize neurotransmitter levels, and alleviate symptoms. In this context, a pharmacophoric model was created using PharmaGist with 31 hits extracted from BindingDB to enable a pharmacophoric-based search of potential MAO-B inhibitors in ZincPharmer’s chemical space, followed by the building of 10 conformers for each molecule in the software OMEGA, screening for structural and electrostatic similarity to safinamide using ROCS (Rapid overlay of chemical structures) and EON (Electrostatic similarity for lead-hopping), respectively. In addition, the molecular docking with Gold using the score function was performed to rank the ligands with the highest probabilities of affinity to MAO-B and then discriminate those with suitable physical chemical, pharmacokinetic, and toxicological features using the tools QikProp, SwissADME, and DEREK. Four potential ligands with selective MAO-B inhibitor properties were identified, which show promise as future therapeutic agents for MAO-B-related disorders. Worldwide schizophrenia depression diseases MAOB MAO (MAO-B brain stress levels symptoms context 3 pharmacophoricbased based ZincPharmers ZincPharmer s space 1 OMEGA Rapid structures Electrostatic leadhopping, leadhopping lead hopping , lead-hopping) respectively addition pharmacokinetic QikProp SwissADME DEREK identified MAOBrelated related disorders lead-hopping

Palygoskite pellets were synthesized with lignin and WAX® and subjected to technological characterization for application in the remediation of Pb ions contained in aqueous effluents. X-ray diffraction (XRD) characterization of the palygorskite:lignin:WAX® material in a proportion of 70:15:15 revealed that the heat treatment of the pellets did not compromise the crystalline structure of the palygoskite. Texture analyses demonstrated that the surface area increased after synthesis and heat treatment, thus increasing the adsorption capacity. Regarding porosity, X-ray microtomography revealed that the pellets exhibit an irregular and porous spherical morphology with interconnected pores. Adsorption tests showed a removal of 73% of PbII contained in aqueous effluents after 15 min, with equilibrium reached in 60 min (88.36%). After the adsorption process, the presence of lead in the material was qualitatively confirmed through scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM-EDS) images. The produced pellets exhibit promising adsorbent qualities, such as strength and effective PbII ion adsorption. WAX Xray X ray XRD (XRD palygorskiteligninWAX® palygorskiteligninWAX palygorskite palygorskite:lignin:WAX 701515 70 70:15:1 palygoskite capacity porosity pores 73 1 6 88.36%. 8836 88.36% . 88 36 (88.36%) process energydispersive energy dispersive SEMEDS SEM EDS (SEM-EDS images qualities 70151 7 70:15: 883 88.36 8 3 (88.36% 7015 70:15 88.3 (88.36 701 70:1 88. (88.3 70: (88. (88 (8 (

Caffeine (CAF) and nicotine (NIC) are emerging contaminants and are among the most consumed substances in the world, making it crucial to monitor these contaminants. In this work, an alternative electrolyte, 2-hydroxyethylammonium acetate (2HEAA) was used for the development of an electroanalytical method for determination and quantification of CAF and NIC, simultaneously, using differential pulse voltammetry (DPV). The system with the 2HEAA electrolyte was characterized by cyclic voltammetry and electrochemical impedance spectroscopy, and the DPV parameters were optimized for the best conditions. The method was validated from a calibration curve obtained which showed limit of detection (LOD) of 0.82 and 6.26 μmol L 1 and limit of quantification (LOQ) of 2.73 and 20.8 μmol L-1 for CAF and NIC, respectively. In the precision analyses, values lower than 10% of relative standard deviation were obtained. In the presence of concomitant inorganic and organic species, the system proved to be selective in the determination of analytes. The method was used to determine the analytes in fortified samples (river water, synthetic urine and commercial milk), obtaining recoveries between 87.25 and 111.40%. The 2HEAA demonstrated high efficiency as an alternative electrolyte with good signal-to-noise ratio, increased analytical sensitivity of the method, in addition to presenting low cost and fast electrolyte preparation. (CAF NIC (NIC world work 2hydroxyethylammonium hydroxyethylammonium 2 HEAA (2HEAA simultaneously DPV. . (DPV) spectroscopy conditions LOD (LOD 082 0 82 0.8 626 6 26 6.2 LOQ (LOQ 273 73 2.7 208 20 8 20. L1 L- respectively analyses 10 species river water milk, milk , milk) 8725 87 25 87.2 11140 111 40 111.40% signaltonoise signal noise ratio preparation (DPV 08 0. 62 6. 27 7 2. 872 87. 1114 11 4 111.40 111.4 111.

