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Resumo Uma lista de peixes recentes e fósseis da Ordem Characiformes é apresentada e acredita-se que a lista esteja completa até 2022. Ao todo, 47 colaboradores verificaram e forneceram informações sobre táxons de sua especialidade. A lista está organizada em ordem alfabética por família e em seguida gênero e inclui todos os sinônimos disponíveis. De um total de 3.087 nomes de grupos de espécies e 527 nomes de grupos de gêneros, 2.334 espécies são atualmente tratadas como válidas e atribuídas a 301 gêneros e 24 famílias. Este total inclui 25 espécies fósseis, das quais 21 são incluídas em oito famílias recentes e quatro são Incertae sedis em Characiformes, mas não inclui cinco espécies baseadas em fósseis que foram incorretamente consideradas como Characiformes. O status de 79 espécies nominais permanece não resolvido. Quando há duas hipóteses concorrentes sobre a validade de um nome, uma delas é escolhida e a interpretação alternativa é fornecida na seção de comentários do nome em questão. Dados sobre distribuição geográfica são apresentados através de números que correspondem a regiões para as quais há registro de ocorrência da espécie. Uma lista de nomes indisponíveis foi listada no final do texto, pois alguns desses nomes precisam ser mais bem investigados para certificar seu status. acreditase acredita se 2022 todo 4 especialidade disponíveis 3087 3 087 3.08 52 2334 2 334 2.33 30 7 resolvido questão espécie texto 202 308 08 3.0 5 233 33 2.3 20 0 3. 23 2.

Abstract A checklist of recent and fossil fishes of the Order Characiformes is presented herein and believed to be complete through 2022. A total of 47 collaborators checked and provided information about their taxa of expertise. The list is arranged in alphabetical order by family and then genus and includes all available synonyms. From a total of 3,087 species group names and 527 genus group names, 2,334 species are currently treated as valid, and assigned to 301 genera and 24 families. This total includes 25 species known only from the fossil record, of which 21 are assigned to eight extant families and four are Incertae sedis in Characiformes, but does not include five species based on fossil which were wrongly treated in Characiformes. The status of 79 nominal species remains unresolved. When there are two competing hypotheses about the validity of a name, one of them is chosen and the alternate interpretation is provided in the remark section of that name. Distributional summaries are presented as numbers that correspond to areas for which there is a record of occurrence of the species. A list of unavailable names is provided at the end since some of those names may need additional research to certify their status. 2022 4 expertise synonyms 3087 3 087 3,08 52 2334 2 334 2,33 valid 30 7 unresolved name 202 308 08 3,0 5 233 33 2,3 20 0 3, 23 2,

https://doi.org/10.1590/1982-0224-2023-0086

Suplementação de Vitamina D Induz Remodelação Cardíaca em Ratos: Associação com a Proteína de Interação com a Tiorredoxina e a Tiorredoxina
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Santos, Priscila P. dos

; Rafacho, Bruna P. M.

; Gonçalves, Andrea F.

; Pires, Vanessa C. M.

; Roscani, Meliza G.

; Azevedo, Paula S.

; Polegato, Bertha F.

; Minicucci, Marcos F. Fernandes, Ana Angélica H. Tanni, Suzana E. Zornoff, Leonardo A. M. Paiva, Sergio A. R. de

Arquivos Brasileiros de Cardiologia

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Nov 2021, Volume 116 Nº 5 Páginas 970 - 978

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A vitamina D (VD) tem um importante papel na função cardíaca. No entanto, a vitamina exerce uma curva “dose-resposta” bifásica na fisiopatologia cardiovascular e pode causar efeitos deletérios, mesmo em doses não tóxicas. A VD exerce suas funções celulares ligando-se ao seu receptor. Ainda, a expressão da proteína de interação com a tiorredoxina (TXNIP) é positivamente regulada pela VD. A TXNIP modula diferentes visa de sinalização celular que podem ser importantes para a remodelação cardíaca. Objetivos: Avaliar se a suplementação com VD leva à remodelação cardíaca, e se a TXNIP e a tiorredoxina (Trx) estão associadas com esse processo. Métodos: Duzentos e cinquenta ratos Wistar machos foram alocados em três grupos: controle (C, n=21), sem suplementação com VD; VD3 (n = 22) e VD10 (n=21), suplementados com 3,000 e 10,000 UI de VD/ kg de ração, respectivamente, por dois meses. Os grupos foram comparados por análise de variância (ANOVA) com um fator e teste post hoc de Holm-Sidak (variáveis com distribuição normal), ou pelo teste de Kruskal-Wallis e análise post-hoc de Dunn. O nível de significância para todos os testes foi de 5%. Resultados: A expressão de TXNIP foi mais alta e a atividade do Trx foi mais baixa no grupo VD10. Os animais que receberam suplementação com VD apresentaram aumento de hidroperóxido lipídico e diminuição de superóxido dismutase e glutationa peroxidase. A proteína Bcl-2 foi mais baixa no grupo VD10. Observou-se uma diminuição na β-oxidação de ácidos graxos, no ciclo do ácido tricarboxílico, na cadeia transportadora de elétrons, e um aumento na via glicolítica. Conclusão: A suplementação com VD levou à remodelação cardíaca e esse processo pode ser modulado por TXNIP e Trx, e consequentemente por estresse oxidativo.

