EFFECT OF LIQUID SWINE WASTEWATER DOSES ON PHYSICAL, CHEMICAL AND ELECTROCHEMICAL ATTRIBUTES IN A CERRADO OXISOL. The addition of organic residues enhances soil and plant organic matter and nutrient content. To gauge the impact of varying liquid swine waste (LSW) levels on soil, we studied changes in a clayey Oxisol’s physical, chemical, and electrochemical traits from the Cerrado. LSW doses (0, 50, 150, 450, 600 m3 ha−1) were applied to the 0-0.20 m layer in a randomized design with three replicates. Post a 30-day incubation at 60% field capacity, the soil underwent mineralogical, physical (clay dispersed in water - CDW), chemical (sodium adsorption ratio - SAR, cation exchange capacity - CEC, base saturation - V%), and electrochemical (pH in H2O and KCl, ApH, point of zero charge - PZC, point of zero salt effect - PZSE, surface electric potential - iµo, and electrical conductivity - EC) analyses. The levels of exchangeable Ca, K, Mg, Na, and available P increased with increasing LSW doses. Increasing LSW doses in the soil led to an increase in EC, but soil salinization was not observed at the highest dose. With the application of LSW doses, there was a decrease in pH, ApH, PZSE, and an increase in CEC, PZC and ψo. Despite the increase in ψo, low clay dispersibility was observed. PHYSICAL OXISOL content (LSW Oxisols Oxisol s Cerrado 0, 0 (0 50 150 450 60 ha−1 ha1 ha 1 00.20 0020 0.20 20 0-0.2 replicates 30day day 30 mineralogical CDW, CDW , CDW) sodium SAR CEC V%, V V% V%) pH HO H O KCl ApH PZSE iµo EC analyses Ca K Mg Na dose ψo ( 5 15 45 6 ha− 00 00.2 002 020 0.2 2 0-0. 3 4 00. 02 0. 0-0 0-

Alfred Schaeffer (1879-1957) was a German chemist who arrived in Minas Gerais in 1911 hired by the state government to organize the state health service in its newly established capital. He directed the Laboratory of Chemical Analysis of the State, and his analytical methods in dairy and mineral waters became a reference in Brazil. He also became professor of Chemistry at the new Faculty of Medicine of Belo Horizonte and founded the Chemistry Institute of the Engineering School in that city, influencing several students who became important names in Brazilian science. In addition, he was responsible for the assembly and technical coordination of pioneering industries in the dairy and wood distillation sector in the city of Santos Dumont. Later he assumed the post of technical director of Merck, also in Minas Gerais. Moving to Rio de Janeiro, he assumed a chair at the Technical School, working in teaching and research, and remained active even after retiring, publishing in important scientific journals. 18791957 1879 1957 (1879-1957 191 capital State Brazil science addition Dumont Merck Janeiro research retiring journals 1879195 187 195 (1879-195 19 187919 18 (1879-19 1 18791 (1879-1 (1879- (1879 (187 (18 (1 (

ABSTRACT: With advancements in coffee cultivation, several traits may be considered in selection of plants, which must exhibit a set of favorable characteristics. The outturn index, defined as the relationship between the mass of mature fruit and processed beans, emerges as a key factor influencing productivity. This study characterized the outturn over two harvests of 57 clones marketed in the public domain and 10 registered cultivars. The analysis considers the effects of genotypes, measurements, and genetic progress achieved through plant selection. According to the maturation cycle of each clone, washed samples of cherry coffee were collected considering a completely randomized factorial design for characterization of the effects of genotypes, years, and the genotype × years (GY) interaction. The drying, peeling, and the outturn index were individually assessed. Despite the significant effects of the GY interaction, genotypes demonstrated minimal alterations in their ranking across measurements. Clones with higher outturn, including LB30, BRS1216, LB12, N7, LB10, LB20, BRS3220, and AS5, exhibited an average outturn of 25.51%, reflecting a gain of 12.17%. Conversely, clones with lower outturn, such as BG180, GJ30, GJ20, AS7, AS10, P42, N1, and P60, had an average of 19.15%, indicating a reduction of 14.02% compared to the general mean. Analyzing the distribution of the outturn values, 19.4%, 62.7%, and 17.9% of genotypes were classified as high, medium, and low outturn, respectively, providing valuable insights for optimal cultivation strategies. ABSTRACT plants characteristics beans productivity 5 1 cultivars measurements clone (GY interaction drying peeling assessed LB30 LB BRS1216 BRS LB12 N7 N LB10 LB20 BRS3220 AS5 AS 2551 25 51 25.51% 1217 12 17 12.17% Conversely BG180 BG GJ30 GJ GJ20 AS7 AS10 P42 P N1 P60 1915 19 15 19.15% 1402 14 02 14.02 mean values 194 4 19.4% 627 62 7 62.7% 179 9 17.9 high medium respectively strategies LB3 BRS121 LB1 LB2 BRS322 255 2 25.51 121 12.17 BG18 GJ3 GJ2 AS1 P4 P6 191 19.15 140 0 14.0 19.4 6 62.7 17. BRS12 BRS32 25.5 12.1 BG1 19.1 14. 19. 62. BRS1 BRS3 25. 12.

RESUMO: Com o avanço da cafeicultura, múltiplas características devem ser consideradas na seleção de plantas, que devem apresentar um conjunto de atributos favoráveis. O rendimento, definido como a relação de massas entre os frutos maduros e os grãos processados, é um importante componente da produtividade. Este estudo tem como objetivo caracterizar o rendimento ao longo de duas colheitas de 57 clones comercializados em domínio público e 10 cultivares registradas. A análise considera efeitos de genótipos, medições e estimativas de ganhos com a seleção. De acordo com o ciclo de maturação de cada clone, amostras de café cereja foram colhidas considerando um delineamento fatorial inteiramente ao acaso para a caracterização dos efeitos de genótipos, anos e interação genótipo × anos (GA). A secagem, o descascamento e o rendimento foram avaliados individualmente. Apesar dos efeitos significativos da interação GA, os genótipos apresentaram pequenas mudanças no ordenamento de uma medição para a outra. Clones com maior rendimento, entre eles, LB30, BRS1216, LB12, N7, LB10, LB20, BRS3220 e AS5 apresentaram rendimento médio de 25,51% associado a estimativas de ganho de 12,17%. Por outro lado, clones de menor rendimento, como BG180, GJ30, GJ20, AS7, AS10, P42, N1 e P60 tiveram uma média de 19,15% associada a uma redução de 14,02%. A partir da distribuição dos valores, 19,4, 62,7 e 17,9% dos genótipos apresentaram rendimento classificados como alto, médio e baixo, subsidiando o melhor cultivo dos genótipos avaliados. RESUMO cafeicultura plantas favoráveis processados produtividade 5 1 registradas clone GA. GA . (GA) secagem individualmente outra eles LB30 LB BRS1216 BRS LB12 N7 N LB10 LB20 BRS322 AS 2551 25 51 25,51 1217 12 17 12,17% lado BG180 BG GJ30 GJ GJ20 AS7 AS10 P42 P P6 1915 19 15 19,15 1402 14 02 14,02% valores 194 4 19,4 627 62 7 62, 179 9 17,9 alto baixo (GA LB3 BRS121 LB1 LB2 BRS32 255 2 25,5 121 12,17 BG18 GJ3 GJ2 AS1 P4 191 19,1 140 0 14,02 19, 6 17, BRS12 BRS3 25, 12,1 BG1 14,0 BRS1 12, 14,

