Pesquisa | SciELO

ABSTRACT Purpose: To compare objective and subjective intraocular pressure measurements immediately after cataract surgery and intraocular pressure measurements between less experienced surgeons (Group 1) and experienced surgeons (Group 2). Methods: Surgeons were asked to estimate the IOP after corneal sealing after surgery based on their tactile perception of eye tension (subjective intraocular pressure) Objective intraocular pressure was measured using a Perkins tonometer while patients were still in the surgical field. Objective intraocular pressure was compared to subjective intraocular pressure. Results from less experienced surgeons were compared to more experienced surgeons. Results: The study comprised 81 surgeries (81 eyes) performed by 27 surgeons. The mean objective intraocular pressure (9.14 mmHg; SD=5.86) was statistically significantly lower (p<0.001) than the mean subjective intraocular pressure (19.21 mmHg; SD=4.82). Hypotony (intraocular pressure <6mmHg) was observed in 25 eyes (30.86%). The mean subjective intraocular pressure was 18.8 mmHg (SD=5.19) for less experienced surgeons and 19.5 mmHg (SD=4.46) for more experienced, without statistically significant difference (p=0.541). No statistically significant difference (p=0.71) was observed when comparing objective intraocular pressure in Group 1 (10.32 mmHg; SD=6.65) and Group 2 (7.97 mmHg; SD=4.7). Conclusion: Objective intraocular pressure was significantly lower than subjective intraocular pressure, regardless of surgeons’ experience. This study showed that the subjective method is unreliable compared to the gold standard (Perkins tonometer) and does not improve with surgeons’ experience. Establishing standard training methods is paramount to developing surgeons’ skills. Purpose 2. . 2) Methods field 8 (8 9.14 914 9 14 (9.1 SD=5.86 SD586 SD 5 86 p<0.001 p0001 p 0 001 (p<0.001 19.21 1921 19 21 (19.2 SD=4.82. SD482 SD=4.82 4 82 SD=4.82) <6mmHg 6mmHg 30.86%. 3086 30.86% 30 (30.86%) 188 18 18. SD=5.19 SD519 (SD=5.19 195 19. SD=4.46 SD446 46 (SD=4.46 p=0.541. p0541 p=0.541 541 (p=0.541) p=0.71 p071 71 (p=0.71 10.32 1032 10 32 (10.3 SD=6.65 SD665 6 65 7.97 797 7 97 (7.9 SD=4.7. SD47 SD=4.7 SD=4.7) Conclusion experience skills ( 9.1 91 (9. SD=5.8 SD58 p<0.00 p000 00 (p<0.00 19.2 192 (19. SD48 SD=4.8 308 30.86 3 (30.86% SD=5.1 SD51 (SD=5.1 SD=4.4 SD44 (SD=4.4 p054 p=0.54 54 (p=0.541 p=0.7 p07 (p=0.7 10.3 103 (10. SD=6.6 SD66 7.9 79 (7. SD4 SD=4. 9. (9 SD=5. SD5 p<0.0 p00 (p<0.0 (19 30.8 (30.86 (SD=5. (SD=4. p05 p=0.5 (p=0.54 p=0. p0 (p=0. 10. (10 SD=6. SD6 7. (7 SD=4 SD=5 p<0. (p<0. (1 30. (30.8 (SD=5 (SD=4 (p=0.5 p=0 (p=0 SD=6 SD= p<0 (p<0 (30. (SD= p= (p= p< (p< (30 (SD (p (3

https://doi.org/10.5935/0004-2749.2023-0174

Endometriose: pequenos avanços, grandes mudanças
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Reis, José

; Costa, Ana Rosa

; Silva, Daniel Pereira da

; Faustino, Fátima

; Águas, Fernanda

; Ferreira, Hélder

; Carvalho, Maria João

; Xavier, Pedro

Acta Obstétrica e Ginecológica Portuguesa

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Set 2024, Volume 18 Nº 3 Páginas 224 - 238

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Endometriosis is a chronic disease, characterized by the presence of endometrium outside the uterine cavity, which affects around 10% of women of reproductive age. Symptoms vary widely and can be absent or severe, debilitating and highly restrictive of quality of life. Pain, in different forms, intensities and associations, is the most striking symptom. The endometriosis is often associated with infertility and other comorbidities that represent additional risks for patients. Diagnosing is a major challenge. It is often delayed, for reasons rooted in the unspecific nosology of the disease, which is confused with common conditions. Another major challenge is treatment, since it is a chronic, multifaceted disease, sometimes with systemic repercussions, for which it is essential to find a personalized response. This review highlights the most recent aspects of pathogenesis and treatment options, particularly the new pharmacological options with GnRH antagonists, reserving surgery for specific situations. New molecular agents are being developed for the diagnosis and potential treatment of this disease. The configuration of clinical guidelines for optimizing the fertility potential of these patients remains to be defined.

Resumo A endometriose é uma doença crónica, caracterizada pela presença de endométrio fora da cavidade uterina, que afeta cerca de 10% das mulheres em idade reprodutiva. A sua expressão sintomática é muito variada, pode estar ausente ou ser grave, debilitante e altamente condicionante da qualidade de vida. A dor, com matizes e associações diversas, é o sintoma mais marcante. Associa-se com frequência a infertilidade e outras comorbilidades que representam riscos adicionais para as doentes. O diagnóstico da endometriose é um grande desafio. O atraso é frequente, por razões que radicam na nosologia pouco especifica da doença, que se confunde com situações comuns. Outro grande desafio é o tratamento, uma vez que é uma doença crónica, multifacetada, por vezes com repercussão sistémica, para a qual é indispensável encontrar uma resposta personalizada. Esta revisão destaca os aspetos mais recentes da patogénese e opções do tratamento, nomeadamente as novas opções farmacológicas com antagonistas da GnRH, reservando a cirurgia para situações específicas. Estão em desenvolvimento novos agentes moleculares para o diagnóstico e potencial tratamento desta doença. A configuração de orientações clínicas para a otimização do potencial de fertilidade dessas doentes continua por definir.