RESUMO: O estudo foi realizado em um ovino, fêmea, de três anos de idade, da raça santa inês, procedente de uma propriedade localizada do município de Santo Antônio de Tauá, oeste do Pará. O animal acometido tinha histórico de exoftalmia no olho esquerdo, secreção nasal e dificuldade respiratória há mais de três meses. Ao exame físico o animal apresentava baixo escore corporal, apatia, assimetria facial unilateral, moderada exoftalmia unilateral esquerda, dispneia mista e exsudação nasal serossanguinolenta profusa unilateral. À necropsia, foi observada grande massa nasal, predominantemente branco-amarelada com áreas vermelho enegrecidas, de superfície irregular, finamente granular, úmida e friável. A massa invadia desde a junção mucocutânea do nariz esquerdo até as coanas, se infiltrava pelos seios nasais frontais, placa cribiforme e alcançava as meninges e a porção frontal do cérebro. À microscopia da superfície do epitélio nasal notou-se severa destruição dos cornetos e dos epitélios, evidenciada por extensas áreas de necrose com muitos debris celulares, ulceração e infecção bacteriana secundária. No sistema nervoso central (SNC) havia meningite piogranulomatosa com acentuada congestão de vasos, focos de necrose e inflamação granulomatosa. O diagnóstico de rinite granulomatosa de origem micótica associada ao fungo Conidiobolus lamprauges foi baseado nos achados da imuno-histoquímica. RESUMO ovino fêmea idade inês Tauá Pará meses corporal apatia esquerda necropsia brancoamarelada branco amarelada enegrecidas irregular granular friável coanas frontais cérebro notouse notou epitélios celulares secundária SNC (SNC vasos imunohistoquímica. imunohistoquímica imuno histoquímica. histoquímica imuno-histoquímica

ABSTRACT: The study was conducted on a 3-year-old female Santa Inês sheep from a property located in the municipality of Santo Antônio de Tauá, west of Pará. The affected animal had a history of exophthalmos in the left eye, nasal discharge, and breathing difficulty for more than three months. On physical examination, the animal had a low body score, apathy, unilateral facial asymmetry, moderate unilateral left exophthalmos, mixed dyspnea and unilateral profuse serosanguinous nasal discharge. At necropsy, a large nasal mass was observed, predominantly yellowish-white with blackish-red areas, with an irregular, finely granular, moist, and friable surface. The mass invaded from the mucocutaneous junction of the left nostril to the choanae, infiltrated the frontal sinuses, the cribiform plate, and reached the meninges and the frontal portion of the brain. Microscopy of the surface of the nasal epithelium showed severe destruction of the turbinates and epithelia, evidenced by extensive areas of necrosis with a large amount of cellular debris, ulceration, and secondary bacterial infection. In the central nervous system there was pyogranulomatous meningitis with marked vessel congestion, as well as foci of necrosis and granulomatous inflammation. Immunohistochemistry showed intense staining of numerous intralesional hyphae for antibodies against Conidiobolus lamprauges. The diagnosis of granulomatous rhinitis of mycotic origin associated with the Conidiobolus lamprauges was based on epidemiological, clinical-pathological, and immunohistochemical data. ABSTRACT 3yearold yearold 3 year old Tauá Pará eye discharge months examination score apathy asymmetry necropsy observed yellowishwhite yellowish white blackishred blackish red irregular granular moist choanae sinuses plate brain epithelia debris ulceration infection congestion inflammation epidemiological clinicalpathological, clinicalpathological clinical pathological, pathological clinical-pathological data

Resumo O concreto têxtil surge como uma alternativa para o reforço de estruturas de concreto armado. Porém, por ser um material relativamente novo, inexiste ainda um órgão ou norma regulamentadora que uniformize os processos de fabricação e de aplicação do material, o que gera diferenças significativas quanto às suas características e propriedades. Sob esta perspectiva, este estudo busca avaliar experimentalmente o desempenho mecânico do concreto têxtil ao ser aplicado como reforço de vigas em concreto armado submetidas ao ensaio de flexão a quatro pontos, utilizando o têxtil de fibra de vidro álcali-resistente de produção brasileira TEXIGLASS AR-360-RA-04. De caráter exploratório, o programa experimental é composto por quatorze vigas reforçadas e uma viga testemunho de seção retangular (120 mm de largura, 200 mm de altura e 1500 mm de comprimento), totalizando quinze vigas. Como variáveis, investigam-se a resistência de ligação na interface têxtil-matriz a partir do (a) tipo de matriz (argamassa polimérica industrializada ou argamassa autoadensável) e do (b) tratamento superficial do têxtil em quatro configurações: têxtil sem revestimento (SR), revestido com epóxi (E), totalmente revestido com epóxi e areia (EA) ou totalmente revestido com epóxi, mas com areia somente nas extremidades (EAP). A partir dos resultados, verificou-se principalmente que: todas as vigas reforçadas apresentaram aumentos da (a) capacidade resistente, (b) ductilidade e (c) tenacidade. Apesar da grande variabilidade de resultados, a técnica de revestimento nos exemplares dos têxteis EAP se mostrou promissora. Porém novo propriedades perspectiva pontos álcaliresistente álcali resistente AR360RA04. AR360RA04 ARRA AR 360 RA 04. 04 AR-360-RA-04 exploratório 120 (12 largura 20 150 comprimento, comprimento , comprimento) variáveis investigamse investigam têxtilmatriz (a autoadensável b (b configurações SR, SR (SR) E, E (E) EA (EA EAP. . (EAP) resultados verificouse verificou c (c tenacidade promissora AR360RA0 36 0 AR-360-RA-0 12 (1 2 15 (SR (E (EAP AR360RA 3 AR-360-RA- 1 ( AR-360-RA

