The use of materials such as organofunctionalized silica for application in solid phase extraction (SPE) allows the preconcentration of several ions, including Pt, and subsequent detection. This work aims to synthesize and characterize an organofunctionalized silica (Sil-TMSDT) with the silylant N’(trimethoxysilyl)propylethylenetriamine and its application as a solid phase in the preconcentration Pt4+ ions in aqueous media, using detection by flame atomization atomic absorption spectroscopy (FAAS). The Fourier-transform infrared spectroscopy (FTIR) spectra and scanning electron microscopy (SEM) coupled with energy-dispersive spectroscopy (EDS) confirmed the aminofunctionalization of the silica. For the adsorption process, a preconcentration mini-column with 200 mg of Sil-TMSDT, a solution of 0.485 mg L−1 of K2[PtCl6] at pH 10 and HNO3 0.5 mol L−1 as eluent were used, obtaining an enrichment factor of 15-fold with retention efficiency higher than 99%. The Pt4+ ion determined by FAAS showed a linear response between 0.02 and 0.40 mg L−1; a linear coefficient where R = 0.9981; a 16-fold preconcentration factor; a limit of quantification (LOQ) and limit of detection (LOD) of 0.045 and 0.014 mg L−1, respectively. The proposal system showed analytical applicability to determining Pt4+ ion in an aqueous medium and could be used to detect traces of this potentially toxic metal in biological fluids such as urine and blood. SPE (SPE Pt SilTMSDT Sil TMSDT (Sil-TMSDT Ntrimethoxysilylpropylethylenetriamine N trimethoxysilyl propylethylenetriamine Pt4 media FAAS. . (FAAS) Fouriertransform Fourier transform FTIR (FTIR SEM (SEM energydispersive energy dispersive EDS (EDS process minicolumn mini column 20 SilTMSDT, TMSDT, Sil-TMSDT 0485 0 485 0.48 L1 L 1 L− K2PtCl6 KPtCl K2 PtCl6 K PtCl K2[PtCl6 HNO 05 5 0. 15fold fold 15 99 99% 002 02 0.0 040 40 0.4 0.9981 09981 9981 16fold 16 LOQ (LOQ LOD (LOD 0045 045 0.04 0014 014 0.01 respectively blood (FAAS 2 048 48 K2PtCl K2[PtCl 9 00 04 4 0.998 0998 998 004 001 01 0.99 099 0.9 09

ABSTRACT Peanut (Arachis hypogaea) is an important agricultural crop in Brazil, considered one of the most important oilseed crops cultivated. The use of fertilizer-solubilizing bacteria can mitigate salt stress. The objective of this study was to evaluate the gas exchange, growth, and water use efficiency of the peanut crop irrigated with brackish water under phosphate fertilization and inoculated with bacteria of the genus Bacillus sp. The experimental design used in this study was completely randomized, in a 4 × 2 × 2 factorial scheme, with 5 replicates, referring to the forms of fertilization (F1 - 0% phosphorus, F2 - 50% phosphorus, F3 - 100% phosphorus, and F4 - bovine biofertilizer), presence and absence of the inoculant and two levels of electrical conductivity of the irrigation water (ECw - 0.3 and 4.0 dS m-1). Fertilization with organic fertilizer (100% biofertilizer) and mineral fertilizer (50 and 100% phosphorus) associated with Bacillus sp. mitigated the damage caused by salt stress and promoted greater water use efficiency, chlorophyll index, internal CO2 concentration and stem diameter. The control treatment (without phosphate fertilization and without salt stress) and the application of Bacillus sp. promoted greater performance in net photosynthesis, transpiration rate, stomatal conductance, and plant height in peanut plants. Arachis hypogaea Brazil cultivated fertilizersolubilizing solubilizing exchange growth sp randomized scheme replicates F1 F (F 0 phosphorus 50 100 biofertilizer, biofertilizer , ECw 03 3 0. 40 4. m1. m1 m 1 . m-1) (100 (5 index CO diameter photosynthesis rate conductance plants 10 m-1 (10 ( m- (1

RESUMO O amendoim (Arachis hypogaea) é uma importante cultura agrícola no Brasil, considerada uma das mais importantes oleaginosas cultivadas. O uso de bactérias solubilizadoras de fertilizantes pode mitigar o estresse salino. O objetivo deste estudo foi avaliar as trocas gasosas, o crescimento e a eficiência do uso da água da cultura do amendoim irrigado com água salobra sob adubação fosfatada e inoculada com bactérias do gênero Bacillus sp. O delineamento experimental utilizado neste estudo foi inteiramente casualizado, em esquema fatorial 4 × 2 × 2, com 5 repetições, referente às formas de adubação (F1 - 0% fósforo, F2 - 50% fósforo, F3 - 100% fósforo e F4 - bovino biofertilizante), presença e ausência do inoculante e dois níveis de condutividade elétrica da água de irrigação (CEa - 0.3 e 4.0 dS m-1). As adubações com fertilizante orgânico (100% de biofertilizante) e mineral (50 e 100% de fósforo) associada a Bacillus sp. mitigou os danos causados pelo estresse salino e proporcionou maior eficiência no uso da água, índice de clorofila, concentração interna de CO2 e diâmetro do caule. O tratamento controle (sem adubação fosfatada e sem estresse salino) e a aplicação de Bacillus sp., promoveu maior desempenho na fotossíntese líquida, taxa de transpiração, condutância estomática e altura das plantas em plantas de amendoim. Arachis hypogaea Brasil cultivadas gasosas sp casualizado repetições F1 F (F 0 50 100 biofertilizante, biofertilizante , CEa 03 3 0. 40 4. m1. m1 m 1 . m-1) (100 (5 clorofila CO caule líquida transpiração 10 m-1 (10 ( m- (1

