Pesquisa | SciELO

ABSTRACT The objective of this study was to examine the effect of the increasing levels of inclusion of palm kernel cake (PKC) in the diet on the performance of feedlot heifers. Forty-eight Nelore heifers with an initial weight of 274 ± 4.58 kg, at 24 months of age, were confined for 98 days in a feedlot. The animals were allocated to the four treatments in a completely randomized design. Treatments consisted of PKC levels of 0 (control), 10, 20, and 30% in the total dry matter of the diet. The roughage:concentrate ratio in the diets was 30:70. Ether extract intake increased, whereas the intakes of non-fiber carbohydrates and total digestible nutrients decreased with the inclusion of PKC. The apparent digestibility of all nutrients decreased, as well as the amounts of nitrogen digested and retained. Microbial protein synthesis and its efficiency also declined. The inclusion of up to 20% PKC increased feeding time and reduced rumination time of heifers. Intake and rumination efficiencies decreased with the inclusion of PKC in the diet. Final weight and average daily gain did not change, but feed efficiency increased with the inclusion of PKC. The inclusion of up to 30% PKC in the diet of feedlot heifers is recommended. (PKC Fortyeight Forty eight 27 458 4 58 4.5 kg 2 age 9 design control, control , (control) 10 20 30 roughageconcentrate roughage concentrate 3070. 3070 70. 70 30:70 nonfiber non fiber retained declined change recommended 45 5 4. (control 1 3 307 7 30:7 30:

https://doi.org/10.37496/rbz5320230132

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila Rêgo, Jozelia Machado, Ketty Lysie Libardi Lira Miyamoto, Samira Tatiyama Burian, Ana Paula Neves Dias, Laiza Hombre Pretti, Flavia Zon Batista, Danielle Cristina Filgueira Alves Mill, José Geraldo Oliveira, Yasmin Gurtler Pinheiro de Gadelha, Carolina Strauss Estevez Gouveia, Maria da Penha Gomes Moulin, Anna Carolina Simões Souza, Bárbara Oliveira Aguiar, Laura Gonçalves Rodrigues Vieira, Gabriel Smith Sobral Grillo, Luiza Lorenzoni Lima, Marina Deorce de Pasti, Laís Pizzol Surlo, Heitor Filipe Faé, Filipe Moulaz, Isac Ribeiro Macabú, Mariana de Oliveira Ribeiro, Priscila Dias Cardoso Magalhães, Vanessa de Oliveira Aguiar, Mariana Freitas de Biegelmeyer, Erika Peixoto;, Flávia Maria Matos Melo Campos Kayser, Cristiane Souza, Alexandre Wagner Silva de Castro, Charlles Heldan de Moura Ribeiro, Sandra Lúcia Euzébio Telles, Camila Maria Paiva França Bühring, Juliana Lima, Raquel Lima de Santos, Sérgio Henrique Oliveira Dos Dias, Samuel Elias Basualto Melo, Natália Seixas de Sanches, Rosely Holanda da Silva Boechat, Antonio Luiz Sartori, Natália Sarzi Hax, Vanessa Dória, Lucas Denardi Rezende, Rodrigo Poubel Vieira de Baptista, Katia Lino Fortes, Natália Rodrigues Querido Melo, Ana Karla Guedes de Melo, Tâmara Santos Vieira, Rejane Maria Rodrigues de Abreu Vieira, Adah Sophia Rodrigues Kakehasi, Adriana Maria Tavares, Anna Carolina Faria Moreira Gomes Landa, Aline Teixeira de Costa, Pollyana Vitoria Thomaz da Azevedo, Valderilio Feijó Martins-Filho, Olindo Assis Peruhype-Magalhães, Vanessa Pinheiro, Marcelo de Medeiros Monticielo, Odirlei André Reis-neto, Edgard Torres Dos Ferreira, Gilda Aparecida Souza, Viviane Angelina de Teixeira-Carvalho, Andréa Xavier, Ricardo Machado Sato, Emilia Inoue Valim, Valeria Pileggi, Gecilmara Salviato Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Resumo: En | Texto: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

Cocoa flavanol supplementation in optimizing post-exercise glycemic control in rats with normoglycemia or diabetes mellitus: findings from the ECODIA study postexercise post exercise mellitus
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Melo, Bruno Pereira

