ABSTRACT Objective: To evaluate severe acute respiratory syndrome surveillance in a pediatric unit. Methods: Descriptive study of reported severe acute respiratory syndrome cases with the detection of respiratory viruses in the nasopharyngeal sample of patients hospitalized between 2013 and 2019, in a reference hospital in the Federal District, Brazil. Results: A total of 269 children had one or more viruses detected, resulting in 280 viruses, of which 152 (54%) were respiratory syncytial virus. The detection of respiratory syncytial virus was higher during the autumn-winter period. Children´s median age was 6.9 months, 156 (58%) were male, 104 (39%) had comorbidity, 197 (73%) required mechanical ventilation, 241 (90%) received antibiotics, and 146 (54%) oseltamivir. There were 19 (7%) deaths. The median time from symptom onset to sample collection was 5 days and the median time from sample collection to final results was 6 days. Conclusions: The system needs to reduce the time to deliver results so that inappropriate use of antibiotics and antivirals can be avoided. Moreover, the burden of viral pneumonia was relevant and the system must be flexible enough to include emerging viruses in order to be useful in responding to public health emergencies caused by respiratory viruses. Objective unit Methods 201 2019 District Brazil Results 26 detected 28 15 54% 54 (54% autumnwinter autumn winter period Childrens Children s 69 9 6. months 58% 58 (58% male 10 39% 39 (39% comorbidity 73% 73 (73% ventilation 24 90% 90 (90% 14 oseltamivir 1 7% 7 (7% deaths Conclusions avoided Moreover 20 2 (54 (58 3 (39 (73 (90 (7 (5 (3 (9 (

RESUMO Objetivo: Avaliar a vigilância da síndrome respiratória aguda grave em uma unidade pediátrica. Métodos: Estudo descritivo dos casos de síndrome respiratória aguda grave, notificados e com a detecção de vírus respiratório em amostra de nasofaringe de pacientes internados entre 2013 e 2019, em um hospital de referência do Distrito Federal. Resultados: Um total de 269 crianças tiveram algum vírus detectado, resultando em 280 vírus, sendo 152 (54%) vírus sincicial respiratório. A detecção do vírus sincicial respiratório foi maior durante o período de outono-inverno. A mediana da idade das crianças foi de 6,9 meses, 156 (58%) eram do sexo masculino, 104 (39%) tinham comorbidade, 197 (73%) necessitaram de ventilação mecânica, 241 (90%) receberam antibióticos e 146 (54%) oseltamivir. Ocorreram 19 (7%) óbitos. A mediana do tempo desde o início dos sintomas até a coleta da amostra foi de 5 dias, e do tempo da coleta até o resultado foi de 6 dias. Conclusões: O sistema necessita reduzir o tempo do resultado final para que seja possível evitar o uso inadequado de antibióticos e antivirais. Ademais, o impacto das pneumonias virais foi relevante e o sistema deve ser flexível suficiente para incluir vírus emergentes, para ser útil na resposta às emergências de saúde pública causada por vírus respiratórios. Objetivo pediátrica Métodos 201 2019 Federal Resultados 26 detectado 28 15 54% 54 (54% outonoinverno. outonoinverno outono inverno. inverno outono-inverno 69 9 6, meses 58% 58 (58% masculino 10 39% 39 (39% comorbidade 73% 73 (73% mecânica 24 90% 90 (90% 14 oseltamivir 1 7% 7 (7% óbitos dias Conclusões antivirais Ademais emergentes respiratórios 20 2 (54 (58 3 (39 (73 (90 (7 (5 (3 (9 (

