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INDICADORES ANTRÓPICOS: Estudo comparativo para a sustentabilidade na Amazônia ANTRÓPICOS
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FERNANDES, JOSÉ GUILHERME DOS SANTOS
; SANTOS, ADRIANO MADUREIRA DOS
; SERUFFO, MARCOS CÉSAR DA ROCHA
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ABSTRACT In contrast to the traditional view of anthropization as simple environmental degradation, Anthropic Indicators arise from the need to understand constructive or destructive human interventions. This study aims to present the Anthropic Indicators in their structure and application, corroborating their use in Amazonian communities. The results indicate strong human influence on the environment, highlighting the need for sustainable policies to balance human actions and preserve biodiversity. degradation interventions application communities environment biodiversity
RESUMO Em contraste com a visão tradicional da antropização como simples degradação ambiental, os Indicadores Antrópicos surgem da necessidade de entender as intervenções humanas construtivas ou destrutivas. Este estudo visa a apresentar os Indicadores Antrópicos em sua estrutura e aplicação, corroborados por seu uso em comunidades amazônicas. Os resultados indicam forte influência humana no meio ambiente, destacando a necessidade de políticas sustentáveis para equilibrar as ações humanas e preservar a biodiversidade. ambiental destrutivas aplicação amazônicas ambiente biodiversidade
2.
Meat quality of pigs fed grape pomace in different production systems
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GIULIANI, CAROLINE DOS SANTOS
; ROSADO JÚNIOR, ADRIANO G.
; MATEUS, ANA LÚCIA S.S.
; FONSECA, PATRÍCIA A.F DA
; FALK, RENATA B.
; THIEL, SUSLIN R.
; LEÃES, YASMIM S.V.
; EBLING, FABIANI DA ROCHA
; WAGNER, ROGER
; NÖRNBERG, JOSÉ LAERTE
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Anais da Academia Brasileira de Ciências
- Métricas do periódico
Abstract The main objective of this study was to evaluate the effects of supplementation the diet of pigs with grape pomace preserved in silage form (GPS) and its interaction with indoor and outdoor production systems, with and without access to vegetation, on the attributes of meat quality produced. Analyzes of proximal composition, cholesterol content, fatty acid profile, shear force, texture profile and sensory analysis were performed. During cold storage, oxidative stability and objective color were analyzed. Statistical analysis was performed in a 3x2 factorial design (production systems (S) x GPS-feed (F)) and the interaction between them (S*F). The results showed that there was no interaction between the production system and GPS feeding for the attributes evaluated. The proximate composition and fatty acid profile of the muscle remained unchanged. Additionally, it provides higher subjective and objective tenderness, higher red color intensity, and reduces lipid oxidation under refrigeration. The supplementation of pig feed with GPS improve the quality of the meat and constitute a sustainable alternative for the winemaking residue. (GPS vegetation produced content force storage analyzed 3x S (S GPSfeed F (F) S*F. SF S*F . (S*F) evaluated unchanged Additionally tenderness intensity refrigeration residue (F (S*F
3.
Photodynamic therapy repairs medication-related osteonecrosis of the jaw by reducing NF-kB protein in rats medicationrelated medication related NFkB NF kB
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PONTES, Jannerson Cesar Xavier de
; FIGUEIREDO, Ludmila Silva de
; LIMA, Wilson José de Miranda
; ARAÚJO, Rubens da Silva
; SANTOS, Ana Beatriz Rodrigues dos
; ALMEIDA, Leopoldina de Fátima Dantas de
; ALVES, Adriano Francisco
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Abstract Objective To evaluate whether antimicrobial photodynamic therapy (aPDT) repairs bisphosphonate-related osteonecrosis of the jaw (BRONJ) modulated by the reduction of NF-kB protein in a murine model. Methodology Male Wistar rats (N=30) were divided into the following groups (n=6/group): negative control (NC); experimental osteonecrosis (ONE); ONE + photosensitizer (PS); ONE + photobiomodulation (PBM); and ONE + aPDT. Over 8 weeks, ONE was induced by zoledronic acid 250 µg/kg injections, except in the NC group, which received sterile 0.9% saline, followed by extraction of the lower left first molar. Red light laser irradiation (wavelength ~660 nm, power 50 mW, energy of 2 J, energy dose of 66.67 J/cm2 for 40 s) was performed once a week for 4 weeks. Methylene blue 0.3% was used as PS. The animals were euthanized and examined macroscopically for the presence of exposed bone and epithelial repair and microscopically by histochemical (hematoxylin-eosin and Masson’s trichrome staining) and immunohistochemical (anti-NF-kB) methods. Macroscopic and histomorphometric data were analyzed by one-way ANOVA and Tukey’s post-test (p<0.05). Results Mucosal repair, viable osteocytes, and NF-kB immunostaining were observed in the NC, ONE+PS, ONE+PBM, and ONE+aPDT groups. The ONE group showed no mucosal repair, showing empty lacunae and multifocal immunostaining for NF-kB. The ONE+PBM and ONE+aPDT groups had greater deposition of extracellular matrix and less necrotic bone tissue (p<0.05). Conclusion PBM and aPDT treatments for BRONJ were effective for bone and epithelial repair, in addition to reducing inflammation mediated by the decrease of NF-kB protein in the irradiated regions. (aPDT bisphosphonaterelated bisphosphonate related (BRONJ NFkB NF kB model N=30 N30 N 30 (N=30 n=6/group n6group ngroup n 6 (n=6/group) (NC) (ONE) PS (PS) (PBM) weeks 25 µgkg µg kg injections 09 0 9 0.9 saline molar wavelength 660 ~66 nm 5 mW J 6667 66 67 66.6 Jcm2 Jcm cm2 cm J/cm s 03 3 0.3 hematoxylineosin hematoxylin eosin Massons Masson staining antiNFkB anti (anti-NF-kB methods oneway one way Tukeys Tukey posttest post test p<0.05. p005 p p<0.05 . 05 (p<0.05) osteocytes ONEPS ONE+PS ONEPBM ONEaPDT NFkB. kB. regions N=3 N3 (N=3 (n=6/group (NC (ONE (PS (PBM 0. ~6 666 66. p00 p<0.0 (p<0.05 N= (N= ~ p0 p<0. (p<0.0 (N p<0 (p<0. p< (p<0 (p< (p
4.
