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[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Data de publicação: 2024-04-08

Resumo: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Mortality and years of life lost related to adverse drug events in Brazil
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Oliveira, Rodrigo Alves de

; Amaral, Rita Goreti

; Lopes, Flavio Marques

Revista de Saúde Pública

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2024, Volume 58 elocation 20

Resumo: En | Texto: En | PDF: En

ABSTRACT OBJECTIVE To assess regional and national mortality and years of life lost (YLL) related to adverse drug events in Brazil. METHODS This is an ecological study in which death records from 2009 to 2018 from the Mortality Information System were analyzed. Codes from the International Classification of Diseases 10th revision (ICD-10) that indicated drugs as the cause of death were identified. The number of deaths and the YLL due to adverse drug events were obtained. Crude, age- and gender-specific, and age-adjusted mortality rates and YLL rates per 100,000 inhabitants were formed by year, age group, gender, and Brazilian Federative Unit. Rate ratios were calculated by comparing rates from 2009 to 2018. A joinpoint regression model was applied for temporal analysis. RESULTS For the selected ICD-10 codes, a total of 95,231 deaths and 2,843,413 YLL were recorded. Mortality rates from adverse drug events increased by a mean of 2.5% per year, and YLL rates increased by 3.7%. Increases in rates were observed in almost all age groups for both genders. Variations in rates were found between Federative Units, with the highest age-adjusted mortality and YLL rates occurring in the Distrito Federal. CONCLUSIONS The numbers and rates of deaths and YLL increased during the study period, and variations in rates of deaths and YLL were observed between Brazilian Federative Units. Information on multiple causes of death from death certificates can be useful for quantifying adverse drug events and analyzing them geographically, by age and by gender.

https://doi.org/10.11606/s1518-8787.2024058005458

Concepção e validação de um modelo de regressão do módulo de resiliência de solos aplicado no dimensionamento empírico-mecanístico de pavimentos empíricomecanístico empírico mecanístico
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Lacerda, João Paulo Ferreira de

; Dias, Yhasmim Vitória Vanderlei

; Costa, Flávio Santos Sousa

; Batista, Nayra Maryelle Silva

; Ribeiro, Antonio Junior Alves

Matéria (Rio de Janeiro)

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2024, Volume 29 Nº 3 elocation e20240220

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT The early appearance of pathologies in sidewalks and failure to meet the design horizon not only cause discomfort for users due to poor road conditions and lack of safety during traffic, but also demand a greater amount of raw materials and capital for restoration, recovery or reconstruction of damaged structures. Empirical-mechanistic flexible sidewalk design methods, such as the new Brazilian design method (MeDiNa), take into account the mechanical behavior of the layers and the sidewalk as a whole and more appropriately represent the relationship between the traffic loads and the sidewalk’s response. MeDiNa uses stiffness parameters such as the modulus of resilience (MR) to carry out an elastic-plastic analysis of the structure. This parameter, in turn, suffers some limitations in use, since it is obtained in the laboratory through dynamic triaxial tests that require the use of complex, expensive equipment, specialized labor, in addition to demanding a significant amount of material and being difficult to implement in practical situations, making the test restricted outside universities and academic institutions. In view of this problem, this article proposes a neural regression model for predicting the resilience modulus obtained from basic and usual geotechnical parameters. In addition, to prove the viability of the model generated, simulations were carried out considering different types of roads, as well as linear and non-linear elastic soil constitutive models. This demonstrates that it is a satisfactory model for predicting the modulus of resilience that can be used on roads with moderate to heavy traffic volumes, when it is not possible to carry out the test. restoration structures Empiricalmechanistic Empirical mechanistic methods MeDiNa, , (MeDiNa) s response MR (MR elasticplastic plastic structure parameter turn complex equipment labor situations institutions problem generated nonlinear non models volumes (MeDiNa

