RESUMEN Introducción: La rápida transmisión y los síntomas graves asociados con la infección aguda por el virus de la chikungunya (CHIKV) en niños lo convierten en un problema de salud altamente preocupante. Objetivo: Este estudio tuvo como objetivo describir las características de la infección aguda por el virus de la chikungunya en niños del Departamento de Caaguazú, Paraguay. Materiales y métodos: Un estudio retrospectivo fue realizado en el Departamento de Caaguazú, Paraguay, en 2023, con todos los pacientes que acudieron al Hospital Regional dentro de los 5 días posteriores al desarrollo de síntomas característicos de la infección aguda por CHIKV y que dieron positivo para el virus mediante RT-PCR. Pacientes con infecciones por Dengue o Zika fueron excluidos. Se recogieron datos sobre las características clínicas mediante un formulario normalizado de registro de casos y se creó un conjunto de datos electrónicos para su análisis. Resultados: Se incluyeron en el estudio un total de 461 niños. 51,6% eran mujeres. Los casos se dividieron en grupos según la edad pediátrica: lactantes (0-23 meses, n=88, 19,1 %), preescolares (2-5 años, n=115, 24,9%), escolares (6-11 años, n=163, 35.4%), and adolescentes (12-17 años and 11 meses, n=95, 20.6 %). La mialgia (64,6%) y la artralgia (63.7%) fueron más prevalentes en escolares y adolescentes. El vómito (89%), la cefalea (89,4%) y el dolor retroorbitario (95%) fueron más comunes en preescolares, escolares y adolescentes, mientras que la erupción cutánea (39,5%) y las petequias (18,5%) fueron más prevalentes en lactantes. Cuatro niños fallecieron durante el período de estudio. Conclusión: La epidemia de virus de la CHIKV de 2023 en Paraguay tuvo diferentes presentaciones clínicas dependiendo de la edad de los niños afectados, con resultados fatales ocurriendo en un pequeño porcentaje de casos.

ABSTRACT Introduction: The rapid transmission and severe symptoms associated with acute chikungunya virus (CHIKV) infection in children make it a highly concerning health issue. Objective: This study aimed to describe the characteristics of acute chikungunya virus infection in children from the Department of Caaguazú, Paraguay. Material and Methods: A retrospective observational study was conducted in the Department of Caaguazú, Paraguay, in 2023, with all patients who came to the Regional Hospital within 5 days of developing characteristic symptoms of acute CHIKV infection and tested positive for the virus by RT-PCR. Patients with Dengue or Zika infections were excluded. We collected data on clinical characteristics using a standardized case record form and created an electronic dataset for analysis. Results: A total of 461 children were included in the study. 51.6% were women. Cases were divided into groups based on pediatric age: infants (0-23 months, n=88, 19.1%), preschoolers (2-5 years, n=115, 24.9%), schoolchildren (6-11 years, n=163, 35.4%), and adolescents (12-17 years and 11 months, n=95, 20.6%). Schoolchildren and adolescents experienced a higher prevalence of myalgia (64.6%) and arthralgia (63.7%). Vomiting (89%), headache (89.4%), and retro-orbital pain (95%) were more common in preschoolers, schoolchildren, and adolescents, while rash (39.5%) and petechiae (18.5%) were more prevalent in infants. Four children died during the study period. Conclusion: The 2023 CHIKV virus epidemic in Paraguay had different clinical presentations depending on the age of the affected children, with fatal outcomes occurring in a small percentage of cases.

