In this study, we aimed to investigate the anticancer activity of the extract, fractions, and isolated compounds of the flowers of Fridericia platyphylla, and to characterize the bioactive compounds. The chemical diversity of the extracts and fractions was investigated using liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). We were able to annotate 26 compounds from the classes of flavones, flavonols, flavanones, isoflavones, and cinnamic acid and its derivatives. The dichloromethane fraction showed greater cytotoxicity at a concentration of 100 µg mL−1. In addition, the inhibitory concentrations of the dichloromethane fraction were 22.14 and 30.9 µg mL−1 for MCF-7 and MDA-MB-231 cell lines, respectively, and were capable of inhibiting tumor cell migration. Brachydins A and C were isolated from the dichloromethane fraction and showed the greatest cytotoxicity. The results obtained from this study show the potential biological effect of F. platyphylla flowers as a possible antitumor pharmacological agent. extract LCHRMS. LCHRMS LC HRMS . (LC-HRMS) 2 flavones flavonols flavanones isoflavones derivatives 10 mL1 mL 1 addition 2214 22 14 22.1 309 30 9 30. mL− MCF7 MCF 7 MCF- MDAMB231 MDAMB MDA MB 231 MDA-MB-23 lines respectively migration F agent (LC-HRMS 221 22. 3 MDAMB23 23 MDA-MB-2 MDAMB2 MDA-MB- MDA-MB

Resumo Em um mundo globalizado, o controle do Legislativo sobre matérias ligadas ao Mercosul e à União Europeia importa, mas varia em relação às decisões de Política Externa Regional (PER). Este artigo investiga se existem configurações, considerando o desenho institucional, as condições políticas e os fatores econômicos, que expliquem a intensidade da participação legislativa na determinação de tais matérias. Foi realizada uma consulta com especialistas para selecionar 5 decisões que representaram mudanças significativas para a dinâmica regional dos países mercosulinos e europeus. Após definida a amostra intencional de casos, através de uma Análise Qualitativa Comparativa (QCA), foram identificadas condições causais, necessárias e suficientes, para a participação do Legislativo em PER. Os resultados indicam que desenho institucional e fatores econômicos importam, mas debates prévios nos Parlamentos sobre o tema também são relevantes para explicar a atuação legislativa. Isso foi corroborado por uma Análise de Coincidência que demonstrou que essa variável compõe a cadeia causal da participação. globalizado importa PER . (PER) configurações europeus casos QCA, QCA , (QCA) causais suficientes importam (PER (QCA

Abstract In a globalized world, Legislative control over matters related to Mercosur and the European Union (EU) is important. However, its importance varies according to Regional Foreign Policy (RFP) decisions. This article investigates whether there are configurations, considering institutional design, political conditions, and economic factors, which explain the intensity of legislative participation in determining such matters. Specialists were consulted to select five decisions that represented significant changes for the regional dynamics of Mercosur and EU member countries. After defining the intentional sample of cases, necessary and sufficient conditions for the participation of the Legislature in RFP were identified through a Qualitative Comparative Analysis (QCA). The results indicate that institutional design and economic factors matter, but prior debates in Parliaments on the subject are also relevant to explaining legislative action. This was corroborated by a Coincidence Analysis (CNA) that demonstrated that this variable makes up the causal chain of participation. world (EU important However (RFP configurations countries cases QCA. QCA . (QCA) matter action CNA (CNA (QCA

Resumen En un mundo globalizado, el control legislativo sobre los asuntos relacionados con el Mercosur y la Unión Europea es importante, pero varía en relación con las decisiones de Política Exterior Regional (PER). Este artículo investiga si existen configuraciones, teniendo en cuenta el diseño institucional, las condiciones políticas y los factores económicos, que expliquen la intensidad de la participación legislativa en la determinación de tales asuntos. Se consultó a expertos para seleccionar cinco decisiones que representaban cambios significativos en la dinámica regional del Mercosur y de los países europeos. Una vez definida la muestra intencional de casos, se utilizó un Análisis Cualitativo Comparativo (ACC) para identificar las condiciones causales necesarias y suficientes para la participación de la legislatura en PER. Los resultados indican que el diseño institucional y los factores económicos importan, pero los debates previos en los parlamentos sobre el tema también son relevantes para explicar la acción legislativa. Esto fue corroborado por un Análisis de Coincidencias que demostró que esta variable conforma la cadena causal de la participación. globalizado importante PER . (PER) configuraciones europeos casos ACC (ACC importan (PER

Résumé Dans un monde globalisé, le contrôle du législatif sur les questions liées au Mercosur et à l’Union Européenne est important, mais il varie en fonction des décisions de Politique Étrangère Régionale (PER). Cet article examine s’il existe des configurations, en tenant compte de la conception institutionnelle, des conditions politiques et des facteurs économiques, qui expliquent l’intensité de la participation législative dans la détermination de telles questions. Une consultation d’experts a été réalisée pour sélectionner 5 décisions représentant des changements significatifs pour la dynamique régionale des pays du Mercosur et de l’Union européenne. Après avoir défini l’échantillon intentionnel de cas, grâce à une Analyse Qualitative Comparative (QCA), des conditions causales, nécessaires et suffisantes, ont été identifiées pour la participation du législatif à la PER. Les résultats indiquent que la conception institutionnelle et les facteurs économiques importent, mais les débats préalables dans les Parlements sur le sujet sont également pertinents pour expliquer l’action législative. Cela a été corroboré par une Analyse de Coïncidence qui a démontré que cette variable fait partie de la chaîne causale de la participation. globalisé lUnion l Union important PER . (PER) sil s configurations lintensité intensité dexperts d experts européenne léchantillon échantillon cas QCA, QCA , (QCA) causales suffisantes importent laction action (PER (QCA