Surveillance of TB-HIV coinfection in Brazil: a space-time approach
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Santos, Beatriz Almeida
; Ribeiro, Caíque Jordan Nunes
; Santos, Allan Dantas dos
; Sousa, Álvaro Francisco Lopes de
; Siqueira, Thayane Santos
; Andrade, Lucas Almeida
; Santos, Adriano José dos
; Lima, Shirley Verônica Melo Almeida
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ABSTRACT Objective To identify the epidemiological, spatial, and temporal pattern of TB-HIV coinfection in Brazil during the period from 2001 to 2020. Methods: Ecological study using space-time analysis techniques. It included cases of TB-HIV coinfection registered in Brazil from 2001 to 2020. The temporal trend analysis was performed using segmented regression by Joinpoint regression. For spatial analysis, Moran indices were calculated and choropleth maps were produced using TerraView and QGIS software. Results: A stable temporal trend was observed in the incidence rates of TB-HIV coinfection in Brazil during the analyzed period. In addition, high-risk areas for coinfection located in states in the North, Southeast, South, and Midwest regions were identified. Conclusion: There was stability in the incidence of TB-HIV coinfection in Brazil over the last 20 years and heterogeneous geographic distribution of risk areas for the condition.
RESUMO Objective Identificar o padrão epidemiológico, espacial e temporal da coinfecção TB-HIV no Brasil durante o período de 2001 a 2020. Métodos: Estudo ecológico com técnicas de análise espacial e temporal. Incluiu os casos de coinfecção por TB-HIV registrados no Brasil entre 2001 e 2020. A análise de tendência temporal foi realizada por meio da regressão segmentada, através do Joinpoint regression. Para a análise espacial, foram calculados os índices de Moran e construídos mapas coropléticos através dos softwares TerraView e QGIS. Resultados: Observou-se tendência temporal estável das taxas de incidência da coinfecção por TB-HIV no Brasil durante o período analisado. Adicionalmente, foram identificadas áreas de alto risco para coinfecção localizadas em estados das regiões Norte, Sudeste, Sul e Centro-Peste. Conclusão: Houve estabilidade da incidência da coinfecção TB-HIV no Brasil nos últimos 20 anos e distribuição geográfica heterogênea das áreas de risco para o agravo.
5.
Curva de Aprendizagem da Mortalidade Hospitalar da Substituição da Válvula Aórtica Transcateter: Insights do Registro Nacional Brasileiro Transcateter
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Bernardi, Fernando Luiz de Melo
; Abizaid, Alexandre A.
; Brito Jr, Fábio Sândoli de
; Lemos, Pedro A.
; Siqueira, Dimytri Alexandre Alvim de
; Costa, Ricardo Alves
; Leite, Rogério Eduardo Gomes Sarmento
; Mangione, Fernanda Marinho
; Thiago, Luiz Eduardo Koenig São
; Mangione, José A.
; Lima, Valter Correia de
; Oliveira, Adriano Dourado
; Marino, Marcos Antônio
; Cardoso, Carlos José Francisco
; Caramori, Paulo R. A.
; Tumelero, Rogério
; Portela, Antenor Lages Fortes
; Prudente, Mauricio
; Henriques, Leônidas Alvarenga
; Souza, Fabio Solano
; Bezerra, Cristiano Guedes
; Prado Jr, Guy F. A.
; Freitas, Leandro Zacaris Figueiredo
; Nogueira, Ederlon Ferreira
; Meireles, George César Ximenes
; Pope, Renato Bastos
; Guerios, Enio
; Andrade, Pedro Beraldo de
; Santos, Luciano de Moura
; Marchi, Mauricio Felippi de Sá
; Fundão, Nelson Henrique Fantin
; Ribeiro, Henrique Barbosa
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Abstract Background Robust data on the learning curve (LC) of transcatheter aortic valve replacement (TAVR) are lacking in developing countries. Objective To assess TAVR’s LC in Brazil over time. Methods We analyzed data from the Brazilian TAVR registry from 2008 to 2023. Patients from each center were numbered chronologically in case sequence numbers (CSNs). LC was performed using restricted cubic splines adjusted for EuroSCORE-II and the use of new-generation prostheses. Also, in-hospital outcomes were compared between groups defined according to the level of experience based on the CSN: 1st to 40th (initial-experience), 41st to 80th (early-experience), 81st to 120th (intermediate-experience), and over 121st (high-experience). Additional analysis was performed grouping hospitals according to the number of cases treated before 2014 (>40 and ≤40 procedures). The level of significance adopted was <0.05. Results A total of 3,194 patients from 25 centers were included. Mean age and EuroSCORE II were 80.7±8.1 years and 7±7.1, respectively. LC analysis demonstrated a drop in adjusted in-hospital mortality after treating 40 patients. A leveling off of the curve was observed after case #118. In-hospital mortality across the groups was 8.6%, 7.7%, 5.9%, and 3.7% for