Abstract: The article, located in the field of the history of sport, aims to analyze the political activities of the three main sports and recreational Portuguese clubs and associations in São Paulo in the 1930s: Clube Português, Portugal Clube and Associação Portuguesa de Desportos. The main sources being constituted by the newspapers Correio Paulistano and Correio de S. Paulo, the study found that the mentioned institutions were integrated with each other and with other Portuguese associations, forming political networks that were expressed both by the articulation of joint actions and the interpersonal relationships between their leaderships. Abstract article sport 1930s s Português Desportos S leaderships

Resumo: O artigo, situado no campo da história do esporte, tem por objetivo analisar a atuação política dos três principais clubes e associações portuguesas de caráter esportivo e recreativo na São Paulo nos anos 1930: Clube Português, Portugal Clube e Associação Portuguesa de Desportos. Constituindo como fontes principais os jornais Correio Paulistano e Correio de S. Paulo, o estudo constatou que as instituições citadas integravam-se entre si e também com outras associações portuguesas, compondo redes de atuação política que se expressavam tanto na articulação de ações conjuntas como nas relações interpessoais entre suas lideranças. Resumo artigo esporte 1930 Português Desportos S integravamse integravam lideranças 193 19 1

Abstract Aiming to produce an antimicrobial dressing for wound healing applications, in this work Tea Tree oil (TTO) was incorporated into PHBV nanofibers by absorption. It was observed increase in the nanofiber diameter due to 5% TTO absorption efficiency, which also led to a 54% decrease in the contact angle. The releasing assay indicates a 6.8% oil release in the first 24 h – being probably the oil deposited at the polymer surface – followed by a minimal release at 48 h. The set of antimicrobial assays performed suggests the incorporation of TTO optimized the antimicrobial activity of the polymer for E. coli and C. albicans, while against S. aureus no significant difference was observed. The MTT assay showed no cytotoxicity of PHBV, but the incubation of L929 fibroblast cells with PHBV-TTO reduced cell viability. Overall, the PHBV nanofibers containing TTO present great potential as an antimicrobial dressing. applications (TTO 5 efficiency 54 angle 68 6 8 6.8 2 4 E C albicans S L L92 PHBVTTO viability Overall 6. L9

Abstract Background Diagnosis of SS is a complex task, as no symptom or test is unique to this syndrome. The American-European Consensus Group (AECG 2002) and the American-European classification criteria of 2016 (ACR/EULAR 2016) emerged through a search for consensus. This study aims to assess the prevalence of Sjögren’s Syndrome (SS) in patients with Systemic Lupus Erythematosus (SLE), according to AECG 2002 and ACR-EULAR 2016 classifications, as well as clinical and histopathological features in this overlap. To date, there is no study that has evaluated SS in SLE, using the two current criteria. Methods This cross-sectional study evaluated 237 SLE patients at the outpatient rheumatology clinic between 2016 and 2018. Patients were submitted to a dryness questionnaire, whole unstimulated salivary flow (WUSF), “Ocular Staining Score” (OSS), Schirmer’s test I (ST-I), and labial salivary gland biopsy (LSGB). Results After verifying inclusion and exclusion criteria, a total of 117 patients were evaluated, with predominance of females (94%) and mixed ethnicity (49.6%). The prevalence of SS was 23% according to AECG 2002 and 35% to ACR- EULAR 2016. Kappa agreement between AECG 2002 and ACR-EULAR 2016 were 0.7 (p < 0.0001). After logistic regression, predictors for SS were: anti/Ro (OR = 17.86, p < 0.05), focal lymphocytic sialadenitis (OR = 3.69, p < 0.05), OSS ≥ 5 (OR = 7.50, p < 0.05), ST I positive (OR = 2.67, p < 0.05), and WUSF ≤ 0.1 mL/min (OR = 4.13, p < 0.05). Conclusion The prevalence of SS in SLE was 23% (AECG 2002) and 35% (ACR-EULAR 2016). The presence of glandular dysfunction, focal lymphocytic sialadenitis, and anti/Ro were predictors of SS in SLE. The greatest advantage of the new ACR-EULAR 2016 criteria is to enable an early diagnosis and identify the overlapping of these two diseases. ACR- EULAR 2016 criteria is not yet validated for secondary SS and this study is a pioneer in investigating prevalence based on the new criteria. task syndrome AmericanEuropean American European 201 ACR/EULAR ACREULAR ACR consensus Sjögrens Sjögren s (SS , (SLE) 200 classifications overlap date crosssectional cross sectional 23 2018 questionnaire WUSF, (WUSF) Ocular Score OSS, (OSS) Schirmers Schirmer STI, STI (ST-I) LSGB. LSGB . (LSGB) 11 94% 94 (94% 49.6%. 496 49.6% 49 6 (49.6%) 35 07 0 7 0. 0.0001. 00001 0.0001 0001 0.0001) regression antiRo anti Ro OR 1786 17 86 17.86 0.05, 005 0.05 05 0.05) 369 3 69 3.69 750 50 7.50 267 2 67 2.67 01 1 mLmin mL min 413 4 13 4.13 0.05. dysfunction diseases 20 (SLE (WUSF (OSS (ST-I (LSGB 9 (94 49.6 (49.6% 0000 0.000 000 178 8 17.8 00 0.0 36 3.6 75 7.5 26 2.6 41 4.1 (9 49. (49.6 0.00 17. 3. 7. 2. 4. ( (49. (49 (4