A growing body of literature suggests that the platformization of the public sphere is eroding the public debate, thus potentially leading to the fragmentation of the public sphere. While there exists mounting evidences supporting this perspective there also exists a substantial body of literature that suggests otherwise. Within this realm of mixed evidence, studies on climate change visibility play a prominent role, presenting findings that both weaken and reinforce the fragmentation hypothesis. To investigate this matter in a context conducive for a fragmented public sphere, we collected a longitudinal (2014-2022) and cross-platform (Instagram, Facebook and Twitter) dataset (n=794.281) and correlated it with a secondary database on the press coverage of climate change in Brazil (n=3.490). Our analysis reveals a robust positive correlation between these datasets, indicating that the Brazilian public sphere retains the capacity to interconnect various arenas of visibility. We argue that this finding is particularly significant, given that it emanates from a case characterized by circumstances favoring a high degree of public sphere fragmentation. Consequently, our discovery lends support to a less pessimistic assessment of the influence of platformization on political communication within the deliberative system. debate otherwise evidence role hypothesis 20142022 2014 2022 (2014-2022 crossplatform cross platform Instagram, Instagram (Instagram Twitter n=794.281 n794281 n 794 281 (n=794.281 n=3.490. n3490 n=3.490 . 3 490 (n=3.490) datasets significant Consequently system 2014202 201 202 (2014-202 n=794.28 n79428 79 28 (n=794.28 n349 n=3.49 49 (n=3.490 201420 20 (2014-20 n=794.2 n7942 7 2 (n=794.2 n34 n=3.4 4 (n=3.49 20142 (2014-2 n=794. n794 (n=794. n3 n=3. (n=3.4 (2014- n=794 n79 (n=794 n=3 (n=3. (2014 n=79 n7 (n=79 n= (n=3 (201 n=7 (n=7 (n= (20 (n (2 (

Hair can provide chemical information about drug use. This study employed matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) to detect drugs in hair samples. The technique was used to detect cocaine (COC, molecular weight (Mw) = 303.14 Da) and its main metabolites, benzoylecgonine (BZE, Mw = 289.13 Da), cocaethylene (COCE, Mw = 317.16 Da) and ecgonine methyl ester (EME, Mw = 199.12 Da) in hair strands using 2,5-dihydroxybenzoic acid (DHB, 7.0 mg mL-1) and α-cyano-4-hydroxycinnamic acid (CHCA, at concentrations of 1.5, 3.0, 7.0, and 10 mg mL-1) as the evaluated matrices. Among these, CHCA was selected. Subsequently, the qualitative results obtained by MALDI(+) MS were correlated with the quantitative analyses of gas chromatography-mass spectrometry (GC-MS), demonstrating a significant correlation in responses (70%), with the detection of analytes by MALDI(+) MS even at low concentrations, determined by GC-MS. The concentration ranges obtained by GC MS analysis were from 0.6 to 4.1 ng mg-1 of COC, and from 0.05 to 0.4 ng mg-1 of COCE. The effect of pre-washing on the detection of COC and its metabolites was also evaluated, and the results indicated less influence from the pre-washing stage and confirmed the reduction in COC detection in hair exposed to bleaching. use matrixassisted matrix assisted MALDIMS MALDI (MALDI-MS samples (COC (Mw 30314 303 14 303.1 Da BZE, BZE (BZE 28913 289 13 289.1 Da, , COCE, COCE (COCE 31716 317 16 317.1 EME, EME (EME 19912 199 12 199.1 2,5dihydroxybenzoic 25dihydroxybenzoic dihydroxybenzoic 2,5 2 5 DHB, DHB (DHB 70 7 0 7. mL1 mL 1 mL-1 αcyano4hydroxycinnamic αcyanohydroxycinnamic α cyano 4 hydroxycinnamic CHCA, (CHCA 15 1.5 30 3 3.0 matrices these selected Subsequently MALDI+ + MALDI(+ chromatographymass chromatography GCMS, GCMS (GC-MS) 70%, 70% (70%) GCMS. MS. GC-MS 06 6 0. 41 4. mg1 mg- 005 05 0.0 04 prewashing pre washing bleaching 3031 303. 2891 28 289. 3171 31 317. 1991 19 199. 5dihydroxybenzoic 25 2, mL- αcyano 1. 3. MALDI( (GC-MS (70% 00 (70 (7 (

RESUMO Neste trabalho, destacam-se aprendizados com pesquisa realizada pelo Núcleo Ecologias e Encontros de Saberes para a Promoção Emancipatória da Saúde (Neepes) em parceria com o Centro de Integração na Serra da Misericórdia (CEM) e o Movimento dos Sem Teto da Bahia (MSTB), que atuam em territórios periféricos no Rio de Janeiro e em Salvador. A pesquisa buscou apoiar e sistematizar conhecimentos e práticas emancipatórias de promoção da saúde protagonizados por essas experiências, tendo por base quatro eixos temáticos transversais: alimentação, cuidado, moradia e proteção ambiental, além de comunicação. No artigo, enfocaram-se as reflexões coletivas em relação ao primeiro eixo temático, envolvendo estratégias para promover agroecologia e soberania alimentar, com experiências de produção, circulação e acesso a alimentos saudáveis. Com base nessas reflexões, visou-se contribuir com discussões sobre Territórios Sustentáveis e Saudáveis (TSS), especialmente pelos aprendizados possibilitados com a sistematização das experiências territoriais com base na noção de Promoção Emancipatória da Saúde, que aponta para importantes aportes nas dimensões de justiça ambiental e cognitiva. Com a sistematização dessas experiências, destaca-se sua capacidade de resistir, a partir de um movimento de reexistência de saberes tradicionais e comunitários em periferias urbanas, que apontam caminhos possíveis para a construção de TSS em periferias urbanas. trabalho destacamse destacam se Neepes (Neepes CEM (CEM MSTB, MSTB , (MSTB) Salvador transversais alimentação cuidado comunicação artigo enfocaramse enfocaram temático alimentar produção saudáveis visouse visou TSS, (TSS) cognitiva destacase destaca resistir urbanas (MSTB (TSS

