ABSTRACT BACKGROUND: Patients with severe coronavirus disease 2019 (COVID-19) often require hospital admission and experience sequelae such as chronic fatigue or low muscle mass. OBJECTIVE: To analyze the functional capacity of a cohort of patients with severe acute respiratory syndrome coronavirus 2 who required hospitalization. DESIGN AND SETTING: An observational descriptive study was conducted on post-COVID-19 patients referred to the Rehabilitation Department of Gregorio Marañón Hospital (Madrid, SPAIN). METHODS: Cardiorespiratory fitness, muscle strength, body composition, and perception of fatigue and dyspnea were analyzed. Furthermore, the existing correlations between clinical variables and physical conditions were analyzed. RESULTS: Forty-two patients who required hospital admission (80 ± 22.45 days) or intensive care unit (ICU) admission (58 ± 10.52 days) were analyzed. They presented with decreased strength, respiratory capacity, and moderate-to-severe perceived fatigue. Additionally, an inverse correlation was found between right-handgrip strength and days in the ICU, as well as the 6-minute walk test for women. Similarly, strength and fitness were negatively associated with perceived fatigue. CONCLUSIONS: Post-COVID-19 patients showed low muscle function and low levels of physical fitness associated with high perceived fatigue. BACKGROUND 201 COVID19 COVID 19 (COVID-19 mass OBJECTIVE hospitalization SETTING postCOVID19 postCOVID post post-COVID-1 Madrid, Madrid (Madrid SPAIN. SPAIN . SPAIN) METHODS composition analyzed Furthermore RESULTS Fortytwo Forty two 80 (8 2245 22 45 22.4 ICU (ICU 58 (5 1052 10 52 10.5 moderatetosevere moderate Additionally righthandgrip right handgrip 6minute minute 6 women Similarly CONCLUSIONS PostCOVID19 PostCOVID Post Post-COVID-1 20 COVID1 1 (COVID-1 postCOVID1 post-COVID- 8 ( 224 4 22. 5 105 10. PostCOVID1 Post-COVID- (COVID- post-COVID Post-COVID (COVID

ABSTRACT BACKGROUND: Neck circumference (NC) is a useful anthropometric measure for predicting obstructive sleep apnea (OSA). Ethnicity and sex also influence obesity phenotypes. NC cut-offs for defining OSA have not been established for the Latin American population. OBJECTIVES: To evaluate NC, waist circumference (WC), and body mass index (BMI) as predictors of OSA in the Colombian population and to determine optimal cut-off points. DESIGN AND SETTING: Diagnostic tests were conducted at the Javeriana University, Bogota. METHODS: Adults from three cities in Colombia were included. NC, WC, and BMI were measured, and a polysomnogram provided the reference standard. The discrimination capacity and best cut-off points for diagnosing OSA were calculated. RESULTS: 964 patients were included (57.7% men; median age, 58 years) and 43.4% had OSA. The discrimination capacity of NC was similar for men and women (area under curve, AUC 0.63 versus 0.66, P = 0.39) but better for women under 60 years old (AUC 0.69 versus 0.57, P < 0.05). WC had better discrimination capacity for women (AUC 0.69 versus 0.57, P < 0.001). There were no significant differences in BMI. Optimal NC cut-off points were 36.5 cm for women (sensitivity [S]: 71.7%, specificity [E]: 55.3%) and 41 cm for men (S: 56%, E: 62%); and for WC, 97 cm for women (S: 65%, E: 69%) and 99 cm for men (S: 53%, E: 58%). CONCLUSIONS: NC and WC have moderate discrimination capacities for diagnosing OSA. The cut-off values suggest differences between Latin- and North American as well as Asian populations. BACKGROUND (NC . (OSA) phenotypes cutoffs cut offs OBJECTIVES , (WC) (BMI cutoff off SETTING University Bogota METHODS measured standard calculated RESULTS 96 57.7% 577 57 7 (57.7 age 5 434 43 4 43.4 area curve 063 0 63 0.6 066 66 0.66 0.39 039 39 6 069 69 057 0.57 0.05. 005 0.05 05 0.05) 0.001. 0001 0.001 001 0.001) 365 36 36. sensitivity S [S] 717 71 71.7% E [E] 55.3% 553 55 3 (S 56 56% 62% 62 62%) 9 65 65% 69% 53 53% 58%. 58% 58%) CONCLUSIONS populations (OSA (WC 57.7 (57. 43. 06 0. 0.3 03 0.5 00 0.0 000 0.00 [S 71.7 [E 55.3 57. (57 71. 55. (5 (

