The in silico study aimed to suggest phytochemicals from Commiphora leptophloeos leaves essential oil as therapies against coronavirus disease (COVID-19) (or severe acute respiratory syndrome coronavirus 2, SARS-CoV-2). For that, we used molecular docking (MD), absorption, distribution, metabolism, excretion, and toxicity (ADMET) parameters, and pharmacokinetic analysis. MD showed the presence of hydrophobic and hydrogen bonds for nine compounds. β-Selinene and bicyclogermacrene showed the best interaction values with the protein Mpro (ID: 6Y2F) (-5.9) and chimeric receptor complexed with its receptor human ACE2 (ID: 6VW1) (-6.1 and -5.5) proteins, as well as low gastrointestinal and high epithelial absorptions, medium permeability for Caco-2 cells and high epithelial permeability, low oral excretion, and were inhibitors of CYP2C19 and CYP2C9 enzymes. On the other hand, both were not permeable to the blood-brain barrier and inhibitors or substrates for glycoprotein-D, and showed carcinogenic potential, but only β-selinene was considered mutagenic. Although little bioavailable, both presented aspects structurally adequate, being compounds with moderate synthesis difficulty. Therefore, more analyses are necessary to evaluate the mechanism of action and unsatisfactory parameters foreseen in bioinformatic assays. COVID19 COVID 19 (COVID-19 2 SARSCoV2. SARSCoV2 SARSCoV SARS CoV . SARS-CoV-2) that MD, , (MD) absorption distribution metabolism excretion ADMET (ADMET analysis βSelinene β Selinene ID (ID 6Y2F YF Y F 5.9 59 5 9 (-5.9 ACE 6VW1 VW 6.1 61 6 1 (-6. 5.5 55 -5.5 proteins absorptions Caco2 Caco Caco- CYPC CYP C CYP2C1 CYP2C enzymes hand bloodbrain blood brain glycoproteinD, glycoproteinD glycoprotein D, D glycoprotein-D potential βselinene selinene mutagenic bioavailable adequate difficulty Therefore assays COVID1 (COVID-1 SARS-CoV-2 (MD 5. (-5. 6VW 6. (-6 -5. (COVID- SARS-CoV- (-5 (- -5 (COVID SARS-CoV ( -

ABSTRACT BACKGROUND: The identification and understanding of dietary factors and other characteristics that influence gestational weight gain can contribute to the formulation of strategies to promote healthy eating habits before and during pregnancy. OBJECTIVE: To investigate the association between dietary patterns, sociodemographic and obstetric characteristics, and health-related behaviors in pregnant women. DESIGN AND SETTING: A cross-sectional study was conducted on women undergoing prenatal care in the Unified Health System of Colombo, Paraná, Brazil, from February 2018 to September 2019. METHOD: A weekly food frequency questionnaire was administered, and dietary patterns were identified through factor analysis. Median regression models were constructed to identify the associations between dietary pattern scores and variables. RESULTS: Complete data were obtained from 495 pregnant women. Three dietary patterns were identified: 1) “healthy,” with higher factor loadings for the weekly consumption of raw vegetables, cooked vegetables, and fresh fruits; 2) “Western,” including soft drinks or artificial juice, candies, milk, and dairy products, and processed cold meat; and 3) “traditional,” beans and meat. Pregnant women aged 30 years or older (coefficient [Coef.] 0.86, 95% confidence interval [CI] 0.38–1.33) with moderate/intense physical activity (Coef. 0.32, 95% CI 0.02–0.62) had higher adherence to the “healthy” pattern. Adolescents and smokers adhered more to the “traditional” pattern (Coef. 0.17, 95% CI 0.01–0.33). CONCLUSION: Age, smoking status, and physical activity were associated with dietary patterns in pregnant women. BACKGROUND pregnancy OBJECTIVE healthrelated health related SETTING crosssectional cross sectional Colombo Paraná Brazil 201 2019 METHOD administered analysis variables RESULTS 49 1 healthy, “healthy, vegetables fruits 2 Western, Western “Western, juice candies milk products meat 3 traditional, traditional “traditional, coefficient Coef. Coef [Coef. 086 0 86 0.86 95 [CI 0.38–1.33 038133 38 33 moderateintense moderate intense (Coef 032 32 0.32 0.02–0.62 002062 02 62 “healthy “traditional 017 17 0.17 0.01–0.33. 001033 0.01–0.33 . 01 0.01–0.33) CONCLUSION Age status 20 4 “Western [Coef 08 8 0.8 9 0.38–1.3 03813 03 0.3 0.02–0.6 00206 6 0.1 00103 0.01–0.3 0. 0.38–1. 0381 0.02–0. 0020 0010 0.01–0. 0.38–1 038 0.02–0 002 001 0.01–0 0.38– 0.02– 00 0.01– 0.38 0.02 0.01 0.0

Abstract Plant species in the white-sandy forests are subject to unstable soils, high salinity, luminosity, extreme temperatures, and flooding caused by tidal cycles. Protium heptaphyllum, a tree species in the Burseraceae family known for its resin production, occurs in both floodable and non-floodable areas. We investigated differences in the accumulated herbivory indexes in leaves during the leaflet lifespan and correlated these data with leaf morphoanatomical traits in plants from floodable and non-floodable areas. Samples of young and mature leaves were processed using standard plant anatomy techniques. The percentage of leaf area consumed by herbivores and quantitative morphoanatomical data were subjected to MANOVA and ANOVA. Herbivory indexes of young and mature leaves were similar between plants from floodable and non-floodable areas. The morphoanatomical features of young leaves were also similar in plants from both areas. However, mature leaves from individuals in the floodable area exhibited longer leaflets and a higher abundance of wider secretory canals compared to plants from the non-floodable area. We suggest that most leaf consumption by herbivores occurs during the early stages of leaf development when there are fewer chemical defenses, and the leaflets are more tender. whitesandy white sandy soils salinity luminosity temperatures cycles heptaphyllum production nonfloodable non areas techniques ANOVA However defenses tender

