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This study highlights the synthesis of innovative polyurethane materials derived from Moringa oleifera oils extracted from two distinct sources. The oils were converted into their respective polyols through the in situ generated performic acid method. Diverse material characteristics were observed due to different agroclimatic and cultivation conditions for the sources. Extraction yields were 45.21% (source 1) and 40.32% (source 2), with acid values of 28.70 and 26.00 mg KOH per g of oil, respectively. Oleic acid constituted 79.87 and 67.11% of the oils composition, respectively. Nuclear magnetic resonance and Fourier transform infrared spectroscopy (FTIR) confirmed the hydroxylation of the oils. FTIR also identified the isocyanate structures in the synthesized polyurethane materials. Gel permeation chromatography analysis revealed a higher oligomer content in the polyol synthesized from the oil extracted from source 2. Thermogravimetric analysis demonstrated enhanced thermal stability post-oil conversion, highlighting decomposition stages for rigid and flexible segments. Differential scanning calorimetry indicated higher unsaturation in the oil extracted from source 1, resulting in an elevated crystallization temperature. Tensile testing showed increased elasticity as the [NCO]/[OH] ratio decreased in the material, emphasizing the influence of polyol and crosslinking agent concentrations on mechanical resistance of polyurethane materials. sources method 4521 45 21 45.21 1 4032 40 32 40.32 2, 2 , 2) 2870 28 70 28.7 2600 26 00 26.0 respectively 7987 79 87 79.8 6711 67 11 67.11 composition (FTIR postoil post conversion segments temperature NCO/OH NCOOH NCO / OH [NCO]/[OH 452 4 45.2 403 3 40.3 287 7 28. 260 0 26. 798 8 79. 671 6 67.1 45. 40. 67.

https://doi.org/10.21577/0103-5053.20240123

Computer-Aided Drug Design Studies in Association with in vitro Antileishmanial Tests for New Chalcones ComputerAided Computer Aided
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Silva, Gleice R. da

; Santos, Francisnaira S.

; Leite, Fernando F.

; Acevedo, Chonny A. H.

; Sousa, Natália F. de

; Grimaldi, Gabriela B.

; Soares, Milena B. P.

; Guimarães, Elisalva T.

; Scotti, Marcus T.

; Rodrigues, Luis Cezar

; Mendonça Júnior, Francisco J. B.

; Campana, Eloísa H.

; Barbosa Filho, José M.

; Guimarães, Hemerson I. F.

; Guerra, Felipe Q. S.

Journal of the Brazilian Chemical Society

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2025, Volume 36 Nº 2 elocation e-20240135

Resumo: En | Texto: En | PDF: En

In silico and in vitro tests can reveal promising anti-leishmania activity for natural products and their derivatives. The aim of this study was to investigate in silico the pharmacological activities of potential new chalcones and their leishmanicidal potential in vitro. The in silico study was carried out using the PASS, MolPredictX and Molegro Virtual Docker 6.0 programs. Antiparasitic activity was assessed in axenic promastigote and amastigote forms of Leishmania braziliensis. The cytotoxicity tests used the J77G8 cell line. The chalcones exhibited 50% cytotoxic concentration values (CC50) values > 50 μM. Chalcone 4 (named FERAI) presented the best activity with concentration for 50% of promastigotes and intracellular parasites forms (EC50) of 9.75 ± 1.7 and 10.13 ± 1.7 μM for promastigote and amastigote, respectively. Reactive oxygen species (ROS) testing presented increased ROS levels in the parasite at the FERAI concentrations of 10 μM (56.33%), 20 μM (61.76%) and 30 μM (67.13%). Molecular docking revealed interactions (binding energy) between FERAI and the enzymes UDP-glycosyl pyrophosphorylase (-56.8384), dihydroorotate-dehydrogenase (-132.276) and trypanothione-reductase (-151.281). Our results demonstrated the anti-leishmanial activity of chalcones, especially FERAI, with a noted raising of ROS levels in the parasite. Molecular docking revealed dihydroorotate dehydrogenase and trypanothione reductase as potential pharmacological targets for FERAI. antileishmania anti leishmania derivatives PASS 60 6 0 6. programs braziliensis JG J G J77G line CC50 CC (CC50 5 named EC50 EC (EC50 975 9 75 9.7 17 1 7 1. 1013 13 10.1 respectively (ROS 56.33%, 5633 56.33% , 56 33 (56.33%) 2 61.76% 6176 61 76 (61.76% 3 67.13%. 6713 67.13% . 67 (67.13%) binding energy UDPglycosyl UDP glycosyl 56.8384, 568384 56.8384 8384 (-56.8384) dihydroorotatedehydrogenase 132.276 132276 132 276 (-132.276 trypanothionereductase 151.281. 151281 151.281 151 281 (-151.281) antileishmanial leishmanial CC5 (CC5 EC5 (EC5 97 9. 101 10. 563 56.33 (56.33% 61.76 617 (61.76 671 67.13 (67.13% 56838 56.838 838 (-56.8384 132.27 13227 27 (-132.27 15128 151.28 15 28 (-151.281 (CC (EC 56.3 (56.33 61.7 (61.7 67.1 (67.13 5683 56.83 83 (-56.838 132.2 1322 (-132.2 1512 151.2 (-151.28 56. (56.3 61. (61. 67. (67.1 568 56.8 8 (-56.83 132. (-132. 151. (-151.2 (56. (61 (67. (-56.8 (-132 (-151. (56 (6 (67 (-56. (-13 (-151 (5 ( (-56 (-1 (-15 (-5 (-

https://doi.org/10.21577/0103-5053.20240135

Solid-Liquid Extraction with Low-Temperature Partitioning as an Alternative to Determinate Pesticide Residues in Teas SolidLiquid Solid Liquid LowTemperature Low Temperature
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Teixeira, Aline Maria

; Queiroz, Maria Eliana L. R. de

; Oliveira, André Fernando de

; Rodrigues, Alessandra A. Z.

; Novaes, Fábio Junior M.

; Freitas, Jéssika F. de

; Miranda, Liany D. L.