https://doi.org/10.69729/aogp.v18i3a07

Motivos de deserción en estudiantes de nutrición de una universidad pública
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Patiño Corona, Rosa Idzel

; Álvarez-Mancilla, Edgar Eduardo

; Vega Velazquez, Daniel Osmar

; AltamiranoMartínez, Martha Betzaida

; Cordero Muñoz, Aida Yanet

; Bernal Orozco, María Fernanda

; Rodríguez Rocha, Norma Patricia

; Macedo Ojeda, Gabriela

Academo (Asunción)

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Abr 2024, Volume 11 Nº 1 Páginas 17 - 28

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN El objetivo de este artículo es identificar la prevalencia de deserción en los alumnos de la Licenciatura en Nutrición (LN) de una universidad pública de México, las causas relacionadas con la deserción y agruparlas de acuerdo a sus características. Se realizó un estudio descriptivo en dos fases, en la fase 1 se identificaron los datos históricos de deserción del programa educativo. En la fase 2, se aplicó una encuesta de construcción propia con preguntas abiertas y cerradas, de la cual se obtuvo la respuesta de 75 estudiantes desertores. La encuesta incluyó un análisis dicotómico (sí, no) de 18 factores asociados a la deserción escolar, totalizando 22 al incorporar los aspectos cualitativos obtenidos de la opción de respuesta "otros"; estos factores se agruparon en seis categorías. Se encontró una tasa de deserción escolar del 18% para el plan de estudios actual y el intermedio y hasta el 33% en el primer plan de estudios. De los desertores detectados, el 58.6% lo hizo en el primer año de estudios. El 66% de los desertores reprobaron al menos una unidad de aprendizaje y tienen una calificación promedio de 72.71, por debajo de la media general de la LN del centro universitario (91.8). De los desertores, el 49.3% identificó el cambio de carrera como su motivo de abandono, este factor forma parte de la categoría de "causas vocacionales" que ocupó el primer lugar con el 72%, seguido de "aspectos personales" con el 49.3% incluyendo 3 casos de maternidad; y en tercer lugar la categoría de "aspectos económicos" (26.7%). El principal motivo de deserción de los alumnos de la LN son los aspectos vocacionales relacionados con la búsqueda de otra carrera.

ABSTRACT The objective of this article is to identify the prevalence of dropout in students from the bachelor's degree in nutrition (LN) at a public university in Mexico, the causes related to dropout, and group them according to their characteristics. A descriptive study was carried out in two phases; in phase 1, the historical data on attrition from the educational program were identified. In phase 2, we applied a self-constructed survey with open and closed questions and obtained a response from 75 dropout students. The survey included a dichotomous analysis (yes, no) of 18 factors associated with school dropout, totaling 22 when incorporating the qualitative aspects obtained from the "other" response option; these factors were grouped into six categories. A dropout rate of 18 % was found for the current and intermediate curriculum and up to 33 % in the first curriculum. Of the dropouts detected, 58.6 % came to pass in the first year of studies. The 66 % of the dropouts have failed at least one subject; their average grade is 72.71, below the general average from the LN of the university center (91.8). Of the dropouts, 49.3 % identified career change as their reason for dropping out, which is part of the category of "vocational causes" that ranked first with 72 %, followed by "personal aspects" with 49.3 % including 3 cases of maternity; and in third place the category of "economic aspects" (26.7 %). The main reason for dropout among LN students is vocational aspects related to the search for another career.

https://doi.org/10.30545/academo.2024.ene-abr.3

Spontaneous orbitofacial neurofibroma in a sow
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Echenique, Joanna Vargas Zillig

; Perosa, Fernanda Felicetti

; Suzin, Giuliano Orlandi

; Piva, Manoela Marchezan

; Rosa, Rafael Biondo

; Bandinelli, Marcele Bettim

; Pavarini, Saulo Petinatti

Ciência Rural

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2024, Volume 54 Nº 2 elocation e20230078

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Neurofibromas são neoplasias derivadas dos feixes nervosos e são frequentes em humanos, mas incomuns em espécies animais domésticos. Esse relato tem como objetivo descrever os achados macroscópicos, histológicos e imuno-histoquímicos de um neurofibroma orbitofacial em uma matriz suína. O animal apresentava as pálpebras esquerdas acentuadamente expandidas, associada a severo ectrópio e avermelhamento de ambas as mucosas conjuntivais. A tumoração palpebral, na superfície de corte, era homogênea, levemente acastanhada e brilhante, medindo 9,0 x 7,0 x 7,0 cm, e comprimia o globo ocular. Microscopicamente foi observada uma proliferação neoplásica pobremente celular de células alongadas no meio de uma acentuada quantidade de matriz mixoide. Havia áreas intratumorias multifocais onde fascículos nervosos bem diferenciados e musculatura esquelética foram observados. As células neoplásicas foram positivas na imuno-histoquímica para GFAP, neurofilamento, S-100, Sox-10 e vimentina. Citoqueratina mostrou uma imunomarcação ao redor de feixes nervosos primitivos e desmina ao redor de vasos neoformados e feixes musculares dentro do tumor. O neurofibroma orbitofacial, apesar de comum em humanos, nunca foi descrito em suínos domésticos e deve ser considerado um diagnóstico diferencial para neoplasias palpebrais em suínos. RESUMO humanos macroscópicos imunohistoquímicos imuno histoquímicos suína expandidas conjuntivais palpebral corte homogênea brilhante 90 9 0 9, 70 7 7, cm ocular mixoide observados imunohistoquímica histoquímica GFAP neurofilamento S100, S100 S 100, 100 S-100 Sox10 Sox 10 Sox-1 vimentina tumor S10 S-10 Sox1 1 Sox- S1 S-1 S-

