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ABSTRACT A young woman presented at our clinic with sudden visual loss in the right eye, recurrent vertigo, and right-sided tinnitus. We performed a complete ophthalmological evaluation. This revealed effects of the condition on the small arterioles of the peripheral retina. Susac syndrome is characterized by the clinical triad of retinal arteriolar occlusions, cochleovestibular manifestations, and encephalopathy (which can be identified by neuroimaging abnormalities). Early diagnosis and immunosuppressive therapy improved the patient's visual acuity and the remission of her other symptoms. Hemi-central retinal artery occlusion is an atypical neuro-ophthalmological finding in this disease. However, its identification as a sign of Susac syndrome may facilitate timely diagnosis and accurate treatment. eye vertigo rightsided sided tinnitus evaluation retina occlusions manifestations which abnormalities. abnormalities . abnormalities) patients patient s symptoms Hemicentral Hemi central neuroophthalmological neuro disease However treatment

https://doi.org/10.5935/0004-2749.2022-0195

Knowledge of Brazilian Dentists about Dentoalveolar Trauma Care and their Experiences during the COVID-19 Pandemic COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Soares, Lívia Pessamílio

; Scalioni, Flávia Almeida Ribeiro

; Fiche, Gabriela El-Corab

; Procópio, Stefânia Werneck

; Carrada, Camila Faria

; Fernandes, Raphaella Barcellos

; Campos, Marcio José da Silva

; Machado, Fernanda Campos

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2024, Volume 24 elocation e230042

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To assess dentists' knowledge from Minas Gerais, Brazil, about dentoalveolar trauma (DT) and their experiences during the COVID-19 pandemic. Material and Methods: An online questionnaire with 34 questions was applied to collect personal data, professional training, self-assessment of experience/knowledge about DT, experience in care provided during the social distancing, and knowledge/conduct. The specific responses were evaluated based on the guidelines of the International Association of Dental Traumatology (IADT). Descriptive analysis and Pearson's chi-square test were performed. The level of significance was set at p≤0.05. Results: Most professionals (97.7%) had received information on DT, and only 4.6% of the participants considered their knowledge poor or very poor. However, 92.7% felt the need for more information on the subject. Regarding experiences during the pandemic, 55.7% provided trauma care during that period. Forty percent of the consultations were performed in person, and 33.3% of the professionals noted an increase in cases during the pandemic; 56.6% reported that the frequency did not change. The overall mean number of correct answers about DT was 5.29±2.11, indicating an acceptable level of knowledge. The mean percentage of hits for the specific questions was 44.1%. Conclusion: Although the level of knowledge of the dentists evaluated was acceptable, some aspects were deficient, with the need for more information about the IADT guidelines. Objective Gerais Brazil (DT COVID19 COVID 19 COVID-1 pandemic Methods 3 data training selfassessment self assessment experienceknowledge distancing knowledgeconduct conduct knowledge/conduct IADT. . (IADT) Pearsons Pearson s chisquare chi square p005 p 0 05 p≤0.05 Results 97.7% 977 97 7 (97.7% 46 4 6 4.6 However 927 92 92.7 subject 557 55 55.7 period person 333 33 33.3 566 56 56.6 change 529211 5 29 2 11 5.29±2.11 441 44 1 44.1% Conclusion deficient COVID1 COVID- (IADT p00 p≤0.0 97.7 9 (97.7 4. 92. 55. 33. 56. 52921 5.29±2.1 44.1 p0 p≤0. 97. (97. 5292 5.29±2. 44. p≤0 (97 529 5.29±2 p≤ (9 52 5.29± ( 5.29 5.2 5.

https://doi.org/10.1590/pboci.2024.013

The role of chaperone-mediated autophagy in drug resistance chaperonemediated chaperone mediated
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Teixeira, Ana Beatriz da Silva

; Ramalho, Maria Carolina Clares

; Souza, Izadora de

; Andrade, Izabela Amélia Marques de

; Osawa, Isabeli Yumi Araújo

; Guedes, Camila Banca

; Oliveira, Beatriz Silva de

; Souza Filho, Cláudio Henrique Dahne de

; Silva, Tainá Lins da

; Moreno, Natália Cestari

; Latancia, Marcela Teatin

; Rocha, Clarissa Ribeiro Reily

Genetics and Molecular Biology

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2024, Volume 47 Supl. 1 elocation e20230317

Resumo: En | Texto: En | PDF: En

Abstract In the search for alternatives to overcome the challenge imposed by drug resistance development in cancer treatment, the modulation of autophagy has emerged as a promising alternative that has achieved good results in clinical trials. Nevertheless, most of these studies have overlooked a novel and selective type of autophagy: chaperone-mediated autophagy (CMA). Following its discovery, research into CMA’s contribution to tumor progression has accelerated rapidly. Therefore, we now understand that stress conditions are the primary signal responsible for modulating CMA in cancer cells. In turn, the degradation of proteins by CMA can offer important advantages for tumorigenesis, since tumor suppressor proteins are CMA targets. Such mutual interaction between the tumor microenvironment and CMA also plays a crucial part in establishing therapy resistance, making this discussion the focus of the present review. Thus, we highlight how suppression of LAMP2A can enhance the sensitivity of cancer cells to several drugs, just as downregulation of CMA activity can lead to resistance in certain cases. Given this panorama, it is important to identify selective modulators of CMA to enhance the therapeutic response. treatment trials Nevertheless chaperonemediated chaperone mediated CMA. . (CMA) discovery CMAs s rapidly Therefore turn tumorigenesis targets review Thus LAMPA LAMP A drugs cases panorama response (CMA

https://doi.org/10.1590/1678-4685-gmb-2023-0317

COVID-19 IN INFLAMMATORY BOWEL DISEASE: SHOULD WE BE MORE CAREFUL WITH THE USE OF SALICYLATES? COVID19 COVID 19 COVID-1 DISEASE SALICYLATES COVID1 1 COVID-
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MACEDO, Mariana Rolim Fernandes

; SOBREIRA, Carlos Arthur Fernandes

; LAVOR, Carola Braz de

; RÔLA, Camila Ribeiro

; ROLIM, Ticiana Maria de Lavor

; PESSOA, Francisco Sérgio Rangel de Paula

; GIRÃO, Milena Santana

; FREIRE, Caio César Furtado

; SIEBRA, Ranna Caroline Bezerra

; MELO, Isabele de Sá Silveira

; SOUZA, Marcellus Henrique Loiola Ponte de

; BRAGA, Lucia Libanez Bessa Campelo

; MELLO, Liana Perdigão

; SILVA, Débora Bezerra

; FARIAS, Luís Arthur Brasil Gadelha

; OLIVEIRA, Maura Salaroli de

; PERDIGÃO NETO, Lauro Vieira

; LEVIN, Anna Sara

Arquivos de Gastroenterologia

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2024, Volume 61 elocation e23195