Abstract Textile reinforced concrete emerges as an alternative for the strengthening of reinforced concrete structures. However, as a relatively new material, there is still no regulatory body or standardization that standardizes the manufacturing and application processes of the material, which generates significant differences regarding its characteristics and properties. From this perspective, this study seeks to experimentally evaluate the mechanical performance of textile reinforced concrete when applied as reinforcement of reinforced concrete beams subjected to four-point bending tests, using the alkali-resistant fiberglass textile produced in Brazil, TEXIGLASS AR-360-RA-04. As an exploratory study, the experimental program consists of fourteen reinforced beams and one rectangular cross-section reference beam (120 mm wide, 200 mm high, and 1500 mm long), totaling fifteen beams. As variables, the bond strength at the textile-matrix interface is investigated based on (a) the type of matrix (industrialized polymer mortar or self-compacting mortar) and (b) the surface treatment of the textile in four configurations: uncoated textile (UT), coated with epoxy (E), fully coated with epoxy and sand (ES) or fully coated with epoxy and partial sand (EPS). From the results, it was mainly found that: all reinforced beams showed increases in (a) load-carrying capacity, (b) ductility and (c) toughness. Despite the great variability of results, the coating technique in the EPS textile specimens proved promising. structures However material properties perspective fourpoint point tests alkaliresistant alkali resistant Brazil AR360RA04. AR360RA04 ARRA AR 360 RA 04. 04 AR-360-RA-04 crosssection cross section 120 (12 wide 20 high 150 long, long , long) variables textilematrix (a industrialized selfcompacting self compacting b (b configurations UT, UT (UT) E, E (E) ES (ES EPS. . (EPS) results loadcarrying load carrying capacity c (c toughness promising AR360RA0 36 0 AR-360-RA-0 12 (1 2 15 (UT (E (EPS AR360RA 3 AR-360-RA- 1 ( AR-360-RA

Abstract In this technical note, we present an unprecedented database that solves a major problem in the study of electoral strategies: The lack of data to identify where, when, and how candidates carry out activities during the electoral campaign. The Superior Electoral Court (TSE) has made available the records of income and spending during each candidate’s campaign. Among the many pieces of information contained therein, we collected the bank and branch numbers of the beneficiaries of the transactions indicated by the candidates and cross-referenced them with a list of bank branch addresses in Brazil. From these cross-references, we were able to georeference the spending of candidates for the national legislature for the whole country and thus build a proxy of campaign strategies in the electoral contest. This unprecedented database will allow us to advance our understanding of how electoral campaigns are designed, what strategies are employed, and how the relationship between representatives and citizens takes place, since it will be possible to dissociate campaign efforts from the outcome of the election. note where when TSE (TSE candidate s therein crossreferenced cross referenced Brazil crossreferences, crossreferences references, references cross-references contest designed employed place election

Resumo

Resumen En esta nota técnica, presentamos una base de datos sin precedentes que soluciona un gran problema en el estudio de las estrategias electorales: la falta de datos que permitan identificar dónde, cuándo y cómo los candidatos realizan actividades durante la campaña electoral. El Tribunal Supremo Electoral (TSE) ha puesto a disposición de los ciudadanos los registros de ingresos y gastos durante la campaña de cada candidato. Entre las muchas informaciones que contienen, recogimos los números de banco y de sucursal de los beneficiarios de las transacciones indicadas por los candidatos y los cruzamos con una lista de direcciones de sucursales bancarias en Brasil. A partir de estas referencias cruzadas, pudimos georreferenciar los gastos de los candidatos a las legislativas nacionales para todo el país y construir así un proxy de las estrategias de campaña en la contienda electoral. Esta base de datos sin precedentes nos permitirá avanzar en la comprensión de cómo se construye la campaña electoral, qué estrategias se emplean y también cómo se produce la relación entre representantes y ciudadanos, ya que será posible disociar los esfuerzos de campaña del resultado de las elecciones. técnica electorales dónde electoral TSE (TSE candidato contienen Brasil cruzadas elecciones

Résumé Dans cette note technique, nous introduisons une base de données innovante qui résout une lacune importante dans l’étude des stratégies électorales : l’absence de données permettant d’identifier où, quand et comment les candidats réalisent des activités pendant la campagne électorale. Le Tribunal Supérieur Électoral (TSE) a rendu disponibles les enregistrements des revenus et des dépenses de chaque candidat pendant la campagne. Parmi les nombreuses informations contenues, nous avons collecté le numéro de la banque et de l’agence du bénéficiaire des transactions indiquées par les candidats et les avons croisés avec une liste d’adresses des agences bancaires au Brésil. Grâce à ces croisements, nous avons pu géoréférencer les dépenses des candidats au législatif national pour tout le pays et ainsi construire une proxy des stratégies de campagne dans la compétition électorale. Cette nouvelle base de données nous permettra de mieux comprendre comment se structurent les campagnes électorales, les stratégies adoptées, et la relation entre les représentants et les citoyens, en permettant de dissocier les efforts de campagne des résultats électoraux. technique létude l étude labsence absence didentifier d identifier où électorale TSE (TSE contenues lagence agence dadresses adresses Brésil croisements adoptées citoyens électoraux

