Resumo Objetivou-se refletir sobre o impacto do racismo estrutural na saúde dos adolescentes afrodescendentes brasileiros, considerando o contexto político e social do período pós-abolição, quando foi iniciada uma nova configuração de exploração e manutenção das desigualdades sociais relacionadas aos escravizados libertos e seus descendentes. É na adolescência, fase da vida ligada ao contexto social e cultural, e não apenas determinada pelo período cronológico da vida, quando geralmente o indivíduo negro começa a vivenciar de modo mais consciente o estigma da raça. Este ensaio, inicialmente, apresenta o percurso histórico da construção social da raça nos padrões de dominação e o racismo. Em seguida, reflete, balizado no racismo estrutural, sobre o papel do capitalismo monopolista no desenvolvimento e crescimento econômico do Brasil pós-abolicionista, como um dos principais mecanismos de recrutamento e manutenção da população negra nas classes sociais inferiores e marginalizadas. Por fim, discute como o racismo impacta a saúde dos adolescentes afrodescendentes brasileiros a partir da teoria ecossocial, proposta por Nancy Krieger, e de bibliografia representativa. O racismo estrutural em nossa sociedade impacta na saúde dos adolescentes negros, com forte determinação no processo de saúde-doença. Por isso, é preciso combater as disparidades históricas, no sentido de se construir uma sociedade mais democrática e igualitária. Objetivouse Objetivou pósabolição, pósabolição pós abolição, abolição pós-abolição descendentes adolescência cultural ensaio inicialmente seguida reflete pósabolicionista, pósabolicionista abolicionista, abolicionista pós-abolicionista marginalizadas fim ecossocial Krieger representativa negros saúdedoença. saúdedoença doença. doença saúde-doença isso históricas igualitária

Abstract The objective was to reflect on the impact of structural racism on the health of Brazilian Afro-descendant adolescents, considering the political and social context of the post-abolition period, when a new configuration of exploitation and maintenance of social inequalities related to freed slaves and their descendants began. It is during adolescence, a phase of life linked to the social and cultural context, and not just determined by the chronological period of life, when black individuals generally begin to experience the stigma of race more consciously. This essay initially presents the historical path of the social construction of race in patterns of domination and racism. It then reflects, based on structural racism, on the role of monopoly capitalism in the development and economic growth of post-abolitionist Brazil, as one of the main mechanisms for recruiting and maintaining the black population in lower and marginalized social classes. Finally, it discusses how racism impacts the health of Brazilian Afro-descendant adolescents based on the ecosocial theory, proposed by Nancy Krieger, and representative bibliography. Structural racism in our society impacts the health of black adolescents, with a strong determination in the health-disease process; Therefore, it is necessary to combat historical disparities, to build a more democratic and egalitarian society. Afrodescendant Afro descendant postabolition post abolition began adolescence consciously reflects postabolitionist abolitionist Brazil classes Finally theory Krieger bibliography healthdisease disease process Therefore disparities

ABSTRACT Sporotrichosis is a neglected mycosis that affects human and animal hosts, including domestic cats. In Brazil, its most frequently diagnosed etiological agent is Sporothrix brasiliensis. Zoonotic transmission of S. brasiliensis occurs via direct contact between an infected cat and a susceptible human host. Notification of confirmed cases of feline sporotrichosis is not mandatory in Brazil. The metropolitan area of Goiania city can be considered a silent area for the occurrence of feline sporotrichosis. In this context, voluntary reporting of feline sporotrichosis cases is recommended for all healthcare professionals. This study aimed to report the first occurrence of S. brasiliensis in a cat from the metropolitan area of Goiania city. Cytopathology, mycology, thermal dimorphism and calmodulin gene amplification tests were performed. The mycological and molecular biological diagnoses corresponded to S. brasiliensis. The etiological agent of zoonotic sporotrichosis was detected in the metropolitan area of Goiania city, and therefore there is a risk of the emergence of new cases of cats infected with S. brasiliensis and the occurrence of zoonotic transmission of this fungus. hosts Brazil S host context professionals Cytopathology mycology performed fungus

Resumen: Este estudio pretende identificar la percepción de los estudiantes del sector salud sobre las dificultades académicas y no académicas, las estrategias de coping y la presencia de estrés. Este estudio transversal, con enfoque cuantitativo y cualitativo, utilizó cuestionarios estructurados e inventarios psicométricos validados (escala Brief COPE; inventario de sintomatología de estrés ISE ); además de entrevistas para ampliar la comprensión de los resultados de los instrumentos cuantitativos. En la etapa cuantitativa participaron 162 estudiantes de los cursos de grado en Fisioterapia, Fonoaudiología, Medicina, Nutrición y Terapia Ocupacional. De estos, 60 participaron en la entrevista cualitativa. Los resultados se sometieron a análisis estadístico univaria nte, para distinguir los grupos y asociaciones entre variables, y a análisis multivariado por regresión logística para identificar variables independientes que determinan el estrés. Los estudiantes reportaron enfrentar muchas dificultades académicas y no académicas, y utilizaban diferentes estrategias de coping. El análisis estadístico univariante no obtuvo diferencias significativas entre cursos y etapas respecto al número de dificultades y estrategias utilizadas. Un 45% y 100% de los estudiantes experimentaron estrés según el curso y la etapa considerada, sin diferencias significativas entre ellos. Se encontraron cinco variables independientes como factores de estrés: sexo femenino, renta familiar, número de dificultades académicas/no académicas y número de estrategias de coping orientadas a la “emoción”. El estrés patológico estuvo relacionado solo a la variable número de dificultades no académicas. Se necesita mantener acciones institucionales de asistencia social y apoyo psicológico para favorecer una planificación efectiva de medidas de promoción de salud mental de los estudiantes. Resumen transversal cualitativo escala COPE ) cuantitativos 16 Fisioterapia Fonoaudiología Medicina Ocupacional estos 6 cualitativa nte utilizadas 45 100 considerada ellos femenino familiar académicasno emoción. emoción . “emoción” 1 4 10 “emoción