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Backgrounds: Fortunately, much has been studied about COVID-19 in patients with inflammatory bowel diseases (IBD). Evidence suggests that these patients do not appear to be at increased risk of severe COVID-19. However, there are still some uncertainties regarding the clinical manifestations of COVID-19 in patients with immune-mediated diseases. Objective: This study aimed to describe the main symptoms of COVID-19 and their frequency in IBD patients and evaluate the impact of the IBD therapeutic drugs on clinical presentation of COVID-19 and to determine factors associated with COVID-19 in this population. Methods: Adult patients with IBD from three tertiary-care public, teaching hospitals in Ceará, Northeastern Brazil, were evaluated during one scheduled appointment from March to December 2020. Patients with possible or confirmed COVID-19 were compared with patients without COVID-19. Furthermore, incidences of each symptom were evaluated based on the use of IBD therapeutic drugs. Results: A total of 515 patients with IBD were included in the study: 234 with CD, and 281 with UC. Of these, 174 patients (34%) had possible/confirmed COVID-19 of whom 156 (90%) were symptomatic. Main symptoms were fever (65%) and headache (65%); gastrointestinal symptoms occurred in one third of patients and were higher than COVID-19 in general population. The factors associated with having COVID-19 were female gender (OR 1.71, 95%CI: 1.17-2.50); contact at home (OR 5.07, 95%CI: 3.31-7.78) and outside the home (OR 3.14, 95%CI: 2.10-4.71) with a case of COVID-19; work outside of the home (OR 1.87, 95%CI: 1.26-2.78); family history of COVID-19 (OR 2.29, 95%CI 1.58-3.33) use of salicylate (OR 1.71, 95%CI: 1.17-4.28); and asthma (OR 7.10, 95%CI: 1.46-34.57). Conclusion: IBD patients at high risk of COVID-19 infection may need to avoid salicylate therapy but further studies are necessary to confirm this association. Backgrounds Fortunately COVID19 COVID 19 COVID-1 IBD. . (IBD) COVID19. 19. However immunemediated immune mediated Objective population Methods tertiarycare tertiary care public Ceará Brazil 2020 Furthermore Results 51 23 CD 28 UC 17 34% 34 (34% possibleconfirmed 15 90% 90 (90% symptomatic 65% 65 (65% OR 171 1 71 1.71 95CI CI 95 1.172.50 117250 1.17 2.50 2 50 1.17-2.50) 507 5 07 5.07 3.317.78 331778 3.31 7.78 3 31 7 78 3.31-7.78 314 14 3.14 2.104.71 210471 2.10 4.71 10 4 2.10-4.71 187 87 1.87 1.262.78 126278 1.26 2.78 26 1.26-2.78) 229 29 2.29 1.583.33 158333 1.58 3.33 58 33 1.58-3.33 1.174.28 117428 4.28 1.17-4.28) 710 7.10 1.4634.57. 1463457 1.46 34.57 46 57 1.46-34.57) Conclusion association COVID1 COVID- (IBD 202 (34 9 (90 6 (65 1.7 172 1.172.5 11725 117 1.1 250 2.5 1.17-2.50 0 5.0 317 3.317.7 33177 331 3.3 778 7.7 3.31-7.7 3.1 104 2.104.7 21047 210 2.1 471 4.7 2.10-4.7 18 8 1.8 262 1.262.7 12627 126 1.2 278 2.7 1.26-2.78 22 2.2 583 1.583.3 15833 158 1.5 333 1.58-3.3 1.174.2 11742 428 4.2 1.17-4.28 7.1 4634 1.4634.57 146345 146 1.4 3457 34.5 1.46-34.57 20 (3 (9 (6 1. 1.172. 1172 11 25 2. 1.17-2.5 5. 3.317. 3317 3. 77 7. 3.31-7. 2.104. 2104 21 47 4. 2.10-4. 1.262. 1262 12 27 1.26-2.7 1.583. 1583 1.58-3. 1.174. 1174 42 1.17-4.2 463 1.4634.5 14634 345 34. 1.46-34.5 ( 1.172 1.17-2. 3.317 3.31-7 2.104 2.10-4 1.262 1.26-2. 1.583 1.58-3 1.174 1.17-4. 1.4634. 1463 1.46-34. 1.17-2 3.31- 2.10- 1.26-2 1.58- 1.17-4 1.4634 1.46-34 1.17- 1.26- 1.463 1.46-3 1.46-