; Oliveira, Joyce Camilla Cruz de

; Zacarias, Aline Cruz

; Cordeiro, Letícia Maria de Souza

; Rodrigues, João Gabriel da Silveira

; Santos, Mara Lívia dos

; Avelar, Gleide Fernandes de

; Meeusen, Romain

; Heyman, Elsa

; Gomes, Camila Berbert

; Ogando, Pedro Henrique Madureira

; Soares, Danusa Dias

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e240169

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: This study investigated the acute effects of cocoa flavanol (CF) supplementation on glucose homeostasis, aerobic performance, and lactate concentration in rats with type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and normoglycemia (NORM). Materials and methods: The study included 28 male Wistar rats (220-290 g). Induction of T1DM (n = 8) was achieved through intraperitoneal injection of streptozotocin, while T2DM (n = 10) was induced using an ad libitum high-fat diet combined with a fructose-rich beverage. The rats in the NORM group (n = 10) received a standard diet for 30 days. Two experiments were conducted: (1) T1DM rats performed two successive 30-minute treadmill runs below the anaerobic threshold and (2) T2DM and NORM rats underwent two incremental maximal treadmill running tests, both after CF or placebo supplementation. Blood glucose concentrations were measured from pre-exercise to 60 minutes post-exercise. Results: Glycemic reduction at 60 minutes post-exercise was significantly potentiated by CF compared with placebo supplementation in T1DM, T2DM, and normoglycemic rats (p < 0.05 for all). In T2DM rats, CF induced a glycemic response comparable to the NORM placebo-supplemented condition. These effects of CF persisted despite variations in aerobic performance or lactate concentration after incremental exercise. Conclusion: Supplementation with CF prior to physical exercise elicited a pronounced post-aerobic exercise glycemic reduction. This represents a promising strategy for mitigating the duration of hyperglycemia exposure after physical exercise. Objective (CF homeostasis TDM , T DM (T1DM) (T2DM) NORM. . (NORM) methods 220290 220 290 (220-29 g. g g) n 8 streptozotocin 10 highfat high fat fructoserich fructose rich beverage 3 days conducted (1 30minute minute (2 tests preexercise pre 6 postexercise. postexercise post Results p 005 0 05 0.0 all. all all) placebosupplemented supplemented condition Conclusion postaerobic (T1DM (T2DM (NORM 22029 22 29 (220-2 ( 00 0. 2202 (220- (220 (22

https://doi.org/10.20945/2359-4292-2024-0169

Tuberculosis trend among the indigenous peoples of the Brazilian Amazon from 2001 to 2022 200 202 20 2
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CARRASCO, Leny Meire Correa Molinari

; RODRIGUES, Gabriel Lopes

; SANTOS, Hendrega Nadynne de Oliveira

; MARINHO, Giovanna Machado

; PEREIRA, Thayza Miranda

; MONTEIRO, Lorena Dias

Acta Amazonica

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2024, Volume 54 Nº 4 elocation e54hs24120

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A tuberculose (TB) continua sendo uma preocupação significativa de saúde pública entre os povos indígenas na Amazônia brasileira. Este estudo teve como objetivo descrever as características epidemiológicas e as tendências temporais dos indicadores de TB nessa população de 2001 a 2022. Analisamos dados de novos casos de TB autodeclarados por indígenas na área da Amazônia Legal a partir do banco de dados DATASUS do Ministério da Saúde do Brasil. Os indicadores de TB foram calculados e as tendências temporais foram analisadas usando regressão joinpoint. Um total de 9.245 casos de TB foram registrados entre os residentes indígenas. Os homens foram os mais afetados de 2001 a 2022, exceto 2019. Os casos de TB diminuíram significativamente de 2001 a 2022 [mudança percentual média anual (AAPC) = -2,7%; intervalo de confiança (IC) de 95% = -3,6 a -1,7]. Foi observada uma considerável redução na incidência nos estados de Rondônia (APC = -7,4%, IC = -1,0 a -4,8), Acre (APC = -3,2%, IC = -5,4 a -0,9), Amazonas (APC = -4,1%, IC = -4,9 a -3,3%) e Tocantins (APC = -3,3%, IC = -5,8 a -0,7) . No estado de Mato Grosso, ocorreu um aumento significativo de 2012 a 2015 (APC = 46,6%, IC = -28,4 a 200,0). A incidência de TB continua alta entre os povos indígenas na Amazônia Legal em comparação com a população geral da região e do Brasil, apesar das tendências de declínio no período. (TB brasileira 200 Brasil joinpoint 9245 9 245 9.24 2019 202 mudança AAPC (AAPC 2,7% 27 2 7 -2,7% (IC 95 3,6 36 3 6 -3, 1,7. 17 1,7 1 -1,7] APC 7,4%, 74 4 -7,4% 1,0 10 0 -1, 4,8, 48 4,8 , 8 -4,8) 3,2%, 32 -3,2% 5,4 54 5 -5, 0,9, 09 0,9 -0,9) 4,1%, 41 -4,1% 4,9 49 -4, 3,3% 33 -3,3% 3,3%, 5,8 58 0,7 07 -0,7 Grosso 201 466 46 46,6% 28,4 284 28 -28, 200,0. 2000 200,0 200,0) período 20 924 24 9.2 2,7 -2,7 3, -3 1, -1,7 7,4% -7,4 -1 4, -4,8 3,2% -3,2 5, -5 0, -0,9 4,1% -4,1 -4 3,3 -3,3 -0, 46,6 28, -28 200, 92 9. 2, -2, - 7,4 -7, 3,2 4,1 -0 46, -2 7, -7