ABSTRACT: Neurofibromas are neoplasms derived from nerve bundles and are frequent in humans but not common in animals. This report described the macroscopic, histologic, and immunohistochemistry findings of an orbitofacial neurofibroma in a sow. The sow presented left eyelids with marked expansion, associated with severe ectropion and reddening of both conjunctival mucosae. The mass on the cutting surface was homogeneous, with a light tan, and shiny, measuring 9.0 x 7.0 x 7.0 cm in width, compressing the eyeball. Microscopically, there was paucicellular neoplastic proliferation of elongated cells amid the accentuated myxoid matrix. There were multifocal areas where well-differentiated nervous fascicles and skeletal musculature were seen. Neoplastic cells were immunostained positive for GFAP, neurofilament, S-100, Sox-10, and vimentin. Cytokeratin showed immunolabeling around primitive nerve bundles and desmin around neoformed vessels and muscle bundles within the tumor. Orbitopalpebral and orbitofacial neurofibroma, despite being common in humans, have not been described in domestic pigs and should be considered as a differential diagnosis in eyelid tumors in pigs. ABSTRACT animals macroscopic histologic expansion mucosae homogeneous tan shiny 90 9 0 9. 70 7 7. width eyeball Microscopically matrix welldifferentiated well differentiated seen GFAP neurofilament S100, S100 S 100, 100 S-100 Sox10, Sox10 Sox 10, 10 Sox-10 vimentin tumor S10 S-10 Sox1 1 Sox-1 S1 S-1 Sox- S-

https://doi.org/10.1590/0103-8478cr20230078

Régimen jurídico de la demolición
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Gómez-González, Rosa Fernanda

Revista de derecho (Valdivia)

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2024, Volume 37 Nº 1 Páginas 145 - 167

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN: Esta investigación analiza el régimen jurídico de la demolición como institución urbanística. Se sostiene que la arquitectura normativa de la demolición es consistente con los objetivos que en cada caso persigue, no obstante, se trata de un marco jurídico que debe ser analizado con detenimiento, especialmente en aquellos casos en los que se dispone como medida de restablecimiento de la legalidad y de prevención, porque se duplican competencias y se entregan amplios márgenes de discrecionalidad a la autoridad que la ejerce, lo que puede devenir en un ejercicio arbitrario o desproporcionado de la institución.

ABSTRACT: This research analyzes the legal regime of demolition as an urban planning institution. It is maintained that the regulatory architecture of demolition is consistent with the objectives pursued in each case; however, it is a legal framework that must be carefully analyzed, especially in those cases in which it is available as a measure to reestablish legality and prevention, since powers are duplicated and wide margins of discretion are given to the authority that exercises it, which can result in an arbitrary and/or disproportionate exercise of the institution.

https://doi.org/10.4067/s0718-09502024000100145

Optimization of Hydrolysis and Identifcation of Bioactive Peptides in Brewery Yeast Residuals
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Rosa, Fernanda A. Della

; Tonin, Angelica P.

; Rocha, Beatriz S.

; Santos, Marco A. R.

; Silveira, Fabiane M.

; Cardoso-Filho, Lucio

; Ribeiro, Valquíria M. S.

; Meurer, Eduardo C.

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 3 elocation e-20230146

Resumo: En | Texto: En | PDF: En

Industrial waste products are of biotechnological interest due to their abundance and can be utilized as protein sources for the production of bioactive peptides through hydrolysis. The utilization of yeast residues from the brewing industry has been demonstrated to be a viable method for obtaining protein hydrolysates. The degree of hydrolysis and soluble total protein of the hydrolysates were evaluated for optimization purposes to achieve a product with a high proportion of soluble organic nitrogen, increased levels of bioactive peptides and amino acids. Both alkaline and enzymatic hydrolysis processes were tested. The hydrolyses were carried out with the aim of large-scale implementation. The treatments were effective in liberating intracellular content and producing biologically functional hydrolysates, with degree of hydrolysis values ranging from 28 to 63% and total protein from 2.95 to 8.28% at the optimum points confrmed by statistical analysis (analysis of variance (ANOVA)). The hydrolysate produced with Alcalase® exhibited the highest peptide intensity, while the hydrolysate produced with Flavourzyme® showed the highest concentration of free amino acids. The peptides were identifed by mass spectrometry and were found to have biological activities according to the Biopep database. This study presents a quick and economically feasible approach for the implementation of a pilot project for the reuse of this waste. nitrogen acids tested largescale large scale 2 63 295 95 2.9 828 8 8.28 ANOVA. ANOVA . (ANOVA)) Alcalase intensity Flavourzyme database 6 29 9 2. 82 8.2 (ANOVA) 8. (ANOVA

https://doi.org/10.21577/0103-5053.20230146

Hepatitis A vaccination coverage survey in 24-month-old children living in Brazilian capitals, 2020
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Moura, Winny Éveny Alves

; Caetano, Karlla Antonieta Amorim

; Lima, Juliana de Oliveira Roque e

; Campos, Lays Rosa

; Silva, Grazielle Rosa da Costa e

; Moraes, José Cássio de

; França, Ana Paula

; Domingues, Carla Magda Allan Santos

; Teixeira, Maria da Gloria Lima Cruz

; Teles, Sheila Araújo

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231162

Resumo: Pt Es En | Texto: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Estimar a cobertura vacinal da hepatite A em crianças de 24 meses e identificar fatores associados à ausência de vacinação. Métodos Inquérito em amostra estratificada por estratos socioeconômicos em capitais (2020-2022), com estimativa de cobertura e intervalos de confiança de 95% (IC95%) e análise de fatores pela razão de prevalência (RP) via regressão de Poisson. Resultados Nas 31.001 crianças, a cobertura da hepatite A foi de 88,1% (IC95% 86,8;89,2). Nos estratos socioeconômicos (A/B), a variável pais/responsáveis imigrantes foi associada à ausência de vacinação (RP = 1,91; IC95% 1,09;3,37); nos estratos C/D, crianças de cor amarela (RP = 4,69; IC95% 2,30;9,57), 4ª ordem de nascimento ou mais (RP = 1,68; IC95% 1,06;2,66), não frequentar creche/berçário (RP = 1,67; IC95% 1,24;2,24) e mãe com trabalho remunerado (RP = 1,42; IC95% 1,16;1,74) foram associadas à ausência de vacinação. Conclusão Cobertura da hepatite A abaixo da meta (95%), sugerindo-se considerar especificidades dos estratos sociais.