Abstract When processed conventionally, aluminum-bronze alloys with high mechanical strength require machining after the raw state of fusion, and the waste (chips), if not reused, can cause problems for the environment and costs for the company. Therefore, this article proposes an alternative for recycling aluminum bronze through the new route via Powder Metallurgy (PM), analyzing the resulting microstructure. This study compares the microstructures of the aluminum bronze derived from extraction (the samples received - SR) and the state after the powder metallurgy (PM) process with the addition of vanadium carbides (VC). The study also analyzes the distribution of VC in the microstructure of the PM composite as well as the influence of the TQ30 heat treatment on this composite. For the PM process, aluminum alloy and bronze chips were ground together with vanadium carbide (VC) in a high-energy mill for 50 hours. The powders obtained were pressed uniaxially (400 MPa) to achieve good compaction. The samples were then sintered (900°C/lh), water quenched (900°C/2h), and subjected to treatment according to the TQ30 standard, which, in addition to the previous treatments, also includes tempering at 500°C for 2 hours (ASTM B150/B150M-12 standard). The microstructure observed in the SR samples was martensitic (in needles), with secondary phases dispersed in the matrix. On the other hand, the microstructure of the PM samples showed equiaxed grains of the alpha phase (a), as well as the secondary phases kapa (k) and beta line (β1), in contrast to the needle-shaped microstructure of the conventional melting process. conventionally aluminumbronze fusion chips, , (chips) reused company Therefore PM, (PM VC. . TQ TQ3 (VC highenergy energy 5 400 (40 MPa compaction 900°C/lh, 900Clh Clh 900°C/lh 900 C lh (900°C/lh) 900°C/2h, 900C2h Ch 900°C/2h 2h h (900°C/2h) standard which treatments 500C 500 ASTM B150/B150M12 B150B150M12 BBM B150/B150M 12 B150 B150M B M B150/B150M-1 standard. standard) needles, needles needles) matrix hand a, (a) k (k β1, β1 β (β1) needleshaped needle shaped (chips 40 (4 90 (900°C/lh (900°C/2h B150M12 B150/B150M1 B150B150M1 B150B150M 1 B15 BM B150/B150M- (a (β1 4 ( 9 B150M1 B1 (β

ABSTRACT The investigation aims to analyze the technical viability of addition the waste from the filter-press from the mineral coal treatment process (TFP) and bottom ash from a thermoelectric (CP), in ceramic paste on the laboratory scale. Physical-chemical characterization and waste classification tests were carried out. Subsequently, ten formulations were developed through the mixture design (DoE), incorporating these residues into a standard clay ceramic paste (STD). The samples were formed by extrusion without vacuum and subjected to heat treatment in an oven and fired in a muffle at 900 °C. The evaluated technological properties were: shrinkage of drying and firing, water absorption and mechanical resistance and, finally, efflorescence tests and phytotoxicological analysis were performed. The results of solid waste classification, indicated these as not being dangerous (Class II-B - inert). The technical analysis of the samples show that compared to the clay ceramic standard formulation (STD), the other mixtures obtained results within the technical parameters, which can later be carried out in an industrial scale test. Although the mechanical tests with waste incorporation were below the standard formulation (STD), a test on an industrial scale is not discarded. In the efflorescence test, it was observed that there was no presence of soluble salts. And finally, in the phyto-toxicological test, with Allium cepa L. of a formulation with aggregation of all raw materials, it presented a result marginally similar to the standard, proving itself capable of reproduction on an industrial scale. filterpress filter press TFP (TFP CP, CP , (CP) Physicalchemical Physical chemical Subsequently DoE, DoE (DoE) STD. STD . (STD) 90 C °C firing finally performed Class IIB II B inert. inert inert) STD, parameters discarded salts phyto toxicological L materials (CP (DoE (STD 9