Abstract: This study aimed to find undergraduate students’ perceptions about academic and non-academic difficulties and coping strategies and determining the occurrence of stress among them. This was a cross-sectional study using quantitative and qualitative approaches to evaluate students from different health professions in a single institution. Physical therapy, speech therapy, medicine, nutrition, and occupational therapy program students (N=162) answered a structured questionnaire and two validated psychometric inventories (COPE Brief scale and the ISS stress symptoms inventory). Additionally, 60 students underwent a semi-structured interview to better understand the results from the quantitative instruments. Quantitative data underwent univariate analysis to test differences between proportions and stepwise multiple regression analysis to identify the independent determinants of stress. Students reported a large number of academic and non-academic difficulties and a variety of coping strategies. Univariate statistical analysis showed no significant differences between courses and stages regarding the number of difficulties and coping strategies. A large proportion of students showed stress, ranging from 45% to 100%, depending on the course and stage, with no significant differences between them. Multivariate statistical analysis found five independent variables as stress determinants: female gender, low family income, number of academic and non-academic difficulties, and number of emotion-focused coping strategies. This analysis also showed that pathological stress is related to only one variable: the number of non-academic difficulties. These findings reinforce the importance of maintaining institutional actions for student social assistance and psychological support. Results also provide meaningful data for adequately planning more effective measures to promote students’ mental health. Abstract nonacademic non them crosssectional cross sectional institution medicine nutrition N=162 N162 N 162 (N=162 COPE inventory. inventory . inventory) Additionally 6 semistructured semi instruments 45 100 100% stage gender income emotionfocused emotion focused variable support N=16 N16 16 (N=16 4 10 N=1 N1 1 (N=1 N= (N= (N

Resumo: Este estudo pretende identificar a percepção de estudantes de uma mesma instituição de ensino superior da área da saúde sobre dificuldades acadêmicas e não acadêmicas, estratégias de coping e identificar a presença de estresse. Foi um estudo transversal utilizando abordagens quantitativa e qualitativa, desenvolvido por meio de questionário estruturado e inventários psicométricos validados ( COPE Breve; inventário de sintomas de estresse ISLL ). Adicionalmente, foram realizadas entrevistas para ampliar a compreensão dos resultados dos instrumentos quantitativos. Na etapa quantitativa, participaram 162 estudantes dos cursos de graduação em Fisioterapia, Fonoaudiologia, Medicina, Nutrição e Terapia Ocupacional. Destes, 60 participaram de entrevista qualitativa. Os dados foram submetidos à análise estatística univariada e análise multivariada por regressão logística. Os estudantes relataram encontrar grande número de dificuldades e utilizar variadas estratégias de coping . A análise estatística univariada demonstrou que não houve diferenças importantes entre cursos e etapas quanto ao número de dificuldades e estratégias utilizadas. A presença de estresse foi identificada em proporções entre 45% e 100% dos estudantes, conforme o curso e a etapa considerada, sem diferenças significativas entre eles. A análise multivariada identificou cinco variáveis independentes como determinantes de estresse: sexo feminino, renda familiar, número de dificuldades acadêmicas/não acadêmicas e número de estratégias de coping voltadas à “emoção” presentes. Esta análise também mostrou que o estresse patológico está relacionado a somente uma variável: o número de dificuldades não acadêmicas. Estes achados reforçam a necessidade de manter ações institucionais de assistência social e apoio psicológico, favorecendo assim um planejamento efetivo de medidas de promoção da saúde mental dos estudantes. Resumo qualitativa Breve ) Adicionalmente quantitativos 16 Fisioterapia Fonoaudiologia Medicina Ocupacional Destes 6 logística utilizadas 45 100 considerada eles feminino familiar acadêmicasnão emoção “emoção presentes variável psicológico 1 4 10

Abstract Specific products containing natural resources can contribute to the innovation of complete denture hygiene. Objective: To conduct an in vitro evaluation of experimental dentifrices containing essential oils of Bowdichia virgilioides Kunth (BvK), Copaifera officinalis (Co), Eucalyptus citriodora (Ec), Melaleuca alternifolia (Ma) and Pinus strobus (Ps) at 1%. Methodology: The variables evaluated were organoleptic and physicochemical characteristics, abrasiveness (mechanical brushing machine) simulating 2.5 years, and microbial load (Colony Forming Units - CFU/mL), metabolic activity (XTT assay) and cell viability (Live/Dead® BacLight™ kit) of the multispecies biofilm (Streptococcus mutans: Sm, Staphylococcus aureus: Sa, Candida albicans: Ca and Candida glabrata: Cg). Specimens of heat-polymerized acrylic resins (n=256) (n=96 specimens for abrasiveness, n=72 for microbial load count, n=72 for biofilm metabolic activity, n=16 for cell viability and total biofilm quantification) with formed biofilm were divided into eight groups for manual brushing (20 seconds) with a dental brush and distilled water (NC: negative control), Trihydral (PC: positive control), placebo (Pl), BvK, Co, Ec, Ma or Ps. After brushing, the specimens were washed with PBS and immersed in Letheen Broth medium, and the suspension was sown in solid specific medium. The organoleptic characteristics were presented by descriptive analysis. The values of density, pH, consistency and viscosity were presented in a table. The data were analyzed with the Wald test in a generalized linear model, followed by the Kruskal-Wallis test, Dunn's test (mass change) and the Bonferroni test (UFC and XTT). The Wald test in Generalized Estimating Equations and the Bonferroni test were used to analyze cell viability. Results: All dentifrices showed stable organoleptic characteristics and adequate physicochemical properties. CN, Ec, Ps, Pl and PC showed low abrasiveness. There was a significant difference between the groups (p<0.001) for microbial load, metabolic activity and biofilm viability. Conclusions: It was concluded that the BvK, Ec and Ps dentifrices are useful for cleaning complete dentures, as they have antimicrobial activity against biofilm. The dentifrices containing Bowdichia virgilioides Kunth showed medium abrasiveness and should be used with caution. hygiene Objective BvK , (BvK) Co (Co) (Ec) (Ma (Ps 1 1% Methodology mechanical machine 25 2 5 2. years Colony CFU/mL, CFUmL CFU/mL CFU mL CFU/mL) XTT assay Live/Dead® LiveDead Live Dead (Live/Dead BacLight kit Streptococcus mutans Sm aureus Sa albicans glabrata Cg. Cg . Cg) heatpolymerized heat polymerized n=256 n256 n 256 (n=256 n=96 n96 96 (n=9 n72 72 n=7 count n16 16 n=1 quantification 20 (2 seconds NC (NC control, control control) (PC Pl, (Pl) analysis density pH table model KruskalWallis Kruskal Wallis Dunns Dunn s mass change UFC XTT. XTT) Results properties CN p<0.001 p0001 p 0 001 (p<0.001 Conclusions dentures caution (BvK (Co (Ec Live/Dead n=25 n25 (n=25 n=9 n9 9 (n= n7 7 n= n1 ( (Pl p<0.00 p000 00 (p<0.00 n=2 n2 (n=2 (n p<0.0 p00 (p<0.0 p<0. p0 (p<0. p<0 (p<0 p< (p< (p

