Resumo O estudo analisou a distribuição espacial e as desigualdades sociais na cobertura vacinal para COVID-19 entre crianças de 5 a 11 anos no Brasil. As coberturas vacinais foram calculadas para os municípios brasileiros e analisadas por região geográfica e decis com base no Índice de Desenvolvimento Humano (IDH-M) e expectativa de escolaridade aos 18 anos. Modelos multiníveis foram usados para determinar o coeficiente de partição da variância, e a estatística local bivariada de Moran I foi usada para avaliar a associação espacial. Os resultados mostraram diferenças significativas nas taxas de cobertura vacinal entre os municípios, com menor cobertura nas regiões Norte e Centro-Oeste. Municípios com menor IDH e anos de escolaridade esperados apresentaram menores taxas de cobertura vacinal. A análise de agrupamento bivariado identificou extensas concentrações de municípios nas regiões Norte e Nordeste com baixa cobertura vacinal e baixo desenvolvimento humano, enquanto alguns aglomerados de municípios nas regiões Sudeste e Sul com baixa cobertura localizavam-se em áreas com alto IDH-M. Essas descobertas destacam as desigualdades persistentes em nível municipal na cobertura vacinal entre crianças e a necessidade de intervenções para melhorar o acesso e a cobertura vacinal em áreas mais vulneráveis. COVID19 COVID 19 COVID-1 1 Brasil IDHM M (IDH-M variância CentroOeste. CentroOeste Centro Oeste. Oeste Centro-Oeste humano localizavamse localizavam se IDHM. M. IDH-M vulneráveis COVID1 COVID-

Abstract This study examined the spatial distribution and social inequalities in COVID-19 vaccine coverage among children aged 5-11 in Brazil. First and second dose vaccine coverage was calculated for all Brazilian municipalities and analyzed by geographic region and deciles based on human development index (HDI-M) and expected years of schooling at 18 years of age. Multilevel models were used to determine the variance partition coefficient, and bivariate local Moran’s I statistic was used to assess spatial association. Results showed significant differences in vaccine coverage rates among Brazilian municipalities, with lower coverage in the North and Midwest regions. Municipalities with lower HDI and expected years of schooling had consistently lower vaccine coverage rates. Bivariate clustering analysis identified extensive concentrations of municipalities in the Northern and Northeastern regions with low vaccine coverage and low human development, while some clusters of municipalities in the Southeast and South regions with low coverage were located in areas with high HDI-M. These findings highlight the persistent municipal-level inequalities in vaccine coverage among children in Brazil and the need for targeted interventions to improve vaccine access and coverage in underserved areas. COVID19 COVID 19 COVID-1 511 5 11 5-1 HDIM M (HDI-M 1 age coefficient Morans Moran s association HDIM. M. HDI-M municipallevel municipal level COVID1 COVID- 51 5-

Abstract Understanding the physiological concepts of oxygen delivery is essential to discern the mechanisms that influence its increase, reduction or maintenance in the body. This text explores the different mechanisms that help maintain oxygen delivery even in the face of reduced hemoglobin levels. Adequate oxygen delivery ensures tissue and metabolic balance, which is crucial to avoid harmful consequences such as metabolic acidosis and cellular dysoxia. The complex interaction between variables such as cardiac output, hemoglobin and heart rate (HR) plays a fundamental role in maintaining oxygen delivery, allowing the body to temporarily adjust to situations of anemia or high metabolic demand. It is important to emphasize that blood transfusions should not be based on fixed values, but rather on individual metabolic needs. Strategies to reduce myocardial consumption and monitor macro and micro hemodynamics help in making rational decisions. Individualizing treatment and considering factors such as blood viscosity in relation to the benefits of transfusion are increasingly relevant to optimize therapy and minimize risks, especially in complex clinical scenarios, such as neurocritical patients and trauma victims. increase levels balance dysoxia output HR (HR demand values needs decisions risks scenarios victims

