Pesquisa | SciELO

Abstract: Objective: To determine the exposure to aflatoxin B1 (AFB1) in southern Mexico and the presence of the aflatoxin signature mutation in hepatocellular carcinoma (HCC) tissue from patients from a cancer referral center. Materials and methods: We estimated the prevalence and distribution of AFB1 in a representative sample of 100 women and men from Chiapas using the National Health and Nutrition Survey 2018-19. We also examined the presence of the aflatoxin signature mutation in codon 249 (R249S), and other relevant mutations of the TP53 gene in HCC tissue blocks from 24 women and 26 men treated in a national cancer referral center. Results: The prevalence of AFB1 in serum samples was 85.5% (95%CI 72.1-93.1) and the median AFB1 was 0.117 pg/µL (IQR, 0.050-0.350). We detected TP53 R249S in three of the 50 HCCs (6.0%) and observed four other G>T transversions potentially induced by AFB1. Conclusion: Our analysis provides evidence that AFB1 may have a relevant role on HCC etiology in Mexico.

Resumen: Objetivo: Determinar la exposición a aflatoxina_B1 (AFB1) en el sur de México y la presencia de la mutación característica de AFB1 en tejido de carcinoma hepatocelular (CHC) de pacientes de un centro oncológico. Material y métodos: Se estimó la prevalencia y distribución de AFB1 en una muestra representativa de 100 mujeres y hombres de Chiapas a partir de la Encuesta Nacional de Salud y Nutrición 2018-19. También se observó la presencia de la mutación característica de AFB1 en el codón 249 (R249S), y otras mutaciones relevantes del gen TP53 en bloques de tejido de CHC de 24 mujeres y 26 hombres estudiados en un centro de referencia nacional de oncología. Resultados: La prevalencia de AFB1 en las muestras de suero fue de 85.5% (IC95% 72.1-93.1) y la mediana de la concentración 0.117 pg/µL (IQR, 0.050-0.350). Se detectó TP53 R249S en tres de 50 casos de CHC (6.0%) y se observaron cuatro transversiones G>T potencialmente inducidas por AFB1. Conclusión: El presente análisis proporciona evidencia de que la AFB1 puede tener un papel relevante en la etiología del CHC en México.

https://doi.org/10.21149/13189

ABORDAJE EPIDEMIOLÓGICO EN ESTABLECIMIENTO DE ESTANCIA PROLONGADA DE ADULTOS MAYORES CON ANTECEDENTE DE BROTE DE COVID-19.
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Aguirre, María Fernanda

; Silva, Andrea Paula

; Marro, María Jimena

; Miranda, Lucía Amalia López

; Amezqueta, Gabriel Antonio

; Poncet, Verónica Elena

; Smith, Ramiro Martín Dana

; Lavayén, Silvina

; Zotta, Claudio Marcelo

; Martín, María Eugenia de San

; Salaya, Hernán

; Pagano, Irene

; Uez, Osvaldo Cesar

Revista Argentina de Salud Pública

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Abr 2021, Volume 13 Supl. 1 Páginas 5 - 5

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT INTRODUCTION : During the coronavirus disease pandemic (COVID-19), elderly people in long-term care facilities and their health workers constitute a vulnerable subpopulation with a high risk of hospitalization and death. The objective is to describe the epidemiological approach carried out in a long-term care facility for older adults under active surveillance, in the Mar del Plata-Batán urban area, on December 2020. METHODS : The approach strategy combined the indication to isolate suspected cases, perform RT-PCR and detection of IgG antibodies. RESULTS : 4 detectable results were obtained by RT-PCR for SARS-CoV-2 corresponding to health workers; only one had a history of RT-PCR detection during the initial outbreak that occurred 95 days previously; results in residents were undetectable. There were 40 cases with IgG type antibodies (63.5%); 12 (30%) had no history of detection by RT-PCR in any of the outbreaks. DISCUSSION : Findings indicate that having had a first outbreak episode at the facility conferred immunity on people who had no clinical signs of the disease, possibly preventing the second outbreak from spreading among residents.