Aim This study aimed to investigate the occurrence of enamelin gene (ENAM) single nucleotide polymorphisms (SNP) and ENAM polymorphism association with dental anomalies (DA) in individuals with unilateral or bilateral cleft lip and palate (CLP). Methods Saliva samples were collected from 147 individuals aged between 6 and 15 years-old, both genders, and divided into 4 groups: Group 1 (G1) - CLP and DA; Group 2 (G2) - CLP without DA; Group 3 (G3) - without CLP with DA; Group 4 (G4) - without CLP and DA. The genomic DNA was extracted from saliva samples and the following ENAM SNPs markers were genotyped: rs3796703, rs3796704, rs3796705, rs7671281, rs2609428, and rs35951442. Fisher exact and Pearson’s Chi-square tests statistically analyzed the results (α=5%). Results Individuals without CLP with DA (Group 3 - 19.2%) showed statistically higher prevalence of SNP rs2609428 heterozygotes (p=0.006) than individuals with CLP and DA (Group 1 - 0%). Individuals without CLP (10%) exhibited statistically higher prevalence of mutated heterozygotes/homozygous (p=0.028) than in individuals with CLP (1.3%). Conclusion SNP rs2609428 marker of ENAM gene may be associated with dental anomalies in individuals without cleft lip and palate. (ENAM (SNP (DA CLP. . (CLP) 14 yearsold, yearsold years old, old years-old genders groups G1 G (G1 G2 (G2 G3 (G3 G4 (G4 genotyped rs3796703 rs rs3796704 rs3796705 rs7671281 rs35951442 Pearsons Pearson s Chisquare Chi square α=5%. α5 α α=5% 5 (α=5%) 19.2% 192 19 rs260942 p=0.006 p0006 p 0 006 (p=0.006 0%. 0% 0%) 10% 10 (10% heterozygoteshomozygous homozygous p=0.028 p0028 028 (p=0.028 1.3%. 13 1.3% (1.3%) (CLP (G rs379670 rs767128 rs3595144 α=5 (α=5% 19.2 rs26094 p=0.00 p000 00 (p=0.00 (10 p=0.02 p002 02 (p=0.02 1.3 (1.3% rs37967 rs76712 rs359514 α= (α=5 19. rs2609 p=0.0 p00 (p=0.0 (1 1. (1.3 rs3796 rs7671 rs35951 (α= rs260 p=0. p0 (p=0. ( (1. rs379 rs767 rs3595 (α rs26 p=0 (p=0 rs37 rs76 rs359 rs2 p= (p= rs3 rs7 rs35 (p

Abstract This research assessed the efficiency of chemically modified tannins as coagulants for water treatment. Tannins from Anacardium occidentale (cashew tree) and Mimosa caesalpiniifolia (‘sabiá’) barks and seedless fruits of Anadenanthera colubrina (‘angico’) and Pityrocarpa moniliformis (‘angico de bezerro’) were evaluated after cationization to remove turbidity from water. After extraction, the total solids content (TSC), Stiasny index (SI), and total condensed tannins content (TCC) of the tannins extracts were determined. Extracted tannins were converted into powders and cationized. Then, the cationized tannins' effectiveness on water turbidity removal, sedimentation time, and effect on pH were assessed. Three concentrations of each type of tannin were used to evaluate flocculant efficiency: 50, 100, and 150 mg L-1. Although the P. moniliformis extract had a higher TSC value (56.06%), it presented the lowest SI (0.42%) and TTC (0.23%) values. M. caesalpiniifolia had the lowest TSC (9.18%) and the highest SI (91.27%), while Ac occidentale stood out with the highest TCC (19.83%). All species have shown potential for tannin production and efficiently removed turbidity at all concentrations. However, only A. occidentale, at a concentration of 100 mg L-1, presented a nephelometric turbidity unit of 2.4, reaching the potability standards required by international specifications and, therefore, being indicated for water treatment. treatment cashew tree ‘sabiá sabiá (‘sabiá’ ‘angico angico (‘angico’ bezerro bezerro’ extraction TSC, , (TSC) SI, (SI) (TCC determined Then removal time 50 15 L1. L1 L 1. 1 L-1 P 56.06%, 5606 56.06% 56 06 (56.06%) 0.42% 042 0 42 (0.42% 0.23% 023 23 (0.23% values M 9.18% 918 9 18 (9.18% 91.27%, 9127 91.27% 91 27 (91.27%) 19.83%. 1983 19.83% . 19 83 (19.83%) However A 10 L1, 1, 24 2 4 2.4 therefore (‘sabiá (TSC (SI 5 L- 560 56.06 (56.06% 0.42 04 (0.42 0.23 02 (0.23 9.18 (9.18 912 91.27 (91.27% 198 19.83 8 (19.83% 2. 56.0 (56.06 0.4 (0.4 0.2 (0.2 9.1 (9.1 91.2 (91.27 19.8 (19.83 56. (56.0 0. (0. 9. (9. 91. (91.2 19. (19.8 (56. (0 (9 (91. (19. (56 ( (91 (19 (5 (1