Abstract Background: Vitamin D (VD) has been shown to play an important role in cardiac function. However, this vitamin exerts a biphasic “dose response” curve in cardiovascular pathophysiology and may cause deleterious effects, even in non-toxic doses. VD exerts its cellular functions by binding to VD receptor. Additionally, it was identified that the thioredoxin-interacting protein (TXNIP) expression is positively regulated by VD. TXNIP modulate different cell signaling pathways that may be important for cardiac remodeling. Objective: To evaluate whether VD supplementation lead to cardiac remodeling and if TXNIP and thioredoxin (Trx) proteins are associated with the process. Methods: A total of 250 Male Wistar rats were allocated into three groups: control (C, n=21), with no VD supplementation; VD3 (n = 22) and VD10 (n=21), supplemented with 3,000 and 10,000 IU of VD/ kg of chow respectively, for two months. The groups were compared by one-way analysis of variance (ANOVA) and Holm-Sidak post hoc analysis, (variables with normal distribution), or by Kruskal-Wallis test and Dunn's test post hoc analysis. The significance level for all tests was 5%. Results: TXNIP protein expression was higher and Trx activity was lower in VD10. The animals supplemented with VD showed increased lipid hydroperoxide and decreased superoxide dismutase and glutathione peroxidase. The protein Bcl-2 was lower in VD10. There was a decrease in fatty acid β-oxidation, tricarboxylic acid cycle and electron transport chain with shift to increase in glycolytic pathway. Conclusion: VD supplementation led to cardiac remodeling and this process may be modulated by TXNIP and Trx proteins and consequently oxidative stress.

https://doi.org/10.36660/abc.20190633 352 downloads

Influência do Consumo de Suco de Laranja (Citrus Sinensis) na Remodelação Cardíaca de Ratos Submetidos a Infarto do Miocárdio
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Oliveira, Bruna C.

; Santos, Priscila P.

; Figueiredo, Amanda M.

; Rafacho, Bruna P. M.

; Ishikawa, Larissa

; Zanati, Silméia G.

; Fernandes, Ana A. H.

; Azevedo, Paula S. Polegato, Bertha F. Zornoff, Leonardo A. M. Minicucci, Marcos F. Paiva, Sergio A. R.

Arquivos Brasileiros de Cardiologia

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Jun 2021, Volume 116 Nº 6 Páginas 1127 - 1136

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento O suco de laranja (SL) é rico em polifenóis com propriedades anti-inflamatórias e antioxidantes. Após o infarto do miocárdio (IM), mudanças complexas ocorrem na estrutura e na função cardíacas, processo conhecido como remodelação cardíaca (RC). O estresse oxidativo e a inflamação podem modular esse processo. Nossa hipótese foi a de que o consumo de SL atenua a RC após o IM. Objetivos Avaliar a influência do SL sobre a RC após IM pela análise de variáveis funcionais, morfológicas, de estresse oxidativo, de inflação, e de metabolismo energético. Métodos Um total de 242 ratos machos pesando entre 200 e 250g foram submetidos a um procedimento cirúrgico (ligação da artéria coronária ou cirurgia simulada). Sete dia após a cirurgia, os animais sobreviventes foram divididos para um dos quatro grupos: 1) SM, animais sham que receberam água e maltodextrina (n= 20); 2) SSL, animais sham que receberam SL (n= 20); 3) IM, animais infartados que receberam água e maltodextrina (n= 40); e 4) ISL, animais infartados que receberam SL (n = 40). A análise estatística foi realizada pelo teste de ANOVA com dois fatores com o teste de Holm-Sidak. Os resultados foram apresentados em média ± desvio padrão, e o nível de significância adotado foi de 5%. Resultados Três meses depois, o IM levou à hipertrofia do ventrículo esquerdo (VE), com disfunção sistólica e diastólica, e aumento nos mediadores inflamatórios e de estresse oxidativo. Os animais que consumiram SL apresentaram menor atividade da glutationa peroxidase e maior expressão da heme-oxigenase-1 (HO-1). Conclusão O SL atenuou a RC, e a HO-1 pode exercer um importante papel nesse processo.

