ABSTRACT Purpose: to analyze the quality of life and metamemory and verify their predictors in students during the COVID-19 pandemic. Methods: a cross-sectional survey carried out through online collection with the application of an initial questionnaire to characterize the sample, the WHOQOL-brief to investigate the quality of life, and the Metamemory Questionnaire in Adults (short version) - MIAr to evaluate metamemory in a group of undergraduate and postgraduate students. Data were analyzed using descriptive and inferential statistics. Multiple linear regression was performed to verify the predictor variables. A significance level of 5% (p ≤ 0.05) was considered. Results: 977 university students participated in the study, the majority (70.73%) of whom were females and with an income range below three minimum wages (63.56%). For quality of life, income range, being in the risk group for COVID-19, and age were predictors for both the undergraduate and postgraduate groups. In contrast, on an excellent metamemory, the predictors were male gender and age. Conclusion: for students, during the COVID-19 pandemic, the main predictor of quality of life was having a higher income bracket, and the main predictor of metamemory was being a male. Purpose COVID19 COVID 19 COVID-1 pandemic Methods crosssectional cross sectional sample WHOQOLbrief WHOQOL brief short version statistics variables 5 p 0.05 005 0 05 considered Results 97 study 70.73% 7073 70 73 (70.73% 63.56%. 6356 63.56% . 63 56 (63.56%) COVID19, 19, groups contrast Conclusion bracket COVID1 1 COVID- 0.0 00 9 70.73 707 7 (70.73 635 63.56 6 (63.56% 0. 70.7 (70.7 63.5 (63.56 70. (70. 63. (63.5 (70 (63. (7 (63 ( (6

RESUMO Objetivo: analisar a qualidade de vida e a metamemória e verificar seus preditores em estudantes durante a pandemia da COVID-19. Métodos: trata-se de uma pesquisa transversal realizada por meio de coleta online com a aplicação de um questionário inicial para caracterizar a amostra, do WHOQOL-bref para investigar a qualidade de vida e do Questionário de Metamemória em Adultos (versão reduzida) - MIAr para avaliar a metamemória, em um grupo de estudantes de graduação e outro de pós-graduação. Os dados foram analisados por meio de estatística descritiva e inferencial. Realizou-se a regressão linear múltipla para verificar as variáveis preditoras. Foi considerado o nível de significância de 5% (p≤0,05). Resultados: participaram do estudo 977 universitários, sendo a maioria (70,73%) do gênero feminino e com faixa de renda menor que três salários-mínimos (63,56%). Para a qualidade de vida, tanto para o grupo de graduandos quanto de pós-graduandos, a faixa de renda, o grupo de risco para COVID-19 e a idade foram preditores, enquanto para uma boa metamemória os preditores foram o gênero masculino e a idade. Conclusão: para os estudantes, durante a pandemia da COVID-19, o principal preditor da qualidade de vida foi possuir maior faixa de renda e o da metamemória foi ser do gênero masculino. Objetivo COVID19. COVID19 COVID 19. 19 Métodos tratase trata se amostra WHOQOLbref WHOQOL bref versão reduzida pósgraduação. pósgraduação pós graduação. pós-graduação inferencial Realizouse Realizou preditoras 5 p≤0,05. p005 p p≤0,05 . 0 05 (p≤0,05) Resultados 97 universitários 70,73% 7073 70 73 (70,73% saláriosmínimos salários mínimos 63,56%. 6356 63,56% 63 56 (63,56%) pósgraduandos, pósgraduandos graduandos, pós-graduandos COVID-1 Conclusão COVID19, 19, COVID1 1 p00 p≤0,0 (p≤0,05 9 70,73 707 7 (70,73 635 63,56 6 (63,56% COVID- p0 p≤0, (p≤0,0 70,7 (70,7 63,5 (63,56 p≤0 (p≤0, 70, (70, 63, (63,5 p≤ (p≤0 (70 (63, (p≤ (7 (63 (p ( (6

