Neste trabalho, apresento algumas partes da minha dissertação defendida em 2023, onde analiso depoimentos produzidos e compartilhados durante as dinâmicas efetivadas no campo de pesquisa. Realizei observação participante no programa “Território Hip-Hop” da prefeitura de São Paulo – uma iniciativa de política pública conquistada pela militância da cultura Hip-Hop na cidade. Essa imersão permitiu compreender os desenvolvimentos e interações de jovens negros/as e periféricos/as participantes das atividades do programa. Utilizei trechos de rap de artistas como Baco Exu do Blues, Cristal e Djonga para a produção de dados. As músicas foram usadas como provocações, permitindo levantar questões e reflexões, mais do que apenas fornecer respostas definitivas. Organizei um experimento com dois grupos focais e realizei entrevistas semiestruturadas com alguns/as desses/as adolescentes, captando suas perspectivas e conhecimentos situados. Essa abordagem metodológica permitiu uma análise das experiências, das construções de identidades e posicionamentos dos/as jovens, contextualizando suas vivências no cotidiano. Durante a produção e análise dos dados, investiguei as vozes e conhecimentos desses jovens identificados com a cultura Hip-Hop. Busquei compreender os efeitos subjetivos das mensagens de negritude presentes no rap, que descrevem as realidades raciais no Brasil. Desse modo, analisei como essas mensagens influenciam trajetórias e perspectivas de vida, moldando identidades e identificações. As entrevistas e discussões revelaram o rap como uma poderosa ferramenta transformadora que estimula reflexões profundas e transcende a luta contra opressões, sendo um saber realizado pelo corpo e pela voz, representando múltiplas vivências.

In this paper, I present some parts of my dissertation defended in 2023, where I analyze testimonies produced and shared during the dynamics carried out in the research field. I carried out participant observation in the “Território Hip-Hop” program of the city of São Paulo – a public policy initiative achieved by the activism of Hip-Hop culture in the city. This immersion allowed me to understand the dynamics and interactions of young black people and people from the outskirts of the city who participated in the program’s activities. I used rap excerpts from artists such as Baco Exu do Blues, Cristal and Djonga to produce data. The songs were used as provocations, allowing questions and reflections to be raised, rather than just providing definitive answers. I organized an experiment with two focus groups and conducted semi-structured interviews with some of these adolescents, capturing their perspectives and situated knowledge. This methodological approach allowed an analysis of the experiences, identity constructions and positioning of the young people, contextualizing their experiences in everyday life. During the production and analysis of the data, I investigated the voices and knowledge of these young people who identify with Hip-Hop culture. I sought to understand the subjective effects of the messages of blackness present in rap, which describe racial realities in Brazil. In this way, I analyzed how these messages influence life trajectories and perspectives, shaping identities and identifications. The interviews and discussions revealed rap as a powerful transformative tool that stimulates deep reflections and transcends the fight against oppression, being a knowledge carried out by the body and voice, representing multiple experiences.

Resumo O uso de preservativos pode ser influenciado por aspectos psicológicos e socioculturais, que podem ser modulados por atitudes individuais. O objetivo foi propor uma versão em português brasileiro da Short-Form Condom Attitude Scale (Short-Form CAS), descrevendo os procedimentos de tradução, adaptação transcultural e avaliação das propriedades psicométricas em uma amostra de universitários. Trata-se de estudo transversal com estudantes matriculados na Universidade de São Paulo (USP), Campus Ribeirão Preto (n = 491; 61,2% feminino; média de idade: 22 anos; desvio-padrão: quatro anos). Foi realizada análise fatorial confirmatória. O modelo unifatorial com sete itens apresentou boa validade fatorial e confiabilidade, sugerindo ser a melhor solução fatorial para a Short-Form CAS. Há poucos estudos sobre os fatores comportamentais associados ao uso de preservativos em populações-chave, o que pode ser influenciado pela falta de instrumentos. A principal contribuição deste estudo foi propor uma versão simples e adaptada transculturalmente da Short-Form CAS com algumas propriedades psicométricas verificadas. Uma vez que o uso de preservativos é um componente do comportamento sexual de risco, a escala se apresenta como uma nova opção para futuros estudos na população brasileira. socioculturais individuais ShortForm Short Form CAS, , CAS) tradução universitários Tratase Trata USP, USP (USP) n 491 612 61 2 61,2 feminino idade anos desviopadrão desvio padrão desvio-padrão anos. . anos) confirmatória confiabilidade populaçõeschave, populaçõeschave populações chave, chave populações-chave instrumentos verificadas risco brasileira (USP 49 6 61, 4

Abstract The condom use can be influenced by psychological and sociocultural aspects, which can be modulated by individual’s attitudes. The aim was to propose a Brazilian Portuguese version of the Short-Form Condom Attitude Scale (Short-Form CAS), describing all procedures of translation, transcultural adaptation, and psychometric properties evaluation when applied to undergraduate students. A cross sectional study was conducted among students enrolled at University of São Paulo (USP), Campus Ribeirão Preto (n = 491; 61.2% female; average age: 22 years; standard deviation: four years). Confirmatory factor analysis was performed. A one-factor model with seven items exhibited good factorial validity and reliability, suggesting to be a better factorial solution of the Short-Form CAS in the sample. Few studies have been carried out on the behavioral factors associated with condom use in key populations, which can be exacerbated by a lack of appropriate scales. Therefore, the main contribution of the present study was to propose a simplified and transculturally adapted version of the Short-form CAS with some psychometric properties verified. Since the use of condoms is a component of the study of sexual risk behavior, this scale might be an option to be applied in various Brazilian population segments for this purpose. aspects individuals individual s attitudes ShortForm Short Form CAS, , CAS) translation adaptation USP, USP (USP) n 491 612 61 2 61.2 female age years deviation years. . years) performed onefactor one reliability sample populations scales Therefore Shortform form verified behavior purpose (USP 49 6 61. 4