Abstract Background Orange juice (OJ) is rich in polyphenols with anti-inflammatory and antioxidant properties. After myocardial infarction (MI), complex changes occur in cardiac structure and function, which is known as cardiac remodeling (CR). Oxidative stress and inflammation can modulate this process. We hypothesized that the consumption of OJ attenuates the CR after MI. Objectives To evaluate the influence of OJ on CR after MI by analysis of functional, morphological, oxidative stress, inflammation, and energy metabolism variables. Methods A total of 242 male rats weighing 200-250 g were submitted to a surgical procedure (coronary artery ligation or simulated surgery). Seven days after surgery, survivors were assigned to one of the four groups 1) SM, sham animals with water and maltodextrin (n= 20); 2) SOJ, sham animals with OJ (n= 20); 3) IM, infarcted animals with water and maltodextrin (n= 40); and 4) IOJ, infarcted animals with OJ (n = 40). Statistical analysis was performed by the two-way ANOVA supplemented by Holm-Sidak. Results are presented as mean ± standard deviation, the level of significance adopted was 5%. Results After 3 months, MI led to left ventricular (LV) hypertrophy, with systolic and diastolic dysfunction, and increased oxidative stress and inflammatory mediators. OJ intake reduced LV cavity and improved systolic and diastolic function. The OJ animals presented lower activity of glutathione peroxidase and higher expression of heme-oxygenase-1 (HO-1). Conclusion OJ attenuated CR in infarcted rats and HO-1 may be play an important role in this process.

https://doi.org/10.36660/abc.20190397 272 downloads

Astaxanthin Recovery from Shrimp Residue by Solvent Ethanol Extraction Using Choline Chloride:Glycerol Deep Eutectic Solvent as Adjuvant
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Santos, Cleidijane A. dos

; Padilha, Carlos E. A.

; Damasceno, Karla S. F. S. C. Leite, Pedro I. P. Araújo, Ana C. J. de Freitas, Priscila R. Vieira, Érica A. Cordeiro, Angela M. T. M. Sousa Jr., Francisco C. de Assis, Cristiane F. de

Journal of the Brazilian Chemical Society

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Mai 2021, Volume 32 Nº 5 Páginas 1030 - 1039

Resumo: En | Texto: En | PDF: En

The present study investigated the use of choline chloride:glycerol deep eutectic solvent as an adjuvant for tuning the ethanol extraction of astaxanthin from Litopenaeus vannamei processing residues. The adjuvant concentration did not show a clear trend on the total carotenoid, however, the addition of adjuvant proved to be advantageous in the ultrasound-assisted experiments. In order to establish a balance between total carotenoid and productivity, an operational condition with ultrasound, 5% (m/v) choline chloride:glycerol and 10 min of incubation was selected, which provided 737.69 µg g-1 total carotenoids and 32.71 µg g-1 astaxanthin. When compared to the astaxanthin standard, the shrimp residue extract obtained greater antioxidant activity in free radical scavenging tests. In addition, the shrimp residue extract dramatically reduced the dosage of norfloxacin (up to 87.5%) and gentamicin (up to 75.0%) antibiotics in tests to inhibit the growth of Gram-negative bacteria.

https://doi.org/10.21577/0103-5053.20210005 173 downloads

Inhibition of Acetylcholinesterase by Coumarin-Linked Amino Acids Synthetized via Triazole Associated with Molecule Partition Coefficient
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Sousa, Bianca L. de

; Leite, João P. V.

; Mendes, Tiago A. O.

; Varejão, Eduardo V. V.

; Chaves, Anna C. S. Silva, Júnio G. da Agrizzi, Ana P. Ferreira, Priscila G. Pilau, Eduardo J. Silva, Evandro Santos, Marcelo H. dos

Journal of the Brazilian Chemical Society

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Mar 2021, Volume 32 Nº 3 Páginas 652 - 664

Resumo: En | Texto: En | PDF: En

A previous study for the identification of acetylcholinesterase (AChE) inhibitors demonstrated that the hybrid between tyrosol, the 1,2,3-triazole nucleus, and the coumarin group, namely 7-({1-[2-(4-hydroxyphenyl)ethyl]-1H-1,2,3-triazol-4-yl}methoxy)-4-methyl-2H-chromen-2-one (10), has a high enzyme inhibitory activity. Here, we synthesized analogues of 10 via triazole with pharmacophoric groups represented by tyrosine, phenylalanine, tryptophan, and glycine in addition to evaluating the impact of coumarin-linked amino acids on AChE inhibition. We obtained eight triazoles, six of which are undescribed. In general, the presence of carboxylic acid decreased the inhibitory activity, while aromatic amino acids increased enzymatic inhibition compared to glycine. The derivative containing tyrosine, structurally most similar to 10, presented the lowest inhibition percentage, indicating that phenolic hydroxyl is not the preponderant factor for inhibition. Molecular docking was not enough to explain in vitro experiments. On the other hand, MlogP (logP calculated by the Moriguchi method) was related positively to enzymatic inhibition. To increase the hydrophobicity of the molecules, we tested the esterified triazole derivatives comparatively with the enzyme. The compound ethyl 2-(4-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)acetate (6) presented an increment of inhibitory activity of 46.97 ± 1.75% at 100 μmol L-1. We also associated the best activity with the lowest van der Waals volume and molar mass values.

https://doi.org/10.21577/0103-5053.20200219 184 downloads

High-concentrate diets with fibrous by-products for feedlot Nellore heifers
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CLEEF, ERIC H.C.B. VAN

; OLIVEIRA, PRISCILA S.N. DE

; GALATI, ROSEMARY LAÍS

; FERREIRA, DANIEL S.