Journal of the Brazilian Chemical Society

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2025, Volume 36 Nº 3 elocation e-20240165

Resumo: En | Texto: En | PDF: En

Methods used to determine pesticide residues in teas typically require several laborious steps for sample preparation before analysis. In this study, a simple method based on solid-liquid extraction with low-temperature partitioning (SLE/LTP) and analysis by gas chromatography coupled to mass spectrometry (GC-MS) was optimized and validated for the determination of pesticide residues (pirimiphos-methyl, flutriafol, cyproconazole, and bifenthrin) in dehydrated green tea leaves. After low-temperature partitioning (LTP), the extract in acetonitrile was subjected to a clean-up step using primary secondary amine (PSA) and octadecylsilane (C18) as sorbents for chlorophyll removal. The optimized SLE/LTP-GC-MS method was validated, and it proved to be effective and selective for extracting pesticides from green tea samples, presenting limit of detection (LOD) and limit of quantification (LOQ) of 0.015 and 0.050 mg kg-1, respectively. Recovery ranged between 81-111%, coefficients of variation were less than 16% and coefficients of determination (R2) were greater than 0.990. The optimized and validated method was applied to green tea and 13 other tea varieties sampled in South and Southeast regions of Brazil. The pesticides under study were detected in some of those samples at values higher than the maximum residue limits (MRLs) allowed by the European Union. solidliquid solid liquid lowtemperature low temperature SLE/LTP SLELTP SLE LTP (SLE/LTP GCMS GC MS (GC-MS pirimiphosmethyl, pirimiphosmethyl pirimiphos methyl, methyl (pirimiphos-methyl flutriafol cyproconazole bifenthrin leaves LTP, , (LTP) cleanup clean up PSA (PSA C18 C (C18 removal SLE/LTPGCMS SLELTPGCMS LOD (LOD LOQ (LOQ 0015 0 015 0.01 0050 050 0.05 kg1, kg1 kg 1, 1 kg-1 respectively 81111%, 81111 81 111%, 111 81-111% 16 R2 R (R2 0990 990 0.990 Brazil MRLs (MRLs Union (LTP C1 (C1 LTPGCMS 001 01 0.0 005 05 kg- 81111% 8111 8 111% 11 81-111 (R 099 99 0.99 (C 00 0. 811 81-11 09 9 0.9 81-1 81-

https://doi.org/10.21577/0103-5053.20240165

Spatial variability of soil and vegetation properties in integrated production systems
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Laurenti, Nicolle

; Pezzopane, José R. M.

; Guimarães, Edilson da S.

; Bernardi, Alberto C. de C.

; Rodrigues, Josiane

Revista Brasileira de Engenharia Agrícola e Ambiental

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Out 2024, Volume 28 Nº 10 elocation e280481

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Os sistemas de produção integrados surgiram como uma estratégia de produção sustentável na intensificação do uso da terra com impacto mínimo nas funções do ecossistema. Este estudo utilizou ferramentas de agricultura de precisão para investigar a variabilidade espacial de propriedades do solo e da vegetação em área de Integração Lavoura-Pecuária-Floresta (ILPF) e área de Integração Pecuária-Floresta (IPF) em São Carlos, SP, Brasil. Consequentemente, foram avaliados: (1) as propriedades físico-químicas do solo, (2) a resistividade elétrica, e (3) os atributos da cultura do Eucalyptus urograndis que compõem a área de estudo. As amostragens foram realizadas em (1) agosto de 2021 nas profundidades de 0-0,2 e 0,2-0,4 m; (2) outubro de 2021 nas profundidades de 0-0,5, 0-1,0 e 0-2,0 m; e (3) abril de 2021 e abril de 2022. Os resultados indicaram que os valores dos parâmetros de fertilidade do solo foram adequados ao desenvolvimento da cultura e apresentaram baixa variabilidade espacial. As análises de solo indicaram baixa acidez, altos teores de matéria orgânica, teores médios de fósforo, potássio e capacidade de troca catiônica e altos teores de cálcio, magnésio e saturação por base. Entretanto, foram observados locais com maior variabilidade espacial para cálcio, refletindo variabilidade na capacidade de troca catiônica e saturação por base. A granulometria e a resistividade elétrica do solo apresentaram baixa variabilidade espacial na camada superficial. Mesmo sem diferenças nas propriedades do solo, houve diferença de 15% no maior volume de madeira no sistema IPF em comparação ao ILPF. ecossistema LavouraPecuáriaFloresta Lavoura Pecuária Floresta ILPF (ILPF PecuáriaFloresta (IPF Carlos SP Brasil Consequentemente avaliados 1 (1 físicoquímicas físico químicas 2 (2 3 (3 202 00,2 002 0 0,2 0-0, 0,20,4 0204 0,4 4 0,2-0, m 00,5, 005 0,5, 5 0-0,5 01,0 010 1,0 0-1, 02,0 020 2,0 0-2, 2022 acidez orgânica fósforo cálcio base Entretanto superficial 15 ( 20 00 00, 02 0, 0-0 0,20, 04 0,2-0 00,5 05 0,5 01 01, 10 1, 0-1 02, 2, 0-2 0- 0,20 0,2-

ABSTRACT Integrated production systems have emerged as a sustainable production strategy in intensifying land use with minimal impact on ecosystem functions. This study used precision agriculture tools to investigate the spatial variability of soil and vegetation properties in an integrated crop-livestock-forestry (ICLF) and in an integrated livestock-forestry (ILF) area of São Carlos city, SP, Brazil. Consequently, the following were assessed: (1) the soil physicochemical properties, (2) the electrical resistivity, and (3) the attributes of the Eucalyptus urograndis crop comprising the study area. Samplings were performed in (1) August 2021 at depths of 0-0.2 and 0.2-0.4 m; (2) October 2021 at depths of 0-0.5, 0-1.0, and 0-2.0 m; and (3) April 2021 and April 2022. Results indicated that the values for soil fertility parameters were suitable for crop development and presented low spatial variability. Soil analyses indicated low acidity, high levels of organic matter, average cation exchange capacity, phosphorus and potassium contents, high base saturation, and calcium and magnesium levels. However, locations with greater spatial variability for calcium were observed, reflecting cation exchange capacity and base saturation variability. Soil granulometry and electrical resistivity had a low spatial variability at the surface layer. Even without differences in the soil properties, there was a difference of 15% in the larger wood volume in the ILF then ICLF system. functions croplivestockforestry livestock forestry (ICLF livestockforestry (ILF city SP Brazil Consequently assessed 1 (1 2 (2 3 (3 202 00.2 002 0 0.2 0-0. 0.20.4 0204 0.4 4 0.2-0. m 00.5, 005 0.5, 5 0-0.5 01.0, 010 1.0, 0-1.0 02.0 020 2.0 0-2. 2022 acidity matter contents However observed layer 15 system ( 20 00 00. 02 0. 0-0 0.20. 04 0.2-0 00.5 05 0.5 01 01.0 10 1.0 0-1. 02. 2. 0-2 0- 0.20 0.2- 01. 1. 0-1

https://doi.org/10.1590/1807-1929/agriambi.v28n10e280481

Inflammatory markers in prepubertal children and their associations with abdominal fat
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Queiroz, Letícia G. de

; Collett-Solberg, Paulo F.

