Abstract In the last few years, the presence of geosmin (GEO) in water bodies has caused serious problems related to water consumption by the population. Many studies focus on its occurrence and detection, but little is discussed about the technologies for treatment and removal of this contaminant. In this way, the present work aims to present a bibliographic search and a bibliometric analysis carried out in the Web of Science database and in VOSviewer software about geosmin remediation, in the last 10 years. 100 articles were found, of which only one, from 2021, was a review. It was possible to assess that the subject has gained greater notoriety in the last 7 years, since the year 2016 marked the increase of publications on the subject, as well as an increasing number of citations. Among the most published countries is the People’s Republic of China, with 53% of publications. Bibliometric analysis showed that GEO is directly related to 2-methylisoborneol (2-MIB), since both occur simultaneously in water bodies. In addition, it was possible to identify that adsorptive processes are the most used in the removal of these contaminants, followed by advanced oxidative processes and biological processes, in that order. years (GEO population detection contaminant way remediation 1 found one 2021 review 201 citations Peoples People s China 53 2methylisoborneol methylisoborneol 2 2MIB, 2MIB MIB , (2-MIB) addition contaminants order 202 20 5 (2-MIB

Abstract Background It is justified by the high population’s morbidity and mortality rate, as well as the increasing present use of nanoparticles in this pathological context. Objectives To describe the main nanotechnology breakthroughs in the field of cardiovascular disease (CVD) and disseminate pertinent information in the literature. Methods This is a systematic review conducted between September and October 2021. The review was carried out through basic nature, following the initial script for the selective reading of articles in chronological order to collect relevant and consistent data related to the theme. Results It is evidenced the main advances of nanotechnology in the field of CVDs, namely, acute coronary syndromes (ACSs), heart failure (HF), and systemic arterial hypertension (SAH). Conclusion The importance of further and deeper studies in this area is emphasized, in order to make the already approved treatments feasible, so they can reach all publics at a low cost. populations population s rate context CVD (CVD literature 2021 nature theme CVDs namely ACSs, ACSs , (ACSs) HF, HF (HF) SAH. SAH . (SAH) emphasized feasible cost 202 (ACSs (HF (SAH 20 2

ABSTRACT Rocky Mountain Spotted Fever is a rickettsial disease caused by the bacteria Rickettsia rickettsii. In Brazil, the disease is known as Brazilian spotted fever (BSF), being the most significant tick-borne disease in the country. Among the affected patients, only 5% of cases occur in children aged one to nine years. Typical symptoms of the disease are fever, rash, headache and digestive symptoms. Neurological manifestations such as seizures, aphasia and hemiparesis have been described in few patients. This study aimed to describe the case of an infant diagnosed with BSF who presented severe signs of neurological manifestation. rickettsii Brazil BSF, , (BSF) tickborne tick borne country patients 5 years rash seizures manifestation (BSF

Blending finer powders of Ti, Zr, Ta, Sc, and Nb compounds as inoculants have been a promising strategy to modify precipitation-hardened aluminum alloys for laser-based powder bed fusion, promoting a crack-free equiaxed microstructure. However, there is still a lack of comprehensive understanding of the influence of these fine Al-Nb-B inoculant particles on the AA 2017 powder's physical characteristics and flowability during the process. The results indicate that blended powder has a similar PSD to AA 2017 powder. Furthermore, the circularity, smoothness, and morphology of the particles indicate that both inoculant and AA2017 powders do not exhibit high sphericity, but the blended powder showed slightly more agglomerated particles. Regarding rheological properties, it was observed that a higher flow energy was required to move the blended powder in unconfined conditions compared to the AA 2017 powder. Additionally, the blended powder exhibited higher compressibility and tendency to retain air in packed conditions during the deposition and spreading process. In conclusion, the physical characterization techniques combined with rheological tests have proven to be a rapid and reliable approach for assessing the impact of the finer inoculant particles' characteristics on the laser-based powder bed fusion. Ti Zr Ta Sc precipitationhardened precipitation hardened laserbased laser based fusion crackfree crack free microstructure However AlNbB Al B 201 s process Furthermore circularity smoothness AA201 sphericity properties Additionally conclusion 20 AA20 2 AA2

Abstract The aim of this study was to investigate the correlation between depressive symptoms and the occurrence of oral mucositis in children with oncological diseases treated at a reference hospital. This was a cross-sectional study conducted with individuals aged 4 to 18 years, diagnosed with primary neoplasms. Data was collected by using a questionnaire that assessed the degree of oral mucositis according to the World Health Organization index, the risk of oral mucositis according to the Child’s International Mucositis Evaluation Scale, and depressive symptoms using the Children’s Depression Inventory. The data were analyzed and subjected to Spearman’s correlation, chi-square test, and Fisher’s exact test, considering p<0.05. A statistically significant correlation was observed between depressive symptoms and the degree of oral mucositis (p = 0.044), and also between the “pain” variable within the risk of oral mucositis and depressive symptoms (p = 0.021). Based on the findings, it can be inferred that oral mucositis may be associated with the development of depressive symptoms and may be influenced by the individual’s hospitalization, thereby affecting the quality of life of pediatric patients. hospital crosssectional cross sectional 1 years neoplasms index Childs Child s Scale Childrens Children Inventory Spearmans Spearman chisquare chi square test Fishers Fisher p005 p 0 05 p<0.05 0.044, 0044 0.044 , 044 0.044) pain “pain 0.021. 0021 0.021 . 021 0.021) findings individual hospitalization patients p00 p<0.0 004 0.04 04 002 0.02 02 p0 p<0. 00 0.0 p<0 0. p<

The present study aimed to propose a new cause of odorous compounds release, i.e., the presence of antibiotics in water bodies and its toxicity to cyanobacteria, known to be the main producer of geosmin (GEO) and 2-methylisoborneol (2-MIB). Therefore, a literature review was carried out regarding the problems caused by antibiotics in aquatic environment, including cyanobacterial blooms and GEO and 2-MIB release. In addition, a bibliometric analysis was performed using the VOSviewer software based on the results obtained from the Web of Science (WOS) database. This review aims to build a scientific understanding of the problem, presenting interesting points that converge with the proposed association. It is worth mentioning that no work has been found in the literature that has proposed this relationship. Thus, based on the bibliographic survey, observations and information acquired in recent years about cyanobacterial blooms and environmental contamination by pharmaceutical drugs, one of the main causes of an earthy and musty flavour and odour in a drinking water supply is the toxicity imposed by the presence of antibiotics in aquatic environments on cyanobacteria.