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ABSTRACT Objective To estimate hepatitis A vaccination coverage in 24-month-old children and identify factors associated with non-vaccination. Methods This was a survey involving a sample stratified by socioeconomic strata in capital cities (2020-2022), with coverage estimates and 95% confidence intervals (95%CI), the factor analysis was performed using the prevalence ratio (PR) by means of Poisson regression. Results Among 31,001 children, hepatitis A coverage was 88.1% (95%CI 86.8;89.2). Regarding socioeconomic strata (A/B), the variable immigrant parents/guardians was associated with non-vaccination (PR = 1.91; 95%CI 1.09;3.37); in strata C/D, children of Asian race/skin color (PR = 4.69; 95%CI 2.30;9.57), fourth-born child or later (PR = 1.68; 95%CI 1.06;2 .66), not attending daycare/nursery (PR = 1.67; 95%CI 1.24;2.24) and mother with paid work (PR = 1.42; 95%CI 1.16;1.74) were associated with non-vaccination. Conclusion Hepatitis A coverage was below the target (95%), suggesting that specificities of social strata should be taken into consideration.

https://doi.org/10.1590/s2237-96222024v33e20231162.en

Detection of antibodies against Leishmania species using enzyme-linked immunosorbent assay in cats from the western border of Brazil enzymelinked enzyme linked
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Pradella, Gabriela Döwich

; Escobar, Taiane Acunha

; Santos, Thália Pacheco dos

; Minuzzi, Jennifer Stello

; Silva, Lívia Kmetzsch Rosa e

; Roman, Isac Junior

; Vogel, Fernanda Silveira Flôres

; Duarte, Claudia Acosta

; Lübeck, Irina

Ciência Rural

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2024, Volume 54 Nº 8 elocation e20230127

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: A leishmaniose felina é relatada esporadicamente em todo o mundo e, a espécie foi sugerida como um reservatório secundário para o parasita. Apesar disso, há carência de técnicas diagnósticas específicas para amostras de felinos. O presente estudo teve como objetivo padronizar um Ensaio de Imunoabsorção Enzimática (ELISA) indireto interno, utilizando o antígeno cru de L. infantum para detectar anticorpos em amostras felinas em uma área endêmica de CVL na fronteira oeste do Brasil e, comparar os resultados com o ensaio de imunofluorescência indireta (IFA). Foram testados felinos residentes em Uruguaiana e Barra do Quaraí - RS, semi-domiciliados. Entre as 41 amostras testadas, 25 (61%) foram positivas no ELISA e 24 (58%) no IFA (1:40). O presente estudo elucidou uma alta soropositividade de amostras felinas em uma área endêmica de leishmaniose visceral canina na fronteira Oeste do Brasil e demonstrou a possibilidade de aplicar um ELISA com antígeno bruto para diagnóstico de triagem populacional. Além disso, este é o primeiro inquérito sorológico em felinos na região onde a leishmaniose visceral canina está bem estabelecida. RESUMO parasita disso (ELISA interno L IFA. . (IFA) RS semidomiciliados. semidomiciliados semi domiciliados. domiciliados semi-domiciliados 4 testadas 2 61% 61 (61% 58% 58 (58% 140. 140 1 40 (1:40) populacional estabelecida (IFA 6 (61 5 (58 14 (1:40 (6 (5 (1:4 ( (1: (1

ABSTRACT: Feline leishmaniosis is infrequent worldwide, and cats have been suggested as secondary reservoirs for the parasite. However, specific diagnostic techniques for feline samples are scarce. In this study, we standardized an in-house indirect enzyme-linked immunosorbent assay (ELISA) using crude Leishmaniainfantum antigen to detect antibodies in feline samples from an endemic canine visceral leishmaniosis (CVL) area in the western border of Brazil. The results were compared with those of an indirect immunofluorescence assay (IFA). We tested semi-domiciled felines residing in Uruguaiana and Barra do Quaraí, Rio Grande do Sul. Among the 41 samples, 25 (61%) were positive using ELISA and 24 (58%) were positive using IFA (1:40). Our findings demonstrated a high seropositivity of feline samples from the endemic CVL area in the western border of Brazil, and we proposed the use of an in-house ELISA with crude antigen for population screening. This is the first serological survey on felines in a region where CVL is well established. ABSTRACT worldwide parasite However scarce study inhouse house enzymelinked enzyme linked (ELISA (CVL Brazil IFA. . (IFA) semidomiciled semi domiciled Quaraí Sul 4 2 61% 61 (61% 58% 58 (58% 140. 140 1 40 (1:40) screening established (IFA 6 (61 5 (58 14 (1:40 (6 (5 (1:4 ( (1: (1

https://doi.org/10.1590/0103-8478cr20230127

Influence of repositioning guides’ color and usage on precision in tooth color measurement with a clinical spectrophotometer guides
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SANTANA, Tauan Rosa