RESUMEN INTRODUCCIÓN : Durante la pandemia de enfermedad por el nuevo coronavirus (COVID-19) los adultos mayores residentes en instituciones semicerradas y su personal de salud constituyen una subpoblación vulnerable con riesgo elevado de hospitalización y muerte. OBJETIVO : Describir el abordaje epidemiológico efectuado en un establecimiento de estancia prolongada para adultos mayores bajo vigilancia activa, en el aglomerado urbano Mar del Plata-Batán, en diciembre de 2020. MÉTODOS : La estrategia de abordaje combinó la indicación de aislamiento de los casos sospechosos, la realización de reacción en cadena de la polimerasa en tiempo real (RT-PCR) y la detección de anticuerpos del tipo inmunoglobulina G (IgG). RESULTADOS : Se detectaron 4 casos de infección por el nuevo coronavirus (SARS-CoV-2) por RT-PCR en miembros del personal de salud; solo 1 tenía antecedente de detección por RT-PCR durante el brote inicial ocurrido 95 días antes; los resultados en los residentes fueron negativos. Se encontraron 40 casos con anticuerpos de tipo IgG (63,5%); 12 de ellos (30%) no tenían antecedente de detección mediante RT-PCR en ninguno de los brotes. DISCUSIÓN : Los hallazgos indican que el hecho de haber atravesado un primer episodio de brote en el establecimiento confirió inmunidad a personas que no habían tenido manifestaciones clínicas de la enfermedad, lo cual, probablemente, contribuyó a evitar la propagación del segundo brote entre los residentes.

286 downloads

BRAZILIAN CONSENSUS ON INCIDENTAL GALLBLADDER CARCINOMA
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COIMBRA, Felipe Jose F

; TORRES, Orlando Jorge M

; ALIKHANOV, Ruslan

; AGARWAL, Anil

; PESSAUX, Patrick

; FERNANDES, Eduardo de Souza M

; QUIREZE-JUNIOR, Claudemiro

; ARAUJO, Raphael Leonardo C

; GODOY, André Luis

; WAECHTER, Fabio Luis

; RESENDE, Alexandre Prado de

; BOFF, Marcio Fernando

; COELHO, Gustavo Rego

; REZENDE, Marcelo Bruno de

; LINHARES, Marcelo Moura

; BELOTTO, Marcos

; MORAES-JUNIOR, Jose Maria A

; AMARAL, Paulo Cezar G

; PINTO, Rinaldo Danesi

; GENZINI, Tercio

; LIMA, Agnaldo Soares

; RIBEIRO, Heber Salvador C

; RAMOS, Eduardo José

; ANGHINONI, Marciano

; PEREIRA, Lucio Lucas

; ENNE, Marcelo

; SAMPAIO, Adriano

; MONTAGNINI, André Luis

; DINIZ, Alessandro

; JESUS, Victor Hugo Fonseca de

; SIROHI, Bhawna

; SHRIKHANDE, Shailesh V

; PEIXOTO, Renata D`Alpino

; KALIL, Antonio Nocchi

; JARUFE, Nicolas

; SMITH, Martin

; HERMAN, Paulo

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2020, Volume 33 Nº 1 elocation e1496