ABSTRACT In this work, we highlight lessons learned from research carried out by the Nucleus Ecologies and Encounters of Knowledge for Emancipatory Health Promotion (NEEPES) in partnership with the Center of Integration in Serra da Misericórdia (CEM) and the Movement of Homeless People of Bahia (MSTB), in peripheral territories in Rio de Janeiro and Salvador. The research sought to support and systematize knowledge and emancipatory practices of health promotion carried out by these experiences, based on four transversal thematic axes: food, care, housing and environmental protection, in addition to communication. The article focused on collective reflections on the first thematic axis, involving strategies to promote agroecology and food sovereignty, with experiences of production, circulation, and access to healthy food. Based on these reflections, we aim to contribute to discussions regarding the idea of Sustainable and Healthy Territories (SHT), especially through the lessons learned from the systematization of territorial experiences based on the notion of Emancipatory Health Promotion, which points to important contributions from the dimensions of environmental and cognitive justice. The systematization of these experiences highlights a movement of re-existence of traditional and community knowledge, which points to possible paths for the construction of SHT in urban peripheries. work NEEPES (NEEPES CEM (CEM MSTB, MSTB , (MSTB) Salvador axes care protection communication axis sovereignty production circulation SHT, (SHT) justice reexistence re existence peripheries (MSTB (SHT

Resumen Objetivo: Describir las características acústicas, calidad vocal, fatiga y carga vocal de profesores universitarios. Métodos: Estudio exploratorio, observacional, longitudinal, descriptivo con un solo grupo de participantes y datos de monitoreo vocal durante dos semanas. Se realizó caracterización acústica de la sala, evaluación auditiva-perceptiva y acústica de muestras de voz antes y después de las clases. Se realizó dosimetría vocal durante las clases y se verificó el Índice de Fatiga Vocal (IFV) en dos semanas. Se realizó un análisis descriptivo de los hallazgos y una prueba de aleatorización para verificar la confiabilidad interna del juez. Resultados: Todos los participantes informaron hablar en voz alta en clase, la mayoría informó cambios vocales en los últimos seis meses y solo uno informó cambios vocales actuales. La sala presentó mediciones y estimaciones acústicas fuera de las normas establecidas. Los profesores utilizaron intensidades vocales altas durante las clases. Hubo un aumento en los valores absolutos de los datos agrupados para CAPE-V, jitter y frecuencia fundamental, variando dentro de los límites normales, después de las clases. La intensidad después de las clases y el IFV, en la comparación entre las dos semanas, mostraron un aumento. Conclusiones: La dosis vocal y el IFV posiblemente se vieron afectados por la acústica del aula. El aumento del IFV medio entre semanas pudo deberse a la sensación de cansancio acumulada. Se sugieren nuevas investigaciones con un mayor número de participantes y que se realicen en la sala acondicionada acústicamente para evaluar propuestas de intervención colectiva, con el objetivo de reducir la carga vocal de los docentes.

Abstract Purpose: To describe the acoustic characteristics of a classroom, voice quality, fatigue, and vocal load of university professors. Methods: Exploratory, observational, longitudinal, and descriptive study with a single group of participants, including vocal monitoring data over two weeks. Acoustic characterization of the classroom, perceptual-auditory evaluation, and acoustic analysis of voice samples were conducted before and after classes. Vocal dosimetry was performed during classes, and the Vocal Fatigue Index (VFI) was assessed at the beginning of each week. Descriptive analysis of the findings was conducted, and randomization test was performed to verify the internal reliability of the judge. Results: All participants reported speaking loudly in the classroom, with the majority reporting vocal changes in the past six months, and only one participant reported a current vocal change. The classroom had acoustical measures and estimations that deviated from established standards. The professors used high vocal intensities during classes. After the classes, an increase in the absolute values of the aggregated data for CAPE-V, jitter, and fundamental frequency was found, varying within the range of normality. Furthermore, there was an observed increase in both post-lesson intensity and VFI when comparing the two-week period. Conclusions: Vocal intensities and VFI were possibly impacted by the acoustics of the classroom. The increase in average VFI between the weeks may be attributed to a cumulative fatigue sensation. Further research with a larger number of participants and in acoustically conditioned classrooms is suggested in order to evaluate collective intervention proposals aimed at reducing the vocal load on teachers.

RESUMO O objetivo principal deste artigo é analisar a corrupção no setor educacional no Brasil. Ao encontro desse objetivo, foi construído um índice de corrupção no setor educacional para os municípios brasileiros e, a partir dele, verificados seus determinantes em um modelo econométrico, com as variáveis explicativas dispostas em quatro dimensões: (i) institucional; (ii) administrativa e gestão pública; (iii) transparência pública, e (iv) geográfica, econômica e social, como variáveis de controle. A principal referência de dados foram os Relatórios do Programa de Fiscalização de Municípios da Controladoria-Geral da União (CGU). Entre as principais evidências empíricas encontradas, corrobora-se a hipótese de que municípios com menor nível de desenvolvimento e escolaridade e, por conseguinte, com controle social mais deficiente são os mais vulneráveis à ocorrência de irregularidades com recursos públicos. De outra parte, os resultados obtidos confirmam a importância do fomento à transparência da gestão pública como mecanismo inibidor da corrupção e como ferramenta de auxílio ao seu controle. CLASSIFICAÇÃO JEL H76, K42, O11, R51 CONTEÚDO Introdução; 1. Uma breve revisão da literatura e do estado da arte sobre a temática da corrupção; 2. Estratégia empírica; 3. Resultados empíricos; 4. Considerações finais; Referências Bibliográficas.

