Abstract Consumers are more demanding in relation to meat quality, developing new demands, such as increased shelf life and good sensory quality. The tenderness of the meat is one of the most important elements in the choice of the product, the modification in the intrinsic structure of the meat, for example, increase of the proteolysis and fragmentation of the myofibrils contribute to the improvement of the tenderness. However, it is necessary to develop technological strategies so that this ultrasound technology can be added to improve meat tenderness. Thus, the objective of this review was to know the main aspects of the use of ultrasound and acerola residue in meat tenderness. Overall, existing research demonstrates excellent prospects for this new redesign approach.

ABSTRACT Background: Chagas disease (CD) is caused by Trypanosoma cruzi and transmitted by triatomines. Historical information from the 20th century demonstrates T. cruzi records in the metropolitan region of Salvador (MRS), the third largest urban agglomeration in the Brazilian Northeast and the eighth largest in Brazil, an area with intense migratory activity from CD-endemic regions. Therefore, this study aimed to evaluate CD indicators (prevalence and mortality) in the MRS. Methods: A mixed ecological and descriptive study was conducted using secondary data. We analyzed data from 2008 to 2015: deaths due to CD, self-reported cases of CD, and blood donors that were non-negative for T. cruzi infection. Results: São Francisco do Conde was one of the municipalities with the highest mortality rates due to CD. The seroprevalence rates varied by year and municipality; those with the highest values were 2008: Vera Cruz, 2009: Mata de São João, 2010: Dias D'Ávila, 2011 and 2015: São Francisco do Conde, 2012: São Sebastião do Passé, and 2013 and 2014: Pojuca. Spatial correlations between the municipalities were not detected. Conclusions: We conclude that CD is present in the MRS. The indicators analyzed in the MRS are below-state-level data. Given the importance of indicator analysis for the surveillance and control of CD at the state and national levels, it is important to strengthen the surveillance program at the municipal level, including the regions classified as low risk for T. cruzi vector transmission.

ABSTRACT The aim of this study was to estimate inequality in physical activity and sports facilities at Brazilian public elementary schools, according to percent of self-reported black students. Our results showed that schools from urban or rural areas with a higher percentage of enrollments of self-reported black students (≥60%) presented fewer outdoor courtyards, sport court indoor and outdoor, playgrounds, dance studios, and materials for sports and recreation. These inequalities are a feature of racism, which is structural in Brazilian society and institutionalized in unfavorable conditions for engaging in physical activity and sports at public elementary schools where there is a higher number of black students.

RESUMEN Este estudio ecológico tuvo como objetivo estimar las desigualdades en las instalaciones para actividades físicas y deportivas (AF) en las escuelas públicas brasileñas de Educación Básica (n=70.276), según la proporción de matrículas de alumnos que se declararon negros. Los resultados mostraron que las escuelas urbanas y rurales con mayor proporción de matrículas de estudiantes negros (≥60%) tenían menos patio al aire libre, canchas interiores y exteriores, parques infantiles, estudios de danza y materiales para deportes y recreación. Esas desigualdades son rasgos del racismo, que es estructural en la sociedad brasileña y está institucionalizado al ofrecer condiciones desfavorables para la práctica de AF en las escuelas públicas que atienden a un mayor número de alumnos negros y pardos.

RESUMO O objetivo deste estudo ecológico foi estimar desigualdades nas instalações para atividades físicas e esportes (AF) nas escolas públicas de Educação Básica brasileiras (n=70.276), conforme a proporção de matrículas de estudantes autodeclarados negros. Os resultados mostraram que escolas urbanas e rurais com maior proporção de matrículas de estudantes negros (≥60%) apresentaram menos pátio descoberto, quadra coberta e descoberta, parque infantil, estúdio de dança e materiais para a prática desportiva e recreação. Essas desigualdades são traços do racismo, que é estruturante na sociedade brasileira e é institucionalizado na oferta de condições desfavoráveis ao engajamento em AF nas escolas públicas que atendem um maior número de alunos pretos e pardos.

