Abstract This meta-analysis aimed to investigate the effects of propolis on the severity of coronavirus disease symptoms by reducing periodontal disease. PubMed, EMBASE, SciELO, Web of Science, and SCOPUS databases were systematically searched. Studies have been conducted analyzing propolis’s effects on COVID-19 and periodontitis. The study was conducted according to the PRISMA statement and registered in PROSPERO. Risk of Bias (RoB) assessment and meta-analysis of clinical studies were performed (Review Manager 5, Cochrane). The certainty of the evidence was assessed using GradePro (GDT). Studies have shown propolis flavonoids inhibit viral replication in several DNA and RNA viruses, including coronaviruses. Propolis components have an aminopeptidase inhibitor activity that can inhibit the main proteases of SARS viruses and seem to inhibit protein spikes, which are sites of most mutations in SARS-CoV strains. The meta-analysis showed favorable results with the use of propolis on probing depth (95%CI: 0.92; p < 0.001), clinical attachment level (95%CI: 1.48; p < 0.001), gingival index (95%CI: 0.14; p = 0.03), plaque index (95%CI: 0.11; p = 0.23), and blending on probing (95%CI: 0.39; p < 0.001). The antibacterial activity of propolis could be mediated through its direct action on microorganisms or the stimulation of the immune system, activating natural defenses. Thus, propolis inhibits the replication of SARS-CoV-2 as well as its bacterial activity. Treatment with propolis improves general health and facilitates the activation of the immune system against coronavirus.

Abstract Objective To verify the influence of low birth weight and rapid postnatal weight gain and associated factors on blood pressure in adolescence in a population of low socioeconomic status, considering that injuries occur in the perinatal period can be predictors of future metabolic changes and are still poorly explored. Methods A cohort study was carried out with 208 adolescents, 78 born with low weight and 130 born with appropriate weight. The infants were followed up during the first six postnatal months and reassessed at 8 and 18 years of age. The independent variables were birthweight and postnatal weight gain. Rapid postnatal weight gain was defined when above 0.67 z score. The co-variables were sex, maternal height and family income at birth, nutritional status at eight years old, socioeconomic conditions, nutritional status, fat mass index, and physical activity level at 18 years. The outcome variable was blood pressure at 18 years old. The bivariate and multivariable logistic regression analysis were realized and p < 0,05 was considered significant. Results The proportion of adolescents with elevated blood pressure was 37.5%. The multivariable logistic regression analysis showed the variables independently associated with a higher chance of elevated blood pressure in adolescence were rapid postnatal weight gain (OR = 2.74; 95% CI 1.22-6.14; p= 0.014), male sex (OR = 4.15; 95% CI 1.66-10.38; p= 0.002) and being physically active (OR = 2.70; 95% CI 1.08-6.74; p= 0.034). Conclusions The rapid postnatal weight gain was a predictor for elevated blood pressure in adolescence, independently of other factors.

Abstract Background: The use of combined oral contraceptives (COC) is a risk factor for atherosclerotic disease, and physical exercise can minimize this condition. Objective: To verify if high intensity interval training (HIIT) promotes changes in the lipid and inflammatory profile of women using COC. Methods: Sequential crossover study with women aged 20-30 years, classified as irregularly active by the international physical activity questionnaire (IPAQ), when using COC. A physical-clinical assessment was performed with anthropometric measurements, VO2max, and analysis of lipid and inflammatory profile. Participants were divided into 2 groups: the initial intervention group (GII), which began practicing HIIT for 2 months, and the posterior intervention group (GIP), which remained inactive for the same period. The GII and GIP would then alternate their conditions. The collected data was divided into: Initial moment (IM), post-exercise moment (PEM) and post-inactivity (PIM). The statistical analyses were performed using the Statistical Package for the Social Sciences, adopting a significance level of p <0.05 . Results: Twelve women were evaluated. After crossing the GII and GIP data, there was a difference in the C-reactive protein values between the IM of 4 (1.6-6.3 mg/dL) vs. PEM 2 (1.5-5 mg/dL); as well as between the PEM vs. the PIM= 4 (1.5-5.8 mg/dL), with a p -value = 0.04 in the comparisons. There was no change between the “moments” of the lipid profile, although it was possible to notice a reduction in resting HR and an increase in indirect VO2max. Conclusion: The HIIT program was able to reduce the inflammatory profile, but it did not alter the lipid profile of irregularly active women using COC.