RESUMO Contexto: Felizmente, muito se tem estudado sobre a COVID-19 em pacientes com doenças inflamatórias intestinais (DII). As evidências sugerem que esses pacientes não parecem ter risco aumentado de COVID-19 grave. Mas ainda se tem algumas incertezas com relação às manifestações clínicas da COVID-19 em portadores de doenças imunomediadas. Objetivo: Este estudo teve como objetivo descrever os principais sintomas da COVID-19 e sua frequência em pacientes com DII e avaliar o impacto dos medicamentos utilizados no tratamento das DII na apresentação clínica da COVID-19. Métodos: Pacientes adultos com DII de três hospitais públicos terciários de ensino do Ceará, Nordeste do Brasil, foram avaliados em consulta ambulatorial no período de março a dezembro de 2020. Pacientes com COVID-19 possível ou confirmada foram comparados com pacientes sem COVID-19. Além disso, as incidências de cada sintoma foram avaliadas com base no uso de medicamentos utilizados para tratamento da DII. Resultados: Foram incluídos no estudo 515 pacientes com DII: 234 com DC e 281 com RCU. Destes, 174 pacientes (34%) tinham COVID-19 possível/confirmado, dos quais 156 (90%) eram sintomáticos. Os principais sintomas foram febre (65%) e dor de cabeça (65%); sintomas gastrointestinais ocorreram em um terço dos pacientes, sendo mais frequentes do que na população geral com COVID-19. Os fatores associados a ter COVID-19 foram sexo feminino (OR 1,71, IC95%: 1,17-2,50); ter contato com caso de COVID-19, tanto intradomiciliar (OR 5,07; IC95%: 3,31-7,78) como fora do domicílio (OR 3,14; IC95%: 2,10-4,71); trabalhar fora de casa (OR 1,87; IC95%: 1,26-2,78); história familiar de COVID-19 (OR 2,29, IC95% 1,58-3,33), uso de salicilato (OR 1,71, IC95%: 1,17-4,28) e asma (OR 7,10; IC95%: 1,46-34,57). Conclusão: Pacientes com DII com alto risco de infecção por COVID-19 podem precisar evitar a terapia com salicilatos, mas mais estudos são necessários para confirmar esta associação. Contexto Felizmente COVID19 COVID 19 COVID-1 . (DII) grave imunomediadas Objetivo COVID19. 19. Métodos Ceará Brasil 2020 disso Resultados 51 23 28 RCU Destes 17 34% 34 (34% possívelconfirmado confirmado possível/confirmado 15 90% 90 (90% sintomáticos 65% 65 (65% OR 171 1 71 1,71 IC95 IC 1,172,50 117250 1,17 2,50 2 50 1,17-2,50) COVID19, 19, 5,07 507 5 07 3,317,78 331778 3,31 7,78 3 31 7 78 3,31-7,78 3,14 314 14 2,104,71 210471 2,10 4,71 10 4 2,10-4,71) 1,87 187 87 1,262,78 126278 1,26 2,78 26 1,26-2,78) 229 29 2,29 1,583,33, 158333 1,58 3,33 , 58 33 1,58-3,33) 1,174,28 117428 4,28 1,17-4,28 7,10 710 1,4634,57. 1463457 1,46 34,57 46 57 1,46-34,57) Conclusão salicilatos associação COVID1 COVID- (DII 202 (34 9 (90 6 (65 1,7 IC9 172 1,172,5 11725 117 1,1 250 2,5 1,17-2,50 5,0 0 317 3,317,7 33177 331 3,3 778 7,7 3,31-7,7 3,1 104 2,104,7 21047 210 2,1 471 4,7 2,10-4,71 1,8 18 8 262 1,262,7 12627 126 1,2 278 2,7 1,26-2,78 22 2,2 583 1,583,33 15833 158 1,5 333 1,58-3,33 1,174,2 11742 428 4,2 1,17-4,2 7,1 4634 1,4634,57 146345 146 1,4 3457 34,5 1,46-34,57 20 (3 (9 (6 1, 1,172, 1172 11 25 2, 1,17-2,5 5, 3,317, 3317 3, 77 7, 3,31-7, 2,104, 2104 21 47 4, 2,10-4,7 1,262, 1262 12 27 1,26-2,7 1,583,3 1583 1,58-3,3 1,174, 1174 42 1,17-4, 463 1,4634,5 14634 345 34, 1,46-34,5 ( 1,172 1,17-2, 3,317 3,31-7 2,104 2,10-4, 1,262 1,26-2, 1,583, 1,58-3, 1,174 1,17-4 1,4634, 1463 1,46-34, 1,17-2 3,31- 2,10-4 1,26-2 1,583 1,58-3 1,17- 1,4634 1,46-34 2,10- 1,26- 1,58- 1,463 1,46-3 1,46-

https://doi.org/10.1590/s0004-2803.24612023-155

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila

; Rêgo, Jozelia

; Machado, Ketty Lysie Libardi Lira

; Miyamoto, Samira Tatiyama

; Burian, Ana Paula Neves

; Dias, Laiza Hombre

; Pretti, Flavia Zon

; Batista, Danielle Cristina Filgueira Alves

; Mill, José Geraldo

; Oliveira, Yasmin Gurtler Pinheiro de

; Gadelha, Carolina Strauss Estevez

; Gouveia, Maria da Penha Gomes

; Moulin, Anna Carolina Simões

; Souza, Bárbara Oliveira

; Aguiar, Laura Gonçalves Rodrigues

; Vieira, Gabriel Smith Sobral

; Grillo, Luiza Lorenzoni

; Lima, Marina Deorce de

; Pasti, Laís Pizzol

; Surlo, Heitor Filipe

; Faé, Filipe

; Moulaz, Isac Ribeiro

; Macabú, Mariana de Oliveira

; Ribeiro, Priscila Dias Cardoso

; Magalhães, Vanessa de Oliveira

; Aguiar, Mariana Freitas de

; Biegelmeyer, Erika

; Peixoto;, Flávia Maria Matos Melo Campos

; Kayser, Cristiane

; Souza, Alexandre Wagner Silva de

; Castro, Charlles Heldan de Moura

; Ribeiro, Sandra Lúcia Euzébio

; Telles, Camila Maria Paiva França

; Bühring, Juliana

; Lima, Raquel Lima de

; Santos, Sérgio Henrique Oliveira Dos

; Dias, Samuel Elias Basualto

; Melo, Natália Seixas de

; Sanches, Rosely Holanda da Silva

; Boechat, Antonio Luiz

; Sartori, Natália Sarzi

; Hax, Vanessa

; Dória, Lucas Denardi

; Rezende, Rodrigo Poubel Vieira de

; Baptista, Katia Lino

; Fortes, Natália Rodrigues Querido

; Melo, Ana Karla Guedes de

; Melo, Tâmara Santos

; Vieira, Rejane Maria Rodrigues de Abreu

; Vieira, Adah Sophia Rodrigues

; Kakehasi, Adriana Maria

; Tavares, Anna Carolina Faria Moreira Gomes

; Landa, Aline Teixeira de

; Costa, Pollyana Vitoria Thomaz da

; Azevedo, Valderilio Feijó

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Pinheiro, Marcelo de Medeiros

; Monticielo, Odirlei André

; Reis-neto, Edgard Torres Dos

; Ferreira, Gilda Aparecida

; Souza, Viviane Angelina de

; Teixeira-Carvalho, Andréa

; Xavier, Ricardo Machado

; Sato, Emilia Inoue

; Valim, Valeria

; Pileggi, Gecilmara Salviato

; Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Resumo: En | Texto: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

O Papel da Revista Diálogos no Processo de Formação Continuada e Inovação no Exercício da Psicologia no Brasil
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Silva, Iolete Ribeiro da

; Bastos, Antonio Virgílio Bittencourt

; Silva, Camila Ribeiro da

Psicologia: Ciência e Profissão

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2024, Volume 44 Nº spe1 elocation e287526