RESUMO O aparecimento precoce de problemas na estrutura dos pavimentos e o não cumprimento do horizonte de projeto não só provocam desconforto aos usuários devido às más condições de rolamento e a falta de segurança durante o tráfego, como também demandam uma maior quantidade de matéria-prima e capital para restauração, recuperação ou reconstrução das estruturas danificadas. Os métodos de dimensionamento de pavimentos flexíveis empíricos-mecanísticos, como o novo método brasileiro de dimensionamento (MeDiNa), consideram o comportamento mecânico das camadas e do pavimento como um todo e representam de maneira mais apropriada a relação existente entre as cargas solicitantes do tráfego e a resposta apresentada pelo pavimento. O MeDiNa faz uso dos parâmetros de rigidez, como o módulo de resiliência (MR), para realizar uma análise elástico-plástica da estrutura. Este parâmetro, por sua vez, sofre algumas limitações de uso, visto que é obtido em laboratório por meio de ensaios triaxiais dinâmicos que exigem a utilização de equipamentos complexos, mão de obra especializada, além de demandar uma quantidade significativa de material e apresentar uma difícil implementação em situações práticas, tornando a execução do ensaio restrita fora das universidades e instituições acadêmicas. Tendo em vista esta problemática, este artigo propõe um modelo neural de regressão para previsão do módulo de resiliência obtido através dos parâmetros geotécnicos básicos e usuais. Ademais, para comprovar a viabilidade do modelo gerado, foram realizadas simulações considerando os diversos tipos de vias, bem como os modelos constitutivos elásticos do solo linear e não-linear. Demonstrando, assim, que se trata de um modelo satisfatório para previsão do módulo de resiliência, que poderá ser empregado tanto em rodovias com volumes de tráfego moderado quanto emvolumes elevados, quando não for possível a realização do ensaio. matériaprima matéria prima restauração danificadas empíricosmecanísticos, empíricosmecanísticos empíricos mecanísticos, mecanísticos empíricos-mecanísticos MeDiNa, , (MeDiNa) rigidez MR, MR (MR) elásticoplástica elástico plástica parâmetro vez complexos especializada práticas acadêmicas problemática usuais Ademais gerado vias nãolinear. nãolinear linear. não-linear Demonstrando assim elevados (MeDiNa (MR

https://doi.org/10.1590/1517-7076-rmat-2023-0220

Agronomic characterization of acerola tree genotypes in the Gurgueia Valley region, Piauí, Brazil region Piauí
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Monte Junior, Francisco Almir Campelo

; Evangelista, Thamyres Yara Lima

; Aguiar, Cibele Divino

; Cavalcante, Emanuela Sousa

; Cunha, Jenilton Gomes da

; Pereira, Gustavo Alves

; Souza, Flávio de França

; Silva Júnior, Gabriel Barbosa da

Ciência Rural

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2024, Volume 54 Nº 9 elocation e20230055

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: A seleção de plantas conduzida em pomares comerciais é baseada principalmente nas características da planta. Este trabalho teve como objetivo caracterizar e selecionar genótipos de aceroleira com características promissoras para cultivo na região do Vale do Gurguéia, Piauí. Foram utilizados 25 genótipos, sendo 15 clones (CL 03, CL 08, CL 09, CL 12, CL 13, CL 14, CL 20, CL 23, CL 26, CL 27, CL 30, CL 31, CL 33, CL 36 e CL 38) e 10 cultivares (BRS 235, BRS 236, BRS 237, BRS 238, BRS 366, Sertaneja, Costa Rita, Morena, Tropicana e Junko). O experimento foi instalado no delineamento de blocos casualizados com três blocos e três plantas por unidade experimental no espaçamento de 4 m x 3 m. Um total de 40% dos genótipos avaliados apresentou formato guarda-chuva, 36% formato semiaberto e 24% formato aberto. Os clones 09, 14 e 12 apresentaram o maior potencial de cultivo da região, com produção mensal de 5,01, 4,30 e 3,70 kg planta-¹ por ano e produtividade de 4,16, 3,59 e 3,08 ton ha-¹, respectivamente. O clone 27, as cultivares BRS 236 e BRS 235 e o clone 14 foram os genótipos mais precoces, requerendo 1.503,3, 1.535,6, 1.686,6 e 1.686,6 DD, respectivamente, para completar seu ciclo. Os clones 09 e 14 se destacaram em relação aos demais e são potencialmente promissores para cultivo na região do Vale do Gurgueia. RESUMO planta Gurguéia Piauí 2 1 03 08 13 20 23 26 27 30 31 33 38 237 238 366 Sertaneja Rita Morena Junko. Junko . Junko) 40 guardachuva, guardachuva guarda chuva, chuva guarda-chuva 24 aberto 501 5 01 5,01 430 4,3 370 70 3,7 planta¹ ¹ planta- 416 16 4,16 359 59 3,5 308 3,0 ha¹, ha¹ ha ¹, ha-¹ respectivamente precoces 15033 503 1.503,3 15356 535 6 1.535,6 16866 686 1.686, DD ciclo 0 Gurgueia 50 5,0 43 4, 37 7 3, 41 4,1 35 ha- 1503 1.503, 1535 53 1.535, 1686 68 1.686 5, 150 1.503 153 1.535 168 1.68 1.50 1.53 1.6 1.5 1.

