RESUMO Este estudo avaliou a eficácia da terapia com luz de baixo nível (LLLT) no tratamento de três pacientes com paralisia de Bell (PB) e revisou a literatura relevante. O primeiro caso envolveu uma mulher de 52 anos com PB grau V, que, após receber tratamento farmacológico e realizar sete sessões de LLLT (780 nm; 70 mW; E = 9 J), melhorou para grau II em 21 dias. O segundo caso foi de um homem de 37 anos que, após não ter apresentado resposta ao tratamento anteriormente, recebeu 24 sessões de LLLT e progrediu de grau V para grau II ao longo de 4 meses. O terceiro caso envolveu um homem de 40 anos que, após medicação e oito sessões de LLLT, melhorou de grau V para grau I em 1,5 meses. No geral, a LLLT demonstrou melhorar significativamente a função facial, a estética e o bem-estar geral desses pacientes em um período relativamente curto.

ABSTRACT This study evaluated the efficacy of low-level light therapy (LLLT) in the treatment of three patients with Bell's palsy (BP) and reviewed relevant literature. The first case involved a 52year-old woman with grade V BP, who, after receiving pharmacological treatment and undergoing seven sessions of LLLT (780 nm; 70 mW; E = 9 J), improved to grade II within 21 days. The second case was a 37-year-old man who, having previously shown no response to treatment, received 24 sessions of LLLT and progressed from grade V to grade II over the course of 4 months. The third case involved a 40-year-old man who, following medication and eight sessions of LLLT, improved from grade V to grade I in 1.5 months. Overall, LLLT was found to significantly enhance facial function, aesthetics, and overall well-being in these patients within a relatively short period.

RESUMEN Este estudio evaluó la eficacia de la terapia por luz de baja intensidad (LLLT, por sus siglas en inglés) en el tratamiento de tres pacientes con parálisis de Bell (BP) y revisó la literatura relacionada. Un caso involucró a una mujer de 52 años con BP grado V, quien, después de recibir terapia con medicamentos y siete sesiones de LLLT (780 nm; 70 mW; E = 9 J), mejoró al grado II en 21 días. Otro caso, un hombre de 37 años, previamente no receptivo a tratamientos, se sometió a 24 sesiones de LLLT, pasando del grado V al II en 4 meses. Finalmente, un hombre de 40 años tratado con medicamentos y 8 sesiones de LLLT mejoró del grado V al I en 1,5 meses. En esencia, la LLLT mejoró significativamente las funciones faciales, la estética y el bienestar general de los pacientes en un corto período de tiempo.

Resumo O pé em espelho é uma anomalia congênita rara, pertencente ao espectro das polidactilias complexas dos pés. Pode ocorrer isoladamente ou associado a outras malformações ou síndromes genéticas. Trata-se de um tema pouco descrito na literatura, com escassas publicações acerca do seu tratamento. Relatamos o caso de uma paciente do sexo feminino, de 4 anos de idade, que apresentava pé esquerdo com 8 dedos, sem outras deformidades associadas, cuja queixa incluía impossibilidade do uso de calçados fechados e estigma social. Radiograficamente, verificou-se a presença de oito metatarsos com suas respectivas falanges, cinco ossos cuneiformes e ausência de deformidades ósseas no retropé. Optou-se pela abordagem cirúrgica visando uma melhoria funcional e estética, bem como melhor adaptação ao uso de calçados fechados, conforme desejo da paciente e de sua família. Foi realizada incisão em "V" dorsal e plantar com ressecção de três raios supranumerários, incluindo três metatarsos centrais com suas nove falanges correspondentes, dois ossos cuneiformes, tendões e nervos digitais excedentes, seguida da sutura dos ligamentos intermeta-tarsais, com preservação dos dedos com aparência normal, diminuição da largura do pé e manutenção do seu apoio adequado. A redução foi mantida por fixação transmetatarsal com fios de Kirschner. O pós-operatório seguiu com o uso de tala bota e carga zero, sem intercorrências; os fios de Kirschner foram retirados, e a carga no membro foi liberada após 12 semanas. rara pés genéticas Tratase Trata se literatura tratamento feminino idade associadas social Radiograficamente verificouse verificou retropé Optouse Optou estética família V "V supranumerários correspondentes excedentes intermetatarsais, intermetatarsais intermeta tarsais, tarsais intermeta-tarsais normal adequado pósoperatório pós operatório zero intercorrências retirados 1 semanas

Abstract Mirror foot is a rare congenital anomaly within the spectrum of complex polydactyly of the foot. It can occur alone or with other malformations or genetic syndromes. It is a little described topic in the literature, with few publications on its treatment. We report the case of a 4-year-old female patient who presented eight fingers on her left foot and no other associated deformities. Her complaints included the impossibility of wearing closed shoes and social stigma. Radiography revealed eight metatarsals with their respective phalanges, five cuneiform bones, and the absence of bone deformities in the hindfoot. We opted for a surgical approach aiming at functional and esthetic improvement, in addition to better adaptation to closed shoes, as desired by the patient and her family. We performed a dorsal and plantar "V" incision and resected three supernumerary rays, including three central metatarsals with their nine corresponding phalanges, two cuneiform bones, tendons, and excess digital nerves. Next, we sutured the intermetatarsal ligaments, preserving the fingers with a normal appearance, reducing the width of the foot, and preserving adequate support. Kirschner wires maintained the reduction by transmetatarsal fixation. During the postoperative period, the patient wore a boot splint with zero load with no complications. We removed the Kirschner wires and allowed load on the limb after 12 weeks. syndromes literature treatment 4yearold yearold 4 year old stigma phalanges bones hindfoot improvement family V "V rays tendons nerves Next ligaments appearance support fixation period complications 1 weeks