ABSTRACT Salt stress hampers the growth and physiology of nasturtium (Tropaeolum majus), due to biochemical, physiological, and anatomical disruptions. The application of salicylic acid stands as an alternative to alleviate the detrimental effects of salt stress, but studies on nasturtium are scarce. Thus, the aim of present study was to assess the effects of foliar application of salicylic acid on nasturtium cultivated under salt stress. The experiment followed a completely randomized design in a 3 x 3 factorial scheme, with 0 (no stress), 50 (moderate salt stress), and 100 (severe salt stress) mM of NaCl, and application of 0, 0.5, and 1 mM of salicylic acid, each with six replications. Growth (plant height, stem diameter, and number of leaves), gas exchange (stomatal conductance, photosynthesis, transpiration, internal CO2 concentration, intrinsic water use efficiency, instantaneous water use efficiency, and intrinsic carboxylation efficiency), as well as chlorophyll indices and chlorophyll a fluorescence were evaluated. Salt stress affected the variables analyzed in this study. The application of salicylic acid had a positive effect on mitigating the effects of severe salt stress, resulting in a significant increase in the number of leaves. The most effective dose was 1 mM, also leading to notable improvements in water use efficiency and photochemical efficiency. However, other combinations of salinity and salicylic acid reduced growth and gas exchange in nasturtium plants. Tropaeolum majus, majus , majus) biochemical physiological disruptions scarce Thus scheme no 5 moderate 10 NaCl 05 0.5 replications plant height diameter leaves, leaves leaves) stomatal conductance photosynthesis transpiration CO concentration efficiency) evaluated However plants 0.

RESUMO O estresse salino limita o crescimento e a fisiologia da capuchinha (Tropaeolum majus), devido a distúrbios bioquímicos, fisiológicos e anatômicos. A aplicação de ácido salicílico é uma alternativa para mitigar os efeitos prejudiciais do estresse salino, no entanto, em capuchinha os estudos são escassos. Assim, objetivou-se avaliar os efeitos da aplicação de ácido salicílico via foliar em capuchinha cultivada sob estresse salino. O experimento foi realizado em delineamento inteiramente casualizado, em esquema fatorial 3 x 3, referente a 0 (sem estresse) 50 (estresse salino moderado) e 100 (estresse salino severo) mM de NaCl e aplicação de 0, 0,5 e 1 mM de ácido salicílico, com seis repetições. O crescimento (altura de planta, diâmetro do caule e número de folhas), trocas gasosas (condutância estomática, fotossíntese, transpiração, concentração interna de CO2, eficiência intrínseca do uso da água, eficiência instantânea do uso da água e eficiência intrínseca de carboxilação) e os índices de clorofila e fluorescência da clorofila a foram avaliados. O estresse salino afetou as variáveis analisadas neste estudo. A aplicação de ácido salicílico teve um efeito positivo na mitigação dos efeitos do estresse salino severo, resultando em um aumento significativo no número de folhas, sendo a dose mais eficaz a concentração de 1 mM, levando ainda, a melhorias notáveis na eficiência no uso da água e na eficiência fotoquímica. No entanto, as demais combinações de salinidade e ácido salicílico reduziram o crescimento e as trocas gasosas nas plantas de capuchinha. Tropaeolum majus, majus , majus) bioquímicos anatômicos entanto escassos Assim objetivouse objetivou se casualizado sem 5 moderado 10 severo 05 repetições altura planta folhas folhas) condutância estomática fotossíntese transpiração CO2 CO carboxilação avaliados estudo ainda fotoquímica