initial-, early-, intermediate-, and high-experience, respectively (p<0.001). High experience independently predicted lower mortality (OR 0.57, p=0.013 vs. initial experience). Low-volume centers before 2014 showed no significant decrease in the likelihood of death with gained experience, whereas high-volume centers had a continuous improvement after case #10. Conclusion A TAVR LC phenomenon was observed for in-hospital mortality in Brazil. This effect was more pronounced in centers that treated their first 40 cases before 2014 than those that reached this milestone after 2014. (LC (TAVR countries TAVRs s time 200 2023 CSNs. CSNs . (CSNs) EuroSCOREII newgeneration new generation prostheses Also inhospital hospital CSN st th initialexperience, initialexperience , (initial-experience) earlyexperience, earlyexperience early (early-experience) intermediateexperience, intermediateexperience intermediate (intermediate-experience) highexperience. highexperience high (high-experience) 201 >40 (>4 ≤4 procedures. procedures procedures) 005 0 05 <0.05 3194 3 194 3,19 2 included 80781 80 7 8 1 80.7±8. 771 7±7.1 4 118 #118 Inhospital In 86 6 8.6% 77 7.7% 59 5 9 5.9% 37 3.7 initial, initial- early, early- intermediate, intermediate- highexperience, high-experience p<0.001. p0001 p p<0.001 001 (p<0.001) OR 057 57 0.57 p0013 013 p=0.01 vs experience. experience) Lowvolume Low volume highvolume 10 #10 20 202 (CSNs (initial-experience (early-experience (intermediate-experience (high-experience >4 (> ≤ 00 <0.0 319 19 3,1 8078 80.7±8 7±7. 11 #11 8.6 7.7 5.9 3. p000 p<0.00 (p<0.001 0.5 p001 01 p=0.0 #1 > ( <0. 31 3, 807 80.7± 7±7 8. 7. 5. p00 p<0.0 (p<0.00 0. p=0. # <0 80.7 7± p0 p<0. (p<0.0 p=0 < 80. p<0 (p<0. p= p< (p<0 (p< (p
Resumo Fundamento Dados robustos sobre a curva de aprendizagem (LC) da substituição da válvula aórtica transcateter (TAVR) são escassos nos países em desenvolvimento. Objetivo Avaliar a LC da TAVR no Brasil ao longo do tempo. Métodos Analisamos dados do registro brasileiro de TAVR de 2008 a 2023. Pacientes de cada centro foram numerados cronologicamente em número sequencial de caso (NSC). A LC foi realizada usando um spline cúbico restrito ajustado para o EuroSCORE-II e o uso de próteses de nova geração. Ainda, os desfechos hospitalares foram comparados entre grupos definidos de acordo com o nível de experiência, com base no NSC: 1º ao 40º caso (experiência inicial), 41º ao 80º caso (experiência básica), 81º ao 120º caso (experiência intermediária) e 121º caso em diante (experiência alta). Análises adicionais foram conduzidas de acordo com o número de casos tratados antes de 2014 (>40 e ≤40 procedimentos). O nível de significância adotado foi p <0,05. Resultados Foram incluídos 3194 pacientes de 25 centros. A idade média foi 80,7±8,1 anos e o EuroSCORE II médio foi 7±7,1. A análise da LC demonstrou uma queda na mortalidade hospitalar ajustada após o tratamento de 40 pacientes. Um patamar de nivelamento na curva foi observado após o caso 118. A mortalidade hospitalar entre os grupos foi 8,6%, 7,7%, 5,9%, e 3,7% para experiência inicial, básica, intermediária e alta, respectivamente (p<0,001). A experiência alta foi preditora independente de mortalidade mais baixa (OR 0,57, p=0,013 vs. experiência inicial). Centros com baixo volume de casos antes de 2014 não mostraram uma redução significativa na probabilidade de morte com o ganho de experiência, enquanto centros com alto volume de casos antes de 2014 apresentaram uma melhora contínua após o caso de número 10. Conclusão Observou-se um fenômeno de LC para a mortalidade hospitalar do TAVR no Brasil. Esse efeito foi mais pronunciado em centros que trataram seus 40 primeiros casos antes de 2014 que naqueles que o fizeram após 2014. (LC (TAVR desenvolvimento tempo 200 2023 NSC. NSC . (NSC) EuroSCOREII geração Ainda º inicial , inicial) básica básica) alta. alta) 201 >40 (>4 ≤4 procedimentos. procedimentos procedimentos) 005 0 05 <0,05 319 2 80781 80 7 8 1 80,7±8, 771 7±7,1 4 118 86 6 8,6% 77 7,7% 59 5 9 5,9% 37 3 3,7 p<0,001. p0001 p<0,001 001 (p<0,001) OR 057 57 0,57 p0013 013 p=0,01 vs inicial. 10 Observouse Observou se 20 202 (NSC >4 (> ≤ 00 <0,0 31 8078 80,7±8 7±7, 11 8,6 7,7 5,9 3, p000 p<0,00 (p<0,001 0,5 p001 01 p=0,0 > ( <0, 807 80,7± 7±7 8, 7, 5, p00 p<0,0 (p<0,00 0, p=0, <0 80,7 7± p0 p<0, (p<0,0 p=0 < 80, p<0 (p<0, p= p< (p<0 (p< (p
6.
Surveillance of TB-HIV coinfection in Brazil: a space-time approach TBHIV TB HIV Brazil spacetime space time
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Santos, Beatriz Almeida
; Ribeiro, Caíque Jordan Nunes
; Santos, Allan Dantas dos
; Sousa, Álvaro Francisco Lopes de
; Siqueira, Thayane Santos
; Andrade, Lucas Almeida
; Santos, Adriano José dos
; Lima, Shirley Verônica Melo Almeida
.