Abstract Objective To present the different aspects that may be involved in the genesis and maintenance of obesity in children and adolescents. Data source Narrative review of articles published in the PubMed, Scielo, Lilacs, Scopus and Google Scholar databases, using the search terms: overweight, obesity, pre-conception, prenatal, infants, schoolchildren, children, and adolescents. The search was conducted in studies written in Portuguese, English and Spanish, including narrative, integrative or systematic reviews, meta-analyses, cross-sectional, case-control and cohort studies, published between 2003 and 2023. Data synthesis A total of 598 studies were initially screened and 60 of them, which showed the main biopsychosocial aspects related to greater risks of excessive adiposity in the pediatric age, were included in the review. The data were presented taking into account the incidence of risk factors and their consequences in six periods: pre-conception, pre-natal, infant, preschool, school age, and adolescence. Conclusions The causal factors described in the scientific literature that have been shown to be related to obesity in childhood and adolescence are presented. adolescents PubMed Scielo Lilacs databases terms overweight preconception, preconception pre conception, conception pre-conception prenatal infants schoolchildren Portuguese Spanish narrative reviews metaanalyses, metaanalyses meta analyses, analyses meta-analyses crosssectional, crosssectional cross sectional, sectional cross-sectional casecontrol case control 200 2023 59 6 them age periods natal, natal pre-natal infant preschool 20 202 5 2

Resumo Introdução: Pacientes com doença renal em estágio terminal (DRET) geralmente enfrentam uma rotina desafiadora de hemodiálise, restrições alimentares e diversos medicamentos, podendo afetar sua função hemodinâmica. Abordagens domiciliares, seguras e não farmacológicas, como a estimulação transcraniana por corrente contínua (ETCC), devem ser combinadas com tratamento convencional. Objetivo: Avaliar segurança e viabilidade da ETCC na pressão arterial e frequência cardíaca em pacientes com DRET em hemodiálise. Método: Estudo paralelo, randomizado, controlado por placebo. Foram incluídos pacientes em hemodiálise por mais de três meses. Os pacientes receberam dez sessões não consecutivas de ETCC de 2mA no córtex motor primário. Cada sessão durou 20 minutos. No início do estudo e após cada uma das dez sessões, a pressão arterial e frequência cardíaca dos pacientes foram medidas a cada hora durante quatro horas. Resultados: Trinta pacientes foram randomizados para grupo ativo ou sham. A diferença média entre grupos foi calculada como valor médio do grupo sham menos valor médio do grupo ativo. Apesar de não haver alterações estatísticas para todos os desfechos considerando as 10 sessões, encontramos diferenças entre os grupos para pressão arterial sistólica –10,93 (–29,1; 7,2), diastólica –3,63 (–12,4; 5,1) e média –6,0 (–16,3; 4,2) e frequência cardíaca 2,26 (–2,5; 7,1). Não encontramos eventos adversos graves. O grupo ativo apresentou valores maiores de pressão arterial em todos os pontos, enquanto a frequência cardíaca foi menor no grupo ativo. Conclusão: ETCC é segura e viável para pacientes com DRET submetidos à hemodiálise. Estudos futuros devem investigar se a ETCC pode potencialmente induzir um efeito hipotensor protetor durante a hemodiálise. Introdução (DRET medicamentos hemodinâmica domiciliares farmacológicas ETCC, , (ETCC) convencional Objetivo Método paralelo randomizado placebo meses mA primário 2 minutos horas Resultados 1 1093 93 –10,9 –29,1 291 29 (–29,1 7,2, 72 7,2 7 7,2) 363 3 63 –3,6 –12,4 124 12 4 (–12,4 5,1 51 5 60 6 0 –6, –16,3 163 16 (–16,3 4,2 42 226 26 2,2 –2,5 25 (–2,5 7,1. 71 7,1 . 7,1) graves pontos Conclusão (ETCC 109 9 –10, –29, (–29, 7, 36 –3, –12, (–12, 5, –6 –16, (–16, 4, 22 2, –2, (–2, –10 –29 (–29 –3 –12 (–12 – –16 (–16 –2 (–2 –1 (–1 (– (