Abstract This study is the first to apply training impulse (TRIMP) and Training Monotony (TM) methodologies, within the realm of sport science, in animal model studies. Rats were divided into Sedentary (SED, n=10) and Training (TR, n=13). TR performed a four-week moderate-intensity interval training with load progression. Lactate kinetics, lactate training impulse (TRIMPLac), maximal speed training impulse (TRIMPSmax) and TM were utilized to develop and monitor training protocol. TR showed an 11.9% increase in time to exhaustion at the second maximum incremental test and a 17.5% increase at the third test. External work was increased by 17.8% at the second test and 30.3% at the third. There was a 10.6% increase in external work at the third test compared to the second for TR. No difference in TRIMPLac between the 1st week (94±9 A.U) and 3rdweek (83±10 A.U) were seen. TRIMPSmax was 2400 A.U. in the 1st week, 2760 A.U. in the 2nd and 3rd weeks, and 3120 A.U. in the 4th week. The TM remained at 1.24 A.U throughout the protocol and there was no dropouts. TRIMPLac and TRIMPSmax contributed to the development and monitoring loads, demonstrating their potential to improve the accuracy of training protocols in animal model research. TRIMP (TRIMP (TM methodologies science studies SED, SED (SED n=10 n10 n 10 TR, (TR n=13. n13 n=13 . 13 n=13) fourweek four moderateintensity moderate intensity progression kinetics TRIMPLac, , (TRIMPLac) (TRIMPSmax 119 11 9 11.9 175 17 5 17.5 178 8 17.8 303 30 3 30.3 106 6 10.6 st 94±9 949 94 (94± AU A U rdweek 83±10 8310 83 (83±1 seen 240 276 nd rd weeks 312 th 124 1 24 1.2 dropouts loads research n=1 n1 (TRIMPLac 11. 17. 30. 10. 94± (94 83±1 831 (83± 27 31 12 2 1. n= (9 83± (83 ( (8

Abstract Background: Tele-cardiology tools are valuable strategies to improve risk stratification. Objective: We aimed to evaluate the accuracy of tele-electrocardiography (ECG) to predict abnormalities in screening echocardiography (echo) in primary care (PC). Methods: In 17 months, 6 health providers at 16 PC units were trained on simplified handheld echo protocols. Tele-ECGs were recorded for final diagnosis by a cardiologist. Consented patients with major ECG abnormalities by the Minnesota code, and a 1:5 sample of normal individuals underwent clinical questionnaire and screening echo interpreted remotely. Major heart disease was defined as moderate/severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion, or wall-motion abnormalities. Association between major ECG and echo abnormalities was assessed by logistic regression as follows: 1) unadjusted model; 2) model 1 adjusted for age/sex; 3) model 2 plus risk factors (hypertension/diabetes); 4) model 3 plus history of cardiovascular disease (Chagas/rheumatic heart disease/ischemic heart disease/stroke/heart failure). P-values < 0.05 were considered significant. Results: A total 1,411 patients underwent echo; 1,149 (81%) had major ECG abnormalities. Median age was 67 (IQR 60 to 74) years, and 51.4% were male. Major ECG abnormalities were associated with a 2.4-fold chance of major heart disease on echo in bivariate analysis (OR = 2.42 [95% CI 1.76 to 3.39]), and remained significant after adjustments in models (p < 0.001) 2 (OR = 2.57 [95% CI 1.84 to 3.65]), model 3 (OR = 2.52 [95% CI 1.80 to3.58]), and model 4 (OR = 2.23 [95%CI 1.59 to 3.19]). Age, male sex, heart failure, and ischemic heart disease were also independent predictors of major heart disease on echo. Conclusions: Tele-ECG abnormalities increased the likelihood of major heart disease on screening echo, even after adjustments for demographic and clinical variables. Background Telecardiology Tele cardiology stratification Objective teleelectrocardiography tele electrocardiography (ECG (echo PC. . (PC) Methods months protocols TeleECGs ECGs cardiologist code 15 5 1: remotely moderatesevere moderate severe dysfunctionhypertrophy dysfunction hypertrophy dysfunction/hypertrophy effusion wallmotion wall motion follows age/sex agesex sex hypertension/diabetes hypertensiondiabetes hypertension diabetes (hypertension/diabetes) Chagas/rheumatic Chagasrheumatic Chagas rheumatic diseaseischemic diseasestrokeheart stroke failure. failure failure) Pvalues P values 005 0 05 0.0 Results 1411 411 1,41 1149 149 1,14 81% 81 (81% IQR 74 years 514 51 51.4 2.4fold 24fold fold 2.4 OR 242 42 95% 95 [95 176 76 1.7 3.39, 339 3.39 , 39 3.39]) p 0.001 0001 001 257 57 2.5 184 84 1.8 3.65, 365 3.65 65 3.65]) 252 52 180 80 to3.58, to358 to3.58 to3 58 to3.58]) 223 23 2.2 95%CI 95CI 159 59 1.5 3.19. 319 3.19 19 3.19]) Age Conclusions TeleECG variables (PC (hypertension/diabetes 00 0. 141 41 1,4 114 14 1,1 8 (81 7 51. 4fold 24 2. 9 [9 1. 33 3.3 3.39] 0.00 000 25 18 36 3.6 3.65] to35 to3.5 to3.58] 22 31 3.1 3.19] 1, 11 (8 [ 3. to3. (