Abstract Anemia is a pathological condition in which the hemoglobin and red blood cell mass decrease; it is mainly defined by the concentration of hemoglobin in the blood. The World Health Organization guidelines establish specific values to define anemia in different population groups. Early detection of anemia can also be a valuable indicator of underlying medical conditions. Clinical studies have explored the relationship between perioperative anemia and morbidity, highlighting the need for more judicious therapeutic strategies, such as the use of Patient Blood Management, which aims to prevent and treat anemia in a personalized and effective way. Patient Blood Management emerges as a promising approach to dealing with anemia, recognizing that its correction through transfusion always carries risks and that personalized prevention and treatment can offer better outcomes for patients. decrease groups conditions morbidity strategies way patients

Abstract This study investigated the association between the IFITM3 rs12252 polymorphism and the severity and mortality of COVID-19 in hospitalized Brazilian patients. A total of 102 COVID-19 patients were included, and the outcomes of interest were defined as death and the need for mechanical ventilation. Genotypes were assessed using Taqman probes. No significant associations were found between the rs12252 polymorphism and COVID-19 outcomes in the original sample, both for death and the need for mechanical ventilation. A meta-analysis, incorporating previous studies that used death as a severity indicator, revealed no association in the allelic and C-recessive models. However, due to the rarity of the T allele and its absence in the sample, further replication studies in larger and more diverse populations are needed to clarify the role of rs12252 in COVID-19 prognosis. IFITM rs rs1225 COVID19 COVID 19 COVID-1 10 included ventilation probes sample metaanalysis, metaanalysis meta analysis, analysis meta-analysis indicator Crecessive C recessive models However prognosis rs122 COVID1 1 COVID- rs12 rs1

Resumo O estudo analisou a distribuição espacial e as desigualdades sociais na cobertura vacinal para COVID-19 entre crianças de 5 a 11 anos no Brasil. As coberturas vacinais foram calculadas para os municípios brasileiros e analisadas por região geográfica e decis com base no Índice de Desenvolvimento Humano (IDH-M) e expectativa de escolaridade aos 18 anos. Modelos multiníveis foram usados para determinar o coeficiente de partição da variância, e a estatística local bivariada de Moran I foi usada para avaliar a associação espacial. Os resultados mostraram diferenças significativas nas taxas de cobertura vacinal entre os municípios, com menor cobertura nas regiões Norte e Centro-Oeste. Municípios com menor IDH e anos de escolaridade esperados apresentaram menores taxas de cobertura vacinal. A análise de agrupamento bivariado identificou extensas concentrações de municípios nas regiões Norte e Nordeste com baixa cobertura vacinal e baixo desenvolvimento humano, enquanto alguns aglomerados de municípios nas regiões Sudeste e Sul com baixa cobertura localizavam-se em áreas com alto IDH-M. Essas descobertas destacam as desigualdades persistentes em nível municipal na cobertura vacinal entre crianças e a necessidade de intervenções para melhorar o acesso e a cobertura vacinal em áreas mais vulneráveis.

Abstract This study examined the spatial distribution and social inequalities in COVID-19 vaccine coverage among children aged 5-11 in Brazil. First and second dose vaccine coverage was calculated for all Brazilian municipalities and analyzed by geographic region and deciles based on human development index (HDI-M) and expected years of schooling at 18 years of age. Multilevel models were used to determine the variance partition coefficient, and bivariate local Moran’s I statistic was used to assess spatial association. Results showed significant differences in vaccine coverage rates among Brazilian municipalities, with lower coverage in the North and Midwest regions. Municipalities with lower HDI and expected years of schooling had consistently lower vaccine coverage rates. Bivariate clustering analysis identified extensive concentrations of municipalities in the Northern and Northeastern regions with low vaccine coverage and low human development, while some clusters of municipalities in the Southeast and South regions with low coverage were located in areas with high HDI-M. These findings highlight the persistent municipal-level inequalities in vaccine coverage among children in Brazil and the need for targeted interventions to improve vaccine access and coverage in underserved areas.