RESUMO: Uma das causas de perda de produtividade em lavouras de cana está associada à espécie Diatraea saccharalis, também conhecida por broca da cana. Portanto, este estudo avaliou a viabilidade do uso de sensores hiperespectrais para obter a resposta espectral foliar da cana-de-açúcar em diferentes períodos de infestações, tanto a nível foliar quanto dossel, a fim de diagnosticar antecipadamente os danos da Diatraea saccharalis. O estudo contou com três variedades de cana-de-açúcar: CTC9003BT, CTC4 e RB966928. Em metade das parcelas foi utilizado o inseticida Altacor® para o controle de pragas. As coletas de dados ocorreram nas fases: brotação, perfilhamento, crescimento de colmos e início da maturação. Para avaliar os efeitos da broca na cana foi coletado os dados referentes ao conteúdo relativo de água (CRA), assinatura espectral foliar em laboratório e dossel, índices de vegetação (NDVI e MCARI), produtividade, pureza e ATR (Açúcar Total Recuperável). O maior CRA encontrado foi para a CTC9003BT (60,15%) sem inseticida e 59,0% com inseticida. As faixas espectrais do visível (400-680 nm) e infravermelho próximo (750-1300 nm) identificaram variações espectrais nas plantas com e sem broca. O percentual de broca apresentou correlações altas e negativas entre a produtividade, NDVI e ATR, com coeficientes de -0,68, -0,76 e -0,76, respectivamente. Os índices NDVI e MCARI foram eficazes na detecção de plantas sob estresse, contudo, sua variação é influenciada por múltiplos fatores, sendo difícil associá-los a um único problema (broca). RESUMO saccharalis Portanto canadeaçúcar açúcar infestações dossel CTCBT CTC BT RB966928 RB Altacor pragas fases brotação perfilhamento maturação CRA, , (CRA) MCARI, MCARI) Açúcar Recuperável. Recuperável . Recuperável) 60,15% 6015 60 15 (60,15% 590 59 0 59,0 400680 400 680 (400-68 nm 7501300 750 1300 (750-130 0,68, 068 68 -0,68 0,76 076 76 -0,7 0,76, respectivamente estresse contudo fatores associálos associá los (broca) RB96692 (CRA 60,15 601 6 1 (60,15 5 59, 40068 40 (400-6 750130 75 130 (750-13 0,68 06 -0,6 0,7 07 7 -0, (broca RB9669 60,1 (60,1 4006 4 (400- 75013 13 (750-1 0,6 0, -0 RB966 60, (60, (400 7501 (750- - RB96 (60 (40 (750 RB9 (6 (4 (75 ( (7

ABSTRACT: One of the causes of productivity loss in sugarcane cultivation has been associated with the species Diatraea saccharalis, also known as the sugarcane borer. Therefore, this study evaluated the feasibility of using hyperspectral sensors to obtain the leaf spectral response of sugarcane in different periods of infestation at leaf and canopy levels to diagnose D. saccharalis damage in advance. The study included three varieties of sugarcane: CTC9003BT, CTC4, and RB966928. The insecticide Altacor® was used to control pestsin half of the plots. Data collection occurred at the following stages: sprouting, tillering, stalke longation, and early maturation. Data regarding relative water content (RWC), leaf spectral signature in the laboratory and canopy, vegetation indices (NDVI and MCARI), productivity, purity, and total recoverable sugar (TRS) were collected to evaluate the borer effects on the sugarcane crop. The highest RWC was observed for CTC9003BT (60.15%) without insecticide and 59.0% with insecticide. The visible (400-680 nm) and near-infrared (750-1300 nm) spectral bands identified spectral variations in plants with and without sugarcane borer. The percentage of sugarcane borer showed high and negative correlations between productivity, NDVI, and TRS, with coefficients of -0.68, -0.76, and -0.76, respectively. The NDVI and MCARI indices effectively detect plants under stress, but their variation is influenced by multiple factors, making it difficult to associate them with a single problem (sugarcane borer). ABSTRACT Therefore D advance CTCBT CTC BT CTC4 RB966928 RB Altacor plots stages sprouting tillering longation maturation RWC, , (RWC) MCARI, MCARI) purity TRS (TRS crop 60.15% 6015 60 15 (60.15% 590 59 0 59.0 400680 400 680 (400-68 nm nearinfrared near infrared 7501300 750 1300 (750-130 0.68, 068 68 -0.68 0.76, 076 76 -0.76 respectively stress factors . borer) RB96692 (RWC 60.15 601 6 1 (60.15 5 59. 40068 40 (400-6 750130 75 130 (750-13 0.68 06 -0.6 0.76 07 7 -0.7 RB9669 60.1 (60.1 4006 4 (400- 75013 13 (750-1 0.6 -0. 0.7 RB966 60. (60. (400 7501 (750- 0. -0 RB96 (60 (40 (750 - RB9 (6 (4 (75 ( (7