Abstract Background: Climate change is becoming more evident, and distribution models are useful tools to predict the effect it might cause on biodiversity. Hypotheses: Under climate change scenarios, temperate forests species of the genus Pinus and Quercus will undergo reductions in their distribution area and changes in their spatial pattern. Studied species: Arbutus xalapensis, Clethra mexicana, Pinus devoniana, Pinus oocarpa, Pinus teocote, Quercus acutifolia, Quercus castanea, Quercus crassifolia, Quercus elliptica, Quercus magnoliifolia and Quercus rugosa. Study site: Oaxaca Methods: Two scenarios were constructed, an optimistic one (SSP-1 and RCP 2-6) and a pessimistic one (SSP-5 and RCP 8.5) for the years 2030 and 2090. A total of 1,383 records and eight bioclimatic variables were used, along with seven learning algorithms, evaluated using ROC and TSS metrics. Results: An ensemble model was obtained, in which the most important contributing variables were precipitation of the wettest quarter, mean annual temperature, minimum temperature of the coldest month and annual temperature range. The species that showed the highest ROC values were Clethra mexicana (0.91) and Arbutus xalapensis (0.89) with TSS values of 0.68 and 0.60, respectively. Conclusions: Regardless of the scenario, by the year 2090 all species of Pinus and Quercus will reduce their potential distribution. Therefore, it is urgent to establish conservation policies.

Resumen: Antecedentes: El cambio climático es cada vez más evidente y los modelos de distribución son herramientas que permiten predecir el efecto que este podría causar en la biodiversidad. Hipótesis: Ante escenarios de cambio climático, las especies de bosques templados de los géneros Pinus y Quercus presentarán reducciones en su área de distribución y cambios en su patrón espacial. Especies de estudio: Arbutus xalapensis, Clethra mexicana, Pinus devoniana, Pinus oocarpa, Pinus teocote, Quercus acutifolia, Quercus castanea, Quercus crassifolia, Quercus elliptica, Quercus magnoliifolia y Quercus rugosa. Sitio de estudio: Oaxaca. Métodos: Se construyeron dos escenarios, optimista (SSP-1 y RCP 2-6) y pesimista (SSP-5 y RCP 8.5) a los años 2030 y 2090. Se utilizaron 1,383 registros y ocho variables bioclimáticas en conjunto con siete algoritmos de aprendizaje evaluados mediante las métricas ROC y TSS. Resultados: Se obtuvo un modelo de conjunto en el cual las variables que más contribuyeron fueron la precipitación del trimestre más húmedo, la temperatura media anual, la temperatura mínima del mes más frío y el rango de temperatura anual. Las especies que mostraron mayor valor de ROC fueron Clethra mexicana (0.91) y Arbutus xalapensis (0.89) con los valores de TSS de 0.68 y 0.60, respectivamente. Conclusiones: Sin importar el escenario, para el año 2090 todas las especies de Pinus y Quercus reducirán su distribución potencial, por lo que es urgente establecer políticas de conservación.

ABSTRACT Introduction. Chikungunya virus (CHIKV) infection typically presents as an acute febrile illness that is self-limiting and predominantly characterized by severe polyarthralgia and myalgia. Objective. The purpose of this study was to describe the clinical characteristics of acute chikungunya virus infection in an adult population. Materials and Methods. This was a descriptive, cross-sectional, observational study. The study population included adults from a specific region of Paraguay during the CHIKV epidemic in 2022-2023. Inclusion criteria encompassed all patients who presented to the hospital within five days after developing typical symptoms of acute CHIKV infection, confirmed by RT-PCR, and after excluding the presence of dengue and Zika. Results. A total of 803 adults were included, with an average age of 45.13 ± 18.63 years and a male/female ratio of 1:1.79. At epidemiological weeks 8, 10, 11, 78, 120, and 132 cases were documented, respectively. The most common clinical manifestations were fever in 97% of the cases (n=583), arthralgia and arthritis in 86.03% (n=653), myalgias in 77.08% (n=585), and headache in 73.91% (n=561). There were 6 deaths (0.75% of the total cases). Conclusion. The clinical presentation of CHIKV during the 2023 epidemic in Paraguay is consistent with previous descriptions in other regions. The disease generated a significant number of medical consultations and led to saturation of the public health system, which was fatal in a small percentage of cases.