RESUMO A investigação teve por objetivo analisar a viabilidade técnica de incorporação do resíduo proveniente do filtro prensa do processo de beneficiamento do carvão mineral (TFP) e de cinzas pesadas (CP) advindos de uma termoelétrica, em massa cerâmica na escala laboratorial. Foram realizados ensaios de caracterização físico-química e de classificação dos resíduos. Posteriormente foram desenvolvidas dez formulações através de planejamento experimental por delineamento de misturas simplex centroide, incorporando esses resíduos a uma massa padrão de cerâmica vermelha. Os corpos-de-prova foram conformados por extrusão sem vácuo e submetidos a tratamento térmico em estufa e queima em forno mufla a 900 °C. As propriedades tecnológicas avaliadas foram: retração térmica linear de secagem e de queima, absorção de água e resistência mecânica à compressão e por fim, foram realizados testes de eflorescência e análise fitotoxicológica. Os resultados de classificação dos resíduos, indicaram esses como não sendo perigoso – Classe II-B – inerte. Os testes físicos dos corpos-de-prova mostram que comparados a formulação base de cerâmica vermelha (STD), as demais formulações obtiveram resultados dentro dos parâmetros técnicos, que podem ser posteriormente realizados em um ensaio de escala industrial. Embora os ensaios mecânicos das provas com incorporação de resíduo ficaram abaixo da formulação base (STD), não se descarta uma prova em escala similar a industrial. No ensaio de eflorescência, observou-se que não houve presença de sais solúveis. E por fim, no ensaio fitotoxicológico, com Allium cepa L. de uma formulação com agregação de todas matérias-primas juntas, apresentou um resultado próximos ao padrão, se mostrando apto a reprodução em escala industrial. TFP (TFP CP (CP termoelétrica laboratorial físicoquímica físico química centroide corposdeprova corpos 90 C °C fim fitotoxicológica IIB II B inerte STD, STD , (STD) técnicos industrial observouse observou solúveis fitotoxicológico L matériasprimas matérias primas juntas 9 (STD

ABSTRACT Background: Despite optimized medical therapy, contemporary risk of surgery in inflammatory bowel diseases (IBD) after 10 years of diagnosis is 9.2% in patients with ulcerative colitis (UC) and 26.2% in Crohn’s disease, (CD) in the biological era. Objective: This consensus aims to detail guidance to the most appropriate surgical procedures in different IBD scenarios. In addition, it details surgical indications and perioperative management of adult patients with CD and UC. Methods: Our consensus was developed by colorectal surgeons and gastroenterologists representing the Brazilian Study Group of Inflammatory Bowel Diseases (GEDIIB), with the Rapid Review methodology being conducted to support the recommendations/statements. Surgical recommendations were structured and mapped according to the disease phenotypes, surgical indications, and techniques. After structuring the recommendations/statements, the modified Delphi Panel methodology was used to conduct the voting by experts in IBD surgery and gastroenterology. This consisted of three rounds: two using a personalized and anonymous online voting platform and one face-to-face presential meeting. Whenever participants did not agree with specific statements or recommendations, an option to outline possible reasons was offered to enable free-text responses and provide the opportunity for the experts to elaborate or explain disagreement. The consensus of recommendations/statements in each round was considered to have been reached if there was ≥80% agreement. Results and conclusion: This consensus addressed the most relevant information to guide the decision-making process for adequate surgical management of CD and UC. It synthesizes recommendations developed from evidence-based statements and state-of-art knowledge. Surgical recommendations were structured and mapped according to the different disease phenotypes, indications for surgery and perioperative management. Specific focus of our consensus was given to elective and emergency surgical procedures, determining when to indicate surgery and which procedures may be the more appropriate. The consensus is targeted to gastroenterologists and surgeons interested in the treatment and management of adult patients with CD or UC and supports decision-making of healthcare payors, institutional leaders, and/or administrators. Background therapy (IBD 1 92 9 2 9.2 (UC 262 26 26.2 Crohns Crohn s (CD era Objective scenarios addition Methods GEDIIB, GEDIIB , (GEDIIB) recommendationsstatements phenotypes techniques gastroenterology rounds facetoface face meeting freetext free text disagreement 80 ≥80 agreement conclusion decisionmaking decision making evidencebased evidence based stateofart state art knowledge payors leaders andor administrators 9. 26. (GEDIIB 8 ≥8 ≥

