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Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives Discovery Photosensitizers
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Oliveira, Douglas D. S.
; Lapierre, Thibault J. W. Jacques Dit
; Silva, Fernanda C.
; Cunha, Ieda V.
; Souza, Rafael A. C.
; Matos, Patrícia A.
; Almeida, Gustavo M.
; Oliveira, Carolina G.
; Araújo, Thaise G.
; Tsubone, Tayana M.
; Rezende Jr., Celso O.
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
Cancer is one of the major causes of death worldwide, and breast cancer is the most prevalent and deadly type among women. Despite the side effects and the phenomena of chemoresistance associated with the drugs involved, chemotherapy remains the main therapeutic strategy to combat and control breast cancer. Therefore, several new classes of compounds against breast cancer have been explored, in an effort to identify new drug candidates with alternative mechanisms of action. The principal results of such exploration, focusing on caged xanthones, thiosemicarbazones and photosensitizers, are presented in this review, along with the main aspects of the drug discovery process against breast cancer. More specifically, the design, structure-activity relationship investigations and anti-breast cancer properties of these three classes are described and discussed in this work. worldwide women involved Therefore explored action exploration xanthones photosensitizers review specifically design structureactivity structure activity antibreast anti work
2.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
3.
Use of silicon or carbonitriding interface in the adhesion of Ag-DLC film on titanium alloy: a comparative study AgDLC Ag DLC alloy
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Oliveira, Adriano de
; Silva Sobrinho, Argemiro S. da
; Leite, Douglas M. G.
; J. Neto, Jonas
; Gonçalves, Rodolfo L. P.
; Massi, Marcos
.
REM - International Engineering Journal
- Métricas do periódico
Abstract A Hollow Cathode Plasma Enhanced Chemical Vapor Deposition (HC-PECVD) reactor was used to deposit silver doped Diamond-Like Carbon (Ag-DLC) films on Ti6Al4V alloy employing two methodologies: i) producing a silicon interlayer, using tetramethylsilane (TMS) as silicon precursor, varying the argon flow of the hollow cathode; and ii) carbonitriding the substrate. Profilometry, Raman, and Secondary Ion Mass Spectrometry (SIMS), as well as nanohardness, micro-scratch, scratch, and VDI 3198 indentation tests were used to evaluate the characteristics of the films and their adhesion on the substrates. The results demonstrated that the argon flow can be used for tuning the Ag-DLC film’s hardness, toughness, and adherence on silicon interlayers. The carbonitriding process, in turn, provided an improvement in the film toughness compared with non-carbonitrided samples. Considering the lower cost and easier handling of N2 compared to the silicon precursors commonly available (TMS, HDMSO, SiH4, etc.), the carbonitriding process proved more appropriate to improve the adhesion of the Ag-DLC films on the Ti6Al4V alloy. HCPECVD HC PECVD (HC-PECVD DiamondLike Diamond Like AgDLC Ag DLC (Ag-DLC TiAlV Ti Al V methodologies i interlayer TMS (TMS precursor cathode ii substrate Profilometry Raman SIMS, SIMS , (SIMS) nanohardness microscratch, microscratch micro scratch micro-scratch 319 substrates s hardness interlayers turn noncarbonitrided non carbonitrided samples N TMS, HDMSO SiH4 SiH etc., etc etc. etc.) (SIMS 31 3
4.
ABORDAGEM DA EDUCAÇÃO AMBIENTAL NO ENSINO DE QUÍMICA: UMA ANÁLISE A PARTIR DE ARTIGOS PUBLICADOS NA REVISTA QUÍMICA NOVA NA ESCOLA (QNEsc) QNEsc (QNEsc
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Aprigio, Sergiana S. de Oliveira
; Nascimento, Maria Vitória L.
; Cantanhede, Leonardo B.
; Cantanhede, Severina C. da Silva
; Trindade Junior, Osiel C. da
; Barbosa, Douglas R. e Silva
; Araújo, Lidiane da Silva
.