; Souza, Maria das Graças C. de

; Rodrigues, Nádia Cristina P.

; Monteiro, Alexandra M.

; Mendes, Cristiane de S.

; Gazolla, Fernanda M.

; Oliveira, Cecília L. de

; Bouskela, Eliete

; Kuschnir, Maria Cristina C.

; Madeira, Isabel R.

Jornal de Pediatria

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Out 2024, Volume 100 Nº 5 Páginas 544 - 551

Resumo: En | Texto: En | PDF: En

Abstract Objective To evaluate the association between inflammatory markers and abdominal fat assessed by ultrasound in prepubertal children with and without excess weight. Methods A cross-sectional study involving 241 prepubertal children, 156 with obesity, 37 with overweight, and 48 with normal weight, aged five to ten years, who were followed at a research unit on Childhood Obesity from a teaching hospital belonging to a public health system. The concentration of interleukin-6, tumor necrosis factor-α and C-reactive protein were assessed and regression analyses, considering outcome variables such as abdominal wall and intra-abdominal fat thickness measured by ultrasound, were performed. Results The findings highlighted an association between abdominal fat and inflammatory markers, even in children at this young age group. Subcutaneous fat showed a stronger association with inflammatory biomarkers compared to intra-abdominal fat when performing logistic regression, with a positive association between tumor necrosis factor-α and abdominal wall thickness equal to or greater than the 75th percentile in adjusted logistic regression (OR: 18.12; CI 95 %: 1.57: 209.55). Conclusions Abdominal wall fat, in contrast to what is often observed in adults, appears to have a greater impact on chronic inflammation related to excessive weight in very young children. crosssectional cross sectional 24 15 obesity 3 overweight 4 years system interleukin6, interleukin6 interleukin 6, 6 interleukin-6 factorα factor α Creactive C reactive analyses intraabdominal intra performed group th OR (OR 18.12 1812 18 12 9 % 1.57 157 1 57 209.55. 20955 209.55 . 209 55 209.55) adults 2 interleukin- 18.1 181 1.5 5 2095 209.5 20 18. 1. 209.

https://doi.org/10.1016/j.jped.2024.03.015

[SciELO Preprints] - Demographic Profile and Characteristics of Adolescent and Pre-Adolescent Mothers During the COVID-19 Pandemic in the State of Ceará (Brazil)
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Azevedo, Evellyn Moreira de Silva, Nicolas Braga da Alves Santos, João Victor Matias, Ruan Oliveira Rodrigues, Micael da Silva Geraldo, Raul Rodrigues Mesquita de Lima, Riquelme Gabriel Santos, Gustavo Pires dos Oliveira Macedo, Pedro Nicolas Cândido Sobrinho, Silvio Alencar

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Data de publicação: 2024-08-23

Resumo: Pt Es En

A gravidez na adolescência é um problema significativo de saúde pública no Brasil, contribuindo para altas taxas de morbimortalidade entre mulheres jovens. Durante a gestação, muitas adolescentes abandonam a escola e o trabalho, o que resulta em menor qualificação e maior vulnerabilidade ao mercado de trabalho informal. Além disso, as adolescentes grávidas enfrentam riscos elevados de complicações gestacionais e desafios emocionais, como ansiedade e depressão. A pandemia exacerbou essas vulnerabilidades, especialmente em relação ao abuso doméstico, devido ao isolamento social. Este estudo justifica-se pela necessidade de compreender o perfil demográfico e as características das parturientes adolescentes no Ceará entre 2020 e 2022, oferecendo subsídios para políticas públicas que visem melhorar a qualidade de vida dessas jovens e de seus filhos. Todos os dados foram analisados utilizando R. Durante o período analisado, foram registrados 331.924 nascimentos vivos no Ceará, dos quais 21.667 (6,53%) eram de mães com idade igual ou inferior a 17 anos. A idade média das mães adolescentes foi de 15,93 ± 1,11 anos, enquanto a média para as mães adultas foi de 28,00 ± 6,21 anos, evidenciando uma diferença estatisticamente significativa (Teste-t de Student, P < 0,05). A análise também revelou uma diferença significativa entre a idade dos pais de crianças nascidas de mães adolescentes (22,25 ± 5,72 anos) em comparação à idade dos pais de crianças nascidas de mães adultas (32,45 ± 7,81 anos) (Figura 3, Teste-T, P < 0,05). No que se refere à etnia, adolescentes indígenas representaram 9,95% dos casos de gravidez, seguidas pelas adolescentes pardas (7,26%) e pretas (5,9%). A menor proporção foi observada entre adolescentes brancas (4,43%). Não houve diferença estatisticamente significativa entre os grupos indígenas, pardas, pretas e a população amarela. Quanto ao estado civil, 71% das adolescentes se declararam solteiras. A análise educacional demonstrou uma tendência significativa de gravidez entre adolescentes com Ensino Fundamental II incompleto, completo, ou Ensino Médio incompleto, indicando que essas jovens ainda estavam em fase de conclusão desses ciclos escolares. Não foi observada uma relação significativa entre a redução da idade materna e a diminuição do escore APGAR em recém-nascidos (APGAR = 0,014 × “IDADE DA MÃE” + 8,5; P < 0,05, R² = 0,0004). Além disso, não houve diferença significativa na proporção de anomalias congênitas entre os nascimentos de mães adolescentes e adultas.