Abstract This review aimed to determine the prevalence of species of yellow, purple and green microbial complexes in root canals (RC) and periodontal pockets (PP) of teeth with endodontic-periodontal lesions. For this purpose, two reviewers searched the literature up to January 2022. Studies reporting the prevalence of species of the yellow, purple and green microbial complexes in teeth diagnosed with endodontic-periodontal lesions were included. The risk of bias of the included studies was assessed using the 14 criteria from the NIH Quality Assessment Tool. Of 1,611 references identified in the initial search, only four studies were eligible and included in the qualitative analysis. The profile and prevalence rates of bacterial species in RC and PP varied among the included studies: levels of Agregatibacter actinomycetemcomitans (12% RC, 58% PP), Capnocytophaga granulosa (10% RC, 35% PP), Capnocytophaga sputigena (15-70% RC, 0-30% PP), Streptococcus mitis (30% RC, 35% PP), Streptococcus sanguinis (30% RC, 35% PP), and Veillonella parvula (70% RC, 50% PP) were identified. The high methodological heterogeneity prevented grouping and quantitative analysis of data. The risk of bias was considered ‘moderate’ for all studies. The included studies identified the presence of seven bacterial species belonging to the yellow, purple, and green microbial complexes in RC and PP, but with different prevalence rates. Future clinical studies are encouraged to investigate the presence and role of these species in the occurrence and development of endodontic-periodontal lesions. yellow (RC (PP endodonticperiodontal endodontic purpose 2022 1 Tool 1611 611 1,61 search 12% 12 (12 58 , 10% 10 (10 35 1570% 1570 15 70% 70 (15-70 030% 030 0 30% 30 0-30 (30 (70 50 data ‘moderate moderate 202 161 61 1,6 (1 5 3 157 7 (15-7 03 0-3 (3 (7 20 16 6 1, ( (15- 0- 2 (15

ABSTRACT BACKGROUND: Smoking and unhealthy diet are important risk factors for cardiovascular and metabolic diseases, contributing to public health crises. OBJECTIVE: To evaluate the consumption of natural/minimally processed and ultra-processed foods by Brazilian adults (18–59 years old) according to smoking status. DESIGN AND SETTING: Cross-sectional study of a representative population sample from 26 state capitals and the Federal District (Brazil-2018). METHODS: Data were obtained from Vigitel—Surveillance System for Risk and Protection Factors for Chronic Diseases by Telephone Survey. Participants were categorized as smokers, ex-smokers, and never smokers. Multinomial logistic regression was used for analyses. RESULTS: Of the 30,800 adults evaluated, 9.4% (95%CI: 8.7-10.2) were smokers and 16.5% (95%CI: 15.8-17.3) were ex-smokers. Smokers were less likely to consume fruit and natural juice, and more likely to consume soda or artificial juice (≥ 5 days/week) than ex-smokers and never smokers. Regarding the daily frequency of consumption, smokers were observed to be less likely to eat fruit more than 1 time/day and more likely to drink ≥ 3 cups/cans of soda/day. Compared to never smokers, smokers had a 42% higher chance of consuming ≥ 3 glasses of natural juice/day. On the day before the interview, fruit, milk, tubers, squash, and okra consumption were lower among smokers than non-smokers. Smokers were more likely to report consuming soft drinks, fruit juice, sauces, ready-made dishes, margarine, and sausages. CONCLUSION: Smokers had lower fruit consumption, and higher consumption of natural juices and ultra-processed foods. We highlight the need for strategies that encourage healthy eating and smoking cessation. BACKGROUND diseases crises OBJECTIVE naturalminimally minimally ultraprocessed ultra 18–59 1859 18 59 (18–5 old status SETTING Crosssectional Cross sectional 2 Brazil2018. Brazil2018 Brazil 2018 . (Brazil-2018) METHODS VigitelSurveillance Vigitel Surveillance Survey exsmokers, exsmokers ex analyses RESULTS 30800 30 800 30,80 evaluated 94 9 4 9.4 95%CI 95CI CI 95 (95%CI 8.710.2 87102 8.7 10.2 8 7 10 8.7-10.2 165 16 16.5 15.817.3 158173 15.8 17.3 15 17 15.8-17.3 exsmokers. ( days/week daysweek days week timeday time cupscans cups cans sodaday soda/day 42 juiceday juice/day interview milk tubers squash nonsmokers. nonsmokers non non-smokers drinks sauces readymade ready made dishes margarine sausages CONCLUSION cessation 18–5 185 (18– Brazil201 201 (Brazil-2018 3080 80 30,8 9. 710 8.710. 8710 87 8. 102 10. 8.7-10. 16. 817 15.817. 15817 158 15. 173 17. 15.8-17. 18– (18 Brazil20 20 (Brazil-201 308 30, 71 8.710 871 8.7-10 81 15.817 1581 15.8-17 (1 Brazil2 (Brazil-20 8.71 8.7-1 15.81 15.8-1 (Brazil-2 8.7- 15.8- (Brazil- (Brazil