The knowledge of chemistry connected to environmental problems and sustainable development can provide an opportunity for dynamic, investigative, and directed teaching towards the recognition of chemistry itself as a science and social practice. From this perspective, this work aimed to investigate how discussions involving topics related to environmental education are conducted by researchers and/or professionals in chemical education, based on articles published in the journal Química Nova na Escola (QNEsc). The selection of articles was made considering publications from QNEsc between the years 1995 and 2022, focusing on terms such as environmental education, environment, pollution, environmental aspects, sustainability, and sustainable development present in the title, abstract, and/or keywords of the published articles. The selected texts were analyzed using Iramuteq software, applying correspondence factorial analysis (CFA), hierarchical descendant classification (HDC), similarity analysis, and word cloud using their respective abstracts. The data show that topics such as water, pesticides, waste, and plastic materials (polymers) were the most addressed by the publications, indicating a path that seeks to present and discuss proposals that value the need for sustainable actions, addressing environmental issues that directly impact the way humans use natural resources in the present and future. dynamic investigative practice perspective andor or QNEsc. . (QNEsc) 199 2022 environment pollution aspects sustainability title abstract software CFA, CFA , (CFA) HDC, HDC (HDC) abstracts water pesticides waste polymers (polymers actions future (QNEsc 19 202 (CFA (HDC 1 20 2
5.
Detection of Eyebolt Faults Using a Random Forest Ensemble Model Based on Multiple High-Frequency Electromagnetic Parameters HighFrequency High Frequency
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Silva Filho, H. V. H.
; Santos, R.G. M. dos
; Barbosa, Douglas C. P.
; Melo, M. T. de
; Novo, Lauro R. G. S. Lourenço
.
Journal of Microwaves, Optoelectronics and Electromagnetic Applications
- Métricas do periódico
Abstract This paper presents an eyebolt structural fault detection system, based on the analysis of multiple electromagnetic parameters through a random forest classifier trained by both measurements and high-fidelity simulated signals. The proposed methodology is completely noninvasive and does not require the disassembly of the electrical infrastructure, allowing the live-line working. The obtained results show that the proposed multi-parameter strategy achieves high accuracy and increases the system’s capability of detecting faults, improving the efficiency of the operator’s preventive maintenance routines and, consequently, increasing the reliability of the power supply and energy distribution systems. system highfidelity fidelity signals infrastructure liveline live line working multiparameter multi parameter systems s faults operators operator consequently
6.
EXEMPLIFICANDO O USO DO MACRO MAPEAMENTO ELEMENTAR POR XRF (MA-XRF) NA INVESTIGAÇÃO FORENSE DE OBRAS DE ARTE
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Pimenta, André R.
; Felix, Valter S.
; Silva, Daniele M.
; Pereira, Marcelo O.
; Oliveira, Ana L.
; Ferreira, Douglas S.
; Carvalho, Cristiano S.
; Silva, Fabricio L.
; Gonçalves, Elicardo A.S.
; Dutra, Rafael S.
; Pereira, Leandro O.
; Pereira, Ronaldo V.
; Freitas, Renato P.
.
EXEMPLIFYING THE USE OF MACRO ELEMENTAL MAPPING BY XRF (MA-XRF) SCANNING IN FORENSIC INVESTIGATION OF ARTWORKS. This work exemplifies the potential of employing macro elemental mapping by XRF (MA XRF) scanning in the forensic investigation of artworks. The results of the investigation of two artworks of different styles and periods are presented and discussed. The images provided by MA-XRF scanning have information about the elemental distribution, which is related to pigments used in the artwork. These images bring different information such as: if there are underlying paintings; if a given pigment was used for the purpose of restoration or in the creation. Therefore, through the images, it is possible to obtain information, which refers to the process of creating the artwork and the history of conservation and restoration. Through the results, it was possible to verify that the two artworks are probably false because they present anachronistic pigments with the supposed period of creation. The analyzes were performed using a portable MA-XRF scanning system, and in addition to presenting the utility of the instrument in these investigations, the work also presents possibilities to explore the MA-XRF data through multivariate statistical analysis and image correlation.
7.
Organic fertilization in the production and chemical composition of non-conventional leafy vegetables
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Batista, Deborah Sepini
; Mantovani, José Ricardo
; Silva, Luis Felipe Lima e
; Souza, Douglas Correa de
; Landgraf, Paulo Roberto Corrêa
.