RESUMEN Introducción. La infección por el virus del Chikunguña (CHIKV) se presenta típicamente como una enfermedad febril aguda que es autolimitada y se caracteriza predominantemente por poliartralgia y mialgias graves. Objetivo. el propósito de este estudio fue describir las características clínicas de la infección aguda por el virus del Chikunguña en una población adulta. Materiales y Método. Este fue un estudio observacional, descriptivo y transversal. La población de estudio incluyó adultos de una región específica de Paraguay durante la epidemia de CHIKV en 2022-2023. Los criterios de inclusión abarcaron a todos los pacientes que se presentaron el Hospital Regional dentro de los cinco días posteriores al desarrollo de síntomas típicos de CHIKV, confirmados por RT-PCR, y tras excluir dengue y Zika. Resultados. Se incluyeron un total de 803 adultos, con una edad media de 45,13 ± 18.63 años y una proporción de género masculino/femenino de 1:1.79. En las semanas epidemiológicas 8, 10 y 11 se documentaron 78, 120 y 132 casos, respectivamente. Las manifestaciones clínicas más comunes fueron fiebre en el 97% de los casos (n=583), artralgia y artritis en el 86,03% (n=653), mialgias en el 77,08% (n=585) y cefalea en el 73,91% (n=561). Hubo 6 muertes (0,75% del total de casos). Conclusión. La presentación clínica de CHIKV durante la epidemia 2023 en Paraguay es consistente con descripciones previas en otras regiones. La enfermedad generó un número significativo de consultas médicas y llevó a la saturación del sistema de salud pública, siendo fatal en un pequeño porcentaje de casos.

Abstract Sperm routinary fitness evaluation is not sufficient to predict bull reproductive capacity as they present differences in fertility up to 40%. Among the defects which compromise spermatozoa functionality, new approaches consider the study of sperm chromatin, which is the core structure containing paternal genetic information. Sperm chromatin needs to be compacted to maintain the integrity of DNA, which occurs by binding nucleoproteins with high affinity to DNA. In the last stages of sperm maturation, chromatin is hyper-compacted by basic proteins called protamines in a process named protamination. In this review, we summarized intrinsic and extrinsic factors that are suggested to influence protamination in bull spermatozoa, considering old and new evidence from human and murine spermatozoa. Also, the current approaches to evaluate bull protamination and its relationship with fertility were described. Nevertheless, the physiological mechanisms of protamination are still poorly understood.

RESUMO. Testes de fluência verbal são procedimentos amplamente utilizados na avaliação neuropsicológica. A análise da performance de pessoas com afasia no teste de fluência verbal fonêmica (FVF), do ponto de vista quantitativo e qualitativo, pode contribuir para uma melhor compreensão das mudanças cognitivas que ocorrem nesse grupo de pacientes. Objetivo: Os objetivos deste estudo foram analisar as medidas de estratégias de agrupamento e de mudança de agrupamento na FVF de pessoas com afasia e investigar a correlação entre o uso dessas estratégias, o desempenho quantitativo no teste e o desempenho em funções executivas. Métodos: Foi realizado um estudo transversal com 15 pessoas com afasia, destros, falantes nativos do português brasileiro, com idade entre 19 e 92 anos. Eles foram submetidos ao teste F-A-S e ao Teste do Relógio (TDR). Foram obtidas as seguintes medidas no F-A-S: escore total, número e tamanho médio de agrupamento e número de mudança de agrupamento. Para análise de correlação foi utilizado o teste de Spearman. Resultados: Foi verificada correlação positiva entre todos os escores do teste F-A-S, variando entre p=0,61 (p<0,001) e p=0,91 (p<0,001). Não foram encontradas correlações entre tais medidas e o escore no TDR (p≤0,31; p≥0,260). Conclusões: A análise quantitativa e qualitativa do F-A-S de pessoas com afasia, mesmo com diferentes manifestações linguísticas, mostrou que elas apresentam escores inferiores e o número total de palavras e o número de mudanças de agrupamento possuem forte correlação. Não foi observada correlação entre funções executivas, avaliada pelo TDR, e o desempenho na medida de mudança de agrupamento.