Abstract The pandemic caused an economic, health, and social crisis worldwide, influencing people in different ways. Based on data from 2020 in Brazil, this study analyzed the relative probabilities of white women, black women, and black men being unemployed and working in the informal sector, in the context of the COVID-19 pandemic, compared to white men. For this purpose, a single repeated cross-section was used, derived from PNAD COVID19 data for the months of May, August, and November. The analysis method was the binomial logit, and the results indicate the existence of distinct effects among men, women, black, and white individuals. Both black and white women had a lower probability of being employed compared to white men. However, in the informal employment field, the difference between black men and women and white men was only explained by some observed characteristics that distinguish these groups. economic health worldwide ways 202 Brazil sector COVID 19 COVID-1 purpose crosssection cross section used COVID1 May August November logit individuals However field groups 20 1 COVID- 2

Resumo A pandemia causou uma crise econômica, sanitária e social no mundo inteiro, influenciando as pessoas de diferentes maneiras. O presente trabalho analisou, utilizando dados de 2020 no Brasil, as probabilidades relativas de mulheres brancas, mulheres negras e homens negros, comparativamente a homens brancos, estarem desempregado(a)s e no setor informal, no contexto de pandemia da COVID-19. Para tal, foi utilizada uma única cross-section repetida advinda de dados da PNAD COVID19, para os meses de maio, agosto e novembro. O modelo escolhido para a análise foi o logit binomial. Os resultados encontrados apontam que há efeitos distintos entre homens, mulheres, negros e brancos. As mulheres negras e brancas tiveram menor probabilidade de estarem ocupadas do que homens brancos. Porém, as diferenças nos cargos informais entre mulheres e homens negro(a)s em comparação aos homens brancos foram explicadas somente por características observadas que distinguem esses grupos. econômica inteiro maneiras analisou 202 Brasil desempregadoas desempregado s informal COVID19. COVID19 COVID 19. 19 COVID-19 tal crosssection cross section maio novembro binomial Porém negroas negro grupos 20 COVID1 1 COVID-1 2 COVID-

Abstract Objective The aim of this study was to analyze the effects of fluid overload related to mechanical ventilation, renal replacement therapy, and evolution to discharge or death in critically ill children. Methods A retrospective study in a Pediatric Intensive Care Unit for two years. Patients who required invasive ventilatory support and vasopressor and/or inotropic medications were considered critically ill. Results 70 patients were included. The mean age was 6.8 ± 6 years. There was a tolerable increase in fluid overload during hospitalization, with a median of 2.45% on the first day, 5.10% on the third day, and 8.39% on the tenth day. The median fluid overload on the third day among those patients in pressure support ventilation mode was 4.80% while the median of those who remained on controlled ventilation was 8.45% (p = 0.039). Statistical significance was observed in the correlations between fluid overload measurements on the first, third, and tenth days of hospitalization and the beginning of renal replacement therapy (p = 0.049) and between renal replacement therapy and death (p = 0.01). The median fluid overload was 7.50% in patients who died versus 4.90% in those who did not die on the third day of hospitalization (p = 0.064). There was no statistically significant association between death and the variables sex or age. Conclusions The fluid overload on the third day of hospitalization proved to be a determinant for the clinical outcomes of weaning from mechanical ventilation, initiation of renal replacement therapy, discharge from the intensive care unit, or death among these children. children years andor 7 included 68 8 6. 245 2 45 2.45 510 5 10 5.10 839 39 8.39 480 4 80 4.80 845 8.45 p 0.039. 0039 0.039 . 0 039 0.039) 0.049 0049 049 0.01. 001 0.01 01 0.01) 750 50 7.50 490 90 4.90 0.064. 0064 0.064 064 0.064) unit 24 2.4 51 1 5.1 83 3 8.3 48 4.8 84 8.4 003 0.03 03 0.04 004 04 00 0.0 75 7.5 49 9 4.9 006 0.06 06 2. 5. 8. 4. 0. 7.

Aim This study determined whether COVID-19 fear is correlated with sociodemographic characteristics, general health, mental health, and sleep quality in an elderly Brazilians. Methods Elderly people aged ≥ 60 years replied to an online survey containing questions about their sociodemographic characteristics; general health; levels of stress, anxiety, and depression; sleep quality; and COVID fear. Results Data were statistically analyzed using descriptive statistics (α = 5%). In total, 705 elderly people with mean age of 66 ± 5 years, and most (82.7%) respondents were women, graduated and from southeastern Brazil. COVID-19 fear correlated positively and moderately with sleep quality and symptoms of depression, anxiety, and stress (all p < 0.001). It was associated with females. Elderly people from northern and northeastern Brazil and diabetics had increased COVID-19 fear (all p < 0.05). Conclusion The fear of COVID-19 exists among Brazilian female old people, diabetics, increases anxiety and stress symptoms, and worsen sleep quality in elderly people. COVID19 19 COVID-1 characteristics health Brazilians 6 depression α 5%. 5% . 5%) total 70 82.7% 827 82 7 (82.7% women all 0.001. 0001 0.001 0 001 0.001) females 0.05. 005 0.05 05 0.05) COVID1 1 COVID- 82.7 8 (82.7 000 0.00 00 0.0 82. (82. 0. (82 (8 (