; SILVA, Paula Fernanda Damasceno

; SANTANA, Márcia Luciana Carregosa

; MATTOS, Clara Lemos Leal Barata de

; FARIA-E-SILVA, André Luis

Journal of Applied Oral Science

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2024, Volume 32 elocation e20230348

Resumo: En | Texto: En | PDF: En

Abstract Repositioning guides are commonly employed in clinical studies to ensure consistent tooth color measurements. Yet, their influence on measured color remains uncertain. Objective This study evaluated the impact of repositioning guides’ color and usage on tooth color measurement using a clinical spectrophotometer. Methodology In total, 18 volunteers participated in this study, in which the color of their upper left central incisor and upper left canine was measured with or without repositioning guides (control). The guides were made from pink, blue, or translucent silicone, as well as an acetate-based bleaching tray. Tooth color was measured in triplicates using a clinical spectrophotometer based on the CIELAB system. The standard deviations of these readings were used to estimate reproducibility, and color differences (ΔE00) between the measurements with guides and the control were calculated. Results Repositioning guides had a minimal effect on L* values and no effect on b* values. The use of pink silicone increased a* values, whereas blue or translucent silicone reduced them. Irrespective of the evaluated tooth, the lowest ΔE00 values were observed for the translucent silicone and bleaching tray. The usage of guides only affected data variability for the L* color coordinate. Conclusion Using repositioning guides can significantly impact the precision of tooth color measurement with a clinical spectrophotometer. Yet uncertain total 1 control. . (control) acetatebased acetate tray system reproducibility ΔE (ΔE00 calculated L b them ΔE0 coordinate (control (ΔE0 (ΔE

https://doi.org/10.1590/1678-7757-2023-0348

10.

Color matching and color recovery in large composite restorations using single-shade or universal composites singleshade single shade
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Rosa, Ellen Dionélia Alencar Rodrigues

; Silva, Larissa Fernandes Vieira Da

; Silva, Paula Fernanda Damasceno

; Silva, André Luís Faria e

Brazilian Dental Journal

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2024, Volume 35 elocation e24-5665

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo avaliou a habilidade de combinação de cores e recuperação de cor de dentes não preparados ao utilizar resinas compostas de única tonalidade e uma resina composta universal em grandes restaurações. As cores das superfícies bucais e palatinas de molares foram medidas com um espectrofotômetro (CIELAB) antes de preparar cavidades esféricas (6 mm de diâmetro, 2 mm de profundidade). As cavidades foram preenchidas aleatoriamente com uma resina composta de única tonalidade (Omnichroma, Diamond One ou Vittra APS Unique) ou com uma resina composta universal (Filtek Universal). Foram realizadas medições das cores das cavidades restauradas e calculadas as diferenças de cor globais (ΔEab and ΔE00)) e as diferenças no índice de clareamento para odontologia (ΔWID) em relação à cor inicial. Além disso, foram realizadas avaliações visuais da correspondência de cor com o esmalte circundante por quarenta avaliadores (leigos e estudantes de odontologia) em uma cabine de visualização sob iluminante D65, com pontuações de 0 (nenhuma discrepância de cor) a 4 (não aceitável). Os dados foram analisados usando RM ou ANOVA unidirecional (α = 0,05). Os resultados mostraram que as restaurações geralmente apresentavam cores mais brancas (WID variou de 27,9 a 41,3) do que os dentes não preparados (WID variou de 15,9 a 19,3). A resina composta Filtek Universal demonstrou a menor discrepância de cor (ΔWID = 8,6; ΔE00 = 10,8; and ΔE00 = 6,2), e não foram observadas diferenças significativas entre as resinas compostas de única tonalidade avaliadas. Além disso, todas as resinas compostas apresentaram correspondência de cor similar e adequada com o esmalte circundante. No entanto, é importante observar que, apesar de sua capacidade de corresponder razoavelmente com o esmalte circundante, nenhuma das resinas compostas avaliadas em grandes restaurações recuperou completamente a cor observada nos dentes não preparados. CIELAB (CIELAB 6 ( diâmetro profundidade. profundidade . profundidade) Omnichroma, Omnichroma (Omnichroma Unique Universal. Universal) ΔEab ΔE ΔE00) ΔWID inicial disso leigos D65 D aceitável. aceitável aceitável) α 0,05. 005 0,05 05 0,05) WID 279 27 9 27, 41,3 413 41 3 159 15 15, 19,3. 193 19,3 19 19,3) 8,6 86 8 ΔE0 10,8 108 10 6,2, 62 6,2 , 6,2) entanto D6 00 0,0 41, 1 19, 8, 10, 6, 0,

Abstract This study assessed the color-matching ability and color recovery of unprepared teeth when using single-shade composites and a universal composite in large restorations. Buccal and palatine surface colors of molars were measured with a spectrophotometer (CIELAB) before preparing round cavities (6 mm in diameter, 2 mm in depth). The cavities were randomly filled with a single-shade composite (Omnichroma, Diamond One, or Vittra APS Unique) or a universal composite (Filtek Universal). Color measurements of the restored cavities were taken, and overall color differences (ΔEab and ΔE00) and differences in the whitening index for dentistry (ΔWID) from baseline were calculated. Additionally, visual assessments of a color match to the surrounding enamel were performed by forty evaluators (laypersons and undergraduate students of dentistry) in a viewing booth under illuminant D65, with rating scores from 0 (no color mismatch) to 4 (not acceptable). Data were analyzed using RM or one-way ANOVA (α = 0.05). Results showed that the restorations generally exhibited whiter colors (WID ranged from 27.9 to 41.3) than the unprepared teeth (WID ranged from 15.9 to 19.3). The composite Filtek Universal demonstrated the lowest color discrepancy (ΔWID = 8.6; ΔE00 = 10.8; and ΔE00 = 6.2), and no significant differences were observed among the evaluated single-shade composites. Furthermore, all composites showed similar and adequate color matches to the surrounding enamel. However, it is important to note that despite their ability to match the surrounding enamel reasonably, none of the composites evaluated in large restorations fully recovered the color observed in unprepared teeth. colormatching matching singleshade single shade CIELAB (CIELAB 6 ( diameter depth. depth . depth) Omnichroma, Omnichroma (Omnichroma One Unique Universal. Universal) taken ΔEab ΔE ΔWID calculated Additionally laypersons D65 D mismatch not acceptable. acceptable acceptable) oneway one way α 0.05. 005 0.05 05 0.05) WID 279 27 9 27. 41.3 413 41 3 159 15 15. 19.3. 193 19.3 19 19.3) 8.6 86 8 ΔE0 10.8 108 10 6.2, 62 6.2 , 6.2) Furthermore However reasonably D6 00 0.0 41. 1 19. 8. 10. 6. 0.