RESUMO Objetivo: Examinar a associação entre o tempo de tela autorreportado e os sintomas de estresse, ansiedade e depressão em adolescentes. Métodos: Foi realizado estudo com delineamento transversal com 982 adolescentes entre 12-15 anos, matriculados na rede pública de ensino da cidade de Jacarezinho (PR). Para mensurar o tempo de tela, os adolescentes responderam à pergunta: “Considerando um dia típico, quanto tempo você passa assistindo TV, jogando videogame, usando computador ou smartphone?”. O questionário DASS-21 (versão curta) foi utilizado para avaliar os sintomas de depressão, ansiedade e estresse. Análises brutas e ajustadas (idade, sexo e nível de escolaridade materna) entre tempo de tela e indicadores de saúde mental foram realizadas por meio do modelo de regressão linear generalizado, com distribuição de Poisson, adotando a significância de p<0,05. Resultados: Maiores sintomas depressivos foram observados em adolescentes com tempo de tela de 4–6 horas/dia (RP 1,35, IC95% 1,13–1,61) e ≥6 horas/dia (RP 1,88, IC95% 1,62–2,19) quando comparados com seus pares com ≤2 horas/dia. O mesmo foi observado para os sintomas de ansiedade com tempo de tela de 4–6 horas/dia (RP 1,23, IC95% 1,04–1,46) e ≥6 horas/dia (RP 1,50, IC95% 1,28–1,77); e estresse, com 4–6 horas/dia (RP 1,25, IC95% 1,08–1,44) e ≥6 horas/dia (RP 1,49, IC95% 1,30–1,71), também comparados com seus pares com ≤2 horas/dia. Conclusões: O tempo de tela foi associado positivamente com os sintomas de depressão, ansiedade e estresse em adolescentes. Atenção especial deve ser dada àqueles que passam mais de quatro horas por dia em frente a uma tela. Objetivo Métodos 98 1215 12 15 12-1 anos PR. PR . (PR) pergunta Considerando típico TV videogame smartphone. smartphone smartphone?” DASS21 DASS 21 DASS-2 versão curta idade, idade (idade materna generalizado Poisson p005 p 0 05 p<0,05 Resultados 46 4 6 4– horasdia RP 135 1 35 1,35 IC95 IC 1,13–1,61 113161 13 61 ≥ 188 88 1,88 1,62–2,19 162219 62 2 19 ≤ 123 23 1,23 1,04–1,46 104146 04 150 50 1,50 1,28–1,77 128177 28 77 1,28–1,77) 125 25 1,25 1,08–1,44 108144 08 44 149 49 1,49 1,30–1,71, 130171 1,30–1,71 , 30 71 1,30–1,71) Conclusões 9 121 12- (PR smartphone? DASS2 DASS- p00 p<0,0 3 1,3 IC9 1,13–1,6 11316 18 8 1,8 1,62–2,1 16221 1,2 1,04–1,4 10414 5 1,5 1,28–1,7 12817 7 1,08–1,4 10814 14 1,4 13017 1,30–1,7 p0 p<0, 1, 1,13–1, 1131 1,62–2, 1622 1,04–1, 1041 1,28–1, 1281 1,08–1, 1081 1301 1,30–1, p<0 1,13–1 113 1,62–2 162 1,04–1 104 1,28–1 128 1,08–1 108 130 1,30–1 p< 1,13– 11 1,62– 16 1,04– 10 1,28– 1,08– 1,30– 1,13 1,62 1,04 1,28 1,08 1,30 1,1 1,6 1,0

ABSTRACT Objective: To examine the associations between self-reported screen time and symptoms of stress, anxiety, and depression in adolescents. Methods: A cross-sectional study was conducted with 982 adolescents aged between 12 and 15 years, enrolled in public schools in Jacarezinho (PR), Brazil. Screen time was assessed by the question “Considering a typical day, how much time do you spend watching TV, playing videogame, using computer or smartphone?” The DASS-21 questionnaire (short form) was used to assess symptoms of depression, anxiety, and stress. Crude and adjusted analyses (age, sex, and maternal level of education) between screen time and mental disorders symptoms were performed using general linear regression models, with Poisson distribution, with significance level at p<0.05. Results: Higher depressive symptoms were observed in adolescents who reported screen time of 4–6 hours/day (PR 1.35, 95%CI 1.13–1.61) and ≥6 hours/day (PR 1.88, 95%CI 1.62–2.19), compared with their pairs with <2 hours/day. The same was observed for anxiety symptoms with screen time of 4–6 hours/day (PR 1.23, 95%CI 1.04–1.46) and ≥6 hours/day (PR 1.50, 95%CI 1.28–1.77); and stress, with 4–6 hours/day (PR 1.25, 95%CI 1.08–1.44) and ≥6 hours/day (PR 1.49, 95%CI 1.30–1.71), also compared with their pairs with <2 hours/day. Conclusions: Screen time was positively associated with depressive, anxiety, and stress symptoms in adolescents. Special attention should be given to those who spend more than four hours a day in front of a screen. Objective selfreported self Methods crosssectional cross sectional 98 1 years PR, PR , (PR) Brazil Considering TV videogame smartphone smartphone? DASS21 DASS 21 DASS-2 short form age, age (age sex education models distribution p005 p 0 05 p<0.05 Results 46 4 6 4– hoursday 135 35 1.35 95CI CI 95 1.13–1.61 113161 13 61 ≥ 188 88 1.88 1.62–2.19, 162219 1.62–2.19 62 2 19 1.62–2.19) < 123 23 1.23 1.04–1.46 104146 04 150 50 1.50 1.28–1.77 128177 28 77 1.28–1.77) 125 25 1.25 1.08–1.44 108144 08 44 149 49 1.49 1.30–1.71, 130171 1.30–1.71 30 71 1.30–1.71) Conclusions 9 DASS2 DASS- p00 p<0.0 3 1.3 1.13–1.6 11316 18 8 1.8 16221 1.62–2.1 1.2 1.04–1.4 10414 5 1.5 1.28–1.7 12817 7 1.08–1.4 10814 14 1.4 13017 1.30–1.7 p0 p<0. 1. 1.13–1. 1131 1622 1.62–2. 1.04–1. 1041 1.28–1. 1281 1.08–1. 1081 1301 1.30–1. p<0 1.13–1 113 162 1.62–2 1.04–1 104 1.28–1 128 1.08–1 108 130 1.30–1 p< 1.13– 11 16 1.62– 1.04– 10 1.28– 1.08– 1.30– 1.13 1.62 1.04 1.28 1.08 1.30 1.1 1.6 1.0