ABSTRACT Objective: to analyze the influence of emotional appeals on behavioral intention regarding organic products for personal care. Theoretical framework: this article uses the literature of emotional appeals, specifically the appeals of guilt, fear, authentic pride, and hubristic pride, to identify their effects on consumers’ behavioral intention in the context of organic personal care products. Emotional appeals of guilt, fear, authentic pride, and hubristic pride were examined. Methodology: four sequential experiments were conducted in real advertisement settings using a within-subjects and between-subjects experimental design. Data were analyzed using ANOVA. Results: the appeal of authentic pride was associated with a heightened value of joy and increased likelihood of consumer donation. The appeal of hubristic pride stimulated an effect of authentic pride. This way, the findings indicate that pride is a one-dimensional emotion in the national context of organic cosmetics consumers. Additionally, the appeal of one-dimensional pride aroused a more positive attitude and purchase intention regarding the advertised product compared to the emotions guilt, fear, and joy. Conclusion: these findings reposition the discussion on pride from a one-dimensional perspective because authentic pride stimulates joy. Further, positive appeals were more effective than negative appeals at increasing the consumers’ behavioral intention toward organic cosmetics. Contrary to the findings of previous surveys, pride was associated with more positive consumer attitudes toward the advertised product. Therefore, the use of pride appeal should be encouraged to promote consumer awareness. Objective framework guilt fear consumers examined Methodology withinsubjects within subjects betweensubjects between design ANOVA Results donation way onedimensional one dimensional Additionally Conclusion Further surveys Therefore awareness

RESUMO Objetivo: analisar a influência de apelos emocionais na intenção comportamental com relação a produtos orgânicos para cuidados pessoais. Marco teórico: utilizou-se a literatura dos apelos emocionais, em específico os apelos de culpa, medo, orgulho autêntico e orgulho hubrístico, para identificar seus efeitos na intenção comportamental no contexto dos produtos orgânicos para cuidados pessoais. Desta forma, utilizaram-se os apelos de culpa, medo, orgulho autêntico e orgulho hubrístico. Metodologia: quatro experimentos sequenciais em configurações de anúncios reais, com desenho experimental (within-subjects e between-subjects), foram realizados. Os dados foram analisados mediante ANOVA. Resultados: o apelo de orgulho autêntico estimulou maior valor de alegria, além de aumentar a probabilidade de os consumidores doarem, enquanto o apelo de orgulho hubrístico estimulou maior efeito de orgulho autêntico. Desta forma, foi evidenciado que o orgulho é uma emoção unidimensional no contexto nacional do consumidor de cosméticos orgânicos. Em seguida, descobriu-se que o apelo de orgulho unidimensional despertou uma maior atitude favorável e intenção de compra do produto anunciado em comparação às emoções culpa, medo e alegria. Conclusão: os achados reposicionam a discussão sobre o orgulho sob uma perspectiva unidimensional, pois o orgulho autêntico estimulou alegria. Ademais, os apelos positivos são mais eficazes para aumentar a intenção comportamental de cosméticos orgânicos. Em divergência com pesquisas anteriores, o orgulho provoca maiores atitudes favoráveis em relação ao produto anunciado. Portanto, para a conscientização do consumidor deve-se incentivar o uso de apelo de orgulho. Objetivo pessoais teórico utilizouse utilizou se culpa forma utilizaramse utilizaram Metodologia reais withinsubjects within subjects betweensubjects, betweensubjects between , between-subjects) realizados ANOVA Resultados alegria doarem seguida descobriuse descobriu Conclusão Ademais anteriores Portanto devese deve between-subjects