Resumo As espécies vegetais das restingas estão sujeitas a solos instáveis, alta salinidade e luminosidade, temperaturas extremas e inundações causadas pelos ciclos das marés. Protium heptaphyllum, uma espécie arbórea de Burseraceae conhecida pela produção de resina, ocorre em áreas inundáveis e não inundáveis. Nós investigamos a ocorrência de diferenças nos índices de herbivoria acumulada durante o desenvolvimento dos folíolos e correlacionamos esses dados com as características morfoanatômicas das folhas em plantas de áreas inundáveis e não inundáveis. Amostras de folhas jovens e maduras foram processadas conforme técnicas usuais em anatomia vegetal. A porcentagem de área foliar consumida pelos herbívoros e os dados morfoanatômicos quantitativos foram submetidos à MANOVA e à ANOVA. Os índices de herbivoria de folhas jovens e maduras foram semelhantes entre plantas de áreas inundáveis e não inundáveis. As características morfoanatômicas das folhas jovens também foram semelhantes nas plantas de ambas as áreas. Entretanto, folhas maduras de indivíduos da área inundável exibiram folíolos mais longos e canais secretores mais abundantes e amplos em comparação às plantas da área não inundável. Sugerimos que a maior parte do consumo de folhas pelos herbívoros ocorre durante os estágios iniciais de desenvolvimento das folhas, quando há menor defesa química e os folíolos são mais tenros. instáveis luminosidade marés heptaphyllum resina vegetal ANOVA Entretanto tenros

Abstract This research assessed the efficiency of chemically modified tannins as coagulants for water treatment. Tannins from Anacardium occidentale (cashew tree) and Mimosa caesalpiniifolia (‘sabiá’) barks and seedless fruits of Anadenanthera colubrina (‘angico’) and Pityrocarpa moniliformis (‘angico de bezerro’) were evaluated after cationization to remove turbidity from water. After extraction, the total solids content (TSC), Stiasny index (SI), and total condensed tannins content (TCC) of the tannins extracts were determined. Extracted tannins were converted into powders and cationized. Then, the cationized tannins' effectiveness on water turbidity removal, sedimentation time, and effect on pH were assessed. Three concentrations of each type of tannin were used to evaluate flocculant efficiency: 50, 100, and 150 mg L-1. Although the P. moniliformis extract had a higher TSC value (56.06%), it presented the lowest SI (0.42%) and TTC (0.23%) values. M. caesalpiniifolia had the lowest TSC (9.18%) and the highest SI (91.27%), while Ac occidentale stood out with the highest TCC (19.83%). All species have shown potential for tannin production and efficiently removed turbidity at all concentrations. However, only A. occidentale, at a concentration of 100 mg L-1, presented a nephelometric turbidity unit of 2.4, reaching the potability standards required by international specifications and, therefore, being indicated for water treatment. treatment cashew tree ‘sabiá sabiá (‘sabiá’ ‘angico angico (‘angico’ bezerro bezerro’ extraction TSC, , (TSC) SI, (SI) (TCC determined Then removal time 50 15 L1. L1 L 1. 1 L-1 P 56.06%, 5606 56.06% 56 06 (56.06%) 0.42% 042 0 42 (0.42% 0.23% 023 23 (0.23% values M 9.18% 918 9 18 (9.18% 91.27%, 9127 91.27% 91 27 (91.27%) 19.83%. 1983 19.83% . 19 83 (19.83%) However A 10 L1, 1, 24 2 4 2.4 therefore (‘sabiá (TSC (SI 5 L- 560 56.06 (56.06% 0.42 04 (0.42 0.23 02 (0.23 9.18 (9.18 912 91.27 (91.27% 198 19.83 8 (19.83% 2. 56.0 (56.06 0.4 (0.4 0.2 (0.2 9.1 (9.1 91.2 (91.27 19.8 (19.83 56. (56.0 0. (0. 9. (9. 91. (91.2 19. (19.8 (56. (0 (9 (91. (19. (56 ( (91 (19 (5 (1

Resumo O presente trabalho teve como objetivo avaliar a eficiência de taninos quimicamente modificados como coagulantes para tratamento de água. Os taninos das cascas de Anacardium occidentale (cajueiro) e Mimosa caesalpiniifolia (sabiá) e dos frutos sem sementes de Anadenanthera colubrina (angico) e Pityrocarpa moniliformis (angico de bezerro) foram avaliados após cationização para remover a turbidez da água. Após a extração, os extratos de taninos tiveram o teor de sólidos totais (TST), o índice de Stiasny (IS) e o teor de taninos totais condensados (TCT). Os taninos extraídos foram convertidos em pó e cationizados. Em seguida, avaliou-se a eficácia dos taninos cationizados na remoção da turbidez e o tempo de sedimentação além do efeito no pH da água. Para avaliar a eficiência dos taninos cationizados como floculantes foram utilizadas três concentrações de cada tipo de material: 50, 100 e 150 mg L-1. Embora o extrato de P. moniliformis tenha apresentado maior valor de TST (56,06%), apresentou os menores valores de IS (0,42%) e TCT (0,23%). Os taninos da casca de M. caesalpiniifolia apresentou o menor TST (9,18%) e o maior IS (91,27%), enquanto os derivados de A. occidentale se destacaram pelo maior TCT (19,83%). Todas as espécies demonstraram potencial para produção de taninos e foram eficientes em remover a turbidez da água em todas as concentrações. Porém, apenas o A. occidentale, na concentração de 100 mg L-1, apresentou unidade de turbidez nefelométrica de 2,4, atingindo os padrões de potabilidade exigidos pelas especificações internacionais e, portanto, sendo indicado para tratamento de água. cajueiro (cajueiro sabiá (sabiá angico bezerro extração TST, , (TST) (IS TCT. . (TCT) seguida avaliouse avaliou material 50 10 15 L1. L1 L 1. 1 L-1 P 56,06%, 5606 56,06% 56 06 (56,06%) 0,42% 042 0 42 (0,42% 0,23%. 023 0,23% 23 (0,23%) M 9,18% 918 9 18 (9,18% 91,27%, 9127 91,27% 91 27 (91,27%) A 19,83%. 1983 19,83% 19 83 (19,83%) Porém L1, 1, 24 2 4 2,4 portanto (TST (TCT 5 L- 560 56,06 (56,06% 0,42 04 (0,42 02 0,23 (0,23% 9,18 (9,18 912 91,27 (91,27% 198 19,83 8 (19,83% 2, 56,0 (56,06 0,4 (0,4 0,2 (0,23 9,1 (9,1 91,2 (91,27 19,8 (19,83 56, (56,0 0, (0, (0,2 9, (9, 91, (91,2 19, (19,8 (56, (0 (9 (91, (19, (56 ( (91 (19 (5 (1