El embarazo en la adolescencia es un problema significativo de salud pública en Brasil, que contribuye a altas tasas de morbimortalidad entre las mujeres jóvenes. Durante el embarazo, muchas adolescentes abandonan la escuela y el trabajo, lo que resulta en menor calificación y mayor vulnerabilidad en el mercado laboral informal. Además, las adolescentes embarazadas enfrentan mayores riesgos de complicaciones gestacionales y desafíos emocionales, como ansiedad y depresión. La pandemia exacerbó estas vulnerabilidades, especialmente en relación con el abuso doméstico, debido al aislamiento social. Este estudio se justifica por la necesidad de comprender el perfil demográfico y las características de las madres adolescentes en Ceará entre 2020 y 2022, ofreciendo apoyo para políticas públicas que busquen mejorar la calidad de vida de estas jóvenes y sus hijos. Todos los datos fueron analizados utilizando R. Durante el período analizado, se registraron 331.924 nacimientos vivos en Ceará, de los cuales 21.667 (6,53%) eran de madres de 17 años o menos. La edad promedio de las madres adolescentes fue de 15,93 ± 1,11 años, mientras que la media para las madres adultas fue de 28,00 ± 6,21 años, evidenciando una diferencia estadísticamente significativa (Prueba t de Student, P < 0,05). El análisis también reveló una diferencia significativa entre la edad de los padres de niños nacidos de madres adolescentes (22,25 ± 5,72 años) en comparación con la edad de los padres de niños nacidos de madres adultas (32,45 ± 7,81 años) (Prueba de Wilcoxon, P < 0,05). En cuanto a la etnia, las adolescentes indígenas representaron el 9,95% de los casos de embarazo, seguidas por las adolescentes mestizas (7,26%) y negras (5,9%). La menor proporción se observó entre las adolescentes blancas (4,43%). No hubo diferencia estadísticamente significativa entre los grupos indígenas, mestizas, negras y la población amarilla. En cuanto al estado civil, el 71% de las adolescentes se declararon solteras. El análisis educativo demostró una tendencia significativa de embarazo entre adolescentes con secundaria incompleta o completa, o educación media incompleta, lo que indica que estas jóvenes aún estaban en proceso de completar estos niveles educativos. No se observó una relación significativa entre la disminución de la edad materna y la reducción de la puntuación APGAR en los recién nacidos (APGAR = 0,014 × "EDAD DE LA MADRE" + 8,5; P < 0,05, R² = 0,0004). Además, no hubo diferencia significativa en la proporción de anomalías congénitas entre los nacimientos de madres adolescentes y adultas.

Adolescent pregnancy is a significant public health issue in Brazil, contributing to high morbidity and mortality rates among young women. During pregnancy, many adolescents drop out of school and work, leading to lower qualifications and increased vulnerability to the informal labor market. Moreover, pregnant adolescents face higher risks of gestational complications and emotional challenges, such as anxiety and depression. The pandemic exacerbated these vulnerabilities, particularly concerning domestic abuse, due to social isolation. This study is justified by the need to understand the demographic profile and characteristics of adolescent mothers in Ceará between 2020 and 2022, providing support for public policies aimed at improving the quality of life for these young women and their children. All data were analyzed using R. During the analyzed period, 331,924 live births were recorded in Ceará, of which 21,667 (6.53%) were from mothers aged 17 years or younger. The average age of adolescent mothers was 15.93 ± 1.11 years, while the average for adult mothers was 28.00 ± 6.21 years, showing a statistically significant difference (Student's t-test, P < 0.05). The analysis also revealed a significant difference between the age of fathers of children born to adolescent mothers (22.25 ± 5.72 years) compared to the age of fathers of children born to adult mothers (32.45 ± 7.81 years) (Wicoxon test, P < 0.05). Regarding ethnicity, indigenous adolescents accounted for 9.95% of pregnancy cases, followed by brown (7.26%) and black (5.9%) adolescents. The lowest proportion was observed among white adolescents (4.43%). There was no statistically significant difference among indigenous, mixed-race, black, and yellow populations. Concerning marital status, 71% of adolescents declared themselves single. Educational analysis showed a significant trend of pregnancy among adolescents with incomplete or complete middle school or incomplete high school education, indicating that these young women were still in the process of completing these educational levels. There was no significant relationship between decreasing maternal age and a reduction in newborns' APGAR scores (APGAR = 0.014 × "MOTHER'S AGE" + 8.5; P < 0.05, R² = 0.0004). Additionally, there was no significant difference in the proportion of congenital anomalies between births of adolescent and adult mothers.

https://doi.org/10.1590/SciELOPreprints.9645

Skin microbiome in diabetes mellitus: a literature review
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Rodrigues, Sofia R.

; Mottola, Carla

; Costa, João Borges-da

Portuguese Journal of Dermatology and Venereology

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Jun 2024, Volume 82 Nº 2 Páginas 95 - 98

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The authors performed a review to investigate if there are alterations in the skin microbiome among individuals with diabetes mellitus (DM) and to assess how these alterations may contribute to specific skin conditions and complications associated with this disease. On December 1st, 2023, searches on the PubMed® and ScienceDirect databases were conducted, using the Mesh Terms “skin microbiome” AND “DM”, limiting the results to those published in the last 10 years. The authors identified seven articles, including two reviews and five original research papers. Both type of papers revealed that individuals with DM exhibited significant less diversity in terms of microbial richness, with a notable colonization by Staphylococcus spp. In conclusion, the skin microbiome appears to be impaired in individuals with DM. However, more longitudinal studies are necessary to determine whether this impairment is a consequence of DM and to understand how it may interfere with DM complications.

Resumo Os autores pretendem esclarecer se existem alterações no microbioma cutâneo em pessoas com Diabetes Mellitus (DM), passíveis de predispor a patologia cutânea e complicações desta doença. As bases de dados PubMed® e ScienceDirect foram pesquisadas a 1 de dezembro de 2023, utilizando os Mesh Terms “skin microbiome” AND “diabetes mellitus”, limitando os resultados aos artigos publicados nos últimos 10 anos. Obtiveram-se 7 artigos, incluindo 2 revisões e 5 artigos de investigação original. Ambos os tipos de artigos revelaram que a pele das pessoas com DM apresenta uma diversidade microbiana significativamente menor, com uma forte colonização de Staphylococcus spp. Em conclusão, o microbioma da pele parece estar alterado nos indivíduos com DM Contudo, são necessários mais estudos longitudinais para compreender se esse comprometimento é consequência da DM e como pode interferir nas complicações da doença.

https://doi.org/10.24875/pjdv.24000011

Canonical correlation between clogging agents and performance of drippers operating with aquaculture effluents
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Paiva, Laio A. L. de

; Batista, Rafael O.

; Silva, Rodrigo R. da

; Moniz, Tiago D. da C.

; Augusto, Francisco I. S.

; Cunha, Weverton A. da

; Rodrigues Filho, Ricardo A.

; Melo, Stefeson B. de

; Costa, Lucas R. da

; Medeiros, José F. de

; Portela, Jeane C.