https://doi.org/10.1590/0103-6440202405665

11.

Mycotoxin concentration in salt-treated wet brewers’ grains and effects of their substitution for soybean meal and corn silage salttreated salt treated brewers
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Silva, Anderson Moura da

; Hentz, Fernanda

; Dornelles, Renata da Rosa

; Martini, Maria Isabel

; Silva, Larissa Henrique da

; Ribeiro-Filho, Henrique Mendonça Nunes

Revista Brasileira de Zootecnia

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2024, Volume 53 elocation e20240013

Resumo: En | Texto: En | PDF: En

ABSTRACT This study investigated the occurrence of mycotoxins in wet brewers’ grains (WBG) treated with salt (sodium chloride) and the intake, nutrient digestibility, and nitrogen use efficiency in lamb diets. Two experiments were conducted: first, WBG was distributed in plastic boxes and treated with no additive (control), sodium formate (3 g/kg of WBG), or three levels of salt—25, 30, and 35 g/kg of WBG. The WBG were stored at room temperature (17.7±4.6 ℃) for 27 days. In the second experiment, eight six-month-old male lambs were allotted to one of four total mixed ration (TMR) diets in a 4 × 4 double Latin square: 0, 10, 20, and 30% of WBG replacing corn silage and soybean meal. In the first experiment, the concentration of mycotoxins throughout the experiment was lower than the tolerance levels accepted by the European Community and Food and Drug Administration for animal feedstuffs. However, the control and sodium formate groups showed visual fungal development on the WBG surface from the sixth day and presented an unpleasant smell from day 12. In the salt treatments, fungal growth was observed on top of the WBG from day 12 and an unpleasant smell from day 15. Salt-treated WBG showed a lower pH than the control and sodium formate groups and decreased dry matter deterioration. In the second experiment, including up to 30% WBG in the TMR did not affect dry matter, organic matter, neutral detergent fiber, and acid detergent fiber intake or digestibility in lambs. However, the N digestibility and N use efficiency increased with WBG inclusion. These results suggest that salt can be used to increase the storage time of WBG up to 15 days and the inclusion of up to 30% WBG in TMR for lambs can improve N use efficiency without negatively affecting nutrient intake and digestibility. brewers (WBG chloride conducted control, , (control) 3 ( gkg g kg WBG, WBG) salt25, salt25 25, 25 salt—25 30 17.7±4.6 17746 17 7 6 (17.7±4. ℃ 2 sixmonthold six month old (TMR square 0 10 20 meal feedstuffs However treatments 1 Salttreated Salt deterioration (control salt2 salt—2 17.7±4. 1774 (17.7±4 salt— 17.7±4 177 (17.7± 17.7± (17.7 17.7 (17. 17. (17 (1

https://doi.org/10.37496/rbz5320240013

12.

IDENTIFICAÇÃO DE BARREIRAS DE SEGURANÇA NO PREPARO E ADMINISTRAÇÃO DE MEDICAMENTOS POR PROFISSIONAIS DE ENFERMAGEM
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Cogo, Ana Luísa Petersen

; Perdomini, Fernanda Rosa Indriunas

; Flores, Giovana Ely

; Severo, Isis Marques

; Brahm, Marise Márcia These

; Dias, Mirella de Oliveira Tatsch

Cogitare Enfermagem

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2024, Volume 29 elocation e94904

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: Objetivo: descrever o padrão de conformidade profissional em relação ao conhecimento sobre as barreiras de segurança no preparo e administração dos medicamentos. Método: estudo descritivo, quantitativo, retrospectivo, realizado entre janeiro e dezembro de 2021, em hospital do Sul do Brasil, com profissionais de enfermagem. Implementou-se o Exame Clínico Objetivo Estruturado em estação clínica simulada, por aplicação de checklist contemplando barreiras de segurança. Realizou-se análise descritiva em números absolutos e percentual. Resultados: participaram 1.682 profissionais. As barreiras sinalizadas foram: prescrição médica eletrônica (86,1%), pulseira de identificação do paciente (80,3%), etiquetas de medicamentos preenchidas previamente ao preparo (74,5%) e tabela de diluição de medicamentos (63,9%). O padrão de conformidade em relação ao conhecimento sobre as barreiras apresentou-se em 73,8% dos profissionais como conforme; em 19% deles como parcial conforme e em 7,1% como não conforme. Conclusão: a conformidade em relação às barreiras de segurança identificadas, demonstrou o conhecimento dos profissionais na assistência. RESUMO Método descritivo quantitativo retrospectivo 2021 Brasil enfermagem Implementouse Implementou se simulada Realizouse Realizou percentual Resultados 1682 1 682 1.68 foram 86,1%, 861 86,1% , 86 (86,1%) 80,3%, 803 80,3% 80 3 (80,3%) 74,5% 745 74 5 (74,5% 63,9%. 639 63,9% . 63 9 (63,9%) apresentouse apresentou 738 73 8 73,8 19 71 7 7,1 Conclusão identificadas assistência 202 168 68 1.6 86,1 (86,1% 80,3 (80,3% 74,5 (74,5 63,9 6 (63,9% 73, 7, 20 16 1. 86, (86,1 80, (80,3 74, (74, 63, (63,9 2 (86, (80, (74 (63, (86 (80 (7 (63 (8 ( (6