Resumo O presente trabalho teve como objetivo avaliar a eficiência de taninos quimicamente modificados como coagulantes para tratamento de água. Os taninos das cascas de Anacardium occidentale (cajueiro) e Mimosa caesalpiniifolia (sabiá) e dos frutos sem sementes de Anadenanthera colubrina (angico) e Pityrocarpa moniliformis (angico de bezerro) foram avaliados após cationização para remover a turbidez da água. Após a extração, os extratos de taninos tiveram o teor de sólidos totais (TST), o índice de Stiasny (IS) e o teor de taninos totais condensados (TCT). Os taninos extraídos foram convertidos em pó e cationizados. Em seguida, avaliou-se a eficácia dos taninos cationizados na remoção da turbidez e o tempo de sedimentação além do efeito no pH da água. Para avaliar a eficiência dos taninos cationizados como floculantes foram utilizadas três concentrações de cada tipo de material: 50, 100 e 150 mg L-1. Embora o extrato de P. moniliformis tenha apresentado maior valor de TST (56,06%), apresentou os menores valores de IS (0,42%) e TCT (0,23%). Os taninos da casca de M. caesalpiniifolia apresentou o menor TST (9,18%) e o maior IS (91,27%), enquanto os derivados de A. occidentale se destacaram pelo maior TCT (19,83%). Todas as espécies demonstraram potencial para produção de taninos e foram eficientes em remover a turbidez da água em todas as concentrações. Porém, apenas o A. occidentale, na concentração de 100 mg L-1, apresentou unidade de turbidez nefelométrica de 2,4, atingindo os padrões de potabilidade exigidos pelas especificações internacionais e, portanto, sendo indicado para tratamento de água. cajueiro (cajueiro sabiá (sabiá angico bezerro extração TST, , (TST) (IS TCT. . (TCT) seguida avaliouse avaliou material 50 10 15 L1. L1 L 1. 1 L-1 P 56,06%, 5606 56,06% 56 06 (56,06%) 0,42% 042 0 42 (0,42% 0,23%. 023 0,23% 23 (0,23%) M 9,18% 918 9 18 (9,18% 91,27%, 9127 91,27% 91 27 (91,27%) A 19,83%. 1983 19,83% 19 83 (19,83%) Porém L1, 1, 24 2 4 2,4 portanto (TST (TCT 5 L- 560 56,06 (56,06% 0,42 04 (0,42 02 0,23 (0,23% 9,18 (9,18 912 91,27 (91,27% 198 19,83 8 (19,83% 2, 56,0 (56,06 0,4 (0,4 0,2 (0,23 9,1 (9,1 91,2 (91,27 19,8 (19,83 56, (56,0 0, (0, (0,2 9, (9, 91, (91,2 19, (19,8 (56, (0 (9 (91, (19, (56 ( (91 (19 (5 (1

Abstract The objective was to reflect on the impact of structural racism on the health of Brazilian Afro-descendant adolescents, considering the political and social context of the post-abolition period, when a new configuration of exploitation and maintenance of social inequalities related to freed slaves and their descendants began. It is during adolescence, a phase of life linked to the social and cultural context, and not just determined by the chronological period of life, when black individuals generally begin to experience the stigma of race more consciously. This essay initially presents the historical path of the social construction of race in patterns of domination and racism. It then reflects, based on structural racism, on the role of monopoly capitalism in the development and economic growth of post-abolitionist Brazil, as one of the main mechanisms for recruiting and maintaining the black population in lower and marginalized social classes. Finally, it discusses how racism impacts the health of Brazilian Afro-descendant adolescents based on the ecosocial theory, proposed by Nancy Krieger, and representative bibliography. Structural racism in our society impacts the health of black adolescents, with a strong determination in the health-disease process; Therefore, it is necessary to combat historical disparities, to build a more democratic and egalitarian society. Afrodescendant Afro descendant postabolition post abolition began adolescence consciously reflects postabolitionist abolitionist Brazil classes Finally theory Krieger bibliography healthdisease disease process Therefore disparities

Resumo Objetivou-se refletir sobre o impacto do racismo estrutural na saúde dos adolescentes afrodescendentes brasileiros, considerando o contexto político e social do período pós-abolição, quando foi iniciada uma nova configuração de exploração e manutenção das desigualdades sociais relacionadas aos escravizados libertos e seus descendentes. É na adolescência, fase da vida ligada ao contexto social e cultural, e não apenas determinada pelo período cronológico da vida, quando geralmente o indivíduo negro começa a vivenciar de modo mais consciente o estigma da raça. Este ensaio, inicialmente, apresenta o percurso histórico da construção social da raça nos padrões de dominação e o racismo. Em seguida, reflete, balizado no racismo estrutural, sobre o papel do capitalismo monopolista no desenvolvimento e crescimento econômico do Brasil pós-abolicionista, como um dos principais mecanismos de recrutamento e manutenção da população negra nas classes sociais inferiores e marginalizadas. Por fim, discute como o racismo impacta a saúde dos adolescentes afrodescendentes brasileiros a partir da teoria ecossocial, proposta por Nancy Krieger, e de bibliografia representativa. O racismo estrutural em nossa sociedade impacta na saúde dos adolescentes negros, com forte determinação no processo de saúde-doença. Por isso, é preciso combater as disparidades históricas, no sentido de se construir uma sociedade mais democrática e igualitária. Objetivouse Objetivou pósabolição, pósabolição pós abolição, abolição pós-abolição descendentes adolescência cultural ensaio inicialmente seguida reflete pósabolicionista, pósabolicionista abolicionista, abolicionista pós-abolicionista marginalizadas fim ecossocial Krieger representativa negros saúdedoença. saúdedoença doença. doença saúde-doença isso históricas igualitária

It is particularly important to investigate the mechanical performance of carbon fiber (CF) reinforced polyamide 6 (PA6) composites used for automotive and aerospace applications, where diffused moisture of the environment may potentially weaken the material over time. In this work, CF/PA6 composites were subjected to two different types of conditioning: distilled water at a temperature of 80 ºC and saline solution for 12 weeks. The volumetric fraction of CF, PA6 matrix, and the voids of the CF/PA6 composites were determined by acid digestion analysis. At the end of the environmental conditionings, the moisture absorption content and the diffusion coefficient (D) were determined. The mechanical performance of CF/PA6 composites unconditioned and conditioned was evaluated through tensile and interlaminar shear strength (ILSS) tests, and morphological characteristics of the fracture surface after the mechanical tensile test. CF/PA6 composites conditioned in saline solution showed a decrease of 53% (tensile sample) and 72% (ILSS sample) in the diffusion coefficient (D) and insignificant losses of mechanical properties when compared to CF/PA6 composites conditioned in distilled water at 80 ºC. This behavior is attributed to the salt molecules blocking the pores and consequently reducing the migration of water into the samples, maintaining the internal integrity of the specimens. CF (CF PA (PA6 applications time work CFPA6 CFPA CF/PA conditioning 8 1 weeks matrix analysis conditionings D (D ILSS tests test 53 sample 72 samples specimens (PA 5 7