Resumo Fundamento: As ferramentas de telecardiologia são estratégias valiosas para melhorar a estratificação de risco. Objetivo: Objetivamos avaliar a acurácia da tele-eletrocardiografia (ECG) para predizer anormalidades no ecocardiograma de rastreamento na atenção primária. Métodos: Em 17 meses, 6 profissionais de saúde em 16 unidades de atenção primária foram treinados em protocolos simplificados de ecocardiografia portátil. Tele-ECGs foram registrados para diagnóstico final por um cardiologista. Pacientes consentidos com anormalidades maiores no ECG pelo código de Minnesota e uma amostra 1:5 de indivíduos normais foram submetidos a um questionário clínico e ecocardiograma de rastreamento interpretado remotamente. A doença cardíaca grave foi definida como doença valvular moderada/grave, disfunção/hipertrofia ventricular, derrame pericárdico ou anormalidade da motilidade. A associação entre alterações maiores do ECG e anormalidades ecocardiográficas foi avaliada por regressão logística da seguinte forma: 1) modelo não ajustado; 2) modelo 1 ajustado por idade/sexo; 3) modelo 2 mais fatores de risco (hipertensão/diabetes); 4) modelo 3 mais história de doença cardiovascular (Chagas/cardiopatia reumática/cardiopatia isquêmica/AVC/insuficiência cardíaca). Foram considerados significativos valores de p < 0,05. Resultados: No total, 1.411 pacientes realizaram ecocardiograma, sendo 1.149 (81%) com anormalidades maiores no ECG. A idade mediana foi de 67 anos (intervalo interquartil de 60 a 74) e 51,4% eram do sexo masculino. As anormalidades maiores no ECG se associaram a uma chance 2,4 vezes maior de doença cardíaca grave no ecocardiograma de rastreamento na análise bivariada (OR = 2,42 [IC 95% 1,76 a 3,39]) e permaneceram significativas (p < 0,001) após ajustes no modelo 2 (OR = 2,57 [IC 95% 1,84 a 3,65]), modelo 3 (OR = 2,52 [IC 95% 1,80 a 3,58]) e modelo 4 (OR = 2,23 [IC 95% 1,59 a 3,19]). Idade, sexo masculino, insuficiência cardíaca e doença cardíaca isquêmica também foram preditores independentes de doença cardíaca grave no ecocardiograma. Conclusões: As anormalidades do tele-ECG aumentaram a probabilidade de doença cardíaca grave no ecocardiograma de rastreamento, mesmo após ajustes para variáveis demográficas e clínicas. Fundamento Objetivo teleeletrocardiografia tele eletrocardiografia (ECG Métodos meses portátil TeleECGs Tele ECGs cardiologista 15 5 1: remotamente moderadagrave moderada moderada/grave disfunçãohipertrofia disfunção hipertrofia ventricular motilidade forma idade/sexo idadesexo hipertensão/diabetes hipertensãodiabetes hipertensão diabetes (hipertensão/diabetes) Chagas/cardiopatia Chagascardiopatia Chagas cardiopatia reumáticacardiopatia reumática isquêmicaAVCinsuficiência AVC cardíaca. . cardíaca) 005 0 05 0,05 Resultados total 1411 411 1.41 1149 149 1.14 81% 81 (81% intervalo 74 514 51 51,4 masculino 24 2, OR 242 42 IC 95 176 76 1,7 3,39 339 39 3,39] 0,001 0001 001 257 57 2,5 184 84 1,8 3,65, 365 3,65 , 65 3,65]) 252 52 180 80 3,58 358 58 3,58] 223 23 2,2 159 59 1,5 3,19. 319 3,19 19 3,19]) Idade Conclusões teleECG clínicas (hipertensão/diabetes 00 0,0 141 41 1.4 114 14 1.1 8 (81 7 51, 9 1, 3,3 33 0,00 000 25 18 36 3,6 3,65] 3,5 35 22 31 3,1 3,19] 0, 1. 11 (8 3, (

In higher education, reasonable accommodations are increasingly made for students with a wide range of disabilities. However, rigorous assessment is paramount to ensure these students are supported while preventing ineligible students from gaining unfair advantages. In this context, we sought to identify under which circumstances a university student should be allowed academic accommodation for attention-deficit/hyperactivity disorder (ADHD) and to outline an evidence-based policy for use in Brazil based on the global experience. We reviewed the literature to acquire information on what documents are commonly required by disability services before accommodations for ADHD are provided (including detection of malingering) and scrutinized the eligibility criteria of leading universities worldwide. Finally, renowned experts in the field and national stakeholders were consulted. Despite an exhaustive search, we found no international standard for the assessment of students with ADHD who request academic accommodation; even renowned institutions worldwide differ in their approaches to granting accommodations on the grounds of ADHD. Therefore, we propose a unified set of nationwide criteria for Brazilian universities, which could be generalized internationally. Higher education institutions in Brazil and beyond may benefit from adoption of such criteria. disabilities However advantages context attentiondeficit/hyperactivity attentiondeficithyperactivity attention deficit/hyperactivity deficit hyperactivity (ADHD evidencebased evidence experience including malingering Finally consulted search Therefore internationally attentiondeficit deficithyperactivity

