Abstract Background: The European Society of Cardiology guidelines recommend an LDL-cholesterol (LDL-C) < 55 mg/dL for patients with established cardiovascular disease. While the Friedewald equation to estimate LDL-C is still widely used, the newer Martin-Hopkins equation has shown greater accuracy. Objectives: We aimed to assess: A) the proportion of patients reaching LDL-C goal and the therapies used in a tertiary center; B) the impact of using the Martin-Hopkins method instead of Friedewald’s on the proportion of controlled patients. Methods: A single-center cross-sectional study including consecutive post-myocardial infarction patients followed by 20 cardiologists in a tertiary hospital. Data was collected retrospectively from clinical appointments that took place after April 2022. For each patient, the LDL-C levels and attainment of goals were estimated from an ambulatory lipid profile using both Friedewald and Martin-Hopkins equations. A two-tailed p-value of < 0.05 was considered statistically significant for all tests. Results: Overall, 400 patients were included (aged 67 ± 13 years, 77% male). Using Friedewald’s equation, the median LDL-C under therapy was 64 (50-81) mg/dL, and 31% had LDL-C within goals. High-intensity statins were used in 64% of patients, 37% were on ezetimibe, and 0.5% were under PCSK9 inhibitors. Combination therapy of high-intensity statin + ezetimibe was used in 102 patients (26%). Applying the Martin-Hopkins method would reclassify a total of 31 patients (7.8%). Among those deemed controlled by Friedewald’s equation, 27 (21.6%) would have a Martin-Hopkins’ LDL-C above goals. Conclusions: Less than one-third of post-myocardial infarction patients had LDL-C within the goal. Applying the Martin-Hopkins equation would reclassify one-fifth of presumably controlled patients into the non-controlled group. Background LDLcholesterol LDL cholesterol LDLC C (LDL-C 5 mgdL mg dL disease MartinHopkins Martin Hopkins accuracy Objectives assess center B Friedewalds s Methods singlecenter single crosssectional cross sectional postmyocardial post myocardial 2 hospital 2022 patient equations twotailed two tailed pvalue p value 005 0 05 0.0 tests Results Overall 40 aged 6 1 years 77 male. male . male) 5081 50 81 (50-81 Highintensity High intensity 37 0.5 PCSK inhibitors highintensity high 10 26%. 26 26% (26%) 3 7.8%. 78 7.8% 7 8 (7.8%) 21.6% 216 21 (21.6% Conclusions onethird one third onefifth fifth noncontrolled non group 202 00 0. 4 508 (50-8 (26% 7.8 (7.8% 21.6 (21.6 (50- (26 7. (7.8 21. (21. (50 (2 (7. (21 (5 ( (7

Resumo Fundamento: As diretrizes da Sociedade Europeia de Cardiologia recomendam um nível de colesterol LDL (LDL-C) < 55 mg/dL para pacientes com doença cardiovascular estabelecida. Embora a fórmula de Friedewald ainda seja amplamente utilizada para estimar o LDL-C, a fórmula mais recente de Martin-Hopkins mostrou maior precisão. Objetivos: Nosso objetivo foi avaliar: A) a proporção de pacientes que atingiram a meta de LDL-C e as terapias utilizadas em um centro terciário; B) o impacto da utilização do método de Martin-Hopkins em vez do método de Friedewald na proporção de pacientes controlados. Métodos: Estudo transversal monocêntrico, incluindo pacientes consecutivos pós-infarto do miocárdio, acompanhados por 20 cardiologistas, em um hospital terciário. Os dados foram coletados retrospectivamente de consultas clínicas realizadas após abril de 2022. Para cada paciente, os níveis de LDL-C e o atingimento das metas foram estimados a partir de um perfil lipídico ambulatorial, utilizando as fórmulas de Friedewald e Martin-Hopkins. Um valor-p bicaudal < 0,05 foi considerado estatisticamente significativo para todos os testes. Resultados: Foram incluídos 400 pacientes (com 67 ± 13 anos, 77% do sexo masculino). Utilizando a fórmula de Friedewald, a mediana de LDL-C sob terapia foi de 64 (50-81) mg/dL, e 31% tinham LDL-C dentro da meta. Estatinas de alta intensidade foram usadas em 64% dos pacientes, 37% estavam em uso de ezetimiba e 0,5% estavam em uso de inibidores de PCSK9. A terapia combinada de estatina de alta intensidade + ezetimiba foi utilizada em 102 pacientes (26%). A aplicação do método de Martin-Hopkins reclassificaria um total de 31 pacientes (7,8%). Entre aqueles considerados controlados pela fórmula de Friedewald, 27 (21,6%) teriam LDL-C estimado por Martin-Hopkins acima da meta. Conclusões: Menos de um terço dos pacientes pós-infarto do miocárdio apresentaram LDL-C dentro da meta. A aplicação da fórmula de Martin-Hopkins reclassificaria um quinto dos pacientes presumivelmente controlados no grupo de pacientes não controlados. Fundamento LDLC C (LDL-C 5 mgdL mg dL estabelecida LDLC, C, MartinHopkins Martin Hopkins precisão Objetivos avaliar terciário B Métodos monocêntrico pósinfarto pós infarto 2 cardiologistas 2022 paciente ambulatorial MartinHopkins. Hopkins. valorp valor p 005 0 05 0,0 testes Resultados 40 6 1 anos 77 masculino. masculino . masculino) 5081 50 81 (50-81 37 0,5 PCSK9 PCSK 10 26%. 26 26% (26%) 3 7,8%. 78 7,8% 7 8 (7,8%) 21,6% 216 21 (21,6% Conclusões 202 00 0, 4 508 (50-8 (26% 7,8 (7,8% 21,6 (21,6 (50- (26 7, (7,8 21, (21, (50 (2 (7, (21 (5 ( (7