ABSTRACT Tuberculosis (TB) remains a significant public health concern among indigenous peoples in the Brazilian Amazon. This study aimed to describe the epidemiological characteristics and temporal trends of TB indicators within this population from 2001 to 2022. We analyzed data on new self-reported TB cases by indigenous people in the area of the Legal Amazon from the DATASUS database of the Brazilian Health Ministry. TB indicators were calculated, and temporal trends were analyzed using joinpoint regression. A total of 9,245 TB cases were registered among indigenous residents. Men were the most affected from 2001 to 2022, except in 2019. TB cases significantly decreased from 2001 to 2022 [average annual percent change (AAPC) = -2.7%; 95% confidence interval (CI) = -3.6 to -1.7]. A considerable decline in incidence was observed in the states of Rondônia (APC = -7.4%, CI = -1.0 to -4.8) , Acre (APC = -3.2%, CI = -5.4 to -0.9), Amazonas (APC = -4.1%, CI = -4.9 to -3.3%) and Tocantins (APC = -3.3%, CI = -5.8 to -0.7). In Mato Grosso state, a significant increase occurred from 2012 to 2015 (APC = 46.6%, CI = -28.4 to 200.0). TB incidence remains high among indigenous peoples in the Legal Amazon compared to the general population of the region and Brazil, despite declining trends in the period. (TB 200 selfreported self reported Ministry calculated regression 9245 9 245 9,24 residents 2019 202 average AAPC (AAPC 2.7% 27 2 7 -2.7% 95 (CI 3.6 36 3 6 -3. 1.7. 17 1.7 . 1 -1.7] APC 7.4%, 74 4 -7.4% 1.0 10 0 -1. 4.8 48 8 -4.8 3.2%, 32 -3.2% 5.4 54 5 -5. 0.9, 09 0.9 -0.9) 4.1%, 41 -4.1% 4.9 49 -4. 3.3% 33 -3.3% 3.3%, 5.8 58 0.7. 07 0.7 -0.7) state 201 466 46 46.6% 28.4 284 28 -28. 200.0. 2000 200.0 200.0) Brazil period 20 924 24 9,2 2.7 -2.7 3. -3 1. -1.7 7.4% -7.4 -1 4. 3.2% -3.2 5. -5 0. -0.9 4.1% -4.1 -4 3.3 -3.3 -0.7 46.6 28. -28 200. 92 9, 2. -2. - 7.4 -7. 3.2 -0. 4.1 46. -2 7. -7 -0

https://doi.org/10.1590/1809-4392202401203

Sampling Reflex as a New Manometric Marker in the Diagnosis of Defecation Disorders - Systematic Review
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Schlenstein, Henrique Perobelli

; Silva, Gabriel Thiago da Caliman, Gabriella Catharino Andrade, Izabella Dias Muniz de Rodrigues, Marina Silva Vitoretti, Matheus Gentile, Renato Migliore João Kleber de Almeida

Journal of Coloproctology (Rio de Janeiro)

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Jul 2023, Volume 43 Nº 3 Páginas 159 - 165