Abstract Introduction: Postoperative nausea and vomiting is still a common complication. Serotonin receptor antagonists are commonly used in clinical practice for antiemetic prophylaxis. Interin-dividual variations in drug response, including single nucleotide polymorphisms, are related to pharmacokinetic and pharmacodynamic changes in these drugs and may lead to a poor therapeutic response. This study aimed to evaluate the influence of CYP2D6 isoenzyme and ABCB1 gene polymorphisms on the frequency of postoperative nausea and vomiting with the use of ondansetron or palonosetron. Methods: A randomized, double-blind clinical trial including 82 women aged 60 years or over undergoing laparoscopic cholecystectomy was conducted. Patients were randomized to receive either ondansetron or palonosetron for postoperative nausea and vomiting prophylaxis. DNA was extracted from saliva. Genetic polymorphisms were analyzed by real-time polymerase chain reaction. The following polymorphisms were analyzed: rs3892097 C/T, rs1128503 A/G, rs16947A/G, rs1065852 A/G, rs1045642 A/G, rs2032582 C/A, and rs20325821 C/A. Results: Overall, vomiting, and severe nausea occurred in 22.5% and 57.5% of patients, respectively. In the palonosetron group, patients with the GG genotype (rs16947 A/G) experienced more severe nausea (p = 0.043). In the ondansetron group, patients with the M genotype (rs16947 A/G) presented mild nausea (p = 0.034), and those with the AA genotype (rs1065852 A/G) experienced more vomiting (p = 0.034). Conclusion: A low antiemetic response was observed with ondansetron in the presence of the AA genotype (rs16947 A/G) and the AA genotype (rs1065852 A/G), and a low therapeutic response was found with palonosetron in the presence of the GG genotype (rs16947 A/G) in laparoscopic cholecystectomy. Register: ClinicalTrials.gov. Introduction complication prophylaxis Interindividual Interin dividual CYPD CYP D CYP2D ABCB Methods doubleblind double blind 8 6 conducted saliva realtime real time reaction rs rs389209 CT C T C/T rs112850 AG G A/G rs16947AG rsAG rs16947A rs16947A/G rs106585 rs104564 rs203258 CA C/A Results Overall 225 22 5 22.5 575 57 57.5 respectively group rs16947 (rs1694 p 0.043. 0043 0.043 . 0 043 0.043) 0.034, 0034 0.034 , 034 0.034) (rs106585 0.034. Conclusion Register ClinicalTrialsgov ClinicalTrials gov ClinicalTrials.gov rs38920 rs11285 rsA rs10658 rs10456 rs20325 2 22. 57. rs1694 (rs169 004 0.04 04 003 0.03 03 (rs10658 rs3892 rs1128 rs1065 rs1045 rs2032 rs169 (rs16 00 0.0 (rs1065 rs389 rs112 rs106 rs104 rs203 rs16 (rs1 0. (rs106 rs38 rs11 rs10 rs20 rs1 (rs (rs10 rs3 rs2

Abstract To investigate the impact of cash transfer (CTs) on birth outcomes, including birth weight, low birth weight and prematurity, as well as child physical growth were included, as assessed by anthropometric indices in children under five years of age. Searching was performed using the PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus and Web of Science databases. Quantitative observational, experimental and quasi-experimental. Eleven studies were included in the review. The majority (81.8%) were carried out in low-and middle-income countries and most involved conditional CTs (63.6%). Four were clinical trials and seven were observational studies. Conditional CTs were found to be associated with a reduction in height-for-age (-0.14; 95%CI -0.27, -0.02); (OR 0.85; 95%CI 0.77-0.94); (OR = 0.44; 95%CI 0.19-0.98), a significantly reduced chance of low weight-for-age (OR = 0.16; 95%CI -0.11-0.43), low weight-for-height (OR = -0.68; 95%CI -1.14, -0.21), and low weight-for-age (OR = 0.27; 95%CI 0.10; 0.71). Unconditional CTs were associated with reduced birth weight (RR = 0.71; 95%CI 0.63-0.81; p < 0.0001) and preterm births (RR = 0.76; 95%CI 0.69-0.84; p < 0.0001). Conditional CTs can positively influence birth outcomes and child growth. (CTs prematurity age PubMedMedline PubMed Medline PubMed/Medline Embase LILACS Library databases quasiexperimental. quasiexperimental quasi experimental. quasi-experimental review 81.8% 818 81 8 (81.8% lowand middleincome middle income 63.6%. 636 63.6% . 63 6 (63.6%) heightforage height for 0.14 014 0 14 (-0.14 95CI CI 95 0.27, 027 27 -0.27 0.02 002 02 -0.02) OR 0.85 085 85 0.770.94 077094 0.77 0.94 77 94 0.77-0.94) 0.44 044 44 0.190.98, 019098 0.19 0.98 , 19 98 0.19-0.98) weightforage 0.16 016 16 0.110.43, 011043 0.11 0.43 11 43 -0.11-0.43) weightforheight 0.68 068 68 -0.68 1.14, 114 1 -1.14 0.21, 021 0.21 21 -0.21) 0.27 0.10 010 10 0.71. 071 0.71 71 0.71) RR 0.630.81 063081 0.63 0.81 0.63-0.81 0.0001 00001 0001 0.76 076 76 0.690.84 069084 0.69 0.84 69 84 0.69-0.84 0.0001. 81.8 (81.8 63.6 (63.6% 0.1 01 (-0.1 9 2 -0.2 0.0 00 -0.02 0.8 08 770 0.770.9 07709 077 0.7 094 0.9 7 0.77-0.94 0.4 04 4 190 0.190.98 01909 019 098 0.19-0.98 110 0.110.43 01104 011 043 -0.11-0.43 0.6 06 -0.6 1.14 -1.1 0.2 -0.21 07 630 0.630.8 06308 063 081 0.63-0.8 0.000 0000 000 690 0.690.8 06908 069 084 0.69-0.8 81. (81. 63. (63.6 0. (-0. -0. -0.0 0.770. 0770 09 0.77-0.9 0.190.9 0190 0.19-0.9 0.110.4 0110 -0.11-0.4 1.1 -1. 0.630. 0630 0.63-0. 0.00 0.690. 0690 0.69-0. (81 (63. (-0 -0 0.770 0.77-0. 0.190. 0.19-0. 0.110. -0.11-0. 1. -1 0.630 0.63-0 0.690 0.69-0 (8 (63 (- - 0.77-0 0.190 0.19-0 0.110 -0.11-0 0.63- 0.69- ( (6 0.77- 0.19- -0.11- -0.11 -0.1

