ABSTRACT: Derby Square is a relevant public space in Recife, recognized as a historic garden and Brazilian cultural heritage due to Burle Marx’s intervention in the 1930s. However, its construction dates back to the 1920s, the period of modernization of the city, with scarce discussions, until now, about its initial design. This article aims to contribute to the historiographical process of Derby Square, focusing mainly on the 1920s and 1930s, ranging from its construction to Burle Marx’s remodeling. To this end, the technique of indirect documentation was adopted, using primary written and visual sources not yet discussed or published, allowing an investigation, recording, analysis, and interpretation of events and the formulation of a new narrative. With this research, it is understood that Derby Square can be interpreted as a palimpsest, in which the elements of the different periods that make up its history are also responsible for highlighting this garden as cultural heritage. ABSTRACT Recife Marxs Marx s 1930s However city discussions now design remodeling end adopted published investigation recording analysis narrative research palimpsest

RESUMO: A Praça do Derby é um relevante espaço público do Recife, reconhecido como jardim histórico e patrimônio cultural brasileiro devido à intervenção de Burle Marx nos anos 1930. No entanto, sua construção remonta à década de 1920, período de modernização da cidade, pouco tendo se discutido, até o momento, sobre sua concepção inicial. Neste artigo busca-se contribuir para o processo historiográfico da Praça do Derby, com foco principalmente nas décadas de 1920 e 1930, que abrangem desde sua construção até a remodelação de Burle Marx. Para isso, foi adotada a técnica de documentação indireta, utilizando fontes primárias escritas e visuais ainda não discutidas ou publicadas, o que permite investigar, registrar, analisar e interpretar os acontecimentos, além de formular uma nova narrativa. Por meio desta pesquisa, entende-se que a Praça do Derby pode ser interpretada como um palimpsesto, no qual os elementos dos diferentes períodos que compõem sua história também são responsáveis por evidenciar esse jardim como patrimônio cultural. RESUMO Recife 1930 entanto cidade discutido momento inicial buscase busca 192 isso indireta publicadas investigar registrar acontecimentos narrativa pesquisa entendese entende palimpsesto 193 19 1

ABSTRACT Objective The objective of this paper is to evaluate the profile of the cases of conjuntivitis treated in the emergency department of the Banco de Olhos Hospital, emphasizing the infectious conjunctivitis, and compare before and after the onset of the Coronavirus pandemic and social isolation, both in public and private health care system. Methods A retrospective and transversal study where electronic files of the patients who visited the emergency department between March and June of 2019 and 2020 were reviewed. Results A significant reduction in the number of consultations at the emergency department was observed after the beginning of the pandemic. From March to June 2019, 21.678 visits were made. In the same period of 2020, this number was 14.194, a drop of 34.5%. The rate of visits having conjunctivitis as main cause also dropped significantly. Infectious conjunctivitis was the one who showed the highest decrease. In 2019, it was responsible for 30.2% of the visits and, in 2020, for 15.5%. There were no changes regarding the gender, but a significantly increase in patients’ age was observed. Conclusion The study showed a dramatic reduction in the number of visits at the emergency department of ophthalmology regarding infectious conjunctivitis after the beginning of the pandemic, and we believe that the cause is related with an increase of hygiene care, social isolation and restrictions caused by the Coronavirus pandemic. Hospital system 201 202 reviewed 21678 21 678 21.67 made 14194 14 194 14.194 345 34 5 34.5% decrease 302 30 2 30.2 155 15 15.5% gender 20 2167 67 21.6 1419 1 19 14.19 3 34.5 30. 15.5 216 6 21. 141 14.1 34. 15. 14.