RESUMO A cidade de São Paulo possui três viveiros municipais de distribuição de exemplares de plantas que atendem à demanda de seus projetos paisagísticos e o aumento da cobertura arbórea. Um deles (Manequinho Lopes) recebe mudas de árvores pelos processos de compensação ambiental contratados pela Secretaria Municipal do Verde e Meio Ambiente (SVMA). Este trabalho teve como objetivo avaliar o cenário da biodiversidade arbórea recebida entre julho de 2013 e julho de 2018 pelo viveiro Manequinho Lopes, como medida de compensação ambiental. Os resultados indicaram que 144.727 mudas de árvores foram recebidas pelo viveiro, com aproximadamente 80% do total pertencendo a apenas 30 espécies, sendo que metade delas pertencem a apenas 10 grupos diferentes. Encontramos apenas duas famílias predominantes: Myrtaceae e Bignoniaceae, evidenciando o futuro risco de homogeneização biótica. Em relação aos atributos ecológicos, constatou-se que 33% das espécies eram zoocóricas, 16% autocóricas e 22% anemocóricas. A maioria deles eram espécimes não ameaçados de extinção. Lopes SVMA. SVMA . (SVMA) 201 144727 144 727 144.72 80 3 1 diferentes predominantes Bignoniaceae biótica ecológicos constatouse constatou se 33 zoocóricas 16 22 anemocóricas extinção (SVMA 20 14472 14 72 144.7 8 2 1447 7 144.

ABSTRACT São Paulo city has three municipal nurseries for the distribution of urban tree specimens that meet the demand for its public landscape projects and increase in tree covering. One of them (Manequinho Lopes) receives tree seedlings from the environmental compensation processes contracted with the Municipal Secretariat for Green and Environment (MSGE). This paper aimed to evaluate the scenario of tree biodiversity received between July 2013 and July 2018 by the Manequinho Lopes nursery, as a measure of environmental compensation. The results indicated that 144,727 tree seedlings were received by the nursery, with approximately 80% of the total belonging to only 30 species, half of them belonging to only 10 different groups. We found just two predominated families: Myrtaceae and Bignoniaceae, highlighting a biotic homogenization risk. Regarding ecological attributes, it was found that 33% of the species were zoochoric, 16% autochorous and 22% anemochoric. Most of them were non-endangered specimens. covering MSGE. MSGE . (MSGE) 201 nursery 144727 144 727 144,72 80 3 1 groups families Bignoniaceae risk attributes 33 zoochoric 16 22 anemochoric nonendangered non endangered (MSGE 20 14472 14 72 144,7 8 2 1447 7 144,

ABSTRACT Purpose: to present a method to enhance enzymatic hydrolysis of biomass, hydrothermal treatment. Methods: It was used Teflon bomb, fed with rice straw and water, to extract reducing sugars by hydrothermal treatment. Conditions were analysed using design of experiment procedure and ANOVA. The hydrothermal conditions were 140 and 200 °C, 20 and 60 min and 62,5 and 71,42 g straw per kilogram of water. The straw was filtered, dried and submitted to enzymatic hydrolysis; the conditions were 24 and 72 h, solid/liquid ratio were 0,625 and 2,50 % w/v and enzyme loading 16,5 and 66 FPU · g-1. Results: It was observed best yields of Reducing Sugars when submitting the Teflon bomb to 200 °C temperature for 60 min and 62,5 g straw per kg of water (pressure of 15,5 atm). The conditions for the enzymatic hydrolysis were 72 h and enzyme loading of 66 FPU · g-1. The enzymatic yield was 42,72 %.

RESUMEN Propósito: presentar un método para potenciar la hidrólisis enzimática de biomasa, tratamiento hidrotermal. Métodos: Se utilizó bomba de teflón, alimentada con paja de arroz y agua, para extraer azúcares reductores por tratamiento hidrotermal. Las condiciones se analizaron usando el procedimiento de diseño de experimento y ANOVA. Las condiciones hidrotermales fueron 140 y 200 °C, 20 y 60 min; y 62,5, y 71,42 g de paja por kg de agua. La paja fue filtrada, secada y sometida a hidrólisis enzimática; las condiciones fueron 24 y 72 h, relación sólido/líquida 0,625 y 2,50 % p/v y carga de enzima 16,5 y 66 FPU · g-1. Resultados: Se observaron mejores rendimientos de azúcares reductores al someter la bomba de teflón a una temperatura de 200 °C durante 60 min y 62,5 g de paja por kg de agua (presión de 15,5 atm). Las condiciones para la hidrólisis enzimática fueron 72 h y carga enzimática de 66 FPU · g-1. El rendimiento enzimático fue del 42,72 %.

Resumen Introducción: El trasplante renal es el tratamiento de elección de la enfermedad renal en etapa terminal (ERT). Desde marzo de 2020, la actividad de trasplantes en México se ha visto afectada debido a la pandemia de COVID-19. Objetivo: Determinar el impacto en la mortalidad de pacientes en lista de espera (LE) para trasplante renal de donante cadavérico en un hospital de referencia en Yucatán, por suspensión de actividades debido a la pandemia. Material y métodos: Pacientes > 18 años en LE para trasplante renal en este hospital. En caso de muerte de un paciente, se investigó la causa, especialmente si estaba asociada a COVID-19. Un valor de p de dos colas ≤ 0.05 se consideró significativo en todos los análisis. Resultados: La razón de probabilidad de muerte por COVID-19 en un paciente con ERT en la LE en 2020 fue OR = 5.04 (IC 95%: 1.65-7.14, p = 0.023). La razón de probabilidad de morir con ERT en la LE con retraso en las consultas de seguimiento fue de OR = 6.59 (IC 95%: 2.7-16.28, p = 0.008). Conclusión: La probabilidad de muerte de un paciente con ERT en la LE con retraso en las consultas de seguimiento y retención del trasplante es estadísticamente más alta que la probabilidad de muerte por COVID-19.