Resumo Investigar o impacto dos programas de tranferência de renda (CTs) nos desfechos ao nascer, incluindo peso ao nascer, baixo peso ao nascer e prematuridade, e crescimento físico infantil, avaliado pelos índices antropométricos de crianças menores de cinco anos. Revisão sistemática realizada nas bases de dados PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus e Web of Science. Foram incluídos estudos quantitativos observacionais, experimentais e quasi-experimentais, com um total de 11 estudos na revisão. A maioria (81,8%) foi realizada em países de baixa e média rendas. Também na modalidade CT condicionais (63,6%). Quatro eram ensaios clínicos, e sete observacionais. Os CT condicionais estiveram associados a uma redução nos índices de altura-para-idade (-0,14; IC95% -0,27, -0,02); (OR 0,85; IC95% 0,77-0,94); (OR = 0,44; IC95% 0,19-0,98), redução significativa na chance de baixo peso-para-idade (OR = 0,16; IC95% -0,11-0,43), baixo peso-para-altura (OR = -0,68; IC95% -1,14, -0,21), e redução de peso para idade (OR = 0,27; IC95% 0,10; 0,71). CTs não condicionais foram associados à redução do baixo peso as nascer (RR = 0,71; IC95% 0,63-0,81; p < 0,0001), e de prematuros (RR = 0,76; IC95% 0,69-0,84; p < 0,0001). Os CTs condicionais podem influenciar positivamente os desfechos ao nascer e o crescimento infantil. (CTs prematuridade infantil anos PubMedMedline PubMed Medline PubMed/Medline Embase LILACS Library Science observacionais quasiexperimentais, quasiexperimentais quasi experimentais, quasi-experimentais 1 revisão 81,8% 818 81 8 (81,8% rendas 63,6%. 636 63,6% . 63 6 (63,6%) clínicos alturaparaidade altura 0,14 014 0 14 (-0,14 IC95 IC 0,27, 027 27 -0,27 0,02 002 02 -0,02) OR 0,85 085 85 0,770,94 077094 0,77 0,94 77 94 0,77-0,94) 0,44 044 44 0,190,98, 019098 0,19 0,98 , 19 98 0,19-0,98) pesoparaidade 0,16 016 16 0,110,43, 011043 0,11 0,43 43 -0,11-0,43) pesoparaaltura 0,68 068 68 -0,68 1,14, 114 -1,14 0,21, 021 0,21 21 -0,21) 0,27 0,10 010 10 0,71. 071 0,71 71 0,71) RR 0,630,81 063081 0,63 0,81 0,63-0,81 0,0001, 00001 0,0001 0001 0,0001) 0,76 076 76 0,690,84 069084 0,69 0,84 69 84 0,69-0,84 0,0001. 81,8 (81,8 63,6 (63,6% 0,1 01 (-0,1 IC9 2 -0,2 0,0 00 -0,02 0,8 08 770 0,770,9 07709 077 0,7 094 0,9 7 9 0,77-0,94 0,4 04 4 190 0,190,98 01909 019 098 0,19-0,98 110 0,110,43 01104 011 043 -0,11-0,43 0,6 06 -0,6 1,14 -1,1 0,2 -0,21 07 630 0,630,8 06308 063 081 0,63-0,8 0000 0,000 000 690 0,690,8 06908 069 084 0,69-0,8 81, (81, 63, (63,6 0, (-0, -0, -0,0 0,770, 0770 09 0,77-0,9 0,190,9 0190 0,19-0,9 0,110,4 0110 -0,11-0,4 1,1 -1, 0,630, 0630 0,63-0, 0,00 0,690, 0690 0,69-0, (81 (63, (-0 -0 0,770 0,77-0, 0,190, 0,19-0, 0,110, -0,11-0, 1, -1 0,630 0,63-0 0,690 0,69-0 (8 (63 (- - 0,77-0 0,190 0,19-0 0,110 -0,11-0 0,63- 0,69- ( (6 0,77- 0,19- -0,11- -0,11 -0,1