Abstract This work is a floristic study of Selaginella in Maranhão. The species survey is based on collections from fieldwork conducted between April 2006 and February 2023 and specimens from Maranhão deposited at the CCAA, HBRA, MG, and SLUI herbaria. Ten species were identified: Selaginella conduplicata, S. convoluta, S. erythropus, S. flagellata, S. gynostachya S. marginata, S. minima, S. radiata, S. simplex, and S. sulcata. We report the first record of S. gynostachya for Maranhão and the Cerrado domain in Brazil. Until now, this species was only known from areas of Amazonia. We provide a map with records, an identification key, and comments about the identification and geographic distribution of Selaginella species in Maranhão state. For the new record, we also provide photos. 200 202 CCAA HBRA MG herbaria identified conduplicata S convoluta erythropus flagellata marginata minima radiata simplex sulcata Brazil now Amazonia records key state photos 20 2

Resumo O presente trabalho trata do estudo florístico de Selaginella no Maranhão. O levantamento de espécies foi realizado com base em coletas de campo realizadas entre abril de 2006 e fevereiro de 2023 e em análise de espécimes coletados no Maranhão e depositadas nos herbários CCAA, HBRA, MG e SLUI. Foram identificadas 10 espécies: Selaginella conduplicata, S. convoluta, S. erythropus, S. flagellata, S. gynostachya S. marginata, S. minima, S. radiata, S. simplex e S. sulcata. Relatamos a primeira ocorrência de S. gynostachya para o Maranhão e também para o domínio do Cerrado Brasileiro. Até então essa espécie era registrada somente em áreas amazônicas. Neste artigo apresentamos um mapa com pontos de coleta, uma chave de identificação e comentários sobre a identificação, ecologia e distribuição geográfica para as espécies de Selaginella do Maranhão. Para o novo registro apresentamos também fotos. 200 202 CCAA HBRA SLUI 1 conduplicata S convoluta erythropus flagellata marginata minima radiata sulcata Brasileiro amazônicas coleta fotos 20 2

Introduction: Analysis of the outcome of 268 ICU patients in a single-center, as well the impact of viral infection on patients with preexisting medical conditions and how these factors affected survival and hospital stay. Methodology: Patients admitted to the ICU from March-August, 2020 were retrospectively analyzed under the same protocol at Hospital Alemão Oswaldo Cruz, São Paulo, Brazil. Several factors were considered and the results were presented using 95% confidence intervals. For statistical significance, p &lt;0.05 was adopted. Results: Patient median age was 72 years, 64,2 years for discharged patients and 79.9 years for those deceased (p&lt;0.001). The most common comorbidities were: systemic arterial hypertension, diabetes, thyroid disease, cardiovascular and kidney disease. Predictors of survival through univariate analysis: myalgia (p=0.001), cerebrovascular disease (p=0.002), COPD (p=0.003), dementia (p=0.000), mechanical ventilation (p=0.000), dialysis (0.000), vasopressor use (0.000), SAPS3 (0.000), lymphopenia (p=0.004), elevated D-dimer (P=0.011), time in ICU before tracheostomy (p=0.002), and performing a tracheostomy (p=0.000). The independent predictors of mortality were: advanced age (p=0.003) and tracheostomy performed in ICU (p=0.002). Discussion: COVID-19 affects usually older adults, where there already is a higher fatality rate. Acute respiratory distress syndrome is the primary cause of death and &lt;5% of patients were reported as experiencing co-infection at admission. Conclusion: age, vasopressor use in patients with tracheostomy, and systemic coronary disease, heart failure, neoplasia, and COPD, were found to be significantly associated with COVID-19 severity.