RESUMEN El principal objetivo de este artículo es analizar la corrupción en el sector educativo en Brasil. Para cumplir con este objetivo, se construyó un índice de corrupción en el área de educación para los municipios brasileños y a partir de él se verificaron sus determinantes en un modelo econométrico, con las variables explicativas dispuestas en cuatro dimensiones: (i) institucional; (ii) gestión administrativa y pública; (iii) transparencia publica, y (iv) factores geográficos, económicos y sociales. La principal referencia de datos fueron los Informes del Programa de Inspección Municipal de la Contraloría General de la Unión (CGU). Entre las principales evidencias empíricas encontradas, se corrobora la hipótesis de que los municipios con menor nivel de desarrollo y educación y, por tanto, con más deficiente control social, son los más vulnerables a la ocurrencia de irregularidades con los recursos públicos. Por otro lado, los resultados obtenidos confirman la importancia de promover la transparencia en la gestión pública como mecanismo para inhibir la corrupción y como herramienta para ayudar a controlarla. CLASIFICACIÓN JEL H76, K42, O11, R51 CONTENIDO Introducción; 1. Una breve revisión de la literatura y el estado del arte sobre el tema de corrupción; 2. Estrategia empírica; 3. Resultados empíricos; 4. Consideraciones finales; Referencias bibliográficas.

ABSTRACT The main objective of this article is to analyze the corruption in the educational sector in Brazil. To meet this objective, an index of corruption in education was developed for Brazilian municipalities and from this its determinants were verified in an econometric model, with the explanatory variables arranged in four dimensions: (i) institutional; (ii) administrative and public management; (iii) public transparency, and (iv) geographic, economic, and social. The main data reference used was the Reports of the Municipal Inspection Program of the Comptroller General of the Union (CGU). Among the main empirical evidence found, the hypothesis is corroborated that municipalities with a lower level of development and education and, therefore, with more deficient social control are the most vulnerable to the occurrence of irregularities with public resources. On the other hand, the results obtained confirm the importance of promoting transparency in public management as a mechanism to inhibit corruption and as a tool to help controlling it. JEL CLASSIFICATION H76, K42, O11, R51 CONTENT Introduction; 1. A brief review of the literature and state of the art about corruption; 2. Empirical Strategy; 3. Empirical Results; 4. Final Considerations; Bibliographic References.

Resumo Introdução: Doenças cardiovasculares são uma causa significativa de morte em pacientes com Doença Renal Crônica (DRC). A calcificação valvar é preditor de mortalidade cardiovascular e doença arterial coronariana. Objetivo: Avaliar a frequência, fatores associados e progressão de valvopatias em pacientes com DRC. Métodos: Coorte retrospectiva com 291 pacientes ambulatoriais no Hospital das Clínicas de Pernambuco. Inclusão: ≥18 anos com DRC e valvopatia; exclusão: tratamento conservador ou dados incompletos. Variáveis clínicas e laboratoriais foram comparadas e categorizadas por tempo de terapia dialítica (TTD): <5 anos, 5–10 anos, >10 anos. Foram aplicados os testes Qui-quadrado, exato de Fisher, ANOVA, Kruskal-Wallis. Associação entre valvopatia e TTD foi avaliada por regressão binária. Significância foi definida como p < 0,05. Resultados: A valvopatia mitral foi encontrada em 82,5% (240) dos casos, seguida da aórtica (65,6%; 86). Houve progressão da doença valvar em 106 (36,4%) pacientes. Não houve associação entre valvopatias aórtica, pulmonar, mitral ou tricúspide e TTD. Hiperparatireoidismo secundário foi a única variável explicativa significativa na regressão para valvopatia mitral (OR 2,59 [IC95%: 1,09–6,18]; p = 0,031). Conclusão: Encontramos alta frequência de valvopatias, especialmente mitral e aórtica, aem pacientes com DRC. Não houve associação entre TTD e valvopatia. Introdução . (DRC) coronariana Objetivo Métodos 29 Pernambuco Inclusão 18 ≥1 exclusão incompletos (TTD) 5 510 10 5–1 >1 Quiquadrado, Quiquadrado Qui quadrado, quadrado Qui-quadrado Fisher ANOVA KruskalWallis. KruskalWallis Kruskal Wallis. Wallis Kruskal-Wallis binária 005 0 05 0,05 Resultados 825 82 82,5 240 (240 casos 65,6% 656 65 6 (65,6% 86. 86 86) 36,4% 364 36 4 (36,4% pulmonar OR 259 2 59 2,5 IC95% IC95 IC [IC95% 1,09–6,18 109618 1 09 1,09–6,18] 0,031. 0031 0,031 031 0,031) Conclusão (DRC ≥ (TTD 51 5– > 00 0,0 8 82, 24 (24 65,6 (65,6 36,4 3 (36,4 25 2, IC9 [IC95 1,09–6,1 10961 003 0,03 03 0, (2 65, (65, 36, (36, [IC9 1,09–6, 1096 ( (65 (36 [IC 1,09–6 109 (6 (3 1,09– 1,09 1,0 1,

Abstract Introduction: Cardiovascular disease is an important cause of death among patients with chronic kidney disease (CKD). Valve calcification is a predictor of cardiovascular mortality and coronary artery disease. Objective: To assess heart valve disease frequency, associated factors, and progression in CKD patients. Methods: We conducted a retrospective study on 291 CKD patients at Hospital das Clínicas de Pernambuco. Inclusion criteria were age ≥ 18 with CKD and valve disease, while those on conservative management or with missing data were excluded. Clinical and laboratory variables were compared, and patients were categorized by dialysis duration (<5 years; 5–10 years; >10 years). Statistical tests, including chi-square, Fisher’s exact, ANOVA, and Kruskal-Wallis, were employed as needed. Simple and multivariate binary regression models were used to analyze valve disease associations with dialysis duration. Significance was defined as p < 0.05. Results: Mitral valve disease was present in 82.5% (240) of patients, followed by aortic valve disease (65.6%; 86). Over time, 106 (36.4%) patients developed valve disease. No significant association was found between aortic, pulmonary, mitral, or tricuspid valve disease and dialysis duration. Secondary hyperparathyroidism was the sole statistically significant factor for mitral valve disease in the regression model (OR 2.59 [95% CI: 1.09–6.18]; p = 0.031). Conclusion: CKD patients on renal replacement therapy exhibit a high frequency of valve disease, particularly mitral and aortic valve disease. However, no link was established between dialysis duration and valve disease occurrence or progression. Introduction CKD. . (CKD) Objective factors Methods 29 Pernambuco 1 excluded compared <5 5 (< years 510 10 5–1 >1 years. years) tests chisquare, chisquare chi square, square chi-square Fishers Fisher s exact ANOVA KruskalWallis, KruskalWallis Kruskal Wallis, Wallis Kruskal-Wallis needed 005 0 05 0.05 Results 825 82 82.5 240 (240 65.6% 656 65 6 (65.6% 86. 86 86) time 36.4% 364 36 4 (36.4% pulmonary OR 259 2 59 2.5 95% 95 [95 CI 1.09–6.18 109618 09 1.09–6.18] 0.031. 0031 0.031 031 0.031) Conclusion However (CKD ( 51 5– > 00 0.0 8 82. 24 (24 65.6 (65.6 36.4 3 (36.4 25 2. 9 [9 1.09–6.1 10961 003 0.03 03 0. (2 65. (65. 36. (36. [ 1.09–6. 1096 (65 (36 1.09–6 109 (6 (3 1.09– 1.09 1.0 1.