Abstract The change in the lifestyle of modern consumers has increased the demand for meat products considered healthier, due tothe addition of animal fat in emulsified meat products, ingredient directly associated with the emergence of chronic diseases such as obesity and hypertension. In this sense, lipid reformulation processes aimed at replacing animal fat with other sources that are considered healthier, such as vegetable oils, appear as an innovative option for the production of meat products. However, it is necessary to develop technological strategies so that these oils can be added without causing undesirable technological and sensory effects to the final product. Thus, this study aimed to review the main aspects of the use of vegetable oils to replace animal fat in emulsified meat products. In general, existing research demonstrates excellent prospects for this new approach to redesign.

ABSTRACT A long-term experiment (2013 to 2017) of treated sewage effluent (TSE) levels via fertigation in a humid tropical region was installed in Jaboticabal, state of São Paulo, Southeast of Brazil, to evaluate the impact of TSE on soil fertility and the potential for salinization and heavy metal contamination of an Oxisol. The area was cultivated with Urochloa brizantha under the application of four TSE levels at the irrigation depth (0, 11, 60, and 100% TSE) during the four years of the experiment. The TSE chemical composition was monitored throughout the experimental period. The heavy metal levels and soil fertility were evaluated in the 0-0.10 and 0.10-0.20 m layers at the end of the four years of the experiment. Fertigation using TSE did not increase the concentration of potentially toxic elements (As, Cd, Cu, Hg, Mo, Ni, Pb, Se, and Zn) in the soil due to their low concentration in the effluent. A higher Na concentration was also observed at high TSE levels (60 and 100%). However, the sodium adsorption rate in the TSE was low, generating no potential for soil salinization and sodification. Fertigation with TSE levels increased soil fertility, increasing by more than 10% the P content and base saturation in the soil compared to control. According to the chemical attributes evaluated in the soil and effluent, this long-term study showed that TSE application via fertigation in humid tropical regions on clayey soils cultivated with forage grasses is recommended.

RESUMEN El propósito de este estudio fue evaluar las propiedades fisicoquímicas y los estudios de disolución de furosemida (FUR), hidroclorotiazida (HCTZ) y nifedipina (NIF), medicamentos de baja solubilidad en agua, en materias primas y formulaciones farmacéuticas. Técnicas de caracterización fisicoquímica y de superficie: microscopía electrónica de barrido (SEM), termogravimetría (TG), difracción de rayos X (XRD) y espectrometría infrarroja (IR), así como pruebas físicas y fisicoquímicas en tabletas y cápsulas que se aplicaron como información de apoyo sobre el control de calidad. Se desarrollaron y validaron métodos simples, rápidos y eficientes de UV-Vis para la determinación de muestras de FUR, HCTZ y NIF. SEM exhibió diferencias considerables en las estructuras morfológicas de cristal. Entre las drogas estudiadas, a excepción de la furosemida, más de un polimorfo estaba presente en las muestras. Los perfiles de liberación de fármacos fueron satisfactorios para todos los productos. Las tabletas FUR y HCTZ exhibieron perfiles de disolución similares, con una liberación muy rápida a las especialidades farmacéuticas (referencia, similares y genéricas). Para las tabletas de HCTZ, el medicamento similar (f2= 48,74) no es equivalente al medicamento de referencia. Las cápsulas NIF (de referencia y compuestas) mostraron una liberación >80% de la indicada en las etiquetas del producto, en 10 minutos. Los resultados obtenidos en este estudio sugieren que los parámetros de calidad y los perfiles de disolución del fármaco pueden haber sido influenciados por la morfología y el tamaño de los cristales, excipientes y procesos tecnológicos.