; Araújo, Antonio G. R.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Mai 2024, Volume 28 Nº 5 elocation e274127

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT The canonical correlation is used to correlate groups of distinct variables. The objective of this study was to use canonical correlation analysis to evaluate the interaction between water quality attributes clogging-causing and the hydraulic performance of non-pressure compensating drippers operating with dilutions of aquaculture effluent in well water. The experiment was in a completely randomized design in a split-split-plot scheme with three replicates, with five dilutions in the plots (Dilution 1: 100% aquaculture effluent; Dilution 2: 75% aquaculture effluent + 25% well water; Dilution 3: 50% aquaculture effluent + 50% well water; Dilution 4: 25% aquaculture effluent + 75% well water; and Dilution 5: 100% well water), three emitters in the sub-plots (ST (1.6 L h-1), SL (1.6 L h-1) and NJ (1.7 L h-1)), and three operating times in the sub-subplots (0, 80 and 160 hours, in which 0 hours operating time means the start of evaluations). The statistical analyses performed were correlation matrix and canonical analysis. The canonical correlation analysis indicated that when the concentrations of attributes increase, the hydraulic performance of the drippers decreases. The interaction of this group of attributes indicates that the clogging of drippers operating with the five dilutions of aquaculture effluent in well water occurs by the combined action of physical, chemical, and biological agents. The ST dripper was the least sensitive to the group of quality attributes of the dilutions, whereas the most sensitive was the SL dripper. variables cloggingcausing causing nonpressure non pressure splitsplitplot split plot replicates 1 100 2 75 25 3 50 4 5 water, , water) subplots sub 1.6 16 6 (1. h1, h1 h h-1 1.7 17 7 h-1)) subsubplots 0, (0 8 evaluations. evaluations . evaluations) increase decreases physical chemical agents 10 1. (1 h- (

RESUMO A correlação canônica é usada para correlacionar grupos de variáveis distintas. O objetivo deste estudo foi utilizar análise de correlação canônica para avaliar a interação entre atributos de qualidade da água causadores de entupimento e o desempenho hidráulico de gotejadores não autocompensantes operando com diluições de efluente de aquicultura em água de poço. O experimento foi conduzido em delineamento inteiramente casualizado, em esquema de parcelas subsubdivididas, com três repetições, com cinco diluições nas parcelas (Diluição 1: 100% de efluente de aquicultura; Diluição 2: 75% de efluente de aquicultura + 25% de água de poço; Diluição 3 : 50% efluente de aquicultura + 50% água de poço; Diluição 4: 25% efluente de aquicultura + 75% água de poço; e Diluição 5: 100% água de poço), três emissores nas subparcelas (ST (1,6 L h-1) , SL (1,6 L h-1) e NJ (1,7 L h-1)), e três tempos de operação nas subsubparcelas (início do experimento, 80 e 160 horas, em que 0 horas de operação significa o início das avaliações). As análises estatísticas realizadas foram matriz de correlação e análise canônica. A análise de correlação canônica indicou que quando as concentrações dos atributos aumentam, o desempenho hidráulico dos gotejadores diminui. A interação desse grupo de atributos indica que o entupimento dos gotejadores que operam com as cinco diluições de efluente de aquicultura em água de poço ocorre pela ação combinada de agentes físicos, químicos e biológicos. O gotejador ST foi o menos sensível ao grupo de atributos de qualidade das diluições, enquanto o mais sensível foi o gotejador SL. distintas casualizado subsubdivididas repetições 1 100 2 75 25 50 4 5 poço, poço) 1,6 16 6 (1, h1 h h-1 1,7 17 7 h1, h-1)) 8 avaliações. avaliações . avaliações) aumentam diminui físicos biológicos 10 1, (1 h- (

https://doi.org/10.1590/1807-1929/agriambi.v28n5e274127

Bioestimulant with Ascophyllum nodosum and fulvic acids as mitigating factors of salinity damage in soybean
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Silva, Bruna A. da

; Silva, Johny de S.

; Silva, Toshik I. da

; Costa, Rafael S. da

; Castro, Carolina S. de

; Oliveira, Letícia K. B. de

; Sousa, Tomil R. M. de

; Rodrigues, Carlos Y. A. C.

; Cardoso, Flávio B.

; Mesquita, Rosilene O.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Abr 2024, Volume 28 Nº 4 elocation e278961

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Soil salinization negatively affects the growth and yield of economically valuable crops such as soybeans. New technologies are being developed to minimize the damage caused by saline stress and improve crop performance. Therefore, the use of biostimulants in agriculture may offer an alternative method to mitigate the deleterious effects of salinity. Extracts of the seaweed, Ascophyllum nodosum and humic substances (fulvic acids) are commonly used. Therefore, this study aimed to evaluate the action of a biostimulant composed of A. nodosum seaweed extract and fulvic acid applied at different phenological stages on the biometric, biochemical, and physiological parameters of soybeans (Glycine max) subjected to irrigation with saline water. The experimental design used was completely randomized in a 3 × 2 + 2 factorial scheme, referring to three applications of the biostimulant at different soybean phenological stages: V3, V3R1, and V3R1R4, two levels of electrical conductivity of irrigation water (ECw): 0.5 (S0) and 5.0 dS m-1 (S1), two additional controls, one with a positive control (PC) and the other with a negative control (NC). The experiment had five replicates with one plant per plot. The results of this study suggest that the application of the biostimulant can mitigate the harmful effects of salt stress in soybeans. The results obtained with V3R1 application in the parameters stem diameter, leaf area, shoot dry mass, electrolyte leakage, and chlorophyll b represent greater efficiency in mitigating the harmful effects of salinity in soybean cultivation. performance Therefore acids A biometric biochemical Glycine max scheme V3 V VR R V3R1R4 VRR ECw (ECw) 05 0 5 0. S0 S (S0 50 5. m1 m 1 m- S1, S1 , (S1) controls PC (PC NC. NC . (NC) plot V3R diameter area mass leakage cultivation V3R1R (ECw (S (S1 (NC