RESUMO Objetivo O objetivo deste trabalho é avaliar o perfil epidemiológico das conjuntivites atendidas no Pronto Socorro do Hospital Banco de Olhos de Porto Alegre (HBO) com destaque à conjuntivite infecciosa e compará-lo aos atendimentos após o início da pandemia pelo Coronavírus, observando como o isolamento social e as questões de higiene amplamente enfatizadas e estimuladas desde o início a pandemia influenciaram o número de conjuntivites bacterianas e virais atendidas neste serviço de referência. Métodos Estudo transversal e retrospectivo através da análise dos prontuários eletrônicos dos pacientes atendidos no serviço de emergência do HBO no período entre março e junho de 2019 e 2020. Resultados Observou-se uma redução significativa no número de atendimento no departamento de emergência após o início da pandemia. De março a junho de 2019, 21.678 atendimentos foram realizados. No mesmo período de 2020, este número foi de 14.194, uma queda de 34,5%. O índice de conjuntivite como principal causa da visita oftalmológica diminuiu significativamente, sendo a conjuntivite infecciosa aquela que teve a maior queda. Em 2019, a mesma foi responsável por 30,2% dos atendimentos e, em 2020, por 15,5%. Não foi observado mudanças em relação ao sexo mais atendido, no entanto, observou-se um aumento significante na idade do paciente. Conclusão O estudo demonstrou uma importante redução no número de atendimentos na emergência em relacionados à conjuntivite infecciosa após o início da pandemia pelo Coronavírus. Acredita-se que este fato esteja diretamente relacionado ao aumento dos cuidados de higiene, isolamento social e a restrições impostas pela pandemia. (HBO comparálo compará lo Coronavírus referência 201 2020 Observouse Observou se 21678 21 678 21.67 realizados 14194 14 194 14.194 345 34 5 34,5% significativamente 302 30 2 30,2 155 15 15,5% atendido entanto observouse observou paciente Acreditase Acredita 20 202 2167 67 21.6 1419 1 19 14.19 3 34,5 30, 15,5 216 6 21. 141 14.1 34, 15, 14.

Abstract This study aimed to describe the effects of social distancing due to the COVID-19 pandemic on physical and mental health, chronic disease management, and economic situation in adults from a southern Brazilian state. Data from the baseline of the PAMPA (Prospective Study About Mental and Physical Health) cohort, a population-based, longitudinal study is presented. An online-based questionnaire was used to assess the variables pre- and during social distancing. Most of the respondents (N=2,321) were women (76.7%), white (90.6%), had at least university degree (66.7%), and were overweight or obese (53.3%). Nearly 40% were not able to work from home and 45.3% had monthly income reduced during social distancing. Moderate-to-severe symptoms of depression and anxiety increased 7.3x and 8.4x from before to during social distancing. Three quarters reported low back pain (74.2%; 95%CI: 71.9%, 76.3%) during the same period while the prevalence of physical inactivity increased 31.2%. Managing chronic conditions was harder during social distancing for 28.5% of the participants. Roughly 40% reported that did not seek medical assistance even when necessary during this period. COVID-19 pandemic has disrupted the health of adults from a southern Brazilian state in several aspects.

Abstract The use of creep feeding for preweaning piglets is important to improve the performance of the piglets. The objective of this experiment was evaluate the effect of using or altering the position of piglet’s creep feeder during lactation on piglet’s performance and on behavior of piglets and sows kept in a hot climate environment. Forty-five sows and their litters at 10 days of lactation were randomly distributed into three treatments: front feeder (FF) - near the side of the sow’s head; back feeder (BF) - near the side of the rump of the sow; and no feeder (NF). All piglets were weighed individually to evaluate the average weight, weight gain and coefficient of variation of the weight. Behavior assessments of the piglets and sows were recorded in 3 period. At 15 and 21 d, piglets of the FF treatment were heavier (P ≤ 0.0001) than piglets of the other treatments. At 10-21d piglets of FF treatment had 76.2% less belly nosing behavior than the NF piglets (P=0.015). The treatments had no impact on behavior of the sows. The creep feeders positioned in the front of the farrowing crate increased piglet growth rate and decreased frequency of belly nosing behavior.