ABSTRACT Objective: To present the theoretical-methodological potential of Critical Discourse Analysis (CDA) for critical studies of Documentary Languages (DL). It starts from Norman Fairclough's CDA assumptions, as well as from the semantic warrants principle to discuss the thematic/discursive representation of social actors. The concepts of “discourse”, “social practice”, “discursive practice”, “text”, “power”, “hegemony”, “ideology” and “semantic warrants” are used to propose the three-dimensional model of analysis, in which DL would be analyzed in three dimensions: DL as a text, DL as a discursive practice and DL as a social practice. Methods: It uses exploratory and bibliographic research methods, with a qualitative approach. Results: The results indicate that Fairclough's Dialectical-Relational approach provides concepts, tools and categories necessary to work on socio-discursive issues involving the use of language in the representation of documentary content, especially content that involves minorized social groups, such as blacks, indigenous people, women, LGBTQIAP+, among other social groups in vulnerable situations. Conclusions: It is concluded that Fairclough's approach with the use of categories oriented to the senses of words can be operationalized to understand how social actors are being represented in the discourses of DL and how the pattern of inclusion and exclusion of these actors in the process of thematic representation of documents. Objective theoreticalmethodological theoretical methodological (CDA DL. . (DL) Faircloughs Fairclough s assumptions thematicdiscursive discourse, discourse , “discourse” practice, practice” text “text” power, power “power” hegemony, hegemony “hegemony” ideology “ideology threedimensional dimensional analysis dimensions Methods methods Results DialecticalRelational Dialectical Relational sociodiscursive socio blacks people women LGBTQIAP LGBTQIAP+ situations Conclusions documents (DL “discourse “text “power “hegemony

RESUMO Objetivo: Apresentar o potencial teórico-metodológico da Análise de Discurso Crítica (ADC) para os estudos críticos de Linguagens Documentárias (LD). Parte dos pressupostos da ADC de Norman Fairclough, bem como do princípio de garantia semântica para discutir a representação temática/discursiva de atores sociais. Recorre-se aos conceitos de “discurso”, “prática social”, “prática discursiva”, “texto”, “poder”, “hegemonia”, “ideologia” e “garantia semântica” para propor o modelo tridimensional de análise, no qual a LD seria analisada em três dimensões: LD enquanto texto, LD enquanto prática discursiva e LD enquanto prática social. Método: Utiliza os métodos de pesquisa exploratória e bibliográfica, com abordagem qualitativa. Resultado: Os resultados apontam que a abordagem Dialético-Relacional de Fairclough fornece conceitos, ferramentas e categorias necessárias para trabalhar questões sociodiscursivas envolvendo o uso da linguagem na representação de conteúdos documentais, principalmente conteúdos que envolvem grupos sociais minorizados, tais como negros, indígenas, mulheres, LGBTQIAP+, dentre outros grupos sociais em situações de vulnerabilidades. Conclusões: Conclui-se que a abordagem de Fairclough com a utilização de categorias orientadas para os sentidos das palavras podem ser operacionalizadas para entender de que modo atores sociais estão sendo representados nos discursos das LD e de que forma se dá o padrão de inclusão e exclusão desses atores no processo de representação temática dos documentos. Objetivo teóricometodológico teórico metodológico (ADC LD. . (LD) temáticadiscursiva Recorrese Recorre discurso, discurso , “discurso” social, social social” discursiva, discursiva” texto “texto” poder, poder “poder” hegemonia, hegemonia “hegemonia” ideologia “ideologia análise dimensões Método bibliográfica qualitativa Resultado DialéticoRelacional Dialético Relacional documentais minorizados negros indígenas mulheres LGBTQIAP LGBTQIAP+ vulnerabilidades Conclusões Concluise Conclui documentos (LD “discurso “texto “poder “hegemonia