; SANTOS, VIVIANE C.

; HOMEM JUNIOR, ANTÔNIO CARLOS

; PEREIRA JUNIOR, SERGIO ANTÔNIO G.

; PARDO, RENÉ MAURICIO P.

; EZEQUIEL, JANE MARIA B.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 3 elocation e20190731

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to evaluate high-concentrate diets and two energy sources on intake, performance and meat quality parameters of feedlot Nellore heifers. Twenty-eight heifers (200 ± 22.5 kg BW) were randomly assigned to four treatments in a 2×2 factorial arrangement: two concentrate levels (70 and 80%) and two energy sources (corn and corn germ meal). At the end of day 112, heifers were slaughtered. There was no interaction (P>0.05) of concentrate levels and energy sources for dry matter intake, unlike crude protein (CP) and neutral detergent fiber (NDF) intakes. The concentrate level of 80% and corn, allowed the highest CP (1.17 kg/day) and NDF (4.05 kg/day) intakes. Final BW (P<0.05) and daily gain (P<0.01) were influenced just by energy source. The carcass composition represented by muscle and fat was affected by concentrate level (P<0.05). Treatments affected (P<0.01) carcass fat deposition, global preference and texture of Longissimus muscle (P<0.05). It was concluded that high proportions of concentrate containing corn as energy source provided the best performance in heifers, and that the total replacement of corn with corn germ meal in high-concentrate diets is not recommended for performance Nellore heifers, but provided good sensory quality to the meat.

https://doi.org/10.1590/0001-3765202120190731 379 downloads

Composition and structure of the bryophyte community of Park Savanna in Marajó Island, Pará, Brazil
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GOMES, PAULO W.P.

; MEDEIROS-SARMENTO, PRISCILA S. DE

; SANTOS, RITA DE CÁSSIA P. DOS

; TAVARES-MARTINS, ANA CLÁUDIA C.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 2 elocation e20190830

Resumo: En | Texto: En | PDF: En

Abstract Aiming to enrich the knowledge about the flora of savannas, this paper studied the composition and structure of the bryophyte community of Park Savanna areas in Marajó Island - PA. Biological material was collected within 60 100-m2 plots equally distributed in the dry season of 2016 and the rainy season of 2017 in five Park Savanna areas (SP-I to SP-V). The composition, density, richness and diversity of species and presence of indicator species were compared between the sampled areas and seasons. The species were classified according to the substrates colonized and ecological groups of light tolerance. Significant differences in SP-V indicated that the area was the main factor influencing the composition of bryophytes (p: 0.0001), with five indicator species. There were also significant differences in density (p = 0.0001168) and richness (p = 0.0001317) of bryophytes between seasons (p-value = 0.3393; p-value = 0.04065; p: 0.1081). There was a predominance of generalist (25 spp.) and corticolous (728 individuals) species, which were widely distributed in the sampled areas. Therefore, the structure of the bryophyte communities was not influenced by seasonality, and this indicates that these plants are adapted to the environmental conditions.

https://doi.org/10.1590/0001-3765202120190830 177 downloads

Clinical and anatomopathological study of urolithiasis in feedlot lambs subjected to diets with different phosphorus concentrations
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Santarosa, Bianca Paola

; Ferreira, Danilo Otávio Laurenti

; Surian, Soraya Regina Sacco

; Tremori, Tália Missen

; Hooper, Henrique Barbosa

; Silva, Priscila dos Santos

; Coelho, Matheus Ribeiro

; Santos, Vítor Hugo dos

; Gonçalves, Roberto Calderon

Ciência Animal Brasileira

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2021, Volume 22 elocation e-67849