RESUMO As hortaliças folhosas não convencionais podem ser uma boa fonte de nutrientes para a dieta humana, mas há poucas informações sobre adubação para essas espécies. Objetivou-se avaliar o efeito da adubação orgânica com esterco bovino na produção e composição química de hortaliças folhosas não convencionais. O experimento foi conduzido em casa-de-vegetação, em vasos. Os fatores em estudo foram espécies de hortaliças não convencionais (Rumex acetosa, Stachys byzantina e Lactuca canadensis) e doses de esterco bovino (0; 5; 10; 15; e 20 t ha-1), arranjados em esquema fatorial 3 x 5, em delineamento de blocos ao acaso, com quatro repetições. Na colheita, foram avaliados o diâmetro de caule, número total de folhas, número de folhas com padrão comercial, matéria fresca e seca da parte aérea, concentração e quantidades acumuladas de macro e micronutrientes na parte aérea. A adubação com esterco bovino alterou o diâmetro de caule, número de folhas com padrão comercial, matéria fresca e seca da parte aérea, bem como o acúmulo dos nutrientes N, P, K, Ca, Fe, Mn e Zn na parte aérea das três espécies estudadas. Os acréscimos obtidos variaram de 1,1 a 2,1 vezes, em relação ao tratamento sem adubação orgânica, e a dose equivalente a 20 t ha-1 foi a mais adequada. A adubação orgânica com esterco bovino aumenta a produção e o acúmulo de nutrientes nas hortaliças não convencionais avaliadas, sendo que R. acetosa apresenta maior acúmulo de nutrientes do que S. byzantina e L. canadensis.
ABSTRACT Non-conventional leafy vegetables can be a good source of nutrients for the human diet, but there is little information on fertilization for these species. This study aimed to evaluate the effect of organic fertilization with cattle manure on the production and chemical composition of non-conventional leafy vegetables. The experiment was conducted in a greenhouse, in pots. The factors under study were non-conventional leafy species (Rumex acetosa, Stachys byzantina and Lactuca canadensis) and cattle manure doses (0; 5; 10; 15; and 20 t ha-1), arranged in a 3 x 5 factorial scheme, in a randomized block design, with four replications. At harvest, the following parameters were evaluated: stem diameter; total number of leaves; number of leaves with commercial standard; shoot fresh and dry matter; macro and micronutrients concentration and accumulated amounts in the shoot. The fertilization with cattle manure altered the stem diameter, number of leaves with commercial standard, shoot fresh and dry matter, as well as the accumulation of the nutrients N, P, K, Ca, Fe, Mn and Zn in the shoot of the three species studied. The additions obtained varied from 1.1 to 2.1 times, in relation to the treatment without organic fertilization, and the dose equivalent to 20 t ha-1 was the most adequate one. The organic fertilization with cattle manure increases the production and accumulation of nutrients in the non-conventional vegetables evaluated, with R. acetosa presenting a nutrient accumulation higher than S. byzantina and L. canadensis.
https://doi.org/10.1590/1983-40632021v5166508
178 downloads
8.
Quantification of Glyphosate and AMPA by HPLC-ICP-MS/MS and HPLC-DAD: A Comparative Study
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Pimenta, Emanuella M.
; Silva, Fabio F. da
; Barbosa, Érica S.
; Cacique, Ane P.
; Cassimiro, Douglas L.
; Pinho, Gevany P. de
; Silvério, Flaviano O.
.
Journal of the Brazilian Chemical Society
- Métricas do periódico
In this work, the direct determination methodology of glyphosate and aminomethylphosphonic acid (AMPA) by high performance liquid chromatography (HPLC) using inductively coupled plasma with triple quadrupole mass spectrometer (ICP-MS/MS) was compared with the conventional method using diode array detector (HPLC-DAD). Both methods were selective, but the chromatographic analysis using ICP-MS/MS as detector was four times faster than DAD. The methodology using ICP-MS/MS as detector was linear from 27 to 218 µg L-1, while by the conventional method it was 1 to 8 mg L-1. Detection limits of the glyphosate achieved with the HPLC-ICP-MS/MS and HPLC-DAD methods were 8.2 and 300 µg L-1, respectively. The direct determination using ICP-MS/MS as detector showed a lower number of stages in sample preparation because it did not need the derivatization step. Seven real samples were analyzed by HPLC-ICP-MS/MS and the results showed that these analytes were not detected.
https://doi.org/10.21577/0103-5053.20190175
1148 downloads
9.
