Abstract Depression plays an important role in non-adherence to medical recommendations. Fluoxetine is a first line of depression treatment. This study aimed to evaluate adherence to drug therapy in fluoxetine users by different methods. A cross-section study was conducted with 53 depressed patients on fluoxetine for at least six months. Drug therapy adherence was assessed by validated questionnaires [Brief Medication Questionnaire (BMQ) and Morisky-Green test (MG)] and by the blood concentration of fluoxetine and its active metabolite norfluoxetine. Blood samples were taken before the daily first dose of fluoxetine. The plasmatic concentration of fluoxetine and norfluoxetine indicated that 58.5% volunteers were within the recommended therapeutic range and thus considered adherent to drug therapy. However, questionnaires indicated a non-adherent majority: 41.5% patients had a high degree of adherence in MG and only 13.2% were adherent to pharmacological treatment in BMQ. Most fluoxetine users showed a plasma concentration of fluoxetine and norfluoxetine within the therapeutic range, despite the low adherence to the drug therapy evaluated by the questionnaires. Thus, we suggest that plasma levels of fluoxetine and norfluoxetine could be used as the main method to check adherence to treatment. nonadherence non recommendations methods crosssection cross section 5 months Brief BMQ (BMQ MoriskyGreen Morisky Green (MG) 585 58 58.5 However nonadherent majority 415 41 41.5 132 13 2 13.2 Thus (MG 58. 4 41. 1 13.

Resumo Pirênios de Ilex parguariensis, popularmente conhecida como erva-mate, foram classificados como dormentes. O objetivo deste estudo foi investigar as causas da dormência dos pirênios de Ilex paraguariensis. Para isso, foram realizados os seguintes testes: a) Dormência física: taxa de absorção em água e em azul de metileno; detecção de lignina e compostos lipofílicos no endocarpo e tegumento; b) Dormência fisiológica: bioensaios em sementes de alface, detecção e quantificação de compostos fenólicos; c) Dormência morfológica: análise embrionária. Para a taxa de absorção, observou-se um aumento na massa dos pirênios, porém, quando a embebição foi realizada em azul de metileno, a absorção ocorreu apenas no endocarpo. A lignina também foi observada na forma de uma camada de esclerênquima próxima ao tegumento da semente. Semelhantemente compostos lipofílicos foram observados em uma camada externa ao endosperma. Os bioensaios com sementes de alface indicaram a presença de inibidores químicos. Na avaliação morfológica dos pirênios, apenas 55,5% dos embriões foram visualizados e estavam nos estágios globular ou coração. Pirênios de Ilex paraguariensis possuem dormência combinada: física (não há absorção de água), morfológica (devido ao subdesenvolvimento do embrião) e há evidências de dormência fisiológica (presença de inibidores); Contudo, recomenda-se investigar os agentes inibidores.

Abstract Ilex parguariensis pyrenes, popularly known as “yerba mate”, were classified as dormant. This study aim to investigated the causes of dormancy in Ilex paraguariensis’ pyrenes. Hence, the following tests were performed: a) Physical dormancy: rate of absorption in water and methylene blue; detection of lignin and lipophilic compounds in the endocarp and integument; b) Physiological dormancy: bioassays in lettuce seeds, detection, and quantification of phenolic compounds; c) Morphological dormancy: embryo analysis. For the absorption rate, an increase was observed in the mass of the pyrenes, however, when imbibition was performed in methylene blue, absorption only occurred in the endocarp. Lignin was also observed in the form of a sclerenchyma layer next to the seed coat. Similarly, lipophilic compounds were observed in a layer, external to the endosperm. The bioassays with lettuce seeds indicated the presence of chemical inhibitors. In the morphological evaluation of the pyrenes, only 55.5% of the embryos were visualized and they were in the globular or heart stages. Ilex paraguariensis pyrenes have combined dormancy: physical (not water absorption), morphological (due to the underdeveloped embryo), and there are shreds of evidence about physiological dormancy (presence of inhibitors); however, it is recommended to investigate the inhibitory agent.

Abstract This study sought to determine the possible causes of the low seed quality of I. paraguariensis A. St. Hil. Seeds from six samples collected at different sites were classified as empty, decayed, herbivorous and full. Viability was assessed by tetrazolium test in seeds filled with a visualized embryo. High amounts of empty and deteriorated seeds (54% to 93%) were verified in four of the evaluated samples, and insect attack was observed in two samples. The viability of visualized embryo-filled seeds was 83% to 100%. Low quality generally results from the presence of empty and deteriorated seeds, as well as dormancy.

RESUMO:O presente artigo propõe pensar sobre o processo de individuação na formação de professores, aprofundando o olhar nos processos que permeiam a formação docente, muitas vezes legitimada por modos de ser que delimitam uma "forma". Utilizamos, principalmente, o diálogo teórico entre o escritor Mia Couto e o filósofo Gilbert Simondon, para trazer à tona a operação de individuação que lida com outros tempos e espaços formativos. A individuação que conversa com a literatura nos permite perceber a processualidade do vivo, em seu caráter de inacabamento, e das nossas individuações infinitas, efetuadas pelo afetivo. Mia Couto, através da sua escrita literária, ilustra a não-identidade de Simondon e de como acessamos o mundo (e somos acessados por ele) quando nos desvencilhamos de modos de ser definidos e determinados. Assim, desconstruimos o indivíduo tomado como entidade acabada e fazemos aparecer o sujeito em co-existência com o mundo.

ABSTRACT:This article proposes to reflect upon the process of individuation in teacher education, broadening the view on processes which permeate teacher training, often legitimized by ways of being that delimit a "form". This reflection is mainly based on the theoretical dialogue between the writer Mia Couto and the philosopher Gilbert Simondon, aiming to highlight the operation of individuation that deals with other times and formative spaces. Observing individuation through dialoguing with literature allows us to realize the processuality of the living subject, in their character of incompleteness, and of our endless individuations, performed by the affective domain. Mia Couto, through his literary writings, illustrates the non-identity of Simondon and how we access the world (and are accessed by it) when we get rid of defined and determined ways of being. Thus, we deconstruct the individual that is taken as a finished entity and provoke the emergence of the subject in co-existence with the world.

RÉSUMÉ:Cet article propose à réfléchir sur le processus d'individuation dans la formation d'enseignants, en approfondissant le regard sur les processus qui traverse cette formation, souvent légitimée par des manières d'être qui délimitent une "forme". On a utilisé principalement le dialogue théorique entre l'écrivain Mia Couto et le philosophe Gilbert Simondon pour mettre en évidence l'opération d'individuation qui travaille avec d'autres temps et espaces formatifs. L'individuation qui dialogue avec la littérature permet de comprendre la processualité du "vivant", dans son caractère d'inachèvement et de nos individuations infinies, réalisées par l'affectif. Mia Couto, par son écriture littéraire, illustre la non-identité de Simondon et de comment on accède au monde (et comment on est accédé par lui) quand on se débarrasse de manières d'être définies et déterminées. Ainsi, on déconstruit l'individu pris comme entité finie et on fait apparaître le sujet celui qui coexiste avec le monde.