ABSTRACT: Plant selection conducted in commercial orchards is mainly based on plant features. This study characterizes and selects acerola tree genotypes with promising features for cultivation in the Gurguéia Valley region, Piauí. Twenty-five genotypes were used, consisting of 15 clones (CL 03, CL 08, CL 09, CL 12, CL 13, CL 14, CL 20, CL 23, CL 26, CL 27, CL 30, CL 31, CL 33, CL 36, and CL 38) and 10 cultivars (BRS 235, BRS 236, BRS 237, BRS 238, BRS 366, Sertaneja, Costa Rita, Morena, Tropicana, and Junko). The experiment was set up in a randomized block design with three blocks and three plants per experimental unit in 4 m x 3 m spacing. A total of 40% of the genotypes evaluated showed an umbrella shape, 36% showed a semi-open shape, and 24% showed an open shape. Clones 09, 14, and 12 presented the highest cultivation potential in the region, with monthly production of 5.01, 4.30, and 3.70 kg plant-¹ per year and productivity of 4.16, 3.59, and 3. 08-ton ha-¹, respectively. Clone 27, cultivars BRS 236 and BRS 235, and clone 14 were the earliest genotypes, requiring 1,503.3, 1,535.6, 1,686.6, and 1,686.6 DD; respectively, to complete their cycle. Clones 09 and 14 stood out from the others and are potentially promising for cultivation in the Gurgueia Valley region. ABSTRACT region Piauí Twentyfive Twenty five used 1 03 08 13 20 23 26 27 30 31 33 36 38 235 237 238 366 Sertaneja Rita Morena Tropicana Junko. Junko . Junko) spacing 40 shape semiopen semi 24 501 5 01 5.01 430 4.30 370 70 3.7 plant¹ ¹ plant- 416 16 4.16 359 59 3.59 08ton ton ha¹, ha¹ ha ¹, ha-¹ respectively 15033 503 1,503.3 15356 535 6 1,535.6 16866 686 1,686. DD cycle 0 2 50 5.0 43 4.3 37 7 41 4.1 35 3.5 ha- 1503 1,503. 1535 53 1,535. 1686 68 1,686 5. 4. 150 1,503 153 1,535 168 1,68 1,50 1,53 1,6 1,5 1,

https://doi.org/10.1590/0103-8478cr20230055

Mortality and years of life lost related to adverse drug events in Brazil
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Oliveira, Rodrigo Alves de

; Amaral, Rita Goreti

; Lopes, Flavio Marques

Revista de Saúde Pública

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2024, Volume 58 elocation 20

Resumo: En | Texto: En | PDF: En

https://doi.org/10.11606/s1518-8787.2024058005458

OCCURRENCE OF DIETHYL PHTHALATE (DEP) IN FOOD USING DIFFERENT PACKAGING: DETECTION AND TRACEABILITY DEP (DEP PACKAGING
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Almeida, Maria Carolina de

; Sá, Fernando Pereira de

; Ishizawa, Taís Aragão

; Silva, Flávio Alves da

; Pereira, Julião

; Oliveira, Tatianne Ferreira de

Química Nova

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2024, Volume 47 Nº 7 elocation e-20240019

Resumo: En | Texto: En | PDF: En

The objective of this work was the detection and traceability of the occurrence of diethyl phthalate (DEP) migrating from flexible packaging to food. Brazil is one of the largest producers of flexible plastics widely used in food. The evaluation of migrations of contaminants for food, mainly fatty foods, elucidates the possible transmission of diseases through the daily consumption of migrant contaminants from packaging. Throughout an accurate and highly specific methodology, with no use of simulants or organic solvents during sample preparation, the proposal of this study obtained a direct DEP ranking through migration traceability via headspace: HS-GC-MS. Of the 9 samples of flexible packaging and packaged foods analyzed, DEP was identified in 100%, thus confirming its occurrence in foods. Despite the storage conditions: temperature, shelf life, fat content of the products and the manufacturer’s assessment of use. It is urgent to review official standards to promote intense restrictions on the occurrence of DEP in food and encourage the benefits of reflecting daily consumption habits. (DEP methodology preparation headspace HSGCMS. HSGCMS HS GC MS. MS HS-GC-MS analyzed 100 100% conditions temperature life manufacturers manufacturer s habits 10 1

https://doi.org/10.21577/0100-4042.20240019

Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024 202 20 2
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Fernandes, Fabio

; Simões, Marcus V.