ABSTRACT. Verbal fluency tests are widely used in neuropsychological assessment. The quantitative and qualitative analysis of the performance of aphasic individuals on the phonemic verbal fluency (PVF) test can contribute to a better understanding of cognitive changes in this group of patients. Objective: This study aimed to analyze clustering and switching measures of PVF in people with aphasia and investigate the relationship between the use of these strategies, the quantitative performance on the test, and the performance on executive functions. Methods: This is a cross-sectional study of 15 people with aphasia, right-handed, native speakers of Brazilian Portuguese, aged 19 to 92 years. They were submitted to the F-A-S test and the Clock Drawing Test (CDT). The following measures were obtained in the F-A-S test: total score, number of clusters, mean cluster size, and number of switches. Spearman's test was used to analyze correlation. Results: We found a positive correlation among all F-A-S test scores, ranging from p=0.61 (p<0.001) to p=0.91 (p<0.001). No correlation was identified between these measures and CDT performance (p≤0.31; p≥0.260). Conclusions: The quantitative and qualitative analysis of F-A-S in people with aphasia, even those with different linguistic manifestations, showed that these individuals presented lower scores and that the number of total words and the number of switches were strongly correlated. We found no correlation between executive function, assessed by the CDT, and switching performance on the F-A-S test.

Abstract Neuropathic pain is an entity that causes patient disability and its diagnosis and treatment is a challenge for physicians. In a significant percentage of patients with neuropathic pain, it is restricted to one dermatome or to a particular region of the body; in this case, it is referred to as localized neuropathic pain. There are no Mexican clinical guidelines proposing recommendations for the diagnosis and treatment of localized neuropathic pain in our population. This article presents the recommendations of a multidisciplinary consensus of specialists from different areas involved in the diagnosis and treatment of this type of patients.

Resumen El dolor neuropático es una entidad que provoca discapacidad al paciente y su diagnóstico y tratamiento es un reto para los médicos. En un porcentaje importante de pacientes afectados, el dolor neuropático se presenta circunscrito a un dermatoma o a una región concreta del cuerpo, denominándose en ese caso dolor neuropático localizado. No existen guías clínicas mexicanas que postulen recomendaciones para el diagnóstico y tratamiento del dolor neuropático localizado en nuestra población. En este artículo se exponen las recomendaciones de un consenso multidisciplinario realizado con especialistas de distintas áreas implicadas en el diagnóstico y tratamiento de este tipo de pacientes.

No estudo da Física a utilização de produtos tecnológicos gera novas formas de conhecimento e agem como um facilitador na superação de dificuldades de aprendizagem dos estudantes. Todavia, para o sucesso do uso de ferramentas tecnológicas nesse processo, faz-se necessário que os professores tenham conhecimentos e se apropriem dessas tecnologias. O presente artigo apresenta os resultados de um trabalho desenvolvido junto aos professores que atuam no ensino de Física nos onze municípios pertencentes Í área de abrangência da 32Âê Coordenadoria Regional de Educação (32Âê CRE). Nele, procurou-se averiguar as dificuldades enfrentadas por eles para a utilização das Tecnologias da Informação e Comunicação (TIC) em sala de aula e oferecemos um minicurso em que exploramos as potencialidades do software Tracker para o ensino da Física no ensino médio. O objetivo proposto foi atingido, pois a formação continuada despertou nos professores a vontade de utilização do Tracker em suas aulas e também gerou um material auxiliar para o estudo do Tracker servindo como um suporte técnico/pedagógico na sua utilização.

In the study of physics the use of technological products generates new forms of knowledge and acts as a facilitator in overcoming students' learning difficulties. However, for the success of the use of technological tools in this process, it is necessary that teachers have knowledge and take possession of such technologies. The present article presents the results of a work developed with teachers who work in physics teaching in the eleven cities belonging to the 32nd Regional Education Coordination area (32nd CRE). In it, we tried to find out the difficulties they faced in using Information and Communication Technologies (ICT) in the classroom and offered a mini-course where we explored the potential of Tracker software on Physics teaching in high school. The proposed objective was reached because the continuous training aroused - in teachers - the willingness to use Tracker in their classes and also generated an auxiliary material for the study of Tracker serving as a technical / pedagogical support in its own use.