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O sistema Conselhos de Psicologia cumpre a função institucional de fiscalizar e orientar o exercício da profissional de psicologia no Brasil. A função de orientação envolve necessariamente políticas e ações que disponibilizem para a categoria o acesso aos avanços do conhecimento científico e das formas de intervenção, compartilhando experiências exitosas que contribuam para o aprendizado coletivo. A revista Diálogos cumpre essa função ao se dirigir primordialmente para o público que atua na prestação de serviços à população nos mais diferentes contextos. Este artigo recupera a trajetória desse veículo de divulgação ao longo dos seus 19 anos de existência, destacando temáticas que foram objeto de discussão e análises nos seus diversos números. Os resultados revelam o quanto a revista tem sido um instrumento importante na construção de um modelo de atuação profissional ético, cientificamente embasado e socialmente comprometido, concretizando diretrizes políticas do sistema de conselho referendadas pela categoria nesse período. Resumo Brasil intervenção coletivo contextos 1 existência números ético comprometido período

Abstract: The Psychology Councils system fulfills the institutional function of supervising and guiding the professional practice of psychology in Brazil. Its guidance must involve policies and actions that offer the category access to advances in scientific knowledge and intervention methods, sharing successful experiences that contribute to collective learning. The Diálogos journal fulfills this role by primarily addressing the public involved in providing services to populations in various contexts. This study traces the trajectory of this dissemination vehicle over its 19 years of existence, highlighting topics that underwent discussion and analysis in its various issues. Results show the extent to which the journal has been an important tool in constructing an ethical, scientifically based, and socially committed professional performance model, materializing the political guidelines of the council system the category endorsed in the evaluated period. Abstract Brazil methods learning contexts 1 existence issues ethical based model period

Resumen: El sistema de Consejos de Psicología cumple la función institucional de fiscalizar y orientar el ejercicio profesional de la Psicología en Brasil. La función de orientación implica necesariamente políticas y acciones que proporcionen a la categoría el acceso a los avances del conocimiento científico y a las formas de intervención, compartiendo experiencias exitosas que contribuyan al aprendizaje colectivo. La Revista Diálogos cumple esta función y se dirige primordialmente al público que trabaja con la prestación de servicios a la población en los más diversos contextos. Este artículo recupera la trayectoria de este vehículo de divulgación a lo largo de sus 19 años de existencia, destacando temáticas que fueron objeto de discusión y análisis en sus diversos números. Los resultados revelan que la revista ha sido una herramienta importante en la construcción de un modelo de actuación profesional ético, científicamente fundamentado y socialmente comprometido, lo cual concretó directrices políticas del sistema de consejo refrendadas por la categoría en este período. Resumen Brasil intervención colectivo contextos 1 existencia números ético comprometido período

https://doi.org/10.1590/1982-3703003287526

VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation): protocol for a multicenter randomized open-label trial of watchful waiting versus antimicrobial therapy for ventilator-associated tracheobronchitis VentilatorAssociated Ventilator Associated Evaluation Evaluation) openlabel open label ventilatorassociated ventilator associated
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Tomazini, Bruno Martins

; Besen, Bruno Adler Maccagnan Pinheiro

; Dietrich, Camila

; Gandara, Ana Paula Rossi

; Silva, Debora Patrícia

; Pinheiro, Carla Cristina Gomes

; Luz, Mariane Nascimento

; Mattos, Renata Rodrigues de

; Reis, Luiz Fernando Lima

; Roepke, Roberta Muriel Longo

; Duarte, Carlos Sérgio Luna Gomes

; Nassar Júnior, Antônio Paulo

; Veiga, Viviane Cordeiro

; Arns, Beatriz

; Nascimento, Giovanna Marssola

; Pereira, Adriano José

; Cavalcanti, Alexandre Biasi

; Machado, Flávia Ribeiro

; Azevedo, Luciano Cesar Pontes

Critical Care Science

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2024, Volume 36 elocation e20240029en

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Background Ventilator-associated tracheobronchitis is a common condition among invasively ventilated patients in intensive care units, for which the best treatment strategy is currently unknown. We designed the VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) trial to assess whether a watchful waiting antibiotic treatment strategy is noninferior to routine antibiotic treatment for ventilator-associated tracheobronchitis regarding days free of mechanical ventilation. Methods VATICAN is a randomized, controlled, open-label, multicenter noninferiority trial. Patients with suspected ventilator-associated tracheobronchitis without evidence of ventilator-associated pneumonia or hemodynamic instability due to probable infection will be assigned to either a watchful waiting strategy, without antimicrobial administration for ventilator-associated tracheobronchitis and prescription of antimicrobials only in cases of ventilator-associated pneumonia, sepsis or septic shock, or another infectious diagnosis, or to a routine antimicrobial treatment strategy for seven days. The primary outcome will be mechanical ventilation-free days at 28 days, and a key secondary outcome will be ventilator-associated pneumonia-free survival. Through an intention-to-treat framework with a per-protocol sensitivity analysis, the primary outcome analysis will address noninferiority with a 20% margin, which translates to a 1.5 difference in ventilator-free days. Other analyses will follow a superiority analysis framework. Conclusion The VATICAN trial will follow all national and international ethical standards. We aim to publish the trial in a high-visibility general journal and present it at critical care and infectious disease conferences for dissemination. These results will likely be immediately applicable to the bedside upon trial completion and will provide information with a low risk of bias for guideline development. Ventilatorassociated Ventilator associated units unknown VentilatorAssociated Associated Evaluation ventilatorassociated ventilator ventilation randomized controlled openlabel, openlabel open label, label open-label shock diagnosis ventilationfree 2 pneumoniafree survival intentiontotreat intention treat perprotocol per protocol 20 margin 15 1 5 1. ventilatorfree standards highvisibility high visibility dissemination development

RESUMO Contexto A traqueobronquite associada ao ventilador é uma condição comum entre pacientes ventilados invasivamente em unidades de terapia intensiva, para a qual se desconhece atualmente a melhor estratégia de tratamento. Desenhamos o estudo VATICAN (Ventilator-Associated Tracheobronchitis Initiative to Conduct Antibiotic Evaluation) para avaliar se uma estratégia de tratamento antibiótico de espera vigilante não é inferior ao tratamento antibiótico de rotina para traqueobronquite associada ao ventilador em relação aos dias sem ventilador mecânico. Métodos O VATICAN é um estudo randomizado, controlado, aberto e multicêntrico de não inferioridade. Os pacientes com suspeita de traqueobronquite associada ao ventilador sem evidência de pneumonia associada ao ventilador ou instabilidade hemodinâmica devido a uma provável infecção serão designados para uma estratégia de espera vigilante, sem administração profilática de antimicrobianos contra traqueobronquite associada ao ventilador e prescrição de antimicrobianos somente em casos de pneumonia associada ao ventilador, sepse ou choque séptico, ou outro diagnóstico infeccioso, ou para uma estratégia de tratamento antimicrobiano de rotina por 7 dias. O desfecho primário será o número de dias sem ventilador mecânico em 28 dias, e um desfecho secundário importante será a sobrevida sem pneumonia associada ao ventilador. Por meio de uma estrutura de intenção de tratar com análise de sensibilidade por protocolo, a análise do desfecho primário abordará a não inferioridade com margem de 20%, o que se traduz em uma diferença de 1,5 dia sem ventilador. Outras análises seguirão uma estrutura de análise de superioridade. Conclusão O VATICAN seguirá todos os padrões éticos nacionais e internacionais. O objetivo é publicar o estudo em um periódico geral de alta visibilidade e apresentá-lo em conferências de cuidados intensivos e doenças infecciosas para divulgação. Estes resultados provavelmente serão imediatamente aplicáveis à beira do leito após a conclusão do estudo e fornecerão informações com baixo risco de viés para o desenvolvimento de diretrizes. intensiva VentilatorAssociated Ventilator Associated Evaluation randomizado controlado séptico infeccioso 2 protocolo 20 20% 15 1 5 1, superioridade internacionais apresentálo apresentá lo divulgação diretrizes