RESUMEN Objetivo: Describir situaciones de violencia contra la mujer en la pandemia de Covid-19 reportadas en los medios de comunicación. Método: Investigación documental, cualitativa, en ambiente virtual, realizada con 39 reportajes publicados en el diario O Globo y el portal Universo On-line, entre marzo de 2020 y julio de 2021, en Salvador - BA. La organización de los datos siguió los pasos del análisis de contenido, con una discusión basada en la literatura científica. Resultados: En el proceso de análisis se organizaron cuatro núcleos de significados: el aislamiento social denuncia situaciones de violencia intrafamiliar; Crisis económica y puertas cerradas: ¿justifican más violencia?; Herramientas disponibles para acabar con la violencia contra las mujeres: ¿qué cambia con la pandemia?; El género y el color de la violencia en la pandemia. Consideraciones finales: Los medios de comunicación dieron a conocer datos alarmantes sobre el recrudecimiento y la susceptibilidad de las mujeres a diferentes tipos y situaciones de violencia, especialmente durante el aislamiento social, en la pandemia del Covid-19. Objetivo Covid19 Covid 19 Covid-1 Método documental cualitativa virtual 3 Online, Online On line, line On-line 202 2021 BA contenido científica Resultados significados intrafamiliar cerradas justifican violencia? qué pandemia? finales Covid19. 19. Covid1 1 Covid- 20 2

ABSTRACT Objective: To describe situations of violence against women in the Covid-19 pandemic reported in the media. Method: Documentary, qualitative research, in a virtual environment, carried out with 39 reports published in the newspaper O Globo and the Universo On-line portal, between March 2020 and July 2021, in Salvador - BA. Data organization followed the steps of content analysis, with a discussion based on the scientific literature. Results: In the analysis process, four core meanings were organized: social isolation denounces situations of domestic violence; Economic crisis and closed doors: justify more violence?; Tools available for ending violence against women: what changes with the pandemic?; The gender and color of violence in the pandemic. Final considerations: The media released alarming data on the intensification and susceptibility of women to different types and situations of violence, especially during social isolation, in the Covid-19 pandemic. Objective Covid19 Covid 19 Covid-1 Method Documentary research environment 3 Online On line portal 202 2021 BA literature Results process organized doors violence? pandemic? considerations Covid1 1 Covid- 20 2

RESUMO Objetivo: Descrever as situações de violência contra mulheres na pandemia de Covid-19 divulgadas na mídia. Método: Pesquisa documental, qualitativa, em ambiente virtual, realizada com 39 reportagens divulgadas no jornal O Globo e portal Universo On-line ,entre março de 2020 a julho de 2021, em Salvador - BA. A organização dos dados seguiu as etapas da análise de conteúdo, com discussão fundamentada na literatura científica. Resultados: No processo de análise foram organizados quatro núcleos de sentido: o isolamento social denuncia situações de violência doméstica; Crise econômica e portas fechadas: justifica mais violências?; Ferramentas disponíveis para o rompimento da violência contra mulher: o que muda com a pandemia?; O gênero e a cor da violência na pandemia. Considerações finais: A mídia divulgou dados alarmantes sobre a intensificação e susceptibilidade das mulheres aos diversos tipos e situações de violência, principalmente durante o isolamento social, na pandemia de Covid-19. Objetivo Covid19 Covid 19 Covid-1 Método documental qualitativa virtual 3 Online On line entre 202 2021 BA conteúdo científica Resultados sentido doméstica fechadas violências violências? mulher pandemia? finais Covid19. 19. Covid1 1 Covid- 20 2