RESUMO Contexto: Apesar da terapia medicamentosa otimizada, o risco contemporâneo de cirurgia nas doenças inflamatórias intestinais (DII) após 10 anos do diagnóstico é de 9,2% em pacientes com retocolite ulcerativa (RCU) e de 26,2% na doença de Crohn (DC) na era biológica. Objetivo: Este consenso visa detalhar as orientações para os procedimentos cirúrgicos mais adequados em diferentes cenários da DII. Além disso, detalha as indicações cirúrgicas e o manejo perioperatório de pacientes adultos com DC e RCU. Métodos: Nosso consenso foi desenvolvido por cirurgiões colorretais e gastroenterologistas representantes da Organização Brasileira de Doença de Crohn e Colite (GEDIIB), com a metodologia de revisão rápida sendo conduzida para respaldar as recomendações. As recomendações cirúrgicas foram estruturadas e mapeadas de acordo com os fenótipos da doença, indicações cirúrgicas e técnicas. Após a estruturação das recomendações, a metodologia modificada do Painel Delphi foi utilizada para conduzir a votação por especialistas em cirurgia de DII e gastroenterologia. Esta consistiu em três rondas: duas com recurso a uma plataforma de votação online personalizada e anônima e uma reunião presencial. Sempre que os participantes não concordavam com afirmações ou recomendações específicas, era oferecida uma opção de delinear possíveis razões para permitir respostas em texto livre e dar a oportunidade para os especialistas elaborarem ou explicarem a discordância. O consenso de recomendações/declarações em cada rodada foi considerado alcançado se houve concordância ≥80%. Resultados e conclusão Este consenso abordou as informações mais relevantes para orientar o processo de tomada de decisão para o manejo cirúrgico adequado de DC e RCU. Ele sintetiza recomendações desenvolvidas a partir de evidências e conhecimento de alto nível. As recomendações cirúrgicas foram estruturadas e mapeadas de acordo com os diferentes fenótipos da doença, indicações para cirurgia e manejo perioperatório. O foco específico do nosso consenso foi dado aos procedimentos cirúrgicos eletivos e de emergência, determinando quando indicar a cirurgia e quais procedimentos podem ser os mais adequados. O consenso é direcionado a gastroenterologistas e cirurgiões interessados no tratamento e manejo de pacientes adultos com DC ou RCU e apoia a tomada de decisões de pagadores de saúde, líderes institucionais e/ou administradores. Contexto otimizada (DII 1 92 9 2 9,2 (RCU 262 26 26,2 (DC biológica Objetivo disso Métodos GEDIIB, GEDIIB , (GEDIIB) técnicas gastroenterologia rondas presencial específicas discordância recomendaçõesdeclarações declarações 80 ≥80% nível emergência saúde eou administradores 9, 26, (GEDIIB 8 ≥80 ≥8 ≥

Resumo podridão do colo e a fusariose causadas, respectivamente, pelos fungos de solo Fusarium solani e Fusarium oxysporum f. sp. passiflorae, estão entre os principais fatores que limitam o cultivo do maracujazeiro no Brasil. O presente trabalho teve como objetivo avaliar a resistência/suscetibilidade de espécies do gênero Passiflora aos patógenos de solo F. solani e F. oxysporum f. sp. passiflorae de diferentes biomas do Mato Grosso (Cerrado, Pantanal e Amazônia). Na Etapa I, avaliou a reação de P. edulis Sims, P. foetida, P. nitida e P. quadrangulares a oito isolados de F. solani. Na Etapa II, foram avaliados os genótipos P. edulis Sims, P. mucronata, P. foetida, P. nitida e P. morifolia a três isolados de F. oxysporum f. sp. passiflorae. O delineamento experimental foi em blocos casualizados em arranjo fatorial (genótipos x Isolados). As análises estatísticas utilizadas para ambas as etapas foram análise de variância pelo teste F e agrupamento de médias dos genótipos pelo teste de Scott-Knott (P=0,05). Para tal, foram utilizados os recursos computacionais do programa Genes. Entre os isolados de F. solani avaliados, foi constatada maior agressividade dos isolados FS8A e FS3P, indicando variabilidade genética entre os isolados. Os genótipos mais resistentes ao patógeno foram P. nitida e P. foetida. Dentre os isolados de F. oxysporum f. sp. passiflorae, não foi observado diferença significativa ao nível de agressividade, sendo as espécies P. mucronata e P. nitida mais resistentes à Fusariose. Assim, os genótipos P. nitida, P. foetida e P. mucronata podem ser indicados como fonte de resistência para programas de melhoramento do maracujazeiro comercial.