https://doi.org/10.62675/2965-2774.20240029-en

The occurrence of enterobacteria and the rate of resistance to antimicrobials in illegally trafficked Sporophila passerines
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Teixeira, Régis Siqueira de Castro

; Paschoal Filho, Neilton Monteiro

; Marques, Adson Ribeiro

; Lima, Bruno Pessoa

; Melo, Lucas Silva

; Freitas, Cibelle Mara Pereira de

; Fontão, Camila Carvalho

; Lopes, Elisângela de Souza

; Beleza, Antonio Jackson Forte

; Silva, Isaac Neto Goes da

; Ribeiro, Carlos Diego de Sousa

; Maciel, William Cardoso

Ciência Animal Brasileira

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2024, Volume 25 elocation 78490E

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo desta pesquisa foi investigar a ocorrência de enterobactérias em passeriformes do gênero Sporophila, provenientes do tráfico ilegal de animais, e analisar sua resistência antimicrobiana. Um total de 35 aves, aparentemente saudáveis e provenientes de criações ilegais, foram encaminhadas ao Laboratório de Estudos Ornitológicos da Universidade Estadual do Ceará (Fortaleza, Ceará, Brasil) por órgãos ambientais. Amostras obtidas a partir de suabes cloacais foram coletadas de cada ave e submetidas a processamento microbiológico tradicional, utilizando técnicas padrão de cultivo e identificação bacteriana. O teste de sensibilidade aos antimicrobianos foi avaliado pelo método de disco de difusão. Das amostras examinadas, 23 (65,7%) apresentaram a presença de enterobactérias, sendo Escherichia coli (28,6%) e Serratia liquefaciens (25,7%) as mais frequentes. A resistência antimicrobiana referente aos isolados totais foi observada com mais frequência em relação à ciprofloxacina (28,1%), seguida por tetraciclina (25,0%) e enrofloxacina (18,8%). Especificamente em relação à Serratia liquefaciens, a taxa de resistência foi a mais altas, atingindo 66,6% dos isolados. Com base nos resultados obtidos, podemos concluir que as amostras cloacais das aves apresentaram isolamento de diversos membros da ordem Enterobacteriales, sendo E. coli e S. liquefaciens as mais frequentes. Também foi observada a ocorrência de resistência antimicrobiana a diversos fármacos utilizados, assim como casos de multiresistência, o que mostra que esse problema está presente em pássaros silvestres oriundo de manutenções ilegais. Isso ressalta a necessidade de considerar a presença de bactérias resistentes a antimicrobianos em programas de soltura, visando evitar a dispersão desses microrganismos no meio ambiente. Sporophila animais 3 ilegais Fortaleza, Fortaleza (Fortaleza Brasil ambientais tradicional bacteriana difusão examinadas 2 65,7% 657 65 7 (65,7% 28,6% 286 28 6 (28,6% 25,7% 257 25 (25,7% frequentes 28,1%, 281 28,1% , 1 (28,1%) 25,0% 250 0 (25,0% 18,8%. 188 18,8% . 18 8 (18,8%) altas 666 66 66,6 obtidos Enterobacteriales E S utilizados multiresistência soltura ambiente 65,7 (65,7 28,6 (28,6 25,7 (25,7 28,1 (28,1% 25,0 (25,0 18,8 (18,8% 66, 65, (65, 28, (28, 25, (25, (28,1 18, (18,8 (65 (28 (25 (18, (6 (2 (18 ( (1

Abstract We investigate the occurrence of enterobacteria and antimicrobial resistance in passerines of the genus Sporophila seized from illegal trafficking. A total of 35 birds, apparently healthy and from illegal breeding, were sent to the Laboratory of Ornithological Studies at the State University of Ceará (Fortaleza, Ceará, Brazil) by environmental agencies. Cloacal swabs were collected from each bird and subjected to traditional microbiological processing, using standard cultivation and bacterialidentification techniques. We conducted antimicrobial susceptibility testing using the disc-diffusion method. Twenty-three birds (65.7%) exhibited enterobacteria, with Escherichia coli (28.6%) and Serratia liquefaciens (25.7%) being the most common. Antimicrobial resistance in total isolates was observed most frequently in relation to ciprofloxacin (28.1%), followed by tetracycline (25.0%) and enrofloxacin (18.8%). The rate of resistance to Serratia liquefaciens was the highest (i.e., 66.6% of isolates). The birds’ cloacal samples revealed several members of the Enterobacterales order, with E. coli and S. liquefaciens being the most prevalent. We also observed antimicrobial resistance to several drugs, as well as cases of multi-resistance. Antimicrobial resistance is clearly present in wild birds resulting from illegal keeping. These findings highlight the importance of considering antimicrobial-resistant bacteria in release programs to prevent these microorganisms from dispersing into the environment. trafficking 3 breeding Fortaleza, Fortaleza (Fortaleza Brazil agencies processing techniques discdiffusion disc diffusion method Twentythree Twenty three 65.7% 657 65 7 (65.7% 28.6% 286 28 6 (28.6% 25.7% 257 25 (25.7% common 28.1%, 281 28.1% , 1 (28.1%) 25.0% 250 0 (25.0% 18.8%. 188 18.8% . 18 8 (18.8%) i.e., ie i e (i.e. 666 66 66.6 isolates. isolates) order E S prevalent drugs multiresistance. multiresistance multi resistance. multi-resistance keeping antimicrobialresistant resistant environment 65.7 (65.7 28.6 2 (28.6 25.7 (25.7 28.1 (28.1% 25.0 (25.0 18.8 (18.8% i.e. (i.e 66. 65. (65. 28. (28. 25. (25. (28.1 18. (18.8 i.e (65 (28 (25 (18. (6 (2 (18 ( (1