ABSTRACT Objective: to describe the professional compliance standards regarding knowledge of safety barriers in the preparation and administration of medications. Method: a descriptive, quantitative, retrospective study conducted between January and December 2021 in a hospital in Southern Brazil, involving nursing professionals. The Objective Structured Clinical Examination was implemented in a simulated clinical station using a checklist that included safety barriers. Descriptive analysis was performed using absolute numbers and percentages. Results: a total of 1,682 professionals participated. The safety barriers identified were: electronic medical prescription (86.1%), patient identification wristband (80.3%), pre-filled medication labels before preparation (74.5%), and medication dilution chart (63.9%). Compliance with knowledge of safety barriers was found to be in full compliance for 73.8% of professionals, partially compliant for 19%, and non-compliant for 7.1%. Conclusion: compliance with identified safety barriers demonstrated the professionals’ knowledge in care provision. medications Method descriptive quantitative 202 Brazil percentages Results 1682 1 682 1,68 participated were 86.1%, 861 86.1% , 86 (86.1%) 80.3%, 803 80.3% 80 3 (80.3%) prefilled pre filled 74.5%, 745 74.5% 74 5 (74.5%) 63.9%. 639 63.9% . 63 9 (63.9%) 738 73 8 73.8 19 19% noncompliant non 71 7 7.1% Conclusion provision 20 168 68 1,6 86.1 (86.1% 80.3 (80.3% 74.5 (74.5% 63.9 6 (63.9% 73. 7.1 2 16 1, 86. (86.1 80. (80.3 74. (74.5 63. (63.9 7. (86. (80. (74. (63. (86 (80 (74 (63 (8 (7 (6 (

RESUMEN Objetivo: describir el estándar de conformidad profesional sobre el conocimiento de las barreras de seguridad en la preparación y administración de medicamentos. Método: estudio descriptivo, cuantitativo, retrospectivo, realizado entre enero y diciembre de 2021, en un hospital del sur de Brasil, con profesionales de enfermería. El Examen Clínico Objetivo Estructurado se implementó en una estación clínica simulada, mediante la aplicación de una checklist que incluye barreras de seguridad. Se realizó un análisis descriptivo en números absolutos y porcentajes. Resultados: Participaron 1.682 profesionales. Las barreras mencionadas fueron: receta médica electrónica (86,1%), pulsera de identificación del paciente (80,3%), etiquetas de medicamentos completadas antes de la preparación (74,5%) y tabla de dilución de medicamentos (63,9%). El 73,8% de los profesionales obtuvo conforme en el estándar de conformidad sobre el conocimiento de las barreras; el 19% de ellos parcialmente conforme y el 7,1% no conforme. Conclusión: la conformidad de las barreras de seguridad identificadas demostró el conocimiento de los profesionales en la atención. Método cuantitativo retrospectivo 2021 Brasil enfermería simulada porcentajes Resultados 1682 1 682 1.68 fueron 86,1%, 861 86,1% , 86 (86,1%) 80,3%, 803 80,3% 80 3 (80,3%) 74,5% 745 74 5 (74,5% 63,9%. 639 63,9% . 63 9 (63,9%) 738 73 8 73,8 19 71 7 7,1 Conclusión atención 202 168 68 1.6 86,1 (86,1% 80,3 (80,3% 74,5 (74,5 63,9 6 (63,9% 73, 7, 20 16 1. 86, (86,1 80, (80,3 74, (74, 63, (63,9 2 (86, (80, (74 (63, (86 (80 (7 (63 (8 ( (6

https://doi.org/10.1590/ce.v29i0.94904

13.

Molecular test for screening malaria-infected blood donors to maximise recipient safety in Acre State, a Brazilian endemic area malariainfected malaria infected State
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Pinheiro, Thereza Cristina Picado

; Santos, Sabrina Silva

; Simião, Fernanda Moura El Bayet

; Mello, Aline Rosa de Lavigne

; Pimentel, Cinara de Barros

; Lomonaco, Leonardo Assad

; Alvarez, Patrícia

; Daniel-Ribeiro, Cláudio Tadeu

; Koifman, Rosalina Jorge

; Ferreira-da-Cruz, Maria de Fátima

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e240109

Resumo: En | Texto: En | PDF: En

BACKGROUND Although blood transfusion is an essential therapeutic procedure, it can present risks, including transmitting infectious diseases, such as malaria. In Acre, the thick blood smear microscopic examination (TBS) is used to screen infected malaria blood donors. However, TBS has low sensitivity for detecting Plasmodium in situations of low parasitaemia, such as those presented by asymptomatic clinically healthy individuals. OBJECTIVES To investigate the pertinence of using polymerase chain reaction (PCR) to detect malarial infection for screening blood donors in Cruzeiro do Sul, Acre, an endemic high-risk malaria area in the Legal Amazon. METHODS A cross-sectional study was conducted among individuals eligible and ineligible to be blood donors, according to clinical and epidemiological criteria. Besides the mandatory screening of HCV, HBV, and HIV tests, malaria PCR and TBS were also carried out on all blood donor candidates who attended the Cruzeiro do Sul Blood Centre from July to September 2022. FINDINGS Of the 230 participants, 209 (91%) were eligible for blood donation by clinical-epidemiological screening. Surprisingly, no blood donor candidate reported a history of malaria. All TBS microscopic tests were negative at the time of recruitment. However, samples from four blood donor candidates (two eligible by clinical and epidemiological malaria criteria and two ineligible by hypertension and recent tattoo) were positive by Plasmodium and P. vivax molecular tests. MAIN CONCLUSIONS Malaria molecular techniques for screening blood donors should be introduced in the Brazilian Blood Centres to maximise recipient safety. Furthermore, selecting zero-risk donors could pave the way to build a transmissible malaria-free environment in the blood bank context in the near future. procedure risks diseases Acre (TBS However parasitaemia (PCR highrisk high risk Amazon crosssectional cross sectional HCV HBV 2022 23 participants 20 91% 91 (91% clinicalepidemiological Surprisingly recruitment tattoo P safety Furthermore zerorisk zero malariafree free future 202 2 9 (91 (9 (

https://doi.org/10.1590/0074-02760240109

14.