Abstract Background: The Coronavirus 19 (COVID-19) pandemic has dramatically impacted liver organ transplantation. The American Society of Transplantation recommends a minimum of 28 days after symptom resolution for organ donation. However, the exact time for transplantation for recipients is unknown. Considering that mortality on the waiting list for patients with MELD >25 or fulminant hepatitis is higher than that of COVID-19, the best time for surgery after SARS-CoV-2 infection remains undetermined. This study aims to expand the current knowledge regarding the Liver Transplantation (LT) time for patients after COVID-19 and to provide transplant physicians with essential decision-making tools to manage these critically ill patients during the pandemic. Methods: Systematic review of patients who underwent liver transplantation after diagnosis of COVID-19. The MEDLINE, PubMed, Cochrane, Lilacs, Embase, and Scielo databases were searched until June 20, 2021. The MESH terms used were “COVID-19” and “Liver transplantation”. Results: 558 articles were found; of these 13 articles and a total of 18 cases of COVID-19 prior to liver transplantation were reported. The mean age was 38.7±14.6, with male prevalence. Most had mild symptoms of COVID. Five patients have specific treatment for COVID-19 with convalescent plasm or remdesivir/oseltamivir, just one patient received hydroxychloroquine, and 12 patients received only symptomatic treatment. The median time between COVID-19 to LT was 19 days (13.5-44.5). Deceased donor liver transplantation accounted for 61% of cases, while living donor transplantation was 39%. Conclusion: Despite the concerns regarding the postoperative evolution, the mortality of patients with high MELD or fulminant hepatitis transplanted shortly after COVID-19 diagnosis does not seem to be higher. (PROSPERO, registration number = CRD42021261790)

ABSTRACT Vaccination is a fundamental tool to prevent SARS-CoV-2 infection and to limit the COVID-19 pandemic. The emergence of SARS-CoV-2 variants with multiple mutations has raised serious concerns about the ability of neutralizing antibody responses elicited by prior vaccination to effectively combat these variants. The neutralizing capacity against the Gamma, Delta and Omicron variants of sera from individuals immunized with the CoronaVac vaccine remains incompletely determined. The present study evaluated 41 health care workers at the Faculdade de Medicina of the Universidade de Sao Paulo, in Sao Paulo, Brazil, naive to previous SARS- CoV-2 infection, who were vaccinated with two doses of the CoronaVac SARS-CoV-2 vaccine 28 days apart. Neutralizing antibody levels against the Gamma, Delta, and Omicron variants were measured at 32 and 186 days after the second vaccination. We also measured neutralizing antibodies against Omicron in 34 of these individuals following a subsequent booster immunization with the Pfizer vaccine. Quantification of neutralizing antibodies was performed using the Cytopathic Effect-based Virus Neutralization test. Neutralization antibody activity against the Gamma, Delta and Omicron variants was observed in 78.0%, 65.9% and 58.5% of serum samples, respectively, obtained at a mean of 32 days after the second immunization. This decreased to 17.1%, 24.4% and 2.4% of sera having activity against Delta, Gamma and Omicron, respectively, at 186 days post-vaccination. The median neutralizing antibody titers at 32 days were 1:40, 1:20 and 1:20 against Gamma, Delta and Omicron, respectively, and decreased to an undetectable median level against all variants at the later time. A booster immunization with the Pfizer vaccine elicited neutralizing antibodies against Omicron in 85% of subjects tested 60 days after vaccination. We conclude that two doses of the CoronaVac vaccine results in limited protection of short duration against the Gamma, Delta and Omicron SARS-CoV-2 variants. A booster dose with the Pfizer vaccine induced antibody neutralizing activity against Omicron in most patients which was measurable 60 days after the booster.

Abstract Pure titanium and various alloys, such as Ti-6Al-4V, are widely used as biomaterials. In this application, surface finish conditions, topography, and surface reactivity determine excellent cellular adhesion and osseointegration characteristics. The study evaluated the influence of four surface finishing treatments (sanding #120, 600, 1200, and polished with 3 µm alumina paste) and three shapes (concave, convex, and flat) on the corrosion resistance of Ti-6Al-4V at 37 °C in simulated body fluid (SBF) through potentiodynamic polarization and electrochemical impedance spectroscopy. The SBF's ionic composition allowed the formation of a stable passive layer with a low presence of pores on the surface. In addition, the combination of polished surface and convex shape showed the best electrochemical passive behavior.