Resumo: En | Texto: En | PDF: En

ABSTRACT Introduction: Distension of the rectum wall and subsequent momentary relaxation of the internal anal sphincter (IAS) trigger a reflex called the rectoanal inhibitory reflex (RAIR). This same rectal distension causes a reflex contraction of the external anal sphincter (EAS), responsible for conscious continence called rectoanal excitatory reflex (RAER). This set of reflexes are named sampling reflex. Objectives: The sampling reflex is necessary to initiate defecation or flatulence. The objective of this study is to evaluate the sampling reflex and its practical applicability as a manometric marker of the main defecation disorders. Methodology: This review followed the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) items. The development method consisted of searching for articles in the research platforms BVS, PubMed, Cochrane Library, SciELO and ScienceDirect and for the selection of articles the Rayyan Platform was used. The articles resulting from the search strategies were added to the platform and five collaborators were invited for the blind selection. Finally, 6 articles were included in the final review. Results: An intact sampling reflex allows the individual to facilitate discrimination between flatus and stool and to choose whether to discharge or retain rectal contents. On the other hand, an impaired sampling reflex can predispose an individual to incontinence. Therefore, it was observed that patients with defecation disorders had an impaired sampling reflex, since it was found that constipated patients have incomplete opening of the IAS, lower amplitude of RAIR and increase of RAER. Most incontinent patients present a failure in the recruitment of the EAS, a decrease in the RAER and an increase in the RAIR, in duration and amplitude.

https://doi.org/10.1055/s-0043-1773800

Genetic dissimilarity for thermoinhibition in seeds of lettuce lines after defoliation
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Catão, Hugo Cesar Rodrigues Moreira

; Maciel, Gabriel Mascarenhas Gomes, Luiz Antonio Augusto Siquieroli, Ana Carolina Silva Luz, José Magno Queiroz Cabral Neto, Luciano Dias

Acta Scientiarum. Agronomy

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2023, Volume 45 elocation e56518

Resumo: En | Texto: En | PDF: En

ABSTRACT. Removal of lettuce basal leaves is a technique used by the seed industry; however, the effects on seed production and physiological potential are unknown. Genetic dissimilarity is fundamental in the identification of individuals in terms of traits of interest, although it is rarely considered in relation to seeds that are tolerant to thermoinhibition. The aim of this study was to ascertain the relationship between defoliation of lettuce plants and seed yield/physiological quality, as well as the genetic dissimilarity among genotypes with regard to seed thermoinhibition. We used 35 lines of biofortified lettuce, the cultivars Uberlândia 10000, Belíssima, UFU MC BIOFORT1, and Everglades (tolerant to thermoinhibition), and Grand Rapids and Verônica (susceptible to thermoinhibition). The seed yield and physiological quality of the genotypes with and without defoliation were evaluated, artificially aged, and germinated at four temperatures in a factorial arrangement. The genetic dissimilarity was estimated by Tocher graphing and the UPGMA clustering method, based on the Mahalanobis generalized distance (D2 ii). Four UFU genotypes and Grand Rapids had high seed yields. With removal of basal leaves, there was higher seed yield per plant and there was an effect on their physiological quality. The genotypes exhibited genetic variability for thermoinhibition, with UFU-86#2#1#1 and Everglades showing similar performance.

https://doi.org/10.4025/actasciagron.v45i1.56518

Calcium carbide in anticipation and standardization of ripening in Cajá-manga fruits Cajámanga Cajá manga
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Gomes, Francielly Rodrigues

; Silva, Danielle Fabíola Pereira da

; Costa, Gabriel Silva

; Souza, Pedro Henrique Magalhães de

; Silveira-Neto, Américo Nunes da

; Cruz, Simério Carlos Silva

Revista Brasileira de Fruticultura

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2023, Volume 45 elocation e-139