RESUMO A alta precisão na estimativa do volume de madeira em florestas tropicais é necessária para apoiar o manejo sustentável. Os scanners a laser terrestres (TLS) podem fornecer estimativas de alta qualidade a partir de variáveis estruturais de árvores. Comparamos estimativas de variáveis do fuste obtidas por TLS e métodos tradicionais em nível de árvore e equações de volume ajustadas usando dados para uma floresta semidecídua sazonal secundária (Mata Atlântica). Também discutimos a viabilidade do TLS em fragmentos florestais hiperdiversos e secundários. Medições tradicionais (Método I) e medidas baseadas em TLS (Método II) foram realizadas em 29 árvores pertencentes a 10 espécies. Foram geradas equações de volume baseadas nos modelos de Schumacher e Hall (SH) e Spurr. O DAP (diâmetro à altura do peito) foi igual para ambos os métodos. A altura total foi superestimada pelo Método II, e a altura comercial apresentou baixa correlação entre os dois métodos. As equações volumétricas ajustadas foram diferentes para ambos os métodos, e aquelas baseadas no modelo de volume SH apresentaram o melhor ajuste. Nossos resultados nos levam a inferir que em florestas secundárias hiperdiversas, as variáveis estruturais das árvores devem ser obtidas via TLS. No entanto, atenção deve ser dada à oclusão das árvores alvo pelo sub-bosque em regeneração e às estimativas de altura, que podem ser influenciadas pelas características da copa das espécies dominantes.

ABSTRACT High accuracy in timber volume estimation in tropical forests is required to support sustainable management. Terrestrial laser scanners (TLS) can provide high-quality estimates from tree structural variables. We compared stem variable estimations obtained by TLS and traditional methods at tree level and adjusted volume equations using data of a secondary seasonal semideciduous forest (Atlantic Forest). We also discuss the feasibility of TLS in hyperdiverse and secondary forest fragments. Traditional measurements (Method I) and TLS-based measurements (Method II) were performed on 29 trees belonging to 10 species. Volume equations based on the Schumacher and Hall (SH) and Spurr models were generated. DBH (diameter at breast height) was equal for both methods. Total height (TH) was overestimated by Method II, and commercial height (CH) showed a low correlation between the two methods. The adjusted volumetric equations were different for both methods, and those based on the SH volume model showed the best fit. Our results lead us to infer that in hyperdiverse secondary forests, tree structural variables should be obtained via TLS. However, attention should be given to the occlusion of target trees by the regenerating understory and to height estimates, which can be biased by the crown characteristics of the dominant species.

ABSTRACT Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells.

RESUMO Objetivo Avaliar o conhecimento da população sobre o glaucoma. Métodos Foi realizado um estudo transversal, descritivo, não controlado, cujo instrumento de coleta de dados foi um questionário contendo perguntas sobre o perfil sociodemográfico e o glaucoma, aplicado em indivíduos, antes e depois da apresentação de vídeo educacional sobre o glaucoma, em Fortaleza (CE), que decidiram participar espontaneamente de uma campanha de prevenção ao glaucoma. Resultados Foram coletados 153 questionários, dentre os quais 130 foram considerados elegíveis, incluindo 65 antes da realização de vídeo educativo e 65 após. Antes e após o vídeo educativo, 80% e 7%, respectivamente, acreditavam que glaucoma não era mais comum em afro-americanos. As questões abordadas eram semelhantes a outras consolidadas na literatura, com o intuito de avaliar o grau de conhecimento dos participantes. Conclusão Foi possível observar um aumento no número de acertos após apresentação de material educativo.

ABSTRACT Objective To evaluate the population awareness of glaucoma. Methods A cross-sectional, descriptive, non-controlled study, using a questionnaire to collect data. The questions addressed sociodemographic profile and glaucoma, and were asked to individuals, before and after the presentation of an educational video on glaucoma. It was conducted in the city of Fortaleza (CE) and the respondents spontaneously decided to participate in a glaucoma prevention campaign. Results A total of 153 questionnaires were collected; in that, 130 were considered eligible, including 65 answered before and 65 after the presentation of the educational video. Before and after the educational video, 80% and 7%, respectively, believed glaucoma was not more common in African Americans. The questions addressed were similar to others already consolidated in the literature, aiming to assess level of knowledge of participants. Conclusion An increase in number of correct answers was observed after presentation of the educational material.