Abstract The technique of bending wood by vaporization presents itself as a viable option for curvilinear structural projects, such as gridshells. Coniferous woods are often used in roof structures because, in addition to the desired relationship between mechanical strength and density, they allow the complete treatment of the cross-section of the piece. However, characteristics such as the predominance of sapwood or heartwood and the presence of defects are variables that affect structural performance. The aim of this study was to evaluate the bending limit of Acrocarpus laxinifloius (Indian cedar) veneers with a bending radius of 21 cm at different thicknesses. The impact of the predominance of sapwood or heartwood and the presence of defects on the bending strength was also investigated. The literature indicates that plastic flexibilization by steam occurs at 100°C, with 2.4 minutes for each millimeter of lamella thickness, which were the parameters considered in this study. The statistical analysis indicated a thickness limit of 8 mm for the lamellae to bend and the greater presence of sapwood or heartwood, as well as wood defects, did not significantly affect the bending force. projects gridshells because density crosssection cross section piece However performance Indian cedar 2 thicknesses investigated 100C C 100 100°C 24 4 2. force 10 1

Resumo Atécnica de vergamento da madeira por vaporização se apresenta como opção viável para projetos de estruturas curvilíneas, como as gridshells. Madeiras coníferas são comumente adotadas em estruturas de cobertura, pois além da desejada relação entre resistência mecânica e densidade, permitem o completo tratamento da seção transversal da peça. Entretanto, características como a predominância de alburno ou de cerne e a presença de defeitos são variáveis que afetam o desempenho estrutural. O objetivo deste estudo foi avaliar o limite de vergamento de lamelas de Acrocarpus flaxinifloius (cedro indiano) com raio de curvatura de 21 cm em diferentes espessuras. Também se investigou o impacto da predominância de alburno ou cerne e da presença de defeitos na força de vergamento. A literatura indica que a flexibilização plástica por vapor ocorre a 100°C, com 2,4 minutos para cada milímetro de espessura da lamela, parâmetros estes considerados neste estudo. A análise estatística indicou o limite de 8 mm de espessura para o vergamento das lamelas e a maior presença de alburno ou de cerne, bem como os defeitos da madeira, não afetou significativamente a força de vergamento. curvilíneas gridshells cobertura densidade peça Entretanto estrutural cedro indiano 2 espessuras 100C C 100 100°C 24 4 2, lamela 10 1

Resumo Introdução: Este estudo investigou variáveis associadas à mortalidade em receptores de transplante renal (RTR) diagnosticados com doença linfoproliferativa pós-transplante (PTLD, do inglês post-transplant lymphoproliferative disease) e viremia simultânea pelo vírus Epstein-Barr (EBV). Métodos: Estudo de coorte retrospectivo incluindo RTR diagnosticados com PTLD entre 2018 e 2020. Desfecho: óbito em até dois anos após diagnóstico. Resultados: Entre 1.625 RTR que realizaram coleta de viremia para EBV (por PCR, 2018–2020) por qualquer motivo, 238 (14,6%) apresentaram carga viral positiva e 41 (17,2%) PTLD simultânea. Esses 41 pacientes tinham em média 40,1 anos ao diagnóstico e 8,6 anos após o transplante; 26,8% foram induzidos com rATG e 92,7% foram mantidos com tacrolimus e azatioprina (TAC/AZA) como regime imunossupressor. Linfonodos (75,6%) foram o local mais comum de PTLD, seguidos pelo trato gastrointestinal (48,8%), com 61,0% no estágio IV de Lugano e 80,5% PTLD monomórfica. A carga viral média do EBV foi 12.198 UI/mL. A sobrevida dos pacientes em um e dois anos após o diagnóstico foi 60,4% e 46,8%, respectivamente. Na análise de regressão de Cox, a idade ao diagnóstico de PTLD (HR para cada ano = 1,039; p < 0,001) e a carga viral do EBV (HR para cada log = 1,695; p = 0,026) foram associadas ao risco de óbito. Conclusão: Este estudo sugere que, em pacientes predominantemente em uso de TAC/AZA, a PTLD com carga viral simultânea positiva para EBV é um evento tardio, e a pior sobrevida está associada à idade mais avançada e à carga viral de EBV no momento do diagnóstico. Introdução (RTR póstransplante pós (PTLD posttransplant post transplant disease EpsteinBarr Epstein Barr EBV. . (EBV) Métodos 201 2020 Desfecho Resultados 1625 1 625 1.62 PCR 2018–2020 20182020 motivo 23 14,6% 146 14 6 (14,6% 4 17,2% 172 17 2 (17,2% 401 40 40, 86 8 8, 268 26 26,8 927 92 7 92,7 TAC/AZA TACAZA TAC AZA (TAC/AZA imunossupressor 75,6% 756 75 (75,6% 48,8%, 488 48,8% , 48 (48,8%) 610 61 0 61,0 805 80 5 80,5 monomórfica 12198 12 198 12.19 UImL UI mL UI/mL 604 60 60,4 468 46 46,8% respectivamente Cox HR 1,039 1039 039 0,001 0001 001 1,695 1695 695 0,026 0026 026 Conclusão tardio (EBV 20 202 162 62 1.6 2018–202 2018202 14,6 (14,6 17,2 (17,2 26, 9 92, 75,6 (75,6 48,8 (48,8% 61, 80, 1219 19 12.1 60, 46,8 1,03 103 03 0,00 000 00 1,69 169 69 0,02 002 02 16 1. 2018–20 201820 14, (14, 17, (17, 75, (75, 48, (48,8 121 12. 46, 1,0 10 0,0 1,6 2018–2 20182 (14 (17 (75 (48, 1, 0, 2018– (1 (7 (48 ( (4