RESUMO Objetivo: Investigar picos de pressão intraocular em pacientes fácicos e pseudofácicos com glaucoma primário de ângulo aberto no teste de sobrecarga hídrica. Método: Quarenta pacientes com glaucoma primário de ângulo aberto foram avaliados; vinte eram fácicos e vinte eram pseudofácicos. Um olho (selecionado aleatoriamente) foi incluído no estudo, todos os pacientes foram submetidos às curvas da pressão intraocular imediatamente após o teste de sobrecarga hídrica. Resultados: Observou-se uma diferença estatisticamente significante na média dos picos nas curvas da pressão intraocular para os pacientes fácicos e pseudofácicos (p=0,045). Houve diferença estatisticamente significante nos picos da pressão intraocular no teste de sobrecarga hídrica entre os grupos, sendo observados valores mais altos nos pacientes fácicos (p=0,004). Conclusão: Os picos da pressão intraocular no teste de sobrecarga hídrica foram maiores no grupo fácico que no grupo pseudofácico.

ABSTRACT Purpose: To investigate intraocular pressure peaks in phakic and pseudophakic patients with primary open-angle glaucoma. Method: Overall, 40 patients with primary open-angle glaucoma were assessed. Of these, 20 patients were phakic and 20 pseudophakic. One eye (randomly selected) was included in the study. All patients underwent the intraocular pressure curves test, followed by the water-drinking test. Results: A statistically significant difference was observed between the phakic and pseudophakic patients regarding the mean of the peaks in the intraocular pressure curves (p=0.045). A statistically significant intergroup difference was noted regarding the intraocular pressure peaks in the water-drinking test, with higher values observed in the phakic patients (p 0.004). Conclusion: The intraocular pressure peaks in the water-drinking test and intraocular pressure curves were higher in the phakic group than in the pseudophakic group.

ABSTRACT Objective: Adipose tissue-derived stromal/stem cells (ASCs) and vitamin D have immunomodulatory actions that could be useful for type 1 diabetes (T1D). We aimed in this study to investigate the safety and efficacy of ASCs + daily cholecalciferol (VIT D) for 6 months in patients with recent-onset T1D. Materials and methods: In this prospective, dual-center, open trial, patients with recent onset T1D received one dose of allogenic ASC (1 x 106 cells/kg) and cholecalciferol 2,000 UI/day for 6 months (group 1). They were compared to patients who received chol-ecalciferol (group 2) and standard treatment (group 3). Adverse events were recorded; C-peptide (CP), insulin dose and HbA1c were measured at baseline (T0), after 3 (T3) and 6 months (T6). Results: In group 1 (n = 7), adverse events included transient headache (all), mild local reactions (all), tachycardia (n = 4), abdominal cramps (n = 1), thrombophlebitis (n = 4), scotomas (n = 2), and central retinal vein occlusion at T3 (n = 1, resolution at T6). Group 1 had an increase in basal CP (p = 0.018; mean: 40.41+/-40.79 %), without changes in stimulated CP after mixed meal (p = 0.62), from T0 to T6. Basal CP remained stable in groups 2 and 3 (p = 0.58 and p = 0.116, respectively). Group 1 had small insulin requirements (0.31+/- 0.26 UI/kg) without changes at T6 (p = 0.44) and HbA1c decline (p = 0.01). At T6, all patients (100%; n = 7) in group 1 were in honeymoon vs 75% (n = 3/4) and 50% (n = 3/6) in groups 2 and 3, p = 0.01. Conclusions: Allogenic ASC + VIT D without immunosuppression was safe and might have a role in the preservation of β-cells in patients with recent-onset T1D. ClinicalTrials.gov: NCT03920397.

ABSTRACT Objective: Choosing Wisely (CW) is an initiative that aims to advance the dialogue between physicians and patients about low-value health interventions. Given that thyroid conditions are frequent in clinical practice, we aimed to develop an evidence-based list of thyroid CW recommendations. Materials and methods: The Thyroid Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) named a Task Force to conduct the initiative. The Task Force work was based on an electronic Delphi approach. The 10 recommendations that received the highest scores by the Task Force were submitted for voting by all SBEM associates. The 5 recommendations that received the highest scores by SBEM associates are presented herein. Results: The Task Force was composed of 14 thyroidologists from 10 tertiary-care, teaching-based Brazilian institutions. The brainstorming/ideation phase resulted in 69 recommendations. After the removal of duplicates and recommendations that did not adhere to the initiative's scope, 35 remained. Then the Task Force voted to attribute a grade (0 [lowest agreement] to 10 [highest agreement]) for each recommendation. The 10 recommendations that received the highest scores by the Task Force were submitted to all SBEM associates. A total of 683 associates voted electronically, attributing a grade (0 to 10) for each recommendation. The 5 recommendations that received the highest scores by the SBEM associates compose our final list. Conclusion: A set of recommendations to avoid unnecessary medical tests, treatments, or procedures for thyroid conditions are offered with a transparent methodology. This initiative aims to foster productive interactions between physicians and patients, stimulating shared decision-making.