Resumo O presente artigo trata dos principais desafios para o adequado funcionamento das audiências de custódia no Distrito Federal (DF). Adotou-se como metodologia a análise de conteúdo de publicações institucionais e acadêmicas sobre audiências de custódia no DF entre 2017 e 2022. Foram identificadas as seguintes categorias, representando os principais desafios das audiências de custódia no DF: (i) manutenção do uso de algemas nos custodiados durante a audiência; (ii) uso desmedido (e presumido) de medidas cautelares; (iii) violências no ato de prisão e durante a detenção; (iv) silenciamento do custodiado; e (v) o perfil dos custodiados. Conclui-se que, embora a própria existência e o funcionamento deste instituto processual fortaleçam o acesso à justiça das pessoas investigadas, bem como prevaleçam decisões pela liberdade provisória no DF, ainda assim existem obstáculos jurídicos, político-criminais e institucionais que desafiam a consecução dos objetivos das audiências de custódia. DF. . (DF) Adotouse Adotou se 201 2022 categorias i (i audiência ii (ii presumido cautelares iii (iii detenção iv (iv custodiado v (v Concluise Conclui investigadas jurídicos políticocriminais político criminais (DF 20 202 2

Abstract This article addressed the main challenges for the proper functioning of pre-trial detention hearings in the Federal District (DF). The methodology adopted was a content analysis of publications onl custody hearings in the Federal District between 2017 and 2022. The following categories were identified, representing the main challenges of pre-trial detention hearings in the Federal District: (i) maintaining the use of handcuffs during the hearing; (ii) the excessive (and presumed) use of precautionary measures; (iii) violence in the act of arrest and during detention; (iv) silencing of the custodian; and (v) the profile of the custodians. It is concluded that, although the very existence and functioning of this procedural institute strengthens the access to justice of the investigated people, as well as decisions for provisional freedom prevail in the DF, there are still legal, political-criminal and institutional obstacles that challenge the achieving the objectives of the escrow hearings. pretrial pre trial DF. DF . (DF) 201 2022 identified i (i hearing ii (ii presumed measures iii (iii iv (iv custodian v (v custodians people legal politicalcriminal political criminal (DF 20 202 2

RESUMO Processo de salinização do solo afeta negativamente o crescimento e o rendimento de culturas economicamente valiosas, como a soja. Com o objetivo de minimizar os danos causados pelo estresse salino e melhorar o desempenho das culturas, novas tecnologias estão sendo desenvolvidas. Neste contexto, o uso de bioestimulantes na agricultura pode oferecer uma alternativa para mitigar os efeitos deletérios da salinidade. O extrato da alga Ascophyllum nodosum e substâncias húmicas (ácidos fúlvicos) são comumente empregados. Portanto, o estudo teve como objetivo avaliar a ação de um bioestimulante composto pelo extrato da alga marinha A. nodosum e ácidos fúlvicos aplicados em diferentes estádios fenológicos sobre parâmetros biométricos, bioquímicos e fisiológicos da soja (Glycine max) submetida à irrigação com água salina. O delineamento experimental utilizado foi inteiramente casualizado em esquema fatorial 3 x 2 + 2, referente a três aplicações do bioestimulante em diferentes estádios fenológicos da soja: V3, V3R1 e V3R1R4, dois níveis de condutividade elétrica da água de irrigação (CEa): 0,5 (S0) e 5,0 dS m-1 (S1), dois controles adicionais, um com controle positivo (PC) e outro com controle negativo (NC). O experimento contou com cinco repetições e uma planta por parcela. Os resultados deste estudo sugerem que a aplicação do bioestimulante pode ser uma alternativa na mitigação dos efeitos nocivos do estresse salino em soja. Os resultados foram obtidos com a aplicação V3R1 nos parâmetros diâmetro do caule, área foliar, massa seca da parte aérea, extravasamento de eletrólitos e clorofila b representam maior eficiência na mitigação dos efeitos nocivos da salinidade no cultivo da soja. valiosas desenvolvidas contexto empregados Portanto A biométricos Glycine max salina V3 V VR R V3R V3R1R4 VRR CEa (CEa) 05 0 5 0, S0 S (S0 50 5, m1 m 1 m- S1, S1 , (S1) adicionais PC (PC NC. NC . (NC) parcela caule foliar aérea V3R1R (CEa (S (S1 (NC