Abstract Introduction: Patients with end-stage renal disease often face a challenging routine of hemodialysis, dietary restrictions, and multiple medications, which can affect their hemodynamic function. Home-based, safe, and nonpharmacological approaches such as transcranial direct current stimulation (tDCS) should be combined with conventional treatment. Objective: To assess the safety and feasibility of tDCS on blood pressure and heart rate in patients with end-stage renal disease undergoing hemodialysis. Method: This is a parallel, randomized, sham-controlled trial. Patients undergoing hemodialysis for more than three months were included. The patients received ten non-consecutive 2mA tDCS sessions on the primary motor cortex . Each session lasted 20 minutes. At baseline and after each of the ten sessions, blood pressure and heart rate of the patients were measured hourly for four hours. Results: Thirty patients were randomized to the active or sham group. The mean difference between the groups was calculated as the mean value of the sham group minus the mean value of the active group. Despite there were no statistical changes for all outcomes considering all 10 sessions, we found differences between groups for systolic –10.93 (–29.1;7.2), diastolic –3.63 (–12.4; 5.1), and mean blood pressure –6.0 (–16.3; 4.2) and hear rate 2.26 (–2.5; 7.1). No serious adverse events were found. The active group showed higher blood pressure values at all points, while heart rate was lower in the active group. Conclusion: tDCS is safe and feasible for patients with end-stage renal disease undergoing hemodialysis. Future studies should investigate whether tDCS could potentially induce a hypotensive protective effect during hemodialysis. Introduction endstage end stage restrictions medications function Homebased, Homebased Home based, based Home-based (tDCS treatment Objective Method parallel shamcontrolled controlled trial included nonconsecutive non consecutive mA 2 minutes hours Results 1 1093 93 –10.9 –29.17.2, 29172 –29.1 7.2 , 29 7 (–29.1;7.2) 363 3 63 –3.6 –12.4 124 12 4 (–12.4 5.1, 51 5.1 5 5.1) 60 6 0 –6. –16.3 163 16 (–16.3 4.2 42 226 26 2.2 –2.5 25 (–2.5 7.1. 71 7.1 7.1) points Conclusion 109 9 –10. 17 –29.17.2 2917 291 –29. 72 7. (–29.1;7.2 36 –3. –12. (–12. 5. –6 –16. (–16. 4. 22 2. –2. (–2. –10 –29.17. –29 (–29.1;7. –3 –12 (–12 – –16 (–16 –2 (–2 –1 –29.17 (–29.1;7 (–1 (– (–29.1; ( (–29.1 (–29. (–29

ABSTRACT: Anticarsia gemmatalis (Lepidoptera: Erebidae) is distributed in tropical and subtropical regions of America, and is an important pest of Fabaceae, such as: soybean, peanut, common bean, cowpea, pea, chickpea and kudzu. In soybean, the velvet bean caterpillar is important due to the plant defoliation in their larval stage. This study evaluated soybean cultivars as source of resistance to A. gemmatalis by antixenosis (attractiveness and non-preference for feeding) and antibiosis (biological parameters of the insect). The parameters evaluated were: antixenosis: attractiveness and non-preference, dry mass consumed and attractiveness index and antibiosis: duration of larval and pupal stages, adult longevity, total cycle, larval and pupal weights and larval, pupal and total viability. Considering antixenosis and antibiosis the least suitable cultivars for A. gemmatalis were found to be BRS 8383 IPRO, BRS 1074 IPRO, BRS 1061 IPRO, BRS 7180 IPRO, BRS 9383 IPRO, BRS 8980 IPRO and BRS 1003 IPRO due to high mortality in the larval phase. The cultivars BRS 523 and BRS 543 RR “block technology” suggest displays antixenosis and or antibiosis to A. gemmatalis. These cultivars can be used by soybean producers in combination with other control tactics in soybean IPM. ABSTRACT Lepidoptera (Lepidoptera Erebidae America Fabaceae peanut cowpea pea kudzu stage A nonpreference non preference feeding biological insect. insect . insect) nonpreference, preference, stages longevity cycle viability 838 107 106 718 938 898 100 phase 52 54 block technology IPM 83 10 71 93 89 5 8 1 7 9

RESUMO: Anticarsia gemmatalis (Lepidoptera: Erebidae) está distribuída nas regiões tropicais e subtropicais da América, trata-se de importante praga de Fabaceae, como: soja, amendoim, feijão, feijão-caupi, ervilha, grão de bico e kudzu. Na soja, a lagarta-da-soja é importante devido à desfolha da planta em sua fase larval. O objetivo deste trabalho foi avaliar cultivares de soja como fonte de resistência a A. gemmatalis por antixenose (atratividade e não-preferência para alimentação) e antibiose (parâmetros biológicos do inseto). Os parâmetros avaliados foram: antixenose: atratividade e não-preferência, massa seca consumida e índice de atratividade e antibiose: duração dos estágios larval e pupal, longevidade de adultos, ciclo total, peso larval e pupal e viabilidade larval, pupal e total. Na antixenose e antibiose os cultivares menos favoráveis a A. gemmatalis foram: BRS 8383 IPRO, BRS 1074 IPRO, BRS 1061 IPRO, BRS 7180 IPRO, BRS 9383 IPRO, BRS 8980 IPRO e BRS 1003 IPRO devido à alta mortalidade larval. Os cultivares BRS 523 e BRS 543 RR “Tecnologia block” apresentaram antixenose e/ou antibiose a A. gemmatalis. Essas cultivares podem serem utilizadas por produtores de soja em combinação com outras táticas de controle no MIP. RESUMO Lepidoptera (Lepidoptera Erebidae América tratase trata se Fabaceae amendoim feijão feijãocaupi, feijãocaupi caupi, caupi feijão-caupi ervilha kudzu lagartadasoja lagarta A nãopreferência não preferência alimentação inseto. inseto . inseto) foram nãopreferência, preferência, adultos total 838 107 106 718 938 898 100 52 54 Tecnologia block eou ou MIP 83 10 71 93 89 5 8 1 7 9