This is a multicenter, cross-sectional study carried out with students regularly enrolled in undergraduate courses at eight Brazilian IFES. Data collection was conducted between October 2021 and February 2022 using an online self-completed questionnaire, which addressed sociodemographic and academic characteristics, lifestyle habits, and health conditions. Symptoms of anxiety and depression were assessed using the Depression, Anxiety, and Stress Scale-21 (DASS-21). Variables were analyzed descriptively using frequency distribution and Pearson’s chi-square test. To estimate the prevalence of symptoms of anxiety and depression, the proportion and 95% confidence interval (95%CI) were used. The level of adopted statistical significance was 5%.

Abstract Hereditary Hemochromatosis is a disorder characterized by iron deposition in several organs and hyperferritinemia. The most studied variants are linked to the HFE gene. In Brazil, surveys that characterize this population are scarce, with no sampling in the state of Rio Grande do Sul. Our objective is to carry out a data collection focusing on the profile of this population and the influence of the most frequently HFE variants. Two centers were enrolled: Hospital de Clínicas de Porto Alegre and Hospital São Vicente de Paulo. Patients with hyperferritinemia and undergoing phlebotomy were invited. Clinical data were collected, including HFE investigation. Among the descriptive data, the allele frequency of the C282Y variant (0.252) stands out, which differs from the national scenario. Systemic arterial hypertension was the most cited comorbidity. Differences between centers were observed, highlighting higher frequency of H63D cases in HSVP (p<0.01). Genotypes were stratified according to deleterious effect of C282Y variant. Higher transferrin saturation and number of phlebotomies were observed in the C282Y/C282Y cases (p<0.001). Positive family history for hyperferritinemia was more prevalent in compound heterozygotes (p<0.01). The results presented confirm the importance of encouraging such studies and reiterate the need for greater attention to this population. gene Brazil scarce Sul enrolled Paulo invited collected investigation CY C Y 0.252 0252 0 252 (0.252 scenario comorbidity HD H D p<0.01. p001 p p<0.01 . 01 (p<0.01) C282YC282Y CYCY p<0.001. p0001 p<0.001 001 (p<0.001) 0.25 025 25 (0.25 p00 p<0.0 (p<0.01 YC p000 p<0.00 00 (p<0.001 0.2 02 2 (0.2 p0 p<0. (p<0.0 (p<0.00 0. (0. p<0 (p<0. (0 p< (p<0 ( (p< (p

Abstract Introduction Despite the results of epidemiological and psychometric studies reporting comparable levels of tobacco dependence among males and females, some clinical studies have detected disparities. Some smoking cessation studies based on clinical setting programs reported poorer outcomes among women than men. Methods This retrospective cohort study aimed to compare treatment success and retention between men and women on a smoking cessation program (n = 1,014) delivered at a CAPS-AD unit in Brazil. The psychological intervention lasted 6 weeks for each group of 15 patients. Each patient had to participate in weekly group cognitive-behavioral therapy (CBT) sessions and individual medical appointments during this period. These appointments were focused on the possibility of prescribing pharmacological treatment (i.e., nicotine replacement therapy, bupropion, or nortriptyline) as adjuvants to group therapy. Results The women had lower smoking severity at baseline, more clinical symptoms, and lower prevalence of alcohol and drug use disorders and were older than the men. Females had significantly higher levels of success (36.6% vs. 29.7%) and retention (51.6% vs. 41.4%) than males. Sensitivity analysis showed that female gender was significantly associated with both retention and success, among those without drug use disorders only. Conclusion Depending on the smoking cessation setting (i.e., low and middle-income countries and mental health and addiction care units), females can achieve similar and even higher quit rates than males. Previous drug use disorder was an important confounding variable in the gender outcomes analyses. Future studies should try to replicate these positive smoking cessation effects of CBT-based group therapy plus pharmacotherapy in women. disparities n 1,014 1014 1 014 CAPSAD CAPS AD Brazil patients cognitivebehavioral cognitive behavioral CBT (CBT period i.e., ie i e (i.e. bupropion nortriptyline baseline symptoms 36.6% 366 36 (36.6 vs 29.7% 297 29 7 51.6% 516 51 (51.6 41.4% 414 41 4 only middleincome middle income units, units , units) analyses CBTbased 1,01 101 01 i.e. (i.e 36.6 3 (36. 29.7 2 51.6 5 (51. 41.4 1,0 10 0 i.e 36. (36 29. 51. (51 41. 1, (3 (5 (

RESUMEN. Este estudio, basado en la perspectiva de la psicología cultural-histórica sobre las personas con discapacidad, tenía como objetivo apreciar la dimensión subjetiva de la realidad de los niños con Síndrome Congénito del Virus del Zika (SCVZ). en el contexto escolar del desarrollo y el aprendizaje de los significados producidos por los cuidadores escolares. Para ello, se realizaron entrevistas semiestructuradas con tres cuidadores escolares de guarderías diferentes que pertenecen al sistema educativo de Campina Grande/PB. Para el análisis de datos, se realizó el procedimiento de los núcleos de significación, cuyo objetivo es aprehender las contradicciones que constituyen las producciones de significado discursiva de los participantes. Los resultados indicaron que los cuidadores de la escuela dan prioridad a la mediación pedagógica en la relación establecida con los niños con SCVZ, aunque no descuidan la instancia de cuidado en cuanto a las necesidades especiales relacionadas con la integridad psicomotora que tienen estos niños. Además, se destacó que los participantes ponen de relieve el potencial de los niños en detrimento de la falta o lesión generada por la discapacidad. RESUMEN estudio culturalhistórica cultural histórica discapacidad SCVZ. SCVZ . (SCVZ) ello GrandePB Grande PB Grande/PB datos significación Además (SCVZ