Resumo Investigar o impacto dos programas de tranferência de renda (CTs) nos desfechos ao nascer, incluindo peso ao nascer, baixo peso ao nascer e prematuridade, e crescimento físico infantil, avaliado pelos índices antropométricos de crianças menores de cinco anos. Revisão sistemática realizada nas bases de dados PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus e Web of Science. Foram incluídos estudos quantitativos observacionais, experimentais e quasi-experimentais, com um total de 11 estudos na revisão. A maioria (81,8%) foi realizada em países de baixa e média rendas. Também na modalidade CT condicionais (63,6%). Quatro eram ensaios clínicos, e sete observacionais. Os CT condicionais estiveram associados a uma redução nos índices de altura-para-idade (-0,14; IC95% -0,27, -0,02); (OR 0,85; IC95% 0,77-0,94); (OR = 0,44; IC95% 0,19-0,98), redução significativa na chance de baixo peso-para-idade (OR = 0,16; IC95% -0,11-0,43), baixo peso-para-altura (OR = -0,68; IC95% -1,14, -0,21), e redução de peso para idade (OR = 0,27; IC95% 0,10; 0,71). CTs não condicionais foram associados à redução do baixo peso as nascer (RR = 0,71; IC95% 0,63-0,81; p < 0,0001), e de prematuros (RR = 0,76; IC95% 0,69-0,84; p < 0,0001). Os CTs condicionais podem influenciar positivamente os desfechos ao nascer e o crescimento infantil.

Abstract To investigate the impact of cash transfer (CTs) on birth outcomes, including birth weight, low birth weight and prematurity, as well as child physical growth were included, as assessed by anthropometric indices in children under five years of age. Searching was performed using the PubMed/Medline, Embase, LILACS, Cochrane Library, Scopus and Web of Science databases. Quantitative observational, experimental and quasi-experimental. Eleven studies were included in the review. The majority (81.8%) were carried out in low-and middle-income countries and most involved conditional CTs (63.6%). Four were clinical trials and seven were observational studies. Conditional CTs were found to be associated with a reduction in height-for-age (-0.14; 95%CI -0.27, -0.02); (OR 0.85; 95%CI 0.77-0.94); (OR = 0.44; 95%CI 0.19-0.98), a significantly reduced chance of low weight-for-age (OR = 0.16; 95%CI -0.11-0.43), low weight-for-height (OR = -0.68; 95%CI -1.14, -0.21), and low weight-for-age (OR = 0.27; 95%CI 0.10; 0.71). Unconditional CTs were associated with reduced birth weight (RR = 0.71; 95%CI 0.63-0.81; p < 0.0001) and preterm births (RR = 0.76; 95%CI 0.69-0.84; p < 0.0001). Conditional CTs can positively influence birth outcomes and child growth.

ABSTRACT This study examined the effect of different supplementation strategies for ewes in the last third of gestation, kept on a deferred Brachiaria brizantha cv. Marandu pasture, on their performance and the growth curve of their lambs. A total of 54 ewes, of no defined breed, with an average weight of 41.10±3.10 kg, were used in a completely randomized design, divided into three groups (18 ewes per treatment). In total, 61 lambs were born, 28 females and 33 males, with 3.70±0.55 and 3.68±0.69 kg birth weight, respectively. Treatments were as follows: multiple mixture ad libitum, concentrate supplement at 0.4% live weight (LW), and concentrate supplement at 0.8% LW. Average daily weight gain (ADG, g/animal/day) and total weight gain (TWG, kg/animal) were evaluated in ewes and lambs. Reproductive efficiency indices were measured in the ewes and biometric variables in the lambs. The ADG and TWG of ewes in the last third of gestation were higher in animals supplemented at 0.8% LW. Reproductive efficiency results were superior in ewes supplemented at 0.4% LW. The effect of ewe supplementation on lamb growth curve as estimated by the Gompertz model did not reveal differences between the curves of lambs born to ewes that received supplementation at 0.4 and 0.8% LW. However, supplementing ewes with a multiple mixture induced a reduction in the growth curve parameters of their lambs. The use of concentrated supplementation, at levels of 0.4 and 0.8% of LW, provides greater productive and reproductive performance for ewes and lambs.