RESUMO Processo de salinização do solo afeta negativamente o crescimento e o rendimento de culturas economicamente valiosas, como a soja. Com o objetivo de minimizar os danos causados pelo estresse salino e melhorar o desempenho das culturas, novas tecnologias estão sendo desenvolvidas. Neste contexto, o uso de bioestimulantes na agricultura pode oferecer uma alternativa para mitigar os efeitos deletérios da salinidade. O extrato da alga Ascophyllum nodosum e substâncias húmicas (ácidos fúlvicos) são comumente empregados. Portanto, o estudo teve como objetivo avaliar a ação de um bioestimulante composto pelo extrato da alga marinha A. nodosum e ácidos fúlvicos aplicados em diferentes estádios fenológicos sobre parâmetros biométricos, bioquímicos e fisiológicos da soja (Glycine max) submetida à irrigação com água salina. O delineamento experimental utilizado foi inteiramente casualizado em esquema fatorial 3 x 2 + 2, referente a três aplicações do bioestimulante em diferentes estádios fenológicos da soja: V3, V3R1 e V3R1R4, dois níveis de condutividade elétrica da água de irrigação (CEa): 0,5 (S0) e 5,0 dS m-1 (S1), dois controles adicionais, um com controle positivo (PC) e outro com controle negativo (NC). O experimento contou com cinco repetições e uma planta por parcela. Os resultados deste estudo sugerem que a aplicação do bioestimulante pode ser uma alternativa na mitigação dos efeitos nocivos do estresse salino em soja. Os resultados foram obtidos com a aplicação V3R1 nos parâmetros diâmetro do caule, área foliar, massa seca da parte aérea, extravasamento de eletrólitos e clorofila b representam maior eficiência na mitigação dos efeitos nocivos da salinidade no cultivo da soja. valiosas desenvolvidas contexto empregados Portanto A biométricos Glycine max salina V3 V VR R V3R V3R1R4 VRR CEa (CEa) 05 0 5 0, S0 S (S0 50 5, m1 m 1 m- S1, S1 , (S1) adicionais PC (PC NC. NC . (NC) parcela caule foliar aérea V3R1R (CEa (S (S1 (NC

https://doi.org/10.1590/1807-1929/agriambi.v28n4e278961

10.

Chemical control associated with genetic management of Meloidogyne javanica in soybean
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Fontanela, Maira Laíza C.

; Miamoto, Angélica

; Rodrigues-Neto, Durvalino Augusto

; Calandrelli, Angélica

; Silva, Monique Thiara R. e

; Dias-Arieira, Cláudia Regina

Chilean journal of agricultural research

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Fev 2024, Volume 84 Nº 2 Páginas 281 - 290

Resumo: En | Texto: En | PDF: En

ABSTRACT Integrated management is considered the best strategy to mitigate the damage caused by plant-parasitic nematodes. However, there is still limited information regarding some integrated techniques. Thus, this study aimed to assess the effects of genetic management associated with chemical control of Meloidogyne javanica in soybean (Glycine max (L.) Merr.) The experiment was installed in a greenhouse according to an 8×4 factorial design with eight replicates. The first factor was soybean cultivar (HO Juruena IPRO, resistant; Foco IPRO, HO Maracaí IPRO, and CZ 58B28 IPRO, moderately resistant; HO Mamoré IPRO, moderately susceptible; and Extrema IPRO, CZ 48B32 IPRO, and HO Aporé IPRO, susceptible). The second factor consisted of an untreated control and commercial nematicides based on abamectin, thiodicarb+imidacloprid, and fluopyram. Plants were inoculated with 2000 nematode eggs, and nematode and vegetative variables were evaluated at 65 d after inoculation. There was an interaction effect on nematode variables. Furthermore, there was an additive effect of genetic management and chemical control, mainly in resistant cultivars treated with thiodicarb+imidacloprid or fluopyram with controls of up to 69.90% and 96.86%, respectively. The application of fluopyram and the use of ‘HO Juruena IPRO’, ‘Foco IPRO’, or ‘HO Maracaí IPRO’ also contributed to the control of M. javanica. Vegetative variables were studied by analyzing product effects separately, but results were inconclusive.

https://doi.org/10.4067/s0718-5839202400020028

11.

Amidines: The Main Discoveries in the Synthesis and Anti-Leishmanial Effects of New Chemotherapeutic Agents Amidines AntiLeishmanial Anti Leishmanial
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Rodrigues-Santos, Cláudio E.

; Brito, Maurício R. de

; Echevarria, Aurea

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 10 elocation e-20240053

Resumo: En | Texto: En | PDF: En

Leishmaniasis is an infectious disease caused by protozoan parasites of the Leishmania genus and affects more than 90 countries, especially in tropical and subtropical regions. The first treatment for these diseases involves pentavalent antimonial derivatives, which are very toxic and cause severe side effects. The other chemotherapeutic drugs used as second-line agents include different organic compound classes, such as pentamidine, which also cause severe side effects. Thus, new, safer, and efficient antileishmaniasis agents are urgently needed to control and treat these diseases. This mini review, which considered the last two decades of related research, highlighted the principal synthetic methodologies used to access amidine derivatives, focusing on more eco-friendly methods. Furthermore, the results obtained from evaluations of the anti-Leishmania activity and several molecular targets of the amidine derivatives are highlighted. 9 countries regions effects secondline second line classes pentamidine Thus new safer review research ecofriendly eco friendly methods Furthermore antiLeishmania anti

https://doi.org/10.21577/0103-5053.20240053

12.

Exploring Urease Inhibition by Coumarin Derivatives through in silico and in vitro Methods
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Fabris, Marciéli

; Camargo, Priscila G.

; Silva, Mariana L.

; Silva, Talis U.

; Machado, Sérgio P.

; Rodrigues, Carlos R.

; Lima, Camilo H. S.

; Albuquerque, Magaly G.

; Bispo, Marcelle L. F.

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 4 elocation e-20230151

Resumo: En | Texto: En | PDF: En

In this report, we designed and synthesized ten N-(R-phenyl)-3-carboxamide-coumarin derivatives (2a-2j), exploring the coumarin nucleus, and an R-phenyl group as a structural scaffold and a peptide bond as a linker between them. The structure-activity relationships were investigated with different R-substituents (H, Br, NO2, Cl) in ortho, meta, or para positions from the phenyl group. Coumarins were obtained in good yields (72-95%), and in vitro screening against Canavalia ensiformis urease showed potential inhibitory percentages ranging from 42 to 65%. Half-maximal inhibitory concentration (IC50) values were determined for the best compounds 2b (R = 2-Br) and 2d (R = 4-Br). After conducting molecular docking and molecular dynamics on urease from C. ensiformis and Helicobacter pylori, potential binding modes for the most effective compounds 2b and 2d showed that these derivatives are able to interact with the crucial residue Cys592, thereby blocking the access of the urea substrate to the active site. According to density functional theory (DFT) calculations, 4-Br substitution on H. pylori urease was necessary for interacting with catalytic amino acids on the active site. report NRphenyl3carboxamidecoumarin NRphenylcarboxamidecoumarin N R 3 carboxamide 2a2j, 2a2j aj 2a 2j , j (2a-2j) nucleus Rphenyl them structureactivity structure activity Rsubstituents substituents H, H (H Br NO2 NO Cl ortho meta 7295%, 7295 72 95% 95 (72-95%) 4 65 65% Halfmaximal Half maximal IC50 IC (IC50 b 2Br 2 2-Br d 4Br. 4Br . 4-Br) C Cys592 Cys site DFT (DFT calculations NRphenyl carboxamidecoumarin (2a-2j 7295% 729 7 9 (72-95% 6 IC5 (IC5 Cys59 (72-95 (IC Cys5 (72-9 (72- (72 (7 (

https://doi.org/10.21577/0103-5053.20230151

13.