Abstract Introduction: This study investigated variables associated with mortality in kidney transplant recipients (KTRs) diagnosed with post-transplant lymphoproliferative disease (PTLD) and a simultaneous Epstein-Barr virus (EBV) viremia. Methods: This was a retrospective cohort study enrolling KTRs diagnosed with PTLD between 2018 and 2020. Outcome: death within two years after diagnosis. Results: Among 1,625 KTRs who collected EBV viremia (by PCR, 2018–2020) for any reason, 238 (14.6%) had a positive viral load and 41 (17.2%) simultaneous PTLD. These 41 patients were 40.1 years old at diagnosis and 8.6 years after transplantation; 26.8% were induced with rATG and 92.7% were maintained on tacrolimus and azathioprine (TAC/AZA) as immunosuppressive regimen. Lymph nodes (75.6%) was the most common site of PTLD, followed by the gastrointestinal tract (48.8%), with 61.0% at Lugano stage IV and 80.5% monomorphic PTLD. The mean EBV viral load was 12,198 IU/mL. One- and two-year patient survival post-diagnosis was 60.4% and 46.8%, respectively. In the Cox regression analysis, age at PTLD diagnosis (HR for each year = 1.039; p < 0.001) and EBV viral load (HR for each log = 1.695; p = 0.026) were associated with risk of death. Conclusion: This study suggests that in patients predominantly on TAC/AZA, PTLD with simultaneous EBV positive viral load is a late event, and worse survival is associated with older age and EBV viral load at diagnosis. Introduction (KTRs posttransplant post (PTLD EpsteinBarr Epstein Barr (EBV Methods 201 2020 Outcome Results 1625 1 625 1,62 PCR 2018–2020 20182020 reason 23 14.6% 146 14 6 (14.6% 4 17.2% 172 17 2 (17.2% 401 40 40. 86 8 8. transplantation 268 26 26.8 927 92 7 92.7 TAC/AZA TACAZA TAC AZA (TAC/AZA regimen 75.6% 756 75 (75.6% 48.8%, 488 48.8% , 48 (48.8%) 610 61 0 61.0 805 80 5 80.5 12198 12 198 12,19 IUmL IU mL IU/mL One twoyear postdiagnosis 604 60 60.4 468 46 46.8% respectively analysis HR 1.039 1039 039 0.001 0001 001 1.695 1695 695 0.026 0026 026 Conclusion event 20 202 162 62 1,6 2018–202 2018202 14.6 (14.6 17.2 (17.2 26. 9 92. 75.6 (75.6 48.8 (48.8% 61. 80. 1219 19 12,1 60. 46.8 1.03 103 03 0.00 000 00 1.69 169 69 0.02 002 02 16 1, 2018–20 201820 14. (14. 17. (17. 75. (75. 48. (48.8 121 12, 46. 1.0 10 0.0 1.6 2018–2 20182 (14 (17 (75 (48. 1. 0. 2018– (1 (7 (48 ( (4

RESUMO Nos últimos 30 anos, ocorreram transformações significativas nas relações de trabalho, no sindicalismo e na própria comunicação sindical no Brasil. O avanço do neoliberalismo e das plataformas online expandiu a informalidade, fragmentou as organizações da classe trabalhadora e produziu um proletariado da era digital ainda mais precarizado. Sob os efeitos do capitalismo de plataforma, os trabalhadores de aplicativos começaram a experimentar novos arranjos de resistência a partir da convergência midiática e das possibilidades de existir e lutar em ambientes digitais. Este artigo analisa as experiências de comunicação do grupo de moto-entregadores Galera da Pressão (GDP), em atividade na cidade de Natal, no Estado do Rio Grande do Norte, desde 2020. As reflexões buscaram identificar possíveis semelhanças e diferenças com a tradicional comunicação sindical, a partir da observação de uma paralisação liderada pelo coletivo, em maio de 2022, cujas ações foram registradas no Instagram do grupo.

RESUMEN En los últimos 30 años se han producido importantes transformaciones en las relaciones laborales, en el sindicalismo y en la propia comunicación sindical en Brasil. El avance del neoliberalismo y de las plataformas online ha expandido la informalidad, fragmentado las organizaciones de la clase trabajadora y producido un proletariado de la era digital aún más precario. Bajo los efectos del capitalismo de plataformas, los trabajadores de las aplicaciones han comenzado a experimentar nuevos dispositivos de resistencia basados en la convergencia mediática y en las posibilidades de existir y luchar en entornos digitales. Este artículo analiza las experiencias de comunicación del grupo de repartidores en moto Galera da Pressão (GDP), activo en la ciudad de Natal, en el estado de Rio Grande do Norte, desde 2020. Las reflexiones buscaron identificar posibles similitudes y diferencias con la comunicación sindical tradicional, a partir de la observación de una huelga protagonizada por el colectivo en mayo de 2022, cuyas acciones fueron registradas en la cuenta de Instagram del grupo.

ABSTRACT In the last 30 years, significant transformations have occurred in labor relations, unionism, and union communication itself in Brazil. The advance of neoliberalism and online platforms has expanded informality, fragmented working class organizations, and produced an even more precarious digital age proletariat. Under the effects of platform capitalism, app-based workers began to experiment with new resistance arrangements based on media convergence and the possibilities of existing and fighting in digital environments. This article analyzes the communication experiences of the group of delivery motorcyclists Galera da Pressão (GDP), which has been operating in the city of Natal, in the state of Rio Grande do Norte, since 2020. The reflections sought to identify possible similarities and differences with the traditional union communication, based on the observation of a strike led by the collective, in May 2022, whose actions were recorded on the group's Instagram.

Classes de Recomendação Classe I: Condições para as quais há evidências conclusivas e, na sua falta, consenso geral de que o procedimento é seguro e útil/eficaz. Classe II: Condições para as quais há evidências conflitantes e/ou divergência de opinião sobre a segurança e utilidade/eficácia do procedimento. Classe IIa: Peso ou evidência/opinião a favor do procedimento. A maioria aprova. Classe IIb: Segurança e utilidade/eficácia menos estabelecidas, havendo opiniões divergentes. Classe III: Condições para as quais há evidências e/ou consenso de que o procedimento não é útil/eficaz e, em alguns casos, pode ser prejudicial. Níveis de Evidência Nível A: Dados obtidos a partir de múltiplos estudos randomizados de bom porte, concordantes e/ou de metanálise robusta de estudos randomizados. Nível B: Dados obtidos a partir de metanálise menos robusta, a partir de um único estudo randomizado e/ou de estudos observacionais. Nível C: Dados obtidos de opiniões consensuais de especialistas. I falta útileficaz útil eficaz II eou utilidadeeficácia utilidade eficácia IIa evidênciaopinião evidência aprova IIb estabelecidas divergentes III casos prejudicial porte B observacionais C especialistas

Classes of Recommendation Class I: Conditions for which there is conclusive evidence and, failing that, general agreement that a given procedure is safe and useful/effective. Class II: Conditions for which there is conflicting evidence and/or a divergence of opinion about the safety and usefulness/efficacy of a procedure. Class IIa: Weight or evidence/opinion in favor of the procedure. Most approve. Class IIb: Safety and usefulness/efficacy less well established, with divergence of opinions. Class III: Conditions for which there is evidence and/or general agreement that a procedure is not useful/effective and, in some cases, may be harmful. Levels of Evidence Level A: Data derived from multiple large, concordant randomized trials and/or robust meta-analyses of randomized trials. Level B: Data derived from less robust meta-analyses, from a single randomized trial and/or from observational studies. Level C: Data derived from consensus opinion of experts. I usefuleffective useful effective II andor usefulnessefficacy usefulness efficacy IIa evidenceopinion approve IIb established opinions III cases harmful A large metaanalyses meta analyses B metaanalyses, analyses, studies C experts