; Correia, Edileide de Barros

; Marcondes-Braga, Fabiana Goulart

; Coelho-Filho, Otavio Rizzi

; Mesquita, Cláudio Tinoco

; Mathias Junior, Wilson

; Antunes, Murillo de Oliveira

; Arteaga-Fernández, Edmundo

; Rochitte, Carlos Eduardo

; Ramires, Felix José Alvarez

; Alves, Silvia Marinho Martins

; Montera, Marcelo Westerlund

; Lopes, Renato Delascio

; Oliveira Junior, Mucio Tavares de

; Scolari, Fernando Luis

; Avila, Walkiria Samuel

; Canesin, Manoel Fernandes

; Bocchi, Edimar Alcides

; Bacal, Fernando

; Moura, Lidia Zytynski

; Saad, Eduardo Benchimol

; Scanavacca, Mauricio Ibrahim

; Valdigem, Bruno Pereira

; Cano, Manuel Nicolas

; Abizaid, Alexandre Antonio Cunha

; Ribeiro, Henrique Barbosa

; Lemos Neto, Pedro Alves

; Ribeiro, Gustavo Calado de Aguiar

; Jatene, Fabio Biscegli

; Dias, Ricardo Ribeiro

; Beck-da-Silva, Luis

; Rohde, Luis Eduardo Paim

; Bittencourt, Marcelo Imbroinise

; Pereira, Alexandre da Costa

; Krieger, José Eduardo

; Villacorta Junior, Humberto

; Martins, Wolney de Andrade

; Figueiredo Neto, José Albuquerque de

; Cardoso, Juliano Novaes

; Pastore, Carlos Alberto

; Jatene, Ieda Biscegli

; Tanaka, Ana Cristina Sayuri

; Hotta, Viviane Tiemi

; Romano, Minna Moreira Dias

; Albuquerque, Denilson Campos de

; Mourilhe-Rocha, Ricardo

; Hajjar, Ludhmila Abrahão

; Brito Junior, Fabio Sandoli de

; Caramelli, Bruno

; Calderaro, Daniela

; Farsky, Pedro Silvio

; Colafranceschi, Alexandre Siciliano

; Pinto, Ibraim Masciarelli Francisco

; Vieira, Marcelo Luiz Campos

; Danzmann, Luiz Claudio

; Barberato, Silvio Henrique

; Mady, Charles

; Martinelli Filho, Martino

; Torbey, Ana Flavia Malheiros

; Schwartzmann, Pedro Vellosa

; Macedo, Ariane Vieira Scarlatelli

; Ferreira, Silvia Moreira Ayub

; Schmidt, Andre

; Melo, Marcelo Dantas Tavares de

; Lima Filho, Moysés Oliveira

; Sposito, Andrei C.

; Brito, Flávio de Souza

; Biolo, Andreia

; Madrini Junior, Vagner

; Rizk, Stephanie Itala

; Mesquita, Evandro Tinoco

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 7 elocation e202400415

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

https://doi.org/10.36660/abc.20240415

Validity of the Brazilian online version of the Sexual Desire Inventory 2
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Cartagena-Ramos, Denisse

; Fuentealba-Torres, Miguel

; Arroyo, Luiz Henrique

; Santos, Daniella Talita dos

; Rebustini, Flávio

; Lara, Lúcia Alves Silva

; Arcêncio, Ricardo Alexandre

; Nascimento, Lucila Castanheira

Revista da Associação Médica Brasileira

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2024, Volume 70 Nº 7 elocation e20240362

Resumo: En | Texto: En | PDF: En

SUMMARY The Sexual Desire Inventory 2 is a self-report instrument for assessing sexual desire in men and women. In Brazil, there is no validated sexual desire self-report for the adult population. Objective: The aim of this study was to determine the evidence of validity for the content and construct of the Brazilian online version of the Sexual Desire Inventory 2. Methods: This was a cross-sectional study with Brazilian men and women. The sample size was calculated using the criterion of more than 20 participants per item. The invitation to participate in the study was conducted online by the platform Survey Monkey®. The Sexual Desire Inventory 2 was evaluated for content, construct, reliability, and invariance. Results: A total of 818 female and male adults participated in the study. The two-dimensional factorial solution represented 71% of the total variance explained by the model, and the factorial loads of the model were ≥0.40; commonalities presented values ≥0.23. Reliability was measured by the coefficients of Cronbach's alpha with a total score of 0.87, McDonald's of 0.87, Omega, and greatest lower bound with a total score of 0.95. The metric invariance was tested for the sex variables ΔCFI (comparative fit index) and ΔRMSEA (root mean square error of approximation) with a total score of 0.01. Conclusion: The analyses indicate evidence of robust validity in the Brazilian online version of the Sexual Desire Inventory 2. selfreport self report women Brazil population Objective Methods crosssectional cross sectional item Monkey Monkey® reliability Results 81 twodimensional two dimensional 71 ≥0.40 040 0 40 023 23 ≥0.23 Cronbachs Cronbach s 087 87 0.87 McDonalds McDonald Omega 095 95 0.95 comparative index root approximation 001 01 0.01 Conclusion 8 7 ≥0.4 04 4 02 ≥0.2 08 0.8 09 9 0.9 00 0.0 ≥0. 0. ≥0 ≥

https://doi.org/10.1590/1806-9282.20240362

Lipectomia e lipoaspiração seriadas para manejo de síndrome de Madelung: A respeito de um caso Madelung
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SILVA, PEDRO HENRIQUE DE ARAÚJO