Abstract Introduction: Kidney transplantation is the treatment of choice for end-stage renal disease (ESRD). Since March 2020, transplant activity in Mexico has been affected due to the COVID-19 pandemic. Objective: The aim of the study was to determine the impact on mortality of patients on the waiting list (WL) for cadaveric donor kidney transplantation in a referral hospital in Yucatán, due to suspension of activities due to the pandemic. Material and methods: Patients over 18 years of age on the waiting list for kidney transplantation at this hospital. In the event of a patient's death, the cause was investigated, especially if it was associated with COVID-19. A two-tailed p ≤ 0.05 was considered significant in all analyzes. Results: The odds ratio (OR) of death from COVID-19 in a patient with ESRD in the WL in 2020 was OR = 5.04 (95% CI: 1.65-7.14, p = 0.023). The OR of dying with ESRD in the WL with a delay in the follow-up visits was OR = 6.59 (95% CI: 2.7-16.28, p = 0.008). Conclusion: The probability of death of a patient with ESRD with delayed follow-up visits and transplant retention is statistically higher than the probability of death from COVID-19.

ABSTRACT Introduction: The mastopexy with implants and L-shaped scarring aims to correct grades I to II breast ptosis using implants in retroglandular space and retromuscular dual plane space, at the same surgical time. The objective is to describe the experience with the L-augmentation mastopexy technique, analyzing complications and reoperations. Methods: Retrospective study of 123 patients with mild to moderate breast ptosis, operated using the L-augmentation mastopexy technique from January 2011 to November 2021. Results: The mean age of patients was 35.6 years. The average volume of implants used was 315ml (range 175 to 600ml). The placement of the prosthesis was in retroglandular (46.5%) and dual plane retromuscular space (53.5%). The average operative time was two hours and fifty-four minutes. The main complications presented were superficial dehiscence (7.3%), recurrence of ptosis (7.3%) and unsightly scars (5.7%). Surgical reviews took place in 13 patients (10.5%). Conclusion: Safe and effective mastopexy technique with implant in the treatment of mild to moderate breast ptosis, providing well designed breasts with reduced L-shaped scars. Introduction Lshaped L shaped Laugmentation augmentation reoperations Methods 12 201 2021 Results 356 35 6 35. years ml range 17 600ml. 600ml . 600ml) 46.5% 465 46 5 (46.5% 53.5%. 535 53.5% 53 (53.5%) fiftyfour fifty four minutes 7.3%, 73 7.3% , 7 3 (7.3% 5.7%. 57 5.7% (5.7%) 1 10.5%. 105 10.5% 10 (10.5%) Conclusion 20 202 46.5 4 (46.5 53.5 (53.5% 7.3 (7.3 5.7 (5.7% 10.5 (10.5% 2 46. (46. 53. (53.5 7. (7. 5. (5.7 10. (10.5 (46 (53. (7 (5. (10. (4 (53 ( (5 (10 (1

RESUMO Introdução: A mastopexia com implantes e cicatriz em L visa corrigir ptoses mamárias graus I a II com utilização de implantes em espaço retroglandular e retromuscular dual plane, no mesmo tempo cirúrgico. O objetivo é descrever a experiência com a técnica de mastopexia de aumento em L, analisando complicações e reoperações. Método: Estudo retrospectivo de 123 pacientes com ptose mamária leve a moderada, operadas pela técnica de mastopexia de aumento em L no período de janeiro de 2011 a novembro de 2021. Resultados: A média de idade das pacientes foi de 35,6 anos. O volume médio de implantes utilizado foi de 315ml (variação de 175 a 600ml). O posicionamento da prótese foi em espaço retroglandular (46,5%) e retromuscular dual plane (53,5%). O tempo médio operatório foi de duas horas e cinquenta e quatro minutos. As principais complicações apresentadas foram deiscências superficiais (7,3%), recorrência da ptose (7,3%) e cicatrizes inestéticas (5,7%). Revisões cirúrgicas aconteceram em 13 pacientes (10,5%). Conclusão: Técnica de mastopexia com implante segura e eficaz no tratamento da ptose mamária leve a moderada, proporcionando mamas bem projetadas com cicatrizes reduzidas em L. Introdução cirúrgico reoperações Método 12 moderada 201 2021 Resultados 356 35 6 35, anos ml variação 17 600ml. 600ml . 600ml) 46,5% 465 46 5 (46,5% 53,5%. 535 53,5% 53 (53,5%) minutos 7,3%, 73 7,3% , 7 3 (7,3% 5,7%. 57 5,7% (5,7%) 1 10,5%. 105 10,5% 10 (10,5%) Conclusão 20 202 46,5 4 (46,5 53,5 (53,5% 7,3 (7,3 5,7 (5,7% 10,5 (10,5% 2 46, (46, 53, (53,5 7, (7, 5, (5,7 10, (10,5 (46 (53, (7 (5, (10, (4 (53 ( (5 (10 (1