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Racional: Carcinoma incidental da vesícula biliar é definido como uma neoplasia descoberta por exame histológico após colecistectomia videolaparoscópica. É potencialmente uma doença curável. Entretanto algumas questões relacionadas ao seu manuseio permanecem controversas e uma estratégia definida está associada com melhor prognóstico. Objetivo: Desenvolver o primeiro consenso baseado em evidências para o manuseio de pacientes com carcinoma incidental da vesícula biliar no Brasil. Métodos: Dezesseis questões foram selecionadas e para responder as questões e 36 membros das sociedades brasileiras e internacionais foram incluídos. As recomendações foram baseadas em evidências da literatura atual. Um relatório final foi enviado para os membros do painel para avaliação de concordância. Resultados: Avaliação intraoperatória da peça cirúrgica, uso de bolsas para retirar a peça cirúrgica e exame histopatológico de rotina, foram recomendados. Avaliação pré-operatória completa é necessária e deve ser realizada assim que o estadiamento final esteja disponível. Avaliação da margem do ducto cístico e biópsia de rotina do linfonodo 16b1 são recomendadas. Quimioterapia deve ser considerada e quimioradioterapia indicada se a margem cirúrgica microscópica seja positiva. Os portais devem ser ressecados excepcionalmente. O estadiamento laparoscópico antes da operação é recomendado, mas o tratamento radical por abordagem minimamente invasiva deve ser realizado apenas em centros especializados em cirurgia hepatopancreatobiliar minimamente invasiva. A extensão da ressecção hepática é aceitável até que seja alcançada a ressecção R0. A linfadenectomia padrão é indicada para tumores iguais ou superiores a T2, mas a ressecção da via biliar não é recomendada de rotina. Conclusões: Recomendações seguras foram preparadas para carcinoma incidental da vesícula biliar, destacando os mais frequentes tópicos do trabalho diário do cirurgião do aparelho digestivo e hepatopancreatobiliar.

ABSTRACT Background: Incidental gallbladder cancer is defined as a cancer discovered by histological examination after cholecystectomy. It is a potentially curable disease. However, some questions related to their management remain controversial and a defined strategy is associated with better prognosis. Aim: To develop the first evidence-based consensus for management of patients with incidental gallbladder cancer in Brazil. Methods: Sixteen questions were selected, and 36 Brazilian and International members were included to the answer them. The statements were based on current evident literature. The final report was sent to the members of the panel for agreement assessment. Results: Intraoperative evaluation of the specimen, use of retrieval bags and routine histopathology is recommended. Complete preoperative evaluation is necessary and the reoperation should be performed once final staging is available. Evaluation of the cystic duct margin and routine 16b1 lymph node biopsy is recommended. Chemotherapy should be considered and chemoradiation therapy if microscopically positive surgical margins. Port site should be resected exceptionally. Staging laparoscopy before reoperation is recommended, but minimally invasive radical approach only in specialized minimally invasive hepatopancreatobiliary centers. The extent of liver resection is acceptable if R0 resection is achieved. Standard lymph node dissection is required for T2 tumors and above, but common bile duct resection is not recommended routinely. Conclusions: It was possible to prepare safe recommendations as guidance for incidental gallbladder carcinoma, addressing the most frequent topics of everyday work of digestive and general surgeons.

https://doi.org/10.1590/0102-672020190001e1496 2194 downloads

Surgery as a component of universal healthcare: Where is South Africa?
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Reddy, Ché L

; Makasa, Emmanuel M

; Biccard, Bruce

; Smith, Martin

; Steyn, Elmin

; Fieggen, Graham

; Maswime, Salome

; Meara, John G

; Chu, Kathryn

SAMJ: South African Medical Journal

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Set 2019, Volume 109 Nº 9 Páginas 624 - 625

Resumo: En | Texto: En | PDF: En

https://doi.org/10.7196/samj.2019.v109i9.14233 193 downloads

THE USE OF SIMULATION TO MODEL THE DISPATCH OF INBOUND CONTAINERS IN PORT TERMINALS
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Sarmiento, Martin Guillermo Cornejo

; Epprecht, Eugenio Kahn

; Oliveira, Fernando Luiz Cyrino

; Rodrigues Junior, Annibal Theophilo S.

; Canchumuni, Smith Washington Arauco

Pesquisa Operacional

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Jan 2019, Volume 39 Nº 1 Páginas 155 - 175

Resumo: En | Texto: En | PDF: En

ABSTRACT This paper describes a study of the dispatch planning/scheduling process for inbound containers handled with a reach stacker. Client container pickup is scheduled at least one day in advance for one of six two-hour time windows (six five-container-high stacks per time window) on a given day. A buffer area is available for the containers to be moved in when clients are being served. The aim of this study was to determine the conditions required to ensure that all the containers are dispatched within the scheduled time window and so meet the clients’ requirements. To this end, the performance indicators were identified and compared using simulations as an analytical tool. The results indicate that the shortest-processing-time (SPT) queueing discipline is preferable to the first-come-first-served (FCFS) discipline and that client arrivals can usefully be restricted to periods shorter than two hours in order to meet container-dispatch and service-quality objectives.

https://doi.org/10.1590/0101-7438.2019.039.01.0155 801 downloads

A survey of the ichthyofauna in the Noetsie Estuary, Western Cape Province, South Africa
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Smith, Martin K.S.

; Rodrigues, Demi

; Currie, Bianca

Koedoe

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2018, Volume 60 Nº 1 Páginas 1 - 7

Resumo: En | Texto: En | PDF: En

The fish assemblage in the Noetsie Estuary, a temporarily open and closed estuary on the southern coast of South Africa, was sampled using multiple gears. A total of 12 species from 8 families were recorded. Collectively, estuarine-dependent marine species dominated seine net catches numerically and in terms of biomass for both sampling seasons. Estuarine round herring (Gilchristella aestuaria) was numerically the dominant species in late summer, while juvenile Mugilidae dominated catches in winter. Size class distributions of various fish species indicate that the estuary both serves a nursery function for important euryhaline marine species and supports estuarine resident taxa. Application of the Estuarine Fish Community Index indicates the ecological condition of the estuary to be 'good'. This study contributes to the species list for the estuary while also reporting the presence of an alien invasive freshwater species, Gambusia affinis. Recommendations include the development of a management plan and the formalisation of an estuarine management committee. CONSERVATION IMPLICATIONS: The Noetsie Estuary serves a nursery function for important euryhaline marine species, while supporting healthy populations of estuarine resident taxa. The presence of one alien invasive fish species is documented with potential implications for the conservation of biodiversity in the estuary.

https://doi.org/10.4102/koedoe.v60i1.1513 274 downloads

Heterogeneidad en los fenotipos inflamatorios de los pacientes con EPOC: rol del recuento celular diferencial en esputo
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Camargo, Bethy

; DiTullio, Fernando

; Bosio, Martín

; Smith, Reynaldo

; Borsini, Eduardo

; Canzonieri, Romina

; Muryan, Alexis

; Iotti, Alejandro

; Salvado, Alejandro

; Glenda, Ernst

Revista americana de medicina respiratoria

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Jun 2016, Volume 16 Nº 2 Páginas 128 - 136

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Smoking is the major cause of COPD; however factors such as age, previous history of asthma, exacerbations, and genetic predisposition could infuence the development of the disease. This could be related with the phenotypes of COPD patients, who would have different responses to inhaled corticosteroids (ICs). Recently, it has been suggested that eosinophils are potential biomarkers that contribute to predict good response to ICs. To test the hypothesis that the presence of eosinophils in sputum could be useful to characterize different phenotypes of COPD patients, we assessed the infammatory cell profles in induced sputum samples from not exacerbated COPD patients. 20 patients with moderate to severe COPD, attending a pulmonary rehabilitation gym, were grouped into eosinophilic (8 patients who presented more than 3% eosinophils in the induced sputum sample) or neutrophilic (9 patients who had more than 60% neutrophils). Only 3 patients were excluded due to contamination of the sputum with epithelial cells. Although there were no-signifcant differences in the pulmonary function tests or the 6-minute walk, the patients with eosinophilia showed higher responsiveness to bronchodilator therapy. Besides this group presented an increase of peripheral eosinophils, higher FeNO and better quality of life (measured by questionnaires) compared with the neutrophilic patients. Induced sputum is an economic non-invasive technique and would be a useful tool to know different infammatory phenotypes in COPD patients.

El tabaquismo es la principal causa de la EPOC, sin embargo, factores como la edad de diagnóstico, la historia previa de asma, exacerbaciones, predisposición genética y otros influirían en el desarrollo de la enfermedad. Esto estaría relacionado con los fenotipos de pacientes con EPOC, los cuales tendrían diferentes respuestas a los corticoides inhalados (CI). Recientemente, ha sido propuesto que los eosinófilos serían potenciales biomarcadores predictores de buena respuesta a los CI. Con la hipótesis de que la presencia de eosinófilos en esputo podría constituir una estrategia para diferenciar fenotipos de pacientes con EPOC, evaluamos los perfiles celulares infamatorios en muestras de esputo inducido en pacientes con EPOC no exacerbados. Para esto, se reclutaron 20 pacientes con EPOC moderado a severo que concurren al gimnasio de rehabilitación respiratoria, los cuales fueron agrupados en eosinofílicos (n: 8, cuando presentaron más de 3% de eosinófilos en la muestra de esputo inducido) o no eosinofílicos (n: 9). Se descartaron 3 muestras por contaminación con células epiteliales. Si bien no se observaron diferencias significativas en los test de función pulmonar o de marcha de 6 minutos, los pacientes con eosinoflia presentaron ligeramente mayor reversibilidad luego del broncodilatador. Además, tuvieron mayor eosinofilia periférica, mayores valores de FeNO y mejor calidad de vida (medida por cuestionarios) que los pacientes no eosinofílicos. El esputo inducido es una técnica no invasiva, económica, que representaría una herramienta útil para conocer los diferentes fenotipos inflamatorios en pacientes con EPOC.

796 downloads

Minimising the 'cost' of laparoscopic cholecystectomy
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Thomson, Sandie R

; Smith, Martin D

SAMJ: South African Medical Journal

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Jun 2015, Volume 105 Nº 6 Páginas 451 - 452

Resumo: En | Texto: En | PDF: En

https://doi.org/10.7196/SAMJ.9791 1200 downloads

10.

New possibilities for research on reef fish across the continental shelf of South Africa
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Bernard, Anthony T.F.

; Götz, Albrecht

; Parker, Denham

; Heyns, Elodie R.

; Halse, Sarah J.

; Riddin, Nicholas A.

; Smith, Martin K.S.

; Paterson, Angus W.

; Winker, Henning

; Fullwood, Laura

; Langlois, Timothy J.

; Harvey, Euan S.

South African Journal of Science

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Out 2014, Volume 110 Nº 9-10 Páginas 01 - 05

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/sajs.2014/a0079 1188 downloads

11.

Perspectives of South African general surgeons regarding their postgraduate training
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Smith, Martin D

South African Journal of Surgery

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Ago 2014, Volume 52 Nº 3 Páginas 66 - 66

Resumo: En | Texto: En | PDF: En

https://doi.org/10.7196/sajs.2391 332 downloads

12.

A METHODOLOGICAL MODEL TO ASSIST IN THE OPTIMIZATION AND RISK MANAGEMENT OF MINING INVESTMENT DECISIONS
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BOTÍN, JOSÉ A.

; GUZMÁN, RONALD R.

; SMITH, MARTIN L.

DYNA

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Dez 2011, Volume 78 Nº 170 Páginas 221 - 226

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Identificar, cuantificar y minimizar el riesgo técnico asociado a las decisiones de inversión es un desafío clave para los directivos de la industria minera y los inversores. Sin embargo, en la mayor parte de los estudios de factibilidad bancables, el análisis de riesgo se basa en la modelización estocástica del “Valor actual neto” del proyecto (VAN) que, en la mayoría de los casos, no aporta a los tomadores de decisión una análisis completo de los riesgos derivados de la incertidumbre técnica y de gestión y por ello, resulta de escasa utilidad en el análisis de riesgo y la optimización del proyecto. Este articulo presenta un planteamiento de la gestión de riesgo basado en la cadena de valor, en el que el riesgo del proyecto se evalúa en cada etapa del ciclo de vida del proyecto, desde la exploración al cierre de la mina, y la gestión del riesgo forma parte de un proceso en etapas de valor agregado y optimización.

Identifying, quantifying, and minimizing technical risks associated with investment decisions is a key challenge for mineral industry decision makers and investors. However, risk analysis in most bankable mine feasibility studies are based on the stochastic modelling of project “Net Present Value” (NPV)which, in most cases, fails to provide decision makers with a truly comprehensive analysis of risks associated with technical and management uncertainty and, as a result, are of little use for risk management and project optimization. This paper presents a value-chain risk management approach where project risk is evaluated for each step of the project lifecycle, from exploration to mine closure, and risk management is performed as a part of a stepwise value-added optimization process.

2747 downloads

13.

Naturalistic and supernaturalistic disclosures: The possibility of relational miracles
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Smith, Amy Fisher

Indo-Pacific Journal of Phenomenology

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Out 2010, Volume 10 Nº 2 Páginas 1 - 13

Resumo: En | Texto: En | PDF: En

This paper explores naturalism and supernaturalism as modes of disclosure that reveal and conceal different aspects of relationality. Naturalism is presented as a worldview or set of philosophical assumptions that posits an objective world that is separable from persons and discoverable or describable via scientific methods. Because psychotherapy tacitly endorses many naturalistic assumptions, psychotherapy relationships may be limited to an instrumentalist ethic premised upon use-value and manipulability. Given these naturalistic limitations, relationships may require a supernatural component - a component which reaches beyond the naturalistic and into the miraculous. The alternative grounding for this supernatural disclosure is found in the philosophy of Martin Heidegger and that of Emmanuel Levinas, the former emphasizing the possibilities inherent in contemplative rather than calculative disclosures, and the latter emphasizing ethical obligation and absolute otherness. A therapeutic case is discussed as an exemplar of both kinds of relational disclosure - that is, naturalistic and supernaturalistic - and the therapeutic and relational consequences of each type of disclosure are explored.

https://doi.org/10.2989/ipjp.2010.10.2.8.1089 550 downloads

14.

Estación Biológica Senda Darwin: Investigación ecológica de largo plazo en la interfase ciencia-sociedad
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CARMONA, MARTÍN R

; ARAVENA, J. C

; BUSTAMANTE-SÁNCHEZ, MARCELA A

; CELIS-DIEZ, JUAN L

; CHARRIER, ANDRÉS

; DÍAZ, IVÁN A

; DÍAZ-FORESTIER, JAVIERA

; DÍAZ, MARÍA F

; GAXIOLA, AURORA

; GUTIÉRREZ, ALVARO G

; HERNANDEZ-PELLICER, CLAUDIA

; IPPI, SILVINA

; JAÑA-PRADO, ROCÍO

; JARA-ARANCIO, PAOLA

; JIMENEZ, JAIME

; MANUSCHEVICH, DANIELA

; NECOCHEA, PABLO

; NUÑEZ-AVILA, MARIELA

; PAPIC, CLAUDIA

; PÉREZ, CECILIA

; PÉREZ, FERNANDA

; REID, SHARON

; ROJAS, LEONORA

; SALGADO, BEATRIZ

; SMITH-RAMÍREZ, CECILIA

; TRONCOSO, ANDREA

; VÁSQUEZ, RODRIGO A

; WILLSON, MARY F

; ROZZI, RICARDO

; ARMESTO, JUAN J

Revista chilena de historia natural

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Mar 2010, Volume 83 Nº 1 Páginas 113 - 142

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Senda Darwin Biological Station (SDBS) is a field research center immersed in the rural landscape of northern Chiloé island (42º S), where remnant patches of the original evergreen forests coexist with open pastures, secondary successional shrublands, Sphagnum bogs, Eucalyptus plantations and other anthropogenic cover types, constituting an agricultural frontier similar to other regions in Chile and Latin America. Since 1994, we have conducted long-term research on selected species of plants (e.g., Pilgerodendron uviferum) and animals (e.g., Aphrastura spinicauda, Dromiciops glirioides) that are considered threatened, poorly known or important for their ecological functions in local ecosystems, and on ecosystems of regional and global relevance (e.g., Sphagnum bogs, North Patagonian and Valdivian rain forests). Research has assessed the responses of species and ecosystems to anthropogenic land-use change, climate change, and the impact of management. During this period, more than 100 scientific publications in national and international journals, and 30 theses (graduate and undergraduate) have been produced by scientists and students associated with SDBS. Because of our understanding of the key role that humans play in ecological processes at this agricultural frontier, since the establishment of SDBS we have been committed to creative research on the communication of science to society and ecological education. The integration of SDBS to the nascent Chilean network of long-term socio-ecological research will consolidate and strengthen basic and applied research to project our work into the next decade.

La Estación Biológica Senda Darwin (EBSD) constituye un centro de investigación inmerso en el paisaje rural del norte de la Isla de Chiloé (42º S), donde fragmentos del bosque siempreverde original coexisten con praderas de uso ganadero, turberas de Sphagnum, matorrales sucesionales, plantaciones de Eucalyptus y otras formaciones de origen antropogénico. Desde 1994 hemos realizado estudios de largo plazo centrados en algunas especies de plantas (e.g., Pilgerodendron uviferum D. Don) y animales (e.g., Aphrastura spinicauda Gmelin, Dromiciops gliroides [Thomas]) catalogados como amenazados o escasamente conocidos y en ecosistemas nativos de importancia regional y global (e.g., turberas de Sphagnum, bosque Valdiviano y Nordpatagónico). Las investigaciones han considerado las respuestas de las especies y de los ecosistemas frente al cambio antropogénico del paisaje y cambio climático, así como los efectos de diferentes formas de manejo. Este escenario es semejante al de otras regiones de Chile y Latinoamérica lo que da generalidad a nuestros resultados y modelos. En este período, investigadores asociados a la EBSD han producido más de un centenar de publicaciones en revistas nacionales e internacionales y 30 tesis de pre y postgrado. Entendiendo el papel clave de los seres humanos en los procesos ecológicos de la zona rural, la EBSD ha desarrollado un programa de educación ecológica y vinculación del avance científico con la sociedad local y nacional. La integración de la EBSD a la naciente red de Sitios de Estudios Socio-Ecológicos de Largo Plazo en Chile consolidará y fortalecerá la investigación básica y aplicada que realizamos para proyectarla hacia la siguiente década.

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La locura en la obra de Lacan: articulaciones con las nociones de cuerpo, manía y sexuación
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Muñoz, Pablo D.

; Leibson, Leonardo

; Smith, María Celeste

; Berger, Andrea

; Acciardi, Mariano

; Castañeda, Cristina

; Basile, Marcela

; Vaneskeheian, Alexis

; Lancí, Martín

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- SciELO Analytics

Dez 2009, Volume 16 Páginas 133 - 142

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

We present in this work the state and forward of the project UBACyT 2008-2010 (P601): "Variations of the concept of madness in the work of J. Lacan. Its incidence in the diagnosis differential neurosis-psychosis". With the goal of specify the formalization of the madness concept in Lacan's work, its translation in clinical terms, and analyse the way in which this formalization reorganizes the previous conceptions of madness developed in psychiatry and psychoanalysis, we investigate here the relation of madness with the concepts of body, mania and sexuation.

En este artículo se presentan algunos avances del proyecto de investigación P601 (2008-2010): "Variaciones del concepto de locura en la obra de J. Lacan. Su incidencia en el diagnóstico diferencial neurosis-psicosis". Con el objetivo de avanzar en la precisión de la formalización del concepto de locura en la enseñanza de Lacan, su traducción en términos clínicos, y ponderar el modo en que dicha formalización reordena las concepciones de la locura desplegadas anteriormente en la psiquiatría y el psicoanálisis, indagamos aquí la relación de la locura con los conceptos de cuerpo, manía y sexuación.

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