; SÁ, JAIRO ZACCHÊ DE

; MOTTA, FLÁVIO JOSÉ TEIXEIRA ROCHA ATAÍDE DA

; CASTRO, HELENA GABRIELE ALVES

; AMORIM, VINICYUS EDUARDO MELO

; VIANA, ANDRESA DOS SANTOS

; BRAVIN, LARISSA CARARETO

; PONTUAL, PEDRO HENRIQUE

Revista Brasileira de Cirurgia Plástica

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2024, Volume 39 Nº 2 elocation e0870

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Madelung’s disease is characterized by the symmetric and diffuse accumulation of adipose tissue with slow and progressive tumor growth. In this case report, a patient with this syndrome was treated at Hospital das Clínicas, in Recife, PE, to reduce the lipomatous content through a lipectomy. The patient presented large masses of elastic adipose tissue around the neck and supraclavicular region and the therapeutic proposal consisted of a two-stage surgery, with liposuction and anterior cervical lipectomy, followed by liposuction and posterior cervical lipectomy. Before surgery, a cardiological opinion was requested, which indicated an intermediate risk but did not contraindicate the procedure. Four days after surgery, the patient presented bruises and peripheral edema in the cervical surgical wound but was asymptomatic. Lipectomy and liposuction techniques are considered the most effective treatment methods for Madelung disease. However, the choice of surgery should be based on a comprehensive assessment of the severity of the disease, location of the mass, and patient expectations, as both techniques have advantages and disadvantages. Madelungs s growth report Clínicas Recife PE lipectomy twostage two stage requested procedure asymptomatic However mass expectations disadvantages

RESUMO A doença de Madelung é caracterizada pelo acúmulo simétrico e difuso de tecido adiposo com crescimento tumoral lento e progressivo. Neste relato de caso, um paciente portador dessa síndrome foi atendido no Hospital das Clínicas, em Recife, PE, com o objetivo de realizar uma redução do conteúdo lipomatoso através de lipectomia. O paciente apresentava volumosas massas de tecido adiposo elástico ao redor do pescoço e região supraclavicular e a proposta terapêutica consistiu em uma cirurgia em dois tempos, com lipoaspiração e lipectomia cervical anterior, seguida de lipoaspiração e lipectomia cervical posterior. Antes da cirurgia, foi solicitado um parecer cardiológico, que indicou um risco intermediário, mas não contraindicou o procedimento. Após 4 dias da cirurgia, o paciente apresentou equimoses e edema periférico na ferida operatória cervical, porém estava assintomático. As técnicas de lipectomia e lipoaspiração são consideradas os métodos de tratamento mais eficazes para a doença de Madelung. No entanto, a escolha da cirurgia deve ser baseada em uma avaliação abrangente da gravidade da doença, localização da massa e expectativas do paciente, uma vez que ambas as técnicas possuem vantagens e desvantagens. progressivo caso Clínicas Recife PE tempos anterior posterior cardiológico intermediário procedimento assintomático entanto desvantagens

https://doi.org/10.5935/2177-1235.2024rbcp0870-pt

10.

Avaliação de Fatores Clínicos na Evolução de Pacientes Transplantados Cardíacos: Estudo de Coorte Retrospectivo Unicêntrico Cardíacos
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Paula, Gabriela Vieira de

; Costa, Adriele Fogaça

; Viana, Nathalia Alves

; Cyrino, Claudia Maria Silva

; Felicio, Marcello Laneza

; Brito, Flávio de Souza

; Ponce, Daniela

Brazilian Journal of Transplantation

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2024, Volume 27 elocation e2824

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Introduction: After heart transplantation (HTx), some patients continue to experience disproportionately high mortality. Objectives: To investigate which clinical variables are associated with survival after HTx. Methods: Retrospective, single-center cohort study with 55 patients undergoing HTx from May 2019 to April 2023. Results: Logistic regression identified, as variables associated with death, the increase in creatinine in the immediate postoperative period (POI) (p = 0.0067), pulmonary vascular resistance (RVP) (p = 0.0185) and pulmonary artery systolic pressure (PSAP) before HTx (p = 0.0415). When constructing the ROC curve (receiver operating characteristic curve) with the delta of the increase in creatinine in the first 24 postoperative hours, the cutoff point was 0.35 mg/dL, the sensitivity was 0.76, and the specificity was 0. 90. In the ROC curve for PVR, the cutoff point was 2.23 Woods units (WU), with sensitivity of 0.79 and specificity of 0.72. In the ROC curve for PSAP, the cutoff point was 40.50 mmHg, with a sensitivity of 0.89 and a specificity of 0.86. Conclusion: An increase in creatinine to a value greater than or equal to 0.35 mg/dL in the first 24 hours, PSAP with values greater than 40.5 mmHg and an increase in RVP to a value above 2.23 WU are associated with increased rates of hospital mortality after HTx. Introduction HTx, , (HTx) Objectives Methods Retrospective singlecenter single center 5 201 2023 Results identified death POI (POI p 0.0067, 00067 0.0067 0 0067 0.0067) (RVP 0.0185 00185 0185 (PSAP 0.0415. 00415 0.0415 . 0415 0.0415) receiver 2 hours 035 35 0.3 mgdL mg dL 076 76 0.76 90 PVR 223 23 2.2 WU, (WU) 079 79 0.7 072 72 0.72 4050 40 50 089 89 0.8 086 86 0.86 Conclusion 405 40. (HTx 20 202 0006 0.006 006 0.018 0018 018 0041 0.041 041 03 3 07 7 9 22 2. (WU 4 08 8 000 0.00 00 0.01 001 01 004 0.04 04 0.0