Abstract Objective: This meta-analysis of randomized controlled trials (RCTs) aimed to update evidence on the effectiveness and safety of laser therapy for treating genitourinary syndrome of menopause (GSM). Data sources: Manuscripts published until May 2023 were systematically searched in PubMed; Embase; Scopus; Web of Science; CENTRAL; CINAHL; and clinical trial databases (www.trialscentral.org, www.controlled-trials.com, and clinicaltrials.gov), with no language and year of publication restriction. Studies selection: RCTs with women diagnosed with GSM, and the intervention was vaginal laser therapy (CO2-laser or Er: YAG-laser) comparing with placebo (sham therapy), no treatment or vaginal estrogen therapy. Data collection: Two authors evaluated the publications for inclusion based on the title and abstract, followed by reviewing the relevant full-text articles. Disagreements during the review process were addressed by consensus, with the involvement of a third author. Data synthesis: Twelve RCTs, representing a total of 5147 participants, were included in this review. Vaginal health index (VHI) significantly improved in the carbon dioxide laser (CO2-laser) therapy group (MD=2.21; 95% CI=1.25 to 3.16), while dyspareunia (MD=−0.85; 95% CI=−1.59 to −0.10), dryness (MD=−0.62; 95% CI=−1.12 to −0.12) and burning (MD= −0.64; 95% CI=−1.28 to −0.01) decreased. No serious adverse effects were reported. Conclusion: CO2-laser increases VHI score and decreases dyspareunia, dryness and burning, especially when compared to sham-laser. However, the certainty of the evidence is low, thus preventing the recommendation of laser therapy for GSM management. Objective metaanalysis meta analysis (RCTs GSM. . (GSM) sources 202 PubMed Embase Scopus Science CENTRAL CINAHL www.trialscentral.org, wwwtrialscentralorg www trialscentral org (www.trialscentral.org www.controlledtrials.com, wwwcontrolledtrialscom www.controlled trials.com, com www.controlled-trials.com clinicaltrials.gov, clinicaltrialsgov clinicaltrials.gov , clinicaltrials gov clinicaltrials.gov) restriction selection CO2laser COlaser CO2 CO Er YAGlaser YAG YAG-laser sham therapy, therapy) collection abstract fulltext full text articles consensus author synthesis 514 participants (VHI MD=2.21 MD221 MD 2 21 (MD=2.21 95 CI125 CI 1 25 CI=1.2 3.16, 316 3.16 3 16 3.16) MD=−0.85 MD085 0 85 (MD=−0.85 CI159 59 CI=−1.5 −0.10, 010 −0.10 10 −0.10) MD=−0.62 MD062 62 (MD=−0.62 CI112 12 CI=−1.1 −0.12 012 MD= (MD −0.64 064 64 CI128 28 CI=−1.2 −0.01 001 01 decreased reported Conclusion shamlaser. shamlaser laser. sham-laser However low management (GSM 20 www.trialscentral.org controlledtrials www.controlledtrials.com wwwcontrolled trialscom trials.com 51 MD=2.2 MD22 (MD=2.2 9 CI12 CI=1. 31 3.1 MD=−0.8 MD08 8 (MD=−0.8 CI15 5 CI=−1. −0.1 MD=−0.6 MD06 6 (MD=−0.6 CI11 −0.6 06 −0.0 00 MD=2. MD2 (MD=2. CI1 CI=1 3. MD=−0. MD0 (MD=−0. CI=−1 −0. MD=2 (MD=2 CI= MD=−0 (MD=−0 CI=− −0 MD=− (MD=− −

ABSTRACT Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses within a 28-day interval. IC received two additional BNT162b2 doses and H received a third BNT162b2 dose (booster). Blood samples were collected at baseline, 28 days after each dose, pre-booster and at the trial end. We used three serological tests to detect antibodies to SARS-CoV-2 nucleocapsid (N), trimeric spike (S), and receptor binding domain (RBD). Outcomes included seroconversion rates (SCR), geometric mean titers (GMT) and GMT ratio (GMTR). A total of 241 IC and 100 H adults participated in the study. After two CoronaVac doses, IC had lower SCR than H: anti-N, 33.3% vs 79%; anti-S, 33.8% vs 86%, and anti-RBD, 48.5% vs 85%, respectively. IC also showed lower GMT than H: anti-N, 2.3 vs 15.1; anti-S, 58.8 vs 213.2 BAU/mL; and anti-RBD, 22.4 vs 168.0 U/mL, respectively. After the 3rd and 4th BNT162b2 doses, IC had significant anti-S and anti-RBD seroconversion, but still lower than H after the 3rd dose. After boosting, GMT increased in IC, but remained lower than in the H group. CoronaVac two-dose schedule immunogenicity was lower in IC than in H. BNT162b2 heterologous booster enhanced immune response in both groups. COVID19 COVID 19 COVID-1 scarce BNTb BNT b BNT162b (IC (H SOT, SOT , (SOT) cancer comparison 28day day interval booster. . (booster) baseline 2 prebooster pre end SARSCoV2 SARSCoV SARS CoV SARS-CoV- N, N (N) S, S (S) RBD. RBD (RBD) SCR, (SCR) (GMT GMTR. GMTR (GMTR) 24 10 study antiN, antiN anti anti-N 333 33 3 33.3 79% 79 antiS, antiS 338 8 33.8 86 86% antiRBD, antiRBD RBD, 485 48 5 48.5 85 85% respectively 23 2. 15.1 151 15 1 588 58 58. 2132 213 213. BAU/mL BAUmL BAU mL 224 22 4 22. 1680 168 0 168. UmL U U/mL rd th boosting twodose groups COVID1 COVID- (SOT (booster SARS-CoV (N (S (RBD (SCR (GMTR 33. 7 48. 15. 21 16