RESUMEN El objetivo de este estudio fue adaptar y validar la versión en español de la Escala de Aprendizaje Cooperativo (EAC) para estudiantes de educación superior portugueses y brasileños. Participaron en el estudio 493 estudiantes de educación superior entre 17 y 45 años de una universidad del norte de Portugal y 414 brasileños de entre 14 y 52 años de universidades de Brasil. Para la adaptación, el instrumento original, diseñado y validado para contextos españoles y para estudiantes del 3er ciclo de educación básica y de educación secundaria, pasó por varias fases: a) evaluación de expertos; b) estudio piloto; c) análisis factorial confirmatorio; y d) determinación de la validez convergente y divergente. Tanto la versión portuguesa como la brasileña del EAC presentan un buen modelo de ajuste e incluyen cinco factores con tres ítems cada uno: interdependencia positiva, habilidades sociales, interacción promotora, responsabilidad individual, y procesamiento grupal. (EAC 49 1 4 41 5 Brasil adaptación original er secundaria fases a expertos b piloto c confirmatorio d divergente uno positiva sociales promotora individual grupal

ABSTRACT The aim of this study was to adapt and validate the Spanish version of the Cooperative Learning Scale (CAT) for Portuguese and Brazilian higher education students. The study included 493 higher education students aged 17-45 years from a university in northern Portugal and 414 Brazilian university students aged 14-52 years from different universities in Brazil. To this adaptation, the original instrument, designed and validated for Spanish contexts and for students from the 3rd cycle of basic education and secondary education, went through several phases: a) evaluation by experts; b) pilot study; c) confirmatory factorial analysis; and d) determination of convergent and divergent validity. Both the Portuguese and the Brazilian versions of the CAT present a good adjustment model and include five factors with three items each: positive interdependence, interpersonal skills, promotive interaction, individual accountability, and group processing. (CAT 49 1745 17 45 17-4 41 1452 14 52 14-5 Brazil adaptation instrument rd phases experts b c analysis d validity each interdependence skills interaction accountability processing 4 174 1 17- 145 5 14-

RESUMO O objetivo deste estudo foi adaptar e validar a versão espanhola da Escala de Aprendizagem Cooperativa (EAC) para estudantes portugueses e brasileiros do ensino superior. Participaram no estudo 493 estudantes do Ensino Superior com idades entre 17 e 45 anos de uma universidade do norte de Portugal e 414 estudantes universitários brasileiros com idades entre 14 e 52 anos de universidades do Brasil. Para a adaptação, o instrumento original, desenhado e validado para contextos espanhóis para alunos do 3.º ciclo dos Ensinos Básico e Secundário, passou por várias fases: a) avaliação por especialistas; b) estudo piloto; c) análise fatorial confirmatória; e d) determinação da validade convergente e divergente. A versão portuguesa e a brasileira da EAC apresentam um bom modelo de ajustamento e incluem cinco fatores com três itens cada: interdependência positiva, competências interpessoais, interação estimuladora, responsabilidade individual e de grupo e processo de grupo. (EAC superior 49 1 4 41 5 Brasil adaptação original 3º º 3 Secundário fases especialistas b piloto c confirmatória d divergente cada positiva interpessoais estimuladora

Nitrocarburized coating by plasma electrolytic saturation, PEN/C coatings, have been proposed to increase the corrosion and wear resistance of steel by using a process of low-temperature hydrostatic plasma. The objective of this work is to analyse the wear and corrosion resistance of PEN/C coatings on SAE 1045 steel, using the electrochemical slurry erosion wear test (ESEWT). This test allows the evaluation of the simultaneous effect of erosion wear and electrochemical behaviour on this coating. Thus, it was possible to evaluate the erosive and corrosive effect and the synergy of these phenomena on the PEN/C coated SAE 1045 mass loss rates. ESEWT tests were performed at different times and under different electrochemical conditions: under cathodic protection and open circuit potential (OCP). The PEN/C coating increased the corrosion resistance of SAE 1045. Synergy between the erosive wear and corrosion was the main factor in the mass loss rates of both analysed systems. The synergistic mechanism of the substrate occurred by removing the corrosion product and by activating the surface generated by the erosive process of the particles. The synergistic mechanism of the PEN/C coating occurred with the removal of inherent surface irregularities through the erosive process, combined with localized corrosion. saturation PENC PEN C lowtemperature low temperature 104 ESEWT. . (ESEWT) Thus conditions OCP. OCP (OCP) systems particles 10 (ESEWT (OCP 1

ABSTRACT The use growth regulators from the cytokinins and auxins group has been shown to increase the productivity of certain crops, as they may be involved in the expression of plant sex, although little is known about the action of auxin IBA and cytokinin CPPU on the fruiting of squash, as well as the interaction between both, which makes this field of study promising. Thus, the objective of this study was to induce the fruiting in Atlas squash, by means of different forms of application and proportions of cytokinin and auxin and to evaluate their effects on the physical-chemical characteristics of the fruits. The treatments were composed of six proportions associated with growth regulators and of two forms of application. The experimental design was a randomized block design with four replicates. At 72 days after transplanting, growth and fruit quality analyses were performed. The behavior of the hormones is modulated by their concentration and place of application, and the effect may be beneficial or not. The proportions 50/50% via leaf and 75/25% via ovary were the ones that increased the growth and parameters of fruit quality. The application of CPPU via leaf at higher concentration in proportion decreases quality characteristics such as vitamin C, carotenoids and starch. crops sex squash both promising Thus physicalchemical physical chemical fruits replicates 7 transplanting performed not 5050 50 50/50 7525 75 25 75/25 C starch 505 5 50/5 752 2 75/2 50/ 75/