Abstract Background: Organoid cultures are primary cultures that maintain architectural characteristics and the relationships between cells, as well as the extracellular matrix. They are alternatives for pathophysiological or therapeutic investigation rather than animal and in vitro tests. Objective: Development of a cutaneous organoid culture model, aiming at the study of radiation-induced melanogenesis. Method: A validation study, which involved biopsies of the skin of the back of the adult ear. One sample was irradiated with different doses of UVB, UVA, or visible light (VL); the other was maintained in the dark for 72 h. The viability of the tissues was evaluated from the morphological and architectural parameters of the histology, and the expression of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene, by real-time polymerase chain reaction (PCR). The radiation-induced melanin pigmentation was standardized according to the doses of each radiation and evaluated by digital image analysis (Fontana-Masson). Results: The primary skin culture was standardized at room temperature using DMEM medium. The doses of UVB, UVA, and VL (blue light) that induced differential melanogenesis were: 166 mJ/cm2, 1.524 J/cm2, and 40 J/cm2. The expression of the GAPHD constitutional gene did not differ between the sample of skin processed immediately after tissue collection and the sample cultured for 72 h in the standardized protocol. Study limitations: This was a preliminary study that evaluated only the viability and integrity of the melanogenic system, and the effect of the radiation alone. Conclusions: The standardized model maintained viable melanocytic function for 72 h at room temperature, allowing the investigation of melanogenesis induced by different forms of radiation.

Abstract: Syringocystadenoma papilliferum and tubular apocrine adenoma are rare benign sweat gland tumors. Syringocystadenoma papilliferum occurs alone or in association with other tumors. Although it is rare, the association of tubular apocrine adenoma with syringocystadenoma papilliferum developing in a sebaceous nevus on the scalp is well documented. However, the co-existence of these two tumors without the background of a sebaceous nevus has not been frequently reported. Syringocystadenoma papilliferum and tubular apocrine adenoma may have a histopathological overlap, but a few cases of a syringocystadenoma papilliferum combined with a tubular apocrine adenoma have been reported. Herein we describe an unusual case of syringocystadenoma papilliferum co-existing with a tubular apocrine adenoma located on the back of a 14-year-old patient in the absence of a pre-existing sebaceous nevus.

Abstract: A 54 year-old woman with a 3-year history of rheumatoid arthritis (RA) consulted us because of weight loss, fever and skin eruption. On physical examination, erythematous plaques with a pseudo-vesicular appearance were seen on the back of both shoulders. Histological examination was consistent with rheumatoid neutrophilic dermatosis (RND). After three days of prednisone treatment, the skin eruption resolved. RND is a rare cutaneous manifestation of seropositive RA, characterized by asymptomatic, symmetrical erythematous plaques with a pseudo-vesicular appearance. Histology characteristically reveals a dense, neutrophilic infiltrate with leucocitoclasis but without other signs of vasculitis. Lesions may resolve spontaneously or with RA treatment. This case illustrates an uncommon skin manifestation of active rheumatoid arthritis.

Background Medical training is a stressing situation, making medical students vulnerable to psychiatric disorders, such as depression and anxiety. Objective The study aimed to assess the prevalence of stress and coping in students of a public medical school in Brazil, comparing the groups from the first and sixth years of training. Methods Through a cross-sectional, observational study, a sample of 232 first and sixth-year regularly registered medical students has been evaluated. Students filled a socio-demographic questionnaire, the Lipp Inventory of Stress Symptoms (ISSL), and the Coping Strategies Inventory (CSI). Results From the total sample of 232 students, 110 were first-year students and 122 sixth-year students. Stress symptoms were significantly higher in first-year students (49.1%) than in the sixth-year group (33.6%; p = 0.018). Variables significantly associated with stress were: year of the training (1st year > 6th year), income (lower > higher income), satisfaction with the training (dissatisfied > satisfied) and the use of escape/avoidance copying strategy (positive association). Discussion Considering the higher stress symptoms among first-year medical students and the positive association of the escape/avoidance copying strategy with stress, strategies must be developed to enable students starting medical school to be better at coping with this stressful situations.