Abstract: The estimation and mapping of aboveground biomass over large areas can be done using the remote sensing tools. The objective of this study was to estimate the aboveground biomass of two types of tropical forest: semi-evergreen (SETF) and semi-deciduous tropical forest (SDTF) in the Yucatan Peninsula, Mexico, using metrics obtained from LiDAR (Light Detection and Ranging) data. Data from 365 plots of the National Forest and Soils Inventory of Mexico were used to calibrate aboveground biomass models using multiple linear regression and Random Forest. These models were used for mapping aboveground biomass along LiDAR strips. The transformed regression model explained the variance by 62% (RMSE = 41.44 Mg ha-1 for SETF & 36.60 Mg ha-1 for SDTF) for both types of vegetation. The models of Random Forest explained the variance by 57% (RMSE = 40.73 Mg ha-1) for SETF and only 52% (RMSE = 35.10 Mg ha-1) by SDTF. The mismatch between the field data and LiDAR data, as well as the error in the precision of the coordinates of the inventory plots, were recognized as factors that influenced on the results. Despite the above, the estimates obtained could serve as a basis to estimate the complete biomass inventory in the study area by incorporating spectral data derived from a remote sensor that covers the entire area.

Resumen: La estimación y el mapeo de la biomasa aérea sobre áreas extensas puede realizarse haciendo uso de las herramientas que ofrece la percepción remota. El objetivo de este estudio fue estimar la biomasa aérea de dos tipos de selva mediana: subperennifolia (SMSP) y subcaducifolia (SMSC) en la península de Yucatán, México, empleando métricas generadas a partir de datos Light Detection and Ranging (LiDAR). Se usaron datos de 365 unidades de muestreo del Inventario Nacional Forestal y de Suelos (INFyS) de México para calibrar modelos de biomasa aérea usando regresión lineal múltiple y Random Forest (RF). Con estos modelos se mapeó la biomasa aérea sobre franjas de datos LiDAR. El modelo de regresión transformado logró explicar la varianza en un 62% (RMSE = 41.44 Mg ha-1 para SMSP y 36.60 Mg ha-1 para SMSC) para ambos tipos de vegetación. Los modelos generados a través de RF lograron explicar la varianza en un 57% (RMSE = 40.73 Mg ha-1) para la SMSP y solo de 52% (RMSE = 35.10 Mg Ha-1) para la SMSC. El desfase entre la toma de datos en campo y LiDAR, así como el error en la precisión de las coordenadas de los sitios de inventario, son factores reconocidos que influyeron en los resultados. A pesar de lo anterior, las estimaciones obtenidas podrían servir de base para estimar el inventario completo de biomasa en el área de estudio incorporando datos espectrales derivados de un sensor remoto que cubra la totalidad de esta.

Resumo: O objetivo deste estudo foi avaliar a influência do uso do solo na diversidade morfológica de colêmbolos e verificar a relação destes organismos com os atributos físicos, químicos e microbiológicos do solo. Foram coletadas amostras na região Sul de Santa Catarina, envolvendo três municípios: Orleans, Lauro Müller e Siderópolis, nos sistemas de uso do solo (SUS) de floresta nativa (FN), reflorestamento de eucalipto (RE), pastagem perene (PA), integração lavoura-pecuária (ILP) e plantio direto (PD). As coletas de solo para determinação dos atributos edáficos e a instalação de armadilhas de queda, foram realizadas no inverno e verão, nos mesmos pontos. Os colêmbolos coletados foram contados e morfotipados e os dados foram analisados por meio da abundância, diversidade de Shannon-Wiener (H') e Margalef, índice de dominância de Simpson (D), uniformidade de Pielou (J), riqueza de morfotipos e Análise de Componentes Principais (ACP). Os morfotipos de Collembola foram influenciados pelas condições de manejo de cada sistema, sobretudo o impacto dos SUS nesses organismos depende da intensidade das práticas florestais/agrícolas utilizadas, incluindo rotações culturais e preparo do solo.