Abstract The stem rot and fusarium vascular wilt are among the main factors the most limiting the passion fruit cultivation in the State of Mato Grosso. This study aimed to evaluate the resistance / susceptibility of the genus Passiflora species to soil pathogens from different biomes of Mato Grosso (Cerrado, Pantanal and Amazon). The part I evaluated the response of P. edulis Sims, P. foetida, P. nitida and P. quadrangularis on eight isolates of F. solani. In part II was evaluated the genotypes P. edulis Sims, P. mucronata, P. foetida, P. nitida and P. morifolia on three isolates of F. oxysporum f. sp. passiflorae. The experimental design was randomized blocks in factorial arrangement (genotypes x isolates). The statistical analysis used for both steps were the variance analyses by F test and grouping of averages of genotypes by Scott-Knott test (P =0.05). Among the isolates of F. solani was found that isolates FS8A and FS3P are more aggressive, indicating genetic variability among isolates. The most resistant genotypes to the pathogen were P. nitidaand P. foetida. Among the isolates of F. oxysporum f. sp. passiflorae there was no significant difference in aggressive levels, and the P. mucronata and P. nitida species are more resistant to Fusarium. Thus genotypes P. nitida, foetida and P. mucronatacan be indicated as a resistance source to improvement of commercial passionfruit programs.

Abstract This study aims to develop a nano-sized fluoridated layered double hydroxide (LDH)-based release system via hydrothermal treatment for the controlled delivery of fluoride (F-) ions in the oral environment. The synthesis of conventional LDH-type (C-LDH) precursor nanomaterials was conducted using a co-precipitation method at constant pH, and the nanoparticulate-LDH (N-LDH) was synthesized by a hydrothermal procedure. Fluoride LDH (F-LDH) products were obtained through indirect synthesis using the precursor ion-exchange technique by varying the agitation time (2 and 24 h) and temperature (25 and 40 °C) to produce 12 material samples. The materials were characterized by energy dispersive x-ray, hexamethyldisilazane, digital radiography x-ray, Fourier-transform infrared, thermogravimetric analysis, and scanning electron microscopy. Additionally, the F-release kinetic profile was evaluated for 21 d in neutral and acid media with mathematical model analysis. Products with varying F-quantities were obtained, revealing specific release profiles. In general, there was a higher F-release in the acid medium, with emphasis on F-LDH-8. Fluoride-LDH and controlled fluoride delivery was successfully obtained, proving the potential of these nanomaterials as alternative anti-caries agents.

RESUMO A investigação das possíveis influências entre o treinamento de flexibilidade e o desempenho de força muscular pode contribuir para a compreensão do treinamento. O objetivo do presente estudo foi verificar o efeito de três semanas de treinamento de flexibilidade no torque e potência muscular. Dez adultos, divididos em Grupo Alongamento (GA, N=5) e Controle (GC, N=5) foram avaliados antes e após a intervenção. A intervenção foi realizada pelo GA e consistiu em um protocolo de alongamento estático passivo para os músculos posteriores da coxa, realizados em três por semana e durante três semanas. O torque e potência da extensão e flexão dos joelhos foram avaliados utilizando dinamômetro isocinético em três velocidades (60, 180 e 360º/s). A amplitude de movimento (ADM) foi avaliada pelo teste de sentar e alcançar. Houve incremento de ADM (pré: 23,0±5,6cm; pós: 30,1±6,58cm; p=0,033) do GA, mas não foram observadas diferenças entre e intra-grupos para as demais variáveis (p>0,05). Houveram correlações da ADM apenas para o torque da flexão (r=0,664; p=0,036) e potência da extensão (r=0,638; p=0,047) do joelho esquerdo a 60º/s. Conclui-se que três semanas de treinamento de flexibilidade com método estático passivo promoveu ganhos significativos de ADM, mas não possibilitou incrementos de torque e potência.