ABSTRACT This study is based by the perspective of the cultural-historical psychology on people with disabilities, aimed to apprehend the subjective dimension of the reality (or mediations) of children with Congenital Zika Virus Syndrome (CZVS) on the school context development and learning from the senses produced by school children caregivers. For this reason, semi-structured interviews were conducted with three caregivers working in three daycare centers belonging to the teaching system of education in Campina Grande/PB. For data analysis, was performed the meaning core, which aims to apprehend the contradictions that constitute the productions of discursive meaning in the participating subjects. The results indicated that school caregivers prioritize the mediation in the relationship established with children CZVS, though not disregard the instance of care in terms of the special needs related to psychomotor integrity that these children have. Furthermore, it was evidenced that the participants emphasize the children's potentialities to the detriment of the lack or injury generated by the disability. culturalhistorical cultural historical disabilities mediations CZVS (CZVS reason semistructured semi structured GrandePB Grande PB Grande/PB analysis core subjects have Furthermore childrens s disability

RESUMO. Este estudo, fundamentado na perspectiva da psicologia cultural-histórica sobre a pessoa com deficiência, teve por objetivo apreender a dimensão subjetiva da realidade (ou as mediações) das crianças com a Síndrome Congênita do Zika Vírus (SCZV) no contexto escolar de desenvolvimento e aprendizagem a partir dos sentidos produzidos por cuidadoras escolares. Para tal, foram realizadas entrevistas semiestruturadas com três cuidadoras escolares que trabalham em três creches pertencentes ao sistema de educação de ensino de Campina Grande/PB. Para análise dos dados, foi realizado o procedimento dos Núcleos de Significação, que visa à apreensão das contradições que constituem as produções de significação discursiva dos sujeitos participantes. Os resultados indicaram que as cuidadoras escolares priorizam a mediação pedagógica na relação estabelecida com as crianças com SCZV, embora não desconsiderem a instância do cuidado em termos das necessidades especiais relacionadas à integridade psicomotora que essas crianças apresentam. Ademais, foi evidenciado que as participantes salientam as potencialidades das crianças em detrimento da falta ou lesão gerada pela deficiência. RESUMO estudo culturalhistórica cultural histórica deficiência mediações SCZV (SCZV tal GrandePB Grande PB Grande/PB dados Significação apresentam Ademais

RESUMO Objetivo: identificar o perfil e a intensidade de cuidado dos avós para com os netos. Método: estudo descritivo, transversal, por amostra aleatória sistematizada, utilizado questionário semiestruturado e empreendida análise exploratória descritiva. Realizado no município do Triângulo Mineiro - Brasil, 2019. Resultados: entrevistados 392 avós cuidadores de netos, maioria mulheres (87,5%), aposentadas (67,3%), ensino fundamental incompleto (52,8%), hipertensas (71,9%) e problemas visuais (69,4%). O motivo principal de cuidado foi pelos pais trabalharem e a intensidade de cuidado junto aos netos foi intensiva. Conclusão: considera-se que a relação de cuidado entre avos e netos é um aspecto invisível à produção científica e na estruturação de programas de saúde, apesar de seus impactos à condição de saúde dos idosos. O estudo amplia a visão aos mesmos sendo necessário o desvelar deste tema para que se possa efetivamente integrá-los e fortalecer políticas públicas e sociais, notadamente no setor saúde, dado ser um fenômeno emergente. Objetivo Método descritivo transversal sistematizada descritiva Brasil 2019 Resultados 39 87,5%, 875 87,5% , 87 5 (87,5%) 67,3%, 673 67,3% 67 3 (67,3%) 52,8%, 528 52,8% 52 8 (52,8%) 71,9% 719 71 9 (71,9% 69,4%. 694 69,4% . 69 4 (69,4%) intensiva Conclusão considerase considera idosos integrálos integrá los sociais emergente 201 87,5 (87,5% 67,3 6 (67,3% 52,8 (52,8% 71,9 7 (71,9 69,4 (69,4% 20 87, (87,5 67, (67,3 52, (52,8 71, (71, 69, (69,4 2 (87, (67, (52, (71 (69, (87 (67 (52 (7 (69 (8 (6 (5 (

ABSTRACT Objective: to identify the profile and intensity of the care provided by grandparents to grandchildren. Method: a descriptive and cross-sectional study by means of systematized random sampling, with application of a semi-structured questionnaire and execution of descriptive exploratory analysis. It was conducted in 2019 in the municipality of Triângulo Mineiro - Brazil. Results: a total of 392 grandparents caring for grandchildren were interviewed, mostly women (87.5%), retired (67.3%), with incomplete Elementary School (52.8%), hypertensive (71.9%) and with vision problems (69.4%). The main reason for the caregiver role was the fact that the parents had to work, and intensity of the care provided to the grandchildren was high. Conclusion: it is considered that the care relationship between grandparents and grandchildren is an invisible aspect to the scientific production and in the structuring of health programs, despite its impacts on older adults’ health status. The study broadens their visibility, with the need to unveil this topic so that it is possible to integrate them and strengthen public and social policies, especially in the health sector, given that it is an emerging phenomenon. Objective Method crosssectional cross sectional sampling semistructured semi structured analysis 201 Brazil Results 39 interviewed 87.5%, 875 87.5% , 87 5 (87.5%) 67.3%, 673 67.3% 67 3 (67.3%) 52.8%, 528 52.8% 52 8 (52.8%) 71.9% 719 71 9 (71.9% 69.4%. 694 69.4% . 69 4 (69.4%) work high Conclusion programs adults status visibility policies sector phenomenon 20 87.5 (87.5% 67.3 6 (67.3% 52.8 (52.8% 71.9 7 (71.9 69.4 (69.4% 2 87. (87.5 67. (67.3 52. (52.8 71. (71. 69. (69.4 (87. (67. (52. (71 (69. (87 (67 (52 (7 (69 (8 (6 (5 (