ABSTRACT Soil salinization negatively affects the growth and yield of economically valuable crops such as soybeans. New technologies are being developed to minimize the damage caused by saline stress and improve crop performance. Therefore, the use of biostimulants in agriculture may offer an alternative method to mitigate the deleterious effects of salinity. Extracts of the seaweed, Ascophyllum nodosum and humic substances (fulvic acids) are commonly used. Therefore, this study aimed to evaluate the action of a biostimulant composed of A. nodosum seaweed extract and fulvic acid applied at different phenological stages on the biometric, biochemical, and physiological parameters of soybeans (Glycine max) subjected to irrigation with saline water. The experimental design used was completely randomized in a 3 × 2 + 2 factorial scheme, referring to three applications of the biostimulant at different soybean phenological stages: V3, V3R1, and V3R1R4, two levels of electrical conductivity of irrigation water (ECw): 0.5 (S0) and 5.0 dS m-1 (S1), two additional controls, one with a positive control (PC) and the other with a negative control (NC). The experiment had five replicates with one plant per plot. The results of this study suggest that the application of the biostimulant can mitigate the harmful effects of salt stress in soybeans. The results obtained with V3R1 application in the parameters stem diameter, leaf area, shoot dry mass, electrolyte leakage, and chlorophyll b represent greater efficiency in mitigating the harmful effects of salinity in soybean cultivation. performance Therefore acids A biometric biochemical Glycine max scheme V3 V VR R V3R1R4 VRR ECw (ECw) 05 0 5 0. S0 S (S0 50 5. m1 m 1 m- S1, S1 , (S1) controls PC (PC NC. NC . (NC) plot V3R diameter area mass leakage cultivation V3R1R (ECw (S (S1 (NC

Abstract Introduction: Fenestrated and branched stent graft technology has come a long way over the past few years, enabling the treatment of complex juxtarenal aneurysms, thoracoabdominal aneurysms, and arch pathologies. Many innovations have been developed, namely device and delivery optimization and technical tricks. These concepts have proven to work well when there is sufficient time to plan and manufacture a custom-made device for the patient. However, this is different in urgent or emergent cases. Using parallel graft techniques or off-the-shelf stent grafts may be efficient in urgent situations, but it is also associated with selection limitations. Recent publications have demonstrated similar mid-term technical and clinical results between physician-modified endografts (PMEGs) and customized devices. The authors aim to describe their institutional series of PMEGs. Methods: The clinical files of all patients undergoing PMEGs were consulted, and demographic data as surgery outcomes were collected. Technical success: creating the intended number of fenestrations, target vessel catheterization, and patency. Procedural success: technical success with adequate aneurysm exclusion and without endoleak in the final angiography. 30-day complications and mortality were also evaluated. Technical and procedural success were assessed, as well as morbidity and mortality. Results: Between December 2020 and December 2022, 3 patients underwent PMEGs. The indications were a juxtarenal aortic aneurysm, a type V thoracoabdominal aneurysm and a persistent type 1a endoleak. All patients were symptomatic, with one stable rupture. All cases were performed with technical and procedural success and no morbidity and mortality at 30 days. Conclusion: Stent graft modification is a valuable and valid tool in emergencies and should be a vascular surgeon's trump card when dealing with complex aortic pathologies. Nevertheless, due to the absence of long-term evidence, it should be reserved for acute patients unfit for open repair and in aneurysms with unfavorable anatomy for an off-the-shelf device.

Abstract Introduction: Spinal cord ischemia (SCI) is an uncommon but one of the most terrifying complications associated with the treatment of extensive aortic aneurysms. Its pathophysiology, risk factors, and event characteristics must be clarified. This study aimed to perform a descriptive analysis of the cases of SCI after complex aortic repair at our center and to understand which factors contributed to the event. Methods: A retrospective, single-center, cohort study of prospectively collected data was performed. From January 2013 to October 2022, we included all consecutive patients with thoraco-abdominal aneurysms (TAAA) and complex abdominal aneurysms submitted to an endovascular procedure using fenestrated or branched endografts. According to the Society for Vascular Surgery (SVS) reporting standards, SCI was defined as the development of new motor or sensitive deficits after endovascular treatment. Results: One hundred and thirty-five patients (87% male) were included, with a median age of 72. A total of 53,7% (n=72) had thoraco-abdominal aneurysms (type I-V), of which 63 were extent I-III\V and 9 were extent IV. In total, 12 (9%) SCI events were identified; 7 patients had a grade 2 SCI, 5 had a grade 3 injury, and all of them had a TAAA. Of these, 10 had pre-procedure cerebrospinal fluid (CSF) drainage. Five (42%) developed symptoms after 48 hours (delayed SCI), and seven patients developed early SCI, being identified on the first evaluation after surgery. Five cases received rescue CSF drainage (after the beginning of symptoms), with some degree of improvement observed in all cases. Among patients with grade 2 SCI (n=7), five recovered completely, one recovered partially (maintaining sensitive symptoms - grade 1), and one did not recover. This corresponded to an overall incidence of permanent SCI of 5.2% (n=7, any grade) and 1.5% of permanent paraplegia (n=2, grade 3, 2.8% only in TAAA). Conclusion: In this study, SCI only occurred in patients with TAAA, and the incidence of permanent paraplegia in this group was 2,8%. In five patients, rescue CSF drainage was applied, with some degree of clinical improvement. The small number of events precluded the investigation of predictors. Notably, 42% of SCI cases happened after 48 hours, showing a high prevalence of delayed SCI in this population. Consequently, more extended monitoring of these patients should be considered.