ABSTRACT Investigation about influences between stretching training and muscle strength performance can contribute to the understanding of training. The aim of the present study was to verify the effect of three weeks of stretching training on muscle torque and power. Ten adults, divided into Stretching Group (GA, N = 5) and Control Group (CG, N = 5) were evaluated pre and post intervention. The intervention was performed by GA and consisted of a passive static stretching protocol for the posterior thigh muscles, performed three times a week and during three weeks. The torque and power of the knee extension and flexion were evaluated using an isokinetic dynamometer at three speeds (60, 180 and 360º/s). Range of motion (ROM) was assessed using the sit and reach test. There was an increase in ROM (pre: 23.0 ± 5.6 cm; post: 30.1 ± 6.58 cm; p = 0.033) of GA, but there were no differences between and within groups for the other variables (p> 0.05). There were correlations of the ROM only for the flexion torque (r = 0.664; p = 0.036) and power of the extension (r = 0.638; p = 0.047) of the left knee at 60º/s. It was concluded that three weeks of static stretching training promoted significant gains in ROM, but did not allow increases in torque and power.

OBJECTIVE: To analyze the changes in the body composition of morbidly obese patients induced by a very low-calorie diet. METHODS: We evaluated 120 patients selected from a university hospital. Body composition was assessed before and after the diet provided during hospitalization, and changes in weight, body mass index, and neck, waist and hip circumferences were analyzed. Bioimpedance was used to obtain body fat and fat-free mass values. The data were categorized by gender, age, body mass index and diabetes diagnosis. RESULTS: The patients consumed the diet for 8 days. They presented a 5% weight loss (without significant difference among groups), which represented an 85% reduction in body fat. All changes in body circumference were statistically significant. There was greater weight loss and a greater reduction of body fat in men, but the elderly showed a significantly higher percentage of weight loss and greater reductions in body fat and fat-free mass. Greater reductions in body fat and fat-free mass were also observed in superobese patients. The changes in the diabetic participants did not differ significantly from those of the non-diabetic participants. CONCLUSIONS: The use of a VLCD before bariatric surgery led to a loss of weight at the expense of body fat over a short period, with no significant differences in the alteration of body composition according to gender, age, body mass index and diabetes status.

RESUMO Racional: Os níveis do antígeno carcinoembriônico no lavado peritoneal têm sido demonstrados como possível fator prognóstico de recidiva e mortalidade em pacientes com câncer gástrico. Objetivos: Medir seus níveis em lavado peritoneal durante operação de ressecção de câncer gástrico e ver se eles aumentados estão relacionados com mortalidade, recorrência, recidiva e outros fatores prognósticos. Métodos: Foi realizado lavado peritoneal durante ressecções de câncer gástrico; os níveis do antígeno carcinoembriônico nesse lavado maiores ou iguais a 210 ng/g foram considerados aumentados ou positivos. Resultados: Foram estudados 30 pacientes, destes, 33,33 % apresentaram níveis aumentados, os quais foram fator de risco para mortalidade em seis meses OR: 8,5 (1,458-49,539) IC 95%, mortalidade geral RR: 2,111 (1,314-3,391) IC 95%, mortalidade devido à doença OR: 12 (1,885-76,376) IC 95%, recorrência peritoneal OR: 9 (1,325-61,138) IC 95%, e recidiva ou progressão da doença OR: 27 (2,705-269,460) IC 95%. Conclusões: Os níveis aumentados do antígeno carcinoembriônico no lavado peritoneal foram fatores de risco para mortalidade, recorrência peritoneal, recidiva e progressão da doença em pacientes com câncer gástrico.