abstract background: the recovery of areas impacted by mining activities is a major challenge and requires knowledge of how the biological and biochemical processes of the soil as well as the establishment of plant species are affected by mining residue. in this work, the influence of deposition of iron mining mud and tailings on soil biochemical attributes and the initial development of tree seedlings was studied in a simulated event in the greenhouse. pots (n = 27) with natural soil (2.0 kg) received deposition (280 ml) of iron mining mud or tailings and by three-month was cultivated with urochloa decumbens. at the end of this period, part of the pots was sampled and the soil biochemical activities were evaluated. then tree seedlings (schinus terebinthifolius and eremanthus incanus) were planted and cultivated for a year, when then shoot (sdw) and roots (rdw) dry weight were evaluated. results: deposition of iron mining mud and tailings did not affect microbial biomass carbon or basal soil respiration, however both conditions reduced (p < 0.05) β-glucosidase activities by up to 30%, and the easy extractable glomalin by about 19%. in addition, the mud deposition reduced (p < 0.05) the sdw and rdw of s. terebinthifolius by about 21% and 24%, respectively. nevertheless, uruchloa decumbens and eremanthus incanus had no variation in dry weight production between treatments, so they have good ability to grow settle in soil affected by mining residue. conclusion: this study shows that the sequential planting of u. decumbens and e. incanus can be an alternative for use in environments with deposition of iron mining tailings.

Resumo O gênero Setaria é mundialmente conhecido parasitando mamíferos selvagens e domésticos, sendo registradas 43 espécies, das quais cinco ocorrem no continente americano. Este estudo objetivou caracterizar a ocorrência, morfologia e morfometria de S. labiatopapillosa em B. taurus e B. bubalis na Ilha de Marajó, Brasil. Foram realizadas inspeções de carcaça de 420 bovinos em dois abatedouros no Pará. Os nematódeos foram encontrados sobre as vísceras brancas e serosa do intestino delgado, sendo limpos e conversados para análise por microscopia de luz e microscopia eletrônica de varredura. As características morfológicas e morfométricas são compatíveis com S. labiatopapillosa parasitando ambas as espécies, com prevalência de 25% (B. bubalis) e 24% (B. taurus). Informações obtidas por microscopia eletrônica de varredura foram adicionadas à descrição da espécie, além de ampliar a distribuição desse parasito no território nacional.

Abstract The genus Setaria is known worldwide for parasiting wild and domestic mammals, with 43 species registered, of which five occur in the American continent. The objective of this study was to characterize the occurrence, morphology and morphometry of S. labiatopapillosa in B. taurus and B. bubalis in Marajó Island, Brazil. Carcass inspections of 420 cattle were carried out in two slaughterhouses in Pará. The nematodes were found on the white and serous viscera of the small intestine, being cleaned and discussed for analysis by light microscopy and scanning electron microscopy. The morphological and morphometric characteristics are compatible with S. labiatopapillosa parasitizing both species, with a prevalence of 25% (B. bubalis) and 24% (B. taurus). Information obtained by scanning electron microscopy was added to the description of the species, in addition to expanding the distribution of this parasite in the national territory.

Abstract The aim of this study is to investigate if Sargassum-associated herbivorous amphipods Cymadusa filosa Savigny, 1816 and Sunamphitoe pelagica (H. Milne Edwards, 1830) present differences in their population parameters at sites located at different distances from a state marina, which is the main source of pollution (especially heavy metals) in an impacted bay. The study was conducted at four beach sites within Flamengo Bay, Ubatuba municipality, northern coast of São Paulo State, Brazil. The beaches are Lamberto and Ribeira close to the pollution source and Flamengo and Santa Rita, which are more distant. We observed the predominance of juveniles in the populations of C. filosa and S. pelagica, followed by females, with the sex ratio for both species being favored toward females, and the highest densities of individuals were observed during the summer. Sunamphitoe pelagica presented lower density, smaller ovigerous females and egg volumes at Lamberto beach, indicating a possible higher sensitivity to metal pollution for this species. Cymadusa filosa showed no clear alteration of density, number of ovigerous females and egg volumes between sites. Our results emphasize the importance of studying the life history and reproductive parameters of herbivorous amphipods, showing how these parameters can be altered in contaminated areas.