Abstract Tea is identified as the second most consumed drink in the world, and its frequent intake is related to several benefits to human health, considering its antimutagenic, anticarcinogenic, antimicrobial, anti-inflammatory, antihistamine, diuretic, calming, and above all, antioxidant effects. These effects are often associated with the action of the phenolic compounds contained in these infusions. In Brazil, among the most consumed infusions are the teas of chamomile (Matricaria chamomilla L.), lemongrass (Cymbopogon citratus (D.C.) Stapf), lemon balm (Melissa officinalis L.), anise (Pimpinella anisum L.), yerba mate (Ilex paraguariensis A. St.-Hil), peppermint (Mentha piperita L.), and green/black tea (Camellia sinensis L.). Therefore, said popularity is the reason why the mentioned species were chosen to be evaluated on inflammatory enzymes. The activity of phospholipases A2 was reduced by more than 25% after treatment with black tea and yerba mate. The most significant inhibition of protease activity was observed after incubation with black tea (40.74%), green tea (31.48%) and yerba mate (25.93%). Infusions of black and green tea reduced hemolysis in semisolid and liquid media, and for the latter, reductions of up to 50% of hemolytic activity were observed, indicating an anti-inflammatory potential of the samples. Plasma incubations with green tea, black tea and lemon balm and subsequent addition of venom (1:10 ratio; tea:PBS, v:v) prolonged the coagulation time of citrated plasma by approximately twice compared to the positive control. All controls with pure tea had a thrombolytic character, in higher proportions than the venom control, especially chamomile (273.55% dissolution). Phenolic compounds derived from phenolic acids, flavonoids, and tannins are identified as the main agents that promote the biological effects observed in this study. This is mainly due to their anti-catalytic properties exerted on inflammatory enzymes and as chelating agents of enzymatic co-factors. The evaluated teas showed potential for nutraceutical use, thus pointing to the possibility of use as an adjuvant in the treatment of diseases linked to hemostasis. world health antimutagenic anticarcinogenic antimicrobial antiinflammatory, antiinflammatory anti inflammatory, antihistamine diuretic calming all Brazil Matricaria L., L L. , L.) Cymbopogon D.C. DC D C (D.C. Stapf, Stapf Stapf) Melissa Pimpinella Ilex A St.Hil, StHil St. Hil St St.-Hil) Mentha greenblack Camellia L.. . Therefore 25 40.74%, 4074 40.74% 40 74 (40.74%) 31.48% 3148 31 48 (31.48% 25.93%. 2593 25.93% 93 (25.93%) media latter 50 samples 110 1 10 (1:1 ratio teaPBS, teaPBS PBS, PBS tea:PBS vv v v:v control character 273.55% 27355 273 55 (273.55 dissolution. dissolution dissolution) acids flavonoids study anticatalytic catalytic cofactors. cofactors co factors. factors co-factors hemostasis D.C (D.C St.Hil St.-Hil 2 407 40.74 4 7 (40.74% 31.48 314 3 (31.48 259 25.93 9 (25.93% 5 11 (1: 273.55 2735 27 (273.5 40.7 (40.74 31.4 (31.4 25.9 (25.93 (1 273.5 (273. 40. (40.7 31. (31. 25. (25.9 ( 273. (273 (40. (31 (25. (27 (40 (3 (25 (2 (4

Abstract The chemical and nutritional characteristics of the four distillers dried grains with solubles (DDGS) were determined for dry matter (DM), mineral matter (MM), crude protein (CP), ether extract (EE), neutral detergent fiber (NDF) and gross energy analyzed (GEa), from which the values of gross energy (GE), digestible energy (DE), metabolizable energy (ME) and net energy (NE) were estimated. There were differences in the contents of EE, NDF, GEa, GE, DE, ME and NE between the lots. A total of 40 barrows with an initial weight of 72.69 ± 5.66 kg were assigned to a randomized block design, fed diets containing 0, 100, 200 and 300 g kg−1 DDGS for 28 days and were subjected to performance assessment. The inclusion of DDGS in the diets did not affect daily feed intake (DFI), daily weight gain (DWG) or feed conversion (FC) but linearly reduced the final weight. Based on the results of the performance and prices of ingredients in the local market, we calculated the costs of feed, revenue and gross operating profit (GOP). Inclusions of DDGS in pig diets reduced costs and revenues but did not affect GOP. DDGS presented chemical and nutritional variation between the lots. Levels of inclusion up to 300 g kg−1 DDGS do not affect finishing pig performance and profitability. (DDGS DM, DM , (DM) MM, MM (MM) CP, CP (CP) EE (EE) NDF (NDF GEa (GEa) GE (GE) DE (DE) (ME (NE estimated lots 4 7269 72 69 72.6 566 5 66 5.6 design 0 100 20 30 kg1 1 kg− 2 assessment DFI, DFI (DFI) DWG (DWG FC (FC market GOP . (GOP) profitability (DM (MM (CP (EE (GEa (GE (DE 726 7 6 72. 56 5. 10 3 (DFI (GOP