RESUMO Objetivos: Identificar a presença de estresse ocupacional nos profissionais de enfermagem de um hospital universitário do interior de Minas Gerais e analisar a influência das características sociodemográficas e ocupacionais neste agravo. Métodos: Estudo transversal, exploratório e quantitativo, realizado com 124 profissionais de enfermagem de um hospital universitário do interior de Minas Gerais. Para sua efetivação, foi utilizada a versão adaptada e validada para o português da escala Job Stress Scale (JSS). Resultados: A maioria dos profissionais era mulheres (87,9 %), com média de idade de 40,2 anos, 80,6 % eram técnicos de enfermagem e 71,8% da amostra apresentava algum grau de exposição ao estresse ocupacional. Conclusões: O índice de estresse ocupacional foi superior ao observado em estudos anteriores. Os dados obtidos no estudo apontam para a necessidade de implementar medidas institucionais de prevenção ao estresse ocupacional, sobretudo fortalecendo o apoio social no trabalho.

ABSTRACT Objectives: To identify the presence of occupational stress in nursing professionals of a university hospital in the inlands of the state of Minas Gerais and examine influence of sociodemographic and occupational characteristics in this disease. Methods: Cross-sectional, exploratory and quantitative study with 124 professional nurses from a university hospital in the inlands of the state of Minas Gerais. The adapted and validated Portuguese version of the Job Stress Scale (JSS) was used for the performance of the study. Results: Most professionals were women (87.9%) with a mean age of 40.2 years, 80.6% were nursing technicians and 71.8% of the sample had some degree of exposure to occupational stress. Conclusions: The occupational stress index was higher than that observed in previous studies. Data obtained in the study point to the need to implement institutional measures for the prevention of occupational stress, especially by strengthening social support at work.

RESUMEN Objetivos: Identificar la presencia de estrés laboral en los profesionales de enfermería de un hospital universitario en el interior de Minas Gerais y analizar la influencia de las características sociodemográficas y ocupacionales en esta enfermedad. Métodos: Estudio transversal, exploratorio y cuantitativo con 124 profesionales de enfermería de un hospital universitario en el interior de Minas Gerais. Para su efectividad, se utilizó la versión portuguesa adaptada y validada de la escala Job Content Questionnaire (JCQ). Resultados: La mayoría de los profesionales eran mujeres (87,9%), con una edad media de 40,2 años, el 80,6% eran técnicos de enfermería y el 71,8% de la muestra tenía algún grado de exposición al estrés laboral. Conclusiones: El índice de estrés laboral fue mayor que el observado en estudios anteriores. Los datos obtenidos en el estudio apuntan a la necesidad de implementar medidas institucionales para prevenir el estrés laboral, especialmente el fortalecimiento del apoyo social en el trabajo.

ABSTRACT Objectives: To identify the presence of occupational stress in nursing professionals of a university hospital in the inlands of the state of Minas Gerais and examine influence of sociodemographic and occupational characteristics in this disease. Methods: Cross-sectional, exploratory and quantitative study with 124 professional nurses from a university hospital in the inlands of the state of Minas Gerais. The adapted and validated Portuguese version of the Job Stress Scale (JSS) was used for the performance of the study. Results: Most professionals were women (87.9%) with a mean age of 40.2 years, 80.6% were nursing technicians and 71.8% of the sample had some degree of exposure to occupational stress. Conclusions: The occupational stress index was higher than that observed in previous studies. Data obtained in the study point to the need to implement institutional measures for the prevention of occupational stress, especially by strengthening social support at work.

RESUMEN Objetivos: Identificar la presencia de estrés laboral en los profesionales de enfermería de un hospital universitario en el interior de Minas Gerais y analizar la influencia de las características sociodemográficas y ocupacionales en esta enfermedad. Métodos: Estudio transversal, exploratorio y cuantitativo con 124 profesionales de enfermería de un hospital universitario en el interior de Minas Gerais. Para su efectividad, se utilizó la versión portuguesa adaptada y validada de la escala Job Content Questionnaire (JCQ). Resultados: La mayoría de los profesionales eran mujeres (87,9%), con una edad media de 40,2 años, el 80,6% eran técnicos de enfermería y el 71,8% de la muestra tenía algún grado de exposición al estrés laboral. Conclusiones: El índice de estrés laboral fue mayor que el observado en estudios anteriores. Los datos obtenidos en el estudio apuntan a la necesidad de implementar medidas institucionales para prevenir el estrés laboral, especialmente el fortalecimiento del apoyo social en el trabajo.

RESUMO Objetivos: Identificar a presença de estresse ocupacional nos profissionais de enfermagem de um hospital universitário do interior de Minas Gerais e analisar a influência das características sociodemográficas e ocupacionais neste agravo. Métodos: Estudo transversal, exploratório e quantitativo, realizado com 124 profissionais de enfermagem de um hospital universitário do interior de Minas Gerais. Para sua efetivação, foi utilizada a versão adaptada e validada para o português da escala Job Stress Scale (JSS). Resultados: A maioria dos profissionais era mulheres (87,9 %), com média de idade de 40,2 anos, 80,6 % eram técnicos de enfermagem e 71,8% da amostra apresentava algum grau de exposição ao estresse ocupacional. Conclusões: O índice de estresse ocupacional foi superior ao observado em estudos anteriores. Os dados obtidos no estudo apontam para a necessidade de implementar medidas institucionais de prevenção ao estresse ocupacional, sobretudo fortalecendo o apoio social no trabalho.

ABSTRACT Objective to evaluate the psychosocial aspect of the work environment of nursing personnel at a university hospital. Method in this exploratory, quantitative, cross-sectional study of 124 nursing professionals at a university hospital in Minas Gerais state, data were collected between July and September 2018. The Job Stress Scale (JSS) was used. The study was approved by the research ethics committee of the Universidade Federal do Triângulo Mineiro. Results participants were allocated to quadrants of the Demand-Control model, and the following prevalences were identified: 30.6% in high-stress situations; 28.2% in low-stress; 21.8% in active work; and 19.4% in passive work. Conclusion assessment of the psychosocial aspect of the work environment found higher rates of individuals in high-stress jobs among nursing personnel on the wards (41.9%) and in the surgical sector (33.3%).

RESUMEN Objetivo evaluar el aspecto psicosocial del entorno laboral del personal de enfermería de un hospital universitario. Método en este estudio exploratorio, cuantitativo y transversal de 124 profesionales de enfermería de un hospital universitario del estado de Minas Gerais, se recolectaron datos entre julio y septiembre de 2018. Se utilizó la Job Stress Scale (JSS). El estudio fue aprobado por el comité de ética en investigación de la Universidade Federal do Triângulo Mineiro. Resultados los participantes fueron asignados a cuadrantes del modelo Demanda-Control, y se identificaron las siguientes prevalencias: 30,6% en situaciones de alto estrés; 28,2% en bajo estrés; 21,8% en trabajo activo; y el 19,4% en trabajo pasivo. Conclusión la evaluación del aspecto psicosocial del ambiente de trabajo encontró tasas más altas de individuos en trabajos de alto estrés entre el personal de enfermería en las salas (41,9%) y en el sector quirúrgico (33,3%).

RESUMO Objetivo avaliar o aspecto psicossocial do ambiente de trabalho de profissionais de enfermagem de um hospital universitário. Método estudo transversal, exploratório e quantitativo realizado com 124 profissionais de enfermagem de um hospital universitário do interior de Minas Gerais, A coleta de dados foi realizada entre os meses de julho e setembro de 2018 e utilizou-se a Job Stress Scale (JSS). O presente estudo foi aprovado pelo CEP/UFTM. Resultados os profissionais foram alocados nos quadrantes do modelo Demanda-Controle e identificou-se a seguinte prevalência: 30,6% na situação de alta exigência; 28,2% na de baixa exigência; 21,8% de trabalho ativo e 19,4% na situação de trabalho passivo. Conclusão a avaliação do aspecto psicossocial do ambiente de trabalho evidenciou maiores taxas de indivíduos em situação de trabalho de alta exigência entre profissionais de enfermagem atuantes nas enfermarias (41,9%) e no setor de bloco cirúrgico (33,3%).