Abstract: The aim of this study was to evaluate the influence of soil use on the morphological diversity of springtails and to verify the relationship of these organisms with soil physical, chemical, and microbiological properties. Samples were collected in the Southern region of Santa Catarina, involving three municipalities: Orleans, Lauro Müller, and Siderópolis, in the land use systems (LUS) of native forest (NF), Eucalyptus plantation (EP), pasture (PA), integrated crop-livestock (ICL), and no-tillage (NT). Soil samples to determine edaphic properties and pitfall traps were collected in winter and summer, in the same areas. The collected springtails were counted and morphotyped and the data were analyzed through abundance, Shannon-Wiener diversity (H') and Margalef index, Simpson dominance index (D), Pielou evenness index (J), morphotype richness, and Principal Components Analysis (PCA). Springtails morphotypes were influenced by the management conditions of each system, especially the impact of LUS on these organisms depends on the intensity of the forest/agricultural practices used, including crop rotation and soil preparation.

ABSTRACT: Springtails (Collembola) are soil organisms with wide morphological diversity and are sensitive to alterations in the soil, regardless of whether they are human-caused or not. The aim of this study was to evaluate the influence of land use on the morphological diversity of springtails and verify their relationships with soil physical, chemical, and microbiological properties. Samples were collected in the eastern region of Santa Catarina, in three municipalities: Joinville, Blumenau, and Timbó. They included the following land use systems (LUSs): native forest (NF), Eucalyptus plantation (EP), pasture (PA), integrated crop-livestock (ICL), and no tillage (NT). Samples were collected to determine soil properties, and pitfall traps were set in the winter and summer at the same points. The captured springtails were counted and morphotyped, observing features such as presence or absence of ocelli and setae, pigmentation, antenna length, and furcula length. The data were analyzed based on abundance, the Shannon-Wiener (H') and Margalef diversity indices, Pielou's evenness index (J), morphotype richness, modified Soil Biological Quality index (QBS), and Principal Component Analysis (PCA). Springtails abundance was higher in ICL and PA, whereas morphotype richness was higher in NF and ICL in the winter. The Shannon-Wiener and Margalef indices were higher in the winter in NF. In the summer, only H' differed significantly among the LUSs and was higher in NF. The QBS values did not precisely follow the human intervention gradient in either of the two periods. The PCA showed difference among the periods and LUSs. In the winter, the occurrence of morphotypes was related to soil microbiological and chemical properties, whereas in the summer, the distribution of morphotypes was explained by soil physical and chemical properties. Morphological diversity analysis is a good alternative to study springtail distribution and soil biological quality, especially when associated with multivariate techniques.

Este trabalho se propôs a analisar as contribuições do grupo como um espaço de estudo, pesquisa e desenvolvimento de competências em/sobre a Educação Interprofissional. Apresenta nuanças do estudo de caso e ancorou-se na abordagem qualitativa. As 14 narrativas conduziram ao campo das experiências e representações, objeto de compreensão, análise e interpretação da pesquisa. Da análise temática emergiram três eixos de categoria: motivações, expressando os movimentos de busca, ingresso e permanência; grupo como espaço de aprendizagem compartilhada e prática colaborativa, com dimensões intersubjetiva, pessoal, institucional; e grupo como processo de consolidação e reconstrução permanentes, com desafios na construção das aprendizagens, no processo grupal e na publicização. O grupo caracteriza-se como locus privilegiado para o compartilhamento de saberes, produção de conhecimentos e construção de aprendizagens.

This study aimed to analyse the contribution of groups as a space of study, research and development of competencies in/on Interprofessional Education. It has nuances of the case study and was based on the qualitative approach. Fourteen narratives led to the field of experiences and representations, which is the object of understanding, analysis and interpretation of this research. Three categories emerged from the thematic analysis: motivations, which express search, admission, and permanence movements; the group as a shared learning and collaborative practice space, with intersubjective, personal, and institutional dimensions; and the group as a process of permanent consolidation and reconstruction, with challenges in building knowledge, forming groups, and publicizing. The group is characterized as a privileged locus for knowledge sharing and production, as well as for the construction of learning.