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo A urolitíase obstrutiva é frequente na ovinocultura e possui etiologia multifatorial, porém o manejo nutricional inadequado é considerado o mais relevante para sua ocorrência. Os objetivos deste estudo foram verificar a influência de duas dietas com diferentes proporções e concentrações de cálcio (Ca) e fósforo (P) no desenvolvimento da urolitíase obstrutiva, e descrever os achados clínicos e anatomopatológicos do sistema urinário de ovinos. Utilizaram-se 30 cordeiros, machos, mestiços das raças Santa Inês e Ile de France, que foram aleatoriamente distribuídos em dois grupos: Grupo 1 (G1, n=15) - Ca:P de 1,9:1 e 0,42% de P; Grupo 2 (G2, n=15) - Ca:P de 1,5:1 e 0,65% de P. As dietas foram fornecidas por 90 dias consecutivos com feno de Coast-cross, farelo de soja, trigo e milho, e água ad libitum. Após o diagnóstico da doença, os cordeiros foram submetidos ao tratamento clínico e cirúrgico, quando necessário. A urolitíase foi detectada em 36,7% (11/30) dos cordeiros, sendo 26,7% assintomáticos e 10% (3/30) apresentaram obstrução uretral. Um cordeiro foi desobstruído após amputação do processo uretral e sondagem uretral; outro foi a óbito por ruptura vesical e uroperitôneo; outro foi sacrificado após uretrostomia perineal e cistostomia sem sucesso. Em ambos os grupos, as alterações histopatológicas renais mais frequentes foram congestão vascular, dilatação e degeneração tubular. A presença de proteínas na luz tubular foi mais pronunciada no G2. As dietas fornecidas, ricas em concentrado, embora com relação Ca:P adequadas, provocaram a calculogênese, o que comprovou que o excesso de minerais e pouca quantidade de volumoso podem causar a enfermidade no rebanho.

Abstract Obstructive urolithiasis is common in farmed sheep and has a multifactorial etiology, but inadequate nutritional management is considered the most relevant condition for its occurrence. The objectives of this study were to verify the influence of two diets with different concentrations of calcium (Ca) and phosphorus (P) on the development of obstructive urolithiasis, and to describe the clinical and anatomopathological findings of the urinary system in sheep. Thirty male crossbred Santa Inês and Ile de France lambs were randomly distributed into two groups: Group 1 (G1, n = 15) - Ca: 1.9:1 P and 0.42% P; Group 2 (G2, n = 15) - Ca: P 1.5:1 and 0.65% P. The diets consisting of Coast-cross hay, soybean meal, wheat, and corn were provided for 90 consecutive days with water ad libitum. After the diagnosis of the disease, the lambs were subjected to clinical and surgical treatment, when necessary. Urolithiasis was detected in 36.7% (11/30) of lambs, 26.7% were asymptomatic and 10% (3/30) had urethral obstruction. A lamb was unobstructed after amputation of the urethral process and urethral catheterization, one died of bladder and uroperitoneum rupture, and another was sacrificed after the failure of perineal urethrostomy and cystostomy. The most frequent renal histopathological changes were vascular congestion, dilation, and tubular degeneration. Proteins in the tubular lumen were more pronounced in G2. The diets were rich in concentrate and had adequate Ca:P ratios, but caused calculogenesis, showing that excess minerals and a small amount of roughage can cause disease in the herd.

https://doi.org/10.1590/1809-6891v22e-67849 312 downloads

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E. Brentani, Alexandra V. M. Neto, Álvaro José S. Ihara, Amanda Santos, Andrea R. Canton, Ana Pinheiro M. Watanabe, Andreia Santos, Angélica C. dos Pastorino, Antonio C. Franco, Bernadette D. G. M. Caruzo, Bruna Ceneviva, Carina Martins, Carolina C. M. F. Prado, Danilo Abellan, Deipara M. Benatti, Fabiana B. Smaria, Fabiana Gonçalves, Fernanda T. Penteado, Fernando D. Castro, Gabriela S. F. de Gonçalves, Guilherme S. Roschel, Hamilton Disi, Ilana R. Marques, Isabela G. Castro, Inar A. Buscatti, Izabel M. Faiad, Jaline Z. Fiamoncini, Jarlei Rodrigues, Joaquim C. Carneiro, Jorge D. A. Paz, Jose A. Ferreira, Juliana C. Ferreira, Juliana C. O. Silva, Katia R. Bastos, Karina L. M. Kozu, Katia Cristofani, Lilian M. Souza, Lucas V. B. Campos, Lucia M. A. Silva Filho, Luiz Vicente R. F. Sapienza, Marcelo T. Lima, Marcos S. Garanito, Marlene P. Santos, Márcia F. A. Dorna, Mayra B. Aikawa, Nadia E. Litvinov, Nadia Sakita, Neusa K. Gaiolla, Paula V. V. Pasqualucci, Paula Toma, Ricardo K. Correa-Silva, Simone Sieczkowska, Sofia M. Imamura, Marta Forsait, Silvana Santos, Vera A. Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3511

Resumo: En | Texto: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

10.