Resumo As características químicas e nutricionais de quatro grãos secos destilados com solúveis (DDGS) foram determinados quanto a matéria seca (MS), matéria mineral (MM), proteína bruta (PB), extrato etéreo (EE), fibra em detergente neutro (FDN) e energia bruta analisada (EBa) dos quais os valores de energia bruta (EB), digestível (ED), metabolizável (EM) e liquida (EL) foram estimados. Houve diferenças no conteúdo de EE, FDN, EBa, EB, ED, EM e EL entre lotes. Um total de 40 machos castrados 72.69 ± 5.66 kg foram distribuídos em blocos ao caso, alimentados com dietas com 0, 100, 200 e 300 g kg−1 DDGS por 28 dias. A inclusão de DDGS não afetou consumo de ração diário, ganho de peso diário e conversão alimentar mas reduziu de forma linear o peso final. Baseados nos resultados de desempenho, preços de ingredientes e mercado local foram calculados os custos de ração, receita e lucro operacional bruto (LOB). Inclusões de DDGS em dietas para suínos reduziu custos e receitas mas não afetou LOB. DDGS apresentam variação química e nutricional entre lotes. Níveis de até 300 g kg−1 de DDGS não afetam desempenho e lucratividade com suínos em terminação. (DDGS MS, MS , (MS) MM, MM (MM) PB, PB (PB) EE (EE) FDN (FDN EBa (EBa EB (EB) ED (ED) (EM (EL estimados lotes 4 7269 72 69 72.6 566 5 66 5.6 caso 0 100 20 30 kg1 1 kg− 2 dias final LOB . (LOB) terminação (MS (MM (PB (EE (EB (ED 726 7 6 72. 56 5. 10 3 (LOB

Resumo Este artigo tem como objeto a avaliação de desempenho docente na Educação Superior. Diante da obrigatoriedade legal de avaliar o desempenho do professor para fins de concessão de progressão e/ou promoção na carreira e da resistência de sindicatos e associações docentes a essa avaliação, pergunta-se: é possível avaliar o desempenho para além dos aspectos regulatórios da carreira, de tal forma que se possa resistir à implantação da cultura da performatividade em Instituições de Educação Superior? As análises foram feitas a partir: da inclusão daquela avaliação na carreira do magistério sob influência de organismos internacionais; da incorporação de elementos próprios da cultura performativa; da resistência, por meio do uso formativo dos resultados da avaliação de desempenho docente; e dos relatos de professores que atuam em cursos de graduação. As considerações finais indicam que a resistência à cultura performativa deve ser um compromisso assumido tanto individual quanto institucionalmente. Superior eou ou perguntase pergunta pergunta-se partir internacionais graduação institucionalmente

Resumen Este artículo tiene como objetivo evaluar el desempeño docente en la Educación Superior. Dada la obligación legal de evaluar el desempeño docente con el fin de otorgar progresión y/o promoción profesional y la resistencia de sindicatos y asociaciones docentes a esta evaluación, surge la siguiente pregunta: ¿es posible evaluar el desempeño más allá de los aspectos normativos de la carrera, de tal manera que se pueda resistir la implementación de la cultura de la performatividad en las Instituciones de Educación Superior? Los análisis se realizaron con base en: la inclusión de esa evaluación en la carrera docente bajo la influencia de organismos internacionales; la incorporación de elementos propios de la cultura performativa; resistencia, a través del uso formativo de los resultados de la evaluación del desempeño docente; e informes de profesores que trabajan en cursos de pregrado. Las consideraciones finales indican que la resistencia a la cultura performativa debe ser un compromiso asumido tanto individual como institucionalmente. Superior yo o pregunta es internacionales pregrado institucionalmente

Abstract This article aims to evaluate teaching performance in Higher Education. Given the legal obligation to evaluate teacher performance for granting career progression and/or promotion and the resistance of unions and teaching associations to this evaluation, the following question arises: is it possible to evaluate performance beyond the regulatory aspects of the career, in such a way that the implementation of the culture of performativity in Higher Education Institutions can be resisted? The analyses were carried out based on the inclusion of that assessment in the teaching career under the influence of international organizations; the incorporation of elements specific to performative culture; resistance, through the formative use of the results of the teaching performance assessment; and reports from professors who work in undergraduate courses. The final considerations indicate that resistance to performative culture must be a commitment assumed both individually and institutionally. andor or evaluation arises resisted organizations courses institutionally

ABSTRACT Objectives: To analyze the impact of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic on ocular tissue donations, assessing lost opportunities for potential donors due to the suspension of collections and changes in eligibility criteria, as well as hospital eligibility rates of donors and causes of non-donation. Methods: Data from patients who died in cardiopulmonary arrest in a Brazilian university hospital in 2020 were analyzed. The number of donations made, the number of deaths potentially eligible for donation, and the causes of non-donation were compared during the three periods of 2020: period 1, pre-pandemic (January 1 to March 18, 2020), period 2, with suspension of donations in cardiorespiratory arrest (March 19 to September 19, 2020), and period 3, of collections with epidemiological screening for SARS-CoV-2 and reduction of the age range of donors less than 65 years old (September 20 to December 31 2020). Results: There were 710 circulatory deaths in 2020. The hospital eligibility rate was 5.7% among 140 deaths in the pre-pandemic period 1, 11.9% among 395 patients during the suspension of uptake in pandemic period 2, and 3.4% among 175 patients during age group restrictions and coronavirus disease 2019 (COVID-19) screening (p:0.004). Forty-seven patients who died in period 2 represented a loss of donation opportunities due to the suspension of collections, and 13 (7.6%) of the 175 patients in period 3 were ineligible due to the reduction in age group. Due to pandemic restrictions, eighty-one percent of the 75 eligible patients without clinical contraindications had limited tissue donation offers. Only one patient was considered ineligible for donation due to clinical-epidemiological screening for SARS-CoV-2. Serious infections were the leading cause of non-donation in 50.7, 48.1, and 47.4% of deaths in the three periods (p:0.615). Conclusion: The SARS-CoV-2 pandemic significantly affected the procurement of ocular tissues for transplants due to the restrictive measures implemented for safety reasons, leading to the loss of donation opportunities for 81% of families. Age restrictions significantly reduced potential donor eligibility rates. Serious infections were the leading cause of non-donation of ocular tissue, but it did not increase significantly in this study during the pandemic, in the period studied. Objectives SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 criteria nondonation. nondonation non donation. Methods 202 analyzed made prepandemic pre January 18 2020, , 2020) SARS-CoV- 6 . Results 71 57 5 7 5.7 14 119 11 9 11.9 39 34 4 3.4 17 201 COVID19 COVID (COVID-19 p0.004. p0004 p 0.004 0 004 (p:0.004) Fortyseven Forty seven 7.6% 76 (7.6% eightyone eighty offers clinicalepidemiological SARSCoV2. 2. 507 50 50.7 481 48 48.1 474 47 47.4 p0.615. p0615 0.615 615 (p:0.615) Conclusion reasons 81 families studied (SARS-CoV- SARS-CoV 5. 11. 3. COVID1 (COVID-1 p0 p0.004 p000 0004 0.00 00 (p:0.004 7.6 (7.6 50. 48. 47. p0.615 p061 0615 0.61 61 (p:0.615 8 (SARS-CoV (COVID- p0.00 p00 000 0.0 (p:0.00 7. (7. p0.61 p06 061 0.6 (p:0.61 (COVID p0.0 0. (p:0.0 (7 p0.6 06 (p:0.6 p0. (p:0. ( (p:0 (p: (p