Psoriasiform Keratosis is a rare clinic entity. The etiopathogenesis remains unknown and the disease is characterized by a solitary, scaly or keratotic papule, or plaque mainly located on the extremities. Histopathological features closely resemble those of psoriasis. We report the case of a 70-year-old woman presenting a solitary and asymptomatic keratotic plaque, located on the back of the left leg, unresponsive to topical corticosteroids. We performed an excisional biopsy and histopathology was consistent with psoriasiform keratosis.

Acne fulminans é uma forma grave e rara de acne que pode ser evolução da acne vulgar, principalmente em adolescentes do sexo masculino, ou ser precipitada durante o tratamento com isotretinoína oral. A artrite pode ocorrer como grave complicação na acne fulminans e já foi relatada como efeito adverso raro da isotretinoína. O acometimento das articulações sacroilíacas ocorre em 21% das artrites associadas à acne fulminans. Relatase caso de paciente masculino, 18 anos, que desenvolveu acne fulminans a partir de acne vulgar grau IV/conglobata e após resolução do quadro inflamatório, foi iniciado tratamento da acne com isotretinoína. Com 30 dias de uso do retinóide, o paciente iniciou dor lombar com piora rápida, progressiva que o incapacitou de deambular.

Acne fulminans is a rare and severe form of acne that may evolve from acne vulgaris, especially in male adolescents, or occur as an adverse effect of oral isotretinoin. Arthritis is a serious clinical manifestation when the musculoskeletal system is compromised by AF and has been reported as a rare adverse effect of isotretinoin. Involvement of the sacroiliac joints occurs in 21% of acne fulminans cases. We present the case of a 18-year-old male patient in whom acne fulminans evolved from acne vulgaris grade IV and after inflammation resolution started treatment with oral isotretinoin. Within a 30-day period of retinoid treatment he presented with back pain followed by rapid, progressive inability to deambulate.

FUNDAMENTOS: A laserterapia de baixa potência e os inibidores seletivos da ciclooxigenase-2 (ICOX2) vem sendo muito utilizados para modular a resposta inflamatória, entretanto, os seus efeitos na reepitelização de feridas não são bem compreendidos. OBJETIVO: Avaliar os efeitos isolados e combinados da laserterapia de baixa potência e da ICOX2 na reepitelização de ferida incisional na pele de camundongos. MÉTODO: Foi induzida uma ferida de 1 cm no dorso de cada camundongo, que foram divididos em quatro grupos (N=20): Controle, Laserterapia, Tratados com celecoxib e Terapia conjugada. Os animais dos grupos celecoxib e Terapia conjugada foram tratados com celecoxib por 10 dias antes da incisão cutânea. As feridas experimentais foram irradiadas com laserterapia de baixa potência He-Ne (632nm, dose: 4J/cm2) em varredura, por 12 segundos durante três dias consecutivos nos grupos Laserterapia e Terapia conjugada. Os animais foram sacrificados no 3º dia de pós-operatório. Amostras das feridas foram coletadas e coradas (Tricromio de Masson) para análise histomorfométrica. RESULTADOS: Tanto o grupo Laserterapia, quanto o grupo celecoxib, mostrou aumento da reepitelização cutânea em relação ao grupo Controle, entretanto, o grupo Terapia conjugada não apresentou diferenças. Quanto à queratinização o grupo Laserterapia e Terapia conjugada apresentaram redução dos queratinócitos, comparados com o grupo Controle. CONCLUSÕES: Os resultados mostram que o uso da laserterapia de baixa potência e da ICOX2 isoladamente aumentam as células epiteliais, mas somente a laserterapia de baixa potência reduziu os queratinócitos cutâneos. O tratamento conjugado restabelece a reepitelização inata e dimunui a queratinização, embora ocorra uma acelerada contração da ferida com melhora na organização da ferida na pele de camundongos.