ABSTRACT Hereditary hyperferritinemia-cataract syndrome is a rare autosomal dominant disease caused by a genetic mutation in the iron responsive element in the 5’ untranslated region of the ferritin light chain gene. Hereditary hyperferritinemia-cataract syndrome is characterized by elevated serum ferritin levels and bilateral cataract development early in life and may be misdiagnosed as hemochromatosis. This case report describes a Brazilian family with a clinical diagnosis of hereditary hyperferritinemia-cataract syndrome, which was submitted to ferritin light chain gene sequencing. The genetic mutation c.-164C>G was identified in the 5’ untranslated region. In conclusion, genetic testing can be used for accurate diagnosis of hereditary hyperferritinemia-cataract syndrome to avoid misdiagnosis of hemochromatosis, other diseases associated with iron overload or ophthalmic diseases.

Resumo Objetivo: caracterizar as práticas sexuais dos adolescentes e sua associação com variáveis sociodemográficas, fontes de informações e hábitos comportamentais. Método: estudo descritivo observacional, transversal, conduzido com 85 adolescentes de escolas públicas de ensino fundamental e médio de um município do estado de São Paulo. Os dados foram coletados por meio de um questionário estruturado, autoaplicável e anônimo. A análise estatística realizada foi o teste do χ2 e teste de Fisher. Resultados: a iniciação da vida sexual foi de 21,2% através do sexo oral, com predominância o sexo feminino (94,4%), cor autorreferida parda (55,0%). A prática do sexo vaginal foi relatada em 31,8%, com idade média de iniciação aos 14,5 anos. O sexo feminino foi predominante (77,0%), com cor autorreferida parda (40,0%). A prática de sexo anal foi detectada em 7,1%, com média de idade aos 14,4 anos, prevalente no sexo feminino (83,3%), com cor autorreferida preta (50,0%). Ocorreu a associação entre o uso de álcool, drogas e tabaco com as práticas sexuais (p<0,05). Conclusão: detectou-se uma diversidade de práticas sexuais, associadas ao uso de substâncias, enfatizando a importância do papel do enfermeiro no planejamento e realização de intervenções de educação em saúde com os adolescentes e famílias.

Abstract Objective: to characterize adolescents’ sexual practices and their association with sociodemographic variables, sources of information and behavioral habits. Method: a descriptive, observational, cross-sectional study conducted with 85 adolescents from public elementary and high schools in a city in the state of São Paulo. Data were collected through a structured, self-administered and anonymous questionnaire. Statistical analysis was performed using the χ2 test and Fisher’s test. Results: 21.2% had started their sexual life through oral sex, with a predominance of females (94.4%), self-reported brown color (55.0%). The practice of vaginal sex was reported in 31.8%, with a mean age of initiation at 14.5 years. The female sex was predominant (77.0%), with a self-reported brown color (40.0%). The practice of anal sex was detected in 7.1%, with a mean age of 14.4 years, prevalent in females (83.3%), with a self-reported black color (50.0%). There was an association of alcohol, drugs and tobacco use with sexual practices (p<0.05). Conclusion: a diversity of sexual practices associated with substance use was detected, emphasizing the importance of the nurse’s role in planning and carrying out health education interventions with adolescents and families.

Resumen Objetivo: caracterizar las relaciones sexuales de los adolescentes y su relación con las variables sociodemográficas, fuentes de información y hábitos de comportamiento. Método: estudio descriptivo, observacional y transversal, realizado con 85 adolescentes de escuelas primarias y secundarias públicas de un municipio del estado de São Paulo. Los datos fueron recolectados a través de un cuestionario estructurado, autoadministrado y anónimo. El análisis estadístico se realizó mediante la prueba de χ2 y la prueba de Fisher. Resultados: el 21,2 % inició su vida sexual a través del sexo oral, con predominio del sexo femenino (94,4 %), y siendo autodeclarados pardos (55,0 %). Las relaciones sexuales con penetración vaginal fueron reportada en 31,8% y con una edad media de inicio de 14,5 años. Predominó el sexo femenino (77,0%) y siendo autodeclaradas pardas (40,0%). La práctica de sexo anal se detectó en el 7,1%, con una edad media de 14,4 años, prevaleciendo el sexo femenino (83,3%) y siendo autodeclarados negros (50,0%). Hubo correspondencia entre el uso de alcohol, drogas y tabaco con las relaciones sexuales (p<0,05). Conclusión: se detectó una diversidad de relaciones sexuales asociadas al uso de sustancias psicoactivas, destacando la importancia del papel del enfermero en la planificación y realización de reuniones conjuntas sobre educación sanitaria con adolescentes y familias.