In this work, cellulose-based composite biofilms doped with silver nanoparticles (AgNPs) have been produced by eco-friendly process. The AgNPs were synthesized from Ilex paraguariensis with an average size of 45 nm, a characteristic plasmon band at 450 nm and zeta potential of -23 mV. The biofilm has been synthesized by casting method, using different volumes of AgNPs suspension with glycerol plasticizing agent (T6-T10) or not (T1-T5). The AgNPs were successfully incorporated into the biofilms, which was confirmed by scanning electron microscopy. The mechanical and optical structural and the antimicrobial properties of the biofilms have been determined. In the presence of AgNPs, the mechanical properties, thermal stability and water vapor barrier of the biofilms have not been altered. However, the addition of glycerol decreased the tensile strength and the modulus of elasticity, in addition to increasing the elongation of the biofilms and the water vapor barrier. The biofilm T10 showed a transmittance of ca. 10%, with high potential to be used as a UV light blocker. Finally, the biofilms doped with AgNPs showed activity against the bacterium Pseudomonas fluorescens. Given the above, this work presented a new biofilm with activity against the bacterium Pseudomonus fluorescens obtained by eco-friendly process. cellulosebased cellulose based (AgNPs ecofriendly eco friendly process 4 23 -2 mV method T6T10 TT T6 T (T6-T10 T1T5. T1T5 T1 T5 . (T1-T5) microscopy determined altered However elasticity ca 10 10% blocker Finally above 2 - T6T1 (T6-T1 T1T (T1-T5 1 T6T (T6-T (T1-T

ABSTRACT This study aimed to evaluate the effect of water supply and sowing time on yield and yield components of two corn hybrids grown during offseason in the region of Dourados-MS, Brazil. The experimental design was randomized blocks in sub-divided plots, with four replications. In the main plot, two sowing dates were defined (2013 crop year: February 27 and March 27; and 2014 crop year: March 18 and April 5). In subplots, irrigation management systems were defined (irrigated and rainfed). Hybrids AS 1555 and AS 1590 were grown in the sub-plots. The parameters evaluated were plant height, ear insertion height, stem diameter, ear length and diameter, 100-grain weight, and grain yield. Regardless of irrigation and hybrid used, sowing time significantly affected corn yield, which responded to climate changes throughout crop cycle. Water supply increased corn yield, with the highest value being of 9338 kg ha-1 (156 bags ha-1) and obtained when irrigated AS 1555 hybrid was sown on February 27, 2013. DouradosMS, DouradosMS Dourados MS, MS Dourados-MS Brazil subdivided sub divided plots replications plot 2013 (201 year 2 201 1 5. 5 . 5) subplots rainfed. rainfed rainfed) 155 159 subplots. plots. sub-plots height diameter 100grain 100 weight used cycle 933 ha1 ha ha- 156 (15 (20 20 15 10 93 (1 (2 9 (

ABSTRACT Increasing population and demand for animal-derived products has raised the need for improved efficiency in managing and controlling animal production. Given this context, the project aimed to develop a device that aids decision-making in animal production. A hardware system was designed for instant measurement of thermal well-being levels, light intensity, and air gas concentration. This hardware integrated DHT11 sensors, an LDR photoresistor, and an MQ-135 sensor. To validate the system, a 30-day experimental study was conducted in an industrial pig farming setting. The collected data was sent to the Thingspeak server using the HTTP protocol. Data management, filtering, and organization were optimized using developed treatment algorithms. The system presented information on air humidity, temperature, ammonia concentration, CO2 levels, luminosity, and enthalpy through interactive images on a dashboard. In the case of a risk situation, the system automatically notified users with an "ALERT" message, facilitating prompt and efficient management response, and minimizing losses. The sensor calibration process yielded a high coefficient of determination (r2 = 0.98). Thus, the developed IoT device represents a viable solution, providing precise environmental conditions to support producers and enhance their efficiency and sustainability. animalderived derived production context decisionmaking decision making wellbeing well being levels intensity concentration DHT DHT1 sensors photoresistor MQ135 MQ 135 MQ-13 30day day 30 setting protocol filtering algorithms humidity temperature CO luminosity dashboard situation ALERT "ALERT message response losses r2 r (r 0.98. 098 0.98 . 0 98 0.98) Thus solution sustainability MQ13 13 MQ-1 3 09 0.9 9 MQ1 1 MQ- 0.