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ABSTRACT Objective To identify the epidemiological, spatial, and temporal pattern of TB-HIV coinfection in Brazil during the period from 2001 to 2020. Methods: Ecological study using space-time analysis techniques. It included cases of TB-HIV coinfection registered in Brazil from 2001 to 2020. The temporal trend analysis was performed using segmented regression by Joinpoint regression. For spatial analysis, Moran indices were calculated and choropleth maps were produced using TerraView and QGIS software. Results: A stable temporal trend was observed in the incidence rates of TB-HIV coinfection in Brazil during the analyzed period. In addition, high-risk areas for coinfection located in states in the North, Southeast, South, and Midwest regions were identified. Conclusion: There was stability in the incidence of TB-HIV coinfection in Brazil over the last 20 years and heterogeneous geographic distribution of risk areas for the condition. epidemiological TBHIV TB HIV 200 2020 Methods spacetime space time techniques software Results addition highrisk high North Southeast South identified Conclusion 2 condition 202
RESUMO Objective Identificar o padrão epidemiológico, espacial e temporal da coinfecção TB-HIV no Brasil durante o período de 2001 a 2020. Métodos: Estudo ecológico com técnicas de análise espacial e temporal. Incluiu os casos de coinfecção por TB-HIV registrados no Brasil entre 2001 e 2020. A análise de tendência temporal foi realizada por meio da regressão segmentada, através do Joinpoint regression. Para a análise espacial, foram calculados os índices de Moran e construídos mapas coropléticos através dos softwares TerraView e QGIS. Resultados: Observou-se tendência temporal estável das taxas de incidência da coinfecção por TB-HIV no Brasil durante o período analisado. Adicionalmente, foram identificadas áreas de alto risco para coinfecção localizadas em estados das regiões Norte, Sudeste, Sul e Centro-Peste. Conclusão: Houve estabilidade da incidência da coinfecção TB-HIV no Brasil nos últimos 20 anos e distribuição geográfica heterogênea das áreas de risco para o agravo. epidemiológico TBHIV TB HIV 200 2020 Métodos segmentada regression QGIS Resultados Observouse Observou se analisado Adicionalmente Norte Sudeste CentroPeste. CentroPeste Centro Peste. Peste Centro-Peste Conclusão 2 agravo 202
7.
Viability of simultaneously selecting for grain yield and seed physiological quality in maize
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Costa, Júlia Carvalho
; Vilela, Guilherme Leite Dias
; Bruzi, Adriano Teodoro
; Piza, Mateus Ribeiro
; Pádua, José Maria Villela
; Santos, Heloisa Oliveira dos
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RESUMO: Atualmente a demanda não é somente para híbridos de milho mais produtivos, mas também que apresentem alta qualidade fisiológica de sementes. A qualidade de sementes é considerada o somatório dos atributos genéticos, físicos, fisiológicos e sanitários que interferem diretamente no vigor das plantas. Objetivou-se avaliar os parâmetros fisiológicos de sementes dos parentais e híbridos de milho obtidos, por meio de análises fisiológicas e técnicas de análise de imagens, bem como estudar a viabilidade da seleção simultânea para a qualidade fisiológica de sementes e produtividade de grãos. Foram realizados dois experimentos, um à campo e o outro em laboratório. Os parâmetros avaliados em campo foram dias para o florescimento feminino, dias para o florescimento masculino, inserção da 1ª espiga, altura de plantas e produtividade de grãos. Para a qualidade fisiológica foram obtidos os atributos de germinação aos quatro dias, germinação aos sete dias, vigor pelo teste de frio, índice de velocidade de emergência e a razão do comprimento da raiz pelo comprimento da parte aérea através do GroundEye®. Obteve-se a heterose para os caracteres agronômicos e fisiológicos. O desdobramento dos efeitos por meio do contraste entre híbridos e recíprocos permitiu testar o efeito materno. As magnitudes da heterose permitem inferir que quanto maior o número de ciclos seletivos e de recombinação, em média maior será a heterose para os caracteres produtividade de grãos e germinação das sementes. A resposta correlacionada indica que híbridos intervarietais mais produtivos apresentam melhor qualidade fisiológica de sementes. RESUMO genéticos físicos Objetivouse Objetivou se imagens experimentos laboratório feminino masculino ª espiga frio GroundEye GroundEye® Obtevese Obteve materno recombinação
ABSTRACT: Currently, the demand is not only for more productive corn hybrids, but also for those with high physiological seed quality. Seed quality is considered the sum of genetic, physical, physiological and sanitary attributes that directly interfere in plant vigor. The objective of this study was to evaluate the physiological parameters of the seeds of parents and maize inter varietal hybrids obtained in a reciprocal recurrent selection program through physiological and image analysis techniques and either to study the feasibility of simultaneously selecting for seed physiological quality and grain yield. Two experiments were performed, one in the field and the other in the laboratory. The evaluated traits in the field were days of female flowering, days of male flowering, insertion of the 1st ear, plant height and grain yield. For the physiological quality, the attributes of germination at four days, germination at seven days, vigor by the cold test, emergence speed index, and the ratio of the root length to shoot length were obtained using GroundEye®. Heterosis was measured for the agronomic and physiological traits. Through the contrast between the inter varietal crosse hybrids and reciprocals we measured the maternal effect. The magnitudes of heterosis allowed us to infer that as greater as the number of selection and recombination cycles, on average, greater heterosis for the traits grain yield and seed germination. The correlated response indicated that, high yield intervarietal hybrids have better seed physiological quality. ABSTRACT Currently genetic physical performed laboratory flowering st ear test index GroundEye GroundEye® effect cycles average
8.
Berganês, a new sheep breed from the Brazilian semiarid: performance and carcass traits in different sex-classes by univariate and multivariate approaches Berganês semiarid sexclasses sex classes
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Silva Filho, José Renaldo Vilar da
; Moura Neto, João Bandeira de
; Chagas, Ellio Celestino de Oliveira
; Santos, Lays Thayse Alves dos
; Souza, José Ilson Rodrigues de
; Queiroz, Mário Adriano Ávila
; Rodrigues, Rafael Torres de Souza
; Voltolini, Tadeu Vinhas
.