ABSTRACT: The current production of major crops, such as Glycine max L., has become increasingly adept on the use of bio-inputs, such as application of plant growth-promoting inocula. However, the evaluation of the potential of bacterial isolates from soils with different time histories of agricultural use are still scarce, and methods for isolation and testing of multifunctional microorganisms need to be continuously innovated and improved. Thus, we used G. max bait plants to attract rhizobacteria from soils obtained from three areas with different time histories of soybean cultivation. We evaluated the influence of the management and characteristics of soils on the phosphate-solubilizing bacterial population. We then tested the multifunctional potential of the isolated rhizobacteria for calcium phosphate (CaHPO4) and iron phosphate (FePO4) solubilization, considering their potential as microbial inoculants in the future. The use of bait plants enabled the isolation of 139 phosphate solubilizing rhizobacteria, including four strains with multifunctional potential. The largest number of solubilizing bacteria was obtained from the interaction of bait plants with soil from an area with a history of soybean cultivation for thirty consecutive years. The high concentration of P, Fe, and K found in the soil were associated with this occurrence. In the in vitro tests, the pH values of the culture media had a moderate negative relationship with the amounts of P made available by the isolates, indicating that other processes besides the availability of organic acids, may underlie the solubilizing action of the isolates. The rhizobacteria SAF9 (Brevibacillus sp.), SAF11 (Brevibacillus sp.), BRC11 (Pseudomonas fluorescens), and SAC36 (Bacillus velezensis) stood out as multifunctional and are indicated within a perspective of obtaining bioinoculants to promote plant growth directly, indirectly, or synergistically, contributing to increase the range of bio-inputs for soybean cultivation and more sustainable agricultural practices. ABSTRACT crops L L. bioinputs, bioinputs bio inputs, inputs growthpromoting promoting inocula However scarce improved Thus G phosphatesolubilizing population CaHPO4 CaHPO (CaHPO4 FePO4 FePO (FePO4 solubilization future 13 years Fe occurrence tests acids SAF Brevibacillus sp., sp sp. , sp.) SAF1 BRC BRC1 Pseudomonas fluorescens, fluorescens fluorescens) SAC SAC3 Bacillus velezensis directly indirectly synergistically practices (CaHPO (FePO 1

RESUMO: A produção atual de grandes culturas, como Glycine max L. tem se mostrado cada vez mais adepta da utilização de bioinsumos, como a aplicação de inóculos promotores do crescimento vegetal. No entanto, avaliações do potencial de isolados bacterianos de solos com diferentes históricos de tempo de uso agrícola ainda são escassos e os métodos para isolamento e testagem de micro-organismos multifuncionais precisam ser continuamente inovados e melhorados. Assim, usamos plantas iscas de G. max para atrair rizobactérias de solos obtidos de três áreas com diferentes históricos de cultivo de soja. Avaliamos a influência do manejo e das características dos solos sobre a população de bactérias solubilizadoras de fosfato. Em seguida, testamos o potencial multifuncional das rizobactérias isoladas para solubilização de fosfato de cálcio (CaHPO4) e fosfato de ferro (FePO4), considerando seu potencial como inoculantes microbianos no futuro. O uso de plantas iscas permitiu o isolamento de 139 rizobactérias solubilizadoras de fosfato, incluindo quatro cepas com potencial multifuncional. O maior número de bactérias solubilizadoras foi obtido a partir da interação das plantas-isca com o solo de uma área com histórico de cultivo de soja por trinta anos consecutivos. Características como a alta concentração de P, Fe e K neste solo, estiveram associadas a esta ocorrência. Nos testes in vitro, os valores de pH dos meios de cultivo se correlacionaram negativamente, mas de forma moderada com as quantidades de P disponibilizados pelos isolados, indicando que outros processos, além da disponibilização de ácidos orgânicos podem estar subjacentes à ação solubilizadora dos isolados. As rizobactérias SAF9 (Brevibacillus sp.), SAF11 (Brevibacillus sp.), BRC11 (Pseudomonas fluorescens) e SAC36 (Bacillus velezensis) se destacaram como multifuncionais e são indicadas dentro de uma perspectiva de obtenção de bioinoculantes para promoção do crescimento vegetal de forma direta, indireta ou sinérgica, contribuindo para aumentar a gama de bioinsumos destinados à cultura da soja e para práticas agrícolas mais sustentáveis. RESUMO culturas L entanto microorganismos micro organismos melhorados Assim G seguida CaHPO4 CaHPO (CaHPO4 FePO4, FePO4 FePO , (FePO4) futuro 13 plantasisca isca consecutivos ocorrência vitro negativamente processos SAF Brevibacillus sp., sp sp. sp.) SAF1 BRC BRC1 Pseudomonas fluorescens SAC SAC3 Bacillus velezensis direta sinérgica sustentáveis (CaHPO (FePO4 1 (FePO

Abstract In this paper, we use a Bayesian method to estimate the effective reproduction number ( R ( t )), in the context of monitoring the time evolution of the COVID-19 pandemic in Brazil at different geographic levels. The focus of this study is to investigate the similarities between the trends in the evolution of such indicators at different subnational levels with the trends observed nationally. The underlying question addressed is whether national surveillance of such variables is enough to provide a picture of the epidemic evolution in the country or if it may hide important localized trends. This is particularly relevant in the scenario where health authorities use information obtained from such indicators in the design of non-pharmaceutical intervention policies to control the epidemic. A comparison between R ( t ) estimates and the moving average (MA) of daily reported infections is also presented, which is another commonly monitored variable. The analysis carried out in this paper is based on the data of confirmed infected cases provided by a public repository. The correlations between the time series of R ( t ) and MA in different geographic levels are assessed. Comparing national with subnational trends, higher degrees of correlation are found for the time series of R ( t ) estimates, compared to the MA time series. Nevertheless, differences between national and subnational trends are observed for both indicators, suggesting that local epidemiological surveillance would be more suitable as an input to the design of non-pharmaceutical intervention policies in Brazil, particularly for the least populated states. , )) COVID19 COVID 19 COVID-1 nationally nonpharmaceutical non pharmaceutical (MA presented variable repository assessed Nevertheless states COVID1 1 COVID-

ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,

Abstract Background: Vasovagal syncope (VVS) results in impaired quality of life (QoL). The response during the head-up tilt test (HUTT) influences QoL and recurrence. Objectives: To analyze the influence of the type of HUTT response on QoL in patients with VVS and recurrence of events after the exam. Methods: The SF-36 and Impact of Syncope on Quality of Life (ISQL) questionnaires were applied over 12 months after the HUTT. Unpaired Student's t test was used for differences between 2 groups of quantitative data with normal distribution. The recurrence of syncope episodes was analyzed using a Kaplan-Meier curve, and the log-rank test was applied to compare the curves regarding responses to the HUTT. Statistical significance was set at p value < 0.05. Results: We analyzed 82 patients (43.7 years old), 69% with previous recurrence (2.8 prior episodes). Cardioinhibitory response occurred in 46 patients; vasodepressor response occurred in 36, and 85.4% of patients received non-pharmacological treatment after the HUTT. During clinical follow-up, 43.9% had recurrence, mainly young patients (35.7 years; p = 0.002). On the SF-36, the best score was in functional capacity in men (p = 0.04) and patients without prior trauma (p = 0.001). There were lower limitations due to pain in patients without prior trauma (p = 0.003) and patients without prodromes (p = 0.009). On the ISQL, there were better mean scores in men (p = 0.002) and in patients without prior trauma (p = 0.02). Patients with cardioinhibitory response had better SF-36 and ISQL scores (p < 0.001). There was greater VVS recurrence in the cardioinhibitory response group (log-rank p = 0.011; hazard ratio: 8.48; 95% confidence interval: 7.59 to 9.3) from the second to the fourth month, with stabilization in the eighth month after the HUTT, when compared to patients with vasodepressor response. Conclusion: The majority of patients with VVS reproduced during the HUTT under non-pharmacological treatment did not report worsening of QoL during clinical follow-up. Worse QoL was observed in non-young patients and in patients with vasodepressor response, and it was not influenced by recurrence after the HUTT. Background (VVS QoL. . (QoL) headup head up (HUTT Objectives exam Methods SF36 SF 36 SF-3 (ISQL 1 Students Student s distribution KaplanMeier Kaplan Meier curve logrank log rank 005 0 05 0.05 Results 8 43.7 437 43 7 (43. old, old , old) 69 2.8 28 (2. episodes. episodes) 4 854 85 85.4 nonpharmacological non pharmacological followup, followup follow up, follow-up 439 9 43.9 35.7 357 35 (35. 0.002. 0002 0.002 002 SF36, 0.04 004 04 0.001. 0001 0.001 001 0.001) 0.003 0003 003 0.009. 0009 0.009 009 0.009) 0.02. 0.02 02 0.02) 0.011 0011 011 ratio 8.48 848 48 95 interval 759 59 7.5 9.3 93 3 Conclusion followup. up. nonyoung (QoL SF3 SF- 00 0.0 43. (43 6 2. (2 85. 35. (35 000 0.00 0.01 01 8.4 84 75 5 7. 9. 0. (4 ( (3 8.

Solid and liquid fractions of hydrothermally pretreated sugarcane bagasse (SCB) were simultaneously used as substrate of a novel continuous compartmentalized reactor. The effect of four (56, 42, 28, and 14 h) hydraulic retention time (HRT) and three (0.5, 3.0, and 9.0 g L-1) chemical oxygen demand (COD) levels were evaluated on hydrogen (H2) and organic acids production. Higher H2 production and yield (686 mL and 1.63 mol mol-1 carbohydrate, respectively) were obtained under an HRT of 28 h, probably due to the Clostridium and Thermoanaerobacterium metabolisms, which accounted for almost 60% of the microbial relative abundance. Under lower and higher HRT (14 and 56 h, respectively) lactic acid prevailed without hydrogen production. Other value-added chemicals such as citric, valeric and caproic acids were also obtained according to the HRT. From the functional point of view, enzymes from the glycoside hydrolases group (GHs) potentially performed important roles in the lignocellulosic biomass bioconversion. SCB (SCB reactor 56, (56 42 1 h (HRT 0.5, 05 0 5 (0.5 30 3 3.0 90 9 9. L1 L L-1 COD (COD H (H2 686 (68 163 63 1.6 mol1 mol- carbohydrate respectively 2 metabolisms 60 abundance (1 valueadded value added citric view GHs (GHs bioconversion (5 4 0.5 (0. 3. L- (H 68 (6 16 6 1. ( 0. (0