RESUMEN Objetivo: identificar el perfil y la intensidad del cuidado que realizan los abuelos de sus nietos. Método: estudio descriptivo, transversal, con muestreo aleatorio sistemático, mediante cuestionario semiestructurado y análisis descriptivo exploratorio. Realizado en el municipio del Triángulo Minero - Brasil, 2019. Resultados: se entrevistó a 392 abuelos que cuidaban a sus nietos, la mayoría eran mujeres (87,5 %), jubiladas (67,3 %), con primaria incompleta (52,8 %), hipertensión (71,9 %) y problemas visuales (69,4 %). La principal razón para que cuiden de ellos era que los padres trabajaban y la intensidad del cuidado de los nietos era intensiva. Conclusión: se considera que la relación de cuidado entre abuelos y nietos es un aspecto invisible en la producción científica y en la estructuración de programas de salud, a pesar de los impactos que tiene en la condición de salud de los adultos mayores. El estudio amplía la visión sobre los mismos dado que es necesario dilucidar este tema para que puedan ser efectivamente integrados y fortalecer las políticas públicas y sociales, especialmente en el sector salud, dado que se trata de un fenómeno emergente. Objetivo Método transversal sistemático exploratorio Brasil 2019 Resultados 39 87,5 875 87 5 (87, %, % , 67,3 673 67 3 (67, 52,8 528 52 8 (52, 71,9 719 71 9 (71, 69,4 694 69 4 (69, %. . intensiva Conclusión mayores sociales emergente 201 87, (87 67, 6 (67 52, (52 71, 7 (71 69, (69 20 (8 (6 (5 (7 2 (

Abstract Objective: to analyse the prevalence of self-medication during the COVID-19 pandemic among primary education teachers and the associated factors. Methods: web-survey type of epidemiological survey performed with primary education teachers from public schools in Minas Gerais. Data collection occurred between August and September of 2020 via digital forms. The dependent variable was self-medication during the pandemic. It was analyzed by Poisson Regression, with robust variance estimation. Results: a total of 15,641 teachers from 795 cities in Minas Gerais, 81.9% female, participated in the study. It was observed that 14.5% of teachers increased the self-medication during pandemic, among them, the highest prevalence was between women (Prevalence Ratio [PR]=1.25; 95% of Confidence Interval [95%CI]=1.12;1.40), under 60 years old (PR=1.48; 95%CI=1.12;1.95), living in the urban area (PR=1.15; 95%CI=1.02;1.29), dissatisfied with the teaching work (PR=1.60; 95%CI=1.41;1.82), with worse dietary pattern (PR=1.44; 95%CI=1.33;1.56), outside the risk group for COVID-19 (PR=1.18; 95%CI=1.10;1.27), with sleep problems (PR=2.10; 95%CI=1.85;2.38), sad or regularly depressed (PR=6.29; 95%CI=4.08;9.69), and very afraid of COVID-19 (PR=1.39; 95%CI=1.23;1.57). Conclusion: self-medication was associated with sociodemographic characteristics, life habits, health conditions, and indifference or dissatisfaction with the work, characterized as a health problem among teachers. Objective selfmedication self medication COVID19 COVID 19 COVID-1 factors Methods websurvey web Gerais 202 forms Regression estimation Results 15641 15 641 15,64 79 819 81 9 81.9 female study 145 14 5 14.5 them Prevalence PR=1.25 PR125 PR =1.25 1 25 [PR]=1.25 95 95%CI=1.121.40, 95CI112140 CI 95%CI =1.12 1.40 , 12 40 [95%CI]=1.12;1.40) 6 PR=1.48 PR148 48 (PR=1.48 95%CI=1.121.95, 95CI112195 95%CI=1.12 1.95 95%CI=1.12;1.95) PR=1.15 PR115 (PR=1.15 95%CI=1.021.29, 95CI102129 95%CI=1.02 1.29 02 29 95%CI=1.02;1.29) PR=1.60 PR160 (PR=1.60 95%CI=1.411.82, 95CI141182 95%CI=1.41 1.82 41 82 95%CI=1.41;1.82) PR=1.44 PR144 44 (PR=1.44 95%CI=1.331.56, 95CI133156 95%CI=1.33 1.56 33 56 95%CI=1.33;1.56) PR=1.18 PR118 18 (PR=1.18 95%CI=1.101.27, 95CI110127 95%CI=1.10 1.27 10 27 95%CI=1.10;1.27) PR=2.10 PR210 2 (PR=2.10 95%CI=1.852.38, 95CI185238 95%CI=1.85 2.38 85 38 95%CI=1.85;2.38) PR=6.29 PR629 (PR=6.29 95%CI=4.089.69, 95CI408969 95%CI=4.08 9.69 4 08 69 95%CI=4.08;9.69) PR=1.39 PR139 39 (PR=1.39 95%CI=1.231.57. 95CI123157 95%CI=1.23 1.57 . 23 57 95%CI=1.23;1.57) Conclusion characteristics habits conditions COVID1 COVID- 20 1564 64 15,6 7 8 81. 14. PR=1.2 PR12 125 =1.2 [PR]=1.2 121 95%CI=1.121.40 95CI11214 95CI 112 =1.1 140 1.4 [95%CI]=1.12;1.40 PR=1.4 PR14 (PR=1.4 95%CI=1.121.95 95CI11219 95CI112 95%CI=1.1 195 1.9 95%CI=1.12;1.95 PR=1.1 PR11 (PR=1.1 021 95%CI=1.021.29 95CI10212 95CI102 95%CI=1.0 129 1.2 0 95%CI=1.02;1.29 PR=1.6 PR16 (PR=1.6 411 95%CI=1.411.82 95CI14118 95CI141 95%CI=1.4 182 1.8 95%CI=1.41;1.82 331 95%CI=1.331.56 95CI13315 95CI133 95%CI=1.3 156 1.5 3 95%CI=1.33;1.56 101 95%CI=1.101.27 95CI11012 95CI110 127 95%CI=1.10;1.27 PR=2.1 PR21 (PR=2.1 852 95%CI=1.852.38 95CI18523 95CI185 95%CI=1.8 238 2.3 95%CI=1.85;2.38 PR=6.2 PR62 (PR=6.2 089 95%CI=4.089.69 95CI40896 95CI408 95%CI=4.0 969 9.6 95%CI=4.08;9.69 PR=1.3 PR13 (PR=1.3 231 95%CI=1.231.57 95CI12315 95CI123 95%CI=1.2 157 95%CI=1.23;1.57 15, PR=1. PR1 =1. [PR]=1. 95%CI=1.121.4 95CI1121 11 1. [95%CI]=1.12;1.4 (PR=1. 95%CI=1.121.9 95CI11 95%CI=1. 95%CI=1.12;1.9 95%CI=1.021.2 95CI1021 95CI10 95%CI=1.02;1.2 95%CI=1.411.8 95CI1411 95CI14 95%CI=1.41;1.8 95%CI=1.331.5 95CI1331 95CI13 95%CI=1.33;1.5 95%CI=1.101.2 95CI1101 95%CI=1.10;1.2 PR=2. PR2 (PR=2. 95%CI=1.852.3 95CI1852 95CI18 2. 95%CI=1.85;2.3 PR=6. PR6 (PR=6. 95%CI=4.089.6 95CI4089 95CI40 95%CI=4. 96 9. 95%CI=4.08;9.6 95%CI=1.231.5 95CI1231 95CI12 95%CI=1.23;1.5 PR=1 =1 [PR]=1 95%CI=1.121. [95%CI]=1.12;1. (PR=1 95CI1 95%CI=1 95%CI=1.12;1. 95%CI=1.021. 95%CI=1.02;1. 95%CI=1.411. 95%CI=1.41;1. 95%CI=1.331. 95%CI=1.33;1. 95%CI=1.101. 95%CI=1.10;1. PR=2 (PR=2 95%CI=1.852. 95%CI=1.85;2. PR=6 (PR=6 95%CI=4.089. 95CI4 95%CI=4 95%CI=4.08;9. 95%CI=1.231. 95%CI=1.23;1. PR= = [PR]= 95%CI=1.121 [95%CI]=1.12;1 (PR= 95%CI= 95%CI=1.12;1 95%CI=1.021 95%CI=1.02;1 95%CI=1.411 95%CI=1.41;1 95%CI=1.331 95%CI=1.33;1 95%CI=1.101 95%CI=1.10;1 95%CI=1.852 95%CI=1.85;2 95%CI=4.089 95%CI=4.08;9 95%CI=1.231 95%CI=1.23;1 [PR] [95%CI]=1.12; (PR 95%CI=1.12; 95%CI=1.02; 95%CI=1.41; 95%CI=1.33; 95%CI=1.10; 95%CI=1.85; 95%CI=4.08; 95%CI=1.23; [PR [95%CI]=1.12 [95%CI]=1.1 [95%CI]=1. [95%CI]=1 [95%CI]= [95%CI] [95%CI