https://doi.org/10.1590/1809-6891v25e-78490e

Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida

; Silva, Pedro Victor de Castro

; Ferreira, João Henrique Fregadolli

; Marques, Alexandre Coelho

; Toso, Fabio Fieni

; Vasconcelos, Claudia Cristina Ferreira

; Brum, Doralina Guimarães

; Pereira, Samira Luisa dos Apóstolos

; Adoni, Tarso

; Rocha, Leticia Januzi de Almeida

; Sampaio, Leticia Pereira de Brito

; Sousa, Nise Alessandra de Carvalho

; Paolilo, Renata Barbosa

; Pizzol, Angélica Dal

; Costa, Bruna Klein da

; Disserol, Caio César Diniz

; Pupe, Camila

; Valle, Daniel Almeida do

; Diniz, Denise Sisterolli

; Abrantes, Fabiano Ferreira de

; Schmidt, Felipe da Rocha

; Cendes, Fernando

; Oliveira, Francisco Tomaz Meneses de

; Martins, Gabriela Joca

; Silva, Guilherme Diogo

; Lin, Katia

; Pinto, Lécio Figueira

; Santos, Mara Lúcia Schimtz Ferreira

; Gonçalves, Marcus Vinícius Magno

; Krueger, Mariana Braatz

; Haziot, Michel Elyas Jung

; Barsottini, Orlando Graziani Povoas

; Nascimento, Osvaldo José Moreira do

; Nóbrega, Paulo Ribeiro

; Proveti, Priscilla Mara

; Castilhos, Raphael Machado do

; Daccach, Vanessa

; Glehn, Felipe von

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 Nº 7 elocation s00441788586

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE

Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE

https://doi.org/10.1055/s-0044-1788586

10.

Impact of COVID-19 on pediatric dental care in two epicenters: Italy and Brazil COVID19 COVID 19 COVID-1 epicenters COVID1 1 COVID-
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BECKMAN, Camilla Karoline de Carvalho

; LUPPIERI, Valentina

; PEREIRA, Letícia Martins

; SILVA, Camila Ribeiro

; CASTELO, Paula Midori

; CADENARO, Milena

; RONTANI, Regina Maria Puppin

; CASTILHO, Aline Rogéria Freire de

Brazilian Oral Research

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2024, Volume 38 elocation e068

Resumo: En | Texto: En | PDF: En

Abstract The study aimed to compare the adherence of Brazilian and Italian pediatric dentists to the biosafety measures and operative protocols recommended by the health authorities during COVID-19 pandemic and to classify the participants according to their risk of infection. An online questionnaire with 34 questions about sociodemographic and occupational data, dental practice organization, biological risk management, and clinical operative protocols was sent to Brazilian and Italian pediatric dentists using a convenience sampling strategy. Chi-square test and multivariate analysis (two-step cluster) were performed (α = 5%). Of 641 respondents (377 Brazilians and 264 Italians), most were female (94% and 70%, respectively), aged 20-39 years (63%), with over 10 years of professional experience (58% and 49%, respectively). Based on adherence to recommended biosafety measures, participants were classified as “safer” (n = 219) or “less safe” (n = 422). Adherence to recommended protocols by the majority of participants resulted in low contagion rates (Brazilians = 5%; Italians = 12.5%). Participants with extensive professional experience in the dental setting exhibited a greater tendency to implement multiple adaptations (three or more) in their practice. Most participants (Brazilians = 92%; Italians = 80.7%) adopted the recommended minimal intervention dentistry approaches, with the use of fissure sealants and the use of non-rotary instruments for caries removal the most frequently techniques used among Brazilians (36%) and Italians (66%), respectively. Two different profiles of pediatric dentists were identified based on the biosafety protocols adopted during the pandemic. In addition, changes were implemented in the dental care provided to children, with focus on the minimal intervention dentistry. COVID19 COVID 19 COVID-1 infection 3 data organization management strategy Chisquare Chi square twostep two step cluster α 5%. 5 5% . 5%) 64 377 (37 26 Italians, , Italians) 94% 94 (94 70 70% respectively, respectively respectively) 2039 20 39 20-3 63%, 63 63% (63%) 1 58% 58 (58 49 49% safer “safer n 219 less safe 422. 422 422) 12.5%. 125 12.5% 12 12.5%) three more 92% 92 80.7% 807 80 7 approaches nonrotary non rotary 36% 36 (36% 66%, 66 66% (66%) addition children COVID1 COVID- 6 37 (3 2 9 (9 203 20- (63% (5 4 21 42 12.5 80.7 8 (36 (66% ( (63 12. 80. (66 (6

https://doi.org/10.1590/1807-3107bor-2024.vol38.0068

11.

Trajetórias turbinadas no ensino superior: aprimoramento cognitivo e desempenho acadêmico de estudantes de Medicina superior
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Silva, Camila Ribeiro da

; Silva, Iolete Ribeiro da

; Neves, André Luiz Machado das

Revista Brasileira de Educação Médica

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2024, Volume 48 Nº 4 elocation e122

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: The demand for performance, the cult of performance, technicality, among others, are derived from capitalist productivism and its logic. The pursuit of performance, the cult of achievement, technicism, among others, stem from productivity and its logics. Individuals in the academic environment are immersed in these processes marked by this derivation. Consequently, non-therapeutic, pharmacological or non-pharmacological interventions on brain function emerge, enhancing cognitive functions/skills/capacities to a level beyond average functioning. Objective: To assess the use of cognitive enhancement strategies among medical students and evaluate their effects on mental health and academic performance, identifying potential interventions to optimize student well-being and the educational process. Method: This is a qualitative field research. Semi-structured interviews were conducted with medical students to gather data, which were analyzed using the constructive-interpretation method. Result: The data revealed that university students seek adaptive strategies to maintain productivity in academia, even if they have to face unforeseeable consequences of these mechanisms. Seeking alternatives to remain productive is linked to the students’ self-esteem, also affecting their relationships with fellow students and faculty members. Conclusion: It is revealed that medical students resort to cognitive enhancement strategies, such as consuming energy drinks and caffeine, to cope with rigorous academic demands. Although these practices may initially appear beneficial, as they enhance performance and productivity, they are intrinsically linked to significant adverse effects on the students’ mental health, including increased stress, anxiety, and dependency. Introduction technicality others logic achievement technicism logics derivation Consequently nontherapeutic, nontherapeutic non therapeutic, therapeutic non-therapeutic nonpharmacological emerge functionsskillscapacities functions skills capacities functioning Objective wellbeing well being process Method research Semistructured Semi structured constructiveinterpretation constructive interpretation method Result academia mechanisms selfesteem, selfesteem self esteem, esteem self-esteem members Conclusion caffeine demands beneficial stress anxiety dependency