Resumen Marco contextual: Las ambulancias de soporte vital inmediato (SVI) permiten al personal de enfermería intervenir en un contexto prehospitalario, con el apoyo de sus conocimientos técnico-científicos y de complejos protocolos de actuación y regulación médica a través de la telemedicina. Objetivo: Analizar las aportaciones de la intervención del personal de enfermería del SVI en la evolución del estado clínico de la persona en situación crítica (PSC). Metodología: Estudio cuantitativo, descriptivo-correlacional, retrospectivo, realizado en centros de SVI del norte de Portugal. Se analizaron 574 historias clínicas electrónicas entre el 1 de noviembre y el 31 de diciembre de 2019, correspondientes al mismo número de personas evaluadas. Se utilizó la escala National Early Warning Score (NEWS) para evaluar la evolución clínica de la PSC. Resultados: Se observó una evolución positiva en el score NEWS de la PSC, tras la intervención del personal de enfermería del SVI (M = 4,43 ± 3,901 vs 3,34 ± 3,329; sig < 0,001). Por el contrario, el riesgo clínico disminuyó significativamente tras la intervención del personal de enfermería. Conclusión: Se demostró la relevancia de la intervención del personal de enfermería del SVI en el contexto prehospitalario, como garantía de seguridad, calidad y mejora continua en la atención a la PSC.

Resumo Enquadramento: As ambulâncias de suporte imediato de vida (SIV) possibilitam ao enfermeiro capacidade de intervenção em contexto pré-hospitalar, suportada pelo seu conhecimento técnico-científico, protocolos complexos de atuação e regulação médica por telemedicina. Objetivo: Analisar os contributos da intervenção dos enfermeiros SIV, na evolução do estado clínico da pessoa em situação crítica (PSC). Metodologia: Estudo quantitativo, descritivo-correlacional, retrospetivo, realizado em meios SIV, na região norte de Portugal. Analisados 574 registos clínicos eletrónicos, entre 01 de novembro e 31 de dezembro de 2019, que correspondem ao mesmo número de pessoas avaliadas. Utilizada a escala National Early Warning Score (NEWS) para avaliar a evolução clínica da PSC. Resultados: Observou-se uma evolução positiva do score NEWS da PSC, após a intervenção do enfermeiro SIV (M = 4,43 ± 3,901 vs 3,34 ± 3,329; sig < 0,001). Em sentido inverso, o risco clínico diminuiu significativamente após a intervenção do enfermeiro. Conclusão: Demonstrou-se a relevância da intervenção do enfermeiro SIV no contexto pré-hospitalar, enquanto garantia de segurança, qualidade e melhoria contínua dos cuidados à PSC.

Abstract Background: Immediate life support (ILS) ambulances allow nurses to intervene in pre-hospital settings, supported by their technical-scientific knowledge and complex protocols of action and regulation through telemedicine. Objective: To analyze the contributions of nursing interventions in the evolution of the clinical state of critical patients. Methodology: Quantitative, descriptive-correlational, retrospective, and observational study conducted in ILS settings in northern Portugal. A total of 574 electronic clinical records were analyzed between 1 November and 31 December 2019, corresponding to the same number of people evaluated. The National Early Warning Score (NEWS) was used to assess the clinical evolution of critical patients. Results: There was a positive evolution of the NEWS score of critical patients after the intervention of ILS nurses (M = 4.43 ± 3.901 vs. 3.34 ± 3.329; sig < 0.001). Similarly, the clinical risk of critical patients decreased after the nurse’s intervention. Conclusion: This study demonstrated the importance of nurses in prehospital care, as a guarantee of safety, quality, and continuous improvement of care for critical patients.

Abstract This research aims to investigate the syntactic representation of the perfect aspect. More specifically, we intend to verify the morphosyntactic realizations of universal perfect (UP), resultative perfect (ResP) and experiential perfect (ExP) associated to the past and to the indicative mood in Brazilian Portuguese (BP). For this purpose, five hours of spontaneous speech were analyzed and a gap-filling task was applied to 62 native speakers of BP. The results evidenced that UP is conveyed by the imperfective past and the auxiliary verb “estar” (‘to be’) in the imperfective past + gerund; ResP is conveyed by past perfect (with the auxiliary verbs “ter” (‘to have’) and “haver” (‘there to be’), simple past, past perfect simple and “acabar” (‘to finish’) in the past perfect compound with the auxiliary verb “ter” (‘to have’) + ‘de’ (‘of’) + infinitive; and ExP is conveyed by the past perfect compound with the auxiliary verbs “ter” (‘to have’) and “haver” (‘there to be’), simple past and past perfect simple. We discussed that the results corroborate Rodrigues and Martins’s (2019) proposal that there are three perfect phrases in the syntactic tree: Universal Perfect Phrase (UPerfP) to UP, Resultative Perfect Phrase (ResPerfP) to ResP, and Experiential Perfect Phrase (ExPerfP) to ExP.