ABSTRACT Objective To reduce surgical center idleness by analyzing the competitive structure of the surgical center in a hospital, and thereby generate value in operations and increase hospital revenue. Methods The study used qualitative and quantitative methods and an action research approach involving the surgical center leadership of a small private specialized hospital in southeastern Brazil. We used the Strengths, Weaknesses, Opportunities, and Threats or SWOT tool to analyze the competitive structure of the surgical center and then implemented interventions as proposed by the science of improvement method proposed by the Institute of Healthcare Improvement. Results By applying the SWOT tool, we identified a concentration of surgeries in the specialty of Otolaryngology and the need to establish a health management system to reduce the idleness of the operating rooms. Based on subsequent intervention, procedures from other specialties were inserted that increased surgical production by 2.62X, reduced idleness by 67.84%, and increased revenue by over US$ 276,609.87 in 2018 compared to the previous year 2017. Conclusion Investing in quality, surgical schedule management, and inducting new surgeons to the clinical staff resulted in decreased surgical idleness, increased production, better uniformity in scheduling, and increased revenue, while costs remained below the linear trend, allowing for increased profits. Brazil Strengths Weaknesses Opportunities Improvement rooms intervention 262X X 2 62X 2.62X 6784 67 84 67.84% US 27660987 276 609 87 276,609.8 201 2017 quality scheduling trend profits 678 6 8 67.84 2766098 27 60 276,609. 20 67.8 276609 276,609 67. 27660 276,60 2766 276,6 276,

ABSTRACT The term new museum idea is widely used in the historiography of natural history museums. However, there is no consensus regarding the ideas covered by the concept and, in some cases, there was a disconnection with its author and its origin. On the other hand, the new museum idea represents a synthesis on some topics of the reform that these institutions went through in the 19th century elaborated by one of its central thinkers. This study sought to elucidate the complexity of the term in its original formulation context, in the speech of the naturalist William Henry Flower (1831-1899) in the Museums Association’s meeting, in 1893. In doing so, we hope to advance in the more precise knowledge regarding the ideas of the period and its diverse actors. We also seek to shed light on the 19th century naturalists who resolved the challenges and took on the opportunities for museums, bequeathing us a new institutional model. Revisiting the 19th century, and its rich process of museological reflection, also inspires us to tackle on the new challenges of natural history museums in the 21st century, showing that some aspects that seemed guaranteed at the time, such as research and safeguarding of the collection, now deserve our special attention. The model of institution bequeathed to us underwent profound adaptations, serving an increasing number of citizens in the production of relevant knowledge, education, and communication. However cases origin hand th thinkers context 18311899 1831 1899 (1831-1899 Associations Association s meeting 1893 so actors reflection st time collection attention adaptations education communication 1831189 183 189 (1831-189 183118 18 (1831-18 18311 1 (1831-1 (1831- (1831 (183 (18 (1 (

RESUMO O termo nova ideia de museu é amplamente empregado na historiografia dos museus de história natural. Entretanto, existe uma falta de consenso quanto às ideias abrangidas pelo conceito e, em alguns casos, houve a desconexão com seu autor e sua origem. Por outro lado, a nova ideia de museu representa uma síntese sobre alguns tópicos da reforma que essas instituições passaram no século XIX elaborada por um de seus personagens centrais. Este artigo buscou elucidar a complexidade do termo em seu contexto de formulação original, no discurso do naturalista William Henry Flower (1831-1899), na reunião da Museums Association, em 1893. Ao fazê-lo, esperamos avançar no conhecimento mais preciso acerca das ideias do período e seus diversos autores. Buscamos igualmente lançar luz sobre como os naturalistas do século XIX superaram os desafios e aproveitaram as oportunidades oferecidas aos museus, legando-nos um novo modelo institucional. Revisitar o século XIX, e seu rico processo de reflexão museológica, contribui também para nossa reflexão quanto aos novos desafios dos museus de história natural no século XXI, mostrando que alguns aspectos que pareciam garantidos na época; como a pesquisa e a salvaguarda do acervo, hoje; merecem nossa atenção especial. O modelo de instituição que nos foi legado sofreu profundas adaptações, estando a serviço de um número cada vez maior de cidadãos na produção de conhecimento relevante, na educação e na comunicação. Entretanto casos origem lado centrais original 18311899, 18311899 1831 1899 , (1831-1899) Association 1893 fazêlo, fazêlo fazê lo, lo fazê-lo autores legandonos legando institucional museológica XXI época acervo hoje especial adaptações relevante comunicação 1831189 183 189 (1831-1899 183118 18 (1831-189 18311 1 (1831-18 (1831-1 (1831- (1831 (183 (18 (1 (