In vitro morphogenesis of Physalis ixocarpa Brot ex. Horm
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Alvarado, Domitzel Zagal

; Lima, Andressa Priscila Piancó Santos

; Santana, José Raniere Ferreira de

; Lima-Brito, Alone

Pesquisa Agropecuária Tropical

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2021, Volume 51 elocation e69416

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Physalis ixocarpa Brot. ex Horm. é considerada a espécie economicamente mais importante do gênero. A cultura de tecidos é apontada como uma estratégia para a sua propagação; no entanto, pesquisas indicam que as respostas in vitro são genótipo-dependentes. Objetivou-se avaliar a morfogênese in vitro das variedades verde e roxa de P. ixocarpa, tendo-se em vista a propagação massiva da espécie. A capacidade morfogênica dos explantes nó cotiledonar, hipocótilo e cotilédone foi avaliada em meio Murashige & Skoog suplementado com benzilaminopurina - BAP (0,00; 2,5; 5,0; 7,5; ou 10,0 µM) e ácido naftalenoacético - ANA (0,00 ou 2,5 μM), utilizando-se delineamento experimental inteiramente casualizado, em esquema fatorial 3 x 5 x 2, sendo 30 tratamentos para cada variedade. Foram analisados o número de brotos por organogênese direta e indireta e a porcentagem de explantes com calo. A expressão morfogenética in vitro de P. ixocarpa é influenciada pelo tipo de explante e pelos reguladores vegetais BAP e ANA. O explante nó cotiledonar é eficiente para a produção de brotos via organogênese direta nas duas variedades estudadas.

ABSTRACT Physalis ixocarpa Brot. ex Horm. is considered the most economically important species of the genus. Tissue culture is pointed out as a strategy for its propagation, but researches indicate that in vitro responses are genotype-dependent. This study aimed to evaluate the in vitro morphogenesis of the P. ixocarpa green and purple varieties, in view of the massive propagation of the species. The morphogenic capacity of the explants cotyledonary node, hypocotyl and cotyledon was evaluated in Murashige & Skoog medium supplemented with benzylaminopurine - BAP (0.00, 2.5, 5.0, 7.5 or 10.0 μM) and naphthaleneacetic acid - NAA (0.00 or 2.5 μM), using a completely randomized experimental design, in a 3 x 5 x 2 factorial scheme, with 30 treatments for each variety. The number of shoots per direct and indirect organogenesis and the percentage of explants with callus were analyzed. The in vitro morphogenetic expression of P. ixocarpa is influenced by the type of explant and by the plant regulators BAP and NAA. The cotyledonary node explant is efficient for the production of shoots via direct organogenesis in the two varieties studied.

https://doi.org/10.1590/1983-40632021v5169416

11.

Expeditious Syntheses to Pharmochemicals 1,3-Dihydroxyacetone, 1,3-Dichloro-, 1,3-Dibromo- and 1,3-Diiodoacetone from Glycerol 1,3-Dichlorohydrin Using Homogenous and Heterogenous Medium
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Silva, Fernanda Priscila N. R. da

; Santos, Priscila F. dos Silva, Sara R. B. da Pereira, Vera Lúcia P.

Journal of the Brazilian Chemical Society

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Ago 2020, Volume 31 Nº 8 Páginas 1725 - 1731

Resumo: En | Texto: En | PDF: En

New efficient and reproductive routes to production of 1,3-dihydroxyacetone (1), 1,3-dichloroacetone (6), 1,3-dibromoacetone (7) and 1,3-diiodoacetone (8) from glycerol 1,3-dichlorohydrin (3) were developed. The synthesis of 1 was processed in three steps from glycerol 2 (1,3-selective chlorination of 2 to 3, oxidation of 3 to 6 and subsequent di-hydroxylation) in 51% overall yield. On the other hand, 7 and 8 were produced from3, via a trans-bromination and trans-iodination, respectively, followed by oxidation and hydroxylation steps, in 38-52% overall yield. It was used homogeneous media with different reagents (HCl/AcOH, pyridinium chlorochromate (PCC), PCC-HIO4) and heterogeneous media with reagents supported on polymer resins such as Amberlyst® A26-HCrO4– form, PV-PCC (polyvinyl-pyridinium chlorochromate) and Amberlyst® A26-OH- form or reagents supported on alumina such as KI/Al2O3, KBr/Al2O3, in solvent free conditions.

https://doi.org/10.21577/0103-5053.20200058 537 downloads

12.