RESUMO O uso de reguladores de crescimento do grupo das citocininas e auxinas tem demonstrado aumentar a produtividade de algumas culturas, pois podem estar envolvidos na expressão do sexo da planta, embora pouco se saiba sobre a ação da auxina IBA e da citocinina CPPU na frutificação da abóbora, bem como a interação entre ambas, o que torna este campo de estudo promissor. Assim, o objetivo deste estudo foi induzir a frutificação em abóbora Atlas, por meio de diferentes formas de aplicação e proporções de citocinina e auxina e avaliar seus efeitos nas características físico-químicas dos frutos. Os tratamentos foram compostos por seis proporções associadas a reguladores de crescimento e duas formas de aplicação. O delineamento experimental foi em blocos casualizados com quatro repetições. Aos 72 dias após o transplante, foram realizadas análises de crescimento e qualidade dos frutos. O comportamento dos hormônios é modulado por sua concentração e local de aplicação, podendo o efeito ser benéfico ou não. As proporções 50/50% via folha e 75/25% via ovário foram as que aumentaram o crescimento e os parâmetros de qualidade dos frutos. A aplicação de CPPU via foliar em maior concentração em proporção diminui características de qualidade como vitamina C, carotenoides e amido. culturas planta ambas promissor Assim Atlas físicoquímicas físico químicas frutos repetições 7 transplante não 5050 50 50/50 7525 75 25 75/25 C amido 505 5 50/5 752 2 75/2 50/ 75/

ABSTRACT: In order to establish protocols that can contribute to the propagation of medicinal plants, this study evaluated the effect of hydropriming and substrates on the emergence and production of Calendula officinalis L. seedlings. Seeds were submitted or not to hydropriming for 24 hours, and subsequent sowing in four substrates: S1) 100% Dystroferric Red Latosol - DRL, S2) DRL + coarse sand (1:1 v/v), S3) DRL + Tropstrato® commercial substrate (1:1 v/v) and S4) 100% Tropstrato®, and kept in greenhouse with 50% shading. Higher emergence percentage in substrates with the presence of DRL was observed. Seed hydropriming impaired seedling emergence, but contributed to root growth, biomass production and seedling quality. The 100% Tropstrato® substrate favored higher dry mass production and seedling quality. Positive linear correlation (≥ 0.70) was observed between shoot and root growth characteristics with biomass production and Dickson’s quality index. Principal component analysis explained 78.95% of the experimental variance, excluding the first count and the shoot/root ratio with low representativeness. In the cluster analysis of Euclidean distances, seedlings with the greatest similarity were those produced with 100% DRL and DRL + Tropstrato® with and without hydropriming, respectively. Dystroferric Red Latosol is recommended pure or combined with Tropstrato® for the production of C. officinalis L seedlings, and the hydropriming impaired seedling emergence characteristics. ABSTRACT plants 2 hours S1 S 100 S2 11 1 (1: v/v, vv v/v , v S3 Tropstrato S4 50 shading ≥ ( 0.70 070 0 70 Dicksons Dickson s index 7895 78 95 78.95 variance shootroot representativeness distances respectively C 10 (1 5 0.7 07 7 789 9 78.9 0. 78.

RESUMO: Com a finalidade de estabelecer protocolos que possam contribuir na propagação de plantas medicinais, objetivamos, com este estudo, avaliar o efeito do hidrocondicionamento e substratos na emergência e produção de mudas de Calendula officinalis L. As sementes foram submetidas ou não ao hidrocondicionamento durante 24 horas, e posterior semeadura em quatro substratos: S1) 100% Latossolo Vermelho Distroférrico - LVD, S2) LVD + areia grossa (1:1, v/v), S3) LVD + substrato comercial Tropstrato® (1:1, v/v) e S4) 100% Tropstrato®, e mantidas em viveiro com 50% de sombreamento. Observamos maior percentagem de emergência nos substratos com presença de LVD. O hidrocondicionamento das sementes prejudicou a emergência das plântulas, mas contribuiu no crescimento de raiz, produção de biomassa e qualidade das mudas. O substrato 100% Tropstrato® favoreceu maior produção de massa seca e qualidade das mudas. Observamos correlação linear positiva (≥ 0,70) entre as características de crescimento da parte aérea e raiz com produção de biomassa e o índice de qualidade de Dickson. A análise de componentes principais explicou 78,95% da variância experimental, excluindo a primeira contagem e a relação parte aérea/raiz com baixa representatividade. Na análise de agrupamento das distâncias Euclidianas, as mudas com maior similaridade foram aquelas produzidas no 100% LVD e LVD + Tropstrato® com e sem hidrocondicionamento, respectivamente. Recomenda-se o Latossolo Vermelho Distroférrico puro ou combinado com Tropstrato® para a produção de mudas de C. officinalis L., e o hidrocondicionamento prejudicou as características de emergência das plântulas. RESUMO medicinais objetivamos estudo L 2 horas S1 S 100 S2 11, 11 1 1, (1:1 v/v, vv v/v , v S3 Tropstrato S4 50 sombreamento plântulas ≥ ( 0,70 070 0 70 Dickson 7895 78 95 78,95 experimental aérearaiz representatividade Euclidianas respectivamente Recomendase Recomenda se C 10 (1: 5 0,7 07 7 789 9 78,9 (1 0, 78,