RESUMO Introdução: A cobrança de desempenho, o culto à performance, o tecnicismo, entre outras, são derivadas do produtivismo capitalista e suas lógicas. As pessoas que integram o ambiente acadêmico estão imersas nesses processos marcados por essa derivação. Dessa forma, surgem intervenções não terapêuticas, farmacológicas ou não, sobre o funcionamento cerebral, ampliando a performance de funções/habilidades/capacidades cognitivas a um nível mais elevado para além da média de funcionamento. Objetivo: Este estudo teve como objetivos examinar o uso de estratégias de aprimoramento cognitivo entre estudantes de Medicina e avaliar seus efeitos na saúde mental e no desempenho acadêmico, de modo a identificar intervenções potenciais para otimizar o bem-estar estudantil e o processo educativo. Método: Trata-se de uma pesquisa de campo, de abordagem qualitativa. Para o levantamento de dados, foram efetuadas entrevistas semiestruturadas com estudantes do curso de Medicina. Para a análise dos dados, empreendeu-se a técnica da análise construtivo-interpretativa. Resultado: Os dados mostraram que os estudantes universitários buscam estratégias adaptativas para se manterem produtivos na universidade, mesmo que precisem enfrentar consequências, nem sempre previsíveis, desses mecanismos. Buscar alternativas para se manterem produtivos está vinculado à autoestima do estudante, o que impacta também a sua relação com os outros estudantes e com os seus docentes. Conclusão: Revela-se que estudantes de Medicina recorrem a estratégias de aprimoramento cognitivo, como o consumo de energéticos e cafeína, para que possam enfrentar as rigorosas demandas acadêmicas. Embora tais práticas possam inicialmente parecer benéficas ao incrementarem o desempenho e a produtividade, elas estão intrinsecamente ligadas a efeitos adversos significativos sobre a saúde mental dos alunos, incluindo aumento do estresse, ansiedade e dependência. Introdução tecnicismo outras lógicas derivação forma terapêuticas cerebral funçõeshabilidadescapacidades funções habilidades capacidades Objetivo bemestar bem estar educativo Método Tratase Trata campo qualitativa empreendeuse empreendeu construtivointerpretativa. construtivointerpretativa construtivo interpretativa. interpretativa construtivo-interpretativa Resultado universidade consequências previsíveis mecanismos estudante docentes Conclusão Revelase Revela cafeína acadêmicas produtividade alunos estresse dependência

https://doi.org/10.1590/1981-5271v48.4-2023-0229

12.

Participação social e Atenção Primária em Saúde no Brasil: uma revisão de escopo
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Buziquia, Sabrina Pontes

; Junges, José Roque

; Lopes, Priscila Pereira da Silva

; Nied, Camila

; Gonçalves, Tonantzin Ribeiro

Saúde e Sociedade

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2023, Volume 32 Nº 1 elocation e220121pt

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O presente artigo objetiva realizar uma revisão de escopo da literatura, com o intuito de compreender as experiências formais de participação social que tem sido desenvolvidas no contexto da Atenção Primária em Saúde (APS) no Brasil, desde a criação do Sistema Único de Saúde (SUS) até novembro de 2020. Foram realizadas pesquisas nas bases Lilacs, PubMed, PsycINFO e Sociological Abstracts, sendo achados 20 artigos abordando a participação social e a APS. Os resultados encontrados foram discutidos no que se refere ao perfil dos participantes e à competência para participar, ao processo de participar e à construção de ações participativas, além da centralidade da educação permanente como forma de fortalecer a participação social em saúde. A pesquisa revelou distintas experiências de participação social desenvolvidas nos territórios onde atua a APS, destacando-se as dificuldades enfrentadas no processo de implementação dos Conselhos Locais de Saúde (CLS). Sendo assim, discute-se que o fortalecimento da APS, principalmente do modelo Estratégia Saúde da Família (ESF), envolve, de modo dialético, a construção e qualificação dos espaços participativos, o que resultaria em uma estratégia central de defesa do SUS em um momento de recrudescimento das relações democráticas no país.

Abstract This article aimed to carry out a scoping review of the literature to understand the formal experiences of social participation that have been developed in the context of the Brazilian Primary Health Care (PHC), since the creation of the Brazilian National Health System (SUS) until November 2020. The databases LILACS, PubMed, PsycINFO, and Sociological Abstracts were searched, and 20 articles were included that described the social participation in the context of PHC. The results found were discussed regarding the profile of the participants and the competence to participate, the process of participation and the building of participatory actions, and the centrality of permanent education as a way to strengthen social participation in health. The research revealed distinct experiences of social participation developed in the territories where the PHC operates, highlighting the difficulties faced in the process of implementing the Local Health Councils (LHC). Thus, it is understood that strengthening the PHC, especially the Family Health Strategy (FHS) model, involves, in a dialectical way, the construction and the qualification of participatory spaces, which would result in a central strategy to defend the SUS at this time of resurgence of democratic relations in Brazil.

https://doi.org/10.1590/s0104-12902023220121pt

13.

Participação social e Atenção Primária em Saúde no Brasil: uma revisão de escopo Brasil
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Buziquia, Sabrina Pontes

; Junges, José Roque

; Lopes, Priscila Pereira da Silva

; Nied, Camila

; Gonçalves, Tonantzin Ribeiro

Saúde e Sociedade

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2023, Volume 32 Nº 1 elocation e220121pt

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/s0104-12902023220121pt

14.