RESUMO O objetivo deste estudo foi avaliar os efeitos de diferentes colorações e manejos de coberturas de tela não-tecida, e de dois diferentes sistemas de irrigação localizada sobre características fisiológicas e produção de frutos do tomateiro industrial. O experimento foi instalado em delineamento de blocos ao acaso, com 4 repetições, em parcelas subdivididas. Gotejamentos superficial e subterrâneo foram utilizados nas parcelas; e 5 estratégias de cobertura da planta com tela não-tecida nas subparcelas: i) sem cobertura; ii) cobertura com tela não-tecida branca; iii) tela não-tecida branca, retirado entre 30 e 60 dias após o transplante; iv) tela não-tecida vermelha; v) tela não-tecida vermelha, retirado entre 30 e 60 dias após o transplante. Avaliou-se: taxa fotossintética, de transpiração e de transporte de elétrons; condutância estomática; concentração de carbono; produção total de frutos e eficiência do uso da água. Foram utilizados ANOVA e teste de Scott-Knott. A transpiração é favorecida pelas coberturas brancas, a condutância estomática, pelas coberturas brancas e vermelha ininterrupta, porém a produtividade não é influenciada pelas coberturas, exceto a vermelha, retirada entre 30 e 60 dias após transplante, que é a pior condição para o tomate industrial. Irrigações superficial e subterrânea podem ser utilizadas com mesma eficiência. nãotecida, nãotecida tecida, tecida industrial acaso repetições subdivididas subparcelas i ii branca iii 3 6 transplante iv v Avaliouse Avaliou se Avaliou-se fotossintética elétrons estomática carbono água ScottKnott. ScottKnott Scott Knott. Knott Scott-Knott ininterrupta

ABSTRACT This study aimed to evaluate the effects of different colors and management of polypropylene non-woven fabric coverings and two different localized irrigation systems on the physiological characteristics and yield of industrial tomatoes. The experiment was installed in a randomized block design arranged in a split-plot scheme with four replications. Surface and subsurface drip were used in the plots, and five plant cover strategies with non-woven fabric in the subplots: i) without non-woven fabric; ii) coverage with white non-woven fabric; iii) coverage with white non-woven fabric, removed between 30 and 60 days after transplanting the seedlings; iv) coverage with red non-woven fabric; v) coverage with red non-woven fabric, removed between 30 and 60 days after transplanting. Photosynthesis, transpiration, electron transport rate, stomatal conductance, carbon concentration, total fruit yield, and water use efficiency were evaluated. ANOVA and the Scott-Knott test were used. Transpiration is favored by the white non-woven fabric and the stomatal conductance by the white and uninterrupted red one. However, the tomato yield is not influenced by the coverings, except for the red one, removed only between 30 and 60 days after transplanting, which is the worst condition for industrial tomato production. Surface and subsurface irrigation can be used with the same efficiency. nonwoven non woven tomatoes splitplot split plot replications plots subplots i ii iii 3 6 seedlings iv v Photosynthesis transpiration rate concentration evaluated ScottKnott Scott Knott one However production

Resumen El herbicida tembotrione tiene un buen control de malezas y puede ser una herramienta importante en el cultivo del sorgo. Sin embargo, este herbicida está registrado en Brasil solo para maíz. Este estudio tuvo como objetivo evaluar la selectividad de la tembotrione asociada a la atrazine en diferentes dosis y etapas de desarrollo del grano de sorgo. Se realizaron dos experimentos en Rio Verde-GO y Montividiu-GO, Brasil en 2018. Se adoptó un diseño de bloques al azar con cuatro repeticiones, en un factorial 3x2+1+1, con tres etapas de desarrollo (V3, V5 y V7), dos dosis de tembotrione (37,8 y 75,6 g ha-1) asociada al herbicida atrazine (1,000 g ha-1), un tratamiento adicional con solo atrazine en V3 más un testigo sin herbicida. Los resultados permitieron observar síntomas visibles de fitotoxicidad cuando se aplicó la asociación entre los herbicidas tembotrione y atrazine en la etapa V3 y V5. Los síntomas incluyeron reducciones en la altura de la planta y el diámetro del tallo del sorgo y reducciones en la longitud de la panícula con la aplicación en la etapa V5. La aplicación de tembotrione en asociación con atrazine en V3 y V5 resultó en una reducción de la acumulación de masa seca en la parte aérea de las plantas de sorgo, pero sin influencia en la masa de mil granos, independientemente de la etapa de aplicación. El herbicida tembotrione en dosis de 37,8 g ha-1 en asociación con atrazine en dosis de 1,000 g ha-1 fue selectivo para sorgo en grano cuando se aplicó en V7, sin causar reducción en el rendimiento de grano.

Abstract The herbicide tembotrione is effective against grassy weeds constituting an important tool in sorghum crops. However, in Brazil, this herbicide is only registered for corn. This study aimed to evaluate the selectiveness of tembotrione combined with atrazine at different doses and developmental stages of grain sorghum. Two experiments were conducted in Rio Verde and Montividiu, state of Goiás, Brazil, in 2018. A randomized block design with four replications, in a 3x2+1+1 factorial arrangement, tested three developmental stages (V3, V5 and V7), two doses of tembotrione (37.8 and 75.6 g ha-1) combined with the herbicide atrazine (1,000 g ha-1), an additional treatment only with atrazine at V3 and a control, free of herbicide. Evident phytotoxicity was observed with the combination of tembotrione and atrazine at V3 and V5 stages. Symptoms included reductions in plant height, sorghum stem diameter, panicle length, and cumulative dry mass of sorghum plant shoots. However, there was no influence on thousand grains mass, regardless of application stages. Tembotrione at 37.8 g ha-1 combined with atrazine at 1,000 g ha-1 was selective for grain sorghum when applied at V7, without affecting grain yield.