Resumo Objetiva-se, nesta pesquisa, investigar a representação sintática do aspecto perfect. Mais especificamente, pretende-se verificar as realizações morfossintáticas de perfect universal (PU), resultativo (PRes) e experiencial (PEx) associados ao tempo passado e ao modo indicativo no português brasileiro (PB). Para tanto, foram analisadas cinco horas de fala espontânea e foi aplicado um teste de preenchimento de lacunas a 62 falantes nativos do PB. Os resultados evidenciam que o PU é veiculado por meio de pretérito imperfeito e “estar” no pretérito imperfeito + gerúndio; o PRes é veiculado por meio de pretérito mais-que-perfeito composto (com auxiliares “ter” e “haver”), pretérito perfeito, pretérito mais-que-perfeito simples e “acabar” no pretérito mais-que-perfeito composto com auxiliar “ter” + preposição “de” + infinitivo; e o PEx é veiculado por meio de pretérito mais-que-perfeito composto (com auxiliares “ter” e “haver”), pretérito perfeito e pretérito mais-que-perfeito simples. Os resultados corroboram a proposta de Rodrigues e Martins (2019) de que há três sintagmas de perfect na árvore sintática: o Sintagma de Perfect Universal (UPerfP) para o PU, o Sintagma de Perfect Resultativo (ResPerfP) para o PRes e o Sintagma de Perfect Experiencial (ExPerfP) para o PEx.

Abstract Introduction: Hereditary transthyretin amyloidosis (ATTRv) is a severe autosomal dominant systemic disease. It affects the peripheral and autonomic nervous systems, heart, kidneys, and eyes. Amyloid deposition has been demonstrated in the glomerular and tubulointerstitial compartments of the kidney. Therefore, urinary acidification disorders such as renal tubular acidosis (RTA) may be early manifestations of renal involvement in this population. Objective: To evaluate the prevalence of RTA in individuals with ATTRv. Methods: We included symptomatic and asymptomatic individuals with TTR mutation, older than 18 years, GFR >45 mL/min/1.73m2, without systemic metabolic acidosis. Urinary acidification protocol was performed with furosemide and fludrocortisone after 12 h of water deprivation (water deprivation test - WDT) and measurements of urine ammonium ( UNH 4 +) and titratable acidity (UTA). Proximal RTA (pRTA) was diagnosed when FEHCO3>10%. Incomplete form distal RTA (dRTA) was diagnosed if UpH>5.3. Results: We selected 49 individuals with a mean age of 40 (35.5–56.5) years, 63% of which were female, 84% were Caucasian, and mean GFR was 85.5 ± 20.5 mL/min/1.73m2. 94% had the genetic variant Val50Met and 57% were symptomatic. The prevalence of pRTA was 2% and of dRTA was 16.3%. In the subgroup with dRTA, there was no significant increase in excretion of UNH 4 + and UTA. We observed a good correlation between UpH by potentiometry and UpH dipstick. A UpH<5.5 on the dipstick had 100% sensitivity and negative predictive value to exclude dRTA. Conclusion: A high prevalence of RTA was found in individuals with TTR mutations. The UpH dipstick after WDT had good accuracy for screening for dRTA. Further studies are needed to evaluate the impact of early diagnosis and treatment of RTA in this population. Introduction ATTRv (ATTRv disease systems heart kidneys eyes kidney Therefore (RTA population Objective Methods mutation 1 years 45 >4 mLmin173m2 mLminm mL min 73m2 m mL/min/1.73m2 UTA . (UTA) (pRTA FEHCO310 FEHCO FEHCO3 10 FEHCO3>10% (dRTA UpH53 5 3 UpH>5.3 Results 35.5–56.5 355565 35 56 (35.5–56.5 63 female 84 Caucasian 855 85 85. 205 20 20. 94 ValMet Val Met 57 2 163 16 16.3% UpH55 UpH<5. 100 Conclusion mutations > mLmin mLmin173m 73m mL/min/1.73m (UTA FEHCO31 FEHCO3>10 UpH5 UpH>5. 35.5–56. 35556 (35.5–56. 6 8 9 16.3 UpH<5 FEHCO3>1 UpH>5 35.5–56 3555 (35.5–56 16. UpH< FEHCO3> UpH> 35.5–5 355 (35.5–5 35.5– (35.5– 35.5 (35.5 35. (35. (35 (3

