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Abstract This longitudinal study aimed to investigate the association between self-perceived oral health, oral-health-related quality-of-life (OHRQoL), toothache, and university students’ academic performance or dropout. A cohort of 2,089 students from 64 different courses at a public university in southern Brazil was interviewed in 2016 regarding their self-perceived oral health (Locker instrument; dichotomized into good/poor), OHRQoL (Oral Impacts on Daily Performances instrument, OIDP) and having had any toothache over the last 6 months (yes/no). After three years (2020), the academic records of 1,870 of these students were assessed, their average grade over all courses evaluated, and their dropout status was determined. Multivariable linear or logistic regression adjusting for gender, skin color, age, family income and maternal education was used to associate oral health variables (self-perceived oral health, OIDP, toothache) and academic performance or dropout. In 2016, 28.6% reported negative self-perceived oral health through the Locker instrument and 31.4% had toothache in the last 6 months. Over the next three years, 36.2% had dropped out. In multivariable regression, toothache in the last 6 months had a decrease of 0.32 (β -0.32, CI95% -0.59; -0.04) points in the final grade and were 35% (OR 1.35 CI95% 1.08; 1.69) more likely to dropout than students without toothache. In conclusion, this study showed that worse oral health conditions may be associated with worse academic performance or dropping out. selfperceived self perceived oralhealthrelated related qualityoflife quality life OHRQoL, , (OHRQoL) 2089 2 089 2,08 201 good/poor, goodpoor good/poor good poor good/poor) Oral OIDP yes/no. yesno yes/no . yes no (yes/no) 2020, 2020 (2020) 1870 1 870 1,87 assessed evaluated determined gender color age 286 28 28.6 314 31 4 31.4 362 36 36.2 out 032 0 32 0.3 β 0.32, -0.32 CI95 CI 0.59 059 59 -0.59 0.04 004 04 -0.04 35 OR 135 1.3 1.08 108 08 1.69 169 69 conclusion (OHRQoL 208 2,0 20 (yes/no 202 (2020 187 87 1,8 28. 3 31. 36. 03 0. -0.3 CI9 0.5 05 5 -0.5 0.0 00 -0.0 13 1. 1.0 10 1.6 16 2, (202 18 8 1, -0. (20 -0 (2 - (