RESUMO Introdução: Após o transplante cardíaco (TxC), alguns pacientes continuam a apresentar mortalidade desproporcionalmente alta. Objetivos: Investigar quais variáveis clínicas estão associadas à sobrevida após o TxC. Métodos: Estudo do tipo coorte retrospectivo, unicêntrico, com 55 pacientes submetidos a TxC no período de maio de 2019 a abril de 2023. Resultados: A regressão logística identificou, como variáveis associadas ao óbito, o aumento da creatinina no pós-operatório imediato (POI) (p = 0,0067), a resistência vascular pulmonar (RVP) (p = 0,0185) e a pressão sistólica da artéria pulmonar (PSAP) prévios ao TxC (p = 0,0415). Ao construir a curva ROC (receiver operating characteristic curve) com o delta do aumento da creatinina nas primeiras 24 horas do pós-operatório, o ponto de corte foi de 0.35 mg/dL, a sensibilidade de 0,76 e a especificidade de 0,90. Na curva ROC para a RVP, o ponto de corte foi de 2,23 unidades Woods (WU), com sensibilidade de 0,79 e especificidade de 0,72. Na curva ROC para a PSAP, o ponto de corte foi de 40,50 mmHg, com sensibilidade de 0,89 e especificidade de 0,86. Conclusão: Aumento da creatinina para valor maior ou igual a 0,35 mg/dL nas primeiras 24 horas, PSAP com valores superiores a 40,5 mmHg e aumento da RVP para valor acima de 2,23 WU estão associados ao aumento das taxas de mortalidade hospitalar após o TxC. Introdução TxC, , (TxC) alta Objetivos Métodos retrospectivo unicêntrico 5 201 2023 Resultados identificou óbito pósoperatório pós operatório POI (POI p 0,0067, 00067 0,0067 0 0067 0,0067) (RVP 0,0185 00185 0185 (PSAP 0,0415. 00415 0,0415 . 0415 0,0415) receiver curve 2 pósoperatório, operatório, 035 35 0.3 mgdL mg dL 076 76 0,7 090 90 0,90 223 23 2,2 WU, (WU) 079 79 072 72 0,72 4050 40 50 089 89 0,8 086 86 0,86 Conclusão 0,3 405 40, (TxC 20 202 0006 0,006 006 0,018 0018 018 0041 0,041 041 03 3 0. 07 7 0, 09 9 0,9 22 2, (WU 4 08 8 000 0,00 00 0,01 001 01 004 0,04 04 0,0

https://doi.org/10.53855/bjt.v27i1.592_port

11.

Brazilian Psychiatric Association consensus on the ideal infrastructure and team for psychiatric emergency services
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Baldaçara, Leonardo

; Ismael, Flávia

; Kawakami, Daniel

; da Rocha, Gislene Alves

; Calfat, Elie Leal de Barros

; Porto, Deisy Mendes

; Cavalcante, Beatriz Ferroli

; Zaramella, Beatriz Plotegher

; Ribeiro, Flávio Veloso

; dos Santos, Roberto Mendes

; Grudtner, Roberta Rossi

; Tung, Teng Chei

; da Silva, Antônio Geraldo

Brazilian Journal of Psychiatry

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2024, Volume 46 elocation e20243567