SUMMARY The purpose of this study was to evaluate physicochemical properties and dissolution studies of furosemide (FUR), hydrochlorothiazide (HCTZ) and nifedipine (NIF), low water solubility drugs, in raw materials and pharmaceutical formulations. Surface and physicochemical characterization techniques -scanning electronic microscopy (SEM), thermogravimetry (TG), X-ray diffraction (XRD) and infrared (IR) spectrometry- as well as physical and physicochemical tests on tablets and capsules were applied as supporting information on drug quality control. Simple, rapid, and efficient UV-Vis methods were developed and validated for the determination of FUR, HCTZ and NIF samples. SEM exhibited considerable differences in the crystal morphological structures. Among the drugs studied, except for furosemide, more than one polymorph was present in the samples. Drug release profiles were satisfactory for all products. FUR and HCTZ tablets exhibited similar dissolution profiles, with very rapid release to the pharmaceutical specialties (reference, similar and generic). For HCTZ tablets, the similar drug (f2= 48.74) is not equivalent to the reference drug. NIF capsules (reference and compounded) showed a release >80% of stated on product labels, in 10 minutes. The results obtained in this study suggest that the quality parameters and drug dissolution profiles may have been influenced by the morphology and size of the crystals, excipients, and technological processes.

RESUMO: A Leishmaniose visceral humana (LV) está em franca expansão e distribuída nas cinco regiões geográficas do Brasil, o Nordeste sendo a região em que há o maior número de casos registrados. O principal reservatório urbano do agente etiológico da LV é o cão doméstico e sabe-se que casos caninos antecedem o aparecimento de casos humanos. Uma das ações de controle da LV, preconizada pelo Ministério da Saúde, é a eutanásia dos cães soro reagentes. Em 2013, no município de Iguatama/MG, foi realizado o primeiro inquérito sorológico canino na cidade, sendo constatada uma prevalência de 8,3% de cães soro reagentes para Leishmania infantum. Dos animais com sorologia positiva para Leishmaniose visceral canina (LVC), neste inquérito, 84% foram eutanasiados e 16% foram a óbito em, no máximo, dois anos após o diagnóstico. Nenhuma outra medida de controle para LVC foi realizada no município. Os objetivos deste estudo foram determinar a prevalência atual de cães soro reagentes para LVC no município de Iguatama e observar o impacto das eutanásias de cães soro reagentes para LV como única medida de controle realizada neste município, considerado área enzoótica para a doença. Para isso, foi realizado um novo inquérito epidemiológico canino no município de Iguatama, seguindo as normas do Manual de Vigilância e Controle da Leishmaniose Visceral. Foram colhidas amostras sanguíneas de 270 cães que foram examinadas pelo teste imunocromatográfico DPP® e pelo ensaio imunoenzimático (ELISA). Os animais que apresentaram resultados inconclusivos tiveram novas amostras de sangue coletadas e analisadas. O único animal que apresentou resultado positivo no DPP® e indeterminado no ELISA, na primeira avaliação, soro converteu quatro meses depois, o que reforça a recomendação do Ministério da Saúde de reavaliar os cães que apresentam resultado inconclusivo para LVC. Do total das 270 amostras, 21 foram reagentes nos dois testes. Portanto, a prevalência de cães soro reagentes para LVC, em 2017, na área urbana do município de Iguatama foi igual a 7,8%. A infecção pela espécie Leishmania infantum foi confirmada através da técnica molecular de PCR-RFLP em 10 cães amostrados com sorologia positiva para LVC. A comparação entre a prevalência atual (depois das eutanásias) com a encontrada em 2013 (8,3%), não mostrou diferença significativa (p=0,764). Uma vez que a soro prevalência de LVC na área urbana do município de Iguatama ainda é alta, pode-se supor que a eutanásia dos cães soro reagentes para LVC, somada à ausência de monitoramento e de outras medidas de intervenção, não contribuiu para a diminuição da transmissão do parasito, e não foi suficiente para o controle de LVC no município de Iguatama, uma área considerada, até 2013, indene para LVC.