Disseminated and cutaneous cryptococcosis by C. neoformans VNI in an immunocompetent patient
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Maranhão, Fernanda Cristina A
; Fonseca, Douglas L. H
; Santos, Graciella S. A
; Fonseca, Luisa Andrea V
; Santos, Eduardo José L
; Silva, Denise Maria W
.
Jornal Brasileiro de Patologia e Medicina Laboratorial
- Métricas do periódico
RESUMO A criptococose é causada por leveduras do complexo Cryptococcus neoformans/C. gattii e se apresenta nas formas cutânea, respiratória e disseminada. Um homem imunocompetente de 44 anos com lesão facial e pneumonia latente foi hospitalizado e erroneamente diagnosticado com paracoccidioidomicose. Tomografias computadorizadas mostraram envolvimento pulmonar e neurológico, e culturas/tinta da China, teste do antígeno criptocócico e técnica de polimorfismo de comprimento de fragmentos de restrição dogene urease (URA5-RFLP) confirmaram C. neoformans genótipo VNI. Hemocultura indicou Klebsiella pneumoniae resistente à ampicilina (infecção relacionada com a assistência à saúde). Fluconazol foi administrado, mas após detecção de resistência, optou-se por anfotericina B (dose cumulativa/1500 mg). O paciente recebeu alta com remissão clínica (75 dias) e administração de anfotericina B por um ano (fase de manutenção).
ABSTRACT Cryptococcosis is caused by yeasts of the Cryptococcus neoformans/C. gattii complex, presenting cutaneous, respiratory and disseminated forms. A 44-year-old immunocompetent male with facial lesion and latent pneumonia was hospitalized and misdiagnosed with paracoccidioidomycosis. Computerized tomography scans showed pulmonary and neurological involvement, and cultures/China ink, cryptococcal antigen test and restriction fragment length polymorphism of urease gene (URA5-RFLP) confirmed C. neoformans genotype VNI. Hemoculture indicated ampicillin-resistant Klebsiella pneumoniae (healthcare-associated infection). Fluconazole was administered, but after resistance detection, amphotericin B was chosen (cumulative dose/1500 mg). The patient was discharged with clinical remission (75 days) and amphotericin for one year (maintenance phase).
RESUMEN La criptococosis es causada por levaduras del complejo Cryptococcus neoformans/C. gattii y se presenta en las formas cutánea, respiratoria y diseminada. Un hombre inmunocompetente de 44 años de edad con lesión facial y neumonía latente fue hospitalizado y erróneamente diagnosticado con paracoccidioidomicosis. Tomografías computarizadas mostraron afectación pulmonar y neurológica, y culturas/tinta china, prueba del antígeno criptocócico y URA5-polimorfismos en la longitud de los fragmentos de restricción (RFLP) confirmaron C. neoformans genotipo VNI. El hemocultivo indicó Klebsiella pneumoniae resistente a la ampicilina (infección asociada a la atención en salud). El fluconazol le fue administrado, pero tras detección de resistencia, se optó por anfotericina B (dosis acumulativa/1500 mg). Al paciente le dieron el alta en remisión clínica (75 días) y administración de anfotericina B durante un año (fase de mantenimiento).
https://doi.org/10.5935/1676-2444.20200017
1783 downloads
10.
Silicate fertilization in non-conventional vegetables in the southern region of Minas Gerais in Brazil
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Oliveira, Luis Cláudio Pessoa
; Souza, Douglas Correa de
; Silva, Luis Felipe Lima e
; Resende, Luciane Vilela
; Silva, Maria Ligia de Souza
; Guerra, Thiago Sampaio
.