ABSTRACT Conservation agriculture principles applied to peanut can reduce soil erosion and production costs when cultivated in rotation with sugarcane. Still, the problem with soil compaction is the leading cause of skepticism about the efficacy of this practice. This research aimed to study the effect of three soil management strategies compared with conventional for peanut cv. IAC-OL3, cultivated in rotation with sugarcane using the MEIOSI (method of intercropping occurring simultaneously) system for agronomic practices with additional analysis on changes in soil physics properties. The trial was conducted in 2019-2020 in Planalto municipality (São Paulo, Brazil) under a green-harvested sugarcane field, using a randomized complete block experimental design. The trial consisted of four soil management treatments (conventional tillage, minimum tillage with chisel, strip-tillage, and no-tillage) with five replications. Although no differences were verified in soil bulk density and porosity among treatments, the highest values of soil penetration resistance were observed in no-tillage treatment for all evaluations (before planting, at the beginning of flowering, and before and after harvesting) in comparison with conventional tillage. The difference in soil penetration resistance among the treatments diminished from planting to the end of the cycle. Furthermore, low soil disturbance and maximum covering with straw significantly increased the available water capacity and reduced the incidence and severity of groundnut ringspot virus (GRSV) on peanut plants. Consequently, both minimum-tillage and no-tillage have increased the pod yield on average by 695 and 991 kg ha-1 more than strip-tillage and conventional tillage, respectively, without differences in terms of quality and pod losses. Still practice cv IACOL3, IACOL3 IACOL IAC OL3, OL3 OL IAC-OL3 method simultaneously properties 20192020 2019 2020 2019-202 São Paulo Brazil greenharvested green harvested field design chisel striptillage, striptillage strip notillage replications flowering harvesting cycle Furthermore GRSV (GRSV plants Consequently minimumtillage 69 99 ha1 ha 1 ha- respectively losses IAC-OL 2019202 201 202 2019-20 6 9 201920 20 2019-2 20192 2 2019-

Abstract In view of the morphological similarity between gastrointestinal stromal tumors (GIST) and other sarcomas of the intestine of dogs, the aim was to carry out the histomorphological and immunohistochemical diagnosis of these tumors, associating breed, sex and age, location and tumor invasion. 217 cases were evaluated by histopathology and 36 diagnosed by immunohistochemistry were included (24 GIST and 12 other intestinal sarcomas). Mixed breed dogs were the most diagnosed with GIST, mainly elderly females (9.5±2.2 years); in the other intestinal sarcomas, crossbreeds and Dachshunds, males and females, were equally affected. The cecum was the most affected by GISTs, with tumor invasion of the intestinal layers in all cases. The small intestine was the most affected by the other intestinal sarcomas, with invasion of the layers in most of these tumors. GISTs expressed markers such as CD117 and DOG-1, unlike other intestinal sarcomas. GIST and other intestinal sarcomas denoted histomorphological and immunophenotypic characteristics similar to histopathology, justifying the association of immunohistochemistry for the definitive diagnosis. (GIST age 21 3 24 (2 1 . sarcomas) 9.5±2.2 9522 9 5 2 (9.5±2. years years) Dachshunds CD CD11 DOG1, DOG1 DOG 1, DOG-1 ( 9.5±2. 952 (9.5±2 CD1 DOG- 9.5±2 95 (9.5± 9.5± (9.5 9.5 (9. 9. (9

Resumo Tendo em vista a semelhança morfológica entre tumores estromais gastrointestinais (GIST) e outros sarcomas do intestino de cães, objetivou-se realizar o diagnóstico histomorfológico e imunoistoquímico desses tumores, associando raça, sexo e idade, localização e invasão tumoral. Foram avaliados 217 casos por histopatologia e incluídos 36 diagnosticados por imuno-histoquímica (24 GIST e 12 outros sarcomas intestinais). Cães sem raça definida foram os mais diagnosticados com GIST, principalmente fêmeas idosas (9,5±2,2 anos); nos demais sarcomas intestinais, mestiços e Dachshunds, machos e fêmeas, foram igualmente acometidos. O ceco foi o mais acometido pelos GISTs, com invasão tumoral das camadas intestinais em todos os casos. O intestino delgado foi o mais acometido pelos demais sarcomas intestinais, com invasão das camadas na maioria desses tumores. GISTs expressaram marcadores como CD117 e DOG-1, ao contrário de outros sarcomas intestinais. O GIST e outros sarcomas intestinais denotaram características histomorfológicas e imunofenotípicas semelhantes à histopatologia, justificando a associação da imuno-histoquímica para o diagnóstico definitivo. (GIST cães objetivouse objetivou se idade 21 3 imunohistoquímica imuno histoquímica 24 (2 1 . intestinais) 9,5±2,2 9522 9 5 2 (9,5±2, anos anos) Dachshunds acometidos CD CD11 DOG1, DOG1 DOG 1, DOG-1 definitivo ( 9,5±2, 952 (9,5±2 CD1 DOG- 9,5±2 95 (9,5± 9,5± (9,5 9,5 (9, 9, (9