Abstract Introduction Ideal timing of Renal Replacement Therapy (RRT) discontinuation in Acute Kidney Injury (AKI) is still unknown. We aimed to study the role of creatinine-related variables in predicting RRT successful discontinuation and to propose a clinical predictive score. Methods In this single-centre retrospective study, we evaluated all AKI patients in whom RRT was interrupted for at least 48 hours. Patients who were still RRT-independent 7 days after initial RRT cessation were included in the “Success” group and opposed to the “Failure” group. We evaluated baseline characteristics and variables collected at the time of RRT interruption, as well as the Kinetic estimated Glomerular Filtration Rate (KeGFR), the simple variation in serum Creatinine (ΔsCr), and the incremental creatinine ratio on the first three days after RRT interruption. Multivariable analysis was performed to evaluate prediction of success. Internal validation using a simple binomial generalized regression model with Lasso estimation and 5-fold cross validation method was performed. Results We included 124 patients, 49 in the “Failure” group and 75 in the “Success” group. All creatinine-related variables predicted success in simple and multiple logistic regression models. The best model generated a clinical score based on the odds ratio obtained for each variable and included urine output, non-renal SOFA score, fluid balance, serum urea, serum potassium, blood pH, and the variation in sCr values after RRT discontinuation. The score presented an area under the ROC of 0.86 (95% CI 0.76‒1.00). Conclusion Creatinine variation between the first 2 consecutive days after RRT discontinuation might predict success in RRT discontinuation. The developed clinical score based on these variables might be a useful clinical decision tool to guide hemodialysis catheter safe removal. (RRT (AKI unknown creatininerelated related singlecentre single centre 4 hours RRTindependent independent Success “Success Failure “Failure interruption KeGFR, KeGFR , (KeGFR) ΔsCr, ΔsCr (ΔsCr) 5fold fold 5 12 models output nonrenal non renal balance urea potassium pH 086 0 86 0.8 95% 95 (95 0.76‒1.00. 076100 0.76‒1.00 . 76 1 00 0.76‒1.00) removal (KeGFR (ΔsCr 08 8 0. 9 (9 07610 0.76‒1.0 ( 0761 0.76‒1. 076 0.76‒1 07 0.76‒ 0.76 0.7

BACKGROUND A positive Trypanosoma cruzi polymerase chain reaction (PCR) is associated with a worse prognosis in patients with chronic Chagas disease (CD). OBJECTIVES To study the association of clinical, electrocardiographic, and echocardiographic characteristics and biomarker blood levels with positive T. cruzi PCR in chronic CD. METHODS This is a single-centre observational cross-sectional study. Positive T. cruzi PCR association with clinical, electrocardiographic, and echocardiographic characteristics, and biomarker blood levels were studied by logistic regression analysis. p values < 0.05 were considered significant. FINDINGS Among 333 patients with chronic CD (56.4% men; 62 ± 10 years), T. cruzi PCR was positive in 41.1%. Stepwise multivariate logistic regression showed an independent association between positive T. cruzi PCR and diabetes mellitus {odds ratio (OR) 0.53 [95% confidence interval (CI) 0.30-0.93]; p = 0.03}, right bundle branch block [OR 1.78 (95% CI 1.09-2.89); p = 0.02], and history of trypanocidal treatment [OR 0.13 (95% CI 0.04-0.38); p = 0.0002]. Among patients with a history of trypanocidal treatment (n = 39), only four (10%) patients had a positive T. cruzi PCR. MAIN CONCLUSIONS Among several studied parameters, only diabetes mellitus, right bundle branch block, and history of trypanocidal treatment showed an independent association with positive T. cruzi PCR. History of trypanocidal treatment was a strong protective factor against a positive T. cruzi PCR. (PCR . (CD) clinical electrocardiographic T singlecentre single centre crosssectional cross sectional analysis 005 0 05 0.0 significant 33 56.4% 564 56 4 (56.4 men 6 1 years, years , years) 411 41 41.1% odds OR (OR 053 53 0.5 95% 95 [95 (CI 0.300.93 030093 0.30 0.93 30 93 0.30-0.93] 0.03, 003 0.03 03 0.03} 178 78 1.7 (95 1.092.89 109289 1.09 2.89 09 2 89 1.09-2.89) 0.02, 002 0.02 02 0.02] 013 13 0.1 0.040.38 004038 0.04 0.38 04 38 0.04-0.38) 0.0002. 00002 0.0002 0002 0.0002] n 39, 39 39) 10% (10% parameters (CD 00 0. 3 56.4 5 (56. 41.1 9 [9 300 0.300.9 03009 030 0.3 093 0.9 0.30-0.93 17 7 1. (9 092 1.092.8 10928 109 1.0 289 2.8 8 1.09-2.89 01 040 0.040.3 00403 004 038 0.04-0.38 0000 0.000 000 (10 56. (56 41. [ 0.300. 0300 0.30-0.9 ( 1.092. 1092 28 2. 1.09-2.8 0.040. 0040 0.04-0.3 0.00 (1 (5 0.300 0.30-0. 1.092 1.09-2. 0.040 0.04-0. 0.30-0 1.09-2 0.04-0 0.30- 1.09- 0.04-