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ABSTRACT. Twenty-four lambs between four and five months of age were divided into sex classes: uncastrated males, castrated males and females, eight for each treatment, with an average body weight of 27.00 ± 3.13 kg. dry matter and water intakes were higher for uncastrated males (p < 0.001). final body weight, body weight at slaughter, average daily gain and cold carcass weight were greater for uncastrated, intermediate for castrated and lower for females (p < 0.05). hot and cold carcass yields were higher for castrated males and females, respectively. (p < 0.05). based on principal component analysis, twenty-five variables were selected out of thirty-two, in some of the seven principal components generated, summarizing 21.87% data dimension. Discriminant analysis identified greater discrimination power for body weight at slaughter, thorax width, thorax depth, fatness, dry matter intake and hot carcass weight. All lambs were classified into their respective sex classes. Therefore, uncastrated males have performed better than castrated ones and both showed higher performance than females. Females and castrated males showed higher carcass yield. Discriminant analysis indicated heterogeneity between sex classes. ABSTRACT Twentyfour Twenty classes treatment 2700 27 00 27.0 313 3 13 3.1 kg p 0.001. 0001 0.001 . 0 001 0.001) slaughter 0.05. 005 0.05 05 0.05) respectively twentyfive twenty thirtytwo, thirtytwo thirty two, two thirty-two generated 2187 21 87 21.87 dimension width depth fatness Therefore yield 270 2 27. 31 1 3. 000 0.00 0.0 218 8 21.8 0. 21.
9.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
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ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
10.
Predictive histopathological factors of nodal metastasis in penile cancer
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Campos, Marcos Adriano Garcia
; Teixeira Júnior, Antonio Augusto Lima
; Calixto, José de Ribamar Rodrigues
; Larges, Joyce Santos
; Pinho, Jaqueline Diniz
; Silva, Gyl Eanes Barros
.
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11.
Dapagliflozin in patients with critical illness: rationale and design of the DEFENDER study illness
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Tavares, Caio de Assis Moura
; Azevedo, Luciano César Pontes de
; Rea-Neto, Álvaro
; Campos, Niklas Söderberg
; Amendola, Cristina Prata
; Bergo, Ricardo Reinaldo
; Kozesinski-Nakatani, Amanda Christina
; David-João, Paula Geraldes
; Westphal, Glauco Adrieno
; Guimarães Júnior, Mário Roberto Rezende
; Lobo, Suzana Margareth Ajeje
; Tavares, Marcos Soares
; Dracoulakis, Marianna Deway Andrade
; Souza, Guilherme Martins de
; Almeida, Guacyra Margarita Batista de
; Gebara, Otavio Celso Eluf
; Tomba, Pablo Oscar
; Albuquerque, Camila Santos N
; Silva, Mariana Castaldi Ramalho
; Pereira, Adriano José
; Damiani, Lucas Petri
; Corrêa, Thiago Domingos
; Serpa-Neto, Ary
; Berwanger, Otavio
; Zampieri, Fernando Godinho
.
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ABSTRACT Background: Critical illness is a major ongoing health care burden worldwide and is associated with high mortality rates. Sodium-glucose cotransporter-2 inhibitors have consistently shown benefits in cardiovascular and renal outcomes. The effects of sodium-glucose cotransporter-2 inhibitors in acute illness have not been properly investigated. Methods: DEFENDER is an investigator-initiated, multicenter, randomized, open-label trial designed to evaluate the efficacy and safety of dapagliflozin in 500 adult participants with acute organ dysfunction who are hospitalized in the intensive care unit. Eligible participants will be randomized 1:1 to receive dapagliflozin 10mg plus standard of care for up to 14 days or standard of care alone. The primary outcome is a hierarchical composite of hospital mortality, initiation of kidney replacement therapy, and intensive care unit length of stay, up to 28 days. Safety will be strictly monitored throughout the study. Conclusion: DEFENDER is the first study designed to investigate the use of a sodium-glucose cotransporter-2 inhibitor in general intensive care unit patients with acute organ dysfunction. It will provide relevant information on the use of drugs of this promising class in critically ill patients. ClinicalTrials.gov registry: NCT05558098 Background rates Sodiumglucose Sodium glucose cotransporter2 cotransporter 2 cotransporter- outcomes sodiumglucose sodium investigated Methods investigatorinitiated, investigatorinitiated investigator initiated, initiated investigator-initiated multicenter openlabel open label 50 11 1 1: mg alone therapy stay Conclusion ClinicalTrialsgov ClinicalTrials gov registry NCT NCT0555809 5 NCT055580 NCT05558 NCT0555 NCT055 NCT05 NCT0
RESUMO Antecedentes: A doença crítica é um importante ônus permanente da assistência médica em todo o mundo e está associada a altas taxas de mortalidade. Os inibidores do cotransportador de sódio-glicose do tipo 2 têm demonstrado consistentemente benefícios nos desfechos cardiovasculares e renais. Os efeitos dos inibidores do cotransportador de sódio-glicose do tipo 2 em doenças agudas ainda não foram devidamente investigados. Métodos: O DEFENDER é um estudo de iniciativa do investigador, multicêntrico, randomizado, aberto, desenhado para avaliar a eficácia e a segurança da dapagliflozina em 500 participantes adultos com disfunção orgânica aguda hospitalizados na unidade de terapia intensiva. Os participantes aptos serão randomizados 1:1 para receber 10mg de dapagliflozina e o tratamento padrão por até 14 dias ou apenas o tratamento padrão. O desfecho primário é um composto hierárquico de mortalidade hospitalar, início de terapia renal substitutiva e tempo de internação na unidade de terapia intensiva, até 28 dias. O monitoramento da segurança será rigoroso durante todo o estudo. Conclusão: O DEFENDER é o primeiro estudo desenvolvido para investigar o uso de um inibidor do cotransportador de sódio-glicose do tipo 2 em pacientes de unidade de terapia intensiva geral com disfunção orgânica aguda. O estudo fornecerá informações relevantes sobre o uso de medicamentos dessa classe promissora em pacientes críticos. Registro ClincalTrials.gov: NCT05558098 Antecedentes sódioglicose sódio glicose renais investigados Métodos investigador multicêntrico randomizado aberto 50 11 1 1: mg hospitalar Conclusão críticos ClincalTrials.gov ClincalTrialsgov ClincalTrials gov NCT NCT0555809 5 NCT055580 NCT05558 NCT0555 NCT055 NCT05 NCT0
12.