Abstract INTRODUCTION: Leishmaniasis constitutes a serious but neglected tropical disease. Recently, socio-environmental, biological and physical changes have altered the range of leishmaniasis, causing it to spread into urban areas. In Minas Gerais, the disease is endemic, exhibiting regional differences and reaching urban centers. The purpose of this study was to evaluate entomological aspects related to the ecoepidemiology of leishmaniasis in Itaúna. METHODS: Monthly catches with HP traps were carried out from June 2017 to May 2018, in three ecological areas (urban, rural, and forest). The adaptability of the species to anthropic environments was assessed using the synanthropy index (SI). RESULTS: We collected 1306 specimens of phlebotomine sand flies. Of the species of medical importance, Lutzomyia longipalpis, the vector of Leishmania infantum, represented 90.4% of the specimens identified at species level (n=1260). Nyssomyia whitmani, the vector of Leishmania braziliensis, represented 1.6% of the total. Lu. longipalpis displayed an SI of +95.8, a value that denotes a marked preference for human environments. For Ny. whitmani, the SI was -25, expressing the tendency of this species to occupy uninhabited areas. The population of the three most numerous species captured increased with rain, high temperatures, and high relative humidity. Although captured at low numbers, Ny. whitmani showed a different profile concerning the climate variables analyzed. CONCLUSIONS: Understanding the epidemiology of the disease may assist the health services in formulating effective control measures for improving community health and contributing to the establishment of a dynamic relationship and a global awareness of the health/disease process.

Abstract INTRODUCTION: Canine visceral leishmaniasis (CVL) is an endemic disease in Brazil, and integrated control actions have been adopted by the Brazilian Ministry of Health to control its spread. However, the transmission profile is unknown in areas with recent CVL cases, including Itaúna, located in the Brazilian state of Minas Gerais, where the present study was carried out. METHODS: A total of 2,302 dogs from 12 neighborhoods were serologically tested for canine VL using the current diagnostic protocol adopted by the Brazilian Ministry of Health. Test positivity rate (TPR) and CVL prevalence were determined for each neighborhood. The presence of Leishmania was assessed in 60 seropositive dogs which had been recommended for euthanasia. Twenty-two of them (37%) were asymptomatic, and 38 (63%) were symptomatic for CVL. Parasitological (myeloculture and smear/imprint) and molecular (PCR) methods were employed for Leishmania detection in bone marrow, spleen, mesenteric lymph nodes, and ear skin. The infecting Leishmania species was identified by DNA sequencing. RESULTS: CVL prevalence (per 1,000 dogs) varied from 0.0-166.67, depending on the neighborhood, with a mean of 68.96 (SD 51.38). Leishmania DNA was detected in at least one tissue from all seropositive dogs, with comparable TPR among tissues. Leishmania parasites were identified in most (54/60) seropositive dogs, and the infecting parasite was identified as Leishmania infantum in all of these. CONCLUSIONS: Prevalence of CVL is a contributor to the spread of visceral leishmaniasis in Itaúna.

Resumo Políticos e profissionais de meio ambiente têm apontado para a ausência de conhecimento científico para embasamento da legislação que dispõe sobre o planejamento urbano. Assim, o intuito desse ensaio é disponibilizar conhecimento ecológico para auxiliar políticos e profissionais de meio ambiente na tomada de decisões relacionadas ao zoneamento urbano do Brasil. Como ciência, a ecologia disponibiliza o conhecimento necessário para auxiliar a criação de diretrizes e normas para o zoneamento urbano. Especificamente, a ecologia de paisagem aponta diferentes métodos de trabalho, que possuem parâmetros de qualificação e quantificação do ambiente urbano. Esses parâmetros podem ser utilizados como critérios para o planejamento de cidades sustentáveis. Já a ecologia urbana tem demonstrado a importância da conservação de áreas verdes e azuis (corpos de água) nas cidades, além da necessidade da formação de equipes transdisciplinares para uma gestão urbana e elaboração de políticas públicas que visem a estratégia de zoneamento sustentável. De modo geral, a ciência da ecologia demonstra contribuições que auxiliam na criação de diretrizes e normas para o zoneamento urbano brasileiro. As sugestões fornecidas através desse ensaio constituem um ponto de partida para a formulação de melhorias nas leis destinadas a desenvolver e fortalecer a legislação relativa ao zoneamento urbano brasileiro.