La investigación tuvo el objetivo de analizar las contribuciones del grupo como un espacio de estudio, investigación y desarrollo de competencias en/sobre la Educación Interprofesional. Presenta aspectos del estudio de caso y se basó en el abordaje cualitativo. Las 14 narraciones llevaron al campo de las experiencias y representaciones, objeto de comprensión, análisis e interpretación de la investigación. Del análisis temático surgieron tres ejes de categoría: motivaciones, expresando los movimientos de búsqueda, ingreso y permanencia; grupo como espacio de aprendizaje compartido y práctica colaborativa con dimensiones intersubjetiva, personal e institucional; y grupo como proceso de consolidación y de reconstrucción permanentes, con desafíos en la construcción de los aprendizajes, en el proceso grupal y en la difusión al público. El grupo se caracteriza como locus privilegiado para la compartición de saberes, producción de conocimientos y construcción de aprendizajes.

Este trabalho se propôs a analisar as contribuições do grupo como um espaço de estudo, pesquisa e desenvolvimento de competências em/sobre a Educação Interprofissional. Apresenta nuanças do estudo de caso e ancorou-se na abordagem qualitativa. As 14 narrativas conduziram ao campo das experiências e representações, objeto de compreensão, análise e interpretação da pesquisa. Da análise temática emergiram três eixos de categoria: motivações, expressando os movimentos de busca, ingresso e permanência; grupo como espaço de aprendizagem compartilhada e prática colaborativa, com dimensões intersubjetiva, pessoal, institucional; e grupo como processo de consolidação e reconstrução permanentes, com desafios na construção das aprendizagens, no processo grupal e na publicização. O grupo caracteriza-se como locus privilegiado para o compartilhamento de saberes, produção de conhecimentos e construção de aprendizagens.

This study aimed to analyse the contribution of groups as a space of study, research and development of competencies in/on Interprofessional Education. It has nuances of the case study and was based on the qualitative approach. Fourteen narratives led to the field of experiences and representations, which is the object of understanding, analysis and interpretation of this research. Three categories emerged from the thematic analysis: motivations, which express search, admission, and permanence movements; the group as a shared learning and collaborative practice space, with intersubjective, personal, and institutional dimensions; and the group as a process of permanent consolidation and reconstruction, with challenges in building knowledge, forming groups, and publicizing. The group is characterized as a privileged locus for knowledge sharing and production, as well as for the construction of learning.

La investigación tuvo el objetivo de analizar las contribuciones del grupo como un espacio de estudio, investigación y desarrollo de competencias en/sobre la Educación Interprofesional. Presenta aspectos del estudio de caso y se basó en el abordaje cualitativo. Las 14 narraciones llevaron al campo de las experiencias y representaciones, objeto de comprensión, análisis e interpretación de la investigación. Del análisis temático surgieron tres ejes de categoría: motivaciones, expresando los movimientos de búsqueda, ingreso y permanencia; grupo como espacio de aprendizaje compartido y práctica colaborativa con dimensiones intersubjetiva, personal e institucional; y grupo como proceso de consolidación y de reconstrucción permanentes, con desafíos en la construcción de los aprendizajes, en el proceso grupal y en la difusión al público. El grupo se caracteriza como locus privilegiado para la compartición de saberes, producción de conocimientos y construcción de aprendizajes.

ABSTRACT INTRODUCTION: Schistosomiasis, a parasitic disease caused by trematode flatworms of the genus Schistosoma, affects more than 200 million people worldwide, and its control is dependent on a single drug, praziquantel. Here, we report the in vitro effect of rotundifolone, a monoterpene isolated from Mentha x villosa (Lamiaceae), on Schistosoma mansoni adult worms. METHODS: The in vitro effect of rotundifolone on adult Schistosoma mansoni was evaluated by analysis of behavior and mortality and through a scanning electron microscopic analysis of ultrastructural changes in the tegument of the worms. RESULTS: At concentrations of 3.54 and 7.09μg/mL-1 rotundifolone, no worm mortality was observed at any of the sampling intervals. A minor reduction in movement of the tail, suckers, and gynecophoral canal membrane was observed after 96 h of exposure to 7.09μg/mL-1 rotundifolone. At 70.96μg/mL-1, a lack of movement was observed from 72h onwards and all worms were deemed dead; similar effects were observed at 48h with 177.4μg/mL-1, and at 24h with 354.8μg/mL-1 and 700.96μg/mL-1. Rotundifolone also caused death of all parasites and separation of coupled pairs into individual males and females after 24h at 354.8μg/mL-1. CONCLUSIONS: The main changes in the tegument induced by the different ROT treatments were: after 24h incubation, bubble lesions spread over the entire body and loss of tubercles occurred in some regions of the ventral region.