ABSTRACT Considering that the beneficial effects of silicon on human health and it´s accumulation in plants are little explored, studies of mineral nutrition in non-conventional vegetables are extremely relevant. Thus, the objective of this work was to identify non-conventional vegetables responsive to silica fertilization and evaluate the effect of fertilization on the content and accumulation of Si and macronutrients in these plants. The experiment followed a 4 x 5 factorial design, with four species of non-conventional vegetables (Rumex acetosa L., Amaranthus retroflexus L., Sonchus oleraceus L. and Stachys byzantina) and five doses of Si (0, 25, 50, 100 and 150 mg dm-3). The relative chlorophyll index, the fresh and dry matter masses, the content and accumulation of Si and macronutrients were evaluated. The species A. retroflexus, S. oleraceus. and S. byzantina showed the highest contents and accumulation of Si. The application of doses above 100 mg dm-3 promoted the highest silicon content estimated for the species. The species A. retroflexus, R. acetosa and S. byzantina are non-silicon accumulators, whereas S. oleraceus is intermediate.
https://doi.org/10.1590/0034-737x201966060008
948 downloads
11.
A NOVEL Scytalidium SPECIES: UNDERSTAND THE CELLULOLYTIC SYSTEM FOR BIOMASS SACCHARIFICATION
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Delabona, Priscila da S.
; Silva, Mateus R.
; Paixão, Douglas A. A.
; Lima, Deise J.
; Rodrigues, Gisele N.
; Lee, Marcela do S.
; Souza, Márcia G. da S.
; Bussamra, Bianca C.
; Santos, Alberdan S.
; Pradella, José G. da C.
.
Brazilian Journal of Chemical Engineering
- Métricas do periódico
ABSTRACT In order to overcome the bottlenecks related to lignocellulosic-derived sugars, the search for more efficient enzymatic cocktails, containing a broad-spectrum of specific activities, relies on an important feature. This paper describes new enzyme activities derived from the novel strain of the Scytalidium genus isolated from the Amazonas rainforest. The production of the enzymatic cocktail was induced by delignified-hydrothermal bagasse (DHB), and yeast extract was used to improve secretion activities, resulting in a positive influence on total cellulase activity. The enzymatic cocktail produced by this novel strain contains specific activities for biomass degradation, including FPAse, xylanase and β-glucosidase. Moreover, it is capable of hydrolyzing 62% of the alkaline pretreated bagasse, surpassing in 14% the hydrolytic capability achieved by the commercial cocktail Celluclast. To this extent, the strain described here emerges as a reliable alternative to other available enzymes and, consequently, amplification of available specific substrate activities.
https://doi.org/10.1590/0104-6632.20190361s20170495
603 downloads
12.
Materials from renewable resources: new properties and functions
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Anais da Academia Brasileira de Ciências
- Métricas do periódico
Abstract: Sustainable production requires increasing use of raw materials from renewable sources, processed under mild conditions with minimal effluent production. These requirements are satisfied by using materials derived from biomass, in synergy with food and energy production. The possibilities of biomass are continuously enlarged by new findings, as in the intrinsic nanocomposite properties of natural rubber and the amphiphile behavior of cellulose that translated into new functional materials, including high-performance, flexible and conductive non-metallic materials. Other findings are allowing a better understanding of electrostatic phenomena that play a positive role in electrostatic adhesion and cohesion of nanocomposites made from biomass products. Moreover, this should allow the development of safe electrostatic separation techniques, suitable for the fractionation of crude mixtures of biomass residues. A current study on rubber electrostatics is showing its capabilities as a transducer of mechanical energy while providing clues to understand the performance of the dielectric elastomers used in robotic self-sensing actuators.
https://doi.org/10.1590/0001-3765201920181160
2058 downloads
13.
Drying kinetics of baru flours as function of temperature
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Reis, Douglas R.
; Brum, Fabrício B.
; Soares, Eduardo J. O.
; Magalhães, Jessiana R.
; Silva, Fabrício S.
; Porto, Alexandre G.
.