ABSTRACT The objective of this study was to examine the effect of the increasing levels of inclusion of palm kernel cake (PKC) in the diet on the performance of feedlot heifers. Forty-eight Nelore heifers with an initial weight of 274 ± 4.58 kg, at 24 months of age, were confined for 98 days in a feedlot. The animals were allocated to the four treatments in a completely randomized design. Treatments consisted of PKC levels of 0 (control), 10, 20, and 30% in the total dry matter of the diet. The roughage:concentrate ratio in the diets was 30:70. Ether extract intake increased, whereas the intakes of non-fiber carbohydrates and total digestible nutrients decreased with the inclusion of PKC. The apparent digestibility of all nutrients decreased, as well as the amounts of nitrogen digested and retained. Microbial protein synthesis and its efficiency also declined. The inclusion of up to 20% PKC increased feeding time and reduced rumination time of heifers. Intake and rumination efficiencies decreased with the inclusion of PKC in the diet. Final weight and average daily gain did not change, but feed efficiency increased with the inclusion of PKC. The inclusion of up to 30% PKC in the diet of feedlot heifers is recommended. (PKC Fortyeight Forty eight 27 458 4 58 4.5 kg 2 age 9 design control, control , (control) 10 20 30 roughageconcentrate roughage concentrate 3070. 3070 70. 70 30:70 nonfiber non fiber retained declined change recommended 45 5 4. (control 1 3 307 7 30:7 30:

RESUMO. Apesar do crescente conhecimento nos últimos anos, pouca atenção tem sido direcionada aos aspectos neuropsicológicos e à prevalência de declínio cognitivo associado à Síndrome de Vasoconstrição Cerebral Reversível (SVCR). Objetivo: Descrever a frequência e expandir o entendimento da disfunção cognitiva associada à SVCR. Métodos: A avaliação neuropsicológica foi realizada por meio de uma bateria composta de instrumentos neuropsicológicos específicos, que foram aplicados aos pacientes com SVCR. Uma triagem foi realizada para excluir outras potenciais causas de declínio cognitivo. O desempenho nos testes foi considerado como variável categórica, e o corte de −1,5 escore z foi adotado para indicar desempenho comprometido. Resultados: Sete pacientes com diagnóstico de SVCR foram avaliados, os quais tinham todos nível de ensino superior e pontuação normal no Miniexame do Estado Mental. A média de tempo entre o diagnóstico e a avaliação neuropsicológica foi de 1,8 ano. Dentre os pacientes, 85,6%(n=6) apresentaram desempenho comprometido em pelo menos dois dos testes aplicados. Especificamente, 71,4% (n=5) apresentaram alterações nos testes da Bateria Psicológica para Avaliação da Atenção, com comprometimento observado nas atenções concentrada (n=1), dividida (n=3), ou alternada (n=4). Além disso, 28,6% (n=2) demonstraram comprometimento na Fluência Verbal Fonológica, 28,6% (n=2) exibiram dificuldades na cópia da Figura Complexa de Rey e um paciente obteve desempenho alterado no Teste dos Cinco Dígitos, todos indicando disfunção executiva. Conclusão: Este estudo fornece evidência de que o declínio cognitivo associado à SVCR é mais prevalente do que se acreditava anteriormente. Especialmente, os domínios mais significativamente comprometidos foram a atenção e as funções executivas. RESUMO anos . (SVCR) Objetivo Métodos específicos categórica 15 1 5 −1, Resultados avaliados Mental 18 8 1, ano 85,6%n=6 856n6 n 85,6% n=6 85 6 85,6%(n=6 Especificamente 714 71 4 71,4 n=5 n5 (n=5 Atenção n=1, n1 n=1 , (n=1) n=3, n3 n=3 3 (n=3) n=4. n4 n=4 (n=4) disso 286 28 28,6 n=2 n2 2 (n=2 Fonológica Dígitos executiva Conclusão anteriormente Especialmente executivas (SVCR −1 85,6%n= 856n 856 85,6 n6 n= 85,6%(n= 7 71, (n= (n=1 (n=3 (n=4 28, − 85,6%n 85, 85,6%(n (n

ABSTRACT. Despite the increasing knowledge in the past years, only minimal attention has been directed to the neuropsychological aspects and the prevalence of cognitive impairment associated with reversible cerebral vasoconstriction syndrome (RCVS). Objective: To describe the frequency and expand the understanding of cognitive dysfunction in RCVS. Methods: The neuropsychological evaluation was performed using a battery consisting of specific neuropsychological instruments that were administered to patients diagnosed with RCVS. A triage was conducted to exclude other potential causes of cognitive impairment. Performance on the tests was treated as a categorical variable, and a cutoff of −1.5 Z-score was adopted to indicate impaired performance. Results: Seven patients diagnosed with RCVS were evaluated, all of whom had a bachelor's degree and normal score in the Mini-Mental State Examination. The average time between diagnosis and neuropsychological evaluation was 1.8 years. Among the patients, 85.6% (n=6) exhibited performance below that of the normal population in at least two of the administered tests. Specifically, 71.4% (n=5) showed alterations in tests from the Psychological Battery for Attention Assessment, with impairment observed in concentrated (n=1), divided (n=3), or alternating (n=4) attention. Furthermore, 28.6% (n=2) demonstrated impairments in the Phonological Verbal Fluency Task, another 28.6% (n=2) exhibited difficulties copying elements of the Rey Complex Figure, and 14.3% (n=1) displayed lower performance in the Five-Digit test, all indicating executive dysfunction. Conclusion: This study provides evidence that cognitive impairment associated with RCVS is more prevalent than previously believed and has not received sufficient attention. Specifically, attention and executive functions are the cognitive domains most significantly impacted by RCVS. ABSTRACT years . (RCVS) Objective Methods variable 15 1 5 −1. Zscore Z Results evaluated bachelors bachelor s MiniMental Mini Mental Examination 18 8 1. 856 85 6 85.6 n=6 n6 n (n=6 Specifically 714 71 4 71.4 n=5 n5 (n=5 Assessment n=1, n1 n=1 , n=3, n3 n=3 3 (n=3) n=4 n4 (n=4 Furthermore 286 28 28.6 n=2 n2 2 (n=2 Task Figure 143 14 14.3 (n=1 FiveDigit Five Digit test Conclusion (RCVS −1 85. n= (n= 7 71. (n=3 28. 14. − (n