Abstract This cross-sectional study investigated the association of SNPs rs670 (C>T) and rs693 (G>A) with parameters of lipid metabolism and endothelial activation in 167 subjects, including 86 COVID-19 outpatients and 81 healthy subjects (control group) matched for sex and age. Serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), non-high-density lipoprotein cholesterol (non-HDL-c), triglycerides (TG), apolipoproteins (Apo A-I and B), and vascular cell adhesion molecule-1 (VCAM-1) were determined. The SNPs were genotyped by quantitative polymerase chain reaction (qPCR). A p -value<0.05 was assumed. COVID-19 outpatients showed increases in TC (187.0±48.3 vs . 160.8±32.0 mg/dL), LDL-c (110.3±41.5 vs . 98.8±28.2 mg/dL), non-HDL-c (138.3±45.8 vs . 115.6±31.6 mg/dL), TG (139.7±80.3 vs . 84.9±35.1 mg/dL), and Apo A-I (149.5±40.0 vs . 133.3±20.9 mg/dL), along with a high frequency of hypercholesterolemia and hypertriglyceridemia. VCAM-1 levels were double those of the control (682.7±231.8 vs. 299.3±102.9 ng/mL) and a strong predictor of COVID-19 (AUC=0.946). Moreover, VCAM-1 correlated with TC (r = -0.223) and HDL-c (r = -0.225). The decrease in TG and VCAM-1 is predicted by the dominance of the T allele (rs670) and its codominance with the A (rs693) allele in COVID-19 outpatients. COVID-19 has been shown to be associated with dyslipidemias and endothelial activation, and apolipoprotein polymorphisms may influence this. crosssectional cross sectional rs rs67 C>T CT C (C>T rs69 G>A GA G (G>A 16 8 COVID19 COVID 19 COVID-1 group age TC, , (TC) highdensity density HDLc, HDLc HDL c (HDL-c) lowdensity low LDLc, LDLc LDL (LDL-c) nonhighdensity non nonHDLc, nonHDLc (non-HDL-c) TG, (TG) AI I B, B B) molecule1 molecule 1 molecule- VCAM1 VCAM (VCAM-1 determined qPCR. qPCR (qPCR) value<0.05 value005 value 0 05 -value<0.0 assumed 187.0±48.3 1870483 187 48 3 (187.0±48. 1608320 160 32 160.8±32. mg/dL, mgdL mg/dL mg dL mg/dL) 110.3±41.5 1103415 110 41 5 (110.3±41. 988282 98 28 2 98.8±28. 138.3±45.8 1383458 138 45 (138.3±45. 1156316 115 6 31 115.6±31. 139.7±80.3 1397803 139 7 80 (139.7±80. 849351 84 9 35 84.9±35. 149.5±40.0 1495400 149 40 (149.5±40. 1333209 133 20 133.3±20. hypertriglyceridemia VCAM- 682.7±231.8 68272318 682 231 (682.7±231. 29931029 299 102 299.3±102. ng/mL ngmL ng mL AUC=0.946. AUC0946 AUC AUC=0.946 946 (AUC=0.946) Moreover r 0.223 0223 223 -0.223 0.225. 0225 0.225 225 -0.225) (rs670 (rs693 this rs6 COVID1 COVID- (TC (HDL-c (LDL-c (non-HDL-c (TG (VCAM- (qPCR value<0.0 value00 -value<0. 187.0±48. 187048 18 4 (187.0±48 160832 160.8±32 110.3±41. 110341 11 (110.3±41 98828 98.8±28 138.3±45. 138345 13 (138.3±45 115631 115.6±31 139.7±80. 139780 (139.7±80 84935 84.9±35 149.5±40. 149540 14 (149.5±40 133320 133.3±20 682.7±231. 6827231 68 23 (682.7±231 2993102 29 10 299.3±102 AUC094 AUC=0.94 94 (AUC=0.946 0.22 022 22 -0.22 -0.225 (rs67 (rs69 (VCAM value<0. value0 -value<0 187.0±48 18704 (187.0±4 16083 160.8±3 110.3±41 11034 (110.3±4 9882 98.8±2 138.3±45 13834 (138.3±4 11563 115.6±3 139.7±80 13978 (139.7±8 8493 84.9±3 149.5±40 14954 (149.5±4 13332 133.3±2 682.7±231 682723 (682.7±23 299310 299.3±10 AUC09 AUC=0.9 (AUC=0.94 0.2 02 -0.2 (rs6 value<0 -value< 187.0±4 1870 (187.0± 1608 160.8± 110.3±4 1103 (110.3± 988 98.8± 138.3±4 1383 (138.3± 1156 115.6± 139.7±8 1397 (139.7± 849 84.9± 149.5±4 1495 (149.5± 1333 133.3± 682.7±23 68272 (682.7±2 29931 299.3±1 AUC0 AUC=0. (AUC=0.9 0. -0. (rs value< -value 187.0± (187.0 160.8 110.3± (110.3 98.8 138.3± (138.3 115.6 139.7± (139.7 84.9 149.5± (149.5 133.3 682.7±2 6827 (682.7± 2993 299.3± AUC=0 (AUC=0. -0 187.0 (187. 160. 110.3 (110. 98. 138.3 (138. 115. 139.7 (139. 84. 149.5 (149. 133. 682.7± (682.7 299.3 AUC= (AUC=0 - 187. (187 110. (110 138. (138 139. (139 149. (149 682.7 (682. 299. (AUC= (18 (11 (13 (14 682. (682 (AUC (1 (68 ( (6

ABSTRACT Objective: To evaluate the cost-effectiveness of single-tooth rehabilitation options with dental implants associated with a prosthetic crown (I+C) compared to a fixed partial denture (FPD). Material and Methods: A rapid review was carried out to identify the costs (expressed in US$) and effectiveness (expressed through success rate). Bibliographic searches retrieved 1,447 records, of which 19 studies of type randomized clinical trials were selected to collect cost and effectiveness data. Markov economic models were used to simulate hypothetical 15-year cohorts with 2000 patients using cost and effectiveness data from the rapid review under the perspective of private practice. Results: The average costs of I+C and FPD treatments were US$ 3,432.23 and US$ 3,322.52, respectively. The average effectiveness of I+C was 88.33%, with a mean follow-up time of 9.33 years, and FPD had an average yearly success rate of 82.14%, with a mean follow-up time of 11.89 years. The I+C treatment has an incremental cost-effectiveness ratio (RCEI) of US$ 170.88 compared to FPD. Conclusion: Both I+C and FPD rehabilitation options are cost-effective; I+C rehabilitation has a higher cost and greater effectiveness, being the recommended option if the patient with no contraindication. Objective costeffectiveness singletooth single tooth IC I C (I+C . (FPD) Methods expressed US rate. rate) 1447 1 447 1,44 records 15year year 15 200 practice Results 343223 3 432 23 3,432.2 332252 322 52 3,322.52 respectively 8833 88 33 88.33% followup follow up 933 9 9.3 years 8214 82 14 82.14% 1189 11 89 11.8 RCEI (RCEI 17088 170 170.8 Conclusion costeffective effective cost-effective contraindication (FPD 144 44 1,4 20 34322 43 2 3,432. 33225 32 5 3,322.5 883 8 88.33 93 9. 821 82.14 118 11. 1708 17 170. 4 1, 3432 3,432 3322 3,322. 88.3 82.1 343 3,43 332 3,322 88. 82. 34 3,4 3,32 3, 3,3