ABSTRACT Background: The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer. Aim: To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence, tumor relapse or other prognostic factors. Methods: In total, 30 patients (22 men, 8 women; median age 66 years) with resectable gastric cancer (mainly stage III and IV) were studied. Carcinoembryonic antigen level in peritoneal lavage was detected at operation by immunocytochemical method and a level over 210 ng/g of protein was considered as positive. Results: There were detected 10 positive cases (33.3%) of plCEA levels. These levels were associated with mortality, RR: 2.1 (p=0.018); peritoneal recurrence, OR: 9.0 (p=0.015); and relapse or gastric cancer progression, OR: 27.0 (p=0.001). Conclusion: Increased levels of plCEA fairly predicts mortality, peritoneal recurrence tumor relapse or cancer progression.

ABSTRACT CONTEXT AND OBJECTIVE: Patients undergoing the same neuromodulation protocol may present different responses. Computational models may help in understanding such differences. The aims of this study were, firstly, to compare the performance of aphasic patients in naming tasks before and after one session of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and sham, and analyze the results between these neuromodulation techniques; and secondly, through computational model on the cortex and surrounding tissues, to assess current flow distribution and responses among patients who received tDCS and presented different levels of results from naming tasks. DESIGN AND SETTING: Prospective, descriptive, qualitative and quantitative, double blind, randomized and placebo-controlled study conducted at Faculdade de Ciências Médicas da Santa Casa de São Paulo. METHODS: Patients with aphasia received one session of tDCS, TMS or sham stimulation. The time taken to name pictures and the response time were evaluated before and after neuromodulation. Selected patients from the first intervention underwent a computational model stimulation procedure that simulated tDCS. RESULTS: The results did not indicate any statistically significant differences from before to after the stimulation.The computational models showed different current flow distributions. CONCLUSIONS: The present study did not show any statistically significant difference between tDCS, TMS and sham stimulation regarding naming tasks. The patients’responses to the computational model showed different patterns of current distribution.

A correlação entre a composição química e os dados sensoriais de 28 amostras de cachaças foi investigada através de análise de componentes principais (PCA). Um modelo químico usando análise discriminante linear (LDA) para classificar as amostras de cachaças de acordo com suas qualidades sensoriais foi então elaborado. Este modelo apresentou habilidades preditivas de calibração e validação de 87,4 e 100%, respectivamente, e foi capaz de reconhecer corretamente 7 dentre 9 amostras adicionais, apresentando-se como uma ferramenta alternativa potencial para o reconhecimento das qualidades sensoriais de cachaças.

The correlation between the chemical composition and the sensory data for 28 cachaça samples was investigated using principal component analysis (PCA). A chemical model was then developed using linear discriminant analysis (LDA) to classify the distillate samples according to their sensory qualities. This model presented predictive abilities of calibration and validation of 87.4 and 100%, respectively, and was able to recognize correctly 7 out of 9 additional samples according to their sensory evaluations, showing itself as a potential alternative tool of recognizing cachaça sensory qualities.

As concentrações de 39 compostos orgânicos foram determinadas em três frações (cabeça, coração e cauda) obtidas da destilação em alambique do caldo de cana fermentado. Os resultados foram avaliados utilizando-se análise de variância (ANOVA), teste de Tukey, análise de componentes principais (PCA), agrupamento hierárquico (HCA) e análise discriminante linear (LDA). De acordo com PCA e HCA, os dados experimentais conduzem à formação de três agrupamentos. As frações de cabeça deram origem a um grupo mais definido. As frações coração e cauda apresentaram alguma sobreposição coerente com sua composição em ácidos. As habilidades preditivas de calibração e validação dos modelos gerados pela LDA para a classificação das três frações foram de 90,5 e 100%, respectivamente. Este modelo reconheceu como coração doze de treze cachaças comerciais (92,3%) com boas características sensoriais, apresentando potencial para a orientação do processo de cortes.

Concentrations of 39 organic compounds were determined in three fractions (head, heart and tail) obtained from the pot still distillation of fermented sugarcane juice. The results were evaluated using analysis of variance (ANOVA), Tukey's test, principal component analysis (PCA), hierarchical cluster analysis (HCA) and linear discriminant analysis (LDA). According to PCA and HCA, the experimental data lead to the formation of three clusters. The head fractions give rise to a more defined group. The heart and tail fractions showed some overlap consistent with its acid composition. The predictive ability of calibration and validation of the model generated by LDA for the three fractions classification were 90.5 and 100%, respectively. This model recognized as the heart twelve of the thirteen commercial cachaças (92.3%) with good sensory characteristics, thus showing potential for guiding the process of cuts.