RESUMO: Ultimamente, a produção de soja irrigada tem aumentado, portanto, ferramentas que auxiliem na gestão dos recursos hídricos devem ser aprimoradas. Foram realizados dois experimentos, o primeiro de maio a agosto e o segundo de setembro a dezembro de 2019. O delineamento experimental foi em blocos casualizados com cinco tratamentos e quatro repetições. No tratamento testemunha (SE), a irrigação foi realizada para atender a demanda hídrica da cultura durante todas as fases de crescimento. Nos demais tratamentos, a irrigação foi interrompida em determinados estádios de desenvolvimento da cultura (TI = VC-V4, TII = V5-R1, TIII = R1-R5 e TIV = R5-R7) e, a seguir, restabelecida. Após a calibração, o modelo estimou satisfatoriamente a cobertura do dossel, a biomassa e a produtividade da soja, com altos valores de coeficientes de determinação (r² > 0,90), baixos valores de RMSE e MBE e altos valores de EF. No experimento 1, o teor de água do solo foi superestimado nos tratamentos SE, TI e TIV em 0,24%, 0,78% e 0,23%, respectivamente, e subestimado em 3,3% e 5,5% nos tratamentos TII e TIII, respectivamente. No experimento 2, nos tratamentos SE, TI, TII, TIII e TIV, o teor de água no solo foi subestimado em 6%, 3%, 4,6%, 5,9% e 6,7%, respectivamente. A evapotranspiração real foi superestimada em todos os tratamentos em ambos os experimentos, com baixos valores de r² em ambos os experimentos 1 (0,11- 0,23) e 2 (0,04 - 0,21). RESUMO Ultimamente aumentado portanto aprimoradas 2019 repetições SE , (SE) crescimento VCV4, VCV4 VCV VC V4, V4 V VC-V4 V5R1, V5R1 VR V5 R1, R1 R V5-R1 R1R5 RR R5 R1-R R5R7 R7 R5-R7 seguir restabelecida calibração dossel r (r 0,90, 090 0,90 0 90 0,90) EF 024 24 0,24% 078 78 0,78 023 23 0,23% respectivamente 33 3 3,3 55 5 5,5 6 6% 3% 46 4 4,6% 59 9 5,9 67 7 6,7% 0,11 011 11 (0,11 0,23 0,04 004 04 (0,0 0,21. 021 0,21 . 21 0,21) 201 (SE VC-V V5R V5-R R1R R5R R5-R 09 0,9 02 0,24 07 0,7 3, 5, 4,6 6,7 0,1 01 (0,1 0,2 0,0 00 (0, 20 0, 4, 6, (0 (

ABSTRACT: Lately, irrigated soybean production has increased; therefore, tools that can aid water resources management must be improved. Two experiments were carried out, the first one from May to August and the second one from September to December 2019. The experimental design included randomized blocks with five treatments and four replicates. In the control treatment (SE), irrigation was carried out to meet the crop’s water demand during all growth stages. In the other treatments, irrigation was interrupted at specific crop growth stages (TI = VC-V4, TII = V5-R1, TIII = R1-R5, and TIV = R5-R7), and then restored. After calibration, the model satisfactorily estimated the canopy cover, biomass, and soybean yield, with high values of determination coefficients (r² > 0.90), low RMSE and MBE values, and high values of EF. In experiment 1, the soil water content was overestimated in the SE, TI, and TIV treatments by 0.24%, 0.78%, and 0.23%, respectively, and underestimated by 3.3% and 5.5% in the TII and TIII treatments, respectively. In experiment 2, in the SE, TI, TII, TIII, and TIV treatments, the soil water content was underestimated by 6%, 3%, 4.6%, 5.9%, and 6.7%, respectively. Real evapotranspiration was overestimated in all treatments in both experiments, with low r² values in both experiments 1 (0.11- 0.23) and 2 (0.04 - 0.21). ABSTRACT Lately increased therefore improved 2019 replicates SE , (SE) crops s TI VCV4, VCV4 VCV VC V4, V4 V VC-V4 V5R1, V5R1 VR V5 R1, R1 R V5-R1 R1R5, R1R5 RR R5, R5 R1-R5 R5R7, R5R7 R7 R5-R7) restored calibration cover biomass yield r (r 0.90, 090 0.90 0 90 0.90) EF 024 24 0.24% 078 78 0.78% 023 23 0.23% respectively 33 3 3.3 55 5 5.5 6 6% 3% 46 4 4.6% 59 9 5.9% 67 7 6.7% 0.11 011 11 (0.11 0.23 0.04 004 04 (0.0 0.21. 021 0.21 . 21 0.21) 201 (SE VC-V V5R V5-R R1R R1-R R5R R5-R7 09 0.9 02 0.24 07 0.78 3. 5. 4.6 5.9 6.7 0.1 01 (0.1 0.2 0.0 00 (0. 20 R5-R 0. 0.7 4. 6. (0 (