Resumo Objetivo: analisar a prevalência do aumento da automedicação durante a pandemia de COVID-19 entre professores da educação básica pública e fatores associados. Métodos: inquérito epidemiológico do tipo websurvey, realizado com professores da educação básica pública de Minas Gerais. A coleta de dados ocorreu de agosto a setembro de 2020 via formulário online. A variável dependente foi a automedicação durante a pandemia. Foi utilizada a Regressão de Poisson, com variância robusta. Resultados: participaram do estudo 15.641 professores de 795 cidades mineiras, 81,9% eram do sexo feminino. Observou-se que 14,5% dos professores aumentaram a automedicação durante a pandemia, entre eles houve maior prevalência entre as mulheres (Razão de Prevalência [RP]=1,25; Intervalo de Confiança de 95% [IC95%]=1,12;1,40), professores com menos de 60 anos (RP=1,48; IC95%=1,12;1,95), residentes da área urbana (RP=1,15; IC95%=1,02;1,29), insatisfeitos com o trabalho docente (RP=1,60; IC95%=1,41;1,82), com pior padrão alimentar (RP=1,44; IC95%=1,33;1,56), parte do grupo de risco para a COVID-19 (RP=1,18; IC95%=1,10;1,27), com problemas de sono (RP=2,10; IC95%=1,85;2,38), tristes ou regularmente deprimidos (RP=6,29; IC95%=4,08;9,69) e aqueles que apresentaram muito medo da COVID-19 (RP=1,39; IC95%=1,23;1,57). Conclusão: a automedicação esteve associada a características sociodemográficas, hábitos de vida, condições de saúde e indiferença ou insatisfação com o trabalho, configurando-se como um problema de saúde entre docentes. Objetivo COVID19 COVID 19 COVID-1 associados Métodos websurvey Gerais 202 online Poisson robusta Resultados 15641 15 641 15.64 79 mineiras 819 81 9 81,9 feminino Observouse Observou se 145 14 5 14,5 Razão RP=1,25 RP125 RP =1,25 1 25 [RP]=1,25 95 IC95%=1,121,40, IC95112140 IC IC95% =1,12 1,40 , IC95 12 40 [IC95%]=1,12;1,40) 6 RP=1,48 RP148 48 (RP=1,48 IC95%=1,121,95, IC95112195 IC95%=1,12 1,95 IC95%=1,12;1,95) RP=1,15 RP115 (RP=1,15 IC95%=1,021,29, IC95102129 IC95%=1,02 1,29 02 29 IC95%=1,02;1,29) RP=1,60 RP160 (RP=1,60 IC95%=1,411,82, IC95141182 IC95%=1,41 1,82 41 82 IC95%=1,41;1,82) RP=1,44 RP144 44 (RP=1,44 IC95%=1,331,56, IC95133156 IC95%=1,33 1,56 33 56 IC95%=1,33;1,56) RP=1,18 RP118 18 (RP=1,18 IC95%=1,101,27, IC95110127 IC95%=1,10 1,27 10 27 IC95%=1,10;1,27) RP=2,10 RP210 2 (RP=2,10 IC95%=1,852,38, IC95185238 IC95%=1,85 2,38 85 38 IC95%=1,85;2,38) RP=6,29 RP629 (RP=6,29 IC95%=4,089,69 IC95408969 IC95%=4,08 9,69 4 08 69 IC95%=4,08;9,69 RP=1,39 RP139 39 (RP=1,39 IC95%=1,231,57. IC95123157 IC95%=1,23 1,57 . 23 57 IC95%=1,23;1,57) Conclusão sociodemográficas vida configurandose configurando docentes COVID1 COVID- 20 1564 64 15.6 7 8 81, 14, RP=1,2 RP12 125 =1,2 [RP]=1,2 121 IC95%=1,121,40 IC9511214 112 =1,1 140 1,4 IC9 [IC95%]=1,12;1,40 RP=1,4 RP14 (RP=1,4 IC95%=1,121,95 IC9511219 IC95112 IC95%=1,1 195 1,9 IC95%=1,12;1,95 RP=1,1 RP11 (RP=1,1 021 IC95%=1,021,29 IC9510212 IC95102 IC95%=1,0 129 1,2 0 IC95%=1,02;1,29 RP=1,6 RP16 (RP=1,6 411 IC95%=1,411,82 IC9514118 IC95141 IC95%=1,4 182 1,8 IC95%=1,41;1,82 331 IC95%=1,331,56 IC9513315 IC95133 IC95%=1,3 156 1,5 3 IC95%=1,33;1,56 101 IC95%=1,101,27 IC9511012 IC95110 127 IC95%=1,10;1,27 RP=2,1 RP21 (RP=2,1 852 IC95%=1,852,38 IC9518523 IC95185 IC95%=1,8 238 2,3 IC95%=1,85;2,38 RP=6,2 RP62 (RP=6,2 089 IC95%=4,089,6 IC9540896 IC95408 IC95%=4,0 969 9,6 IC95%=4,08;9,6 RP=1,3 RP13 (RP=1,3 231 IC95%=1,231,57 IC9512315 IC95123 IC95%=1,2 157 IC95%=1,23;1,57 15. RP=1, RP1 =1, [RP]=1, IC95%=1,121,4 IC951121 11 1, [IC95%]=1,12;1,4 (RP=1, IC95%=1,121,9 IC9511 IC95%=1, IC95%=1,12;1,9 IC95%=1,021,2 IC951021 IC9510 IC95%=1,02;1,2 IC95%=1,411,8 IC951411 IC9514 IC95%=1,41;1,8 IC95%=1,331,5 IC951331 IC9513 IC95%=1,33;1,5 IC95%=1,101,2 IC951101 IC95%=1,10;1,2 RP=2, RP2 (RP=2, IC95%=1,852,3 IC951852 IC9518 2, IC95%=1,85;2,3 RP=6, RP6 (RP=6, IC95%=4,089, IC954089 IC9540 IC95%=4, 96 9, IC95%=4,08;9, IC95%=1,231,5 IC951231 IC9512 IC95%=1,23;1,5 RP=1 =1 [RP]=1 IC95%=1,121, [IC95%]=1,12;1, (RP=1 IC951 IC95%=1 IC95%=1,12;1, IC95%=1,021, IC95%=1,02;1, IC95%=1,411, IC95%=1,41;1, IC95%=1,331, IC95%=1,33;1, IC95%=1,101, IC95%=1,10;1, RP=2 (RP=2 IC95%=1,852, IC95%=1,85;2, RP=6 (RP=6 IC95%=4,089 IC954 IC95%=4 IC95%=4,08;9 IC95%=1,231, IC95%=1,23;1, RP= = [RP]= IC95%=1,121 [IC95%]=1,12;1 (RP= IC95%= IC95%=1,12;1 IC95%=1,021 IC95%=1,02;1 IC95%=1,411 IC95%=1,41;1 IC95%=1,331 IC95%=1,33;1 IC95%=1,101 IC95%=1,10;1 IC95%=1,852 IC95%=1,85;2 IC95%=4,08; IC95%=1,231 IC95%=1,23;1 [RP] [IC95%]=1,12; (RP IC95%=1,12; IC95%=1,02; IC95%=1,41; IC95%=1,33; IC95%=1,10; IC95%=1,85; IC95%=1,23; [RP [IC95%]=1,12 [IC95%]=1,1 [IC95%]=1, [IC95%]=1 [IC95%]= [IC95%] [IC95% [IC95 [IC9 [IC