Adequação do Consumo de Ácidos Graxos entre Pacientes em Prevenção Cardiovascular Secundária
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Marcadenti, Aline

; Machado, Rachel H. Vieira

; Santos, Renato Hideo Nakagawa

; Kasai, Caio Cesar dos Santos

; Kovacs, Cristiane

; Bello, Annie

; de Matos, Cristina H.

; Bertacco, Renata Torres Abib

; Souza, Gabriela C.

; Schirmann, Gabriela da S.

; Nagano, Francisca Eugenia Zaina

; Poloni, Soraia

; Kik, Raquel Milani El

; Feres, Naoel Hassan

; Rodrigues, Isa G.

; Sousa, Antônio Carlos Sobral

; Pinheiro, Josilene M. F.

; Vasconcelos, Sandra Mary Lima

; Carlos, Daniele Maria de Oliveira

; Souza, Viviane Sahade

; Gomes, Adriana Barros

; Figueiredo Neto, José Albuquerque de

; Moriguchi, Emilio Hideyuki

; Izar, Maria Cristina

; Pinto, Sônia Lopes

; Bressan, Josefina

; de Souza, Simone Raimondi

; Kumbier, Magali C.

; de Araújo, Celme Barroncas Passos

; Torreglosa, Camila R.

; Weber, Bernardete

; Bersch-Ferreira, Ângela Cristine

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 3 elocation e20230487

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Background: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases. Objective: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence. Methods: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial". Dietary intake and cardiovascular risk factors were assessed. Adequate intake of polyunsaturated fatty acids (PUFA) was considered as ≥10% of total daily energy intake; for monounsaturated fatty acids (MUFA), 20%; and for saturated fatty acids (SFA), <7% according to the Brazilian Society of Cardiology. A significance level of 5% was considered in the statistical analysis. Results: No participant adhered to all recommendations simultaneously, and more than half (1,482 [62.9%]) did not adhere to any recommendation. Adherence exclusively to the SFA recommendation was the most prevalent, fulfilled by 659 (28%) participants, followed by adherence exclusively to the PUFA (178 [7.6%]) and MUFA (5 [0.2%]) recommendations. There was no association between the number of comorbidities and adherence to nutritional recommendations (p = 0.269). Participants from the Brazilian Northeast region showed a higher proportion of adherence to SFA consumption recommendations (38.42%) and lower adherence to PUFA intake (3.52%) (p <0.001) compared to other regions. Conclusions: Among the evaluated sample, there was low adherence to nutritional recommendations for dietary fatty acid consumption. Background Objective Methods Crosssectional Cross sectional 2358 2 358 2,35 Trial. Trial . Trial" assessed (PUFA 10 ≥10 MUFA, , (MUFA) 20% 20 SFA, (SFA) 7 <7 Cardiology 5 analysis Results simultaneously 1,482 1482 1 482 (1,48 62.9% 629 62 9 [62.9%] prevalent 65 28% 28 (28% 178 (17 7.6% 76 6 [7.6%] ( 0.2% 02 0 [0.2%] p 0.269. 0269 0.269 269 0.269) 38.42% 3842 38 42 (38.42% 3.52% 352 3 52 (3.52% <0.001 0001 001 regions Conclusions sample 235 35 2,3 ≥1 (MUFA (SFA < 1,48 148 48 (1,4 62.9 [62.9% (28 17 (1 7.6 [7.6% 0.2 [0.2% 026 0.26 26 38.42 384 4 (38.42 3.52 (3.52 <0.00 000 00 23 2, ≥ 1,4 14 (1, 62. [62.9 (2 7. [7.6 0. [0.2 38.4 (38.4 3.5 (3.5 <0.0 1, [62. [7. [0. 38. (38. 3. (3. <0. [62 [7 [0 (38 (3 <0 [6 [

Resumo Fundamento: A adesão à uma alimentação adequada em macronutrientes é fundamental para a prevenção secundária de doenças cardiovasculares. Objetivo: Avaliar a prevalência de adesão às recomendações de consumo de ácidos graxos para prevenção e tratamento de doenças cardiovasculares, e estimar se a presença de determinados fatores de risco cardiovascular estaria associada à adesão. Métodos: Estudo transversal com os dados de linha de base de 2358 participantes do estudo "Brazilian Cardioprotective Nutritional Program Trial". Dados de consumo alimentar, e fatores de risco cardiovascular foram avaliados. Foi considerada, de acordo com a Sociedade Brasileira de Cardiologia, uma ingestão adequada de ácidos graxos poli-insaturados (AGPI) ≥10% do consumo total de energia diária, para ácidos graxos monoinsaturados (AGM), 20% e para ácidos graxos saturados (AGS), <7%. Na análise estatística foi considerando nível de significância de 5%. Resultados: Nenhum participante aderiu a todas as recomendações de forma simultânea e mais da metade (1482 [62,9%]) não aderiu a nenhuma recomendação. A adesão exclusivamente à recomendação de AGS foi a mais prevalente, sendo cumprida por 659 (28%) dos participantes, seguida da adesão exclusivamente à recomendação de AGP (178 [7,6%]) e de AGM (5 [0,2%]). Não houve associação entre o número de comorbidades e a adesão às recomendações nutricionais (p =0,269). Os participantes da região Nordeste do país apresentaram maior proporção de adesão às recomendações para consumo de AGS (38,42%), e menor para ingestão de AGPI (3,52%) (p <0,001) em comparação às demais. Conclusões: Na amostra avaliada, evidenciou-se baixa adesão às recomendações nutricionais para consumo de ácidos graxos. Fundamento cardiovasculares Objetivo Métodos 235 Brazilian Trial. Trial . Trial" alimentar avaliados considerada Cardiologia poliinsaturados poli insaturados (AGPI 10 ≥10 diária AGM, , (AGM) 20 AGS, (AGS) 7 <7% 5 5% Resultados 1482 (148 62,9% 629 62 9 [62,9%] prevalente 65 28% 28 (28% 178 (17 7,6% 76 6 [7,6%] ( 0,2%. 02 0,2% 0 2 [0,2%]) p =0,269. 0269 =0,269 269 =0,269) 38,42%, 3842 38,42% 38 42 (38,42%) 3,52% 352 3 52 (3,52% <0,001 0001 001 demais Conclusões avaliada evidenciouse evidenciou 23 1 ≥1 (AGM (AGS <7 148 (14 62,9 [62,9% (28 17 (1 7,6 [7,6% 0,2 [0,2%] 026 =0,26 26 384 38,42 4 (38,42% 3,52 35 (3,52 <0,00 000 00 ≥ < 14 62, [62,9 (2 7, [7,6 0, [0,2% =0,2 38,4 (38,42 3,5 (3,5 <0,0 [62, [7, [0,2 =0, 38, (38,4 3, (3, <0, [62 [7 [0, =0 (38, (3 <0 [6 [ [0 = (38

https://doi.org/10.36660/abc.20230487

14.