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O amadurecimento de frutos promovido pela aplicação exógena de análogos de etileno, como o carbureto de cálcio, tem vantagens comerciais. Assim, o conhecimento das respostas de frutos tratados com agentes indutores de etileno é essencial para otimizar o uso dessas substâncias. Este trabalho teve como objetivo avaliar a influência da exposição ao carbureto de cálcio na antecipação e na padronização do amadurecimento pós-colheita de frutos de cajá-manga. Frutos fisiologicamente maduros foram expostos ao carbureto de cálcio nas concentrações de 0; 20; 40; 80 e 110 g m-3 por 24 horas. Os frutos foram armazenados a uma temperatura de 28±2 °C e avaliados aos 0; 2; 4 e 6 dias quanto à perda de massa fresca, cor da epiderme e polpa dada pelo espaço de cor CIELAB, acidez titulável, teor de sólidos solúveis, relação entre o teor de sólidos solúveis e a acidez titulável, e teor de vitamina C. Frutos de cajá-manga tratados com diferentes concentrações de carbureto de cálcio tiveram seu amadurecimento antecipado sem comprometer suas características. As concentrações de 20; 40 e 80 g m-3 de carbureto de cálcio permitiram a antecipação e a padronização do amadurecimento dos frutos em quatro dias, durante o armazenamento, Enquanto para a maior concentração (110 g m-3), a maturação completa foi acelerada, ocorrendo entre dois e quatro dias de armazenamento. comerciais Assim substâncias póscolheita pós colheita cajámanga. cajámanga cajá manga. manga 0 20 8 11 m3 m 3 m- 2 horas 282 28 28± C fresca CIELAB titulável características armazenamento (11 m3, , m-3) acelerada 1 (1 (

Abstract Fruit ripening promoted by the exogenous application of ethylene analogs, such as calcium carbide, has commercial advantages. Thus, the knowledge of the responses of fruits treated with ethylene-inducing agents is essential to optimize the use of these substances. This work aimed to evaluate the influence of exposure to calcium carbide on the anticipation and standardization of postharvest ripening of cajá-manga fruits. Physiologically mature fruits were exposed to calcium carbide for 24 hours at concentrations 0, 20, 40, 80, and 110 g m-3. The fruits were stored at a temperature of 28±2 °C and evaluated at 0, 2, 4, and 6 days for the loss of fresh mass, color of the epidermis and pulp given by the CIELAB color space, titratable acidity, soluble solids content, the ratio between soluble solids content and titratable acidity, and vitamin C content. Cajá-manga fruits treated with different concentrations of calcium carbide had their ripening anticipated without compromising their characteristics. The concentrations of 20, 40, and 80 g m-3 of calcium carbide allowed the anticipation and standardization of fruit ripening within four days during storage, while for the highest concentration (110 g m-3), complete maturation was accelerated, occurring between two and four days of storage. analogs advantages Thus ethyleneinducing inducing substances cajámanga cajá manga 2 0 20 40 11 m3. m3 m 3. 3 282 28 28± 4 mass space acidity Cajámanga Cajá characteristics 8 m- storage (11 m3, , m-3) accelerated 1 (1 (

https://doi.org/10.1590/0100-29452023139

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023 202 20 2
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Marin-Neto, José Antonio