ABSTRACT Objective To evaluate the in vitro and in vivo toxicities of polyethylene glycol-coated gold nanoparticles synthesized using a one-step process. Methods Gold nanoparticles were prepared via a co-precipitation method using polyethylene glycol, and the synthesis product was characterized. For the in vitro evaluation, a flow cytometry analysis with Annexin V and iodide propidium staining was used to assess cytotoxicity in MG-63 cells labeled with 10, 50, and 100µg/mL of nanoparticle concentration. For the in vivo evaluation, nanoparticles were administered intraperitoneally at a dose of 10mg/kg dose in 10-week-old mice. Toxicity was assessed 24 hours and 7 days after administration via histopathological analysis of various tissues, as well as through renal, hepatic, and hematopoietic evaluations. Results Synthesized nanoparticles exhibited different hydrodynamic sizes depending on the medium: 51.27±1.62nm in water and 268.12±28.45nm (0 hour) in culture medium. They demonstrated a maximum absorbance at 520nm and a zeta potential of -8.419mV. Cellular viability exceeded 90%, with less than 3% early apoptosis, 6% late apoptosis, and 1% necrosis across all labeling conditions, indicating minimal cytotoxicity differences. Histopathological analysis highlighted the accumulation of nanoparticles in the mesentery; however, no lesions or visible agglomeration was observed in the remaining tissues. Renal, hepatic, and hematopoietic analyses showed no significant differences at any time point. Conclusion Polyethylene glycol-coated gold nanoparticles exhibit extremely low toxicity and high biocompatibility, showing promise for future studies. glycolcoated glycol coated onestep one step process coprecipitation co precipitation characterized evaluation MG63 MG 63 MG-6 10 50 100µgmL µgmL 100µg mL µg concentration 10mgkg mgkg 10mg kg mg 10weekold weekold week old mice 2 tissues renal hepatic evaluations medium 5127162nm nm 51 27 1 62nm 268122845nm 268 12 28 45nm 0 ( hour 8.419mV. 8419mV mV 8 419mV -8.419mV 90 90% 3 apoptosis 6 conditions mesentery however Renal point biocompatibility studies MG6 MG- 5 26 8.419mV 9

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/REF-1) is a multifunctional protein acting on cellular signaling pathways, including DNA repair and redox activities. APE1/REF-1 has emerged as a target for cancer therapy, and its role in breast cancer models would reveal new strategies for cancer therapy. APX2009 is a specific APE1/REF-1 redox inhibitor whose anticancer properties have not been described in breast cancer cells. Here, we investigated the effect of the APX2009 treatment in the breast cancer cell lines MDA-MB-231 and MCF-7. Breast cancer cell lines were cultured, and WST1 and colony formation assays were performed to evaluate cell proliferation. Annexin V-FITC/7-AAD and LDH-Glo™ assays were performed to evaluate cell death. The wound healing assay and Matrigel transwell assay were performed after APX2009 treatment to evaluate the cellular migration and invasion processes, respectively. Our findings demonstrated that APX2009 treatment decreased breast cancer cell proliferative, migratory, and invasive properties. Furthermore, it induced apoptosis in both cell lines. Our study is the first to show the effects of APX2009 treatment on apoptosis in a breast cancer cell. Therefore, this study suggested that APX2009 treatment is a promising anticancer molecule for breast cancer. Apurinicapyrimidinic Apurinic apyrimidinic 1redox 1 factor1 factor factor- APE1/REF1 APE1REF1 APEREF APE1/REF APE1 REF APE (APE1/REF-1 pathways activities APE1/REF- therapy APX APX200 cells Here MDAMB231 MDAMB MDA MB 231 MDA-MB-23 MCF7. MCF7 MCF 7. 7 MCF-7 cultured WST proliferation VFITC/7AAD VFITC7AAD VFITCAAD V FITC/7 AAD FITC LDHGlo™ LDHGlo LDH Glo™ Glo LDH-Glo death processes respectively proliferative migratory Furthermore Therefore REF1 APE1REF (APE1/REF- APX20 MDAMB23 23 MDA-MB-2 MCF- VFITC 7AAD FITC7 FITC/ (APE1/REF APX2 MDAMB2 2 MDA-MB- MDA-MB