ABSTRACT: Human Visceral Leishmaniasis (VL) is expanding, and it is distributed in the five geographic regions of Brazil, with the Northeast being the region that presents the most significant number of registered cases. The main urban reservoir of the etiological agent of VL is the domestic dog, and it is known that canine cases precede human cases. One of the control actions of VL, recommended by the Ministry of Health, is performing the euthanasia of seropositive dogs. In 2013, in the municipality of Iguatama/MG, the first canine serological survey was carried out in the city, with a prevalence of 8.3% of seropositive dogs for Leishmania infantum. Of the seropositive animals for Canine Visceral Leishmaniasis (CVL) in this survey, 84% were euthanized, and 16% died within two years after diagnosis. No other control measures for CVL were taken in the municipality. The objectives of the present study were to determine the current prevalence of seropositive dogs for CVL in the municipality of Iguatama and to observe the impact of euthanasia of seropositive dogs to VL as the only control measure performed in this municipality, which is considered an enzootic area of the disease. For this, a new canine epidemiological survey was carried out in the municipality of Iguatama, following the guidelines of the Manual of Surveillance and Control of Visceral Leishmaniasis. Blood samples were collected from 270 dogs and tested by DPP® immunochromatographic test and by Enzyme-Linked Immunosorbent Assay (ELISA). The animals that presented inconclusive results had new blood samples collected and analyzed. The only animal that showed a positive result in DPP® and undetermined in the ELISA, in the first evaluation, became seropositive four months later, so this study reinforces the recommendation of the Ministry of Health to reassess dogs that present inconclusive results for CVL. From a total of 270 samples, 21 (7.8%) were reagents in both tests. Thus, the prevalence of seropositive dogs for CVL, in 2017, in the urban area of the municipality of Iguatama was 7.8%. The Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) molecular technique confirmed infection by L. infantum in the ten dogs sampled with CVL-positive serology. The comparison between the current prevalence (after euthanasia) with that found in 2013 (8.3%), there was no significant difference (p=0.764). The prevalence of CVL in the urban area of the municipality of Iguatama is still high, making it possible to presume that the euthanasia of seropositive dogs for CVL, and the absence of monitoring or other interventions measures, did not contribute to decrease the transmission of the parasite and was not sufficient for the control of CVL in the municipality of Iguatama, an area considered as non-endemic to CVL until 2013.

Resumo O impacto da chuva com a superfície de solos descobertos pode causar a desagregação de partículas e iniciar processos erosivos. Esta capacidade da chuva causar erosão em solos sem cobertura é chamada de erosividade e é expressa como R na Equação Universal de Perda de Solo. Áreas utilizadas com agricultura apresentam grau de susceptibilidade variável ao longo do ano, devido as oscilações nas taxas de exposição do solo e mudança da vegetação. Considerando que aproximadamente 30 milhões de hectares de Mato Grosso, no Brasil, são utilizados com agricultura, objetivou-se com o presente estudo estimar e mapear a variabilidade espacial e temporal da erosividade em seu território. Primeiramente, foram estimados valores de erosividade mensal (EI30) e anual (R) para 158 estações que, posteriormente, foram espacializados pelo método de krigagem. Observou-se que no estado de Mato Grosso predominam valores muito altos de R ao norte e altos e médio-altos ao sul. O valor médio de R é igual à 8835 MJ mm ha-1 h-1 ano-1, considerado alto. Noventa e um porcento do R se concentra no período entre os meses de outubro e abril, correspondente a estação chuvosa. Os maiores valores de R foram observados nas macrorregiões noroeste, norte, oeste e médio norte do estado de Mato Grosso.

Abstract The impact of rainfall on surfaces lacking vegetal cover can dissociate soil particles, thereby initiating the erosion process. This is known as rainfall erosivity and is expressed by the R factor in the Universal Soil Loss Equation. Agricultural areas often show seasonally erosion susceptibility throughout the year due to oscillations of the soil exposure rate and the vegetation change. Considering that approximately 30 million ha of the Mato Grosso State in Brazil is used for agriculture, this study aimed to predict and map the spatial and temporal variability of its territory. We evaluated the monthly (EI 30) and annual (R) erosivity for 158 rain gauge stations and spatialized the values of EI 30 and R by the Kriging method. It was observed that R values ranked as very high in the north, and high and medium-high in the south of Mato Grosso state. The mean value is 8835 MJ mm ha-1 h-1 year-1, considered high. Ninety-one percent of the annual erosivity was concentrated in the period between October and April, corresponding to the rainy season. The highest R factor values were found in the macro-regions of the northwest, north, west and medium-north of Mato Grosso State.