Abstract This study aimed to evaluate the corneal epitheliotoxic effects of preservative-free ketorolac tromethamine 0.5% and diclofenac sodium 0.1% eye drops in rabbits. Seventeen New Zealand rabbits were randomly divided into three groups: the 0.5% ketorolac tromethamine group, the 0.1% diclofenac sodium group, and the control group (0.9% NaCl). For each rabbit, both eyes were treated three times daily according to their treatment group. The corneal epithelia were analyzed using scanning electron microscopy to observe the number of light, grey, and dark cells; the number of epithelial holes; and the loss of hexagonal shape. Both of the formulations administered caused changes in the healthy corneal epithelia of rabbits. Except for number of epithelial holes (p < 0.05), all the parameters showed a statistically significant difference between the groups. The number of dark cells was highest in the ketorolac tromethamine group (p<0.05). The number of grey cells was higher in the diclofenac sodium group than in the control group (p =0.003). A higher number of dark cells was associated with a smaller number of light cells (r =-0.577, p < 0.001). Loss of shape showed a direct correlation with the number of dark cells (r=0.524, p=0.002). Based on the results presented, it was possible to conclude that ketorolac tromethamine 0.5% was more toxic to rabbit corneal epithelium than diclofenac sodium 0.1%. preservativefree preservative free 05 0 5 0.5 01 1 0.1 groups 0.9% 09 9 (0.9 NaCl. NaCl . NaCl) 0.05, 005 0.05 , 0.05) p<0.05. p005 p<0.05 (p<0.05) =0.003. 0003 =0.003 003 =0.003) r =0.577, 0577 = 0.577, 577 =-0.577 0.001. 0001 0.001 001 0.001) r=0.524, r0524 524 (r=0.524 p=0.002. p0002 p=0.002 002 p=0.002) presented 0. 0.9 (0. 00 0.0 p00 p<0.0 (p<0.05 000 =0.00 =0.577 057 0.577 57 =-0.57 0.00 r=0.524 r052 52 (r=0.52 p000 p=0.00 (0 p0 p<0. (p<0.0 =0.0 =0.57 0.57 =-0.5 r=0.52 r05 (r=0.5 p=0.0 ( p<0 (p<0. =0. =0.5 =-0. r=0.5 r0 (r=0. p=0. p< (p<0 =0 =-0 r=0. (r=0 p=0 (p< =- r=0 (r= p= r=