Volumetric yield coefficient: the key to regulating virtual credits for Amazon wood coefficient
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ANDRADE, Kauanna Domingues Cabral de
; SANTOS, Ana Paula Ferreira dos
; EMMERT, Fabiano
; SANTOS, Joaquim dos
; LIMA, Adriano José Nogueira
; HIGUCHI, Niro
.
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ABSTRACT In Brazil, all transport and storage of native forest products and by-products must be registered within the DOF (Document of Forestry Origin) system. This computerized platform exists to support control agencies in reducing the sale of forest products obtained illegally. However, this tool still shows only modest results in fulfilling its objectives, since gaps in the system allow illegal wood to be acquired and enter the system as legal wood. The objective of this study was to test whether the volumetric yield coefficient (CRV) of a sawmill on an industrial scale corresponds to the 35% established by Brazilian legislation. The focus was directed at a loophole that allows the accumulation of virtual credits in the DOF system by turning logs into lumber. For this purpose, we estimated the sawmill’s CRV and mean percentage yield of 19 commercial species used by a timber company in the Brazilian Amazon with a sample size of 90 logs. The estimated CRV was 24.6 ± 2.4, showing 9.9% uncertainty. The mean CRV differed highly significantly (p < 0.001) from that proposed by the DOF, with a 10.35% difference. Based on these results, the difference between the observed yield and that proposed by the legislation can generate the accumulation of virtual log credits. With this accumulation, managers encounter difficulties in acquiring new logging permits and, consequently, do not meet the actual demand for logs to the sawmill’s capacity. Brazil byproducts Document Origin illegally However objectives (CRV 35 lumber purpose sawmills s 1 9 246 24 6 24. 2 4 2.4 99 9.9 uncertainty p 0.001 0001 0 001 1035 10 10.35 consequently capacity 3 2. 9. 0.00 000 00 103 10.3 0.0 10. 0.
RESUMO No Brasil, todo transporte e armazenamento de produtos e subprodutos florestais nativos deve ser registrado no sistema DOF (Documento de Origem Florestal). Essa plataforma informatizada existe para apoiar agências de controle na redução da venda de produtos florestais obtidos ilegalmente. No entanto, essa ferramenta ainda apresenta resultados modestos no cumprimento de seus objetivos, uma vez que lacunas no sistema permitem que madeira ilegal adquira caráter legal. O objetivo desse estudo foi testar se o coeficiente de rendimento volumétrico (CRV) de uma serraria em escala empresarial corresponde aos 35% estabelecidos pela legislação brasileira. O foco foi direcionado para uma brecha que permite o acúmulo de créditos virtuais no sistema DOF, por meio da transformação de toras em material serrado. Para tanto, estimamos o CRV da serraria e os rendimentos percentuais médios de 19 espécies comercializadas por uma empresa de base florestal na Amazônia brasileira, com um esforço amostral de 90 toras. O CRV estimado foi de 24,6 ± 2,4, mostrando incerteza de 9,9%. O CRV médio diferiu altamente significativamente (p < 0,001) do proposto pelo DOF, com uma diferença de 10,35%. Com base nesses resultados, a diferença entre o rendimento observado e o proposto pela legislação pode gerar um acúmulo de créditos em toras virtuais. Com esse acúmulo, os gestores enfrentam dificuldades para adquirir novas licenças de exploração e, consequentemente, não atendem à real demanda por toras da capacidade instalada de sua serraria. Brasil Documento Florestal. Florestal . Florestal) ilegalmente entanto objetivos legal (CRV 35 brasileira serrado tanto 1 9 246 24 6 24, 2 4 2,4 99 9,9% p 0,001 0001 0 001 1035 10 10,35% consequentemente 3 2, 9,9 0,00 000 00 103 10,35 9, 0,0 10,3 0, 10,
13.
Clinical characteristics and outcomes of patients with COVID-19 admitted to the intensive care unit during the first and second waves of the pandemic in Brazil: a single-center retrospective cohort study COVID19 COVID 19 COVID-1 Brazil singlecenter single center COVID1 1 COVID-
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Corrêa, Thiago Domingos
; Midega, Thais Dias
; Cordioli, Ricardo Luiz
; Barbas, Carmen Silvia Valente
; Rabello Filho, Roberto
; Silva, Bruno Caldin da
; Silva Júnior, Moacyr
; Nawa, Ricardo Kenji
; Carvalho, Fabrício Rodrigues Torres de
; Matos, Gustavo Faissol Janot de
; Lucinio, Neide Marcela
; Rodrigues, Rodrigo Dias
; Eid, Raquel Afonso Caserta
; Bravim, Bruno de Arruda
; Pereira, Adriano José
; Santos, Bento Fortunato Cardoso dos
; Pinho, João Renato Rebello
; Pardini, Andreia
; Teich, Vanessa Damazio
; Laselva, Claudia Regina
; Cendoroglo Neto, Miguel
; Klajner, Sidney
; Ferraz, Leonardo José Rolim
.