RESUMO. O alto consumo de água na agricultura irrigada e falta de fontes alternativas de água tornar a reutilização da água de esgoto uma opção altamente promissora nesta atividade. Este trabalho teve como objetivo avaliar o rendimento e a qualidade da forrageira Brachiaria brizantha cv. Marandu fertirrigada com águas residuais de efluente de esgoto tratado (EET) e fertilizante mineral, nos anos de 2013 e 2014, em Jaboticabal, Estado de São Paulo, Brasil. A lâmina homogênea da água foi aplicada por um sistema de irrigação por aspersão em linha tripla, mas sob aplicação gradual EET, usando os seguintes EET e água proporções: E5 = 1,0; E4 = 0,87; E3 = 0,6; E2 = 0,31, E1 = 0,11 e E0 = 0,0. O rendimento anual de biomassa aumentou com aplicação EET, variando 31,3-47,4 Mg ha-1 em 2013 e 25,7-56,9 Mg ha-1 em 2014, para E1 e E5, respectivamente. Houve sazonalidade na produção de forrageira, com os valores mais elevados no verão (35,9 a 44,7%) e primavera (35,7 a 38,4%) e as mais baixas durante a temporada de outono-inverno (19,6 a 25,7%). Apesar das altas doses de nitrogênio (1.132 kg ha-1), o rendimento máximo de forragem não foi alcançado, de modo que novos aumentos de nitrogênio ainda possam melhorar o rendimento. As baixas produtividades no outono-inverno foram compensadas pela melhor qualidade da forrageira em proteína bruta (PB) e fibra em detergente neutro (FDN).

ABSTRACT. The high consumption of water in irrigated agriculture and lack of alternative water sources make reusing sewage water a highly promising option for irrigation. This paper is aimed at evaluating Brachiaria brizantha cv. Marandu forage quality and yield when fertigated with treated sewage wastewater (TSW) and mineral fertilizer, in the 2013 and 2014 crop years in Jaboticabal, São Paulo State, Brazil. A homogeneous water depth was applied using a triple-line sprinkling irrigation system under a gradual TSW application, using the following TSW and water ratios: E5 = 1.0; E4 = 0.87; E3 = 0.6; E2 = 0.31, E1 = 0.11, and E0 = 0.0. Annual biomass yield increased with the TSW application, ranging from 31.3 to 47.4 Mg ha-1 in 2013 and from 25.7 to 56.9 Mg ha-1 in 2014, for E1 and E5, respectively. Forage yield had marked seasonality, with the highest values in summer (35.9 to 44.7%) and spring (35.7 to 38.4%) and the lowest ones during the fall-winter seasons (19.6 to 25.7%). Despite the high nitrogen rates (1,132 kg ha-1), maximum forage yield was not achieved, hence further nitrogen increments would still enhance yield. Forage improved quality has counterbalanced the low fall-winter yields in terms of crude protein (CP) and neutral detergent fibre (NDF).

É apresentada a experiência inicial com a cirurgia minimamente invasiva para o tratamento das afecções da valva aórtica, através da miniesternotomia em L invertido. No período de junho a novembro de 1997, 12 pacientes adultos foram submetidos a troca da valva aórtica. A técnica cirúrgica constitui-se na substituição da valva aórtica por prótese biológica, através de minitoracotomia, com esternotomia parcial do tipo L invertido, estendendo-se da fúrcula ao quarto espaço intercostal direito. O reduzido trauma cirúrgico proporcionou recuperação mais precoce. Em 1 (18,3%) caso, houve necessidade de conversão para esternotomia total por dificuldade de saída de CEC. A evolução tardia foi obtida em 11 (91,6%) casos, estando todos os pacientes assintomáticos.

We present our initial experience with minimally invasive surgery for the treatment of aortic valve diseases, through a minithoracotomy. From June to November of 1997, 12 patients underwent aortic valve replacement. The surgical technique utilized was ministernotomy from the notch to the fourth right intercostal space. There was no mortality, nor reoperation. There was necessity of complete sternotomy in one case because of difficult of leaving CPB. Late evolution was possible in 91.6% of the cases and they are all free of symptons.