Abstract Biogas production through co-digestion of two or more waste products has garnered increasing attention from researchers seeking to optimize this process. Biogas and methane production increase with the addition of glycerol to agro-industrial wastes during anaerobic biodigestion. However, the utilization of a two-phase process focused on hydrogen production has not been widely explored. This work aims to evaluate two-phase anaerobic biodigestion of cassava wastewater by adding residual glycerol and swine wastewater to enhance hydrogen and methane production. A pilot-scale biodigester was used during the acidogenic phase at 38.5°C, containing 4% glycerol. The effluent was submitted to methanogenic treatment, and the influence of temperature (36.0 to 39.0°C) and sodium bicarbonate concentration (2.0 to 6.0 g L-1) were evaluated. The results indicated that the optimum conditions during the methanogenic phase were 39.0°C with a sodium bicarbonate concentration of 5.0 g L-1. The two-phase biodigestion produced 30.8 mL of (H2) RCOD-1 and 104.5 mL of (CH4) RCOD-1. Thus, the substrates and inoculum used were adequate for the anaerobic biodigestion process, increasing the energetic efficiency of the process due to hydrogen production. codigestion co digestion agroindustrial agro industrial However twophase explored pilotscale pilot scale 385C C 38 5 38.5°C 4 treatment 36.0 360 36 0 (36. 390C 39 2.0 20 2 (2. 60 6 6. L1 L 1 L-1 evaluated 50 5. L1. 1. 308 30 8 30. H2 H (H2 RCOD1 RCOD RCOD- 1045 104 104. CH4 CH (CH4 RCOD1. Thus 3 36. (36 2. (2 L- (H 10 (CH (3 (

RESUMO A produção de biogás por meio da codigestão de dois ou mais resíduos tem atraído atenção crescente de pesquisadores que buscam otimizar esse processo. A adição de glicerol aos resíduos agroindustriais durante a biodigestão anaeróbica tem demonstrado aumentar a produção de biogás e metano. No entanto, a utilização de um processo em duas fases focado na produção de hidrogênio ainda não foi amplamente explorada. Este trabalho visa avaliar a biodigestão anaeróbica em duas fases de águas residuais de mandioca, adicionando glicerol residual e águas residuais suínas para aumentar a produção de hidrogênio e metano. Um biodigestor em escala piloto foi utilizado durante a fase acidogênica a 38,5°C, contendo 4% de glicerol. O efluente foi submetido a tratamento metanogênico, e a influência da temperatura (36,0 a 39,0°C) e da concentração de bicarbonato de sódio (2,0 a 6,0 g L⁻¹) foi avaliada. Os resultados indicaram que as condições ótimas durante a fase metanogênica foram 39,0°C com uma concentração de bicarbonato de sódio de 5,0 g L⁻¹. A biodigestão em duas fases produziu 30,8 mL de H₂ por RCOD⁻¹ e 104,5 mL de CH₄ por RCOD⁻¹. Assim, os substratos e o inóculo utilizados foram adequados para o processo de biodigestão anaeróbica, aumentando a eficiência energética do processo devido à produção de hidrogênio. metano entanto explorada mandioca 385C C 38 5 38,5°C 4 metanogênico 36,0 360 36 0 (36, 390C 39 2,0 20 2 (2, 60 6 6, L⁻¹ L¹ L ¹ avaliada 50 5, 308 30 8 30, H RCOD¹ RCOD RCOD⁻ 1045 104 104, CH Assim 3 36, (36 2, (2 L⁻ 10 (3 ( 1

ABSTRACT: Pythiosis is the disease caused by aquatic oomycetes of the genus Pythium. In dogs the typical course of the disease involves the gastrointestinal tract, characterized by transmural thickening of the stomach or intestines. However, infection by Pythium spp. has only rarely been recognized as a cause of esophagitis in dogs. Thus, the present reports a case of esophageal and gastric pythiosis in an eight-month-old female pit bull dog. The dog was attended at the hospital after two months presenting regurgitation and dyspnea. It was reported that the dog lived in an urban area and had no previous sanitary issues. At clinical examination it was noted that the dog presented crackling sounds at pulmonary auscultation. A support therapy accompanied by antibiotics has been employed; however, 22 days after hospitalization the clinical condition worsened, and the dog died. At necropsy, the wall of the distal segment of the esophagus and the cardia and part of the fundus of the stomach were expanded by a focal extensive irregular intramural annular mass. Additionally, there was a transmural esophageal fistula. At histology, the walls of the esophagus and stomach were extensively expanded by multifocal extensive areas of necrosis, associated with a pyogranulomatous infiltrate and abundant granulation tissue containing multiple negative images of hyphae that were highlighted by silver impregnation (Grocott). Furthermore, immunohistochemistry and PCR for P. insidiosum were both positive in samples of paraffin-embedded esophageal tissue. ABSTRACT tract intestines However spp Thus eightmonthold eight month old dyspnea issues auscultation employed however 2 worsened died necropsy mass Additionally fistula histology necrosis Grocott. Grocott . (Grocott) Furthermore P paraffinembedded paraffin embedded (Grocott