Abstract Politicians and environmental professionals have pointed to the lack of scientific knowledge to support legislation for planning urban centers. Thus, this essay aims to provide ecological knowledge to assist politicians and environmental professionals in decision making regarding the Brazilian urban zoning. As a science, ecology provides the necessary knowledge to assist the creation of guidelines and standards for urban zoning. Specifically, landscape ecology shows different methods of work, which have as parameters the qualification and quantification of urban environments. These parameters can be used as criteria for planning sustainable cities. The field of urban ecology has demonstrated the importance of conserving green and blue areas (water bodies) in cities, as well as the need for the formation of multidisciplinary teams for urban management and elaboration of public policies pointed to zoning sustainability strategies. Generally, ecology show contributions that assist in the creation of guidelines and norms for Brazilian urban zoning. The suggestions provided through this essay are a starting point for improving the formulation of laws designed to develop and strengthen the legislation on Brazilian urban zoning.

RESUMO Objetivo: Mensurar o grau de satisfação de profissionais de saúde quanto à usabilidade de um sistema de informação em saúde neonatal e identificar os fatores que podem influenciar na satisfação do usuário frente à usabilidade. Métodos: Estudo transversal e exploratório realizado com 50 profissionais de saúde integrantes dos centros da Rede Brasileira de Pesquisas Neonatais. Para avaliação da usabilidade foi utilizado o instrumento System Usability Scale entre fevereiro e março de 2017. Realizou-se a análise estatística descritiva e inferencial das variáveis coletadas, com a finalidade de descrever a amostra, quantificar o grau de satisfação dos usuários e identificar as variáveis associadas ao grau de satisfação do usuário em relação à usabilidade. Resultados: Da população avaliada, 75% era do sexo feminino, com idade média 52,8 anos, 58% com pós-graduação (doutorado); tempo médio da última formação de 17 anos; área de atuação em medicina (neonatologia), grau intermediário de conhecimento em informática e tempo de utilização média do sistema de 52 meses. Quanto à usabilidade, 94% avaliaram o sistema como “bom”, “excelente” ou “melhor impossível”. A usabilidade do sistema não foi associada a idade, sexo, escolaridade, profissão, área de atuação, nível de conhecimento em informática e tempo de uso do sistema. Conclusões: O grau de satisfação do usuário do sistema informatizado de saúde foi considerado bom. Não foram identificados fatores demográficos que influenciassem sua avaliação.

ABSTRACT Objective: To measure the level of satisfaction regarding the usability of a neonatal health information system and identify if demographic factors can influence the usability of a health information system. Methods: A cross-sectional, exploratory study was carried out with a convenience sample of 50 users of the Brazilian Neonatal Research Network. The instrument chosen for the usability evaluation was the System Usability Scale between February and March 2017. The statistical analysis of the collected variables was carried out in order to describe the sample, to quantify the level of satisfaction of the users and to identify the variables associated with the level of satisfaction. Results: The female gender represented 75% of the sample. The mean age was 52.8 years; 58% had a doctoral degree, average time of graduation was 17 years, with area of practice in medicine (neonatology), with intermediate knowledge in computer science (74%) and mean system use time of 52 months. Regarding usability, 94% rated the system as “good”, “excellent” or “better than imaginable”. The usability of the system was not associated with age, gender, education, profession, area of practice, knowledge in computer science and time of system use. Conclusion: The level of satisfaction of the computerized health system user was considered good. No demographic factors were associated with the satisfaction of the users.

Abstract INTRODUCTION: We assessed the clinical-epidemiological profile of acquired immune deficiency syndrome (AIDS) patients in the Santos region (São Paulo state) with the highest AIDS prevalence in Brazil. METHODS Information was extracted from records of 409 AIDS-infected patients hospitalized between 2011 and 2016. RESULTS: Human immunodeficiency virus (HIV) was diagnosed in 24.7% of patients during admission, and 39.6% of already diagnosed patients received highly active antiretroviral therapy (HAART) irregularly. The mortality rate was 19.1%, and the main secondary manifestations were neurotoxoplasmosis and tuberculosis. CONCLUSIONS: AIDS patients in the Santos region had high rates of late diagnosis and low treatment adherence.