Abstract This research paper focuses on the use of murumuru husk ash (MHA), an agro-industrial waste generated specifically in the Amazon region, as partial replacement of cement in structural concrete. It also evaluates the physical, chemical and mineralogical characteristics of the ash to act as filler in concrete and its properties in the fresh and hardened states in concrete. To this end, the MHA performed physical-mechanical characterization tests, such as specific mass, pozzolanic activity with Portland cement, pozzolanic activity with lime, and BET test, also performing the mineralogical and chemical analysis of the ash. The results showed that there is technical feasibility with partial replacement of 6% of MHA in cement using plasticizer additive to improve workability, thus showing an improvement in the physical-mechanical and durability properties of the concrete.

Resumo O estudo objetiva pesquisar o uso da cinza da casca do murumuru (CCM), um resíduo agroindustrial gerado especificamente na região amazônica como substituição parcial do cimento no concreto estrutural e avaliar as características físicas, químicas e mineralógicas da cinza para atuação como filler no concreto, além de suas propriedades no estado fresco e endurecido no concreto. Com esse intuito, o CCM passou pelos ensaios de caracterização físico-mecânicas como o de massa específica, atividade pozolânica com cimento Portland, atividade pozolânica com a cal e ensaio de BET, realizando-se também as análises mineralógicas e químicas da cinza. Os resultados mostraram que existe uma viabilidade técnica com substituição parcial de 6% de CCM no cimento, utilizando-se aditivo plastificante para melhorar a trabalhabilidade, mostrando uma melhora nas propriedades físico-mecânicas e de durabilidade do concreto.

Resumo Este artigo teve como objetivo investigar a relação entre a incerteza da política econômica e a dívida de longo e curto prazo das empresas brasileiras negociadas na bolsa de valores Brasil, Bolsa, Balcão (B3). A discrepância entre os resultados anteriores levanta questões sobre o entendimento atual da relação entre a dívida e a incerteza da política econômica. Análises separadas de dívidas de longo e curto prazo fornecem insights diferentes sobre como as decisões corporativas são afetadas. Essa discrepância desafia nosso entendimento atual da complexa dinâmica entre a dívida e a incerteza da política econômica. A amostra da pesquisa consiste em 163 empresas brasileiras listadas na B3 entre 2010 e 2019, com periodicidade trimestral. Os modelos de linha de base consideraram a dívida de longo e curto prazo como endógena, levando em conta as características da empresa e do país. Empregamos uma abordagem de painel de dois estágios do método dos momentos generalizado sistêmico (generalized method of moments - GMM-sys) para lidar com a possível endogeneidade nas estimativas. Como o mercado de dívida desempenha um papel crucial na avaliação e no desempenho das empresas, é cada vez mais importante estudar a dinâmica da dívida corporativa de longo e curto prazo em meio aos desafios desencadeados pela disseminação da incerteza da política econômica no ambiente de negócios. Esclarecer como as dívidas de longo e curto prazo se comportam sob essa pressão é particularmente relevante, pois reforça as implicações já observadas e potenciais para a adaptabilidade corporativa no uso de fundos externos. O impacto deste estudo está em revelar a coexistência das decisões cautelosas das empresas na busca de fundos representativos e a posição conservadora dos investimentos corporativos em relação às incertezas que cercam a política econômica. Os resultados sugerem que níveis mais altos de incerteza da política econômica estão associados a uma diminuição no uso de dívidas de longo prazo e a um aumento nas dívidas de curto prazo. Em resposta a um aumento da incerteza da política econômica, as empresas tendem a depender menos da dívida de longo prazo e, em vez disso, optam por aumentar o uso da dívida de curto prazo. Esses resultados se mantêm consistentes em diferentes especificações propostas. Brasil Bolsa B3. B . (B3) afetadas 16 201 2019 trimestral endógena país generalized GMMsys GMM sys GMM-sys estimativas negócios relevante externos disso propostas (B3 1 20 (B 2

Abstract This article aimed to investigate the relationship between economic policy uncertainty (EPU) and long- and short-term debt of Brazilian firms traded on the Brasil, Bolsa, Balcão (B3) stock exchange. The discrepancy in previous results raises questions about the current understanding of the relationship between debt and EPU. Separate analyses of long- and short-term debt provide different insights into how corporate decisions are affected. This discrepancy challenges our existing understanding of the complex dynamics between debt and EPU. The research sample consists of 163 Brazilian firms listed on the B3 between 2010 and 2019 on a quarterly basis. The baseline models considered long- and short-term debt as endogenous, taking into account firm and country characteristics. We employed a two-stage system generalized method of moments (GMM-sys) panel approach to deal with potential endogeneity in the estimates. As the debt market plays a crucial role in corporate valuation and performance, it is increasingly important to study the dynamics of long- and short-term corporate debt amidst the challenges triggered by the spread of EPU in the business environment. Clarifying how both long- and short-term debt perform under such pressure is particularly relevant since it reinforces already observed and potential implications for corporate adaptability in the use of external funds. The impact of this study lies in revealing the coexistence of firms’ cautious decisions in seeking representative funds and the conservative position for corporate investments regarding uncertainties that surround economic policy. The findings suggest that higher levels of EPU are associated with a decrease in the use of long-term debt and an increase in short-term debt. In response to increased EPU, companies tend to rely less on long-term debt and instead opt for increased use of short-term debt. These results hold consistently across different proposed specifications. (EPU long shortterm short term Brasil Bolsa B (B3 exchange affected 16 201 basis endogenous characteristics twostage two stage GMMsys GMM sys (GMM-sys estimates performance environment longterm specifications (B 1 20 2

Resumo O estudo visa identificar e analisar fatores associados à insegurança alimentar (IA), as tendências e a distribuição espacial para estratos geográficos. Investigou-se a hipótese de piora do desfecho de IA grave nos domicílios, medido pela Escala Brasileira de Insegurança Alimentar (EBIA), como efeito da crise e/ou da política de austeridade. O artigo envolve estudos com desenho transversal para análises seccionais e ecológico misto de tendências espaço-temporais, a partir de quatro inquéritos nacionais do IBGE. Adotou-se procedimento de calibração dos pesos segundo distribuição por sexo e faixa etária e métodos de estimação e modelagem que incorporam efeitos do desenho amostral. A regressão de Poisson com estimação robusta de variância foi empregada para estimar razões de prevalências de IA grave em nível etiológico. Para o nível ecológico, empregou-se duas abordagens de modelagem multinível para medidas repetidas de estratos: regressão múltipla log-log para associações; e modelagem de splines para estimação de tendências. Os achados apontam impactos da austeridade adotada, com mudanças de tendências no Programa Bolsa Família e reflexos sobre o aumento da IA grave. Projeta-se o aumento da IA e afastamento do alcance do objetivo nº 2 dos ODS em 2030 pelo Brasil, a despeito do sucesso obtido em 2014 para o ODM nº 1. IA, , (IA) geográficos Investigouse Investigou se domicílios EBIA, EBIA (EBIA) eou ou espaçotemporais, espaçotemporais espaço temporais, temporais espaço-temporais IBGE Adotouse Adotou amostral etiológico empregouse empregou loglog log associações adotada Projetase Projeta 203 Brasil 201 1 (IA (EBIA 20

Abstract This study aims to identify and analyse factors associated with food insecurity (FI), trends and spatial distributions for geographical strata. The hypothesis of worsening of the outcome of severe FI, measured by the Brazilian Food Insecurity Scale (EBIA) in households, as an effect of the crisis and/or the austerity policy, was investigated. The article involves studies with cross-sectional design and mixed ecological for spatio-temporal trends, based on 4 national IBGE surveys. A weight calibration procedure to match population distribution by gender and age group was adopted, as well as estimation and modelling methods that incorporate effects of the sample design. Poisson regression with robust estimation of variance was used to estimate prevalence ratios of severe FI at the etiological level. For the ecological level, two multilevel modelling approaches were employed for repeated measurements of strata: multiple log-log regression for associations; and modelling of splines for trend estimation. The findings point to impacts of the austerity policy adopted, with changes in trends in the Programa Bolsa Família - PBF (Family Benefit Programme - FBP) and on the increase in severe FI. It is projected that there will be an increase in FI and a shortfall in relation to achievement of the SDG no. 2 in 2030 by Brazil, despite the success obtained in 2014 for MDG no. 1. , (FI) strata EBIA (EBIA households andor or investigated crosssectional cross sectional spatiotemporal spatio temporal surveys adopted level loglog log associations Family FBP no 203 Brazil 201 1 (FI 20

Resumen Este estudio tiene como objetivo identificar y analizar factores asociados a la inseguridad alimentaria (IA), tendencias y distribución espacial por estratos geográficos. Se investigó la hipótesis de un deterioro del resultado de IA grave en los hogares, medido por la Escala Brasileña de Inseguridad Alimentaria (EBIA), como efecto de la crisis o de la política de austeridad. El artículo involucra estudios con diseño transversal para análisis ecológicos transversales y mixtos de tendencias espacio-temporales, basados en cuatro encuestas nacionales del IBGE. Se adoptó un procedimiento de calibración de los pesos según distribución por sexo y grupo de edad y métodos de estimación y modelación que incorporan efectos del diseño muestral. Se utilizó la regresión de Poisson con estimación robusta de la varianza para estimar los índices de prevalencia de IA grave a nivel etiológico. Para el nivel ecológico, se utilizaron dos enfoques de modelado multinivel para mediciones repetidas de estratos: regresión múltiple log-log para asociaciones y modelado Splines para estimación de tendencias. Los hallazgos apuntan a los impactos de la austeridad adoptada, con cambios en las tendencias del Programa Bolsa Familia e impactos en el aumento de la IA severa. Se proyecta que Brasil aumentará la IA y se alejará de alcanzar el objetivo N°2 de los ODS en 2030, a pesar del éxito alcanzado en 2014 para el ODM nº1. IA, , (IA) geográficos hogares EBIA, EBIA (EBIA) espaciotemporales, espaciotemporales espacio temporales, temporales espacio-temporales IBGE muestral etiológico ecológico loglog log adoptada severa N2 N 2 N° 2030 201 nº1 nº (IA (EBIA 203 20

RESUMO Esse estudo objetivou investigar os efeitos da manipulação da altura da rede em jogos reduzidos de 4 x 4 no desempenho tático-técnico de atletas profissionais femininas de voleibol. Participaram oito atletas femininas profissionais, que jogaram 4 x 4 em três alturas de rede: 2,15 m, 2,24 m e 2,33 m. As ações técnico-táticas (Desempenho Específico por Ação, Desempenho Específico por Componente e Desempenho Geral) foram analisadas através do IAD-VB. Os resultados indicaram que a menor altura favoreceu as ações do complexo 0 (p=0.034; V=0.329), enquanto a maior altura da rede favoreceu o levantamento (p=0.001; V=0.449), ataque (p=0.038; V=0.325), e estruturação das ações defensivas (p<0.001; V=0.731). Adicionalmente, a altura da rede foi associada ao componente de tomada de decisão (p=0.011; V=0.368), sugerindo que esta manipulação específica pode afetar a complexidade do processo de tomada de decisão no cenário de jogo. táticotécnico tático técnico voleibol 215 2 15 2,1 224 24 2,2 233 33 2,3 técnicotáticas táticas Ação Geral IADVB. IADVB IAD VB. VB IAD-VB p=0.034 p0034 p 034 (p=0.034 V=0.329, V0329 V V=0.329 , 329 V=0.329) p=0.001 p0001 001 (p=0.001 V=0.449, V0449 V=0.449 449 V=0.449) p=0.038 p0038 038 (p=0.038 V=0.325, V0325 V=0.325 325 V=0.325) p<0.001 (p<0.001 V=0.731. V0731 V=0.731 . 731 V=0.731) Adicionalmente p=0.011 p0011 011 (p=0.011 V=0.368, V0368 V=0.368 368 V=0.368) jogo 21 1 2, 22 23 3 p=0.03 p003 03 (p=0.03 V032 V=0.32 32 p=0.00 p000 00 (p=0.00 V044 V=0.44 44 p<0.00 (p<0.00 V073 V=0.73 73 p=0.01 p001 01 (p=0.01 V036 V=0.36 36 p=0.0 p00 (p=0.0 V03 V=0.3 V04 V=0.4 p<0.0 (p<0.0 V07 V=0.7 7 p=0. p0 (p=0. V0 V=0. p<0. (p<0. p=0 (p=0 V=0 p<0 (p<0 p= (p= V= p< (p< (p

ABSTRACT This study investigated the effects of manipulating the net height in 4 vs. 4 small-sided games on the tactical-technical performance of professional female volleyball athletes. Eight professional female athletes participated in this study, playing 4 vs. 4 small-sided games at three net heights: 2.15 m, 2.24 m, and 2.33 m. The technical-tactical actions (Specific Performance per Action, Specific Performance per Component, and General Performance) were analyzed through the IAD-VB. Results indicated that the lower net height favored the complex 0 actions (p=0.034; V=0.329), while the higher net height favored setting (p=0.001; V=0.449), attack (p=0.038; V=0.325), and defense (p<0.001; V=0.731) action structuring. Additionally, the net height was associated with the decision-making component (p=0.011; V=0.368), suggesting that this specific manipulation may affect the complexity of the decision-making process in the game setting. vs smallsided small sided tacticaltechnical tactical technical heights 215 2 15 2.1 m 224 24 2.2 233 33 2.3 technicaltactical Action Component IADVB. IADVB IAD VB. VB IAD-VB p=0.034 p0034 p 034 (p=0.034 V=0.329, V0329 V V=0.329 , 329 V=0.329) p=0.001 p0001 001 (p=0.001 V=0.449, V0449 V=0.449 449 V=0.449) p=0.038 p0038 038 (p=0.038 V=0.325, V0325 V=0.325 325 V=0.325) p<0.001 (p<0.001 V=0.731 V0731 731 structuring Additionally decisionmaking decision making p=0.011 p0011 011 (p=0.011 V=0.368, V0368 V=0.368 368 V=0.368) 21 1 2. 22 23 3 p=0.03 p003 03 (p=0.03 V032 V=0.32 32 p=0.00 p000 00 (p=0.00 V044 V=0.44 44 p<0.00 (p<0.00 V=0.73 V073 73 p=0.01 p001 01 (p=0.01 V036 V=0.36 36 p=0.0 p00 (p=0.0 V03 V=0.3 V04 V=0.4 p<0.0 (p<0.0 V=0.7 V07 7 p=0. p0 (p=0. V0 V=0. p<0. (p<0. p=0 (p=0 V=0 p<0 (p<0 p= (p= V= p< (p< (p

RESUMEN Este studio tuvo como objetivo investigar los efectos de la manipulación de la altura de la red em juegos reducidos de 4 vs. 4 sobre el rendimiento táctico-técnico de atletas profesionales de voleibol femenino. Participaron ocho atletas femininas professionais, que jugaron 4 vs. 4 en tres alturas de red: 2,15 m, 2,24 m y 2,33 m. Las acciones técnico-tácticas (Rendimiento Especifico por Acción, Rendimiento Especifico por Componente y Rendimiento General) fueron analizadas mediante el IAD-VB. Los resultados indicaron que la menor altura favoreció las acciones del complejo 0 (p=0.034; V=0.329), mientras que la mayor altura de la red favoreció la distribuición (p=0.001; V=0.449), ataque (p=0.038; V=0.325) y la estructuración defensiva (p<0.001; V=0.731). Además, la altura de la red se asoció con el componente de toma de decisión (p=0.011; V=0.368), lo que sugiere que esta manipulación específica puede afectar la complejidad del proceso de toma de decisión en el scenario del juego. vs tácticotécnico táctico técnico femenino professionais 215 2 15 2,1 224 24 2,2 233 33 2,3 técnicotácticas tácticas Acción General IADVB. IADVB IAD VB. VB IAD-VB p=0.034 p0034 p 034 (p=0.034 V=0.329, V0329 V V=0.329 , 329 V=0.329) p=0.001 p0001 001 (p=0.001 V=0.449, V0449 V=0.449 449 V=0.449) p=0.038 p0038 038 (p=0.038 V=0.325 V0325 325 p<0.001 (p<0.001 V=0.731. V0731 V=0.731 . 731 V=0.731) Además p=0.011 p0011 011 (p=0.011 V=0.368, V0368 V=0.368 368 V=0.368) juego 21 1 2, 22 23 3 p=0.03 p003 03 (p=0.03 V032 V=0.32 32 p=0.00 p000 00 (p=0.00 V044 V=0.44 44 p<0.00 (p<0.00 V073 V=0.73 73 p=0.01 p001 01 (p=0.01 V036 V=0.36 36 p=0.0 p00 (p=0.0 V03 V=0.3 V04 V=0.4 p<0.0 (p<0.0 V07 V=0.7 7 p=0. p0 (p=0. V0 V=0. p<0. (p<0. p=0 (p=0 V=0 p<0 (p<0 p= (p= V= p< (p< (p