Abstract Since the 1970s, maternal corticosteroid therapy has been used successfully to induce labor. This allows for better monitoring of parturients and provision of first aid to neonates, improving neonatal viability, as this treatment induces maturation in a variety of fetal tissues, thereby reducing morbidity and mortality. Although the effects of corticosteroids are well known, few studies have investigated the influence of this therapy in Santa Inês sheep. This study aimed to evaluate the efficacy of dexamethasone at two doses (8 and 16 mg) to induce lambing in Santa Inês ewes at 145 days of gestation and assess its effects on neonatal vitality. For this study, 58 ewes raised in an extensive system were investigated. Pregnancy was confirmed after artificial insemination at a set time or after controlled mounting. Ewes were separated into three groups: an untreated control group (G1: 0 mg) and groups treated with two doses of dexamethasone (G2: 8 mg and G3: 16 mg). In total, 79 lambs were born. Their vitality was assessed based on their Apgar score, weight, temperature, and postnatal behavior. SAS v9.1.3 (SAS Institute, Cary, NC) was used to analyze data, considering a 5% significance level for all analyses. The births in the induced groups occurred 48.4 ± 22.1 h after induction, while the ewes that underwent non-induced labor gave birth 131.96 ± 41.9 h after placebo application (p < 0.05), confirming the efficacy of dexamethasone to induce and synchronize labor. The induced and non-induced neonates had similar Apgar scores, temperatures, weights, and postnatal behavioral parameters (p > 0.05). This study showed that inducing labor in Santa Inês ewes at 145 days of gestation with a full (16 mg) or half dose (8 mg) of dexamethasone is an effective technique and does not compromise neonate vitality. 1970s s viability tissues mortality known sheep ( 1 14 5 mounting G1 G (G1 G2 (G2 G3 mg. . total 7 born score weight temperature behavior v913 v v9 3 v9.1. Institute Cary NC data analyses 484 48 4 48. 221 22 22. induction noninduced non 13196 131 96 131.9 419 41 9 41. p 0.05, 005 0.05 , 05 0.05) scores temperatures weights 0.05. (1 (G v91 v9.1 2 1319 13 131. 00 0.0 v9. 0.

RESUMO O estudo objetivou explorar fatores que influenciam a adoção das métricas de valor de tecnologia da informação em organizações brasileiras, utilizando amostra não probabilística de 28 empresas de médio e grande porte, tendo como base os pressupostos da Teoria Neo-Institucional (isomorfismo) e os impactos decorrentes da transformação digital. Foi utilizado questionário com 16 questões fechadas e uma aberta, construído a partir de pesquisas realizadas por empresas de consultoria de grande porte e institutos internacionais de pesquisas, além dos próprios fundamentos da Teoria Neo-Institucional. Os dados e os resultados alcançados permitiram-nos chegar aos seguintes achados: (i) prevalência do isomorfismo mimético; (ii) a legitimação da Tecnologia da Informação como motivador para comunicação do valor gerado; (iii) importância atribuídas às métricas de operação e suporte; (iv) a troca de experiência entre pares se sobrepõe a busca de fontes acadêmicas ou de pesquisas científicas, caracterizando isomorfismo normativo; e (v) negação dos impactos da transformação digital na forma de mensurar valor de tecnologia da informação. brasileiras 2 NeoInstitucional Neo Institucional (isomorfismo 1 aberta NeoInstitucional. Institucional. permitiramnos permitiram nos achados i (i mimético ii (ii gerado iii (iii suporte iv (iv científicas normativo v (v

ABSTRACT The study aimed to explore factors that influence the adoption of information technology value metrics in Brazilian organizations, using a non-probabilistic sample of 28 medium and large companies, based on the assumptions of the Neo-Institutional Theory (isomorphism) and the impacts resulting from digital transformation. We used sixteen closed questions plus one open question survey, created from research conducted by large consulting companies and international research institutes, in addition to the very foundations of Neo-Institutional Theory. The data and results achieved allowed us to reach the following findings: (i) prevalence of mimetic isomorphism; (ii) the legitimization of Information Technology as a motivator for communicating the value generated; (iii) the importance attributed to operation and support metrics; (iv) the exchange of experience between peers overlaps with the search for academic sources or scientific research, characterizing normative isomorphism; and (v) the denial of the impacts of digital transformation on the way of measuring the value of information technology. organizations nonprobabilistic non probabilistic 2 NeoInstitutional Neo Institutional isomorphism (isomorphism survey institutes findings i (i ii (ii generated iii (iii iv (iv v (v

Resumo Na agricultura de precisão, um dos maiores problemas é a necessidade de uma grade amostral densa. Uma solução para este impasse tem sido a geração de zonas de gestão e a correlação entre elas. Este trabalho tem como objetivo definir zonas de manejo para a cultura do mamoeiro utilizando o método de agrupamento fuzzy C-means, baseado nos seguintes atributos do solo: fósforo, cálcio, magnésio e potássio; e saturação de bases. O trabalho foi conduzido em uma área de aproximadamente 1,2 ha plantada com cultura comercial de Carica papaya L. cultivada em Argissolo típico encontrado em terraços costeiros, no município de São Mateus, ES, Brasil. As zonas de manejo foram definidas pelo método proposto, com base nas seguintes análises: parâmetros químicos do solo P, Ca, Mg e saturação por bases (V), analisados em conjunto; parâmetros químicos do solo P, Ca, Mg e V, analisados separadamente; e, as seguintes combinações de atributos químicos do solo Ca-Mg, Ca-V, Ca-Mg-V, P-Ca, P-Mg, P-V, P-Ca-Mg, P-Ca-V, Mg-V, e P-Ca-Mg-V. As zonas de manejo geradas permitiram explicar a variabilidade espacial dos atributos na área de estudo e as semelhanças observadas entre as zonas de manejo geradas a partir de diferentes atributos, além disso, os dados foram influenciados especialmente pelos atributos P e V%. precisão densa elas Cmeans, Cmeans C means, means C-means fósforo cálcio potássio 12 1 2 1, L costeiros Mateus ES Brasil proposto análises Ca V , (V) conjunto separadamente CaMg, CaMg Mg, Ca-Mg CaV, CaV Ca-V CaMgV, CaMgV Ca-Mg-V PCa, PCa P-Ca PMg, PMg P-Mg PV, PV P-V PCaMg, PCaMg P-Ca-Mg PCaV, PCaV P-Ca-V MgV, MgV Mg-V PCaMgV. PCaMgV V. P-Ca-Mg-V disso V% (V