Revista Brasileira de Engenharia Agrícola e Ambiental
- Métricas do periódico
RESUMO Vários tipos de sementes têm sido introduzidos em formulações na indústria de alimentos, graças ao grande potencial que as proteínas vegetais apresentam. O baru, fruto disseminado no bioma cerrado, apresenta em sua castanha um alto valor nutricional. O presente trabalho teve como objetivo determinar e analisar a cinética de secagem da farinha integral e desengordurada da amêndoa do baru em diferentes temperaturas. A farinha resultante da moagem das amêndoas foi desengordurada por éter de petróleo. As secagens foram realizadas nas temperaturas de 40, 50 e 60 °C. Os dados experimentais foram ajustados aos modelos matemáticos de Page, Henderson e Pabis, Midilli & Kucuk, Thompson e Aproximação da Difusão. Os resultados demonstraram notável efeito da temperatura do ar na cinética de secagem da farinha integral e desengordurada da amêndoa do baru. A farinha da amêndoa integral apresentou perdas de umidade mais lentas do que a farinha desengordurada. Segundo os parâmetros estatísticos de análises, os modelos de Midilli & Kucuk e Page foram os que obtiveram os melhores ajustes dos dados experimentais. Os valores de difusividade efetiva encontrados variaram de 8,02 × 10–10 a 19,90 × 10–10 m2 s-1 e para a energia de ativação foram de 22,39 e 39,37 KJ mol-1 para a amêndoa integral e desengordurada, respectivamente.
ABSTRACT Several types of seeds have been initially used in the food industry due to the great potential that vegetable proteins have. Baru is a fruit commonly found in the Cerrado biome, having a high nutritional value. This paper aimed to determine and analyze the drying kinetics of whole and defatted baru almond flours at different temperatures. The flour resulting from almond milling was defatted using petroleum ether. The drying processes were performed at temperatures of 40, 50 and 60 ºC. The mathematical models of Page, Henderson and Pabis, Midilli & Kucuk, Thompson and Approximation of Diffusion were fitted to the experimental data. The results showed a noticeable effect of air temperature on the drying kinetics of whole and defatted baru almond flours. According to the statistical parameters of analysis, the models Midilli & Kucuk and Page were the ones with the best fits to the experimental data. The effective diffusivity values found ranged from 8.02 × 10–10 to 19.90 × 10–10 m2 s-1 and for the activation energy were 22.39 and 39.37 KJ mol-1 for whole and defatted almonds, respectively.
https://doi.org/10.1590/1807-1929/agriambi.v22n10p713-719
1008 downloads
14.
Influence of irrigation, planting density and vegetative propagation on yield of rhizomes of starch the arrowroot
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Souza, Douglas C. de
; Silva, Luis F. L.
; Resende, Luciane V.
; Costa, Paula A.
; Guerra, Thiago S.
; Gonçalves, Wilson M.
.
A araruta é considerada uma hortaliça não convencional que vem despertando interesse da indústria alimentícia em virtude de seu amido, com características diferenciadas e elevado valor comercial. Contudo, são escassas as informações quanto ao manejo, dificultando sua competição comercial com outras espécies de finalidade semelhante, sendo necessários mais estudos com a cultura. Diante disso, objetivou-se definir práticas adequadas de manejo da cultura visando produtividade de rizomas, rendimento de fécula e amido de araruta. Os fatores avaliados foram diferentes níveis de manejo de água, sistema de plantio e de densidades de plantas. O delineamento experimental foi de blocos casualizados no ensaio de campo e inteiramente casualizados para as análises laboratoriais. Mediante os tratamentos, a produtividade da cultura variou de 0,68 (mudas; sem irrigação; 31250 plantas ha-1) a 60,09 t ha-1(mudas; irrigado; 31250 plantas ha-1), enquanto que a produção de amido foi de 50 a 6.350 kg ha-1. A maior produtividade de rizomas foi obtida em plantas produzidas por mudas juntamente com a maior densidade de plantas, e a maior produção de fécula e amido de araruta foi extraída de rizomas oriundos de plantas produzidas por mudas, sem uso de irrigação e densidade de 50.000 plantas ha-1.