The present work aimed at evaluating indicators of hydrocarbon sources to sediments from the Solimões River region, in the central Amazon. The 16PAH, the alkylated homologs and molecular markers were investigated. The entire series of alkylated PAH were present and, in some cases, with a distribution observed when oil residues dominate. Nevertheless, hopanes characterizing immature environments undergoing diagenetic transformation were identified in samples from the Solimões River and in surface as well as in core sediment samples from Preto Lake, in the Coari-Manaus stretch. Investigation suggests early diagenesis of the organic matter confirmed by identifying biogenic markers produced during organic matter transformation. Some of these markers derive from incomplete combustion of biomass and are contained in particulate matter formed during forest burning. In the sediments of an industrial area near the city of Manaus, the entire series of mature hopanes was present indicating anthropogenic source of hydrocarbons. The results so far obtained point out the complexity of PAH source appraisal. region Amazon 16PAH investigated cases dominate Nevertheless Lake CoariManaus Coari Manaus stretch burning hydrocarbons appraisal

ABSTRACT Objective: Analyze craving in smokers with cardiovascular comorbidities submitted to a nutritional approach. Methods: Two groups were randomized and submitted to clinical intervention (n = 32): Group 1 (G1, n = 15): ingested 40 g of chocolate containing 70% cocoa/day and behavioral intervention for smoking cessation for one month; Group 2 (G2, n = 17): control group, only behavioral intervention. Questionnaire of Smoking Urges-Brief (QSU-Brief) - Brazil version measured total craving and its factors. Anthropometric measurements verified the nutritional interference of the procedure and the serum assessment verified the interference of inflammatory processes related to smoking. The study was registered on the Brazilian Registry of Clinical Trials (ReBEC): RBR-83jr3. Results: After one month, compared to the initial evaluation, the G1 reduced the craving evaluated by the QSU-Brief and its Factors 1 and 2. Total QSU-Brief: 44.27 ± 15.82 x 27.00 ± 18.03 (p = 0.008); Factor 1: 21.90 ± 7.70 x 12.90 ± 8.87 (p = 0.006); Factor 2: 11.90 ± 6.30 x 7.00 ± 6.63 (0.007). G2 showed a reduction in total QSU-Brief and Factor 1, but not in Factor 2. QSU-Brief total 28.17 ± 17.24 x 19.52 ± 9.50 (p = 0.049); Factor 1: 14.47 ± 8.74 x 9.23 ± 6.11 (p = 0.046). Serum levels of cortisol, leptin, serotonin, C-Reactive Protein (CRP) and insulin did not show differences (p > 0.05). No anthropometric differences were found. Conclusion: The results demonstrate that daily consumption of chocolate for one month (70%) reduced craving in smokers at the beginning of treatment. Chocolate potentiated the well-known effect of behavioral counseling on Factor 1 (pleasurable drug effects) and also interfered with factor 2 (unpleasant withdrawal effects). Objective approach Methods 32 32) G1, G (G1 15 15) 4 70 cocoaday cocoa day G2, (G2 17 17) group UrgesBrief Urges Brief QSUBrief QSU (QSU-Brief factors ReBEC (ReBEC) RBR83jr3. RBR83jr3 RBRjr RBR 83jr3. 83jr3 jr RBR-83jr3 Results evaluation 4427 44 27 44.2 1582 82 15.8 2700 00 27.0 1803 18 03 18.0 p 0.008 0008 0 008 0.008) 2190 21 90 21.9 770 7 7.7 1290 12 12.9 887 8 87 8.8 0.006 0006 006 0.006) 1190 11 11.9 630 6 30 6.3 700 7.0 663 63 6.6 0.007. 0007 0.007 . 007 (0.007) 2817 28 28.1 1724 24 17.2 1952 19 52 19.5 950 9 50 9.5 0.049 0049 049 0.049) 1447 14 47 14.4 874 74 8.7 923 23 9.2 611 6.1 0.046. 0046 0.046 046 0.046) cortisol leptin serotonin CReactive C Reactive CRP (CRP 0.05. 005 0.05 05 0.05) found Conclusion (70% treatment wellknown well known pleasurable effects unpleasant effects. 3 (G (ReBEC RBR83jr 83jr RBR-83jr 442 44. 158 15. 270 27. 180 18. 0.00 000 219 21. 77 7. 129 12. 88 8. 119 11. 6. 66 (0.007 281 28. 172 17. 195 5 19. 95 9. 0.04 004 04 144 14. 92 61 0.0 (70 (0.00 0. (7 (0.0 ( (0. (0