Abstract Polymersomes are nanometric vesicles that can encapsulate large and hydrophilic biomolecules, such as proteins, in the aqueous core. Data in literature show large variation in encapsulation efficiency (%EE) values depending on the method used for calculation. We investigated different approaches (direct and indirect) to quantify the %EE of different proteins (catalase, bovine serum albumin-BSA, L-asparaginase and lysozyme) in Pluronic L-121 polymersomes. Direct methods allow quantification of the actual payload of the polymersomes and indirect methods are based on the quantification of the remaining non-encapsulated protein. The protein-loaded polymersomes produced presented approximately 152 nm of diameter (PDI ~ 0.4). Higher %EE values were obtained with the indirect method (up to 25%), attributed to partial entanglement of free protein in the polymersomes poly(Ethylene Glycol) corona. For the direct methods, vesicles were disrupted with chloroform or proteins precipitated with solvents. Reasonable agreement was found between the two protocols, with values up to 8%, 6%, 17.6% and 0.9% for catalase, BSA, L-asparaginase and lysozyme, respectively. We believe direct determination is the best alternative to quantify the %EE and the combination of both protocols would make results more reliable. Finally, no clear correlation was observed between protein size and encapsulation efficiency. biomolecules core EE (%EE calculation catalase (catalase albuminBSA, albuminBSA albumin BSA albumin-BSA Lasparaginase L asparaginase lysozyme L121 121 L-12 nonencapsulated non encapsulated proteinloaded loaded 15 PDI 0.4. 04 0.4 . 0 4 0.4) 25%, 25 25% , 25%) polyEthylene poly Ethylene Glycol corona solvents 8 8% 6 6% 176 17 17.6 09 9 0.9 respectively reliable Finally L12 12 L-1 1 0. 2 17. L1 L-

RESUMEN Objetivo: identificar factores asociados al miedo al COVID-19 entre mujeres que vivieron el embarazo o el parto durante la pandemia. Métodos: estudio transversal, anidado dentro de una cohorte prospectiva, mediante encuesta en línea, de agosto de 2021 a febrero de 2022, basado en análisis de datos descriptivos. Resultados: de los 431 participantes, el 52,8% eran puérperas y el 20,1% eran gestantes. En cuanto al miedo al COVID-19 se obtuvo una puntuación media de 20,46 (miedo moderado). Las puntuaciones de miedo más altas estuvieron presentes en las mujeres cuyos recién nacidos fueron hospitalizados en unidades críticas neonatales (p=0,032), y las más bajas entre las cubiertas por el seguro complementario de salud (p=0,016). Conclusión: entre las mujeres embarazadas y puérperas, el alto temor a la COVID-19 se tradujo en la posibilidad de internar al recién nacido en una unidad de críticos. Se destaca la importancia de apoyar acciones para apoyar la salud mental de las mujeres embarazadas/en posparto en relación con el COVID-19 u otras amenazas que puedan influir en el resultado neonatal. Objetivo COVID19 COVID 19 COVID-1 pandemia Métodos transversal prospectiva línea 202 2022 descriptivos Resultados 43 participantes 528 52 8 52,8 201 20 1 20,1 gestantes 2046 46 20,4 moderado. moderado . moderado) p=0,032, p0032 p p=0,032 , 0 032 (p=0,032) p=0,016. p0016 p=0,016 016 (p=0,016) Conclusión críticos embarazadasen neonatal COVID1 COVID- 4 5 52, 2 20, 204 p003 p=0,03 03 (p=0,032 p001 p=0,01 01 (p=0,016 p00 p=0,0 (p=0,03 (p=0,01 p0 p=0, (p=0,0 p=0 (p=0, p= (p=0 (p= (p

ABSTRACT Objective: to identify factors associated with fear of COVID-19 among women who experienced pregnancy or childbirth during the pandemic. Methods: a cross-sectional study, nested within a prospective cohort, using an online survey, from August 2021 to February 2022, based on descriptive data analysis. Results: of the 431 participants, 52.8% were postpartum women and 20.1% were pregnant women. With regard to fear of COVID-19, a mean score of 20.46 was obtained (moderate fear). The highest fear scores were present in women whose newborns were admitted to hospital in neonatal critical units (p=0.032), and the lowest among those covered by supplementary health (insurance) (p=0.016). Conclusion: among pregnant and postpartum women, high fear of COVID-19 translated into the possibility of having newborns admitted to hospital in a critical unit. The importance of supporting actions to support pregnant/postpartum women’s mental health in relation to COVID-19 or other threats that may influence the neonatal outcome stands out. Objective COVID19 COVID 19 COVID-1 pandemic Methods crosssectional cross sectional study cohort survey 202 2022 analysis Results 43 participants 528 52 8 52.8 201 20 1 20.1 COVID19, 19, 2046 46 20.4 moderate fear. . fear) p=0.032, p0032 p p=0.032 , 0 032 (p=0.032) insurance (insurance p=0.016. p0016 p=0.016 016 (p=0.016) Conclusion unit pregnantpostpartum womens s out COVID1 COVID- 4 5 52. 2 20. 204 p003 p=0.03 03 (p=0.032 p001 p=0.01 01 (p=0.016 p00 p=0.0 (p=0.03 (p=0.01 p0 p=0. (p=0.0 p=0 (p=0. p= (p=0 (p= (p