ABSTRACT This study aimed to characterize the occurrence, duration, and intensity of the flushes of vegetative growth in two peach cultivars of Prunus persica L. Batsch, grown as a pioneer endeavor at a high-altitude tropical climate site in the State of Minas Gerais, Brazil. The observational experiment was carried out in 2017/18 and 2018/19 on the ‘Tropic Beauty’ and ‘BRS Kampai’ cultivars by an evaluation of the number and duration of flushes of vegetative growth during the year over two cycles. The number of fruit-bearing shoots, total number of leaves and shoot length were also assessed. At harvest, fruit load and diameter were determined and grouped into diameter ranges. The number of hours recorded at different temperature ranges, < 10.0 °C; 10.1-15.0 °C; 15.1-20.0 °C; 20.1-25.0 °C; > 25.1 °C, were summed separately and divided into daily and nightly periods. The peach tree has an unusual vegetative growth pattern when cultivated in a tropical area, which occurs in two flushes, with the first flush occurring from budbreak to fruit harvest between June and Sept, forming short shoots (less than 10 cm), with early shoot growth cessation, with a limited leaf number that can potentially diminish the supply of carbohydrates to the fruit, leading to smaller growth. The second flush occurs after harvest, between Oct and Dec, when there is an increase in daily temperature and precipitation, and no competition with fruits. Notabily, these second flush shoots grow with greater vigor and regularization of the growth cycle, forming fruit-bearing shoots with abundant leaf and flower buds for the next production cycle. occurrence L Batsch highaltitude high altitude Gerais Brazil 201718 2017 18 2017/1 201819 2018 19 2018/1 Tropic Beauty BRS Kampai cycles fruitbearing bearing assessed ranges 100 0 10. °C C 10.115.0 101150 10.1 15.0 1 15 10.1-15. 15.120.0 151200 15.1 20.0 20 15.1-20. 20.125.0 201250 20.1 25.0 25 20.1-25. 251 25. periods area Sept less cm, cm , cm) cessation Dec precipitation fruits Notabily cycle 20171 201 2017/ 20181 2018/ 115 10.115. 10115 101 150 15. 10.1-15 120 15.120. 15120 151 200 20. 2 15.1-20 125 20.125. 20125 250 20.1-25 11 10.115 1011 10.1-1 12 15.120 1512 15.1-2 20.125 2012 20.1-2 10.11 10.1- 15.12 15.1- 20.12 20.1-

ABSTRACT The objective of this research was to evaluate leaf temperature, and watermelon yield components under wetted area percentages (PW) in irrigation located in the Agreste region of Northeastern Brazil. Two experiments were carried out in 2018 and 2019. The adopted statistical design was randomized blocks, with six replications and four treatments, in 2018: P1 = 13%, P2 = 14%, P3 = 19%, and P4 = 22%, in 2019: P5 = 12%, P6 = 15%, P7 = 16%, and P8 = 21% of PW. The meteorological variables analyzed were: air temperature (Ta) and rain. The experimental evaluations consisted of measuring the temperature of the plant’s vegetative canopy, tensiometry, mass, and BRIX. Air temperature was not a limiting factor for watermelon growth and development. The average was 195.88 mm, and the average leaf temperature of watermelon is 29.5 °C, a value lower than Ta. There was no statistically significant difference for fruit mass and BRIX, where the overall mean was 10.82 and 10.46 kg, respectively. Therefore, it is feasible to irrigate watermelon with wetted area percentages ranging from 12 to 22%, in localized irrigation systems, without generating physiological damage and reducing agricultural productivity and fruit quality. PW (PW Brazil 201 2019 blocks treatments P 13 13% 14 14% 19 19% 22 22% 12% 15 15% 16 16% 21 Ta (Ta rain plants plant s canopy tensiometry BRIX development 19588 195 88 195.8 mm 295 29 5 29. C °C 1082 10 82 10.8 1046 46 10.4 kg respectively Therefore 1 systems quality 20 2 1958 8 195. 108 10. 104 4

Resumen: Con la emergencia de la pandemia de Covid-19, las(os) psicólogas(os) comenzaron a ofrecer atención psicológica en línea a pacientes que hasta entonces eran atendidos de forma presencial. Este cambio se producía a menudo de forma improvisada y sin la formación previa necesaria. Este estudio descriptivo, exploratorio, cuanticualitativo, con enfoque transversal, tuvo como objetivo comprender la experiencia de estos profesionales en la transición del trabajo presencial al remoto durante la pandemia de Covid-19 en Brasil, identificando dificultades y lagunas percibidas en las directrices del Consejo Federal de Psicología. Participaron en la investigación 385 psicólogos(as). Para la recogida de datos se utilizó un cuestionario en línea distribuido por plataforma digital entre mayo y noviembre de 2020. El estudio también se difundió en grupos de la categoría profesional de la Psicología en diversas redes sociales. Los datos cuantitativos se analizaron mediante análisis estadístico descriptivo, y las respuestas a las preguntas abiertas mediante análisis temático reflexivo. Los resultados se organizaron en tres categorías temáticas: (a) lagunas percibidas en la orientación sobre la elección de la plataforma digital; (b) lagunas relativas a la realización de la inscripción en el sitio web E-Psi ; y (c) falta de formación adecuada para realizar la transición al formato en línea. Entre los principales resultados, destacaron la inseguridad generada por la falta de preparación previa de los profesionales y la resistencia de algunos clientes a aceptar la transición de los servicios del modelo presencial al modelo en línea. Se espera que el estudio de las principales dificultades a las que se enfrenta la categoría contribuya a matizar el debate sobre la eficacia de las orientaciones puestas a disposición de los(as) psicólogos(as). Resumen Covid19, Covid19 Covid 19, 19 lasos os las(os psicólogasos psicólogas psicólogas(os necesaria descriptivo exploratorio cuanticualitativo transversal Covid-1 Brasil 38 psicólogosas. psicólogosas psicólogos as . psicólogos(as) 2020 sociales reflexivo temáticas (a b (b EPsi E Psi c (c losas los(as Covid1 1 Covid- 3 psicólogos(as 202 20 2