Resumo Introdução: A amiloidose hereditária por transtirretina (ATTRv) é uma doença sistêmica autossômica dominante grave. Afeta os sistemas nervoso periférico e autônomo, coração, rins e olhos. A deposição de amiloide foi demonstrada nos compartimentos glomerular e tubulointersticial do rim. Portanto, distúrbios de acidificação urinária, como acidose tubular renal (ATR), podem ser manifestações precoces de envolvimento renal nessa população. Objetivo: Avaliar a prevalência de ATR em indivíduos com ATTRv. Métodos: Incluímos indivíduos sintomáticos e assintomáticos com mutação na TTR, maiores de 18 anos, TFG >45 mL/min/1,73m2, sem acidose metabólica sistêmica. Realizou-se protocolo de acidificação urinária com furosemida e fludrocortisona após 12 horas de privação hídrica (teste de restrição hídrica - TRH) e medições de amônia urinária ( uNH 4 +) e acidez titulável (uTA) na urina. ATR proximal (ATRp) foi diagnosticada quando FEHCO3>10%. ATR distal (ATRd) de forma incompleta foi diagnosticada se pHu>5,3. Resultados: Selecionamos 49 indivíduos com idade média de 40 (35,5–56,5) anos, 63% mulheres, 84% caucasianos e TFG média de 85,5 ± 20,5 mL/min/1,73m2. 94% apresentaram a variante genética Val50Met; 57% eram sintomáticos. A prevalência de ATRp foi 2% e a de ATRd foi 16,3%. No subgrupo com ATRd, não houve aumento significativo na excreção de uNH 4 + e uTA. Observamos uma boa correlação entre pHU por potenciometria e pHU por fita reagente. Um pHU<5,5 na fita reagente apresentou 100% de sensibilidade e valor preditivo negativo para excluir a ATRd. ConclusÃO: Uma alta prevalência de ATR foi encontrada em indivíduos com mutações na TTR. O pHU por fita reagente após TRH teve boa precisão para triagem de ATRd. São necessários mais estudos para avaliar o impacto do diagnóstico e tratamento precoces da ATR nessa população. Introdução ATTRv (ATTRv grave autônomo coração olhos rim Portanto ATR, , (ATR) população Objetivo Métodos TTR 1 anos 45 >4 mLmin173m2 mLminm mL min 73m2 m mL/min/1,73m2 Realizouse Realizou teste uTA (uTA urina (ATRp FEHCO310 FEHCO FEHCO3 10 FEHCO3>10% (ATRd pHu53 pHu 5 3 pHu>5,3 Resultados 35,5–56,5 355565 35 56 (35,5–56,5 63 mulheres 84 855 85 85, 205 20 20, 94 Val50Met ValMet Val Met 57 2 163 16 16,3% pHU55 pHU<5, 100 ConclusÃO (ATR > mLmin mLmin173m 73m mL/min/1,73m FEHCO31 FEHCO3>10 pHu5 pHu>5, 35,5–56, 35556 (35,5–56, 6 8 9 16,3 pHU5 pHU<5 FEHCO3>1 pHu>5 35,5–56 3555 (35,5–56 16, pHU< FEHCO3> pHu> 35,5–5 355 (35,5–5 35,5– (35,5– 35,5 (35,5 35, (35, (35 (3

Resumo: Introdução: A morte faz parte dos tabus sociais existentes e pode fomentar atitudes que se distanciam de sua abordagem explícita em relação aos cuidados. Objetivo: analisar as atitudes diante da morte em profissionais de enfermagem de acordo com as publicações científicas no contexto latino-americano no período de 2018 a 2022. Metodologia: Foi realizada uma revisão de literatura integrativa de publicações científicas latino-americanas sobre atitudes diante da morte no contexto da enfermagem, utilizando os seguintes termos padronizados: atitude, morte, enfermagem e cuidados de enfermagem. Foram incluídos 8 artigos publicados no período definido, em espanhol e português, nos quais o tema da revisão foi abordado explicitamente. As informações dos artigos foram analisadas tendo como referência os conceitos da teoria das transições. Resultados: Foram identificados desenhos quantitativos (50 %) e qualitativos (50 %), elaborados totalmente no âmbito hospitalar. Os principais resultados mostram a predominância da indiferença diante da morte no contexto do cuidado. Em relação à teoria das transições, a maioria dos artigos aborda as condições em que as transições ocorrem, além dos conceitos de terapêutica de enfermagem e padrões de resposta. Conclusões: A produção de pesquisas sobre atitudes diante da morte em profissionais de enfermagem é escassa na América Latina. As experiências de perdas próximas, a capacitação e o apoio institucional são a base para contribuir para uma melhor atitude em relação à morte

Abstract: Introduction: Death is part of the existing social taboos and can foster attitudes that are far from its explicit approach in relation to care. Objective: To analyze attitudes towards death in nursing professionals according to scientific publications in the Latin American context in the period 2018 to 2022. Methodology: An integrative literature review was conducted of Latin American scientific publications regarding attitudes towards death in the context of Nursing, using the following standardized terms: attitude, death, nursing and nursing care. Eight articles published in the defined period were included, in Spanish and Portuguese, in which the subject of the review was explicitly addressed. The information in the articles was analyzed using the concepts of the theory of transitions as a reference. Results: Both quantitative (50 %) and qualitative (50 %) designs were found, all of them elaborated in the hospital setting. The main results show the predominance of indifference to death in the context of care. In relation to the theory of transitions, most of the articles address the conditions under which these occur, in addition to the concepts of nursing therapeutics and response patterns. Conclusions: The production of research on the attitude towards death in nursing professionals is scarce in Latin America. Experiences of close losses, training and institutional support are the basis for contributing to a better attitude towards death