ABSTRACT: The Amazonian manatee (Trichechusinunguis) is an aquatic mammal threatened with extinction. However, few studies have investigated the pathogens in this species, which may affect both animal and human health. This study aimed to evaluate the frequency, distribution, and patterns of antimicrobial susceptibility of Staphylococcus spp. and Escherichiacoli colonizing the nasal and rectal cavities of Amazonian manatees kept in captivity at the National Institute for Amazonian Research (INPA) in the state of Amazonas, Brazil. Rectal and nasal swabs from 44 manatees of different ages were used in this study. The genus Staphylococcus was isolated from the nasal swabs of 32 (72.7%) animals, with two individuals harboring more than one species of Staphylococcus. S. sciuri was the most commonly isolated species. Resistance to penicillin was observed in 13 (40.6%) isolates, more frequent than the other antimicrobials tested (P = 0.01). E. coli was isolated from the rectal swabs of all animals, with phylogroup B1 being the most frequent among the strains obtained (P = 0.0008). Four isolates (6.8%) were positive for virulence factors, three of which were classified as enterotoxigenicE. coli (ETEC) and one as enteropathogenicE. coli (EPEC). To our knowledge, this is the first study to evaluate Staphylococcus spp. and E. coli in Amazonian manatee samples. This study revealed nasal colonization by Staphylococcus spp., mainly S. sciuri, and diarrheagenicE. coli isolates, including antimicrobial-resistant strains. ABSTRACT Trichechusinunguis (Trichechusinunguis extinction However health frequency distribution spp INPA (INPA Amazonas Brazil 4 3 72.7% 727 72 7 (72.7% animals S 1 40.6% 406 40 6 (40.6% P 0.01. 001 0.01 . 0 01 0.01) E B 0.0008. 00008 0.0008 0008 0.0008) 6.8% 68 8 (6.8% factors enterotoxigenicE ETEC (ETEC enteropathogenicE EPEC. EPEC (EPEC) knowledge samples diarrheagenicE antimicrobialresistant resistant 72.7 (72.7 40.6 (40.6 00 0.0 0000 0.000 000 6.8 (6.8 (EPEC 72. (72. 40. (40. 0. 0.00 6. (6. (72 (40 (6 (7 (4 (

RESUMO: O peixe-boi amazônico (Trichechus inunguis) é um mamífero aquático ameaçado de extinção. Apesar disso, poucos estudos investigaram patógenos nessa espécie que podem impactar a saúde animal e humana. O objetivo deste estudo foi avaliar a frequência, distribuição e padrões de suscetibilidade antimicrobiana de Staphylococcus sp. e Escherichia coli pertencentes à microbiota nasal e retal de peixes-bois da Amazônia mantidos em cativeiro no Instituto Nacional de Pesquisas da Amazônia (INPA) (Amazonas, Brasil). Foram utilizados suabes retais e nasais de 44 peixes-boi de diferentes idades. O gênero Staphylococcus foi isolado do swab nasal de 32 (72,7%) animais, sendo que dois indivíduos apresentaram mais de uma espécie de Staphylococcus. S. sciuri foi a espécie mais comumente isolada. A resistência à penicilina foi observada em 13 (40,6%) isolados, sendo mais frequente do que os outros antimicrobianos testados (P = 0,01). Escherichia coli foi isolada dos suabes retais de todos os animais, sendo o filogrupo B1 o mais frequente entre as cepas obtidas (P = 0,0008). Quatro isolados (6,8%) foram positivos para fatores de virulência, três dos quais foram classificados como E. coli enterotoxigênica (ETEC) e um isolado como E. coli enteropatogênica (EPEC). Este é o primeiro estudo a avaliar Staphylococcus spp. e E. coli de amostras de peixe-boi da Amazônia. O estudo revelou colonização nasal por Staphylococcus sp., principalmente S. sciuri, e por isolados diarreiogênicos de E. coli, incluindo cepas resistentes a antimicrobianos. RESUMO peixeboi peixe boi Trichechus inunguis extinção disso humana frequência sp peixesbois peixes bois INPA (INPA Amazonas, Amazonas (Amazonas Brasil. Brasil . Brasil) 4 peixesboi idades 3 72,7% 727 72 7 (72,7% animais S 1 40,6% 406 40 6 (40,6% P 0,01. 001 0,01 0 01 0,01) B 0,0008. 00008 0,0008 0008 0,0008) 6,8% 68 8 (6,8% virulência E ETEC (ETEC EPEC. EPEC (EPEC) spp 72,7 (72,7 40,6 (40,6 00 0,0 0000 0,000 000 6,8 (6,8 (EPEC 72, (72, 40, (40, 0, 0,00 6, (6, (72 (40 (6 (7 (4 (

Abstract Introduction: Renal osteodystrophy (ROD) refers to a group of bone morphological patterns that derive from distinct pathophysiological mechanisms. Whether the ROD subtypes influence long-term outcomes is unknown. Our objective was to explore the relationship between ROD and clinical outcomes. Methods: This study is a subanalysis of the Brazilian Registry of Bone Biopsies (REBRABO). Samples from individual patients were classified as having osteitis fibrosa (OF), mixed uremic osteodystrophy (MUO), adynamic bone disease (ABD), osteomalacia (OM), normal/minor alterations, and according to turnover/mineralization/volume (TMV) system. Patients were followed for 3.4 yrs. Clinical outcomes were: bone fractures, hospitalization, major adverse cardiovascular events (MACE), and death. Results: We enrolled 275 participants, of which 248 (90%) were on dialysis. At follow-up, 28 bone fractures, 97 hospitalizations, 44 MACE, and 70 deaths were recorded. ROD subtypes were not related to outcomes. Conclusion: The incidence of clinical outcomes did not differ between the types of ROD. Introduction (ROD mechanisms longterm long term unknown Methods REBRABO. REBRABO . (REBRABO) OF, OF , (OF) MUO, MUO (MUO) ABD, ABD (ABD) OM, OM (OM) normalminor normal minor alterations turnovermineralizationvolume turnover mineralization volume TMV (TMV system 34 3 4 3. yrs fractures hospitalization MACE (MACE) death Results 27 participants 24 90% 90 (90% dialysis followup, followup follow up, up follow-up 2 9 hospitalizations 7 recorded Conclusion (REBRABO (OF (MUO (ABD (OM (MACE (90 (9 (

Resumo Introdução: Osteodistrofia renal (OR) refere-se a um grupo de padrões morfológicos ósseos que decorrem de mecanismos fisiopatológicos distintos. É desconhecido se os subtipos de OR influenciam desfechos em longo prazo. Nosso objetivo foi explorar as relações entre OR e desfechos. Métodos: Este estudo é uma subanálise do Registro Brasileiro de Biópsias Ósseas (REBRABO). As amostras de cada paciente foram classificadas em osteíte fibrosa (OF), osteodistrofia urêmica mista (MUO), doença óssea adinâmica (ABD), osteomalácia (OM), alterações normais/menores, e pelo sistema Remodelação / Mineralização / Volume (RMV). Os pacientes foram acompanhados por 3,4 anos. Os eventos clínicos foram: fraturas ósseas, hospitalizações, eventos cardiovasculares adversos maiores (MACE), e óbito. Resultados: Analisamos 275 indivíduos, 248 (90%) deles estavam em diálise. No acompanhamento, 28 fraturas ósseas, 97 hospitalizações, 44 MACE e 70 óbitos foram registrados. Os subtipos de OR não foram relacionados aos desfechos clínicos. Conclusão: A incidência de desfechos clínicos não diferiu entre os tipos de OR. Introdução (OR referese refere distintos prazo Métodos REBRABO. REBRABO . (REBRABO) OF, OF , (OF) MUO, MUO (MUO) ABD, ABD (ABD) OM, OM (OM) normaismenores normais menores normais/menores RMV. RMV (RMV) 34 3 4 3, anos ósseas hospitalizações MACE, (MACE) óbito Resultados 27 indivíduos 24 90% 90 (90% diálise acompanhamento 2 9 7 registrados Conclusão (REBRABO (OF (MUO (ABD (OM (RMV (MACE (90 (9 (

ABSTRACT Introduction: The superiority of the functional results of robot-assisted radical prostatectomyis still controversial. Despite this, it is known that minimally invasive surgery obtains better results when analyzing blood loss, blood transfusion and length of stay, for example. Several studies have analyzed the impact of the resident physician's involvement on the results of urological surgeries. The simple learning curve for robot-assisted radical prostate surgery is estimated to be around 10 to 12 cases. Learning curve data for robotic surgeons is heterogeneous, making it difficult to analyze. Rare studies compare the results of a radical prostatectomy of an inexperienced surgeon starting his training in open surgery, with the results of the same surgeon, a few years later, starting training in robotic surgery. Objective: to analyze the results of open radical prostatectomy surgeries (ORP) performed by urology residents, comparing them to the results of robot-assisted radical prostatectomy (RARP), performed by these same surgeons, after completing their training in urology. Materials and methods: a retrospective analysis of the cases of only 3 surgeons was performed. 50 patients underwent ORP (group A). The surgeons who operated on the ORP patients were in the 3rd and final year of the urology residency program and beginners in ORP surgery, but with at least 4 years of experience in open surgery. The same surgeons, already trained urologists, began their training in robotic surgery and performed 56 RARP surgeries (group B). For the comparative analysis, data were collected on age, number of lymph nodes removed, surgery time, hospitalization time, drain volume, drain permanence time, indwelling bladdercateter (IBC) permanence time, positive surgical margin, biochemical recurrence, risk classification (ISUP), intra and postoperative complications, urinary incontinence (UI) and erectile dysfunction (ED). The console used was the Da Vinci Si, from Intuitive®. For statistical analysis, the Shapiro-Wilk test verified that the data did not follow normality, the Levene test guaranteed homogeneity, and the Mann-Whitney test performed the comparative analysis of the quantitative data. For the analysis of qualitative data, the Chi-square test was used for nominal variables and the Mann-Whitney U test for ordinal variables. Additionally, the Friedman test analyzed whether there was an improvement in the perception of UI or ED over the months, for each group individually (without comparing them), and the post-hoc Durbin-Conover test, for the results with statistically significant difference. We used a p-value < 0.05, and the Jamovi® program (Version 2.0). Results: there was no statistically significant difference between the groups for age, number of lymph nodes removed, positive surgical margin, biochemical recurrence, risk classification and urinary incontinence. Additionally, we observed that the surgical time was longer in group B. On the other hand, the length of stay, drain volume, drain time, IBC time, complication rate and levels of erectile dysfunction in the third and sixth months were higher in group A, when compared to group B. We also observed that there was no evolutionary improvement in ED over the months in both groups, and that there was a perception of improvement in UI from the 1st to the 3rd month in group A, and from the 1st to the 6th month, and from the 3rd to the 12th month, in group B. Conclusion: the learning curve of RARP is equivalent to the curve of ORP. In general, the results for the robotic group were better, however, the functional results were similar between the groups, with a slight tendency of advantage for the robotic arm. Introduction robotassisted robot assisted controversial this loss stay example physicians physician s 1 heterogeneous later Objective (ORP residents RARP, , (RARP) methods 5 A. A . A) rd urologists B B) age removed volume (IBC margin recurrence ISUP, ISUP (ISUP) complications (UI ED. (ED) Si Intuitive Intuitive® ShapiroWilk Shapiro Wilk normality homogeneity MannWhitney Mann Whitney Chisquare Chi square Additionally without them, them) posthoc post hoc DurbinConover Durbin Conover pvalue p value 005 0 05 0.05 Jamovi Version 2.0. 20 2.0 2 2.0) Results hand st th Conclusion general however arm (RARP (ISUP (ED 00 0.0 2. 0.

Abstract Osteoarthritis (OA) can incapacitate the individual to perform their activities of daily living due to pain. This is an important public health issue that worsens worldwide and in Brazil, since the population goes through an aging process, and has caused increased public spending on the monitoring and maintenance of treatments that can last for years and still not be resolutive. Thus, the search for innovative and effective therapies that can reduce costs becomes necessary. In this context, the present study reports the first application of cell therapy with adipose-derived stem cells in the treatment of cases of OA that are refractory to the conservative treatment, performed in the Brazilian Unified Health System (Sistema Único de Saúde, SUS). The evaluation was performed with the application of the Visual Analog Scale (VAS), the Short Form Health Survey (SF-36) and the Western Ontario and McMaster Universities (WOMAC), specifics for OA evaluation, and also an analysis of the synovial fluid (inflammatory cytokines). The cell therapy improved the scores on the WOMAC, SF-36 and EVA, and reduced the inflammatory process. We observed a decrease of 0.73x in the TNF, of 0,71x in IL-1b, of 0,68x in IL-8, and of 0,70x in IL-10. For IL-6, an increase of 1,48x was observed. Therefore, this cell therapy can be considered promising in aiding the management of this disease, since it improved the patient's pain, decrease inflammatory markers, and enabled the return to activities of daily living, which resulted in an improvement in their quality of life. (OA pain Brazil process resolutive Thus necessary context adiposederived adipose derived Sistema Saúde SUS. SUS . SUS) VAS, VAS , (VAS) SF36 SF 36 (SF-36 WOMAC (WOMAC) cytokines. cytokines cytokines) SF-3 EVA 073x x 0 73x TNF 071x 71x IL1b, IL1b ILb IL 1b, 1b b IL-1b 068x 68x IL8, IL8 8, 8 IL-8 070x 70x IL10. IL10 10. 10 IL-10 IL6, IL6 6, 6 IL-6 148x 1 48x Therefore disease patients patient s markers life (VAS SF3 3 (SF-3 (WOMAC SF- IL- IL1 IL-1 (SF- (SF

Resumo A osteoartrite (OA) pode deixar o indivíduo incapacitado para realizar suas atividades da vida diária devido ao quadro álgico. Essa é uma importante questão de saúde pública que se agrava no mundo inteiro e no Brasil, uma vez que a população passa pelo processo de envelhecimento, e isso causa um aumento nos gastos públicos com o acompanhamento e manutenção dos tratamentos que podem perdurar por anos e mesmo assim não serem resolutivos. Assim, torna-se necessária a busca por terapias inovadoras e eficazes que possam reduzir esses custos. Nesse contexto, o presente estudo relata a primeira aplicação de terapia celular com células-tronco mesenquimais do tecido adiposo no tratamento de OA refratária ao tratamento conservador realizada no Sistema Único de Saúde (SUS). Na avaliação, foram usados os instrumentos Escala Visual Analógica (EVA), os questionários de qualidade de vida Short Form Health Survey (SF-36) e Western Ontario and McMaster Universities (WOMAC), específicos para avaliação da OA, e fez-se uma análise do líquido sinovial (citocinas inflamatórias). A terapia celular melhorou as pontuações no WOMAC, SF-36, e EVA, e reduziu o processo inflamatório. Observou-se redução de 0,73 × do TNF, de 0,71 × da IL-1b, de 0,68 × da IL-8, e de 0,70 × da IL-10. Já para a IL-6, observou-se aumento de 1,48 ×. Portanto, considera-se este tipo de terapia celular promissora no auxílio do manejo desta doença, pois melhorou o quadro álgico do paciente, reduziu os marcadores inflamatórios, e possibilitou o retorno às atividades da vida diária, o que resultou em uma melhora de sua qualidade de vida. (OA Brasil envelhecimento resolutivos Assim tornase torna custos contexto célulastronco células tronco SUS. SUS . (SUS) EVA , (EVA) SF36 SF 36 (SF-36 WOMAC (WOMAC) fezse fez citocinas inflamatórias. inflamatórias inflamatórias) SF36, 36, SF-36 inflamatório Observouse Observou 073 0 73 0,7 TNF 071 71 IL1b, IL1b ILb IL 1b, 1b b IL-1b 068 68 0,6 IL8, IL8 8, 8 IL-8 070 70 IL10. IL10 10. 10 IL-10 IL6, IL6 6, 6 IL-6 observouse observou 148 1 48 1,4 Portanto considerase considera doença paciente inflamatórios (SUS (EVA SF3 3 (SF-3 (WOMAC SF-3 07 7 0, 06 IL- IL1 IL-1 14 4 1, (SF- SF- (SF

ABSTRACT The canonical correlation is used to correlate groups of distinct variables. The objective of this study was to use canonical correlation analysis to evaluate the interaction between water quality attributes clogging-causing and the hydraulic performance of non-pressure compensating drippers operating with dilutions of aquaculture effluent in well water. The experiment was in a completely randomized design in a split-split-plot scheme with three replicates, with five dilutions in the plots (Dilution 1: 100% aquaculture effluent; Dilution 2: 75% aquaculture effluent + 25% well water; Dilution 3: 50% aquaculture effluent + 50% well water; Dilution 4: 25% aquaculture effluent + 75% well water; and Dilution 5: 100% well water), three emitters in the sub-plots (ST (1.6 L h-1), SL (1.6 L h-1) and NJ (1.7 L h-1)), and three operating times in the sub-subplots (0, 80 and 160 hours, in which 0 hours operating time means the start of evaluations). The statistical analyses performed were correlation matrix and canonical analysis. The canonical correlation analysis indicated that when the concentrations of attributes increase, the hydraulic performance of the drippers decreases. The interaction of this group of attributes indicates that the clogging of drippers operating with the five dilutions of aquaculture effluent in well water occurs by the combined action of physical, chemical, and biological agents. The ST dripper was the least sensitive to the group of quality attributes of the dilutions, whereas the most sensitive was the SL dripper. variables cloggingcausing causing nonpressure non pressure splitsplitplot split plot replicates 1 100 2 75 25 3 50 4 5 water, , water) subplots sub 1.6 16 6 (1. h1, h1 h h-1 1.7 17 7 h-1)) subsubplots 0, (0 8 evaluations. evaluations . evaluations) increase decreases physical chemical agents 10 1. (1 h- (

RESUMO A correlação canônica é usada para correlacionar grupos de variáveis distintas. O objetivo deste estudo foi utilizar análise de correlação canônica para avaliar a interação entre atributos de qualidade da água causadores de entupimento e o desempenho hidráulico de gotejadores não autocompensantes operando com diluições de efluente de aquicultura em água de poço. O experimento foi conduzido em delineamento inteiramente casualizado, em esquema de parcelas subsubdivididas, com três repetições, com cinco diluições nas parcelas (Diluição 1: 100% de efluente de aquicultura; Diluição 2: 75% de efluente de aquicultura + 25% de água de poço; Diluição 3 : 50% efluente de aquicultura + 50% água de poço; Diluição 4: 25% efluente de aquicultura + 75% água de poço; e Diluição 5: 100% água de poço), três emissores nas subparcelas (ST (1,6 L h-1) , SL (1,6 L h-1) e NJ (1,7 L h-1)), e três tempos de operação nas subsubparcelas (início do experimento, 80 e 160 horas, em que 0 horas de operação significa o início das avaliações). As análises estatísticas realizadas foram matriz de correlação e análise canônica. A análise de correlação canônica indicou que quando as concentrações dos atributos aumentam, o desempenho hidráulico dos gotejadores diminui. A interação desse grupo de atributos indica que o entupimento dos gotejadores que operam com as cinco diluições de efluente de aquicultura em água de poço ocorre pela ação combinada de agentes físicos, químicos e biológicos. O gotejador ST foi o menos sensível ao grupo de atributos de qualidade das diluições, enquanto o mais sensível foi o gotejador SL. distintas casualizado subsubdivididas repetições 1 100 2 75 25 50 4 5 poço, poço) 1,6 16 6 (1, h1 h h-1 1,7 17 7 h1, h-1)) 8 avaliações. avaliações . avaliações) aumentam diminui físicos biológicos 10 1, (1 h- (

ABSTRACT Purpose: Statins are one of the most prescribed classes of drugs worldwide to treat hypercholesterolemia and dyslipidemia. By lowering the level of cholesterol, the use of statin could cause a reduction in testosterone levels. The objective was to evaluate whether the continued use of statins in patients with hypercholesterolemia causes a deficiency in testosterone and other sex hormones. Materials and Methods: Systematic Review with Meta-analysis, performed in Embase, Medline and Cochrane databases, until May 2023; PROSPERO CRD42021270424protocol. Selection performed by two independent authors with subsequent conference in stages. Methodology based on PRISMA statement. There were selected comparative studies, prospective cohorts (CP), randomized clinical trials (RCT) and cross-sectional studies (CSS) with comparison of testosterone levels before and after statin administration and between groups. Bias analysis were evaluated with Cochrane Tool, The Newcastle-Ottawa Scale (NOS), and using the Assess the Quality of Cross-sectional studies (AXIS) tool. Results: There were found on MedLine, Embase and Cochrane, after selected comparative studies, 10CP and 6RCT and 6CSS for the meta-analysis. In the Forrest plot with 6CSS, a correlation between patients with continuous use of statins and a reduction in total testosterone was evidenced with a statistically significant reduction of 55.02ng/dL (95%CI=[39.40,70.64],I²=91%,p<0.00001). In the analysis with 5RCT, a reduction in the mean total testosterone in patients who started continuous statin use was evidenced, with a statistical significance of 13.12ng/dL (95%CI=[1.16,25.08],I²=0%,p=0.03). Furthermore, the analysis of all prospective studies with 15 articles showed a statistically significant reduction in the mean total testosterone of 9.11 ng/dL (95%CI=[0.16,18.06],I²=37%,p=0.04). A reduction in total testosterone has been shown in most studies and in its accumulated analysis after statin use. However, this decrease was not enough to reach levels below normal. Conclusion: Statins use causes a decrease in total testosterone, not enough to cause a drop below the normal range and also determines increase in FSH levels. No differences were found in LH, Estradiol, SHBG and Free Testosterone analysis. Purpose dyslipidemia cholesterol hormones Methods Metaanalysis, Metaanalysis Meta analysis, Meta-analysis databases 2023 CRD42021270424protocol CRDprotocol CRD protocol stages statement CP, CP , (CP) RCT (RCT crosssectional cross sectional CSS (CSS groups Tool NewcastleOttawa Newcastle Ottawa NOS, NOS (NOS) Crosssectional Cross AXIS (AXIS tool Results MedLine metaanalysis. metaanalysis meta meta-analysis 5502ngdL ngdL 55 02ng dL ng 95%CI=39.40,70.64,I²=91%,p<0.00001. 95CI39407064I²91p000001 CIIp 95%CI= 39.40,70.64 ,I²=91%,p<0.00001 . 95 CI 39 40 70 64 I² 91 p 0 00001 I (95%CI=[39.40,70.64],I²=91%,p<0.00001) 5RCT 1312ngdL 13 12ng 95%CI=1.16,25.08,I²=0%,p=0.03. 95CI1162508I²0p003 1.16,25.08 ,I²=0%,p=0.03 1 16 25 08 03 (95%CI=[1.16,25.08],I²=0%,p=0.03) Furthermore 911 9 11 9.1 95%CI=0.16,18.06,I²=37%,p=0.04. 95CI0161806I²37p004 0.16,18.06 ,I²=37%,p=0.04 18 06 37 04 (95%CI=[0.16,18.06],I²=37%,p=0.04) However Conclusion LH Estradiol 202 (CP (NOS 5 95%CI=39.40,70.64,I²=91%,p<0.00001 95CI39407064I²91p00000 95CI 95%CI 39407064 39.40,70.6 I²91p000001 Ip ,I²=91%,p<0.0000 3 4 7 6 0000 (95%CI=[39.40,70.64],I²=91%,p<0.00001 95%CI=1.16,25.08,I²=0%,p=0.03 95CI1162508I²0p00 1162508 1.16,25.0 I²0p003 ,I²=0%,p=0.0 2 (95%CI=[1.16,25.08],I²=0%,p=0.03 9. 95%CI=0.16,18.06,I²=37%,p=0.04 95CI0161806I²37p00 0161806 0.16,18.0 I²37p004 ,I²=37%,p=0.0 (95%CI=[0.16,18.06],I²=37%,p=0.04 20 95%CI=39.40,70.64,I²=91%,p<0.0000 95CI39407064I²91p0000 3940706 39.40,70. I²91p00000 ,I²=91%,p<0.000 000 (95%CI=[39.40,70.64],I²=91%,p<0.0000 95%CI=1.16,25.08,I²=0%,p=0.0 95CI1162508I²0p0 116250 1.16,25. I²0p00 ,I²=0%,p=0. (95%CI=[1.16,25.08],I²=0%,p=0.0 95%CI=0.16,18.06,I²=37%,p=0.0 95CI0161806I²37p0 016180 0.16,18. I²37p00 ,I²=37%,p=0. 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Abstract The University of São Paulo (USP) is acknowledged for its scientific and cultural significance. This article investigates the extent of USP’s influence on the shaping of Brazil’s governing elites. The study is founded on a quantitative analysis of the academic background of individuals occupying top positions in the federal public administration (Presidents of the Republic, Presidents of the Central Bank, Ministers of State, leaders of the Legislative, Judiciary, and the Public Prosecutor Service) from the 1930s to the present day. The data reveals that USP has made a significant contribution to the education of high-ranking federal members across various spheres, with its influence being predominant. The participation of USP alumni varies over time and between different political regimes, being more pronounced during democratic periods. Moreover, other higher education institutions have also played crucial roles in the formation of governing elites. The diversity of institutions attended by government members reflects the complexity and dynamics of the formation of Brazilian elites, influenced by political and social changes over time. (USP significance USPs s Brazils Brazil elites Republic Bank State Legislative Judiciary Service day highranking high ranking spheres predominant regimes periods Moreover

Resumo A Universidade de São Paulo (USP) é reconhecida por sua importância científica e cultural. O artigo investiga o grau de influência da USP na formação das elites dirigentes do Brasil. O estudo se baseia em uma análise quantitativa da formação acadêmica dos ocupantes do alto escalão da administração pública federal (Presidentes da República, Presidentes do Banco Central, Ministros de Estado, líderes do Legislativo, Judiciário e do Ministério Público) desde os anos 1930 até a atualidade. Os dados revelam que a USP contribuiu significativamente para a formação de membros do alto escalão federal em diferentes esferas e sua influência é dominante. A participação de egressos da USP varia ao longo do tempo e entre diferentes regimes políticos, sendo mais acentuada em períodos democráticos. Além disso, outras instituições de ensino superior também tiveram papéis importantes na formação de elites dirigentes. A diversidade de instituições frequentadas pelos membros do governo reflete a complexidade e a dinâmica da formação das elites brasileiras, influenciada por mudanças políticas e sociais ao longo do tempo. (USP cultural Brasil República Central Estado Legislativo Público 193 atualidade dominante políticos democráticos disso brasileiras 19 1