ABSTRACT. The selection of superior sweet potato genotypes using Bayesian inference is an important strategy for genetic improvement. Sweet potatoes are of social and economic importance, being the material for ethanol production. The estimation of variance components and genetic parameters using Bayesian inference is more accurate than that using the frequently used statistical methodologies. This is because the former allows for using a priori knowledge from previous research. Therefore, the present study estimated genetic parameters and selection gains, predicted genetic values, and selected sweet potato genotypes using a Bayesian approach with a priori information. Root shape, soil insect resistance, and root and shoot productivity of 24 sweet potato genotypes were measured. Heritability, genotypic variation coefficient, residual variation coefficient, relative variation index, and selection gains direct, indirect and simultaneous were estimated, and the data were analyzed using Bayesian inference. Data from 11 experiments were used to obtain a priori information. Bayesian inference was a useful tool for decision-making, and significant genetic gains could be achieved with the selection of the evaluated genotypes. Root shape, soil insect resistance, commercial root productivity, and total root productivity showed higher heritability values. Clones UFVJM06, UFVJM40, UFVJM54, UFVJM09, and CAMBRAIA can be used as parents in future breeding programs.

ABSTRACT The improvement of sweet potato is a costly job due to the large number of characteristics to be analyzed for the selection of the best genotypes, making it necessary to adopt new technologies, such as the use of images, associated with the phenotyping process. The objective of this research was to develop a methodology for the phenotyping of the root production aiming genetic improvement of half-sib sweet potato progenies through computational analysis of images and to compare its performance to the traditional methodology of evaluation. Sixteen half-sib sweet potato families in a randomized block design with 4 replications were evaluated. At plant level, the weight per root and the total number of roots were evaluated. The images were acquired in a “studio” made of mdf with a digital camera model Canon PowerShotSX400 IS, under artificial lighting. The evaluations were carried out using the R software, where a second-degree polynomial regression model was fitted to predict the root weight (in grams) and the genetic values and expected gains were obtained. It was possible to predict the root weight at plant and plot level, obtaining high coefficients of determination between the predicted and observed weight. Computer vision allowed the prediction of root weight, maintaining the genotype ranking and consequently the similarity between the expected gains with the selection. Thus, the use of images is an efficient tool for sweet potato genetic improvement programs, assisting in the crop phenotyping process. genotypes technologies process halfsib half sib evaluation evaluated level studio “studio PowerShotSX PowerShotSX40 IS lighting software seconddegree second degree grams obtained Thus programs PowerShotSX4

RESUMO O melhoramento da batata-doce é um trabalho oneroso em decorrência do grande número de características analisadas para a seleção dos melhores genótipos, fazendo-se necessária a adoção de novas tecnologias, como o uso de imagens, associadas ao processo de fenotipagem. Objetivou-se desenvolver uma metodologia para a fenotipagem da produção de raízes para o melhoramento genético de progênies de meios irmãos de batata-doce por meio da análise computacional de imagens e comparar seu desempenho com a metodologia tradicional de avaliação. Foram avaliadas 16 famílias de meios irmãos de batata-doce em delineamento de blocos casualizados com 4 repetições. Avaliou-se a nível de plantas o peso por raiz. As imagens foram adquiridas em um “estúdio” feito com mdf com uma câmera digital modelo Canon PowerShotSX400 IS, sob iluminação artificial. As avaliações foram realizadas no software R, onde para a predição do peso das raízes (em gramas) foi ajustado um modelo de regressão polinomial de segundo grau e foram obtidos os valores genéticos e ganhos esperados. Foi possível predizer o peso das raízes a nível de plantas e de parcelas, obtendo altos coeficientes de determinação entre o peso predito e observado. A visão computacional permitiu a predição do peso das raízes, mantendo o ranqueamento dos genótipos e consequentemente a similaridade entre os ganhos esperados com a seleção. Assim, o uso de imagens é uma ferramenta eficiente para programas de melhoramento genético da batata-doce, auxiliando no processo de fenotipagem da cultura. batatadoce batata doce fazendose fazendo se tecnologias Objetivouse Objetivou avaliação 1 repetições Avaliouse Avaliou raiz estúdio “estúdio PowerShotSX PowerShotSX40 IS artificial R gramas parcelas observado Assim batatadoce, doce, cultura PowerShotSX4