RESUMO Objetivo: avaliar a eficácia do extrato de Baccharis dracunculifolia no tratamento de fístulas anais em ratos. Métodos: vinte ratos Wistar machos foram submetidos à confecção de fístula anal e, após 30 dias, foram distribuídos em três grupos: Grupo Controle, com cinco animais; Grupo Carbopol, com cinco animais; e Grupo Baccharis dracunculifolia, com dez animais. No Grupo Controle, não se realizou nenhum tratamento. No Grupo Carbopol, realizou-se infusão diária de carbopol, e no Grupo Baccharis dracunculifolia, infusão de extrato de Baccharis dracunculifolia com carbopol, ambos por 30 dias. Foram retirados espécimes para análise histológica após a eutanásia. Resultados: não houve fechamento completo do trajeto fistuloso em nenhum dos animais. A média da área do trajeto resultante foi de 847,2µm2, 565,6µm2 e 372,7µm2, respectivamente, nos Grupos Controle, Carbopol e Baccharis dracunculifolia (p=0,001). A média do escore de processo inflamatório foi de 2,4, 2,4 e 2,1, respectivamente, nos Grupos Controle, Carbopol e Baccharis dracunculifolia (p=0,285), enquanto a média de congestão vascular foi de 1,6, 1,4 e 1,1, respectivamente, nos Grupos Controle, Carbopol e Baccharis dracunculifolia (p=0,031). Conclusão: o extrato de Baccharis dracunculifolia foi capaz de reduzir o lúmen dos trajetos fistulosos e a congestão vascular, sem reduzir, no entanto, o processo inflamatório local ou fechar totalmente os trajetos fistulosos.

ABSTRACT Objective: to evaluate the efficacy of Baccharis dracunculifolia extract in the treatment of anal fistulas in rats. Methods: twenty male Wistar rats were submitted to anal fistula and, after 30 days, were divided into three groups: Control Group, with five animals; Carbopol Group, with five animals; and Baccharis dracunculifolia Group, with ten animals. In the Control Group, no treatment was performed. In the Carbopol Group, a daily infusion of Carbopol was performed for 30 days. In the Baccharis dracunculifolia Group, a daily infusion of Carbopol plus Baccharis dracunculifolia extract was performed for 30 days. Specimens were taken for histological analysis after euthanasia. Results: there was no complete closure of the fistulous tract in any of the animals. The mean area of the remaining tract was of 847.2µm2, 565.6µm2 and 372.7µm2, in the Control Group, Carbopol Group, and Baccharis dracunculifolia Group, respectively, (p=0.001). The mean of the inflammatory process score was of 2.4, 2.4, and 2.1, in the Control Group, Carbopol Group, and Baccharis dracunculifolia Group, respectively, (p=0.285), while the mean values of vascular congestion were of 1.6, 1.4, and 1.1, in the Control Group, Carbopol Group, and Baccharis dracunculifolia Group, respectively, (p=0.031). Conclusion: Baccharis dracunculifolia extract was able to reduce the lumen of the fistulous tracts and the degree of vascular congestion, without, however, reducing the local inflammatory process or totally closing the fistulous tracts.

RESUMO Objetivo Analisar a associação entre a qualidade de vida e a adesão ao tratamento farmacológico de pacientes com doença renal crônica. Métodos Utilizou-se o Short Form Health Survey para avaliar a qualidade de vida destes pacientes. O índice de complexidade terapêutico foi avaliado. O teste de Morisky-Green e o Brief Medication Questionnaire foram aplicados para avaliar a adesão a farmacoterapia. Resultados Nos 197 pacientes que participaram do estudo, o teste de Morisky-Green e o Brief Medication Questionnaire mostraram que a maioria deles apresentava baixa adesão ao tratamento (50,3% e 80,6%, respectivamente). A adesão esteve altamente associada ao sexo (masculino) e ligeiramente associada à complexidade da terapia, à saúde mental e aos aspectos sociais. Conclusão Observaram-se ligeira associação da adesão farmacoterapêutica com qualidade de vida e complexidade terapêutica, e forte associação com o sexo.

ABSTRACT Objective To analyzed the association of quality of life and compliance to drug treatment in chronic kidney disease patients. Methods The Short Form Health Survey was used to evaluate the quality of life of these patients, and the therapeutic complexity index was verified. The Morisky-Green test and the Brief Medication Questionnaire were applied to check compliance to drug therapy. Results A total of 197 patients were included. The Morisky-Green test and Brief Medication Questionnaire showed that most patients had low compliance to treatment (50.3% and 80.6%, respectively). Compliance was highly associated with gender (male) and slightly associated with complexity of therapy, mental health, and social aspects. Conclusion We observed a slight association between compliance to pharmacotherapy and quality of life and complexity of therapy, and a strong association with gender.