ABSTRACT Purpose To investigate verb fluency performance in individuals with Alzheimer’s disease compared with healthy older adults by analyzing total correct responses, number of clusters, average cluster size, and number of switches. Methods This is a case-control study of 39 healthy older adults and 29 older adults with a diagnosis of Alzheimer’s disease. Verb fluency performance was analyzed in terms of total number of correct verbs retrieved, number of clusters, average cluster size, and number of switches. To obtain the study outcomes, we previously conducted a procedure for categorization of the verbs that would compose the clusters. The classification of verbs was adapted for this study, including assessment by raters and analysis of inter-rater reliability. Results Individuals with Alzheimer’s disease showed significantly poorer performance than healthy controls in the number of switches and total number of correct verbs retrieved. The two groups did not differ significantly in the other measures. Conclusion In this study, individuals with Alzheimer’s disease showed impaired verb fluency, characterized by a reduced number of verbs retrieved and fewer transitions between verb categories. The findings suggest that, in Alzheimer’s disease, verb fluency is more sensitive to cognitive deficits resulting from executive dysfunction than from semantic disruption. Alzheimers Alzheimer s responses clusters size casecontrol case control 3 2 outcomes interrater inter rater reliability measures categories disruption

RESUMO Objetivo Investigar o desempenho na tarefa de fluência de verbos de pessoas com doença de Alzheimer em comparação à idosos saudáveis, a partir da análise do número total de palavras corretas evocadas, do número de clusters, do tamanho médio dos clusters e do número de switches. Método Este é um estudo de caso-controle no qual participaram 39 idosos saudáveis e 29 participantes com diagnóstico de doença de Alzheimer. O desempenho da fluência de verbos dos participantes foi analisado quanto ao total de verbos gerados corretamente, número de clusters, tamanho médio dos clusters e número de switches. Para a obtenção dos desfechos do estudo foi realizado um processo prévio de definição das categorias de verbos que constituiriam clusters. A classificação dos verbos foi adaptada para a este estudo, incluindo a análise de juízes com investigação do índice de concordância. Resultados Dentre as variáveis de interesse comparadas entre os grupos estudados, houve um desempenho estatisticamente inferior no grupo de pessoas com doença de Alzheimer quanto ao número de switches e total de verbos gerados corretamente. Nas demais medidas, os grupos foram semelhantes. Conclusão Neste estudo pessoas com doença de Alzheimer apresentaram déficit no desempenho da tarefa de fluência verbal de verbos, caracterizado por uma redução do número total de verbos gerados e uma menor variabilidade de categorias de verbos. Os achados sugerem que, na doença de Alzheimer, a fluência de verbos é mais sensível aos déficits cognitivos decorrentes de disfunção executiva do que aos déficits semânticos. evocadas casocontrole caso controle 3 2 corretamente concordância estudados medidas semelhantes semânticos

Abstract The coronavirus disease 2019 (COVID-19) mortality rates varied among the states of Brazil during the course of the pandemics. The human leukocyte antigen (HLA) is a critical component of the antigen presentation pathway. Individuals with different HLA genotypes may trigger different immune responses against pathogens, which could culminate in different COVID-19 responses. HLA genotypes are variable, especially in the highly admixed Brazilian population. In this ecological study, we aimed to investigate the correlation between HLA haplotypes and the different regional distribution of COVID-19 mortality in Brazil. HLA data was obtained from 4,148,713 individuals registered in The Brazilian Voluntary Bone Marrow Donors Registry. COVID-19 data was retrieved from epidemiological bulletins issued by State Health Secretariats via Brazil’s Ministry of Health from February/2020 to July/2022. We found a positive significant correlation between the HLA-A*01~B*08~DRB1*03 haplotype and COVID-19 mortality rates when we analyzed data from 26 states and the Federal District. This result indicates that the HLA-A*01~B*08~DRB1*03 haplotype may represent an additional risk factor for dying due to COVID-19. This haplotype should be further studied in other populations for a better understanding of the variation in COVID-19 outcomes across the world. 201 COVID19 COVID 19 (COVID-19 pandemics (HLA pathway pathogens COVID-1 variable population study 4148713 4 148 713 4,148,71 Registry Brazils s February2020 February 2020 February/202 July2022 July 2022 July/2022 HLAA*01~B*08~DRB1*03 HLAA01B08DRB103 HLAABDRB A*01~B*08~DRB1*03 A 01 B 08 DRB1 03 DRB HLA-A*01~B*08~DRB1*0 2 District COVID19. 19. world 20 COVID1 1 (COVID-1 COVID- 414871 14 71 4,148,7 February202 202 February/20 July202 July/202 HLAA HLAA*01~B*08~DRB1*0 HLAA01B08DRB10 A01B08DRB103 ABDRB A*01~B*08~DRB1*0 0 HLA-A*01~B*08~DRB1* (COVID- 41487 7 4,148, February20 February/2 July20 July/20 HLAA*01~B*08~DRB1* HLAA01B08DRB1 A01B08DRB10 A*01~B*08~DRB1* HLA-A*01~B*08~DRB1 (COVID 4148 4,148 February2 February/ July2 July/2 HLAA*01~B*08~DRB1 HLAA01B08DRB A01B08DRB1 A*01~B*08~DRB1 HLA-A*01~B*08~DRB 414 4,14 July/ HLAA*01~B*08~DRB A01B08DRB A*01~B*08~DRB 41 4,1 4,