Resumo: En | Texto: En | PDF: En

An integral part of Brazil’s public health system, psychiatric emergency services have been instrumental in improving qualified support for crisis situations involving mental disorders in an equitable, universally accessible, and humanized way. The purpose of this article is to present a systematic review and consensus on the infrastructure and the ideal team for psychiatric emergencies services in Brazil. The authors searched electronic databases including MEDLINE (PubMed), SciELO, and Cochrane, in addition to documents from the World Health Organization, the Brazilian Ministry of Health, and other authorities. Of the 6839 manuscripts found, 46 were included. The content analysis summarized consensus statements through the Delphi method, and, after a series of interactive versions, a final report was produced. Models for changing psychiatric emergency services are assessed. It was determined that the emergency care network must be supervised by qualified management, and all health equipment and units must be effectively integrated. Psychiatric emergency services need adequate infrastructure, qualified staff (including a psychiatrist), sufficient consultation and observation space, tools and resources for differential diagnosis, training for all staff members, and communication with the health care network to facilitate referrals following patient discharge. Standardized models should be available to public health managers to guide the development of new services and adjust existing ones, always seeking improvement. The authors propose a model of psychiatric emergency services. Brazils Brazil s system equitable accessible way PubMed, PubMed , (PubMed) SciELO Cochrane Organization authorities 683 found 4 included method versions produced assessed management integrated psychiatrist, psychiatrist psychiatrist) space diagnosis members discharge ones improvement (PubMed 68 6

https://doi.org/10.47626/1516-4446-2024-3567

12.

Validation of Brazilian Version of the Sexual Desire Inventory 2 (SDI-2) SDI2 SDI (SDI-2 (SDI- (SDI
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Cartagena-Ramos, Denisse

; Fuentealba-Torres, Miguel

; Rebustini, Flávio

; Alves, Josilene

; Scholze, Alessandro

; Lara, Lúcia Alves da Silva

; Arcêncio, Ricardo

; Nascimento, Lucila Castanheira

Revista Brasileira de Ginecologia e Obstetrícia

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2024, Volume 46 elocation e-rbgo78

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To traslate and validate of the Brazilian version of the SDI-2. Methods: This was a cross-sectional study. The cultural adaptation considered the stages of initial translation, synthesis of translations, evaluation by a committee of experts from different regions of Brazil, back-translation, and pre-test. The content validity and psychometric proprieties was assessed. Results: Ten specialists participated in the cultural adaptation of the SDI-2. The content validity showed a Content Validity Ratio (CVR) ≥ 0.75 (p = 0.05). A total of 674 subjects participated in the field study. The Exploratory Factorial Analysis (EFA) presented factor loads ≥ 0.445, and commonalities ≥ 0.40; and two dimensions represented 77% of the total variance explained. The Confirmatory Factorial Analysis CFA presented X2/df = 4.265; the Root Mean Square Error of Approximation RMSEA = 0.110; the Non-Normed Fit Index NNFI = 0.946; the Comparative Fit Index (CFI) = 0.963; the Goodness of Fit Index GFI = 0.986; and the Adjusted Goodness of Fit Index AGFI = 0.979 for a two-factor model. The coefficient values for the total SDI-2 score were 0.91 for Cronbach's alpha, 0.91 for McDonald's Omega, and 0.97 for the Greatest Lower Bound GLB coefficients. The invariance between sexes was 0.01 for the ΔCFI and ΔRMSEA, showing model stability for these two populations. Conclusion: The Brazilian version of the SDI-2 is self-report, valid, reliable and invariant across sex. Objective SDI2. SDI2 SDI 2. 2 Methods crosssectional cross sectional study translation translations Brazil backtranslation, backtranslation back back-translation pretest. pretest pre test. test pre-test assessed Results CVR (CVR 075 0 75 0.7 p 0.05. 005 0.05 . 05 0.05) 67 EFA (EFA 0445 445 0.445 0.40 040 40 77 explained X2df Xdf X2 df X 4.265 4265 4 265 0.110 0110 110 NonNormed Non Normed 0.946 0946 946 CFI (CFI 0.963 0963 963 0.986 0986 986 0979 979 twofactor SDI- 091 91 0.9 Cronbachs Cronbach s alpha McDonalds McDonald Omega 097 97 coefficients 001 01 0.0 ΔRMSEA populations Conclusion selfreport, selfreport self report, report self-report valid sex 07 7 0. 00 6 044 44 0.44 0.4 04 4.26 426 26 0.11 011 11 0.94 094 94 0.96 096 96 0.98 098 98 09 9 4.2 42 0.1 1 4.

https://doi.org/10.61622/rbgo/2024rbgo78

13.