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ABSTRACT Objective To describe and compare the clinical characteristics and outcomes of patients admitted to intensive care units during the first and second waves of the COVID-19 pandemic. Methods In this retrospective single-center cohort study, data were retrieved from the Epimed Monitor System; all adult patients admitted to the intensive care unit between March 4, 2020, and October 1, 2021, were included in the study. We compared the clinical characteristics and outcomes of patients admitted to the intensive care unit of a quaternary private hospital in São Paulo, Brazil, during the first (May 1, 2020, to August 31, 2020) and second (March 1, 2021, to June 30, 2021) waves of the COVID-19 pandemic. Results In total, 1,427 patients with COVID-19 were admitted to the intensive care unit during the first (421 patients) and second (1,006 patients) waves. Compared with the first wave group [median (IQR)], the second wave group was younger [57 (46-70) versus 67 (52-80) years; p<0.001], had a lower SAPS 3 Score [45 (42-52) versus 49 (43-57); p<0.001], lower SOFA Score on intensive care unit admission [3 (1-6) versus 4 (2-6); p=0.018], lower Charlson Comorbidity Index [0 (0-1) versus 1 (0-2); p<0.001], and were less frequently frail (10.4% versus 18.1%; p<0.001). The second wave group used more noninvasive ventilation (81.3% versus 53.4%; p<0.001) and high-flow nasal cannula (63.2% versus 23.0%; p<0.001) during their intensive care unit stay. The intensive care unit (11.3% versus 10.5%; p=0.696) and in-hospital mortality (12.3% versus 12.1%; p=0.998) rates did not differ between both waves. Conclusion In the first and second waves, patients with severe COVID-19 exhibited similar mortality rates and need for invasive organ support, despite the second wave group being younger and less severely ill at the time of intensive care unit admission. COVID19 COVID 19 COVID-1 pandemic singlecenter single center study System 2020 2021 Paulo Brazil May 31 30 total 1427 427 1,42 421 (42 1,006 1006 006 (1,00 median IQR, IQR , (IQR)] 57 [5 4670 46 70 (46-70 6 5280 52 80 (52-80 years p<0.001, p0001 p p<0.001 0 001 p<0.001] 45 [4 4252 42 (42-52 4357 43 (43-57) [ 16 (1-6 26 2 (2-6) p=0.018, p0018 p=0.018 018 p=0.018] 01 (0-1 02 (0-2) 10.4% 104 10 (10.4 18.1% 181 18 p<0.001. . 81.3% 813 81 (81.3 53.4% 534 53 highflow high flow 63.2% 632 63 (63.2 23.0% 230 23 stay 11.3% 113 11 (11.3 10.5% 105 5 p=0.696 p0696 696 inhospital 12.3% 123 12 (12.3 12.1% 121 p=0.998 p0998 998 support COVID1 COVID- 202 142 1,4 (4 1,00 100 00 (1,0 (IQR) 467 7 (46-7 528 8 (52-8 p000 p<0.00 425 (42-5 435 (43-57 (1- (2-6 p001 p=0.01 (0- (0-2 10.4 (10. 18.1 81.3 (81. 53.4 63.2 (63. 23.0 11.3 (11. 10.5 p=0.69 p069 69 12.3 (12. 12.1 p=0.99 p099 99 20 14 ( 1,0 (1, (IQR (46- (52- p00 p<0.0 (42- (43-5 (1 (2- p=0.0 (0 10. (10 18. 81. (81 53. 63. (63 23. 11. (11 p=0.6 p06 12. (12 p=0.9 p09 9 (46 (52 p0 p<0. (43- (2 p=0. (8 (6 (5 p<0 (43 p=0 p< p=
14.
Study of the effectiveness of a ZnO-TiO2 formulation in the degradation of humic substances in mature leachate by solar photocatalysis Brazil ZnOTiO2 ZnOTiO ZnO TiO2 TiO ZnO-TiO
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Nohara, Nicoly Milhardo Lourenço
; Filho, Helcio José Izário
; Siqueira, Adriano Francisco
; Aguiar, Leandro Gonçalves de
; Oliveira, Gabriel Caracciolo Koenigkam de
; Nohara, Evandro Luís
; Alcântara, Marco Aurélio Kondracki de
; Napoleão, Diovana Aparecida dos Santos
.