RESUMO Objetivo: Analisar o craving em fumantes com comorbidades cardiovasculares submetidos a uma abordagem nutricional. Métodos: Intervenção clínica (n = 32) com dois grupos randomizados: Grupo 1 (G1, n = 15): recebendo 40 g de chocolate contendo 70% de cacau/dia e intervenção comportamental para cessação do tabagismo por um mês; Grupo 2 (G2, n = 17): grupo controle, recebendo apenas intervenção comportamental pelo mesmo período. O Questionnaire of Smoking Urges-Brief (QSU-Brief) – versão Brasil foi utilizado para avaliar o craving. As medidas antropométricas verificaram a interferência nutricional do procedimento e a avaliação sérica, a interferência de processos inflamatórios relacionados ao tabagismo. O estudo foi registrado no Registro Brasileiro de Ensaios Clínicos (ReBEC), RBR-83jr3. Resultados: Um mês depois, comparado à avaliação inicial, o G1 reduziu o craving total e seus fatores (1 e 2). QSU-Brief total: 44,27 ± 15,82 x 27,00 ± 18,03 (p = 0,008); Fator 1: 21,90 ± 7,70 x 12,90 ± 8,87 (p = 0,006); Fator 2: 11,90 ± 6,30 x 7,00 ± 6,63 (0,007). G2: redução no QSU-Brief total e Fator 1, mas não no Fator 2. QSU-Brief total 28,17 ± 17,24 x 19,52 ± 9,50 (p = 0,049); Fator 1: 14,47 ± 8,74 x 9,23 ± 6,11 (p = 0,046). Níveis séricos de cortisol, leptina, serotonina, proteína C-reativa (PCR) e insulina não apresentaram diferenças (p > 0,05). Não foram encontradas diferenças antropométricas significativas. Conclusão: Os resultados demonstram que o consumo diário de chocolate por um mês (70%) reduziu o craving em fumantes no início do tratamento. O chocolate potencializou o conhecido efeito do aconselhamento comportamental sobre o Fator 1 (efeitos prazerosos da droga) e também interferiu no fator 2 (efeitos desagradáveis da abstinência). Objetivo Métodos 32 randomizados G1, G (G1 15 15) 4 70 cacaudia cacau dia G2, G2 (G2 17 17) controle período UrgesBrief Urges Brief QSUBrief QSU (QSU-Brief sérica ReBEC, ReBEC , (ReBEC) RBR83jr3. RBR83jr3 RBRjr RBR 83jr3. 83jr3 jr RBR-83jr3 Resultados depois inicial ( . 2) 4427 44 27 44,2 1582 82 15,8 2700 00 27,0 1803 18 03 18,0 p 0,008 0008 0 008 0,008) 2190 21 90 21,9 770 7 7,7 1290 12 12,9 887 8 87 8,8 0,006 0006 006 0,006) 1190 11 11,9 630 6 30 6,3 700 7,0 663 63 6,6 0,007. 0007 0,007 007 (0,007) 2817 28 28,1 1724 24 17,2 1952 19 52 19,5 950 9 50 9,5 0,049 0049 049 0,049) 1447 14 47 14,4 874 74 8,7 923 23 9,2 611 6,1 0,046. 0046 0,046 046 0,046) cortisol leptina serotonina Creativa C reativa PCR (PCR 0,05. 005 0,05 05 0,05) significativas Conclusão (70% tratamento efeitos droga abstinência. abstinência abstinência) 3 (G (ReBEC RBR83jr 83jr RBR-83jr 442 44, 158 15, 270 27, 180 18, 0,00 000 219 21, 77 7, 129 12, 88 8, 119 11, 6, 66 (0,007 281 28, 172 17, 195 5 19, 95 9, 0,04 004 04 144 14, 92 61 0,0 (70 (0,00 0, (7 (0,0 (0, (0

ABSTRACT Sugarcane is one of Brazil's leading crops, and the transshipment harvesting operation represents a significant portion of operating costs. Among the primary machines used in harvesting is the tractor-transshipment set, with considerable energy demands. This study focused on evaluating the gear selection effect in an agricultural tractor on operational performance and costs during the sugarcane transshipment operation. The treatments consisted of four operational work gears at different engine speeds: r1 – 1150 rpm, r2 – 1230 rpm, r3 – 1360 rpm, and r4 – 1500 rpm on the engine. The analyzed variables were volumetric and specific fuel consumption, operational efficiency, and operational cost. The variables were adapted from ASABE (2011) methodology, and the data were submitted to parametric statistics and regression analysis. The rotation engine selection in tractors directly affected fuel consumption with positive angular coefficients and r2 between 0.92-0.96. Fuel consumption reduces by 37.5%, adopting 1150 rpm compared to 1500 rpm rotation. The highest rotation (1500 rpm - r4) increased the volumetric and productive fuel consumption, enabling savings up to reduced fuel cost by 1.08 US$ ha -1 . Thus, training sugarcane transshipment operators is essential to optimize the production process efficiency and reduce costs. Brazils Brazil s crops tractortransshipment set demands speeds r 115 123 136 150 2011 (2011 methodology analysis 0.920.96. 092096 0.92 0.96. 0 92 96 0.92-0.96 375 37 5 37.5% (150 108 1 08 1.0 US Thus 11 12 13 15 201 (201 920 0.920.96 09209 092 0.9 096 0.96 9 0.92-0.9 3 37.5 (15 10 1. 20 (20 0.920.9 0920 09 0. 0.92-0. 37. (1 2 (2 0.920. 0.92-0 ( 0.920 0.92-