RESUMO: O artigo tem como objetivo debater questões interpretativas de exegese sobre o texto do auto Na Festa de São Lourenço, de 1587, escrito pelo missionário e humanista S. José de Anchieta (1534-1597), no contexto da América portuguesa quinhentista. A obra foi encenada na comunidade indígena de São Lourenço em Niterói, ainda no século XVI, e é um dos principais registros da produção intelectual do período colonial. Modernamente, o texto do autor foi reeditado por Maria de Lourdes de Paula Martins, em um extenso volume com as Poesias de Anchieta (Anchieta, 1989 [1954]), e por Armando Cardoso, na edição dos Monumenta Anchietana (Anchieta, 1977). Nossa interpretação crítica terá como escopo retomar a análise desenvolvida por Câmara Cascudo, na obra Antologia do Folclore Brasileiro (2002 [1944]), em que cita os textos de Anchieta e de cronistas do século XVI como fonte para os estudos de folclore no Brasil. Buscamos problematizar como a interpretação folclórica aproxima-se ao método da exegese da disciplina de Crítica Textual. Por fim, em perspectiva interdisciplinar com a disciplina de Historiografia da Linguística, buscaremos evidenciar como o “pensamento linguístico” (linguistic thought) (Swiggers, 2013; 2019) de Anchieta estava vinculado ao estudo de tradições populares indígenas na América portuguesa quinhentista, o que conceituamos como um Folclore brasílico colonial. RESUMO 1587 S 15341597, 15341597 1534 1597 , (1534-1597) quinhentista Niterói colonial Modernamente Martins Anchieta, (Anchieta 198 1954, 1954 [1954]) Cardoso 1977. 1977 . 1977) Cascudo 2002 (200 1944, 1944 [1944]) Brasil aproximase aproxima se Textual fim Linguística pensamento linguístico linguistic thought Swiggers, Swiggers (Swiggers 2013 2019 158 1534159 153 159 (1534-1597 19 195 [1954] 197 200 (20 194 [1944] 201 15 153415 (1534-159 1 [1954 20 (2 [1944 15341 (1534-15 [195 2 ( [194 (1534-1 [19 (1534- [1 (1534 [ (153 (15 (1

ABSTRACT: The article aims to discuss interpretative exegesis questions about the text of the play Na Festa de São Lourenço, from 1587, written by the missionary and humanist S. José de Anchieta (1534-1597), in the context of sixteenth-century Portuguese America. The work was staged in the indigenous community of São Lourenço in Niterói, still in the 16th century, and is one of the main records of intellectual production in the colonial period. Modernly, the author's text has been republished by Maria de Lourdes de Paula Martins, in an extensive volume with Poesias de Anchieta (Anchieta, 1989 [1954]), and by Armando Cardoso, in the edition of Monumenta Anchietana (Anchieta, 1977). Our critical interpretation will have the scope of resuming the analysis developed by Câmara Cascudo, in the work Antologia do Folclore Brasileiro (2002 [1944]), in which the interpreter cites the texts of Anchieta and chroniclers of the 16th century as a source for folklore studies in Brazil. We seek to problematize how folkloric interpretation approaches the exegesis method of the Textual Criticism discipline. Finally, in an interdisciplinary perspective with the discipline of Historiography of Linguistics, we will seek to show how Anchieta’s “linguistic thought” (Swiggers, 2013; 2019) was linked to the study of indigenous popular traditions in sixteenth-century Portuguese America, which we conceptualize as a colonial Brazilian folkcore. ABSTRACT 1587 S 15341597, 15341597 1534 1597 , (1534-1597) sixteenthcentury sixteenth America Niterói th period Modernly authors author s Martins Anchieta, (Anchieta 198 1954, 1954 [1954]) Cardoso 1977. 1977 . 1977) Cascudo 2002 (200 1944, 1944 [1944]) Brazil Finally Linguistics Anchietas linguistic thought Swiggers, Swiggers (Swiggers 2013 2019 folkcore 158 1534159 153 159 (1534-1597 19 195 [1954] 197 200 (20 194 [1944] 201 15 153415 (1534-159 1 [1954 20 (2 [1944 15341 (1534-15 [195 2 ( [194 (1534-1 [19 (1534- [1 (1534 [ (153 (15 (1

RESUMO A maioria das pessoas com demência vive em países de baixa/média renda, onde recursos essenciais para a saúde cerebral, como educação de qualidade, ainda não são amplamente acessíveis. No Brasil, o analfabetismo ainda é frequente, especialmente em comunidades de baixo nível socioeconômico. O estudo PROAME teve como objetivo explorar a educação básica tardia em pessoas analfabetas como ferramenta para o aumento da reserva cognitiva. Objetivo: Investigar a relação entre nível socioeconômico com aprendizado e com desempenho em testes cognitivos, em adultos analfabetos. Métodos: Este estudo clínico de seis meses (NCT04473235) contou com 108 participantes inscritos no projeto Educação para Jovens e Adultos (EJA), dos quais 77 completaram os testes. O nível socioeconômico de cada participante foi medido usando-se: o Índice de Qualidade de Vida Urbana, o Índice de Desenvolvimento Humano Municipal e o nível socioeconômico doméstico. Avaliações cognitivas incluíram: o Teste de Recordação Seletiva Livre e Guiada (TRSLG), uma lista de palavras para avaliar leitura e a matriz Beta III. Resultados: A amostra era predominantemente feminina, com idade média de 58,5. Os participantes melhoraram a leitura (p=0,01) e o TRSLG (p=0,003). Com relação à memoria episódica, as mulheres tiveram resultados superiores aos dos homens (p=0,007) e participantes mais jovens melhoraram mais que seus colegas mais velhos (p=0,001). Não foi observada nenhuma relação entre o nível socioeconômico e o desempenho cognitivo. Conclusão: Independentemente do nível socioeconômico, participantes obtiveram resultados positivos após frequentar a educação básica. Isso sugere que a educação tardia pode ser uma medida preventiva não farmacológica importante, especialmente em países de baixa/média renda. baixamédia baixa renda cerebral qualidade acessíveis Brasil frequente cognitiva Objetivo cognitivos analfabetos Métodos NCT04473235 NCT (NCT04473235 10 EJA, EJA , (EJA) 7 usandose usando se usando-se Urbana doméstico incluíram TRSLG, (TRSLG) III Resultados feminina 585 58 5 58,5 p=0,01 p001 p 0 01 (p=0,01 p=0,003. p0003 p=0,003 . 003 (p=0,003) episódica p=0,007 p0007 007 (p=0,007 p=0,001. p0001 p=0,001 001 (p=0,001) cognitivo Conclusão importante NCT0447323 (NCT0447323 1 (EJA (TRSLG 58, p=0,0 p00 (p=0,0 p000 p=0,00 00 (p=0,003 (p=0,00 (p=0,001 NCT044732 (NCT044732 p=0, p0 (p=0, NCT04473 (NCT04473 p=0 (p=0 NCT0447 (NCT0447 p= (p= NCT044 (NCT044 (p NCT04 (NCT04 NCT0 (NCT0 (NCT