Abstract: With the emergence of the COVID-19 pandemic, psychologists began to offer online consultations to their patients, who were previously seen in person. In most cases, this change happened in an improvised way and with no prior training required. In this context, this study, of a descriptive-exploratory, quanti-qualitative character with cross-sectional design, aimed to understand the experience of psychologists in the transition from in-person to remote modality during the COVID-19 pandemic in Brazil, identifying difficulties and gaps regarding the guidelines provided by the Federal Council of Psychology. A total of 385 psychologists participated in the research. An online questionnaire was used for data collection, distributed via a digital platform between May and November 2020. The study was also shared in professional Psychology groups on several social networks. The quantitative data were analyzed by descriptive statistical analysis, and the answers to the open questions by reflective thematic analysis. The findings were organized into three thematic categories: (a) gaps perceived in the guidance regarding the choice of the digital platform; (b) gaps regarding the completion of the registration on the E-Psi website; and (c) lack of adequate training to make the transition to the online format. Among the main results were the insecurity generated by the lack of previous preparation of the professionals and the resistance of some clients to accept the transposition of the face-to-face services to the online model. It is expected that the mapping of the main difficulties faced by the category will contribute to qualify the debate about the effectiveness of the orientations made available to psychologists. Abstract COVID19 COVID 19 COVID-1 patients person cases required context descriptiveexploratory, descriptiveexploratory exploratory, exploratory descriptive-exploratory quantiqualitative quanti qualitative crosssectional cross sectional design inperson Brazil 38 research collection 2020 networks analysis categories (a b (b EPsi E Psi website c (c format facetoface face model COVID1 1 COVID- 3 202 20 2

Resumo: Com a emergência da pandemia de Covid-19, as(os) psicólogas(os) passaram a oferecer atendimento online para pacientes que até então eram atendidos de forma presencial. Na maior parte dos casos, essa mudança se deu de forma improvisada e sem capacitação prévia. Nesse contexto, este estudo, de caráter descritivo-exploratório, quanti-qualitativo e com delineamento transversal, buscou compreender a experiência das(os) psicólogas(os) na transição das intervenções da modalidade presencial para o atendimento remoto durante a pandemia de Covid-19 no Brasil, identificando dificuldades e lacunas percebidas nas orientações disponibilizadas pelo Conselho Federal de Psicologia. Participaram da pesquisa 385 psicólogas(os). Utilizou-se um questionário online para a coleta dos dados, distribuído por meio de uma plataforma digital entre maio e novembro de 2020. O estudo também foi divulgado em grupos da categoria profissional da psicologia em diversas redes sociais. Os dados quantitativos foram analisados por meio de análise estatística descritiva, e as respostas para as questões abertas por meio de análise temática reflexiva. Os achados foram organizados em três categorias temáticas: (a) lacunas percebidas nas orientações quanto à escolha da plataforma digital; (b) lacunas quanto ao preenchimento do cadastro no site E-Psi ; e (c) falta de treinamento adequado para realizar a transição para o formato online. Entre os principais resultados, destacaram-se a insegurança gerada pela falta de preparo prévio das(os) profissionais e a resistência de alguns clientes a aceitar a transposição dos atendimentos do modelo presencial para o online. Espera-se que o mapeamento das principais dificuldades enfrentadas pela categoria contribua para qualificar o debate sobre a efetividade das orientações disponibilizadas para as(os) psicólogas(os). Resumo Covid19, Covid19 Covid 19, 19 asos as(os psicólogasos psicólogas psicólogas(os casos prévia contexto descritivoexploratório, descritivoexploratório descritivo exploratório, exploratório descritivo-exploratório quantiqualitativo quanti qualitativo transversal dasos das(os Covid-1 Brasil Psicologia 38 psicólogasos. . Utilizouse Utilizou 2020 sociais descritiva reflexiva temáticas (a b (b EPsi E Psi c (c resultados destacaramse destacaram Esperase Espera Covid1 1 Covid- 3 202 20 2