Effectiveness of HoofCare® in the treatment of digital dermatitis in dairy cows HoofCare
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Mendonça, A.P.A.

; Teodoro, P.H.M.

; Silva, J.R.B.

; Moura, R.B.R.

; Ravetti, R.

; Rodrigues, C.A.

Arquivo Brasileiro de Medicina Veterinária e Zootecnia

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2024, Volume 76 Nº 3 elocation e13006

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT This study aimed to determine the effectiveness of topical HoofCare® in the treatment of digital dermatitis (DD) in dairy cows. Thirty-six high-yielding Holstein cows with DD in at least one limb were included and randomly divided into two groups, making 42 limbs. The alternating treatment group consisted of 21 limbs treated for three alternating days every 48h, and the continuous treatment group consisted of 21 limbs treated every 24h for five days. The cows underwent lameness examination, thermographic analysis, and qualitative and quantitative analysis of the lesions on D0 (time of identification of the lesion and prior to treatment), D4 (fourth day of treatment), and D10 (five days after the end of treatment). The data were compared between different time points and groups. There was no significant difference between the groups for the variables evaluated. However, both groups presented a reduction in the degree of lameness around the lesion, in the local temperature, and regression from the active to the inactive stage of the lesions. Thus, this short-term study demonstrates the suggestive efficacy of HoofCare® in treating DD and recommends conducting further long-term studies. HoofCare (DD Thirtysix Thirty six highyielding high yielding 4 2 48h h examination D treatment, , treatment) fourth D1 treatment. . evaluated However temperature Thus shortterm short term longterm long studies

RESUMO Este estudo teve como objetivo determinar a eficácia do HoofCare® tópico no tratamento da dermatite digital (DD) em vacas leiteiras. Trinta e seis vacas Holandesas de alto rendimento, com DD em pelo menos um dos membros, foram incluídas e divididas aleatoriamente em dois grupos, totalizando 42 membros. O grupo de tratamento alternado consistiu de 21 membros tratados por três dias alternados, a cada 48 horas, e o grupo de tratamento contínuo consistiu de 21 membros tratados a cada 24 horas, por cinco dias. As vacas foram submetidas ao exame de claudicação, à análise termográfica, à análise qualitativa e quantitativa das lesões no D0 (momento da identificação da lesão e antes do tratamento), no D4 (quarto dia de tratamento) e no D10 (cinco dias após o término do tratamento). Os dados foram comparados entre diferentes momentos e grupos. Não houve diferença significativa entre os grupos para as variáveis avaliadas. Entretanto, ambos os grupos apresentaram redução no grau de claudicação, na área da lesão, na temperatura local e regressão do estágio ativo para o inativo das lesões. Assim, este estudo de curto prazo demonstra sugestiva eficácia do HoofCare® no tratamento da DD e recomenda a realização de mais estudos de longo prazo. HoofCare (DD leiteiras rendimento 4 2 alternados horas claudicação termográfica D momento tratamento, , quarto D1 tratamento. . avaliadas Entretanto Assim

https://doi.org/10.1590/1678-4162-13006

15.

KINETIC STUDY OF THE REACTION BETWEEN THE CYCLOPALLADATED COMPLEX [PdCl(C2,N-dmba)(tu)] (dmba = N,N-DIMETHYLBENZYLAMINE, tu = THIOUREA) AND L-CYSTEINE PdClC2,Ndmbatu PdClC2Ndmbatu PdClCNdmbatu PdCl C2,N dmba C2 N C [PdCl(C2,N-dmba)(tu) N,NDIMETHYLBENZYLAMINE, NNDIMETHYLBENZYLAMINE N,N DIMETHYLBENZYLAMINE, DIMETHYLBENZYLAMINE N,N-DIMETHYLBENZYLAMINE THIOUREA LCYSTEINE L CYSTEINE PdClC2 Ndmbatu PdClC C2N CN [PdCl(C2,N-dmba)(tu NDIMETHYLBENZYLAMINE N,NDIMETHYLBENZYLAMINE NN
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Félix, Diego B.

; Truzzi, Daniela R.

; Netto, Adelino V. de Godoy

; Soares, Maria Isabella Z.

; Rodrigues, Gian V.

; Pereira, José Clayston M.

Química Nova

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2024, Volume 47 Nº 6 elocation e-20240003

Resumo: En | Texto: En | PDF: En

Cancer is a severe disease that causes a significant number of deaths worldwide every year. Treatments have been available, such as cisplatin, to help combat this disease. However, recent studies have shown that the enzyme system glutathione/glutathione S-transferases (GSH/GST) can cause resistance of tumor cells to this type of cancer treatment. Fortunately, there are alternatives, such as using palladium complexes such as [PdCl(C2,N-dmba)(tu)], which have demonstrated effectiveness against cancer cells. However, even these metallopharmaceuticals can be inhibited by GSH/GST system, which can modify the chemical structure of the complex and prevent it from working as an anticancer agent. That's why it's crucial to study the reaction between the complex [PdCl(C2,N-dmba)(tu)] and L-cysteine using techniques such as NMR, mass spectroscopy, UV-Vis spectroscopy, and stopped-flow. The study of this type of reaction will help researchers understand how these organometallics work in biological systems and how we can improve them to treat cancer more effectively. year available cisplatin However glutathioneglutathione glutathione Stransferases S transferases GSHGST GSH GST (GSH/GST treatment Fortunately alternatives PdClC2,Ndmbatu, PdClC2Ndmbatu PdClCNdmbatu PdCl C2,N dmba tu , C2 N C agent Thats That s its PdClC2,Ndmbatu [PdCl(C2,N-dmba)(tu) Lcysteine L cysteine NMR spectroscopy UVVis UV Vis stoppedflow. stoppedflow stopped flow. flow stopped-flow effectively PdClC2 Ndmbatu PdClC C2N CN [PdCl(C2,N-dmba)(tu

https://doi.org/10.21577/0100-4042.20240003

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