RESUMO Objetivos: Analisar o impacto da pandemia da síndrome respiratória aguda grave do coronavírus 2 (SARS-CoV-2) nas doações de tecidos oculares quanto às perdas de oportunidade de potenciais doadores devido à suspensão das captações e às mudanças nos critérios de elegibilidade, nas taxas de elegibilidade hospitalar de doadores e causas de não doação. Métodos: Foram analisados dados de pacientes falecidos em parada cardiorrespiratória (PCR) em um hospital universitário brasileiro em 2020. Compararam-se o número de doações efetivadas, o número de óbitos potencialmente elegíveis para doação e as causas de não doação nos três períodos de 2020: período 1, pré-pandemia (1 de janeiro a 18 de março de 2020), período 2, com suspensão de doações em PCR (19 de março a 19 de setembro de 2020), e período 3, de captações com triagem epidemiológica para SARS-CoV-2 e redução da faixa etária de doadores até 65 anos (20 de setembro a 31 de dezembro de 2020). Resultados: Houve 710 óbitos por morte circulatória em 2020. A taxa de elegibilidade hospitalar foi de 5,7% em 140 óbitos no período 1, 11,9% de 395 pacientes durante a suspensão da captação no período 2 e 3,4% de 175 pacientes durante as restrições da faixa etária e triagem para doença do coronavírus 2019 (COVID-19) (p = 0,004). Os 47 pacientes falecidos no período 2 representaram perda de oportunidade de doação devido à suspensão das captações e 13 (7,6%) dos 175 pacientes no período 3 não foram elegíveis devido à redução da faixa etária. Dentre os elegíveis sem contraindicação clínica, 81% dos 75 pacientes tiveram limitação na oferta de doação devido às restrições da pandemia. Apenas um paciente foi considerado inelegível para doação devido à triagem clínico-epidemiológica para SARS-CoV-2. As infecções graves foram a principal causa de não doação em 50,7, 48,1 e 47,4% dos óbitos nos três períodos (p = 0,615). Conclusão: A pandemia de SARS-CoV-2 afetou significativamente a captação de tecidos oculares para transplantes devido às medidas restritivas implementadas por motivos de segurança, resultando na perda de oportunidade de doação para 81% das famílias. As taxas de elegibilidade de potenciais doadores foram reduzidas significativamente pela restrição de faixa etária. As infecções graves foram a principal causa de não doação de tecidos oculares, porém, neste estudo, não houve aumento significativo durante o período pandêmico estudado. Objetivos SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 Métodos (PCR 2020 Compararamse Compararam se efetivadas 1 prépandemia pré ( 2020, , 2020) SARS-CoV- 6 20 (2 . Resultados 71 57 5 7 5,7 14 119 11 9 11,9 39 34 4 3,4 17 201 COVID19 COVID (COVID-19 p 0,004. 0004 0,004 0 004 0,004) 7,6% 76 (7,6% clínica 81 clínicoepidemiológica clínico SARSCoV2. 2. 507 50 50,7 481 48 48, 474 47,4 0,615. 0615 0,615 615 0,615) Conclusão segurança famílias porém estudo estudado (SARS-CoV- 202 SARS-CoV 5, 11, COVID1 (COVID-1 000 0,00 00 7,6 (7,6 8 50, 47, 061 0,61 61 (SARS-CoV (COVID- 0,0 7, (7, 06 0,6 (COVID 0, (7

Resumo Os sistemas costeiros abrangem uma variedade de ecótonos que são importantes para as espécies de peixes, fornecendo diversos micro-habitats e áreas para alimentação, proteção contra predação, reprodução e áreas para recrutamento. No entanto, a maioria desses sistemas enfrenta grandes ameaças de atividades humanas. Considerando os níveis crescentes de perturbação humana nos ecossistemas costeiros, a compreensão das associações peixe-habitat pode fornecer informações importantes sobre os padrões de ocorrência e distribuição de espécies em sistemas afetados pelo homem, que podem apoiar o desenvolvimento de medidas eficazes de conservação e gestão. Neste contexto, investigamos a relação entre os cavalos-marinhos (Hippocampus reidi) e a complexidade do habitat e diferentes espécies de fixação, para determinar a possível variação entre locais e entre estações do ano. Os dados foram obtidos nos recifes rochosos das baías de Guanabara (Praia da Urca) e Sepetiba (Ilha das Duas Irmãs), no sudeste do Brasil, por mergulho livre ao longo de transectos fixos. Os cavalos-marinhos foram contados, e o substrato usado por cada indivíduo foi registrado e identificado como espécie ou atribuído a um grupo morfofuncional. As praias diferiram quanto à composição e grupos morfofuncionais, embora compartilhando alguns grupos morfofuncionais. Os cavalos-marinhos foram mais frequentemente associados a substratos arborescentes/ramificados em ambos os locais, a foliáceos e maciços. A associação com algas foi particularmente encontrada na Urca, enquanto o coral Carijoa riisei na Ilha de Duas Irmãs. peixes microhabitats micro habitats alimentação predação recrutamento entanto humanas peixehabitat peixe homem gestão contexto cavalosmarinhos cavalos marinhos Hippocampus reidi fixação ano Praia Urca Irmãs, Irmãs , Irmãs) Brasil fixos contados morfofuncional morfofuncionais arborescentesramificados arborescentes ramificados maciços

Abstract Coastal systems encompass a range of ecotones that are important for fish species, providing diverse micro-habitats and grounds for foraging, protection from predation, reproduction and areas for recruitment. However, most of these systems face major threats from human activities. Considering the increasing levels of human disturbance in coastal ecosystems, understanding fish-habitat associations may provide important insights into patterns of species occurrence and distribution in human-impacted systems, which can support the development of effective conservation and management measures. In this context, we investigated the relationship between seahorses (Hippocampus reidi) and both habitat complexity and different holdfast species, to determine possible variation between locations and among seasons. Data were obtained from the rocky reefs of Guanabara (Urca Beach) and Sepetiba (Duas Irmãs Island) bays, in southeastern Brazil. Seahorses were counted, and the holdfast being used by each individual was recorded and identified to species or assigned to a morphofunctional group. The beaches differed in holdfast composition and morphofunctional groups, yet sharing some morphofunctional groups. Seahorses were more frequently associated with branching holdfasts at both sites, and also with foliaceous and massive. Association with algae were particularly found in Urca, while the coral Carijoa riisei in Duas Irmãs Island. microhabitats micro habitats foraging predation recruitment However activities ecosystems fishhabitat humanimpacted impacted measures context Hippocampus reidi seasons Urca Beach Island bays Brazil counted group groups sites massive

SUMMARY OBJECTIVE: The aim of this study was to understand the dynamics of families with children with myelomeningocele undergoing intrauterine fetal surgery. METHODS: A retrospective cohort pilot study was carried out with 11 mothers of children who had undergone intrauterine myelomeningocele repair. Participants in this study responded to an electronic questionnaire (via Google Forms), developed by the study authors, that consisted of 22 multiple-choice questions, of which 17 were closed-ended and 5 had a standardized format. RESULTS: The mean (± standard deviation) of the mothers’ age was 37.6 (± 3.5) years. The median of gestational age at delivery and birthweight were 34.9 (range, 33 to 36.1) weeks and 2,300 (range, 1,950 to 2,763) g, respectively. The majority of mothers were white (81.8%), had university degree (81.8%), were Catholic (63.6%), and were married (100%). The majority of mothers rated their relationship with their husband, family, and friends as excellent (54.5, 72.7, and 54.5%, respectively). All 11 mothers reported that the newborn with myelomeningocele was born <37 weeks gestation and the birthweight most often<2,500 g. Approximately 64% of the mothers reported that their child required adaptations or had special needs, of which walking aids (50%) and bladder control (50%) were the most common ones. CONCLUSION: Telemedicine proved to be a useful tool in the long-term follow-up of children who underwent intrauterine surgery to correct myelomeningocele. OBJECTIVE METHODS 1 repair via Forms, Forms , Forms) authors 2 multiplechoice multiple choice questions closedended closed ended format RESULTS ± ( deviation 376 37 6 37. 3.5 35 3 years 349 34 9 34. range, range (range 36.1 361 36 2300 300 2,30 1950 950 1,95 2,763 2763 763 g respectively 81.8%, 818 81.8% 81 8 (81.8%) 63.6%, 636 63.6% 63 (63.6%) 100%. 100 100% . (100%) husband family 54.5, 545 54 (54.5 727 72 7 72.7 54.5% respectively) <3 often2500 often 500 often<2,50 64 needs 50% 50 (50% ones CONCLUSION longterm long term followup follow up 3. 36. 230 30 2,3 195 95 1,9 2,76 276 76 81.8 (81.8% 63.6 (63.6% 10 (100% 54.5 (54. 72. < often250 often<2,5 (50 23 2, 19 1, 2,7 27 81. (81.8 63. (63.6 (100 54. (54 often25 often<2, (5 (81. (63. (10 often2 often<2 (81 (63 (1 often< (8 (6

Abstract Objective: To classifying the degree of swallowing impairment in the elderly, comparing clinical and instrumental assessment. Methods: This is a cross-sectional study with quantitative and qualitative analysis of clinical and instrumental assessment of 37 elderly, aged 60 -82 years, of both genders without neurological, oncological or systemic diseases, participated in this study. All participants were submitted to clinical evaluation and their results compared through fiberoptic endoscopic evaluation of swallowing considering liquid, pudding and solid food consistencies. Data were analyzed descriptively and statistically using the analysis of variance test (two-way ANOVA) and Tukey’s post hoc test (p< 0.05). Results: In the clinical evaluation there was a higher occurrence of moderate swallowing impairment, followed by functional swallowing, while in fiberoptic endoscopic evaluation of swallowing the severity of the impairment was greater for moderate and mild degrees. There was no statistical difference between the clinical and instrumental evaluation methods. However, there was a significant interaction between the variables, with a difference for liquid consistency in the instrumental evaluation method. Conclusion: Healthy elderly have different degree of swallowing impairment according to food consistency. The clinical assessment using a scale that considers the physiological changes of the elderly, presented results similar to those found in the instrumental examination. Level of Evidence: 2. Objective Methods crosssectional cross sectional 3 6 82 -8 years neurological diseases consistencies twoway two way ANOVA Tukeys Tukey s p< p (p 0.05. 005 0.05 . 0 05 0.05) Results degrees methods However variables method Conclusion examination Evidence 2 8 - 00 0.0 0.

RESUMO Este estudo analisou a relação entre o nível de estresse e a qualidade de vida de mulheres com câncer de mama, considerando distintos níveis de atividade física. Participaram da pesquisa 54 mulheres, entre 20 e 59 anos de idade, que estavam em tratamento ou que haviam terminado tratamento no período de 24 meses, oriundas do Centro de Saúde Integrativa da cidade do Rio de janeiro/RJ. Foram avaliados o nível de atividade física, o nível de estresse a qualidade de vida. A análise dos dados foi efetuada por meio da estatística descritiva e da estatística inferencial, com testes para avaliação das qualidades paramétricas das variáveis, além de testes para comparação de médias e de associação. As participantes apresentaram um nível de atividade física entre muito ativa e inativa, onde a metade das mulheres entrevistadas apresentaram o quadro de inatividade física. Em relação ao nível de estresse, as mulheres obtiveram uma média na escala de 19,0± 3,6 e 18,5± 4,0 independentemente do nível de atividade física. Os escores de estresse e qualidade de vida não foram alterados pelo nível de atividade física. Conclusão: As mulheres com câncer de mama apresentaram os sintomas do estresse elevados, característica frequente em consequência dos sintomas da patologia e exposição ao tratamento. Faz-se necessário, portanto, que sejam incorporadas mudanças no estilo de vida objetivando a redução do estresse e, consequentemente, uma melhora na QV.

ABSTRACT This study analyzed the relationship between the level of stress and the quality of life of women with breast cancer, considering different levels of physical activity. The participants were 54 women between 20 and 59 years old who were undergoing treatment underwent or completed treatment within 24 months from the Centre for Integrative Health in the city of Rio de Janeiro/RJ. Physical activity level, stress level, and quality of life were evaluated. Data analysis was performed using descriptive and inferential statistics, with tests to assess the parametric qualities of the variables, in addition to tests for comparing means and association. The participants showed a level of physical activity between very active and inactive, where half of the women interviewed showed physical inactivity. Regarding the stress level, the women obtained an average on the scale of 19.0± 3.6 e 18.5± 4.0 regardless of physical activity level. Stress and quality of life scores were not affected by physical activity level. Conclusion: Women with breast cancer had high-stress symptoms, a frequent characteristic because of the pathology symptoms and exposure to treatment. Therefore, it is necessary to incorporate changes in lifestyle to reduce stress and, consequently, improving quality of life.

RESUMO O estudo tem o objetivo de analisar fatos políticos produzidos pelo Poder Legislativo Federal com relação às políticas farmacêuticas no período de 2016 a 2020.Trata-se de um estudo explicativo, fundamentado em pesquisa documental, utilizando como fontes de dados os sites da Câmara dos Deputados e do Senado Federal, com o termo de busca ‘medicamento’. Foram incluídos quatro tipos de documentos (projetos de lei, projetos de lei complementar, medidas provisórias e propostas de Emenda à Constituição) referentes às políticas farmacêuticas, originadas no período de janeiro de 2016 a dezembro de 2020. A busca foi realizada por dois revisores, obtendo-se um total de 330 atos, organizados por meio da técnica de análise de conteúdo, em três categorias (assistência farmacêutica, regulação farmacêutica e controle sanitário de medicamentos), das quais analisou-se um fato político de cada uma. O Legislativo atuou de forma expressiva sobre as políticas farmacêuticas no período estudado, produzindo fatos políticos com interação de diferentes atores e que impactam no acesso a medicamentos e em seu uso racional.

ABSTRACT The study aimed to analyze the performance of the Federal Legislative Branch in relation to pharmaceutical policies in the period from 2016 to 2020. This is an explanatory study, based on documentary research, using as data sources the websites of the House of Representatives and the Federal Senate, with the search term ‘medicamento’. Four types of documents (bills, supplementary bills, provisional measures and proposed amendments to the Constitution) were included, referring to pharmaceutical policies, originated from January 2016 to December 2020. The search was performed by two reviewers, obtaining a total of 330 acts, organized, through the content analysis technique, into three categories (pharmaceutical assistance, pharmaceutical regulation and health control of medicines), of which one political fact from each was analyzed. The Legislative acted in an expressive way on pharmaceutical policies in the studied period, producing political facts with the interaction of different actors and that impact on access to medicines and on their rational use.

ABSTRACT: The physicochemical characterization, antioxidant potential and phenolic composition of fruits of six genotypes (BB3, BB4, BB6, PW1, PW2 and PW5) and seven commercial cultivars (Bluebelle, Bluegem, Briteblue, Climax, Delite, Powderblue and Woodard) were carried out of blueberry, from the 2019/2020 production cycle. Color, soluble solids content, pH, titratable acidity, antioxidant activity (DPPH and ABTS), total phenolic compounds, total flavonoids, total anthocyanins and individual anthocyanins were analyzed. In general, all genotypes and cultivars are rich in phytochemicals. The genotypes PW1, PW2, PW5, BB3 and the cultivars Bluegem, Briteblue, Climax and Delite stand out. Thus, the blueberry genotypes in this study are considered as promising for the food industry and also for fresh consumption as commercial cultivars already consolidated in the fruit market, in view of the excellent phenolic composition present in these small fruits. ABSTRACT characterization BB3, BB (BB3 BB4 BB6 PW1 PW PW5 Bluebelle, Bluebelle (Bluebelle Bluegem Briteblue Woodard 20192020 2019 2020 2019/202 cycle Color content pH acidity DPPH ABTS, ABTS , ABTS) compounds flavonoids analyzed general phytochemicals Thus market (BB 2019202 201 202 2019/20 201920 20 2019/2 20192 2 2019/

RESUMO: Fez-se a caracterização físico-química, potencial antioxidante e composição fenólica de frutos de seis genótipos (BB3, BB4, BB6, PW1, PW2 e PW5) e sete cultivares comerciais (Bluebelle, Bluegem, Briteblue, Climax, Delite, Powderblue e Woodard) de mirtileiro, oriundos do ciclo de produção 2019/2020. Analisou-se a cor, teor de sólidos solúveis, o pH, a acidez titulável, atividade antioxidante (DPPH e ABTS), compostos fenólicos totais, flavonoides totais, antocianinas totais e antocianinas individuais. De modo geral, todos os genótipos e cultivares são ricos em compostos fitoquímicos. Como destaque, estão os genótipos PW1, PW2, PW5, BB3 e as cultivares Bluegem, Briteblue, Climax e Delite. Assim, os genótipos de mirtileiro do presente estudo, são considerados tão promissores para a indústria alimentícia e também para o consumo in natura quanto as cultivares comerciais já consolidadas no mercado da fruticultura, tendo em vista a excelente composição fenólica presente nestes pequenos frutos. RESUMO Fezse Fez se físicoquímica, físicoquímica físico química, química físico-química BB3, BB (BB3 BB4 BB6 PW1 PW PW5 Bluebelle, Bluebelle (Bluebelle Bluegem Briteblue Delite Woodard 20192020 2019 2020 2019/2020 Analisouse Analisou cor solúveis pH titulável DPPH ABTS, ABTS , ABTS) individuais geral fitoquímicos destaque Assim estudo fruticultura (BB 2019202 201 202 2019/202 201920 20 2019/20 20192 2 2019/2 2019/

RESUMEN Objetivo: evaluar la viabilidad de la incorporación de la tecnología como una nueva alternativa para el tratamiento de temas sobre lesiones cervicales. Método: Se trata de un ensayo clínico aleatorizado, doble ciego, controlado y con un diseño prospectivo. Durante la realización de este estudio se incluyeron 43 mujeres divididas entre los grupos A (pomada sin nanopartículas de plata n = 23) y B (pomada con nanopartículas de plata n = 20) clínicamente sanas y usuarias del sistema unificado de salud. Resultados: No hubo diferencias significativas al comparar antes y después del uso de la pomada para la prueba de IVA (p = 0,15), la prueba de Schiller (p = 0,15), los cambios celulares (p = 0,47) y el análisis microbiológico (p = 0,89) mediante citología. Tras el uso, no se observó ninguna reacción adversa en la muestra estudiada. Conclusiones: Con base en los resultados identificados en este estudio, se identificó que el producto es seguro y no promueve eventos adversos. Con relación a la eficacia del producto en lesiones cervicales uterinas, es necesario continuar el estudio en fase II. Registro de Estudios Clínicos Brasileños: UTN: U1111-1218-2820. Objetivo Método aleatorizado ciego prospectivo 4 23 20 salud Resultados p 0,15, 015 0,15 , 0 15 0,15) 0,47 047 47 0,89 089 89 citología estudiada Conclusiones adversos uterinas II Brasileños UTN U111112182820. U111112182820 U U1111 1218 2820. 2820 U1111-1218-2820 2 01 0,1 1 0,4 04 0,8 08 8 U11111218282 U111 121 282 U1111-1218-282 0, U1111121828 U11 12 28 U1111-1218-28 U111112182 U1 U1111-1218-2 U11111218 U1111-1218- U1111121 U1111-1218 U111112 U1111-121 U11111 U1111-12 U1111-1 U1111-

ABSTRACT Objective: To assess the feasibility of incorporating technology as a new alternative for treating topics on cervical lesions. Method: This is a randomized, double-blind, controlled clinical trial with a prospective design. During the realization of this study, 43 women were included and divided between groups A (ointment without silver nanoparticles n = 23) and B (ointment with silver nanoparticles n = 20) clinically healthy and who used the unified health system. Results: There were no significant differences when comparing before and after the use of ointment for IVA test (p = 0.15), Schiller test (p = 0.15), cellular changes (p = 0.47) and microbiological analysis (p = 0.89) through cytology. After use, no adverse reaction was observed in the sample studied. Conclusion: Based on the results identified in this study, identified that the product is safe and does not promote adverse events. Regarding the effectiveness of the product in uterine cervical lesions, it is necessary to continue the study in phase II. Registro de Ensaios Clínicos Brasileiros: UTN: U1111-1218-2820. Objective lesions Method randomized doubleblind, doubleblind double blind, blind double-blind design 4 23 20 system Results p 0.15, 015 0.15 , 0 15 0.15) 0.47 047 47 0.89 089 89 cytology studied Conclusion events II Brasileiros UTN U111112182820. U111112182820 U U1111 1218 2820. 2820 U1111-1218-2820 2 01 0.1 1 0.4 04 0.8 08 8 U11111218282 U111 121 282 U1111-1218-282 0. U1111121828 U11 12 28 U1111-1218-28 U111112182 U1 U1111-1218-2 U11111218 U1111-1218- U1111121 U1111-1218 U111112 U1111-121 U11111 U1111-12 U1111-1 U1111-

RESUMO Objetivo: Avaliar a viabilidade da incorporação da tecnologia como uma nova alternativa para o tratamento de lesões cervicais. Método: Trata-se de um ensaio clínico randomizado, duplo-cego e controlado com um desenho prospectivo. Durante a realização deste estudo, foram incluídas 43 mulheres, divididas entre os grupos A (pomada sem nanopartículas de prata n = 23) e B (pomada com nanopartículas de prata n = 20), clinicamente saudáveis e usuárias do sistema único de saúde. Resultados: Não houve diferenças significativas na comparação entre antes e depois do uso da pomada para o teste IVA (p = 0,15), teste de Schiller (p = 0,15), alterações celulares (p = 0,47) e análise microbiológica (p = 0,89) por meio de citologia. Após o uso, não foi observada nenhuma reação adversa na amostra estudada. Conclusões: Com base nos resultados identificados neste estudo, identificou-se que o produto é seguro e não promove eventos adversos. Com relação à eficácia do produto em lesões cervicais uterinas, é necessária a continuidade do estudo na fase II. Registro de Ensaios Clínicos Brasileiros: UTN: U1111-1218-2820. Objetivo Método Tratase Trata se randomizado duplocego duplo cego prospectivo 4 mulheres 23 20, 20 , 20) saúde Resultados p 0,15, 015 0,15 0 15 0,15) 0,47 047 47 0,89 089 89 citologia estudada Conclusões identificouse identificou adversos uterinas II Brasileiros UTN U111112182820. U111112182820 U U1111 1218 2820. 2820 U1111-1218-2820 2 01 0,1 1 0,4 04 0,8 08 8 U11111218282 U111 121 282 U1111-1218-282 0, U1111121828 U11 12 28 U1111-1218-28 U111112182 U1 U1111-1218-2 U11111218 U1111-1218- U1111121 U1111-1218 U111112 U1111-121 U11111 U1111-12 U1111-1 U1111-