BACKGROUND: Low level laser therapy and cyclooxygenase-2 (ICOX2) selective inhibitors have been widely used to modulate inflammatory response; however, their effect on wound reepithelialization are not well understood. OBJECTIVE: To evaluate the isolated and combined effects of low level laser therapy and ICOX2 in the reepithelization of skin incisional wounds in mice. METHODS: We induced a 1-cm wound on the back of each mouse, which were divided into four groups (N = 20): control, laser therapy, treated with celecoxib and combined therapy. The animals in the celecoxib and combined therapy groups were treated with celecoxib for 10 days before skin incision. The experimental wounds were irradiated with He-Ne low power laser (632nm, dose: 4J/cm2) in scanning for 12 seconds during three consecutive days in the laser therapy and combined therapy groups. The animals were sacrificed 3 days after surgery. Samples of the wounds were collected and stained (Masson's Trichrome) for histomorphometric analysis. RESULTS: Both the laser therapy group and the celecoxib group showed an increase in skin reepithelialization compared to the control group; however, the combined therapy group showed no differences. As for keratinization, the laser therapy and combined therapy groups showed a reduction in keratinocytes compared with the control group. CONCLUSION: The results show that the use of low level laser therapy and ICOX2 in isolation increases epithelial cells, but only low level laser therapy reduced skin keratinocytes. The combined treatment restores innate epithelialization and decreases keratinization in spite of accelerating wound contraction with improvement in the organization of the wound in the skin of mice.

A distribuição de compostos aromáticos selecionados e a microbiologia foram avaliados em sedimentos superficiais do Manguezal de Suruí, Baía de Guanabara. Amostras foram coletadas em 23 pontos e determinados a granulometria, matéria orgânica, compostos aromáticos, atividade microbiológica, biopolímeros e a topografia. A concentração dos compostos aromáticos foi distribuída em manchas por todo o manguezal e sua concentração total mais elevada foi encontrada na área central do manguezal. A granulometria diferiu da maioria dos manguezais, uma vez que no Manguezal de Suruí existem chernies nas bordas e na frente dos manguezais e areia através da superfície inteira, impedindo o relacionamento entre granulometria e os hidrocarbonetos. Uma média de 10% p/p da matéria orgânica foi obtida e os biopolímeros apresentaram concentrações elevadas, especialmente na área central e fundo do Manguezal. Os biopolímeros se distribuíram em altas concentrações. A presença de finos sedimentos é fator importante na acumulação de hidrocarbonetos. Na concentração elevada de matéria orgânica e de biopolímeros, topografia com chernies e as raízes que protegem os manguezais, áreas mais calmas são criadas, com depósito do material transportado pela ação das ondas. Comparadas às distribuições globais, as concentrações das substâncias aromáticas neste manguezal podem ser classificadas de moderadas a elevadas, demonstrando que a área estudada está altamente impactada.

The distribution of selected aromatic compounds and microbiology were assessed in superficial sediments from Suruí Mangrove, Guanabara Bay. Samples were collected at 23 stations, and particle size, organic matter, aromatic compounds, microbiology activity, biopolymers, and topography were determined. The concentration of aromatic compounds was distributed in patches over the entire mangrove, and their highest total concentration was determinated in the mangrove's central area. Particle size differed from most mangroves in that Suruí Mangrove has chernies on the edges and in front of the mangrove, and sand across the whole surface, which hampers the relationship between particle size and hydrocarbons. An average @ 10% p/p of organic matter was obtained, and biopolymers presented high concentrations, especially in the central and back areas of the mangrove. The biopolymers were distributed in high concentrations. The presence of fine sediments is an important factor in hydrocarbon accumulation. With high concentration of organic matter and biopolymers, and the topography with chernies and roots protecting the mangrove, calmer areas are created with the deposition of material transported by wave action. Compared to global distributions, concentrations of aromatic compounds in Suruí Mangrove may be classified from moderate to high, showing that the studied area is highly impacted.