PARALLELIZATION OF SHORTEST PATH CLASS ALGORITHMS: A COMPARATIVE ANALYSIS ALGORITHMS
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Souza, Flávio Henrique Batista de

; Abreu, Marcos Henrique Gonçalves

; Trindade, Paulo Ricardo Fonseca

; Fernandes, Gustavo Alves

; Carvalho, Luiz Melk de

; Couto, Braulio Roberto Gomes Marinho

; Rodrigues, Diva de Souza e Silva

Pesquisa Operacional

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2023, Volume 43 elocation e272130

Resumo: En | Texto: En | PDF: En

ABSTRACT The problem of finding the shortest path between a source and a destination node, commonly represented by graphs, has several computational algorithms as an attempt to find what is called the minimum path. Depending on the number of nodes in-between the source and destination, the process of finding the shortest path can demand a high computational cost (with polynomial complexity). A solution to reduce the computational cost is the use of the concept of parallelism, which divides the algorithm tasks between the processing cores. This article presents a comparative analysis of the main algorithms of the shortest path class: Dijkstra, Bellman-Ford, Floyd-Warshall and Johnson. The performance of each algorithm was evaluated considering different parallelization approaches and they were applied on general and open-pit mining databases present in the literature. The experimental results showed an improvement in performance of about 55% on the execution time depending on the chosen parallelization point. node graphs inbetween with complexity. complexity . complexity) parallelism cores class Dijkstra BellmanFord, BellmanFord Bellman Ford, Ford Bellman-Ford FloydWarshall Floyd Warshall Johnson openpit open pit literature 55 point 5

https://doi.org/10.1590/0101-7438.2023.043.00272130

14.

Validation of the single-platform ISHAGE protocol for enumeration of CD34+ hematopoietic stem cells in umbilical cord blood in a Brazilian center
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Pedrosa de Lira de Morais, Carla Cristina

; Dias Alves Pinto, Juliana

; Wagner de Souza, Karen

; Izu, Marina

; Fernando da Silva Bouzas, Luis

; Henrique Paraguassú-Braga, Flávio

Hematology, Transfusion and Cell Therapy

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Jan 2022, Volume 44 Nº 1 Páginas 49 - 55

Resumo: En | Texto: En | PDF: En

Abstract Background This study aims to validate the single-platform method for enumeration of CD34+ cells, by comparing the performance of two different commercial kits, as well as to evaluate the efficiency of the AccuriTM C6 cytometer in providing direct counts of absolute cell numbers. Method We evaluated 20 samples from umbilical cord blood (UCB), comparing the two different methodologies for enumeration of CD34+ cells: single and dual-platform. For the assessment of the single-platform, Procount and SCE kits were used, both of which use fluorescent beads as a counting reference to obtain absolute CD34+ cells numbers. Moreover, after the acquisition of samples in flow cytometer AccuriTM C6, following the protocol established for each kit, the number of CD34+ cells was recalculated, considering the cell count provided by the AccuriTM C6. Main Results In our analysis, the results showed a strong correlation between the number of CD34+ cells/μL (r2 = 0.77) when comparing the SCE kit and the current dual-platform method. On the other hand, the comparison between Procount kit and dual-platform results showed a moderate correlation for the number of CD34+/μL cells (r2 = 0.64). Conclusion Our results showed that the AccuriTM C6 flow cytometer can be used safely, applying both the dual and single platform analysis strategy. Considering the ISHAGE protocol-based single-platform approach, as the most appropriate methodology for CD34+ cells enumeration, our results demonstrated that the SCE kit has great potential for national standardization of UCB samples analysis methodology.

https://doi.org/10.1016/j.htct.2020.09.151

15.

Heterogeneous persistence of Mycobacterium leprae in oral and nasal mucosa of multibacillary patients during multidrug therapy
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Neumann, Arthur da Silva

; Fontes, Amanda Nogueira Brum

; Lopes, Márcia Quinhones Pires

; Suffys, Philip Noel

; Moraes, Milton Ozório

; Lara, Flávio Alves

Memórias do Instituto Oswaldo Cruz

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2022, Volume 117 elocation e220058

Resumo: En | Texto: En | PDF: En

BACKGROUND Leprosy is curable by multidrug therapy (MDT) treatment regimen ranging from six to 12 months. The variable levels of tolerance and adherence among patients can, however, result in treatment failure and the emergence of drug-resistant strains. OBJECTIVES Describe the impact of MDT over Mycobacterium leprae viability in patient’s oral and nasal mucosa along treatment. METHODS Mycobacterium leprae viability was monitored by quantitative polymerase chain reaction (qPCR) quantification of 16S rRNA in lateral and contralateral scrapings of oral and nasal mucosa of 10 multibacillary patients along the initial five months of treatment. FINDINGS The results demonstrated high heterogenicity of M. leprae viability among patients and between nasal and oral samples. Of six patients who presented good adherence and tolerance to the treatment, only four displayed absence of M. leprae viability in both samples three months after the first MDT dose, while for the other two, the absence of M. leprae viability in the oral and nasal cavities was only detected five months after the first dose. MAIN CONCLUSIONS We concluded that qPCR of 16S rRNA for the determination of M. leprae viability in nasal and oral scraping samples could represent an interesting approach to monitor treatment efficacy.

https://doi.org/10.1590/0074-02760220058

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