Abstract In precision agriculture, one of the major problems is the need for a dense sampling grid. A solution to this problem has been the generation of management zones and the correlation between them. This work aims at defining management zones for a papaya culture using the fuzzy C-means grouping method, based on the following soil attributes: phosphorus, calcium, magnesium and potassium; and base saturation. The work was conducted in an approximately 1.2 ha area planted with a commercial culture of Carica papaya L. cultivated in typical Argisol found on the coastal terraces, in the municipality of São Mateus, ES, Brazil. The management zones were defined by the proposed method, based on the following analyses: soil chemical parameters P, Ca, Mg, and base saturation (V), analyzed together; soil chemical parameters P, Ca, Mg, and V, analyzed separately; and, the following combinations of soil chemical attributes Ca-Mg, Ca-V, Ca-Mg-V, P-Ca, P-Mg, P-V, P-Ca-Mg, P-Ca-V, Mg-V, and P-Ca-Mg-V. The generated management zones facilitated an understanding of the spatial variability of the attributes in the study area and the observed similarities between management zones generated from different attributes. In addition, the data were influenced especially by the P and V% attributes. agriculture grid them Cmeans C means method phosphorus calcium potassium 12 1 2 1. L terraces Mateus ES Brazil analyses Ca Mg V , (V) together separately CaMg, CaMg Ca-Mg CaV, CaV Ca-V CaMgV, CaMgV Ca-Mg-V PCa, PCa P-Ca PMg, PMg P-Mg PV, PV P-V PCaMg, PCaMg P-Ca-Mg PCaV, PCaV P-Ca-V MgV, MgV Mg-V PCaMgV. PCaMgV V. P-Ca-Mg-V addition (V

Complex oxides can present interesting semiconductor properties since the simultaneous presence of different metallic cations can modulate the conduction and valence band edges, affecting the bandgap energy, the onset potential for reactions and also the photocatalyst long-term stability. Here, we demonstrated that the synthesis of multinary oxides, very challenging using “traditional” methodologies, can be fast achieved by melting the precursor binary oxides in an arc furnace. As a proof of concept, arc-melting a mixture of Bi2O3 and V2O5 (Bi:V molar ratio of 1:1.05) resulted in almost pristine BiVO4 (97.3% from Rietveld refinement of X-ray diffraction (XRD) data); photoelectrochemical (PEC) measurements indicated a promising application as a photoanode for O2 evolution reaction. Conversely, the arc-melting of Bi2O3 and WO3 mixture (Bi:W molar ratio of 2:1.15) resulted in the biphasic Bi2WO6/Bi2W2O9; preliminary PEC analysis revealed characteristics of n-type semiconductor electrode with photoactivity under UV irradiation. Finally, the hierarchical Ag@α-AgVO3/Fe2O3 consisted of micrometric Fe2O3 particles decorated by AgVO3 nanoribbons and Ag nanoparticles, was obtained from melting Ag2O, Fe2O3 and V2O5 as precursors (Ag:Fe:V molar ratio of 3:1:2); PEC measurements also revealed possible application as a photoanode. The results for these three materials demonstrated the arc-synthesis as a fast, effective and scalable methodology for synthesizing complex oxides. edges energy longterm long term stability Here traditional “traditional methodologies furnace concept arcmelting BiO Bi O Bi2O VO V V2O BiV 11.05 1105 1 1.05 05 1:1.05 BiVO 97.3% 973 97 3 (97.3 Xray X ray XRD (XRD data data) (PEC reaction Conversely WO BiW W 21.15 2115 2 1.15 15 2:1.15 Bi2WO6/Bi2W2O9 Bi2WO6Bi2W2O9 BiWOBiWO Bi2WO6 Bi2W2O9 ntype n type irradiation Finally Ag@αAgVO3/Fe2O3 AgαAgVO3Fe2O3 AgαAgVOFeO Ag@α AgVO3/Fe2O3 α AgVO Fe Ag@α-AgVO3/Fe2O FeO Fe2O nanoparticles Ag2O AgO AgFeV 312 3:1:2) arcsynthesis 11 11.0 110 105 1.0 0 1:1.0 97.3 9 (97. 21 21.1 211 115 1.1 2:1.1 Bi2WO6/Bi2W2O Bi2WO6Bi2W2O BiWO Bi2WO Bi2W2O αAgVO3 αAgVO Ag@αAgVO3/Fe2O AgαAgVO AgαAgVO3Fe2O Agα AgVO3Fe2O3 AgVOFeO AgVO3/Fe2O 31 3:1:2 11. 10 1. 1:1. 97. (97 21. 2:1. AgVO3Fe2O 3:1: 1:1 (9 2:1 3:1 1: ( 2: 3: