Resumo Nosso objetivo foi analisar a associação entre a duração do trabalho remoto e o diagnóstico positivo da COVID-19 entre pessoas ocupadas no Brasil. Foram utilizados dados da PNAD COVID19 (2020). As variáveis sobre a situação do trabalho descritas foram: afastamento do trabalho em função do distanciamento físico, segmento de trabalho (setor de trabalho e formalidade: privado formal/informal, militar, servidor público estatutário, setor público CLT/informal, empregador, conta-própria/trabalhador não remunerado) e duração do trabalho remoto (sem trabalho remoto, 1-2 meses, 3-4 meses, 5-7 meses). Associação entre duração do trabalho remoto (exposição) e diagnóstico positivo para COVID-19 (desfecho) foi estimada por regressão de Cox, com ajuste para variáveis sociodemográficas e segmento de trabalho. O diagnóstico positivo da COVID-19 aumentou de 2,1% para 4,8% entre julho e novembro, e a frequência de trabalho remoto reduziu de 11,6% para 9,5% entre maio e novembro. O risco de diagnóstico positivo da COVID-19 foi menor para pessoas que trabalharam remotamente por 3-4 meses (RR=0,79; IC95%=0,67;0,92) e 5 meses (RR=0,57; IC95%=0,48;0,67) comparadas àquelas que não trabalharam remotamente. Houve discreta redução do percentual de trabalhadores em trabalho remoto e sua maior extensão reduziu o risco de diagnóstico positivo para COVID-19.

Abstract The scope of this work was to assess the association between the duration of remote work and a positive diagnosis of COVID-19 among individuals employed in Brazil. Data from the PNAD COVID19 (2020) survey were consulted. The variables in the work situation described included: absence from work due to physical distancing, work segment (work sector and formality: formal or informal private, military, statutory civil servant, CLT public sector, informal public sector, employer, self-employed/unpaid worker) and duration of remote work (no remote work for 1-2 months, 3-4 months, 5-7 months, respectively). The association between duration of remote work (exposure) and positive diagnosis for COVID-19 (outcome) was estimated by Cox regression, with adjustment for sociodemographic variables and work segment. The positive diagnosis of COVID-19 increased from 2.1% to 4.8% between July and November, and the frequency of remote work decreased from 11.6% to 9.5% between May and November. The risk of a positive diagnosis of COVID-19 was lower for people working remotely for 3-4 months, (HR=0.79; CI95%=0.67;0.92) and 5-7 months (HR=0.57; CI95%=0.48;0.67) compared to those who did not work remotely. There was a slight decrease in the percentage of remote work employees, and a longer duration reduced the risk of a positive diagnosis for COVID-19.

Abstract The scope of this work was to assess the association between the duration of remote work and a positive diagnosis of COVID-19 among individuals employed in Brazil. Data from the PNAD COVID19 (2020) survey were consulted. The variables in the work situation described included: absence from work due to physical distancing, work segment (work sector and formality: formal or informal private, military, statutory civil servant, CLT public sector, informal public sector, employer, self-employed/unpaid worker) and duration of remote work (no remote work for 1-2 months, 3-4 months, 5-7 months, respectively). The association between duration of remote work (exposure) and positive diagnosis for COVID-19 (outcome) was estimated by Cox regression, with adjustment for sociodemographic variables and work segment. The positive diagnosis of COVID-19 increased from 2.1% to 4.8% between July and November, and the frequency of remote work decreased from 11.6% to 9.5% between May and November. The risk of a positive diagnosis of COVID-19 was lower for people working remotely for 3-4 months, (HR=0.79; CI95%=0.67;0.92) and 5-7 months (HR=0.57; CI95%=0.48;0.67) compared to those who did not work remotely. There was a slight decrease in the percentage of remote work employees, and a longer duration reduced the risk of a positive diagnosis for COVID-19.

Resumo Nosso objetivo foi analisar a associação entre a duração do trabalho remoto e o diagnóstico positivo da COVID-19 entre pessoas ocupadas no Brasil. Foram utilizados dados da PNAD COVID19 (2020). As variáveis sobre a situação do trabalho descritas foram: afastamento do trabalho em função do distanciamento físico, segmento de trabalho (setor de trabalho e formalidade: privado formal/informal, militar, servidor público estatutário, setor público CLT/informal, empregador, conta-própria/trabalhador não remunerado) e duração do trabalho remoto (sem trabalho remoto, 1-2 meses, 3-4 meses, 5-7 meses). Associação entre duração do trabalho remoto (exposição) e diagnóstico positivo para COVID-19 (desfecho) foi estimada por regressão de Cox, com ajuste para variáveis sociodemográficas e segmento de trabalho. O diagnóstico positivo da COVID-19 aumentou de 2,1% para 4,8% entre julho e novembro, e a frequência de trabalho remoto reduziu de 11,6% para 9,5% entre maio e novembro. O risco de diagnóstico positivo da COVID-19 foi menor para pessoas que trabalharam remotamente por 3-4 meses (RR=0,79; IC95%=0,67;0,92) e 5 meses (RR=0,57; IC95%=0,48;0,67) comparadas àquelas que não trabalharam remotamente. Houve discreta redução do percentual de trabalhadores em trabalho remoto e sua maior extensão reduziu o risco de diagnóstico positivo para COVID-19.

Abstract Objective: To describe the trend of participation in group and individual support by human milk banks (HMBs) provided between 2010 and 2019 in Brazil. Methods: Ecological study with data from participation in group and individual support provided by the HMBs between 2010 and 2019, available in the production report of the Brazilian Network of Human Milk Banks. The number of participation in group and individual support was expressed for Brazil and for Brazilian macroregions in absolute numbers. Trend analysis was performed from the analysis of index numbers, considering the year 2010 as a reference. It was calculated the ratio of the number of participation in group and individual support by HMBs for each macroregion and year. Results: There was an increase of 42% in participation in group support (300,595 in 2010 vs 425,570 in 2019) and an increase of 69% in individual support (1,157,038 in 2010 vs 1,962,162 in 2019). The North and Northeast macroregions had the highest growth rates in the provision of these services (122 and 131%, respectively), above the national growth rate in the study period. In contrast, the Midwest region showed a downward trend throughout this period, for both types of support. However, in the Midwest, there was a higher ratio of participation in groups by HMBs between 2010 and 2016 and for individual support by HMBs between 2010 and 2012. Conclusion: Individual and group support provided by the HMB as a strategy to support breastfeeding increased considerably in Brazil during the study period, especially in the North and Northeast regions.

RESUMO Introdução: O surgimento de lesão renal aguda (LRA) em pacientes com síndrome nefrótica (SN) requer diagnóstico imediato e diferenciação entre necrose tubular aguda (NTA) e glomerulonefrite proliferativa. Avaliamos o uso potencial de testes de biomarcadores urinários comerciais no diagnóstico de LRA em pacientes com SN. Métodos: Uma estimativa transversal das concentrações urinárias de KIM-1 e NGAL foi realizada em 40 pacientes com SN: 9 com glomerulopatia proliferativa, sendo 4 com LRA e 31 sem glomerulopatia proliferativa, sendo 15 com LRA. A LRA foi definida usando os critérios da KDIGO. Resultados: A média de idade foi de 35 ± 16 anos. Os principais diagnósticos foram glomeruloesclerose segmentar e focal (10, 25%), glomerulopatia membranosa (10, 25%), doença por lesão mínima (7, 18%), nefrite lúpica (6, 15%) e glomerulonefrite proliferativa (3, 8 %). Os pacientes com NTA apresentaram níveis mais elevados de KIM-1 urinário (P = 0,0157) e NGAL (P = 0,023) do que pacientes sem NTA. As concentrações urinárias de KIM-1 (P = 0,009) e NGAL (P = 0,002) foram maiores em pacientes com LRA do que em pacientes sem LRA. Os níveis urinários de NGAL e KIM-1 foram significativamente maiores em pacientes com NTA sem glomerulonefrite proliferativa do que em pacientes com glomerulonefrite proliferativa (P = 0,003 e P = 0,024, respectivamente). Conclusões: As estimativas de lipocalina associada a gelatinase de neutrófilos (NGAL) e molécula de lesão renal 1 (KIM-1) se correlacionaram com sinais histológicos de NTA, e foram capazes de discriminar pacientes com LRA mesmo em condições de SN. Além disso, os níveis urinários de NGAL e KIM-1 podem ser úteis no diagnóstico diferencial de necrose tubular aguda e glomerulonefrite exsudativa em pacientes com síndrome nefrótica.

ABSTRACT Introduction: Emergence of acute kidney injury (AKI) in patients with nephrotic syndrome (NS) requires prompt diagnosis and differentiation between acute tubular necrosis (ATN) and proliferative glomerulonephritis. We studied the potential use of commercial urinary biomarkers' tests in the diagnosis of AKI in patients with NS. Methods: A cross sectional estimate of urinary concentrations of KIM-1 and NGAL was performed in 40 patients with NS: 9 with proliferative glomerulopathy, being 4 with AKI and 31 without proliferative glomerulopathy, being 15 with AKI. AKI was defined using the KDIGO criteria. Results: The mean age was 35 ± 16 years. The main diagnoses were focal and segmental glomerulosclerosis (10, 25%), membranous glomerulopathy (10, 25%), minimal change disease (7, 18%), lupus nephritis (6, 15%), and proliferative glomerulonephritis (3, 8%). Patients with ATN had higher levels of urinary KIM-1 (P = 0.0157) and NGAL (P = 0.023) than patients without ATN. The urinary concentrations of KIM-1 (P= 0.009) and NGAL (P= 0.002) were higher in patients with AKI than in patients without AKI. Urinary NGAL and KIM-1 levels were significantly higher in patients with ATN without proliferative glomerulonephritis than in patients with proliferative glomerulonephritis (P = 0.003 and P=0.024, respectively). Conclusions: Neutrophil gelatinase associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) estimates correlated with histological signs of ATN and were able to discriminate patients with AKI even in conditions of NS. Furthermore, urinary levels of NGAL and KIM-1 may be useful in the differential diagnosis of acute tubular necrosis and exudative glomerulonephritis in patients with nephrotic syndrome.

Objetivo: analisar os fatores associados ao risco de suicídio em estudantes de pós-graduação. Método: estudo transversal analítico, desenvolvido com 565 pós-graduandos stricto sensu de agosto a setembro de 2019. A coleta de dados ocorreu por meio de um instrumento validado contendo variáveis demográficas, socioeconômicas, de saúde e acadêmicas; do módulo C do Mini International Neuropsychiatric Interview (MINI), versão 5.0; do questionário CAGE (Cut down, Annoyed by criticism, Guilty e Eye-opener) e Escala de Depressão, Ansiedade e Estresse (DASS-21). Realizou-se análise estatística descritiva e múltipla com modelo de regressão de Poisson, nível de significância de 5%. Resultados: prevalência de 40,18% de risco de suicídio atual. Associaram-se com risco de suicídio atual as variáveis idade >30 anos (p=0,029), ausência de prática de fé (p=0,015), sintomas de depressão (p<0,001) ansiedade (p=0,018), uso de psicofármacos durante o curso (p<0,001), não ter um trabalho acadêmico significativo e inspirador (p=0,013), não ter uma boa relação com colegas da pós-graduação (p=0,033), ter relacionamento familiar prejudicado pelas demandas da pós-graduação (p=0,036) e preocupação com a situação financeira (p=0,048). Conclusão: identificou-se alta prevalência de risco de suicídio atual entre pós-graduandos e associação significativa deste risco com variáveis demográficas, socioeconômicas, acadêmicas e de saúde.

Objective: to analyze factors associated to suicide risk in postgraduate students. Method: a cross-sectional analytical study, developed with 565 stricto sensu postgraduate students from August to September 2019. Data collection took place using a validated instrument containing demographic, socioeconomic, health and academic variables; as well as variables of Module C of the Mini International Neuropsychiatric Interview (MINI), version 5.0; of the CAGE (Cut down, Annoyed by criticism, Guilty and Eye-opener) questionnaire; and the Depression, Anxiety and Stress Scale (DASS-21). Descriptive and multiple statistical analysis was performed using the Poisson regression model, with a significance level of 5%. Results: 40.8% prevalence of current suicide risk. The following variables were associated to current suicide risk: age > 30 years old (p=0.029), absence of faith (p=0.015), depression (p<0.001) and anxiety (p=0.018) symptoms, use of psychotropic drugs during the course (p<0.001), not having a meaningful and inspiring academic work (p=0.013), not having a good relationship with colleagues from the postgraduate school (p=0.033), having family relationship impaired by the demands of the postgraduate school (p=0.036) and concern about the financial situation (p=0.048). Conclusion: a high prevalence of current suicide risk was identified among postgraduate students, as well as a significant association of this risk with demographic, socioeconomic, academic and health variables.

Objetivo: analizar los factores asociados al riesgo de suicidio en estudiantes de posgrado. Método: estudio analítico transversal, desarrollado con 565 estudiantes de posgrado stricto sensu de agosto a septiembre de 2019. La recolección de datos se realizó mediante un instrumento validado que contiene variables demográficas, socioeconómicas, de salud y académicas; Módulo C de la Mini International Neuropsychiatric Interview (MINI), versión 5.0; el cuestionario CAGE (Cut down, Annoyed by criticism, Guilty e Eye-opener) y la Escala de Depresión, Ansiedad y Estrés (DASS-21). El análisis estadístico descriptivo y múltiple se realizó mediante el modelo de regresión de Poisson, con un nivel de significancia del 5%. Resultados: prevalencia del 40,18% del riesgo actual de suicidio. Las siguientes variables se asociaron con el riesgo de suicidio actual: edad >30 años (p=0,029), falta de fe (p=0,015), síntomas de depresión (p<0,001) ansiedad (p=0,018), uso de psicofármacos durante el curso (p<0,001), no tener un trabajo académico significativo e inspirador (p=0,013), no tener una buena relación con los compañeros de posgrado (p=0,033), tener una relación familiar deteriorada por las exigencias del posgrado (p=0,036) y preocupación por la situación financiera (p=0,048). Conclusión: se identificó una alta prevalencia de riesgo actual de suicidio entre los estudiantes de posgrado y una asociación significativa de este riesgo con variables demográficas, socioeconómicas, académicas y de salud.

RESUMO Pavimento permeável é uma alternativa para o manejo das águas pluviais urbanas que permite a redução da precipitação efetiva através do processo de infiltração. O estudo avaliou a capacidade de infiltração de um pavimento permeável (PP) de blocos vazados de concreto no estacionamento da Universidade Federal de Pernambuco. A caracterização hidrodinâmica e a capacidade de infiltração foram analisadas em escala real, utilizando infiltrômetro de anel simples de 100 cm de diâmetro através do método Beerkan. Realizaram-se ensaios de infiltração em doze pontos do PP. Foi aplicado o algoritmo BEST na sua versão Best-Intercept e Best-Slope, para a estimativa dos parâmetros hidrodinâmicos da equação de van Genutchen e Brooks e Corey para as curvas de retenção e de condutividade hidráulica da superfície do pavimento permeável. Os valores da condutividade hidráulica saturada determinados pelo método BEST Intercept foram superiores aos obtidos pelo BEST Slope. Os valores da Sorvidade estimados pelo BEST Slope e Intercept foram semelhantes, sendo os valores do BEST Slope ligeiramente superiores. Observou-se moderada variabilidade da infiltração na superfície do PP, como também dentro do mesmo tipo de textura. O método Beerkan demonstrou ser adaptável para medir, em escala de campo, a infiltração tridimensional na camada de revestimento do pavimento permeável.

ABSTRACT Permeable pavement (PP) is an alternative for the management of urban rainwater that allows the reduction of effective precipitation through the infiltration process. In this study was evaluated the infiltration capacity of a PP of hollow concrete blocks in a parking lot of the Federal University of Pernambuco. The hydraulic characterization and the infiltration capacity were analyzed in real scale, using a simple ring infiltrometer of 100 cm in diameter through the Beerkan method. Infiltration tests were carried out at twelve points of the PP. The BEST algorithm was applied in it Best-Intercept and Best-Slope version, to estimate the hydraulic parameters of the van Genutchen and Brooks and Corey equations for the retention and hydraulic conductivity of the PP surface. The values of saturated hydraulic conductivity determined by the BEST Intercept method were higher than those obtained by BEST Slope. The sorptivity values estimated by BEST Slope and Intercept were similar, with BEST Slope values slightly higher. Moderate infiltration variability was observed on the PP surface, as well as within the same type of texture. The Beerkan method proved to be adaptable to measure, in field scale, the three-dimensional infiltration in the PP covering layer.

Abstract Squamous cell carcinoma of the oral cavity and oropharynx is the sixth most common type of cancer in the world. During tumorigenesis, gene promoter hypermethylation is considered an important mechanism of transcription silencing of tumor suppressor genes, such as DAPK, MGMT and RUNX3. These genes participate in signaling pathways related to apoptosis, DNA repair and proliferation whose loss of expression is possibly associated with cancer development and progression. In order to investigate associations between hypermethylation and clinicopathological and prognostic parameters, promoter methylation was evaluated in 72 HPV negative oral and oropharyngeal tumors using methylation-specific PCR. Hypermethylation frequencies found for DAPK, MGMT and RUNX3 were 38.88%, 19.44% and 1.38% respectively. Patients with MGMT hypermethylation had a better 2-year overall survival compared to patients without methylation. Being MGMT a repair gene for alkylating agents, it could be a biomarker of treatment response for patients who are candidates for cisplatin chemotherapy, predicting drug resistance. In view of the considerable levels of hypermethylation in cancer cells and, for MGMT, its prognostic relevance, DAPK and MGMT show potential as epigenetic markers, in a way that additional studies may test its viability and efficacy in clinical management.