Pomegranate oil-based nanocapsules enhance 3,3’-diindolylmethane action against melanoma cells oilbased oil based 3,3diindolylmethane 33diindolylmethane diindolylmethane 3,3 3 3diindolylmethane 33 3,
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Reolon, Jéssica Brandão

; Merg, Carina Dinah

; Oliveira, Daiane Britto de

; Cabral, Fernanda Licker

; Osmari, Bárbara Felin

; Sari, Marcel Henrique Marcondes

; Brucker, Natália

; Leal, Daniela Bitencourt Rosa

; Cruz, Letícia

Brazilian Journal of Pharmaceutical Sciences

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2024, Volume 60 elocation e23931

Resumo: En | Texto: En | PDF: En

Abstract Cutaneous melanoma, a highly aggressive skin cancer, is the leading cause of death among skin neoplasms. Hence, this study focused on developing a 3,3'-diindolylmethane (DIM)-loaded pomegranate oil (PO) nanocapsule suspensions and their potential effects on melanoma cells. Nanocapsule suspensions were prepared by the interfacial deposition method (Eudragit ® RS100). Medium-chain triglyceride (MCT) nanocapsules were produced for comparison. The of nanocapsule suspensions showed nanometric size (<180 nm), low polydispersity index (<0.12) (as measured by dynamic light scattering), positive zeta potential (tested by capillary microelectrophoresis), pH below 5.0 (as measured by potentiometry), DIM content, and nearly 100% encapsulation efficiency (evaluated by HPLC). The formulations were considered non-irritating (according to HET-CAM) regardless of the core constitution. Notably, PO-based nanocapsules showed a superior performance compared to the MCT-containing formulation in delaying DIM light degradation (tested by UVC radiation), lowering genotoxicity (determined by Allium cepa ), and increasing in vitro antioxidant action (measured by ABTS and FRAP). Additionally, the PO-based formulation demonstrated higher in vitro antitumoral activity in B16F10 than MCT nanocarriers (IC 50 of 6.49 and >24 µg/mL, respectively), and antimetastatic capacity by reducing B16F10 cell adhesion, colonization, and migration. Based on these results, this study suggests that the nanoencapsulation of DIM into PO nanocapsules may be a promising approach in melanoma treatment. cancer neoplasms Hence 3,3diindolylmethane 33diindolylmethane diindolylmethane 3,3 3 DIMloaded loaded (PO cells Eudragit RS100. RS100 RS . RS100) Mediumchain Medium chain (MCT comparison <180 180 (<18 nm, nm , nm) <0.12 012 0 12 (<0.12 as scattering, scattering scattering) tested microelectrophoresis, microelectrophoresis microelectrophoresis) 5 5. potentiometry, potentiometry potentiometry) content 100 evaluated HPLC. HPLC HPLC) nonirritating non irritating according HETCAM HET CAM HET-CAM constitution Notably PObased based MCTcontaining containing radiation, radiation radiation) determined ) FRAP. FRAP FRAP) Additionally BF B F B16F1 IC 649 6 49 6.4 24 >2 µgmL µg mL µg/mL respectively, respectively respectively) adhesion colonization migration results treatment 3diindolylmethane 33 3, RS10 <18 18 (<1 <0.1 01 1 (<0.1 10 B16F 64 4 6. 2 > RS1 <1 (< <0. (<0. < ( <0 (<0

https://doi.org/10.1590/s2175-97902024e23931

15.

Development of spectroscopic methods for assessing polymorphic content of efavirenz
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Rosa, Talita Atanazio

; Oliveira, Marcos Victor Gregório de

; França, Leandro de Moura

; Lima, Maria Joanellys dos Santos

; Silva, Pollyne Amorim

; Silva, Rosali Maria Ferreira da

; Rolim, Larissa Araújo

; Pimentel, Maria Fernanda

; Rolim Neto, Pedro José

Brazilian Journal of Pharmaceutical Sciences

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2024, Volume 60 elocation e23487

Resumo: En | Texto: En | PDF: En

Abstract The present work aimed to develop a new method for assessing the content of mixtures of polymorphic forms I and II of the drug Efavirenz (EFV) by vibrational spectroscopic techniques such as Middle (MIR) and Near (NIR) infrared and Raman, using multivariate calibration models. Benchtop and handheld instruments were used for NIR and Raman and a benchtop instrument for MIR. In addition, VIP scores and iPLS, variable selection methods were employed. The infrared techniques showed the best models, with Root Mean Squares Error (RMSE) around 5% (w/w). When MIR and portable NIR instruments were used, this value was lowered to 4% (w/w) with selection of variables by iPLS. Raman spectroscopy showed higher error, even with selection of variables, possibly due to the spot laser size used by instruments and the lack of uniformity of the particle size in the samples. The infrared methods developed were shown to be effective in quantifying polymorphic mixtures of EFV. Given the ease of use of handheld instruments, they may be applied as tools of process analytical technology for monitoring quality control during industrial processing. EFV (EFV (MIR (NIR models addition iPLS employed RMSE (RMSE 5 w/w. ww w/w . w 4 (w/w error samples processing

https://doi.org/10.1590/s2175-97902024e23487

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