; Rassi Jr, Anis

; Oliveira, Gláucia Maria Moraes

; Correia, Luís Claudio Lemos

; Ramos Júnior, Alberto Novaes

; Luquetti, Alejandro Ostermayer

; Hasslocher-Moreno, Alejandro Marcel

; Sousa, Andréa Silvestre de

; Paola, Angelo Amato Vincenzo de

; Sousa, Antônio Carlos Sobral

; Ribeiro, Antonio Luiz Pinho

; Correia Filho, Dalmo

; Souza, Dilma do Socorro Moraes de

; Cunha-Neto, Edecio

; Ramires, Felix Jose Alvarez

; Bacal, Fernando

; Nunes, Maria do Carmo Pereira

; Martinelli Filho, Martino

; Scanavacca, Maurício Ibrahim

; Saraiva, Roberto Magalhães

; Oliveira Júnior, Wilson Alves de

; Lorga-Filho, Adalberto Menezes

; Guimarães, Adriana de Jesus Benevides de Almeida

; Braga, Adriana Lopes Latado

; Oliveira, Adriana Sarmento de

; Sarabanda, Alvaro Valentim Lima

; Pinto, Ana Yecê das Neves

; Carmo, Andre Assis Lopes do

; Schmidt, Andre

; Costa, Andréa Rodrigues da

; Ianni, Barbara Maria

; Markman Filho, Brivaldo

; Rochitte, Carlos Eduardo

; Macêdo, Carolina Thé

; Mady, Charles

; Chevillard, Christophe

; Virgens, Cláudio Marcelo Bittencourt das

; Castro, Cleudson Nery de

; Britto, Constança Felicia De Paoli de Carvalho

; Pisani, Cristiano

; Rassi, Daniela do Carmo

; Sobral Filho, Dário Celestino

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Mesquita, Evandro Tinoco

; Mendes, Fernanda de Souza Nogueira Sardinha

; Gondim, Francisca Tatiana Pereira

; Silva, Gilberto Marcelo Sperandio da

; Peixoto, Giselle de Lima

; Lima, Gustavo Glotz de

; Veloso, Henrique Horta

; Moreira, Henrique Turin

; Lopes, Hugo Bellotti

; Pinto, Ibraim Masciarelli Francisco

; Ferreira, João Marcos Bemfica Barbosa

; Nunes, João Paulo Silva

; Barreto-Filho, José Augusto Soares

; Saraiva, José Francisco Kerr

; Lannes-Vieira, Joseli

; Oliveira, Joselina Luzia Menezes

; Armaganijan, Luciana Vidal

; Martins, Luiz Cláudio

; Sangenis, Luiz Henrique Conde

; Barbosa, Marco Paulo Tomaz

; Almeida-Santos, Marcos Antonio

; Simões, Marcos Vinicius

; Yasuda, Maria Aparecida Shikanai

; Moreira, Maria da Consolação Vieira

; Higuchi, Maria de Lourdes

; Monteiro, Maria Rita de Cassia Costa

; Mediano, Mauro Felippe Felix

; Lima, Mayara Maia

; Oliveira, Maykon Tavares de

; Romano, Minna Moreira Dias

; Araujo, Nadjar Nitz Silva Lociks de

; Medeiros, Paulo de Tarso Jorge

; Alves, Renato Vieira

; Teixeira, Ricardo Alkmim

; Pedrosa, Roberto Coury

; Aras Junior, Roque

; Torres, Rosalia Morais

; Povoa, Rui Manoel dos Santos

; Rassi, Sergio Gabriel

; Alves, Silvia Marinho Martins

; Tavares, Suelene Brito do Nascimento

; Palmeira, Swamy Lima

; Silva Júnior, Telêmaco Luiz da

; Rodrigues, Thiago da Rocha

; Madrini Junior, Vagner

; Brant, Veruska Maia da Costa

; Dutra, Walderez Ornelas

; Dias, João Carlos Pinto

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 Nº 6 elocation e20230269

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230269

Efficacy, safety, and potential industry bias in using deoxycholic acid for submental fat reduction - A systematic review and meta-analysis of randomized clinical trials
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Inocencio, Gabriel Santiago Giuglio

; Meneses-Santos, Daniela

; Costa, Marcelo Dias Moreira de Assis

; Vieira, Walbert A.

; Almeida, Vinicius Lima de

; Rodrigues, Renata Prata Cunha Bernardes

; Rode, Sigmar de Mello

; Paranhos, Luiz Renato

Clinics

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2023, Volume 78 elocation 100220

Resumo: En | Texto: En | PDF: En

Abstract Lipolytic substance injections to reduce localized fat have been extensively used because it is a low-invasive method. This review aimed to evaluate the efficacy and safety of deoxycholic acid in submental fat reduction compared to a placebo and investigate the potential industry sponsorship bias in the results of randomized clinical trials on this topic. Ten electronic databases were extensively searched for randomized clinical trials without restriction on language and year of publication. Two reviewers extracted the data and assessed the individual risk of bias in the studies with the RoB 2.0 tool. The industry sponsorship bias was evaluated according to citations in the articles regarding industry funding/sponsorship throughout the texts. Fixed and random effects meta-analyses were performed, and the results were reported in Risk Ratio (RR) at a 95% Confidence Interval (95% CI). The initial search provided 5756 results, of which only five were included. Only two studies had a low risk of bias. All studies showed a potential industry bias. The meta-analysis showed that patients treated with deoxycholic acid had significant positive results for all efficacy outcomes and a higher risk of fibrosis, pain, erythema, numbness, swelling, edema, pruritus, nodules, headache, and paresthesia. The low to moderate certainty of evidence found allows concluding that deoxycholic acid is effective in submental fat reduction, causing well-tolerated adverse effects. However, all eligible studies showed a potential industry bias.

https://doi.org/10.1016/j.clinsp.2023.100220

10.

