Pesquisa | SciELO

ABSTRACT: Using non-destructive and low-cost methods to determine leaf area has gained important applications. The research objectives were (i) to propose a non-destructive method to estimate the leaf area of castor bean crops and (ii) to build equations that accurately and quickly estimate the leaf area of specie. One thousand healthy and expanded leaves of five castor bean cultivars (New Zealand Purple, Sipeal, Carmencita, Amarelo de Irecê, and IAC-80) were collected, and 200 leaves were collected from each. The maximum length, maximum width, and leaf area were calculated for each leaf. The product between length and width (LW) were calculated. We performed tests with different linear and non-linear regression models between leaf area and linear leaf dimensions of each cultivar. The models used were linear, linear without intercept, and power. The criteria for choosing the best models to estimate the leaf area of castor beans were a higher coefficient of determination, more elevated Pearson’s linear correlation coefficient, lower Akaike information criterion, higher Willmott agreement index, and smallest root mean square error. The equations that presented the best criteria for estimating the leaf area of castor bean cultivars were those that used the product between length and width, compared to equations that used only one leaf dimension. The model ŷ = 0.439 × LW can be used to accurately and quickly estimate the castor bean leaf area through linear measurements of the leaves, using the product between length and width (LW), regardless of the cultivar chosen. ABSTRACT nondestructive non destructive lowcost low cost applications i (i ii (ii specie New Purple Sipeal Carmencita Irecê IAC80 IAC 80 IAC-80 20 (LW nonlinear intercept power determination Pearsons Pearson s criterion index error dimension 0439 0 439 0.43 LW, , chosen IAC8 8 IAC-8 2 043 43 0.4 IAC- 04 4 0.

RESUMO: O uso de métodos não destrutivos e de baixo custo para determinação de área foliar tem ganhado importantes aplicações. Os objetivos da pesquisa foram (i) propor um método não destrutivo para estimar a área foliar da cultura da mamona e (ii) construir equações que estimem com precisão e rapidez a área foliar da espécie. Foram coletadas mil folhas sadias e expandidas de cinco cultivares de mamona (New Zealand Purple, Sipeal, Carmencita, Amarelo de Irecê e IAC-80), sendo coletadas 200 folhas de cada uma. O comprimento máximo, largura máxima e área foliar foram calculados para cada folha. Foi calculado o produto entre comprimento e largura (LW). Foram realizados testes com diferentes modelos de regressão linear e não linear entre área foliar e dimensões lineares das folhas de cada cultivar. Os modelos utilizados foram linear, linear sem intercepto e potência. Os critérios para escolha dos melhores modelos para estimar a área foliar da mamona foram maior coeficiente de determinação, maior coeficiente de correlação linear de Pearson, menor critério de informação de Akaike, maior índice de concordância de Willmott e menor raiz do erro quadrático médio. As equações que apresentaram melhores critérios para estimativa da área foliar das cultivares de mamona foram aquelas que utilizaram o produto entre comprimento e largura, em comparação às equações que utilizaram apenas uma dimensão foliar. O modelo ŷ = 0,439 × LW pode ser utilizado para estimar com precisão e rapidez a área foliar da mamona por meio de medidas lineares das folhas, utilizando o produto entre comprimento e largura (LW), independente da cultivar escolhida. RESUMO aplicações i (i ii (ii espécie New Purple Sipeal Carmencita IAC80, IAC80 IAC 80 , IAC-80) 20 máximo folha LW. . (LW) potência Pearson Akaike médio 0439 0 439 0,43 LW, escolhida IAC8 8 IAC-80 2 (LW 043 43 0,4 IAC-8 04 4 0, IAC-

https://doi.org/10.1590/0103-8478cr20230550

Consensus of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) and the Brazilian Ministry of Health - General management of blood and blood products on the tests necessary for the release of exceptional medicines for sickle cell disease Hematology ABHH (ABHH
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Lobo, Clarisse

; Araújo, Aderson

; Antunes, Alexandre de Albuquerque

; Pinto, Ana Cristina Silva

; Godinho, Ariadne Carvalho

; Pires, Cassia Silvestre Mariano

; Matheus, Cinthia Cristina

; Albuquerque, Xerez de

; Neves, Daniele Campos Fontes

; Moreno, Fábio de Lima

; Baldanzi, Giorgio

; Siufi, Grazziella Curado

; Miranda, Heloisa Helena Pereira

; Hankins, Jane

; Aragão, Joice

; Braga, Josefina Aparecida Pellegrini

; Martins, Juliana Touguinha Neves

; Souza, Luciana Campos Costa Machado de

; Figueiredo, Maria Stella

; Oliveira, Mirella Rodrigues

; Cardoso, Patricia Santos Resende

; Pinto, Patricia Costa Alves

; Moura, Patricia Gomes

; Cançado, Rodolfo Delfini

; Araujo, Paulo Ivo Cortez de

; Saad, Sara Olalla

; Loggetto, Sandra Regina

; Fonseca, Teresa Cristina Cardoso

Hematology, Transfusion and Cell Therapy

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Mar 2024, Volume 46 Nº 1 Páginas 67 - 71

Resumo: En | Texto: En | PDF: En

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

https://doi.org/10.1016/j.htct.2024.01.001

Water adsorption isotherms and thermodynamic properties of germinated pumpkin seeds flours
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Moraes, Maria Suiane de

; Queiroz, Alexandre José de Melo

; Figueirêdo, Rossana Maria Feitosa de

; Matos, Joana D’arc Paz de

; Silva, Luís Paulo Firmino Romão da

; Santos, Francislaine Suelia dos

; Silva, Semirames do Nascimento

; Oliveira, Adolfo Pinheiro de

Revista Ciência Agronômica

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2024, Volume 55 elocation e2028373

Resumo: En | Texto: En | PDF: En

ABSTRACT The use of residues resulting from the processing of agricultural products is an widely studied topic, which is justified by the need to reduce costs and by the search for productive sustainability, which has as one of its principles the full use production, reducing waste and therefore increasing the amount of products extracted per unit of area. Residual seeds, resulting from the production of fruit pulps, are rich in nutrients and with the potential to be further improved by the application of germination, increasing the protein content and the content of bioactive compounds. However, in the germination process, the product acquires a high water content, requiring immediate drying and control of the water adsorption kinetics after dehydration. Therefore, the objective of this study was to determine the water adsorption isotherms of germinated seeds flours from pumpkins of three varieties at temperatures of 15, 25 and 35 °C, to obtain the most appropriate mathematical model to describe the hygroscopic behavior and to determine the thermodynamic properties of water adsorption, through the values of the integral isosteric heat, differential entropy, differential enthalpy and Gibbs free energy for the studied conditions. The GAB and Peleg models fit the experimental data well. With increasing water activity, there was a reduction in isosteric heat and entropy. The enthalpy-entropy compensation theory was confirmed. Gibbs free energy was negative for all temperatures, increasing with increasing equilibrium water content, demonstrating that it is a spontaneous process. topic sustainability area pulps compounds However process dehydration Therefore 15 2 3 C °C entropy conditions well activity enthalpyentropy confirmed 1

https://doi.org/10.5935/1806-6690.20240011

Analysis of a supply chain in the ceramic sector: a look at business processes sector
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Silva, Jailson dos Santos

; Leite, Maria Silene Alexandre

Gestão & Produção

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2024, Volume 31 elocation e12021

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Given the importance of structuring organizations in supply chains as a mechanism for competitiveness, as well as process management for the good operational performance of these chains, this article aims to map and analyze the business processes of a supply chain of the ceramic sector located in northeastern Brazil. To achieve the proposed objective, Lambert, Cooper, and Pagh’s (LCP) model of supply chain management is adopted, which comprises, within its analysis dimensions, the mapping of the dimensional structure of the chain, its processes, and management components. As a result, it was possible to characterize the configuration of the chain under analysis, highlighting the company's proximity focused on the upstream direction of the chain and, consequently, the complexity of the supply operations. Furthermore, based on the problems and inefficiencies identified during the mapping of the supply processes, this study proposes suggestions for changes and improvements to the ceramic sector's supply chain analyzed. By providing a detailed analysis of the dimensional structure of the chain, its processes, and managerial components, this article contributes to the continuous improvement of organizations by providing a practical discussion on the structuring of supply processes and emphasizing the importance of overcoming the identified inefficiencies. competitiveness Brazil objective Lambert Cooper Paghs Pagh s LCP (LCP adopted comprises dimensions components result companys company consequently operations Furthermore sectors analyzed

Resumo Tendo em vista a importância da estruturação das organizações em cadeias de suprimentos como mecanismo de competitividade, bem como do gerenciamento de processos para o bom desempenho operacional dessas cadeias, este artigo tem por objetivo mapear e analisar os processos de negócios de uma cadeia de abastecimento do setor cerâmico situada no nordeste brasileiro. Para atingir o objetivo proposto, é adotado o modelo de Lambert, Cooper e Pagh (LCP) de gerenciamento de cadeias de suprimentos, que compreende dentro de suas dimensões de análise, o mapeamento da estrutura dimensional da cadeia, seus processos e componentes gerenciais. Como resultados foi possível caracterizar a configuração da cadeia em análise, destacando-se a proximidade da empresa foco no sentido upstream da cadeia e, consequentemente, a complexidade das operações de abastecimento. Além disso, a partir dos problemas e ineficiências identificados durante o mapeamento dos processos, este estudo propõe sugestões de mudanças e melhorias para a cadeia de abastecimento analisada. Ao oferecer uma análise detalhada da estrutura dimensional da cadeia, seus processos e componentes gerenciais, este artigo contribui para o aprimoramento contínuo das organizações, fornecendo uma discussão prática sobre a estruturação dos processos de abastecimento e destacando a importância de superar as ineficiências identificadas. competitividade brasileiro proposto Lambert LCP (LCP gerenciais destacandose se consequentemente disso analisada identificadas

https://doi.org/10.1590/1806-9649-2024v31e12021

Combinação de Ferramentas de Telecardiologia para Estratificação de Risco Cardiovascular na Atenção Primária: Dados do Estudo PROVAR+ Primária PROVAR
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Fraga, Lucas Leal

; Nascimento, Bruno Ramos

; Haiashi, Beatriz Costa

; Ferreira, Alexandre Melo

; Silva, Mauro Henrique Agapito

; Ribeiro, Isabely Karoline da Silva

; Silva, Gabriela Aparecida

; Vinhal, Wanessa Campos

; Coimbra, Mariela Mata

; Silva, Cássia Aparecida

; Machado, Cristiana Rosa Lima

; Pires, Magda C.

; Diniz, Marina Gomes

; Santos, Luiza Pereira Afonso

; Amaral, Arthur Maia

; Diamante, Lucas Chaves

; Fava, Henrique Leão

; Sable, Craig

; Nunes, Maria Carmo Pereira

; Ribeiro, Antonio Luiz P.

; Cardoso, Clareci Silva

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 2 elocation e20230653

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background: Tele-cardiology tools are valuable strategies to improve risk stratification. Objective: We aimed to evaluate the accuracy of tele-electrocardiography (ECG) to predict abnormalities in screening echocardiography (echo) in primary care (PC). Methods: In 17 months, 6 health providers at 16 PC units were trained on simplified handheld echo protocols. Tele-ECGs were recorded for final diagnosis by a cardiologist. Consented patients with major ECG abnormalities by the Minnesota code, and a 1:5 sample of normal individuals underwent clinical questionnaire and screening echo interpreted remotely. Major heart disease was defined as moderate/severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion, or wall-motion abnormalities. Association between major ECG and echo abnormalities was assessed by logistic regression as follows: 1) unadjusted model; 2) model 1 adjusted for age/sex; 3) model 2 plus risk factors (hypertension/diabetes); 4) model 3 plus history of cardiovascular disease (Chagas/rheumatic heart disease/ischemic heart disease/stroke/heart failure). P-values < 0.05 were considered significant. Results: A total 1,411 patients underwent echo; 1,149 (81%) had major ECG abnormalities. Median age was 67 (IQR 60 to 74) years, and 51.4% were male. Major ECG abnormalities were associated with a 2.4-fold chance of major heart disease on echo in bivariate analysis (OR = 2.42 [95% CI 1.76 to 3.39]), and remained significant after adjustments in models (p < 0.001) 2 (OR = 2.57 [95% CI 1.84 to 3.65]), model 3 (OR = 2.52 [95% CI 1.80 to3.58]), and model 4 (OR = 2.23 [95%CI 1.59 to 3.19]). Age, male sex, heart failure, and ischemic heart disease were also independent predictors of major heart disease on echo. Conclusions: Tele-ECG abnormalities increased the likelihood of major heart disease on screening echo, even after adjustments for demographic and clinical variables. Background Telecardiology Tele cardiology stratification Objective teleelectrocardiography tele electrocardiography (ECG (echo PC. . (PC) Methods months protocols TeleECGs ECGs cardiologist code 15 5 1: remotely moderatesevere moderate severe dysfunctionhypertrophy dysfunction hypertrophy dysfunction/hypertrophy effusion wallmotion wall motion follows age/sex agesex sex hypertension/diabetes hypertensiondiabetes hypertension diabetes (hypertension/diabetes) Chagas/rheumatic Chagasrheumatic Chagas rheumatic diseaseischemic diseasestrokeheart stroke failure. failure failure) Pvalues P values 005 0 05 0.0 Results 1411 411 1,41 1149 149 1,14 81% 81 (81% IQR 74 years 514 51 51.4 2.4fold 24fold fold 2.4 OR 242 42 95% 95 [95 176 76 1.7 3.39, 339 3.39 , 39 3.39]) p 0.001 0001 001 257 57 2.5 184 84 1.8 3.65, 365 3.65 65 3.65]) 252 52 180 80 to3.58, to358 to3.58 to3 58 to3.58]) 223 23 2.2 95%CI 95CI 159 59 1.5 3.19. 319 3.19 19 3.19]) Age Conclusions TeleECG variables (PC (hypertension/diabetes 00 0. 141 41 1,4 114 14 1,1 8 (81 7 51. 4fold 24 2. 9 [9 1. 33 3.3 3.39] 0.00 000 25 18 36 3.6 3.65] to35 to3.5 to3.58] 22 31 3.1 3.19] 1, 11 (8 [ 3. to3. (

Resumo Fundamento: As ferramentas de telecardiologia são estratégias valiosas para melhorar a estratificação de risco. Objetivo: Objetivamos avaliar a acurácia da tele-eletrocardiografia (ECG) para predizer anormalidades no ecocardiograma de rastreamento na atenção primária. Métodos: Em 17 meses, 6 profissionais de saúde em 16 unidades de atenção primária foram treinados em protocolos simplificados de ecocardiografia portátil. Tele-ECGs foram registrados para diagnóstico final por um cardiologista. Pacientes consentidos com anormalidades maiores no ECG pelo código de Minnesota e uma amostra 1:5 de indivíduos normais foram submetidos a um questionário clínico e ecocardiograma de rastreamento interpretado remotamente. A doença cardíaca grave foi definida como doença valvular moderada/grave, disfunção/hipertrofia ventricular, derrame pericárdico ou anormalidade da motilidade. A associação entre alterações maiores do ECG e anormalidades ecocardiográficas foi avaliada por regressão logística da seguinte forma: 1) modelo não ajustado; 2) modelo 1 ajustado por idade/sexo; 3) modelo 2 mais fatores de risco (hipertensão/diabetes); 4) modelo 3 mais história de doença cardiovascular (Chagas/cardiopatia reumática/cardiopatia isquêmica/AVC/insuficiência cardíaca). Foram considerados significativos valores de p < 0,05. Resultados: No total, 1.411 pacientes realizaram ecocardiograma, sendo 1.149 (81%) com anormalidades maiores no ECG. A idade mediana foi de 67 anos (intervalo interquartil de 60 a 74) e 51,4% eram do sexo masculino. As anormalidades maiores no ECG se associaram a uma chance 2,4 vezes maior de doença cardíaca grave no ecocardiograma de rastreamento na análise bivariada (OR = 2,42 [IC 95% 1,76 a 3,39]) e permaneceram significativas (p < 0,001) após ajustes no modelo 2 (OR = 2,57 [IC 95% 1,84 a 3,65]), modelo 3 (OR = 2,52 [IC 95% 1,80 a 3,58]) e modelo 4 (OR = 2,23 [IC 95% 1,59 a 3,19]). Idade, sexo masculino, insuficiência cardíaca e doença cardíaca isquêmica também foram preditores independentes de doença cardíaca grave no ecocardiograma. Conclusões: As anormalidades do tele-ECG aumentaram a probabilidade de doença cardíaca grave no ecocardiograma de rastreamento, mesmo após ajustes para variáveis demográficas e clínicas. Fundamento Objetivo teleeletrocardiografia tele eletrocardiografia (ECG Métodos meses portátil TeleECGs Tele ECGs cardiologista 15 5 1: remotamente moderadagrave moderada moderada/grave disfunçãohipertrofia disfunção hipertrofia ventricular motilidade forma idade/sexo idadesexo hipertensão/diabetes hipertensãodiabetes hipertensão diabetes (hipertensão/diabetes) Chagas/cardiopatia Chagascardiopatia Chagas cardiopatia reumáticacardiopatia reumática isquêmicaAVCinsuficiência AVC cardíaca. . cardíaca) 005 0 05 0,05 Resultados total 1411 411 1.41 1149 149 1.14 81% 81 (81% intervalo 74 514 51 51,4 masculino 24 2, OR 242 42 IC 95 176 76 1,7 3,39 339 39 3,39] 0,001 0001 001 257 57 2,5 184 84 1,8 3,65, 365 3,65 , 65 3,65]) 252 52 180 80 3,58 358 58 3,58] 223 23 2,2 159 59 1,5 3,19. 319 3,19 19 3,19]) Idade Conclusões teleECG clínicas (hipertensão/diabetes 00 0,0 141 41 1.4 114 14 1.1 8 (81 7 51, 9 1, 3,3 33 0,00 000 25 18 36 3,6 3,65] 3,5 35 22 31 3,1 3,19] 0, 1. 11 (8 3, (

https://doi.org/10.36660/abc.20230653

Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães

; Barroso, Weimar Kunz Sebba

; Mion Junior, Decio

; Nobre, Fernando

; Mota-Gomes, Marco Antonio

; Jardim, Paulo Cesar Brandão Veiga

; Amodeo, Celso

; Oliveira, Adriana Camargo

; Alessi, Alexandre

; Sousa, Ana Luiza Lima

; Brandão, Andréa Araujo

; Pio-Abreu, Andrea

; Sposito, Andrei C.

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Rodrigues, Cibele Isaac Saad

; Forjaz, Claudia Lucia de Moraes

; Sampaio, Diogo Pereira Santos

; Barbosa, Eduardo Costa Duarte

; Freitas, Elizabete Viana de

; Cestario, Elizabeth do Espirito Santo

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Feitosa, Fabiana Gomes Aragão Magalhães

; Consolim-Colombo, Fernanda Marciano

; Almeida, Fernando Antônio de

; Silva, Giovanio Vieira da

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Guimarães, Isabel Cristina Britto

; Gemelli, João Roberto

; Barreto-Filho, José Augusto Soares

; Vilela-Martin, José Fernando

; Ribeiro, José Marcio

; Yugar-Toledo, Juan Carlos

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano F.

; Bortolotto, Luiz Aparecido

; Alves, Marco Antonio de Melo

; Malachias, Marcus Vinícius Bolívar

; Neves, Mario Fritsch Toros

; Santos, Mayara Cedrim

; Dinamarco, Nelson

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Vitorino, Priscila Valverde de Oliveira

; Miranda, Roberto Dischinger

; Bezerra, Rodrigo

; Pedrosa, Rodrigo Pinto

; Paula, Rogerio Baumgratz de

; Okawa, Rogério Toshiro Passos

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C.

; Lima, Sandro Gonçalves de

; Inuzuka, Sayuri

; Ferreira-Filho, Sebastião Rodrigues

; Fillho, Silvio Hock de Paffer

; Jardim, Thiago de Souza Veiga

; Guimarães Neto, Vanildo da Silva

; Koch, Vera Hermina Kalika

; Gusmão, Waléria Dantas Pereira

; Oigman, Wille

; Nadruz Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 4 elocation e20240113

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20240113

Cannabinoid products for pain management: recommendations from the São Paulo State Society of Anesthesiology management
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Barros, Guilherme Antonio Moreira de

; Pos, Alexandre Mio

; Sousa, Ângela Maria

; Pereira, Carla Leal

; Nobre, Cecília Daniele de Azevedo

; Palmeira, Cláudia Carneiro de Araújo

; Caruy, Cristina Aparecida Arrivabene

; Munhoz, Derli Conceição

; Kraychete, Durval Campos

; Avelar, Esthael Cristina Querido

; Fukushima, Fernanda Bono

; Garcia, João Batista Santos

; Torres, João Nathanael Lima

; Rodrigues, Karenthan de Abreu

; Palladini, Mariana

; Chacon Neto, Olympio de Hollanda

; Carmona, Maria José Carvalho

Brazilian Journal of Anesthesiology

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2024, Volume 74 Nº 4 elocation 844513

Resumo: En | Texto: En | PDF: En

Abstract There is growing interest in using cannabinoids across various clinical scenarios, including pain medicine, leading to the disregard of regulatory protocols in some countries. Legislation has been implemented in Brazil, specifically in the state of São Paulo, permitting the distribution of cannabinoid products by health authorities for clinical purposes, free of charge for patients, upon professional prescription. Thus, it is imperative to assess the existing evidence regarding the efficacy and safety of these products in pain management. In light of this, the São Paulo State Society of Anesthesiology (SAESP) established a task force to conduct a narrative review on the topic using the Delphi method, requiring a minimum agreement of 60% among panelists. The study concluded that cannabinoid products could potentially serve as adjuncts in pain management but stressed the importance of judicious prescription. Nevertheless, this review advises against their use for acute pain and cancer-related pain. In other clinical scenarios, established treatments should take precedence, particularly when clinical protocols are available, such as in neuropathic pain. Only patients exhibiting poor therapeutic responses to established protocols or demonstrating intolerance to recommended management may be considered as potential candidates for cannabinoids, which should be prescribed by physicians experienced in handling these substances. Special attention should be given to individual patient characteristics and the likelihood of drug interactions. scenarios medicine countries Brazil purposes prescription Thus SAESP (SAESP method 60 panelists Nevertheless cancerrelated cancer related precedence available substances interactions 6

https://doi.org/10.1016/j.bjane.2024.844513

To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis B B2 positive outcomes
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Resende, Gustavo Gomes

; Saad, Carla Goncalves Schahin

; Marques, Claudia Diniz Lopes

; Ribeiro, Sandra Lúcia Euzébio

; Gavi, Maria Bernadete Renoldi de Oliveira

; Yazbek, Michel Alexandre

; Marinho, Adriana de Oliveira

; Menin, Rita de Cássia

; Ochtrop, Manuella Lima Gomes

; Soares, Andressa Miozzo

; Cavalcanti, Nara Gualberto

; Carneiro, Jamille Nascimento

; Werner de Castro, Glaucio Ricardo

; Fernandes, José Mauro Carneiro

; Souza, Elziane da Cruz Ribeiro E

; Alvarenga, Corina Quental de Menezes

; Vieira, Rejane Maria Rodrigues de Abreu

; Machado, Natalia Pereira

; Ximenes, Antônio Carlos

; Gazzeta, Morgana Ohira

; Albuquerque, Cleandro Pires de

; Skare, Thelma Larocca

; Keiserman, Mauro Waldemar

; Kohem, Charles Lubianca

; Benacon, Gabriel Sarkis

; Rocha, Vítor Florêncio Santos

; Lage, Ricardo da Cruz

; Malheiro, Olivio Brito

; Golebiovski, Rywka Tenenbaum Medeiros

; Oliveira, Thauana Luiza

; Duque, Ruben Horst

; Londe, Ana Carolina

; Pinheiro, Marcelo de Medeiros

; Sampaio-Barros, Percival Degrava

Advances in Rheumatology

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2024, Volume 64 elocation 33

Resumo: En | Texto: En | PDF: En

Abstract Background There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population. HLAB27 HLAB HLA B27 B HLA-B2 SpA, , (SpA) worldwide However mixedrace mixed race populations RBE. . (RBE) multicenter observational 4 Brazil follow 1 (1 rheumatologist 2 (2 18 ≥1 years 3 (3 axial protocol historical 109 included 734 73 73.4 444 44 44. ±13.2 132 13 (±13.2 uveitis Conversely psoriasis activity mobility world Furthermore HLAB2 B2 HLA-B (SpA (RBE ( ≥ 10 7 73. ±13. (±13. ±13 (±13 ±1 (±1 ± (±

https://doi.org/10.1186/s42358-024-00372-0

Investigating the safety of antibiotics added to collared peccary (Pecari tajacu) semen extender through a multiparametric thermoresistance test Pecari tajacu
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Santos, Caio Sérgio

; Cavalcante, Yasmim Carla da Silva

; Campos, Lívia Batista

; Silva, Andréia Maria da

; Feijó, Francisco Marlon Carneiro

; Silva, Alexandre Rodrigues

Animal Reproduction

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2024, Volume 21 Nº 3 elocation e20240018

Resumo: En | Texto: En | PDF: En

Abstract The effects of antibiotics on sperm longevity in collared peccary (Pecari tajacu) fresh diluted semen was evaluated. Semen samples from six adult males were collected by electroejaculation and diluted in Tris-citrate-fructose alone (control) and plus streptomycin-penicillin (2 mg/ml-2000 IU/ml) or gentamicin (70 µg/ml). Membrane integrity and functionality, mitochondrial activity and sperm morphology were assessed subjectively. Sperm motility and other kinetic parameters were objectively assessed using CASA (computer-assisted semen analysis). The semen diluted according to the treatments were submitted to the thermoresistance test, incubated at 37 ° C, and the sperm parameters analyzed at 0, 30, 60, 120 and 180 min. The average values of the treatments were compared with each other and between the times. There were no differences (P > 0.05) between treatments until the end of the test. Control and streptomycin-penicillin samples maintained sperm function for up to 180 min (with total motility of 24.3 ± 7.1% and 28 ± 8.7%, respectively). Gentamicin aliquots retained most parameters until the end of the incubation, except for membrane integrity and mitochondrial activity that declined (P < 0.05) at 180 min (53.1 ± 7.1% and 50.7 ± 6.2%, respectively) compared to 0 min (80.5 ± 4.7% and 86.3 ± 3.4%, respectively). In conclusion, a multiparametric thermoresistance test proved that Tris-based extenders used for collared peccary semen can be effectively supplemented by streptomycin-penicillin (2 mg/ml-2000 IU/ml) or gentamicin (70 µg/ml), especially during 180-min incubation at 37 °C. Pecari tajacu evaluated Triscitratefructose Tris citrate fructose control (control streptomycinpenicillin streptomycin penicillin 2 ( mg/ml2000 mgml2000 mgml mg/ml 2000 mg ml mg/ml-200 IU/ml IUml IU 70 (7 µg/ml. µgml µg/ml . µg µg/ml) functionality subjectively computerassisted computer assisted analysis. analysis analysis) 3 C 30 60 12 18 times P 0.05 005 05 243 24 24. 71 7 1 7.1 87 8 8.7% respectively. respectively 53.1 531 53 (53. 507 50 50. 62 6 6.2% 80.5 805 80 5 (80. 47 4 4.7 863 86 86. 34 3.4% conclusion Trisbased based µg/ml, , 180min °C ml2000 mg/ml200 mgml200 200 mg/ml-20 0.0 00 7. 8.7 53. (53 6.2 80. (80 4. 3.4 ml200 mg/ml20 mgml20 20 mg/ml-2 0. 8. (5 6. (8 3. ml20 mg/ml2 mgml2 mg/ml- ml2

https://doi.org/10.1590/1984-3143-ar2024-0018

10.

Occurrence of avian reovirus and picobirnavirus in wild birds from an environmental protection area in the Brazilian Amazon
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PEREIRA, Diego

; SOUTO, Lizandra Caroline dos Santos

; GUERRA, Sylvia de Fátima dos Santos

; PENHA-JÚNIOR, Edvaldo Tavares da

; LOBO, Patrícia dos Santos

; SOARES, Luana da Silva

; PINHEIRO, Helder Henrique Costa

; CHAGAS, Elaine Hellen Nunes

; GUIMARÃES, Ricardo José de Paula Souza e

; RAMOS, Bruna Alves

; CHAGAS, Liliane Leal das

; FREITAS, Maria Nazaré Oliveira

; FURTADO, Erilene Cristina da Silva

; RODRIGUES, Jéssica Cecília Pinheiro

; CASSEB, Alexandre do Rosário

; MARTINS, Lívia Caricio

; MASCARENHAS, Joana D’Arc Pereira

Acta Amazonica

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2024, Volume 54 Nº 1 elocation e54hs23012

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Wild birds have great prominence in the transmission of diseases to humans, mainly due to their ease of access to human populations, raising concerns about the potential impact of that proximity on public health. The present study reports ARV and PBV occurrence in wild birds from an environmental protection area in the Amazon biome, in Pará state, Brazil. We obtained 155 fecal specimens from 47 species of wild birds for RNA extraction, ARV and PBV detection utilizing molecular methods, nucleotide sequencing, and phylogenetic analysis. ARV prevalence was 0.6% (1/155), being positive in an individual of Myrmotherula longipennis, and PBV prevalence was 1.29% (2/155), affecting two individuals of Guira guira. The PBV strains were assigned to genogroup I based on phylogenetic analysis, and they shared a strong phylogenetic link with strains isolated from different geographic locations. The ARV strain was more closely related to strains that had previously circulated in the same region. The presence of ARV and PBV in this habitat suggests that infection cycles of these agents occur naturally in the wild ecosystem, potentially triggering transmission events between bird species and humans. This is the first study on ARV detection in wild birds in Brazil and the first report on the occurrence of PBV in wild Guira guira. Additional studies are required to determine the epidemiology, origin, evolution, and emergence of new potentially pathogenic viruses in the Amazon. humans populations health biome state 15 4 extraction methods sequencing analysis 06 0 6 0.6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1.29 2/155, 2155 2/155 2 (2/155) guira locations region ecosystem epidemiology origin evolution 0. 115 1/15 (1/155 12 1.2 215 2/15 (2/155 11 1/1 (1/15 1. 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

RESUMO As aves silvestres têm grande destaque na transmissão de doenças ao homem, principalmente pela facilidade de acesso à população humana, levantando preocupações sobre o potencial impacto dessa proximidade no contexto da saúde pública. O presente estudo relata a ocorrência de ARV e PBV em aves silvestres de uma área de proteção ambiental no bioma Amazônico. Obtivemos 155 espécimes fecais de 47 espécies de aves silvestres, que foram submetidos a extração de RNA, detecção de ARV e PBV por técnicas moleculares, sequenciamento nucleotídico e análise filogenética. A prevalência de infecção por ARV foi 0,6% (1/155), sendo positivo em um indivíduo de Myrmotherula longipennis, e a prevalência de PBV foi 1,29% (2/155), afetando dois insdivíduos de Guira guira. A análise filogenética agrupou as cepas de PBV no genogrupo I, mostrando intensa relação filogenética com cepas isoladas de outras regiões geográficas. A cepa de ARV esteve mais relacionada filogeneticamente a cepas previamente circulantes na mesma região. Este é o primeiro estudo sobre detecção de ARV em aves silvestres no Brasil e o primeiro relato sobre a ocorrência de PBV em Guira guira. A circulação de ARV e PBV nesse ambiente demonstra que os ciclos desses agentes estão ocorrendo de forma natural no ecossistema silvestre, o que pode desencadear possíveis eventos de transmissão entre as espécies aviárias e humanos. Estudos adicionais são necessários para determinar a epidemiologia, origem, evolução e surgimento de novos vírus potencialmente patogênicos na Amazônia. homem humana pública Amazônico 15 4 RNA moleculares 06 0 6 0,6 1/155, 1155 1/155 , 1 (1/155) longipennis 129 29 1,29 2/155, 2155 2/155 2 (2/155) guira I geográficas região silvestre humanos epidemiologia origem Amazônia 0, 115 1/15 (1/155 12 1,2 215 2/15 (2/155 11 1/1 (1/15 1, 21 2/1 (2/15 1/ (1/1 2/ (2/1 (1/ (2/ (1 (2 (

https://doi.org/10.1590/1809-4392202300120

11.

Randomized crossover clinical trial of a Mindfulness-based intervention for nurse leaders: A pilot study Mindfulnessbased Mindfulness based leaders
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Santos, Teresa Maria dos

; Balsanelli, Alexandre Pazetto

; Souza, Káren Mendes Jorge de

Revista Latino-Americana de Enfermagem

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2024, Volume 32 elocation e4101

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Objetivo: analizar los efectos de una intervención basada en mindfulness sobre la inteligencia emocional y la resiliencia de enfermeros líderes. Método: estudio piloto de un ensayo clínico aleatorizado cruzado. Muestra (n=32) aleatorizada en el grupo A (n=18) y grupo B (n=14), se los evaluó en el pretest, postest y seguimiento. Los resultados fueron evaluados mediante la Medida de Inteligencia Emocional, el Cuestionario de Resiliencia de Connor-Davidson y el Cuestionario Mindfulness de Cinco Facetas, y analizados por el Generalized Linear Mixed Models . Resultados: fueron evaluadas 32 enfermeras con una edad promedio de 42,6 años. Los análisis mostraron interacciones significativas de los efectos de los factores grupo vs. momento en los puntajes de las habilidades de automotivación (p=0,005), sociabilidad (p<0,001), autocontrol (p=0,013) y total (p=0,002) de inteligencia emocional; de las facetas observar (p=0,042), describir (p=0,008), no juzgar (p<0,001), actuar con conciencia (p=0,004) y total (p<0,001) de mindfulness. Postest: hubo un aumento estadísticamente significativo de las habilidades de sociabilidad (p=0,009) y autocontrol (p=0,015) de inteligencia emocional; de las facetas no juzgar (p=0,022) y total (p=0,002) de mindfulness . Seguimiento: se observó un aumento significativo en las facetas no juzgar (p=0,024) y total (p=0,026) de mindfulness . La variable resiliencia no presentó significación estadística en el factor grupo vs. momento en el postest y seguimiento. Conclusión: la intervención basada en mindfulness utilizada demostró ser eficaz para aumentar la inteligencia emocional y las habilidades de mindfulness disposicional de los enfermeros líderes. Registro Brasileño de Ensayos Clínicos (RBR-3c62gy), registrado el 4 de marzo de 2020, actualizado el 16 de septiembre de 2022. Objetivo líderes Método cruzado n=32 n32 n (n=32 n=18 n18 18 (n=18 n=14, n14 n=14 , 14 (n=14) pretest seguimiento Emocional ConnorDavidson Connor Davidson Facetas Resultados 3 426 42 6 42, años vs p=0,005, p0005 p p=0,005 0 005 (p=0,005) p<0,001, p0001 p<0,001 001 p=0,013 p0013 013 (p=0,013 p=0,002 p0002 002 (p=0,002 p=0,042, p0042 p=0,042 042 (p=0,042) p=0,008, p0008 p=0,008 008 (p=0,008) p=0,004 p0004 004 (p=0,004 (p<0,001 Postest p=0,009 p0009 009 (p=0,009 p=0,015 p0015 015 (p=0,015 p=0,022 p0022 022 (p=0,022 Seguimiento p=0,024 p0024 024 (p=0,024 p=0,026 p0026 026 (p=0,026 Conclusión RBR3c62gy, RBR3c62gy RBRcgy RBR 3c62gy c gy (RBR-3c62gy) 2020 1 2022 n=3 n3 (n=3 n=1 n1 (n=1 (n=14 p000 p=0,00 00 (p=0,005 p<0,00 p=0,01 p001 01 (p=0,01 (p=0,00 p004 p=0,04 04 (p=0,042 (p=0,008 (p<0,00 p=0,02 p002 02 (p=0,02 cgy (RBR-3c62gy 202 n= (n= p00 p=0,0 p<0,0 (p=0,0 (p=0,04 (p<0,0 20 (n p0 p=0, p<0, (p=0, (p<0, 2 p=0 p<0 (p=0 (p<0 p= p< (p= (p< (p

Objective: to analyze the effects of a Mindfulness-based intervention on nurse leaders’ emotional intelligence and resilience. Method: a pilot study of a randomized crossover clinical trial. The sample (n=32) was randomized into Group A (n=18) and Group B (n=14) and evaluated at the pre-test, post-test and follow-up moments. The outcomes were assessed using the Emotional Intelligence Measure, the Connor-Davidson Resilience Questionnaire and the Five Facet Mindfulness Questionnaire, and analyzed using Generalized Linear Mixed Models. Results: a total of 32 nurses with a mean age of 42.6 years old were evaluated. The analyses showed significant interactions between the effects of the group x moment factors on the Self-motivation (p=0.005), Sociability (p<0.001), Self-control (p=0.013), and Total (p=0.002) emotional intelligence skill scores; as well as on the Observe (p=0.042), Describe (p=0.008), Non-judgment (p<0.001), Act with awareness (p=0.004) and Total (p<0.001) mindfulness facets. Post-test: there was a statistically significant increase in the Sociability (p=0.009) and Self-control (p=0.015) emotional intelligence skills; as well as in the Non-judgment (p=0.022) and Total (p=0.002) mindfulness facets. Follow-up: a significant increase was observed in the Non-judgment (p=0.024) and Total (p=0.026) mindfulness facets. The “resilience” variable did not present statistical significance in the “group x moment” factor, both in the post-test and during follow-up. Conclusion: the Mindfulness-based intervention used proved to be effective in increasing nurse leaders’ emotional intelligence and dispositional mindfulness skills. Brazilian Registry of Clinical Trials (RBR-3c62gy), registered on March 4 th , 2020, updated on September 16 th , 2022. Objective Mindfulnessbased based leaders resilience Method trial n=32 n32 n (n=32 n=18 n18 18 (n=18 n=14 n14 14 (n=14 pretest, pretest pre test, test pre-test posttest post followup follow up moments Measure ConnorDavidson Connor Davidson Models Results 3 426 42 6 42. Selfmotivation Self motivation p=0.005, p0005 p p=0.005 0 005 (p=0.005) p<0.001, p0001 p<0.001 001 Selfcontrol control p=0.013, p0013 p=0.013 013 (p=0.013) p=0.002 p0002 002 (p=0.002 scores p=0.042, p0042 p=0.042 042 (p=0.042) p=0.008, p0008 p=0.008 008 (p=0.008) Nonjudgment Non judgment p=0.004 p0004 004 (p=0.004 (p<0.001 facets Posttest Post Post-test p=0.009 p0009 009 (p=0.009 p=0.015 p0015 015 (p=0.015 skills p=0.022 p0022 022 (p=0.022 Followup Follow Follow-up p=0.024 p0024 024 (p=0.024 p=0.026 p0026 026 (p=0.026 “resilience factor followup. up. Conclusion RBR3c62gy, RBR3c62gy RBRcgy RBR 3c62gy c gy (RBR-3c62gy) 2020 1 2022 n=3 n3 (n=3 n=1 n1 (n=1 p000 p=0.00 00 (p=0.005 p<0.00 p001 p=0.01 01 (p=0.013 (p=0.00 p004 p=0.04 04 (p=0.042 (p=0.008 (p<0.00 (p=0.01 p=0.02 p002 02 (p=0.02 cgy (RBR-3c62gy 202 n= (n= p00 p=0.0 p<0.0 (p=0.0 (p=0.04 (p<0.0 20 (n p0 p=0. p<0. (p=0. (p<0. 2 p=0 p<0 (p=0 (p<0 p= p< (p= (p< (p

Objetivo: analisar os efeitos de uma intervenção baseada em mindfulness na inteligência emocional e resiliência de enfermeiros líderes. Método: estudo-piloto de ensaio clínico randomizado cruzado. Amostra (n=32) randomizada em grupo A (n=18) e grupo B (n=14), avaliados nos momentos pré-teste, pós-teste e seguimento. Os desfechos foram avaliados pela Medida de Inteligência Emocional, pelo Questionário de Resiliência Connor-Davidson e pelo Questionário das Cinco Facetas de Mindfulness , e analisados pelo Generalized Linear Mixed Model . Resultados: foram avaliadas 32 enfermeiras com idade média de 42,6 anos. As análises mostraram interações significativas dos efeitos dos fatores Grupo x Momento nos escores das habilidades de automotivação (p=0,005), sociabilidade (p<0,001), autocontrole (p=0,013) e total (p=0,002) de inteligência emocional; das facetas observar (p=0,042), descrever (p=0,008), não julgar (p<0,001), agir com consciência (p=0,004) e total (p<0,001) de mindfulness . Pós-teste: houve aumento estatisticamente significante das habilidades de sociabilidade (p=0,009) e autocontrole (p=0,015) de inteligência emocional; das facetas não julgar (p=0,022) e total (p=0,002) de mindfulness . Seguimento: observou-se aumento significativo das facetas não julgar (p=0,024) e total (p=0,026) de mindfulness . A variável resiliência não apresentou significância estatística no fator Grupo x Momento, no pós-teste e seguimento. Conclusão: a intervenção baseada em mindfulness utilizada mostrou-se efetiva no aumento das habilidades de inteligência emocional e mindfulness disposicional de enfermeiros líderes. Registro Brasileiro de Ensaios Clínicos (RBR-3c62gy), registrado em 04 de março de 2020, atualizado em 16 de setembro de 2022. Objetivo líderes Método estudopiloto estudo piloto cruzado n=32 n32 n (n=32 n=18 n18 18 (n=18 n=14, n14 n=14 14 (n=14) préteste, préteste pré teste, teste pré-teste pósteste pós seguimento Emocional ConnorDavidson Connor Davidson Resultados 3 426 42 6 42, anos p=0,005, p0005 p p=0,005 0 005 (p=0,005) p<0,001, p0001 p<0,001 001 p=0,013 p0013 013 (p=0,013 p=0,002 p0002 002 (p=0,002 p=0,042, p0042 p=0,042 042 (p=0,042) p=0,008, p0008 p=0,008 008 (p=0,008) p=0,004 p0004 004 (p=0,004 (p<0,001 Pósteste Pós Pós-teste p=0,009 p0009 009 (p=0,009 p=0,015 p0015 015 (p=0,015 p=0,022 p0022 022 (p=0,022 Seguimento observouse observou se p=0,024 p0024 024 (p=0,024 p=0,026 p0026 026 (p=0,026 Conclusão mostrouse mostrou RBR3c62gy, RBR3c62gy RBRcgy RBR 3c62gy c gy (RBR-3c62gy) 2020 1 2022 n=3 n3 (n=3 n=1 n1 (n=1 (n=14 4 p000 p=0,00 00 (p=0,005 p<0,00 p=0,01 p001 01 (p=0,01 (p=0,00 p004 p=0,04 (p=0,042 (p=0,008 (p<0,00 p=0,02 p002 02 (p=0,02 cgy (RBR-3c62gy 202 n= (n= p00 p=0,0 p<0,0 (p=0,0 (p=0,04 (p<0,0 20 (n p0 p=0, p<0, (p=0, (p<0, 2 p=0 p<0 (p=0 (p<0 p= p< (p= (p< (p

https://doi.org/10.1590/1518-8345.6548.4101

12.

Estudos em Aspidosperma Mart. & Zucc. (Apocynaceae): Integrando morfologia e filogenia Mart Zucc Apocynaceae (Apocynaceae) (Apocynaceae
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Teixeira, Carlos Alexandre dos Santos

; Castello, Ana Carolina Devides

; Pereira, Andreza Stephanie de Souza

; Farinaccio, Maria Ana

Hoehnea

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2024, Volume 51 elocation e812023

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Um dos gêneros mais importantes de Apocynaceae, Aspidosperma apresenta desafios na delimitação de espécies devido à sobreposição de caracteres morfológicos e o grande número de sinonímias. Assim, buscamos entender os caracteres morfológicos mais relevantes na delimitação de duas seções do gênero (Aspidosperma sect. Aspidosperma e A. sect. Pungentia), confrontando hipóteses de homologia primária com estudo filogenético molecular. Os dados dos caracteres foram obtidos através da literatura do gênero e confrontados em uma árvore filogenética para verificar a presença de características diagnósticas para as seções e espécies. Nossos resultados evidenciaram: (1) a confirmação de características diagnósticas para as duas seções; (2) a possibilidade de segregar a seção típica em três novas seções, com base nas características morfológicas; (3) a distinção de espécies tradicionalmente tratadas como sinônimos; (4) a importância da utilização de características da madeira para a delimitação de gêneros com ampla variação morfológica, como é o caso de Aspidosperma. Apocynaceae sinonímias Assim sect A Pungentia, Pungentia , Pungentia) molecular evidenciaram 1 (1 2 (2 morfológicas 3 (3 sinônimos 4 (4 morfológica (

ABSTRACT One of the most important genera of Apocynaceae, Aspidosperma presents challenges in species delimitation due to overlapping morphological characters and the large number of synonyms. Thus, we seek to understand the most relevant morphological characters in the delimitation of two sections of the genus (Aspidosperma sect. Aspidosperma and A. sect. Pungentia), confronting hypotheses of primary homology with a molecular phylogenetic study. Character data were obtained from the literature of the genus and confronted in a phylogenetic tree to verify the presence of diagnostic characteristics for sections and species. Our results showed: (1) confirmation of diagnostic characteristics for both sections; (2) the possibility of segregating the typical section into three new sections based on morphological characteristics; (3) the distinction of species traditionally treated as synonyms; (4) the importance of using wood characteristics for the delimitation of genera with wide morphological variation, as is the case of Aspidosperma. Apocynaceae synonyms Thus sect A Pungentia, Pungentia , Pungentia) study showed 1 (1 2 (2 3 (3 4 (4 variation (

https://doi.org/10.1590/2236-8906e812023

13.

Biological evaluation of critical bone defect regeneration using hydroxyapatite/ alginate composite granules hydroxyapatite
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Ribeiro, Iorrana Índira dos Anjos

; Almeida, Renata dos Santos

; Silva, Ana Maria Guerreiro Braga da

; Barbosa Júnior, Aryon de Almeida

; Rossi, Alexandre Malta

; Miguel, Fúlvio Borges

; Rosa, Fabiana Paim

Acta Cirúrgica Brasileira

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2024, Volume 39 elocation e392824

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: to evaluate biocompatibility and osteogenic potential of hydroxyapatite/alginate composite after its implantation on rat calvarian critical bone defect. Methods: thirty adults male Wistar rats were randomly distributed into two groups: GHA – critical bone defect filled with hydroxyapatite/alginate composite granules (HA/Alg) and CG – critical bone defect without biomaterial; evaluated at biological points of 15, 45 and 120 days. Results: the histomorphometrically analyses for GHA showed osteoid matrix deposition (OM) among the granules and towards the center of the defect in centripetal direction throughout the study, with evident new bone formation at 120 days, resulting in filling 4/5 of the initial bone defect. For CG, this finding was restricted to the edges of the bone margins and formation of connective tissue on the residual area was found in all biological points. Inflammatory response on GHA was chronic granulomatous type, discrete and regressive for all biological points. Throughout the study, the CG presented mononuclear inflammatory infiltrate diffuse and regressive. Histomorphometry analyses showed that OM percentage was evident for GHA group when compared to CG group in all analyzed periods (p > 0.05). Conclusions: the biomaterial evaluated at this study showed to be biocompatible, bioactive, osteoconductive and biodegradable synchronously with bone formation. Purpose hydroxyapatitealginate hydroxyapatite alginate Methods groups HA/Alg HAAlg HA Alg (HA/Alg 15 4 12 days Results (OM 5 4/ type p 0.05. 005 0.05 . 0 05 0.05) Conclusions biocompatible bioactive 1 00 0.0 0.

https://doi.org/10.1590/acb392824

14.

Allozyme and cytogenetic analysis in two species of Hypostomus (Siluriformes: Loricariidae) from the Paraguai River basin, Brazil: occurrence of B microchromosome and intrapopulation heterochromatic polymorphism in H. boulengeri Siluriformes (Siluriformes Loricariidae basin Brazil H
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Paiva, Suzana de

; Porto, Fernanda Errero

; Codognotto, Flávio José

; Fernandes, Carlos Alexandre

; Rossi, Margarida Maria Vieira

; Borin-Carvalho, Luciana Andreia

; Portela-Castro, Ana Luiza de Brito

; Zawadzki, Claudio Henrique

; Renesto, Erasmo

; Martins-Santos, Isabel Cristina

Neotropical Ichthyology

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2024, Volume 22 Nº 2 elocation e230117

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Hypostomus está distribuído por bacias da América Central e do Sul, com grande diversidade de espécies com conflitos taxonômicos. Desta forma, a integração de técnicas auxiliares contribui para a compreensão da sistemática e filogenia do grupo. Assim, este estudo teve como objetivo investigar Hypostomus cochliodon e H. boulengeri do riacho Onça (bacia do rio Paraguai) por meio de técnicas aloenzimáticas e citogenéticas. As análises citogenéticas em H. boulengeri mostraram número cromossômico igual a 2n = 68 (14m+14sm+18st+22a), sistema de NOR múltiplo revelado por Ag-NOR e 18S-FISH, um polimorfismo de heterocromatina em acrocêntricos e a presença de microcromossomos Bs. Hypostomus cochliodon mostrou um número diploide de 64 cromossomos (16m+26sm+14st+8a); apesar do sistema de NOR simples, alguns indivíduos apresentaram NOR em ambos os telômeros detectados por Ag-NOR e 18S-FISH. Uma isozima identificou dois loci diagnósticos (Idh-A and Gdh-A) entre as duas espécies e múltiplos loci com alelos únicos em H. boulengeri. A variabilidade genética indicada pela heterozigosidade média (He) foi de 0,2461 e 0,0309 em H. boulengeri e H. cochliodon, respectivamente. Assim, este estudo relata os primeiros dados citogenéticos para H. boulengeri e os primeiros dados isoenzimáticos para H. boulengeri e H. cochliodon. As duas espécies apresentaram evidentes diferenças citogenéticas e isoenzimáticas com a obtenção de marcadores genéticos exclusivos fornecendo suporte para futuros estudos evolutivos no grupo. Sul taxonômicos forma grupo Assim H bacia Paraguai n 6 14m+14sm+18st+22a, 14m14sm18st22a msmsta 14m+14sm+18st+22a , 14m 14sm 18st 22a m sm st (14m+14sm+18st+22a) AgNOR Ag 18SFISH, 18SFISH SFISH 18S FISH, FISH S 18S-FISH Bs 16m+26sm+14st+8a 16m26sm14st8a 16m 26sm 14st 8a (16m+26sm+14st+8a) simples 18SFISH. FISH. IdhA Idh GdhA Gdh Gdh-A He (He 02461 0 2461 0,246 00309 0309 0,030 respectivamente (14m+14sm+18st+22a (16m+26sm+14st+8a 0246 246 0,24 0030 030 0,03 024 24 0,2 003 03 0,0 02 2 0, 00

Abstract Hypostomus is distributed by Central and South America basins, with diverse species with taxonomic conflicts. This way, the integration of auxiliary techniques contributes to understanding the systematics and phylogeny of the group. Thus, this study aimed to investigate the Hypostomus cochliodon and H. boulengeri from the Onça stream (Paraguai River basin) by allozyme and cytogenetic techniques. Hypostomus boulengeri showed a diploid number of 68 chromosomes (14m+14sm+18st+22a), multiple NOR revealed by Ag-NOR and 18S rDNA FISH, a polymorphism of heterochromatin in acrocentrics and the presence of B microchromosome. Hypostomus cochliodon showed a diploid number of 64 chromosomes (16m+26sm+14st+8a); despite the single NOR, some individuals showed NOR in both telomeres detected by Ag-NOR and 18S rDNA FISH. Isozyme identified two diagnostic loci (Idh-A and Gdh-A) between the two species and multiple loci with unique alleles in H. boulengeri. The genetic variability indicated by the mean heterozygosity (He) was 0.2461 and 0.0309 in H. boulengeri and H. cochliodon,respectively.Thus, this study reports the first cytogenetic data for H. boulengeri and the first isozymatic data for H. boulengeri and H. cochliodon. The two species presented evident cytogenetic and isoenzymatic differences with the obtaining of exclusive genetic markers providing support for future evolutionary studies in the group. basins conflicts way group Thus H Paraguai basin 6 14m+14sm+18st+22a, 14m14sm18st22a msmsta 14m+14sm+18st+22a , 14m 14sm 18st 22a m sm st (14m+14sm+18st+22a) AgNOR Ag S FISH microchromosome 16m+26sm+14st+8a 16m26sm14st8a 16m 26sm 14st 8a (16m+26sm+14st+8a) IdhA Idh A GdhA Gdh Gdh-A He (He 02461 0 2461 0.246 00309 0309 0.030 cochliodonrespectivelyThus respectively cochliodon,respectively.Thus (14m+14sm+18st+22a (16m+26sm+14st+8a 0246 246 0.24 0030 030 0.03 024 24 0.2 003 03 0.0 02 2 0. 00

https://doi.org/10.1590/1982-0224-2023-0117

15.

Characterization of the patterns of care, access, and direct cost of systemic lupus erythematosus in Brazil: findings from the Macunaíma study care access Brazil
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de Abreu, Mirhelen Mendes

; Monticielo, Odirlei Andre

; Fernandes, Vander

; Rodrigues, Dalianna Luise Andrade Souto

; da Silva, Cristhiane Almeida Leite

; Maiorano, Alexandre Cristovão

; Beserra, Fernando dos Santos

; Lamarão, Flavia Rachel Moreira

; de Veras, Bruna Medeiros Gonçalves

; David, Nathalie

; Araújo, Magda

; Alves, Marcelly Cristinny Ribeiro

; Stocco, Matheus Amaral

; Lima, Fernando Mello

; Borret, Emilly

; Gasparin, Andrese Aline

; Chapacais, Gustavo Flores

; Bulbol, Guilherme Andrade

; Lima, Diogo da Silva

; da Silva, Natália Jardim Martins

; Freitas, Marta Maria Costa

; Bica, Blanca Elena Rios Gomes

; de Lima, Domingos Sávio Nunes

; Medeiros, Marta Maria das Chagas

Advances in Rheumatology

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2024, Volume 64 elocation 30

Resumo: En | Texto: En | PDF: En

Abstract Background A cost of illness (COI) study aims to evaluate the socioeconomic burden that an illness imposes on society as a whole. This study aimed to describe the resources used, patterns of care, direct cost, and loss of productivity due to systemic lupus erythematosus (SLE) in Brazil. Methods This 12-month, cross-sectional, COI study of patients with SLE (ACR 1997 Classification Criteria) collected data using patient interviews (questionnaires) and medical records, covering: SLE profile, resources used, morbidities, quality of life (12-Item Short Form Survey, SF-12), and loss of productivity. Patients were excluded if they were retired or on sick leave for another illness. Direct resources included health-related (consultations, tests, medications, hospitalization) or non-health-related (transportation, home adaptation, expenditure on caregivers) hospital resources. Costs were calculated using the unit value of each resource and the quantity consumed. A gamma regression model explored cost predictors for patients with SLE. Results Overall, 300 patients with SLE were included (92.3% female, mean [standard deviation (SD)] disease duration 11.8 [7.9] years), of which 100 patients (33.3%) were on SLE-related sick leave and 46 patients (15.3%) had stopped schooling. Mean (SD) travel time from home to a care facility was 4.4 (12.6) hours. Antimalarials were the most commonly used drugs (222 [74.0%]). A negative correlation was observed between SF-12 physical component and SLE Disease Activity Index (- 0.117, p = 0.042), Systemic Lupus International CollaboratingClinics/AmericanCollegeofRheumatology Damage Index (- 0.115, p = 0.046), medications/day for multiple co-morbidities (- 0.272, p < 0.001), SLE-specific drugs/day (- 0.113, p = 0.051), and lost productivity (- 0.570, p < 0.001). For the mental component, a negative correlation was observed with medications/day for multiple co-morbidities (- 0.272, p < 0.001), SLE-specific medications/day (- 0.113, p = 0.051), and missed appointments (- 0.232, p < 0.001). Mean total SLE cost was US$3,123.53/patient/year (median [interquartile range (IQR)] US$1,618.51 [$678.66, $4,601.29]). Main expenditure was medication, with a median (IQR) cost of US$910.62 ($460, $4,033.51). Mycophenolate increased costs by 3.664 times (p < 0.001), and inflammatory monitoring (erythrocyte sedimentation rate or C-reactive protein) reduced expenditure by 0.381 times (p < 0.001). Conclusion These results allowed access to care patterns, the median cost for patients with SLE in Brazil, and the differences across regions driven by biological, social, and behavioral factors. The cost of SLE provides an updated setting to support the decision-making process across the country. (COI whole (SLE Brazil 12month, 12month month 12 month, 12-month crosssectional, crosssectional cross sectional, sectional cross-sectional ACR 199 Criteria questionnaires (questionnaires records covering profile morbidities 12Item Item Survey SF12, SF12 SF , SF-12) healthrelated health related consultations, consultations (consultations tests medications hospitalization nonhealthrelated non transportation, transportation (transportation adaptation caregivers consumed Overall 30 92.3% 923 92 3 (92.3 female standard SD 118 11 8 11. 7.9 79 7 9 [7.9 years, years years) 10 33.3% 333 33 (33.3% SLErelated 4 15.3% 153 15 (15.3% schooling (SD 44 4. 12.6 126 6 (12.6 hours 222 (22 74.0%. 740 74.0% . 74 0 [74.0%]) SF-1 ( 0117 117 0.117 0.042, 0042 0.042 042 0.042) CollaboratingClinicsAmericanCollegeofRheumatology CollaboratingClinics AmericanCollegeofRheumatology 0115 115 0.115 0.046, 0046 0.046 046 0.046) medicationsday day comorbidities co 0272 272 0.272 0.001, 0001 0.001 001 0.001) SLEspecific specific drugsday 0113 113 0.113 0.051, 0051 0.051 051 0.051) 0570 570 0.570 0.001. 0232 232 0.232 US312353patientyear USpatientyear US 123 53 year interquartile IQR US161851 1 618 51 US$1,618.5 $678.66, 67866 678 66 [$678.66 $4,601.29. 460129 $4,601.29 601 29 $4,601.29]) medication (IQR US91062 910 62 US$910.6 $460, 460 ($460 $4,033.51. 403351 $4,033.51 033 $4,033.51) 3664 664 3.66 erythrocyte Creactive C reactive protein 0381 381 0.38 biological social factors decisionmaking decision making country 19 SF1 92.3 (92. 7. [7. 33.3 (33.3 15.3 (15.3 12. (12. 22 (2 74.0 [74.0%] SF- 011 0.11 004 0.04 04 027 27 0.27 000 0.00 00 005 0.05 05 057 57 0.57 023 23 0.23 patientyear 5 US16185 61 US$1,618. $678.66 6786 67 [$678.6 46012 $4,601.2 60 2 $4,601.29] US9106 91 US$910. $460 ($46 40335 $4,033.5 03 366 3.6 038 38 0.3 92. (92 [7 33. (33. 15. (15. (12 74. [74.0% 01 0.1 0.0 02 0.2 0.5 US1618 US$1,618 $678.6 [$678. 4601 $4,601. US910 US$910 $46 ($4 4033 $4,033. 36 3. 0. (9 [ (33 (15 (1 [74.0 US161 US$1,61 $678. [$678 $4,601 US91 US$91 $4 ($ 403 $4,033 (3 [74. US16 US$1,6 $678 [$67 $4,60 US9 US$9 $ 40 $4,03 [74 US1 US$1, $67 [$6 $4,6 US$ $4,0 US$1 $6 [$ $4,

https://doi.org/10.1186/s42358-024-00369-9

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