ABSTRACT The majority of people with dementia live in low or middle-income countries (LMICs) where resources that play a crucial role in brain health, such as quality education, are still not widely available. In Brazil, illiteracy remains a prevalent issue, especially in communities with lower socioeconomic status (SES). The PROAME study set out to explore basic education in illiterate adults as a means to improve cognitive reserve. Objective: This manuscript aims to explore the relationship between SES and learning, as well as cognitive outcomes, in an older illiterate population. Methods: This six-month clinical trial (NCT04473235) involved 108 participants, of which 77 concluded all assessments, enrolled in late-life basic education. SES assessments included Quality of Urban Living Index, Municipal Human Development Index and Household SES calculated for each participant. Cognitive assessments encompassed the Free and Cued Selective Reminding Test (FCSRT), a word list to assess reading, and the Beta III matrix. Results: The sample consisted primarily of women, with a mean age of 58.5. Participants improved their reading (p=0.01) and their FCSRT (p=0.003). Regarding episodic memory, women outperformed men (p=0.007) and younger participants improved more than their older counterparts (p=0.001). There was no association observed between SES and cognitive outcomes. Conclusion: Irrespective of SES, participants demonstrated positive outcomes after attending basic education. These findings highlight that late life education could be an important non-pharmacologic preventative measure, especially in LMICs. middleincome middle income LMICs (LMICs health available Brazil issue SES. . (SES) reserve Objective learning population Methods sixmonth six month NCT04473235 NCT (NCT04473235 10 7 latelife participant FCSRT, , (FCSRT) matrix Results 585 58 5 58.5 p=0.01 p001 p 0 01 (p=0.01 p=0.003. p0003 p=0.003 003 (p=0.003) memory p=0.007 p0007 007 (p=0.007 p=0.001. p0001 p=0.001 001 (p=0.001) Conclusion nonpharmacologic non pharmacologic measure (SES NCT0447323 (NCT0447323 1 (FCSRT 58. p=0.0 p00 (p=0.0 p000 p=0.00 00 (p=0.003 (p=0.00 (p=0.001 NCT044732 (NCT044732 p=0. p0 (p=0. NCT04473 (NCT04473 p=0 (p=0 NCT0447 (NCT0447 p= (p= NCT044 (NCT044 (p NCT04 (NCT04 NCT0 (NCT0 (NCT

RESUMEN Objetivo: comprender las perspectivas bioéticas sobre el uso de dispositivos móviles de seguimiento. Métodos: estudio teórico basado en la investigación acción, realizado con ocho estudiantes de posgrado de una universidad pública. Se utilizó un grupo focal, con metodología de análisis de contenido temático con estructura de libro de códigos, aprobada por el Comité de Ética en Investigación. Resultados: del análisis surgió la preocupación por el uso de dispositivos una vez terminada la pandemia. El uso o no del dispositivo, los derechos inherentes a la persona humana, la legislación y la eficacia de los métodos profundizan las interpretaciones, trasladando a los participantes de una concepción personalista del tema a una visión centrada en las implicaciones profesionales de los métodos. Consideraciones finales: el debate sobre el impacto del uso de dispositivos tecnológicos en la salud, especialmente aquellos que implican restricción de derechos que se refieren a la vida privada de las personas, implica una discusión profesional, además de la exigencia de reglas claras sobre el tema. Objetivo seguimiento Métodos acción pública focal códigos Investigación Resultados pandemia dispositivo humana interpretaciones finales salud personas profesional

RESUMO Objetivo: compreender as perspectivas bioéticas no uso de dispositivos móveis de rastreamento. Métodos: estudo teórico fundamentado através de pesquisa-ação, realizado com oito pós-graduandos de uma universidade pública. Utilizou-se grupo focal, com metodologia de análise de conteúdo temática com estrutura de codebook, aprovado pelo Comitê de Ética em Pesquisa. Resultados: a partir da análise, constatou-se uma preocupação sobre o uso dos dispositivos findada a pandemia. O uso ou não do dispositivo, direitos inerentes à pessoa humana, legislação e efetividade dos métodos aprofundam interpretações, passando os participantes de uma concepção personalista do tema a uma visão voltada a implicações profissionais sobre os métodos. Considerações finais: o debate sobre o impacto do uso de dispositivos tecnológicos na saúde, em especial os que impliquem restrição de direitos que se referem à vida privada do indivíduo, passa por uma discussão de caráter profissional, além da exigência de claro regramento sobre o tema. Objetivo rastreamento Métodos pesquisaação, pesquisaação pesquisa ação, ação pesquisa-ação pósgraduandos pós graduandos pública Utilizouse Utilizou focal codebook Pesquisa Resultados constatouse constatou pandemia dispositivo humana interpretações finais saúde indivíduo profissional

ABSTRACT Objective: to understand the bioethical perspectives on mobile tracking device use. Methods: theoretical study based on action research, carried out with eight graduate students from a public university. A focus group was used, with a thematic content analysis methodology with a codebook structure, approved by the Research Ethics Committee. Results: from the analysis, there was a concern about using devices after the pandemic ended. Using or not the device, rights inherent to humans, legislation and effectiveness of methods deepen interpretations, moving participants from a personalistic conception of the topic to a vision focused on professional implications about the methods. Final considerations: the debate on the impact of using technological devices on health, especially those that imply restriction of rights that refer to individuals’ private life, involves a discussion of a professional nature, in addition to requirement for clear rules on the topic. Objective use Methods research university used structure Committee Results ended humans interpretations considerations health individuals life nature