Hystometric evaluation of nickel chronic exposure effects on large instestine of adult Wistar male rats
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Assis Rodrigues, Maria Luiza Rodrigues Sartori, Sirlene Souza Santos Totaro, Priscila Izabel Pinto da Matta, Sérgio Luis

Revista de Ciencias Agrícolas

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Dez 2019, Volume 36 Nº spe Páginas 21 - 30

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La ingestión de cantidades considerables de agua o alimentos contaminados con níquel puede ser muy tóxica. El presente trabajo se realizó con el objetivo de evaluar los efectos de las exposiciones al níquel en el colon ascendente de ratas macho Wistar adultas a nivel histométrico. Utilizamos 12 animales que se dividieron en un control (agua ingerida no contaminada) y un grupo contaminado con níquel (es decir, 25 mg de níquel / L de agua). Se ofreció cloruro de níquel en agua desclorinada y el experimento tuvo un período de exposición de 56 días. Una parte del colon ascendente se retiró de los animales y se sometió a procesos de marcaje histológico usando toluidina azul (para descripción histométrica general), azul de Alcian (AB, para mucinas ácidas) y la técnica periódica de ácido-Schiff (PAS) (para mucinas neutras). Las diferencias potenciales entre los grupos se diseñaron mediante la aplicación de la prueba de Whitney y la prueba t (p <0.05). Las criptas eran más pequeñas para el grupo contaminado con níquel, a pesar de que estos organismos exhibían criptas más amplias y más altas. Los animales contaminados con níquel exhibieron una menor cantidad de células caliceiformes con reacciones positivas AB y PAS, así como una menor cantidad de moco en comparación con los animales no contaminados con níquel. Dichas reducciones en la cantidad de células caliceiformes con reacciones positivas AB y PAS pueden estar relacionadas con las criptas menos profundas, lo que posiblemente redujo la síntesis y secreción de mucinas, comprometiendo los aspectos funcionales (p. Ej., lubricación y protección de la mucosa intestinal) del intestino grueso contaminado con níquel. Curiosamente, las criptas más anchas y más altas y la columna de epitelio más alta en los animales contaminados con níquel pueden representar una compensación relevante para la protección de la mucosa intestinal.

ABSTRACT The ingestion of considerable amounts of water or food contaminated with nickel can be very toxic. The present work was conducted aiming to evaluate the effects of nickel exposures on ascending colon of adult Wistar male rats at hystometric level. We used 12 animals that were divided in a control (ingested uncontaminated water) and a nickel-contaminated (i.e., 25 mg de nickel/L of water) groups. Nickel chloride was offered in declorinated water and the experiment had a 56 days exposure period. A portion of the ascending colon was removed of the animals and subjected to hystological labelling processes using blue toluidin (for general hystometric description), Alcian Blue (AB, for acid mucins) and periodic acid-Schiff (PAS) technique (for neutral mucins). The potential differences between groups were desgined by applying the Whitney test and t test (p < 0.05). The crypts were smaller for the nickel-contaminated group, even though these organism exhibited broader and higher crypts. Nickel-contaminated animals exhibited a smaller amount of calyceform cells with AB and PAS positive reactions as well as a less mucus quantities when compared with nickel-uncontaminated animals. Such reductions on the amount of calyceform cells with AB and PAS positive reactions may be related wiht the shallower crypts, which possibly reduced the synthesis and secretion of mucins, compromissing the functional aspects (e.g., lubrification and intestinal mucosa protection) of the nickel-contaminated large intestines. Interestingly, the wider and higher crypts and higher epithelium collumn on the nickel-contaminated animals may represent a relevant trade-off for the intestinal mucosa protection.

https://doi.org/10.22267/rcia.1936e.103

13.

Fatores moleculares associados com a patogenicidade de Phytophthora cinnamomi
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Lourenço, Darling de Andrade Leon, Priscila Marques Moura de Santos, Luís Choupina, Altino Branco

Revista de Ciências Agrárias

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Dez 2019, Volume 42 Nº 4 Páginas 211 - 220

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Phytophthora cinnamomié um patógeno do solo que possui uma ampla gama de hospedeiros em diversos países de diferentes climas. Esse fungo é responsável pela doença da tinta do castanheiro europeu (Castanea sativaMiller) e conduz à morte da árvore. Portugal se destaca na produção do castanheiro europeu. Entretanto, entre 2002 e 2004, houve uma redução de 27.3% na área de distribuição dessa área devido ao P. cinnamomi. O objetivo deste trabalho foi identificar fatores moleculares possivelmente associados à patogenicidade do fungo através de sequências genômicas depositadas no NCBI utilizando ferramentas de bioinformática. O primeiro contig foi utilizado e as ORFs presentes nas sequências foram identificadas. Foi utilizado o smartBlast em busca de proteínas homólogas. A predição da localização celular das proteínas foi feita através de quatro ferramentas: SignalP 4.1, Cello v.2.5, LOCTree3, Euk-mPLoc 2.0. A caracterização dos domínios dos produtos foi realizada utilizando o PROSITE e a predição das estruturas foi realizada utilizando o servidor Phyre2. Foram encontradas 13 proteínas provavelmente associadas com a patogenicidade de P. cinnamomie as suas propriedades relacionadas com a infecção foram analisadas in silico.Esses resultados são importantes uma vez que são uma primeira etapa na busca por fatores patogênicos.