Impact of high-fat diet consumption during prolonged period of pregnancy on placenta structures and umbilical vascular growth in goats highfat high fat
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Bezerra, Alessandra Façanha

; Alves, Juliana Paula Martins

; Fernandes, César Carneiro Linhares

; Cavalcanti, Camila Muniz

; Silva, Maria Raquel Lopes

; Conde, Alfredo José Herrera

; Palomino, Gaby Judith Quispe

; Teixeira, Dárcio Ítalo Alves

; Rego, Aníbal Coutinho do

; Rodrigues, Ana Paula Ribeiro

; Rondina, Davide

Animal Reproduction

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2023, Volume 20 Nº 2 elocation e20230019

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to verify the impact of high-fat diet consumption for a prolonged period on oxidative stress, fetal growth, umbilical vascular system, and placental structures in pregnant goats. Twenty-two pregnant goats were grouped into the control diet (n= 11) and fat diet (n = 11). Flaxseed meal was added to the fat diet, replacing the corn grain of concentrate, from gestational day 100 to delivery date. Diets were isonitrogenous and isoenergetic, differing in fat content (2.8% vs. 6.3% dry matter). The fat group showed higher feed intake and total plasma lipid levels than the control group (P < 0.001). No difference was found in placentome, and umbilical vascular development. Fat diet-fed goats exhibited a lower systolic peak in the umbilical artery. At delivery, placental traits were similar with the exception of the cotyledon width (P = 0.0075), which was smaller in the fat group and cotyledon surface (P = 0.0047) for multiple pregnancy of fat diet. Cotyledonary epithelium showed more intense staining of lipid droplets and a greater area for lipofuscin staining in the fat group compared to control group (P < 0.001). The mean live weight of the kids was lower in the fat group in the first week after delivery than in control group. Thus, in goats, the continuous administration of a high-fat diet during pregnancy does not appear to modify the fetal-maternal vascular structures but has an impact on a part of the placental structure; therefore, its use must be carefully evaluated. highfat high stress growth system Twentytwo Twenty two n= n 11 11. . concentrate 10 date isoenergetic 2.8% 28 2 8 (2.8 vs 63 6 3 6.3 matter. matter matter) P 0.001. 0001 0.001 0 001 0.001) placentome development dietfed fed artery 0.0075, 00075 0.0075 , 0075 0.0075) 0.0047 00047 0047 Thus fetalmaternal maternal structure therefore evaluated 1 2.8 (2. 6. 000 0.00 00 0007 0.007 007 0.004 0004 004 2. (2 0.0 ( 0.

https://doi.org/10.1590/1984-3143-ar2023-0019

15.

Evaluation of the effect of physical exercise interventions in Primary Health Care in Brazil on cardiometabolic risk factors: a systematic review factors
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Brunheroti, Karina de Almeida

; Brito, Bruna Thais Gomes de

; Silva, Ana Flávia Andalécio Couto da

; Castro, Gabriela Lima de

; Viana, Rebeca Baptista Fonseca

; Barbosa, Luis Fabiano

; Puga, Guilherme Morais

; Andaki, Alynne Christian Ribeiro

; Papini, Camila Bosquiero

Revista Brasileira de Cineantropometria & Desempenho Humano

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2023, Volume 25 elocation e86876

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The objective was to systematically search and synthesize the evidence available in the literature about the effect of physical exercise interventions Primary Health Care (PHC), carried out in Brazil, on cardiometabolic risk factors. The search was performed in the PubMed, Virtual Health Library and Web of Science databases. The inclusion criteria were: studies with physical activity (PA) interventions or exercise in PHC; carried out in Brazil; population aged >18 years; at least one cardiometabolic risk factor assessed pre and post-intervention. The “Health Sciences Descriptors” were used to define the search descriptors: “physical activity” OR “exercise” OR “motor activity” AND “primary health care” OR “health centers” OR “primary care” AND “Brazil”. The selection phases were performed by pairs of blinded researchers and the conflicts were decided by a third evaluator. Jadad scale was used to assess the methodological quality of the articles included. In total, 1,817 articles were found and 26 duplicates excluded, leaving 1,791 for reading of titles. The abstracts of 105 articles were read, and 53 articles were read in full. Finally, 06 articles were considered eligible and included in the review. The cardiometabolic risk factors evaluated in the included studies were body mass index (4 studies), waist-hip ratio (1 study), fat percentage (1 study), blood pressure (2 studies), lipid profile (1 study), inflammatory profile (1 study), and aerobic capacity (3 studies). It is concluded that there is insufficient evidence in the literature about the effect of exercise interventions in PHC with a focus on cardiometabolic risk factors. PHC, , (PHC) Brazil PubMed databases PA (PA 18 >1 years postintervention. postintervention post intervention. intervention post-intervention Descriptors descriptors “exercise motor primary care centers Brazil. . “Brazil” evaluator total 1817 1 817 1,81 2 excluded 1791 791 1,79 titles 10 5 full Finally 0 review 4 ( studies, studies) waisthip waist hip study, study study) 3 studies. (PHC > “Brazil 181 81 1,8 179 79 1,7 8 1, 17 7

Resumo O objetivo foi buscar sistematicamente e sintetizar as evidências disponíveis na literatura acerca do efeito de intervenções com exercício físico na Atenção Primária à Saúde (APS), realizadas no Brasil, sobre os fatores de risco cardiometabólicos. A busca sistemática foi realizada nas bases de dados PubMed, Biblioteca Virtual em Saúde e Web of Science. Foram incluídos estudos com intervenção de AF ou exercício na APS; realizadas no Brasil; com população >18 anos de idade; pelo menos um fator de risco cardiometabólico avaliado pré e pós intervenção. Utilizou-se o Descritores em Ciências da Saúde para definir os descritores de busca: “physical activity” OR “exercise” OR “motor activity” AND “primary health care” OR “health centers” OR “primary care” AND “Brazil”. As fases de seleção foram realizadas por pares e com cegamento e os conflitos decididos por um terceiro avaliador. Utilizou-se a escala de Jadad para avaliar a qualidade metodológica dos artigos incluídos. Foram encontrados 1.817 artigos e excluídas 26 duplicatas, restando 1.791 para leitura dos títulos. Foram lidos 105 resumos e 53 artigos na íntegra. Por fim, 06 artigos foram considerados elegíveis e incluídos na revisão. Os fatores de risco cardiometabólicos avaliados nos estudos incluídos foram índice de massa corporal (4 estudos), razão cintura quadril (1 estudo), percentual de gordura (1 estudo), pressão arterial (2 estudos), perfil lipídico (1 estudo), perfil inflamatório (1 estudo) e capacidade aeróbica (3 estudos). Conclui-se que não há evidências suficientes na literatura sobre o efeito das intervenções de exercícios na APS com foco nos fatores de risco cardiometabólicos. APS, , (APS) Brasil PubMed Science 18 >1 idade Utilizouse Utilizou se physical activity exercise “exercise motor primary care centers Brazil. Brazil . “Brazil” avaliador 1817 1 817 1.81 2 duplicatas 1791 791 1.79 títulos 10 5 íntegra fim 0 revisão 4 ( estudos, estudos) estudo, estudo 3 estudos. Concluise Conclui (APS > “Brazil 181 81 1.8 179 79 1.7 8 1. 17 7

https://doi.org/10.1590/1980-0037.2023v25e86876

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