Resumo Objetivou-se avaliar os efeitos do cetorolaco de trometamina a 0,5% e do diclofenaco de sódico a 0,1% sem conservantes na córnea de coelhos. Dezessete coelhos da raça Nova Zelândia foram aleatoriamente divididos em três grupos: o grupo de 0,5% de cetorolaco de trometamina, o grupo de 0,1% de diclofenaco sódico e o grupo controle (0,9% de NaCl). Para cada coelho, os dois olhos foram tratados três vezes ao dia durante 90 dias de acordo com o grupo de tratamento. Os epitélios da córnea foram analisados usando microscopia eletrônica de varredura para observar o número de células claras, cinzas e escuras, o número de criptas e a perda do formato celular hexagonal. Ambas as formulações administradas causaram alterações no epitélio da córnea de coelhos. Com exceção da contagem de criptas (p <0,05), todos os parâmetros apresentaram diferença estatisticamente significante entre os grupos. O número de células escuras foi maior no grupo cetorolaco de trometamina (p <0,05). O número de células cinzentas foi maior no grupo diclofenaco de sódio do que no grupo controle (p=0,003). O maior número de células escuras observado foi associado ao menor número de células claras (r=-0,577, p<0,001). A perda do formato celular mostrou uma correlação direta com o número de células escuras (r=0,524, p=0,002). O cetorolaco de trometamina 0,5% foi mais tóxico para o epitélio da córnea de coelhos do que o diclofenaco de sódio a 0,1%. Objetivouse Objetivou se 05 0 5 0,5 01 1 0,1 grupos 0,9% 09 9 (0,9 NaCl. NaCl . NaCl) coelho tratamento hexagonal p <0,05, 005 <0,05 , <0,05) <0,05. p=0,003. p0003 p=0,003 003 (p=0,003) r=0,577, r0577 r r= 0,577, 577 (r=-0,577 p<0,001. p0001 p<0,001 001 p<0,001) r=0,524, r0524 524 (r=0,524 p=0,002. p0002 p=0,002 002 p=0,002) 0, 0,9 (0, 00 <0,0 p000 p=0,00 (p=0,003 r=0,577 r057 0577 0,577 57 (r=-0,57 p<0,00 r=0,524 r052 52 (r=0,52 (0 <0, p00 p=0,0 (p=0,00 r=0,57 r05 057 0,57 (r=-0,5 p<0,0 r=0,52 (r=0,5 ( <0 p0 p=0, (p=0,0 r=0,5 r0 (r=-0, p<0, (r=0, < p=0 (p=0, r=0, (r=-0 p<0 (r=0 p= (p=0 r=0 (r=- p< (r= (p= (r

RESUMEN Objetivo: Mapear, en la literatura científica, las acciones adoptadas para promover la seguridad del paciente con covid-19 en el contexto hospitalario. Métodos: Se trata de una revisión de ámbito de acuerdo con el Instituto Joanna Briggs, utilizando el Checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. En abril de 2022, fueron realizadas búsquedas en nueve fuentes de datos. Los resultados fueron sintetizados en un cuadro y analizados de manera descriptiva. Resultados: Fueron seleccionados 15 estudios para componer la muestra final. La mayoría de los artículos se refieren a estudios de cohorte, seguidos de ensayos clínicos. Cuanto las áreas de actuación, notado predominancia de los centros quirúrgicos, seguidos por Unidades de Cuidados Intensivos adulto y pediátrica. Conclusiones: Con esta revisión, fue posible mapear medidas como planes de contingencia y reorganización de lechos, cuartos y salas quirúrgicas, además del aislamiento y distanciamiento practicados por pacientes y profesionales. Objetivo Mapear científica covid19 covid 19 covid-1 hospitalario Métodos Briggs MetaAnalyses Meta Analyses 2022 datos descriptiva Resultados 1 final cohorte clínicos actuación quirúrgicos pediátrica Conclusiones lechos quirúrgicas profesionales covid1 covid- 202 20 2

ABSTRACT Objective: Map, in the scientific literature, the actions taken to promote the safety of patients with covid-19 in the hospital context. Methods: This is a scoping review according to the Joanna Briggs Institute, using the Checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. In April 2022, searches were performed on nine data sources. The results were summarized in a table and analyzed descriptively. Results: Fifteen studies were selected to compose the final sample. Most articles refer to cohort studies, followed by clinical trials. As for the areas of activity, there was a predominance of surgical centers, followed by adult and pediatric Intensive Care Units. Conclusions: With this review, it was possible to map measures such as contingency plans and reorganization of beds, rooms, and operating rooms, in addition to the isolation and distancing practiced by patients and professionals. Objective Map literature covid19 covid 19 covid-1 context Methods Institute MetaAnalyses Meta Analyses 2022 sources descriptively Results sample trials activity centers Units Conclusions beds rooms professionals covid1 1 covid- 202 20 2