The arrowroot is considered a non-conventional vegetable which has aroused interest in the food industry because of its starch content with differentiated characteristics and high commercial value. However, agronomic management information is scarce, making it difficult to compete with other species of similar purpose, and more studies are needed regarding the crop. The aim of this study was to define adequate agronomic practices in crop aiming the productivity the rhizome, yield the starch of arrowroot. The factors evaluated were the different levels of irrigation, the planting and the plant densities. The randomized block design was used in the field trial while the totally randomized block design was used in the laboratory tests. Through the treatments, crop yield ranged from 0.68 (seedlings; without irrigation; 31250 plants ha-1) to 60.09 t ha-1 (seedlings; irrigated; 31250 plants ha-1), while starch production ranged from 50 to 6350 kg ha-1. The highest yield of rhizomes was obtained in plants produced by seedlings along with the highest density of plants, and the highest production of arrowroot starch was extracted from rhizomes from plants produced by seedlings without irrigation and a density of 50000 plants ha-1.
https://doi.org/10.19084/RCA18015
670 downloads
15.
Extended-time of Noninvasive Positive Pressure Ventilation Improves Tissue Perfusion after Coronary Artery Bypass Surgery: a Randomized Clinical Trial
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Nasrala, Mara L. S.
; Bolzan, Douglas W.
; Lage, Yumi G.
; Prado, Fabiana S.
; Arena, Ross
; Lima, Paulo R. L.
; Feguri, Gibran
; Silva, Ageo M. C.
; Marcondi, Natasha O.
; Hossne, Nelson
; Guizilini, Solange
; Gomes, Walter J.
.
Brazilian Journal of Cardiovascular Surgery
- Métricas do periódico
Abstract Objective: To compare the effects of extended- versus short-time noninvasive positive pressure ventilation on pulmonary function, tissue perfusion, and clinical outcomes in the early postoperative period following coronary artery bypass surgery in patients with preserved left ventricular function. Methods: Patients were randomized into two groups according to noninvasive positive pressure ventilation intensity: short-time noninvasive positive pressure ventilation n=20 (S-NPPV) and extended-time noninvasive positive pressure ventilation n=21 (E-NPPV). S-NPPV was applied for 60 minutes during immediate postoperative period and 10 minutes, twice daily, from postoperative days 1-5. E-NPPV was performed for at least six hours during immediate postoperative period and 60 minutes, twice daily, from postoperative days 1-5. As a primary outcome, tissue perfusion was determined by central venous oxygen saturation and blood lactate level measured after anesthetic induction, immediately after extubation and following noninvasive positive pressure ventilation protocols. As a secondary outcome, pulmonary function tests were performed preoperatively and in the postoperative days 1, 3, and 5; clinical outcomes were recorded. Results: Significant drop in blood lactate levels and an improvement in central venous oxygen saturation values in the E-NPPV group were observed when compared with S-NPPV group after study protocol (P<0.01). The E-NPPV group presented higher preservation of postoperative pulmonary function as well as lower incidence of respiratory events and shorter postoperative hospital stay (P<0.05). Conclusion: Prophylactic E-NPPV administered in the early postoperative period of coronary artery bypass surgery resulted in greater improvements in tissue perfusion, pulmonary function and clinical outcomes than S-NPPV, in patients with preserved left ventricular function. Trial Registration: Brazilian Registry of Clinical trial - RBR7sqj78 - http://www.ensaiosclinicos.gov.br
https://doi.org/10.21470/1678-9741-2017-0232
886 downloads
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---|---|
ti | título do artigo |
au | autor |
kw | palavras-chave do artigo |
subject | assunto (palavras do título, resumo e palavras-chave) |
ab | resumo |
ta | título abreviado da revista (ex. Cad. Saúde Pública) |
journal_title | título completo da revista (ex. Cadernos de Saúde Pública) |
la | código do idioma da publicação (ex. pt - Português, es - Espanhol) |
type | tipo do documento |
pid | identificador da publicação |
publication_year | ano de publicação do artigo |
sponsor | financiador |
aff_country | código do país de afiliação do autor |
aff_institution | instituição de afiliação do autor |
volume | volume do artigo |
issue | número do artigo |
elocation | elocation |
doi | número DOI |
issn | ISSN da revista |
in | código da coleção SciELO (ex. scl - Brasil, col - Colômbia) |
use_license | código da licença de uso do artigo |