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Abstract Treatment of landfill leachate is an important environmental issue, especially in developing countries such as Brazil. Advanced oxidation processes (AOPs) have been considered interesting treatment alternatives. In this study, ZnO-TiO2 mixtures were incorporated into a paint polymer matrix and fixed onto supports. Paints were applied by overlapping coat layers on plates, resulting in high film thickness (600 ± 80 µm). Treatment of mature leachate by an AOP was conducted in a plug flow reactor connected to a stirred tank under solar irradiation. The objective was to evaluate the degradation of humic acid (HA) and fulvic acid + humins (FAH). The highest HA and FAH removal efficiencies were 62% ± 4.9% and 16% ± 4.2%, respectively. The kinetic model provided a coefficient of determination (R 2) of 0.974. Rate constants for HA and FAH removal were 2.96 and 1.03 × 10−3 min−1, respectively. Statistical models for HA and FAH degradation had R 2 values of 0.96 and 0.99, respectively. Both approaches indicated that HA degradation is greater at acidic pH and higher TiO2 concentrations. FAH degradation was favored by acidic pH and higher ZnO concentrations. Statistical models showed the same mean difference in conversion between replicate runs of HA and FAH, suggesting a uniform diffusion of fractions through catalysts. issue Brazil AOPs (AOPs alternatives study ZnOTiO2 ZnOTiO TiO ZnO-TiO supports plates 600 (60 8 µm. µm . µm) irradiation (HA FAH. (FAH) 62 49 4 9 4.9 16 42 4.2% respectively 0974 0 974 0.974 296 96 2.9 103 1 03 1.0 10 3 10− min1 min min−1 096 0.9 099 99 0.99 concentrations catalysts 60 (6 (FAH 6 4. 4.2 097 97 0.97 29 2. 1. min− 09 0. (
Resumo O tratamento de chorume de aterro é uma questão ambiental importante, especialmente em países em desenvolvimento como o Brasil. Os processos oxidativos avançados (POA) têm sido considerados interessantes alternativas de tratamento. Neste estudo, misturas de ZnO-TiO2 foram incorporadas a uma matriz polimérica de tinta e fixadas em suportes. As tintas foram aplicadas pela sobreposição de camadas de revestimento em placas, resultando em alta espessura de filme (600 ± 80 µm). O tratamento do lixiviado maduro por um POA foi conduzido em um reator de fluxo contínuo conectado a um tanque de agitação sob irradiação solar. O objetivo foi avaliar a degradação de ácido húmico (HA) e ácido fúlvico + huminas (FAH). As maiores eficiências de remoção de HA e FAH foram 62% ± 4,9% e 16% ± 4,2%, respectivamente. O modelo cinético forneceu um R2 de 0,974. As constantes de velocidade para remoção de HA e FAH foram 2,96 e 1,03 × 10−3 min−1, respectivamente. Os modelos estatísticos para degradação de HA e FAH tiveram valores de R2 de 0,96 e 0,99, respectivamente. Ambas as abordagens indicaram que a degradação do HA é maior em pH ácido e concentrações mais altas de TiO2. A degradação de FAH foi favorecida por pH ácido e maiores concentrações de ZnO. Os modelos estatísticos mostraram a mesma diferença significativa na conversão entre as execuções repetidas, sugerindo uma difusão uniforme das frações através dos catalisadores. importante Brasil (POA estudo ZnOTiO2 ZnOTiO ZnO TiO2 TiO ZnO-TiO suportes placas 600 (60 8 µm. µm . µm) solar (HA FAH. (FAH) 62 49 4 9 4,9 16 42 2 4,2% respectivamente R 0974 0 974 0,974 296 96 2,9 103 1 03 1,0 10 3 10− min1 min min−1 096 0,9 099 99 0,99 repetidas catalisadores 60 (6 (FAH 6 4, 4,2 097 97 0,97 29 2, 1, min− 09 0, (
15.
Use of alternative diluent ACP-Lact® and coconut water powder (ACP) in cryopreservation of goat semen and fixed-time artificial insemination (FTAI) in half-breed goats ACPLact® ACPLact ACP Lact® Lact ACP-Lact (ACP fixedtime fixed time FTAI (FTAI halfbreed half breed
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Cabral, Leonardo Alves Rodrigues
; Pacheco, Wallisson Bruno de Morais
; Santos, Suane Silva Alves dos
; Prado, Adriano da Silva
; Rufino, Luis Alberto Linhares
; Salgueiro, Cristiane Clemente de Mello
; Paula, Ney Rômulo de Oliveira
; Montenegro, Assis Rubens
; Nunes, José Ferreira
.
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Abstract The aim of the present study was to evaluate semen cryopreservation with ACP-Lact® diluent, which consists of coconut water powder (ACP) added to goat milk powder. After thawing, the samples were evaluated for sperm kinetics, membrane evaluation and in vivo insemination. For cryopreservation, a pool was made with the ejaculate of six goats, diluted in four equal aliquots for the respective treatments: T1 (ACP-Lact®); T2 (ACP-Lact® 50%); T3 (ACP + 2.5% egg yolk) and T4 (Tris + 2.5% egg yolk). After dilution of the treatments, the samples were placed in 0.5 ml straws and chilled at a rate of -1.07°C/min. After reaching 4°C and stabilizing for one hour, the straws were placed in nitrogen vapour at -60°C for 15 minutes and then immersed in liquid nitrogen (-196ºC). The straws were thawed in a 37°C water bath and kinetic assessments were performed immediately using a computerized semen analysis program (CSA), viability (EN), membrane functionality (HOST), mitochondrial activity (DAB) and DNA integrity assessment of spermatozoa. For the in vivo experiment, ten goats were inseminated, divided into two groups of five goats each, G1 inseminated with ACP-Lact® and G2 with ACP, by fixed-time artificial insemination (FTAI). Regarding the kinetic parameters, the ACP-Lact® treatment showed higher progressive motility (PM) and sperm velocity than the other treatments (36.77%). In the VSL parameter the ACP-Lact diluent was superior to ACP and Tris. In viability the treatment with ACP-Lact® was superior to the treatment with Tris, 95% and 83% respectively. In FTAI two goats were born out of the 5 goats inseminated with ACP-Lact®. It was concluded that the use of ACP-Lact® for cryopreservation of caprine semen is efficient in maintaining seminal parameters during thawing in vitro and in vivo and proved to be a good alternative extender for the caprine species. ACPLact® ACPLact Lact® Lact kinetics T (ACP-Lact®) (ACP-Lact 50% 50 50%) 25 2 2.5 yolk Tris yolk. . 05 0 0. 1.07°C/min. 107Cmin Cmin 1 07 C min -1.07°C/min 4C 4 hour 60°C 60C 60 196ºC. 196ºC ºC (-196ºC) 37C 37 CSA, CSA , (CSA) EN, EN (EN) HOST, HOST (HOST) DAB (DAB spermatozoa experiment each G fixedtime fixed time FTAI. (FTAI) PM (PM 36.77%. 3677 36.77% 36 77 (36.77%) 95 83 respectively ACPLact®. Lact®. species 2. 1.07°C/min 6 (-196ºC 3 (CSA (EN (HOST (FTAI 367 36.77 7 (36.77% 9 8 36.7 (36.77 36. (36.7 (36. (36 (3 (
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