Abstract Background: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. There is no effective treatment for neurodegenerative diseases. Snake venoms are a cocktail of proteins and peptides with great therapeutic potential and might be useful in the treatment of neurodegenerative diseases. Crotapotin is the acid chain of crotoxin, the major component of Crotalus durissus collilineatus venom. PD is characterized by low levels of neurotrophins, and synaptic and axonal degeneration; therefore, neurotrophic compounds might delay the progression of PD. The neurotrophic potential of crotapotin has not been studied yet. Methods: We evaluated the neurotrophic potential of crotapotin in untreated PC12 cells, by assessing the induction of neurite outgrowth. The activation of the NGF signaling pathway was investigated through pharmacological inhibition of its main modulators. Additionally, its neuroprotective and neurorestorative effects were evaluated by assessing neurite outgrowth and cell viability in PC12 cells treated with the dopaminergic neurotoxin MPP+ (1-methyl-4-phenylpyridinium), known to induce Parkinsonism in humans and animal models. Results: Crotapotin induced neuritogenesis in PC12 cells through the NGF-signaling pathway, more specifically, by activating the NGF-selective receptor trkA, and the PI3K/Akt and the MAPK/ERK cascades, which are involved in neuronal survival and differentiation. In addition, crotapotin had no cytotoxic effect and protected PC12 cells against the inhibitory effects of MPP+ on cell viability and differentiation. Conclusion: These findings show, for the first time, that crotapotin has neurotrophic/neuroprotective/neurorestorative potential and might be beneficial in Parkinson's disease. Additional studies are necessary to evaluate the toxicity of crotapotin in other cell models. Background Parkinsons Parkinson s (PD diseases crotoxin venom neurotrophins degeneration therefore yet Methods PC PC1 modulators Additionally MPP 1methyl4phenylpyridinium, 1methyl4phenylpyridinium methylphenylpyridinium 1 methyl 4 phenylpyridinium , (1-methyl-4-phenylpyridinium) models Results NGFsignaling specifically NGFselective selective trkA PI3KAkt PIKAkt PI3K Akt PI K MAPKERK MAPK ERK cascades differentiation addition Conclusion show time neurotrophicneuroprotectiveneurorestorative (1-methyl-4-phenylpyridinium KAkt PIK

ABSTRACT The continuous demand for water in the agricultural sector has encouraged researchers worldwide to find alternatives to optimize this resource. The use of wastewater in irrigation is promising in this scenario, especially to produce tree seedlings. The growth, quality, and water productivity of Dalbergia nigra seedlings cultivated with sewage sludge were determined when irrigated with urban supply water (W1) and cattle wastewater (CWW) treated for 1 h (W2) and 2 h (W3) of ozonation, considering four irrigation depths and shading levels (0 % (C1), 37.6 % (C2), 49.4 % (C3), 75.8 % (C4)). The height, stem diameter, biomass, and the Dickson Quality Index (DQI) were evaluated. The largest volumes of water applied in each experiment were 2.342 L per plant in W2C1, 2.114 L per plant in W1C3 and 1.556 L per plant in W3C1. The CWW provided satisfactory seedling growth, especially W2, highlighting a DQI of 0.47 obtained in C1 and better water productivity (3.8 g L–1) in W2C1, with full depth. Using alternative inputs in the seedling production of tree species is a promising strategy and indicates benefits for waste disposal, such as sewage sludge and wastewater. resource scenario growth quality W1 W (W1 (CWW W2 (W2 W3 (W3 ozonation 0 ( C1, C , (C1) 376 37 6 37. C2, C2 (C2) 494 49 4 49. C3, C3 (C3) 758 75 8 75. C4. C4 . (C4)) height diameter biomass (DQI evaluated 2342 342 2.34 W2C1 WC 2114 114 2.11 W1C 1556 556 1.55 W3C1 047 47 0.4 3.8 38 3 (3. L–1 L1 depth disposal (W (C1 (C2 (C3 7 (C4) 234 34 2.3 W2C 211 11 2.1 155 55 1.5 W3C 04 0. 3. (3 L– (C (C4 23 2. 21 15 5 1.

ABSTRACT Objective: To report the case of a girl presenting a severe phenotype of mandibuloacral dysplasia type A (MADA) characterized by prominent osteolytic changes and ectodermal defects, associated with a rare homozygous LMNA missense mutation (c.1579C>T). Case description: A 6-year-old girl was evaluated during hospitalization exhibiting the following dysmorphic signs: subtotal alopecia, dysmorphic facies with prominent eyes, marked micrognathia and retrognathia, small beaked nose, teeth crowding and thin lips, generalized lipodystrophy, narrow and sloping shoulders, generalized joint stiffness and bone reabsorption in the terminal phalanges. In dermatological examination, atrophic skin, loss of cutaneous elasticity, hyperkeratosis, dermal calcinosis, and hyperpigmented and hypochromic patches were observed. Radiology exams performed showed bilateral absence of the mandibular condyles, clavicle resorption with local amorphous bone mass confluence with the scapulae, shoulder joints with subluxation and severe bone dysplasia, hip dysplasia, osteopenia and subcutaneous calcifications. Comments: MADA is a rare autosomal recessive disease caused by mutations in LMNA gene. It is characterized by craniofacial deformities, skeletal anomalies, skin alterations, lipodystrophy in certain regions of the body and premature ageing. Typical MADA is caused by the p.R527H mutation in the LMNA gene. However, molecular analysis performed from oral epithelial cells obtained from the patient showed the rare mutation c.1579C>T, p. R527C in the exon 9 of LMNA. This is the sixth family identified with this mutation described in the literature. Objective (MADA defects c.1579C>T. c1579CT cCT c.1579C>T . c 1579C T C (c.1579C>T) description 6yearold yearold 6 year old signs alopecia eyes retrognathia nose lips shoulders phalanges examination elasticity hyperkeratosis calcinosis observed condyles scapulae calcifications Comments gene deformities anomalies alterations ageing pR527H pRH p R527H R H However RC literature CT (c.1579C>T pR RH