OBJECTIVES: Despite higher rates of sustained virologic response (SVR), important concerns remain when patients with decompensated cirrhosis due to hepatitis C virus (HCV) are treated with direct-acting antiviral agents (DAA). Questions include efficacy, safety, and the magnitude of liver function improvement. Here, we aimed to evaluate HCV treatment data in this specific population in Brazil. METHODS: We included 85 patients with decompensated cirrhosis submitted to HCV therapy with DAA followed at two academic tertiary centers in the southeastern region of Brazil. RESULTS: Seventy-nine patients (92.9%) were Child-Pugh (CP) score B, and six (7.1%) were CP score C. The mean MELD score was 12.86. The most common treatment was sofosbuvir plus daclatasvir±ribavirin for 24 weeks. The overall intention-to-treat (ITT) SVR rate was 87.4% (74/85) and modified-ITT 96.1% (74/77). ITT SVR was associated with lower baseline INR values (p=0.029). Adverse events (AE) occurred in 57.9% (44/76) of patients. Serious AE were reported in 12.8% (10/78), and were related to the presence of hepatic encephalopathy (p=0.027). SVR was associated with improvement in CP (p<0.0001) and MELD scores (p=0.021). Among baseline CP score B patients with SVR, 46% (29/63) regressed to CP score A. Ascites was independently associated with no improvement in liver function in patients who achieved SVR (p=0.001; OR:39.285; 95% CI:4.301-258.832). CONCLUSIONS: Patients with decompensated HCV cirrhosis showed a high SVR rate with interferon-free therapy. Early liver function improvement occurred after successful HCV eradication. However, long-term follow-up of these patients after SVR remains strongly advised.

RESUMO No momento da compra, a maioria dos consumidores de abacaxi apontam a qualidade do produto como fator determinante na decisão. Assim, objetivou-se com esse trabalho, avaliar o efeito da adubação foliar na qualidade dos frutos de cinco cultivares de abacaxizeiro. O delineamento experimental foi em blocos casualizados, com quatro repetições, em esquema de parcelas subdivididas. Nas parcelas foram aleatorizadas cinco cultivares de abacaxizeiro e nas subparcelas, três composições de adubo foliar. As adubações foram realizadas quinzenalmente, de forma localizada. A colheita dos frutos teve início aos 360 dias após o plantio das mudas no campo. Os frutos foram conduzidos para o laboratório para análise das variáveis: Massa, comprimento, diâmetro, firmeza e pH do fruto, sólidos solúveis, acidez titulável, relação sólidos solúveis e acidez titulável e rendimento médio de suco. De modo geral, quando adubada com NK, a cultivar que apresentou maior média de massa do fruto foi a Vitória porém, sem diferença significativa para a cultivar Fantástico. A fórmula NK é a melhor opção para utilização como adubo foliar na cultura do abacaxizeiro para as condições e cultivares deste estudo. Todas as cultivares, independentemente da fórmula de adubação, apresentam teores de suco dentro do padrão de exportação para fins industriais.

ABSTRACT At the time of purchase, most pineapple consumers point to product quality as a determining factor in the decision. Thus, the objective of this work was to evaluate the effect of foliar fertilization on the quality of the fruits of five pineapple cultivars. The experimental design was in randomized blocks, with four replications, in a split plot scheme. In the plots, five pineapple cultivars were randomized and in the subplots, three leaf fertilizer compositions. Fertilizations were carried out fortnightly, in a localized manner. Fruit harvest started 360 days after planting seedlings in the field. The fruits were taken to the laboratory for analysis of the variables: Mass, length, diameter, firmness and pH of the fruit, soluble solids, titratable acidity, soluble solids and titratable acidity ratio and average juice yield. In general, when fertilized with NK, the cultivar that presented the highest average mass of the fruit was Vitória, however, with no significant difference for the cultivar Fantástico. The NK formula is the best option for use as leaf fertilizer in pineapple cultivation for the conditions and cultivars of this study. All cultivars, regardless of the fertilization formula, have juice levels within the standard of export for industrial purposes.

ABSTRACT Plants that occur in arid or semi-arid environments may restrict their flowering to the rainy season to ensure water availability for reproductive functions. However, the exposure of flowers to rainfall can compromise their functionality, such as complex self-pollination mechanisms. We experimentally tested how rainfall exposure affects the sequence of anthesis and reproductive success of Pavonia varians. This species is endemic to the Caatinga, and it has a rainfall-dependent flowering and a specialized mechanism of delayed self-pollination by style curvature. Our results demonstrate that wet flowers have difficulty in distending their petals, and although they maintain the sequence of anthesis, style curvature and corolla closure are delayed. Water exposure also compromised reproductive success by spontaneous self-pollination in bagged flowers but did not prevent fruit set by exposed flowers. These conditions allow cross-pollination in P. varians if rainfall is transient or localized, which is a common condition in the Caatinga. We believe that this type of experimental approach can bring important clues about how reproductive systems respond to abiotic factors, especially in the context of imminent climate change.