RESUMO Objetivo: identificar fatores associados ao medo da COVID-19 entre mulheres que vivenciaram a gestação ou parto durante a pandemia. Métodos: estudo transversal aninhado à coorte prospectiva, por meio de inquérito online, no período de agosto de 2021 a fevereiro de 2022, a partir de análise descritiva dos dados. Resultados: dos 431 participantes, 52,8% eram puérperas e 20,1% gestantes. Com relação ao medo da COVID-19, obteve-se pontuação média de 20,46, (medo moderado). Os maiores escores de medo estiveram presentes em mulheres cujos recém-nascidos estavam internados em unidades críticas neonatais (p = 0,032) e os menores entre cobertos pela saúde suplementar (convênios) (p = 0,016). Conclusão: Entre gestantes e puérperas o alto medo da COVID-19 traduziu-se na possibilidade de ter o neonato internado em unidade crítica. Destaca-se a importância de subsidiar ações de suporte à saúde mental de gestantes/puérperas, com relação à COVID-19 ou outras ameaças, que possam influenciar o desfecho neonatal. Objetivo COVID19 COVID 19 COVID-1 pandemia Métodos prospectiva online 202 2022 dados Resultados 43 participantes 528 52 8 52,8 201 20 1 20,1 COVID19, 19, obtevese obteve se 2046 46 20,46 moderado. moderado . moderado) recémnascidos recém nascidos p 0,032 0032 0 032 convênios (convênios 0,016. 0016 0,016 016 0,016) Conclusão traduziuse traduziu crítica Destacase Destaca gestantespuérperas gestantes/puérperas ameaças neonatal COVID1 COVID- 4 5 52, 2 20, 204 20,4 0,03 003 03 001 0,01 01 0,0 00 0,

RESUMEN Objetivo: Informar los factores estructurantes de la experiencia de visitas domiciliarias de enfermeros a recién nacidos prematuros y de bajo peso. Método: Se trata de un estudio descriptivo de informe de experiencia, estructurado sobre la vivencia de las enfermeras autoras en el desarrollo de 48 visitas domiciliarias en una ciudad del interior de São Paulo y su microrregión, entre agosto de 2020 y 2021, entre ocho madres de recién nacidos prematuros y de bajo peso. Resultados: Se elaboraron y utilizaron los documentos orientadores “Visita domiciliaria para familias con RN Prematuro y de Peso Bajo al Nacer” y “Estrategia de preguntas guía para visita domiciliaria” con el fin de promover narraciones abiertas de los cuidadores parentales sobre el cuidado del recién nacido de riesgo, creando así, un espacio relacional con miras a la construcción conjunta. Conclusión: Los documentos utilizados favorecieron la realización de las visitas domiciliarias, ayudando al enfermero a establecer un vínculo profesional y a construir un espacio relacional a través del diálogo en la conducción de sus actividades en el entorno domiciliario. Objetivo peso Método 4 microrregión 202 2021 Resultados Visita Nacer Estrategia riesgo así conjunta Conclusión domiciliario 20 2

ABSTRACT Objective: To report the structures of the experience of nurse’s home visits to premature and low birth weight newborns. Method: This is a descriptive study of the experience report type, structured on the experience of the nurse authors in the development of 48 home visits in a city in the state of São Paulo and its microregion between August 2020 and 2021 with eight mothers of premature and low weight newborns. Results: The guiding documents “Home visit for families with preterm and low birth weight newborns” and “Strategy of guiding questions for home visits” were created and used to promote open narratives from parental caregivers about caring for at-risk newborns, creating a relational space aimed at joint construction. Conclusion: The documents used have favored home visits, helping nurses to establish professional bonds and build relational space through dialogue when conducting their activities in the home environment. Objective s newborns Method type 4 202 Results Home Strategy atrisk risk construction Conclusion environment 20 2

RESUMO Objetivo: Relatar os estruturantes da experiência de visitação domiciliar realizada por enfermeiros aos recém-nascidos prematuros e de baixo peso. Método: Trata-se de estudo descritivo do tipo relato de experiência, estruturado na vivência das enfermeiras autoras no desenvolvimento de 48 visitas domiciliares, em cidade do interior paulista e sua microrregião, entre agosto de 2020 e de 2021, com oito mães de recém-nascidos prematuros e de baixo peso. Resultados: Foram criados e utilizados os documentos orientadores “Visita domiciliar para famílias com RN Prematuro e de Baixo Peso ao Nascer” e “Estratégia de perguntas norteadoras para visita domiciliar” para promover narrativas abertas dos cuidadores parentais sobre o cuidado com o recém-nascido de risco, criando um espaço relacional direcionado à construção conjunta. Conclusão: Os documentos utilizados favoreceram a condução das visitas domiciliares, auxiliando o enfermeiro a estabelecer vínculo profissional e construir espaço relacional através do diálogo na condução de suas atividades em ambiente domiciliar. Objetivo recémnascidos recém nascidos peso Método Tratase Trata se 4 domiciliares microrregião 202 2021 Resultados Visita Nascer Estratégia recémnascido nascido risco conjunta Conclusão 20 2