RESUMO Objetivo: Relatar o caso de uma jovem que apresentava um fenótipo grave de displasia mandibuloacral tipo A (MADA) caracterizado por alterações osteolíticas proeminentes e defeitos ectodérmicos, associados a uma rara mutação homozigótica missense no gene LMNA (c.1579C>T). Descrição do caso: Uma menina de seis anos foi avaliada durante hospitalização apresentando os seguintes sinais dismórficos: alopecia subtotal, fácies dismórfica com olhos proeminentes, micrognatia e retrognatia acentuada, nariz pequeno e adunco, dentes apinhados e lábios finos, lipodistrofia generalizada, ombros estreitos e inclinados, rigidez articular e reabsorção óssea nas falanges terminais. Ao exame dermatológico, observou-se pele atrófica, perda da elasticidade cutânea, hiperceratose, calcinose dérmica e manchas hiperpigmentadas e hipocrômicas. Exames radiológicos realizados mostraram ausência de côndilos mandibulares bilaterais, reabsorção da clavícula com massa óssea amorfa local confluindo com as escápulas, articulações do ombro com subluxação e displasia óssea severa, com displasia coxofemoral, osteopenia e calcificações subcutâneas. Comentários: MADA é uma doença autossômica recessiva rara causada por mutações no gene LMNA. Caracteriza-se por deformidades craniofaciais, anomalias esqueléticas, alterações cutâneas, lipodistrofia em determinadas regiões do corpo e envelhecimento precoce. MADA típica é causada pela mutação p.R527H no gene LMNA. No entanto, a análise molecular realizada com células epiteliais orais obtidas da paciente mostrou a mutação rara c.1579C>T, p. R527C no exon 9 do gene LMNA. Esta é a sexta família identificada com essa mutação descrita na literatura. Objetivo (MADA ectodérmicos c.1579C>T. c1579CT cCT c.1579C>T . c 1579C T C (c.1579C>T) dismórficos subtotal acentuada adunco finos generalizada inclinados terminais dermatológico observouse observou se atrófica cutânea hiperceratose hipocrômicas bilaterais escápulas severa coxofemoral subcutâneas Comentários Caracterizase Caracteriza craniofaciais esqueléticas cutâneas precoce pR527H pRH p R527H R H entanto RC literatura CT (c.1579C>T pR RH

Abstract Background Approximately 30 % of cardiac surgeries are conducted on women by median sternotomy, which often causes discomfort such as pain, affects quality of life, and delayed recovery compared with men. Breast size is related to operative wound complications, such as incisional pain, sternum dehiscence, and infection, which may affect hospital costs due to prolonged hospital stays. Objective To evaluate breast size and operative wound complications and the effect of breast support on the incidence of pain, infection, and quality of life in women after coronary artery bypass grafting. Method Women were randomly assigned to one of three groups: group A (surgical breast support), group B (ordinary breast support), and group C (no-support). Observations were taken daily between the second and seventh postoperative days and at 30, 60, and 180 days. Pain was assessed using the Short-Form 36 Health Survey (SF36) for quality of life and a verbal numerical scale. The authors used the nonparametric Kruskal-Wallis and Friedman tests to examine variance. The authors used the Pearson correlation coefficient or the Spearman correlation for correlations between variables. A multivariate study was conducted to evaluate the occurrence of infection, and the logistic regression model with “stepwise” variable selection was used. A linear regression model with the “stepwise” variable selection was also used for hospitalization. The authors used SPSS 17.0 software for Windows, with a significance level of p < 0.05. Results There was no difference in pain evaluation between the groups in 190 women (p > 0.05). When comparing quality of life, there was a statistically significant difference in the functional capacity domain at 30 and 60 days, with group A having the best functional capacity (p < 0.05). The larger the breast size, the longer the hospital stay (p < 0.001) and the higher the probability of infection (p = 0.032). Patients with a history of stroke had a 3.8 higher incidence of infection (p = 0.040). Conclusion The use of surgical support did not affect acute pain or sternal infection rate in the 6-month follow-up. However, it was effective in the functional capacity domain 30 days after surgery and maintained at 60 days. 3 sternotomy men dehiscence stays grafting support, , support) ordinary nosupport. nosupport . (no-support) 18 ShortForm Short Form SF36 SF (SF36 scale KruskalWallis Kruskal Wallis variance variables stepwise “stepwise hospitalization 170 17 0 17. Windows 005 05 0.05 19 0.05) 6 0.001 0001 001 0.032. 0032 0.032 032 0.032) 38 8 3. 0.040. 0040 0.040 040 0.040) 6month month followup. followup follow up. up follow-up However (no-support 1 SF3 (SF3 00 0.0 0.00 000 003 0.03 03 004 0.04 04 (SF 0.

Abstract Since the inception of COVID-19 pandemic, there has been a challenging race for the development of precise diagnostic tests. Specific SARS-CoV-2 serological assays are the main tools used to estimate the rate of past infections or herd immunity in epidemiological studies, in addition to being helpful in guiding public health management policies. In this study, an in-house ELISA based on the construct of SARS-CoV-2 nucleocapsid (N) proteins, named rCoV2, rCoV4, and rCoV7, showed diagnostic performance for the detection of IgG antibodies. Sensitivity was evaluated in serum samples from patients with mild to moderate or severe COVID-19 infections, which were collected at different time points, while specificity was evaluated using pre-pandemic sera. In samples from mild to moderate cases obtained ≥16 days after the onset of symptoms, the sensitivities for rCoV2, rCoV4, and rCoV7 were 66.7%, 75%, and 77.8%, respectively. For samples from severe cases, the sensitivity was above 80% for all constructs. All proteins showed high specificity (94-98%). Overall, rCoV7 (C-terminus N-protein portion) showed better diagnostic performance, with 62.3% sensitivity in moderate and severe cases and 96.6% specificity. The SARS-CoV-2 ELISA using N-protein-based constructs could be a promisor tool for investigate the epidemiology of COVID-19 and monitor population-level serosurveillance. COVID19 COVID 19 COVID-1 pandemic tests SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- studies policies study inhouse house N (N rCoV2 rCoV rCoV4 antibodies points prepandemic pre sera 16 ≥1 symptoms 667 66 7 66.7% 75 75% 778 77 8 77.8% respectively 80 9498%. 9498 94 98% . 98 (94-98%) Overall Cterminus C terminus Nprotein protein portion 623 62 3 62.3 966 96 6 96.6 Nproteinbased populationlevel population level serosurveillance COVID1 1 COVID- SARS-CoV ≥ 66.7 77.8 9498% 949 9 (94-98% 62. 96. 66. 77. (94-98 (94-9 (94- (94 (9 (

ABSTRACT. The aim of this study was to investigate the hair coat characteristics of sows raised in a free-range system in a tropical climate and assess associations with effective radiative properties and thermal conductivity. Bristles were collected from December 2017 to April 2018 and evaluated for diameter (mm), length (mm), and density (bristles per cm2). From these data, the effective thermal conductivity, absorptivity, transmissivity, and reflectivity of the hair coat were determined. Sows were separated into four groups according to skin pigmentation and color parameters. The environment was characterized with regard to average air temperature (°C), relative humidity (%), and shortwave radiation (W m-2). The data were analyzed by repeated measures analysis. Bristle length (33 mm) and density (10 bristles cm-2) were lower in summer than in colder months (48 mm and 20 bristles cm-2, respectively). Effective absorptivity was higher and transmittance was lower in more pigmented sows, demonstrating a connection with protection against solar radiation. Therefore, the combination of a pigmented and dense coat seems to be ideal for pigs reared in free-range systems. ABSTRACT freerange free range conductivity 201 mm, , (mm) cm2. cm2 cm . cm2) transmissivity determined parameters °C, C °C (°C) %, % (%) W m2. m2 m 2 m-2) analysis 33 (3 10 (1 cm-2 48 (4 cm2, 2, respectively. respectively respectively) Therefore systems (mm (°C (% m-2 3 ( 1 cm- 4 m-

ABSTRACT The thermal modification of wood is a process that alters its chemical composition, aiming to improve technological properties such as dimensional stability, reduction of equilibrium moisture content, homogeneity, or color. In this context, this study aimed to evaluate the colorimetry and chemical properties of the wood of Parkia pendula (angelim-saia) and Simarouba amara (marupá) that was thermally modified by different methods. Three treatments were evaluated: T1 (pre-treatment in an oven for one hour at 120 °C and treatment in an oven at 180 °C for three hours); T2 (pre-treatment in an autoclave at 125 °C for three hours under 1.2 kgf cm-2 and treatment in an oven at 180 °C for three hours); and T3 (without pre-treatment, with sample treatment in vegetable oil). The thermally modified wood was evaluated in relation to untreated wood for structural chemical composition (extractives, lignin, holocellulose and ash content), colorimetric parameters defined through the CIELAB (Commission Internationale de l´Eclairage) system and total color variation. We detected a significant increase in extractives content and a decrease in holocellulose and lignin content in T3 for both species, which can be explained by the impregnation of oil in the wood samples. The thermal modification caused the surface darkening of the wood of both species, which was more pronounced in P. pendula. Despite the colorimetric change, there was no chemical damage to the wood. stability homogeneity context angelimsaia angelim saia (angelim-saia marupá (marupá methods T pretreatment pre 12 C 18 hours) 1 2 1. cm2 cm cm- without pretreatment, treatment, pre-treatment oil. . oil) extractives, (extractives , content) Commission l´Eclairage lEclairage l Eclairage variation species samples P change

RESUMO A modificação térmica da madeira é um processo que altera sua composição química, visando melhorar propriedades tecnológicas como estabilidade dimensional, redução do teor de umidade de equilíbrio, homogeneidade ou cor. Neste contexto, este estudo teve como objetivo avaliar a colorimetria e as propriedades químicas da madeira de Parkia pendula (angelim-saia) e Simarouba amara (marupá) modificada termicamente por diferentes métodos. Foram avaliados três tratamentos: T1 (pré-tratamento em estufa por uma hora a 120 °C e tratamento em estufa a 180 °C por três horas); T2 (pré-tratamento em autoclave a 125 °C por três horas sob 1,2 kgf cm-2 e tratamento em estufa a 180 °C por três horas); T3 (sem pré-tratamento, com tratamento da amostra em óleo vegetal). A madeira termicamente modificada foi avaliada em relação à madeira não tratada quanto à composição química estrutural (extrativos, lignina, holocelulose e teor de cinzas), parâmetros colorimétricos definidos através do sistema CIELAB (Commission Internationale de l´Eclairage) e variação total de cores. Detectamos um aumento significativo no teor de extrativos e uma diminuição no teor de holocelulose e lignina em T3 para ambas espécies, o que pode ser explicado pela impregnação de óleo nas amostras de madeira. A modificação térmica provocou o escurecimento superficial da madeira de ambas espécies, que foi mais pronunciado em P. pendula. Apesar da alteração colorimétrica, quimicamente não houve prejuízos para as madeiras. dimensional equilíbrio cor contexto angelimsaia angelim saia (angelim-saia marupá (marupá métodos tratamentos T prétratamento pré 12 C 18 horas) 1 2 1, cm2 cm cm- sem prétratamento, tratamento, pré-tratamento vegetal. vegetal . vegetal) extrativos, (extrativos cinzas, cinzas , cinzas) Commission l´Eclairage lEclairage l Eclairage cores espécies P colorimétrica madeiras