ABSTRACT Objective: MicroRNAs are small non-coding RNAs that are abundantly expressed in various biofluids, making them promising candidates for cancer biomarkers. This review aims to present current evidence on the use of miRNA as biomarkers for the non-invasive diagnosis of bladder cancer. Methods: A systematic literature review, using the Medline database, was performed in July 2022 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. All articles were required to satisfy the risk-of-bias assessment using the Joanna Briggs Institute Critical Assessment Tools. Data were collected based on miRNA expression, sample type, expression profiles, and accuracy. Results: The initial search retrieved 437 studies, 21 of which were included in the final analysis. Most studies on miRNA expression in human fluids used urine samples for analysis. Conclusion: There is a trend to cluster the expressed miRNAs to build diagnostic panels or use them in association with other diagnostic methods to achieve reasonable accuracy. Prospero database registration: (https://www.crd.york.ac.uk/prospero/) under ID CRD42022351686. Objective noncoding non coding biofluids noninvasive invasive Methods 202 MetaAnalyses Meta Analyses guidelines riskofbias risk bias Tools type profiles accuracy Results 43 2 analysis Conclusion registration https//www.crd.york.ac.uk/prospero/ httpswwwcrdyorkacukprospero https //www.crd.york.ac.uk/prospero/ www crd york ac uk prospero (https://www.crd.york.ac.uk/prospero/ CRD42022351686 CRD 20 4 https//www.crd.york.ac.uk/prospero wwwcrdyorkacukprospero //www.crd.york.ac.uk/prospero (https://www.crd.york.ac.uk/prospero CRD4202235168 CRD420223516 CRD42022351 CRD4202235 CRD420223 CRD42022 CRD4202 CRD420 CRD42 CRD4

ABSTRACT Objective: To assess the relationship between celiac disease and the prevalence of dental caries in children and adolescents and also evaluate if dental enamel defects in celiac children predispose to dental caries. Material and Methods: Searches were performed in the following databases: PubMed, Scopus, Cochrane Library, Latin American and Caribbean Literature on Health Sciences, and OpenGrey. The risk of bias was assessed using the Newcastle-Ottawa Scale. DMFT/dmft and DMFS/dmfs data of observational studies that compared the prevalence of caries between children and adolescents with celiac disease and healthy individuals. Meta-analysis was performed using a random effects model. Heterogeneity between studies was estimated using Cochran’s Q test, and inconsistency was measured using I2 statistics. Results: Of the 121 studies retrieved, 17 were selected, and 12 were included in the meta-analysis. The prevalence of caries in the primary dentition (dmft) did not differ between celiac patients and controls [SMD = -0.35; 95% CI (-0.83; 0.13); p = 0,15; I2 = 89%]. There was also no difference in the prevalence of caries in permanent teeth (DMFT) between groups [SMD = -0.44; 95% CI (-1.02; 0.14); p = 0.14; I2 = 95%]. Conclusion: Celiac disease is not a determinant factor in the development of dental caries in children and adolescents compared to the control group. Objective Methods databases PubMed Scopus Library Sciences OpenGrey NewcastleOttawa Newcastle Ottawa Scale DMFTdmft DMFT dmft DMFSdmfs DMFS dmfs individuals Metaanalysis Meta analysis model Cochrans Cochran s test I statistics Results retrieved 1 selected metaanalysis. metaanalysis meta analysis. meta-analysis (dmft SMD 0.35 035 0 35 -0.35 95 0.83 083 83 (-0.83 0.13 013 13 0.13) 0,15 015 15 89%. 89 89% . 89%] (DMFT 0.44 044 44 -0.44 1.02 102 02 (-1.02 0.14 014 14 0.14) 95%. 95%] Conclusion group 0.3 03 3 -0.3 9 0.8 08 8 (-0.8 0.1 01 0,1 0.4 04 4 -0.4 1.0 10 (-1.0 0. -0. (-0. 0, 1. (-1. -0 (-0 (-1 - (- (

ABSTRACT Objective: To evaluate the impact of endodontic treatment with photobiomodulation on oral health-related quality of life (HRQoL). Material and Methods: Seventy participants with single-rooted teeth and a diagnosis of asymptomatic apical periodontitis were selected and randomized into two groups: control group (CG, n = 35), root canal treatment without additional treatment, and experimental group (EG, n = 35), root canal treatment associated with antimicrobial photodynamic therapy and low-level laser therapy. OHRQoL was assessed using the Oral Health Impact Profile Questionnaire (OHIP-14) at baseline and 7 and 30 days after treatment. Data were subjected to Wilcoxon, Mann-Whitney tests, and linear regression using the generalized estimating equation model, using the Statistical Package for Social Science software with a significance level of 5%. Results: No statistically significant differences were found between groups regarding sociodemographic and clinical characteristics (p>0.05). There was also no difference in the OHRQoL between the CG and EG (p>0.05). However, there was a statistical difference in OHIP-14 scores between baseline and the 7- and 30-day follow-up intervals in both groups for all domains (p<0.05). Conclusion: Root canal treatment, with or without photobiomodulation, significantly improved the OHRQoL of participants after 7 and 30 days of treatment. Objective healthrelated health related HRQoL. HRQoL . (HRQoL) Methods singlerooted single rooted CG, (CG 35, 35 , 35) EG, (EG lowlevel low OHIP14 OHIP 14 (OHIP-14 3 Wilcoxon MannWhitney Mann Whitney tests model 5 5% Results p>0.05. p005 p p>0.05 0 05 (p>0.05) However OHIP-1 30day day followup follow up p<0.05. p<0.05 (p<0.05) Conclusion (HRQoL OHIP1 1 (OHIP-1 p00 p>0.0 (p>0.05 OHIP- p<0.0 (p<0.05 (OHIP- p0 p>0. (p>0.0 p<0. (p<0.0 (OHIP p>0 (p>0. p<0 (p<0. p> (p>0 p< (p<0 (p> (p< (p