Abstract The iAtlantic Project has established an international collaborative strategy to improve mapping and characterization of deep and open ocean ecosystems in understudied regions of the Atlantic and evaluate their health. In December 2022, the first iAtlantic expedition in the South Atlantic set off to map and explore seafloor ecosystems in the Santos Basin slope (200-1,000 m depths) in collaboration with the Petrobras ‘Santos Basin - Regional Characterization Project.’ The 17-day ‘iAtlantic_BR10-Petrobras’ cruise was conducted on board the research vessel NPqHOc Vital de Oliveira (Brazilian Navy) and performed (a) water column structure characterization, (b) seafloor morphology mapping, (c) description of benthic habitats and communities by seafloor imagery and biological/ geological sampling, and (d) ex-situ experiments to assess the functioning of sedimentary ecosystems and their responses to climate-related environmental changes. This study describes the rationale behind the iAtlantic_BR10-Petrobras cruise science plan, reports its sampling strategy and methods, and summarizes its collected data and preliminary results. health 2022 2001,000 2001000 200 1,000 1 000 (200-1,00 depths Project. 17day day 17 ‘iAtlantic_BR10Petrobras iAtlanticBR10Petrobras iAtlanticBRPetrobras ‘iAtlantic_BR10 BR10 BR ‘iAtlantic_BR10-Petrobras Brazilian Navy a (a b (b c (c biological d (d exsitu ex situ climaterelated climate related changes iAtlantic_BR10Petrobras iAtlantic_BR10 plan methods results 202 2001 2001,00 200100 20 1000 1,00 00 (200-1,0 BR10Petrobras iAtlanticBR iAtlanticBR10 ‘iAtlantic_BR1 BR1 iAtlantic_BR1 2001,0 20010 2 100 1,0 0 (200-1, BRPetrobras iAtlanticBR1 ‘iAtlantic_BR iAtlantic_BR 2001, 10 1, (200-1 (200- (200 (20 (2 (

Abstract Paper aims This paper presents the literature findings of the Covid-19 vaccines supply chain, its main challenges and best practices, which are compared and verified empirically. Originality The questionnaire developed in this study provides new empirical data about the Covid-19 vaccines supply chain, especially regarding the impacts of the Covid-19 pandemic in the chain, as these events are still recent. Research method A questionnaire was sent by e-mail to specialists working with the Covid-19 vaccine supply chain in South America. Each response was compared to the literature findings. Main findings Despite the challenges faced by vaccination programs, some countries have achieved good results due to strategies adopted at the beginning of their immunization campaigns. The empirical research confirmed that literature findings match business reality, although some empirical results vary depending on the scenario of the country regarding the impacts of the pandemic. Implications for theory and practice This paper summarizes the Covid-19 vaccine supply chain and its challenges, best practices of the most successful countries regarding the immunization process, providing a better understanding of the pandemic scenario. Some empirical data corroborate the literature, and some discrepancies allow the formulation of suppositions that may be tested in future studies. Covid19 Covid 19 Covid-1 empirically recent email e mail America programs campaigns reality process studies Covid1 1 Covid-