Phytophthora cinnamomiis soil pathogen that has a wide range of hosts in several countries and different climates. This fungus is responsible for the chestnut ink disease (Castanea sativaMiller) and death of the tree. Portugal stands out in the production of the European chestnut tree. However, between 2002 and 2004, there was a decrease of 27.3% in the distribution area of this tree due to P. cinnamomi. The aim of this study was to identify molecular factors possibly associated with the fungal pathogenicity through genomic sequences deposited at NCBI using bioinformatics tools. The first contig was used and the OFRs present in de sequences were identified. SmartBlast was used for homologous proteins. The prediction of cellular localization prediction of proteins was performed using four different tools: SignalP 4.1, Cello v.2.5, LOCTree3, Euk-mPLoc 2.0. Protein domains characterization was accomplished using PROSITE and the structure prediction was performed using Phyre2 server. We found 13 proteins probably associated with the pathogenicity of P. cinnamomi and its properties related to the infection were analyzed in silico.These results are important since they are a first step in the search for pathogenic factors.

https://doi.org/10.19084/rca.18577

14.

A newly validated HPLC–DAD-UV method to study the effects of medicinal plants extracts, fractions and isolate compounds on gastric emptying in rodents
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Siqueira, Monica R.P.

; Rosa, Lorenna C. da

; Santos, Rafael de O.

; Lopes, Marina Priscila G. da S.

; Paumgartten, Francisco J.R.

; Moreira, Davyson de Lima

Revista Brasileira de Farmacognosia

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Out 2019, Volume 29 Nº 5 Páginas 597 - 604

Resumo: En | Texto: En | PDF: En

Abstract In this study, we developed and validated a chromatographic method by High-performance Liquid Chromatography coupled to Diode-Array Ultraviolet Detector for quantification of acetaminophen in small volumes of plasma. This analytical method is particularly suitable for studies of gastric emptying time and pharmacokinetics in small rodents. Orally administered acetaminophen is promptly and completely absorbed in the intestines, with negligible absorption from the stomach. Owing to these kinetic features, acetaminophen can be used to study gastric emptying. The newly-validated analytical method was employed to investigate whether plants used as anti-dyspeptics in the Brazilian traditional medicine affect the gastric emptying. Lyophilized aqueous extracts from leaves of Baccharis trimera (Less) DC., Asteraceae (carqueja), Maytenus ilicifolia Mart. Ex Reissek, Celastraceae (espinheira-santa) and Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Verbenaceae (erva-cidreira) were administered by gavage to female Wistar rats 30 min before a single oral dose of acetaminophen (50 mg/kg). L. alba extract (50 mg/kg) did not alter acetaminophen plasma concentration versus time curve an indication that it has no effect on gastric emptying. Extracts of B. trimera (50 mg/kg) and M. ilicifolia (30 and 50 mg/kg, but not 10 mg/kg), however, slightly delayed gastric emptying. M. ilicifolia given by intraperitoneal route (30 mg/kg) also retarded gastric emptying. In conclusion, the newly-validated analytical method is adequate for studying the effects of medicinal plants on gastric emptying.

https://doi.org/10.1016/j.bjp.2019.03.003 665 downloads

15.

THERMODYNAMIC ANALYSIS AND MODELING OF BRAZILIAN CRUDE OIL AND ASPHALTENE SYSTEMS: AN EXPERIMENTAL MEASUREMENT AND A PC-SAFT APPLICATION
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Neuhaus, Natalia

; Nascimento, Priscila T. H.

; Moreira, Isabele

; Scheer, Agnes P. Santos, Alexandre F. Corazza, Marcos L.

Brazilian Journal of Chemical Engineering

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Mar 2019, Volume 36 Nº 1 Páginas 557 - 571

Resumo: En | Texto: En | PDF: En

ABSTRACT Asphaltenes represent the heaviest fraction of crude oils, being recognized by their tendency to self-associate and precipitate. Asphaltene precipitation and subsequent deposition can cause problems in all stages of production. The objective of this paper is to model Brazilian crude oil and asphaltene systems using the PC-SAFT equation of state. Asphaltenes were extracted from crude oil through the addition of different n-alkanes. The PC-SAFT was capable of accurately predicting liquid density for toluene and asphaltenes and boiling point elevation for crude oil at different concentrations of toluene. Asphaltene precipitation from model oil allowed us to evaluate the influence of binary interaction parameters on modeling results. The influence of precipitant agent (n-hexane and n-heptane) on the asphaltene phase behavior was analyzed, showing that n-hexane was able to precipitate more asphaltenes than n-heptane, as expected. Furthermore, simulated results are in agreement with experimental observations: the average relative errors are 3.75 % and 10.25 % for the weight percentage of precipitated asphaltene using n-hexane and n-heptane as precipitant, respectively.

https://doi.org/10.1590/0104-6632.20190361s20170575 1241 downloads

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