RESUMO: A Pitiose é uma doença causada por oomicetos aquáticos do gênero Pythium. Em cães o curso típico da doença envolve o trato gastrointestinal, caracterizado por espessamento transmural do estômago ou intestinos. No entanto, a infecção por Pythium spp. raramente foi reconhecida como causa de esofagite em caninos. Assim, o presente trabalho tem como objetivo relatar um caso de pitiose esofágica e gástrica em um canino Pit Bull fêmea de oito meses de idade. O cão foi recebido no hospital com histórico de regurgitação e dispneia durante dois meses. Foi relatado que o animal era de um domicílio de área urbana e não possuía histórico pregresso de enfermidades. No exame clínico contatou-se ainda crepitações à ausculta pulmonar. Foi instituído tratamento de suporte e antibioticoterapia, porém após 22 dias de internação, o cão evoluiu para o óbito. Na necropsia, as paredes do segmento distal do esôfago e o cárdia e parte do fundo do estômago estavam expandidos por uma massa anular intramural focalmente extensiva e irregular. Além disso, havia uma fístula esofágica transmural. À histologia, as paredes do esôfago e do estômago apresentavam-se difusamente expandidas por áreas multifocais extensas de necrose, associadas a infiltrado piogranulomatoso, abundante proliferação de fibroblastos imaturos, neovascularização e contendo múltiplas imagens negativas de hifas realçadas pela impregnação por prata (Grocott). Além disso, tanto a imuno-histoquímica como PCR para P. insidiosum foram positivas em amostras de esôfago embebidas em parafina. RESUMO gastrointestinal intestinos entanto spp caninos Assim idade enfermidades contatouse contatou se pulmonar antibioticoterapia 2 internação óbito necropsia irregular disso histologia apresentavamse apresentavam necrose piogranulomatoso imaturos Grocott. Grocott . (Grocott) imunohistoquímica imuno histoquímica P parafina (Grocott

ABSTRACT Resistant genotypes are a valuable tool in integrated pest management programs of insect pests of stored grains. Here, we screened 90 Brazilian common bean genotypes to select promising sources of resistance to Acanthoscelides obtectus. Thus, bean samples were infested with newly emerged insects, and the number of eggs, emerged insects, developmental time, and larval viability were assessed in a no-choice test. Genotypes IPR Garça, CHIR 13, IAC Harmonia, CHIR 20, IAC Boreal, and CHIP 312 showed low oviposition. Genotypes IPR Quero-Quero, BRS Notável, CHIC 61 - Cariocão, BRS Ametista, IPR Uirapuru, IAC Imperador, Avaluna, CHP 04-241A-212 - Guapo B. × Uirapuru, CHIB 06, SCS 206 - Potência, CHC 01-175-1 - Campeiro × IAC Tibatã, CHP 01-182-48 - Uirapuru × Campeiro, UEM 266, CHC 04-233-2 - Siriri × Horizonte, CHV 17-64, SCS 205 - Riqueza, CHP 01-238-80 - MN 13337, SM 1510 - preto, BRS Radiante, CHIB 18, CHIR 14, CAV 17 EFM 008, CHIR 04, IPR Campos Gerais, CHV 05-268-02, LP 13-624 - preto, Linhagem 110 - IAC, CHP 01-182-12 - Uirapuru × Campeiro, LP 13-84 - carioca, BRS Esteio, CHV 17-635, CHB 15-518, Arcelina 1, IPR Tuiuiu, SCS 204 - Predileto, TB - 17-02, BRS Estilo, SM 0511 - cavalo preto, Pérola, IPR Tangará, and CNFRj - 15411 reduced oviposition, the number of emerged adults, and larval viability, suggesting antixenosis and/or antibiosis. Thus, these genotypes are promising sources of resistance factors and can be used in breeding programs to obtain lines of common beans resistant to A. obtectus. grains Here 9 obtectus Thus insects eggs time nochoice no choice test Garça 13 Harmonia 20 Boreal 31 oviposition QueroQuero, QueroQuero Quero Quero, Quero-Quero Notável 6 Cariocão Ametista Imperador Avaluna 04241A212 A 04 241A 212 04-241A-21 B 06 Potência 011751 01 175 1 01-175- Tibatã 0118248 182 48 01-182-4 266 042332 233 2 04-233- Horizonte 1764, 1764 64, 64 17-64 Riqueza 0123880 238 80 01-238-8 13337 151 preto Radiante 18 14 008 Gerais 0526802, 0526802 05 268 02, 02 05-268-02 13624 624 13-62 11 0118212 12 01-182-1 1384 84 13-8 carioca Esteio 17635, 17635 635, 635 17-635 15518, 15518 15 518, 518 15-518 Tuiuiu Predileto 1702, 1702 17-02 Estilo 051 Pérola Tangará 1541 adults andor or antibiosis 3 04241A21 0 21 04-241A-2 01175 01-175 011824 4 01-182- 26 04233 23 04-233 176 17-6 012388 8 01-238- 1333 00 052680 05-268-0 1362 62 13-6 011821 138 13- 1763 63 17-63 1551 51 15-51 170 17-0 154 04241A2 04-241A- 0117 01-17 01182 01-182 0423 04-23 17- 01238 01-238 133 05268 05-268- 136 155 5 15-5 04241A 04-241A 011 01-1 0118 01-18 042 04-2 0123 01-23 0526 05-268 15- 01- 04- 012 01-2 052 05-26 05-2 05-