RESUMO Objetivo: Mapear, na literatura científica, as ações adotadas para promover a segurança do paciente com covid-19 no contexto hospitalar. Métodos: Trata-se de uma revisão de escopo de acordo com o Instituto Joanna Briggs, utilizando o Checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. Em abril de 2022, foram realizadas buscas em nove fontes de dados. Os resultados foram sintetizados em um quadro e analisados de forma descritiva. Resultados: Foram selecionados 15 estudos para compor a amostra final. A maioria dos artigos se refere a estudos de coorte, seguidos de ensaios clínicos. Quanto às áreas de atuação, notou-se predominância dos centros cirúrgicos, seguidos por Unidades de Terapia Intensiva adulto e pediátrica. Conclusões: Com esta revisão, foi possível mapear medidas como planos de contingência e reorganização de leitos, quartos e salas de cirurgias, além do isolamento e distanciamento praticados pelos pacientes e profissionais. Objetivo Mapear científica covid19 covid 19 covid-1 hospitalar Métodos Tratase Trata Briggs MetaAnalyses Meta Analyses 2022 dados descritiva Resultados 1 final coorte clínicos atuação notouse notou cirúrgicos pediátrica Conclusões leitos cirurgias profissionais covid1 covid- 202 20 2

Abstract We investigated the occurrence of gastrointestinal parasites in dogs in rural areas of the municipality of Painel, Santa Catarina, Brazil. For this, 91 canine feces samples were collected from 82 farms between August, 2017 and January, 2018. These fecal materials were processed using the techniques of spontaneous sedimentation, centrifugation-floatation in zinc sulfate and Ziehl-Neelsen staining. A questionnaire in the form of an interview was administered to the dogs’ owner and information about the farm and the main care provided for the dogs was obtained. Among 91 sampled dogs, 27 (29.7%) were positive for at least one parasite species. Ancylostoma was the most prevalent genus (16.5%), followed by Giardia duodenalis (14.3%), Trichuris vulpis (6.6%), Toxocara canis (5.5%), Entamoeba spp. (4.8%), Cryptosporidium spp. (3.3%) and Taeniidae (1.1%). Most dogs do not receive veterinarian care and rarely received antiparasitic treatment. They were free to roam and had free access to animal remains and garbage, which was reflected in the significant associations with the occurrence of parasites that were found. We conclude that rural dogs harbor gastrointestinal parasites, but that their owners are unaware of the risks that these parasites can bring to human health. Painel Catarina Brazil this 9 8 August 201 January 2018 sedimentation centrifugationfloatation centrifugation floatation ZiehlNeelsen Ziehl Neelsen staining obtained 2 29.7% 297 29 7 (29.7% species 16.5%, 165 16.5% , 16 5 (16.5%) 14.3%, 143 14.3% 14 3 (14.3%) 6.6%, 66 6.6% 6 (6.6%) 5.5%, 55 5.5% (5.5%) spp 4.8%, 48 4.8% 4 (4.8%) 3.3% 33 (3.3% 1.1%. 11 1.1% . 1 (1.1%) treatment garbage found health 20 29.7 (29.7 16.5 (16.5% 14.3 (14.3% 6.6 (6.6% 5.5 (5.5% 4.8 (4.8% 3.3 (3.3 1.1 (1.1% 29. (29. 16. (16.5 14. (14.3 6. (6.6 5. (5.5 4. (4.8 3. (3. 1. (1.1 (29 (16. (14. (6. (5. (4. (3 (1. (2 (16 (14 (6 (5 (4 ( (1

Resumo Foi investigada a ocorrência de parasitos gastrintestinais com potencial zoonótico, em cães de área rural do munícipio de Painel, Santa Catarina, Brasil. Para isso, foram colhidas amostras de fezes de 91 cães de 82 propriedades rurais, no período de agosto de 2017 a janeiro de 2018. Este material fecal foi processado pelas técnicas de sedimentação espontânea, centrífugo-flutuação em sulfato de zinco e coloração pelo Ziehl-Neelsen. Um questionário em forma de entrevista foi aplicado aos tutores dos cães e foram obtidas informações sobre a propriedade rural e principais cuidados com os cães. Entre as 91 amostras de fezes, em 27 (29,7%) foi detectada a presença de parasitos gastrintestinais, sendo Ancylostoma o gênero mais prevalente (15 / 16,5%), seguido por Giardia duodenalis (13 / 14,3%), Trichuris vulpis (6 / 6,6%), Toxocara canis (5 / 5,5%), Entamoeba spp. (4 / 4,8%), Cryptosporidium spp. (3 / 3,3%) e Taeniidae (1 / 1,1%). A maioria dos cães não recebia cuidados veterinários ou antiparasitários. Concluiu-se que os cães de área rural albergam parasitos gastrintestinais, porém seus tutores desconhecem os riscos que esses parasitos podem trazer para a saúde humana. zoonótico Painel Catarina Brasil isso 9 8 rurais 201 2018 espontânea centrífugoflutuação centrífugo flutuação ZiehlNeelsen. ZiehlNeelsen Ziehl Neelsen. Neelsen Ziehl-Neelsen 2 29,7% 297 29 7 (29,7% 15 16,5%, 165 16,5% , 16 5 16,5%) 13 14,3%, 143 14,3% 14 3 14,3%) 6 ( 6,6%, 66 6,6% 6,6%) 5,5%, 55 5,5% 5,5%) spp 4 4,8%, 48 4,8% 4,8%) 3,3% 33 1 1,1%. 11 1,1% . 1,1%) antiparasitários Concluiuse Concluiu se humana 20 29,7 (29,7 16,5 14,3 6,6 5,5 4,8 3,3 1,1 29, (29, 16, 14, 6, 5, 4, 3, 1, (29 (2