Six wines were distilled in two different distillation apparatus (alembic and column) producing 24 distillates (6 for each alembic fraction - head, heart and tail; 6 column distillates). The chemical composition of distillates from the same wine was determined using chromatographic techniques. Analytical data were subjected to Principal Component Analysis (PCA) and Hierarchical Cluster Analysis (HCA) allowing discrimination of four clusters according to chemical profiles. Both distillation processes influenced the sugarcane spirits chemical quality since two types of distillates with different quantitative chemical profiles were produced after the elimination of fermentation step influence.

The concentration of 14 organic acids of 50 sugarcane spirits samples was determined by gas chromatography using flame ionization detection. The organic acids analytical quantitative profile in stills and column distilled spirits from wines obtained from the same must were compared. The comparison was also carried in "head", "heart" and "tail fractions of stills distilled spirits. The experimental data were analyzed by Principal Components Analysis (PCA) and pointed out that the distillation process (stills and column) strongly influences the lead spirits' organic acid composition and that producers' operational "cuts off" to produce "tail", "heart" and "head", fractions should be optimized.

OBJETIVO: Avaliar os efeitos da sepse abdominal sobre a formação de aderências e a cicatrização de anastomoses colônicas em ratos. MÉTODOS: 40 ratos distribuídos em dois grupos contendo 20 animais, para anastomose do cólon esquerdo na presença (grupo S) ou ausência (grupo N) de indução de sepse por ligadura e punção do ceco (CLP). Cada grupo foi dividido em subgrupos para eutanásia no terceiro (N3 e S3) ou sétimo (N7 e S7) dia de pós-operatório (DPO). Foi avaliada a quantidade de aderências e removido um segmento colônico contendo a anastomose para análise histopatológica, força de ruptura, hidroxiprolina e conteúdo de colágeno tecidual. RESULTADOS: Os animais submetidos à CLP apresentaram maior quantidade de aderências intra-abdominais tanto no 3° DPO (p=0,00) quanto no 7° DPO (p=0,00). Tiveram menores valores de força de ruptura no 3° DPO (p=0,00), porém maiores valores no 7° DPO (p=0,00). Não houve diferença na variação da concentração de hidroxiprolina, conteúdo de colágeno e histopatologia. CONCLUSÕES: A infecção peritoneal desencadeada por CLP aumentou a quantidade de aderências intra-cavitárias. Houve diminuição da resistência de anastomoses cólicas no 3° DPO, com posterior aumento no 7° DPO, sem efeito sobre os outros parâmetros da cicatrização.

PURPOSE: To evaluate the effects of abdominal sepsis on adhesion formation and colon anastomosis healing in rats. METHODS: Forty rats were distributed in two groups containing 20 rats each for left colon anastomosis in the presence (Group S) or absence (Group N) of induced sepsis by cecal ligation and puncture. Each group was divided into subgroups for euthanasia on the third (N3 and S3) or seventh (N7 or S7) post-operative day. The amount of adhesions was evaluated and a segment of the colon was removed for histopathologic analysis, bursting strength assessment, hydroxyproline and the determination of tissue collagen. RESULTS: The subjects which underwent cecal ligation and puncture presented a higher amount of intra-abdominal adherences in both third (p=0,00) and seventh (p=0,00) post-operatory days. Smaller bursting strengths were found in the S3 subgroup, and greater bursting strengths were found in the S7 subgroup. There was no difference in the variations on the concentrations of hydroxyproline, tissue collagen and histopathology. CONCLUSIONS: The peritoneal infection which was developed by cecal ligation and puncture raised the amount of intra-cavitary adhesions. There was a decrease in the amount of colonic anastomosis on the third post-operatory day with a following raise on the seventh without any effects on other healing parameters.