Resumen: Introducción: La muerte es parte de los tabúes sociales existentes y puede fomentar actitudes que distan de su abordaje explícito en relación con los cuidados. Objetivo: Analizar las actitudes ante la muerte en profesionales de enfermería de acuerdo con las publicaciones científicas en el contexto latinoamericano en el período 2018 a 2022. Metodología: Se realizó una revisión de literatura integrativa de las publicaciones científicas latinoamericanas respecto de las actitudes ante la muerte en el contexto de la enfermería, empleando los siguientes términos estandarizados: actitud, muerte, enfermería y cuidados de enfermería. Se incluyeron 8 artículos publicados en el período definido, en idioma español y portugués, en los que se abordó explícitamente la temática de la revisión. La información de los artículos fue analizada tomando como referencia los conceptos de la teoría de las transiciones. Resultados: Se encontraron diseños tanto cuantitativos (50 %) como cualitativos (50 %), elaborados en su totalidad en el ámbito hospitalario. Los principales resultados dan cuenta del predominio de la indiferencia ante la muerte en el contexto de los cuidados. En relación con la teoría de las transiciones, la mayoría de los artículos abordan las condiciones en que estas se dan, además de los conceptos de terapéutica de enfermería y patrones de respuesta. Conclusiones: La producción de investigaciones sobre la actitud ante la muerte en profesionales de enfermería es escasa en Latinoamérica. Las experiencias de pérdidas cercanas, la capacitación y el soporte institucional son la base para contribuir a una mejor actitud hacia la muerte

Abstract Background: Healthcare-associated infections are a prevalent issue in health systems that affect everyone. The incidence and prevalence of healthcare-associated infections depend on the context in which they occur. An example of this is ventilator-associated pneumonia in intensive care units. Objective: To analyze the determinants of ventilator-associated pneumonia in an intensive care unit of a central hospital in northern Portugal. Methodology: A retrospective, descriptive-correlational quantitative study was conducted with 705 patients admitted to the ICU of the hospital under investigation. Results: The results show that male gender, previous antibiotic use, endotracheal reintubation, level of consciousness, cuff pressure, ventilation time, injury, poisoning, and certain other consequences of external causes as admitting diagnosis are among the determinants of ventilator-associated pneumonia. Moreover, the incidence of ventilator-associated pneumonia was of 4.5%. Conclusion: The study recommends the judicious use of antibiotics, limiting the duration of invasive ventilation, implementing ventilator weaning protocols, and auditing compliance with the care bundle for ventilator-associated pneumonia. This study sheds light on the prevention of ventilator-associated pneumonia and its recommendations contribute to better care and more effective and safer nursing interventions.

Resumo Enquadramento: As infeções associadas aos cuidados de saúde (IACS) são uma problemática atual dos sistemas de saúde variando a sua incidência, prevalência do contexto de cuidados. A pneumonia associada à ventilação (PAV) é disso um exemplo ocorrendo em unidades de cuidados intensivos (UCI). Objetivo: Analisar determinantes da PAV, em doentes internados numa UCI de um hospital central do norte de Portugal. Metodologia: Estudo descritivo-correlacional e retrospetivo, com base nos registos de 705 doentes internados na UCI. Resultados: Constituíram-se determinantes da PAV o sexo masculino, tratamento prévio com antibiótico, reintubação endotraqueal, nível de consciência, pressão de cuff, tempo de ventilação, diagnóstico de entrada lesões, envenenamento e algumas outras consequências de causas externas. A incidência de PAV foi de 4,5%. Conclusão: O uso criterioso de antibióticos, o menor tempo possível de ventilação invasiva, a implementação de protocolos de desmame ventilatório e auditorias ao cumprimento da bundle da PAV podem contribuir para melhores cuidados e intervenções de enfermagem mais eficazes e seguras.

Resumen Marco contextual: Las infecciones asociadas a los cuidados sanitarios (IACS) son un problema actual en los sistemas sanitarios, y su incidencia y prevalencia varían en función del entorno asistencial. Un ejemplo de ello es la neumonía asociada a la ventilación mecánica (PAV), que se da en las unidades de cuidados intensivos (UCI). Objetivo: Analizar los determinantes de la PAV en pacientes ingresados en la UCI de un hospital central del norte de Portugal. Metodología: Estudio descriptivo-correlacional y retrospectivo, basado en los registros de 705 pacientes ingresados en la UCI. Resultados: Los factores determinantes de la PAV fueron el sexo masculino, el tratamiento antibiótico previo, la reintubación endotraqueal, el nivel de consciencia, la presión del manguito, el tiempo de ventilación, el diagnóstico de entrada de lesiones, la intoxicación y algunas otras consecuencias de causas externas. La incidencia de PAV fue del 4,5%. Conclusión: El uso prudente de antibióticos, el menor tiempo posible de ventilación invasiva, la aplicación de protocolos de destete del ventilador y las auditorías de cumplimiento del paquete de PAV pueden contribuir a mejorar los cuidados y a que las intervenciones de enfermería sean más eficaces y seguras.