ABSTRACT Against a backdrop of global equity in cancer prevention and control, the National Institute of Neoplastic Diseases (INEN), a national reference center, has designed and developed innovative strategies and programs with the intent to meet institutional goals through health promotion interventions and cancer prevention, diagnosis, and treatments that benefit the national population. The INEN Schools and Centers of Excellence have played an important role in the process of determining the results of these actions. The Center of Excellence in Cervical Cancer Training is an interventional pioneer that has applied a methodological design intended to improve health professional skills and has disseminated this model to other Schools of Excellence. Through this intervention, the skills of 12,194 health professionals trained by the INEN have been strengthened with respect to nationwide promotion and primary and secondary prevention during the period of 2012-2015.

RESUMEN En el marco de las acciones globales en la prevención y control del cáncer, el Instituto Nacional de Enfermedades Neoplásicas (INEN), centro de referencia nacional, ha diseñado y desarrollado estrategias y programas innovadores que están orientados al cumplimiento de los objetivos institucionales a través de las intervenciones de promoción de la salud, prevención, diagnóstico y tratamiento del cáncer, que benefician a la población a nivel nacional. En el proceso de obtener resultados de estas acciones, las escuelas y centros de excelencia del INEN, han desarrollado un papel muy importante. El Centro de Excelencia en la Capacitación en Cáncer de Cuello Uterino es el pionero en estas intervenciones con diseño metodológico aplicado a la mejora de las competencias de los profesionales de la salud, siendo este modelo diseminado a las otras escuelas de excelencias. Como resultado de su intervención, se han logrado fortalecer las competencias de 12 194 profesionales de la salud, capacitados por el INEN en promoción y prevención primaria y secundaria, a nivel nacional, durante el periodo del 2012-2015.

Against a backdrop of global equity in cancer prevention and control, the National Institute of Neoplastic Diseases (INEN), a national reference center, has designed and developed innovative strategies and programs with the intent to meet institutional goals through health promotion interventions and cancer prevention, diagnosis, and treatments that benefit the national population. The INEN Schools and Centers of Excellence have played an important role in the process of determining the results of these actions. The Center of Excellence in Cervical Cancer Training is an interventional pioneer that has applied a methodological design intended to improve health professional skills and has disseminated this model to other Schools of Excellence. Through this intervention, the skills of 12,194 health professionals trained by the INEN have been strengthened with respect to nationwide promotion and primary and secondary prevention during the period of 2012-2015.

En el marco de las acciones globales en la prevención y control del cáncer, el Instituto Nacional de Enfermedades Neoplásicas (INEN), centro de referencia nacional, ha diseñado y desarrollado estrategias y programas innovadores que están orientados al cumplimiento de los objetivos institucionales a través de las intervenciones de promoción de la salud, prevención, diagnóstico y tratamiento del cáncer, que benefician a la población a nivel nacional. En el proceso de obtener resultados de estas acciones, las escuelas y centros de excelencia del INEN, han desarrollado un papel muy importante. El Centro de Excelencia en la Capacitación en Cáncer de Cuello Uterino es el pionero en estas intervenciones con diseño metodológico aplicado a la mejora de las competencias de los profesionales de la salud, siendo este modelo diseminado a las otras escuelas de excelencias. Como resultado de su intervención, se han logrado fortalecer las competencias de 12 194 profesionales de la salud, capacitados por el INEN en promoción y prevención primaria y secundaria, a nivel nacional, durante el periodo del 2012-2015.