Near infrared spectroscopy and seedling image analysis to evaluate the physiological potential of Urochloa decumbens (Stapf) R.D. Webster seeds
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Souza, Lucas Rodrigues de

; Limão, Marcelo Augusto Rocha

; Pinheiro, Daniel Teixeira

; Peris, Gabriel Cordeiro de Oliveira

; Dias, Denise Cunha Fernandes dos Santos

; Dias, Luiz Antônio dos Santos

Journal of Seed Science

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2023, Volume 45 elocation e202345032

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract: The demand for techniques that make it possible to assess the physiological potential of seeds quickly and assertively make near-infrared spectroscopy (FT-NIR) and seedling analysis using ILASTIK software promising tools. The aim of this study was to evaluate the physiological potential of Urochloa decumbens seeds using near-infrared spectroscopy (FT-NIR) and ILASTIK software. Seeds from 10 lots of U. decumbens were classified according to their physiological potential (germination and vigor) and then FT-NIR spectra were obtained from individual seed samples, the original spectra being pre-processed with different dispersion correction methods used for the construction of a classification model through partial least squares discriminant analysis (PSL-DA). For the ILASTIK evaluation, the seedlings were photographed at 7 and 14 days of germination and the trained classifier was applied to the images, generating data on the numbers of strong seedlings, weak seedlings and non-germinated seeds. With data from the FT-NIR technique pre-processed by the 2nd derivative of Savitzky-Golay, it was possible to obtain a classification model with high efficiency to discriminate the classes regarding the physiological potential of the seeds. ILASTIK was efficient to classify seeds according to their physiological potential after only 7 days of germination. FT-NIR and ILASTIK analyses are non-destructive and fast alternatives, with great potential for quality control of U. decumbens seed lots.

Resumo: A demanda por técnicas que permitam avaliar o potencial fisiológico das sementes de forma rápida e assertiva fazem da espectroscopia no infravermelho próximo (FT-NIR) e da análise de plântulas pelo software ILASTIK ferramentas promissoras. O objetivo do trabalho foi avaliar o potencial fisiológico de sementes de Urochloa decumbens por meio da espectroscopia no infravermelho próximo (FT-NIR) e do software ILASTIK. Sementes de 10 lotes de U. decumbens foram classificadas quanto o potencial fisiológico (germinação e vigor) e depois foram obtidos espectros FT-NIR de amostras individuais de sementes, sendo os espectros originais pré-processados utilizando diferentes métodos de correção de dispersão utilizados para a construção de um modelo de classificação por meio da PLS-DA. Para a avaliação do ILASTIK, as plântulas foram fotografadas aos 7 e 14 dias de germinação e o classificador treinado foi aplicado às imagens, gerando dados de número de plântulas fortes, plântulas fracas e sementes não germinadas. Com os dados da técnica FT-NIR pré-processados pela 2ª derivada de Savitzky-Golay, foi possível obter um modelo de classificação com alta eficiência para discriminar as classes quanto ao potencial fisiológico das sementes. O ILASTIK foi eficiente para a classificação das sementes quanto ao potencial fisiológico com apenas 7 dias de germinação. As análises pelo FT-NIR e ILASTIK são alternativas não destrutivas e rápidas, com grande potencial para o controle de qualidade de lotes de sementes de U. decumbens.

https://doi.org/10.1590/2317-1545v45277021

11.

[SciELO Preprints] - Guideline of the Brazilian Society of Cardiology on Diagnosis and Treatment of Patients with Chagas Disease Cardiomyopathy
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Marin-Neto, José Antonio Rassi Jr., Anis Moraes Oliveira, Gláucia M. Lemos Correia, Luís Claudio Novaes Ramos Jr., Alberto Hasslocher-Moreno, Alejandro Marcel Luquetti Ostermayer, Alejandro Sousa, Andréa Silvestre de Amato Vincenzo de Paola, Angelo Sobral de Sousa, Antonio Carlos Pinho Ribeiro, Antonio Luiz Correia Filho, Dalmo Moraes de Souza, Dilma do Socorro Cunha-Neto, Edecio J. A. Ramires, Felix Bacal, Fernando Pereira Nunes, Maria do Carmo Martinelli Filho, Martino Ibrahim Scanavacca, Maurício Magalhães Saraiva, Roberto Alves de Oliveira Júnior, Wilson M. Lorga-Filho, Adalberto de Jesus Benevides de Almeida Guimarães, Adriana Lopes Latado Braga, Adriana Sarmento de Oliveira, Adriana V. L. Sarabanda, Alvaro Yecê das Neves Pinto, Ana Assis Lopes do Carmo, André Schmidt, André Costa, Andréa Rodrigues da Ianni, Barbara Maria Markman Filho, Brivaldo Eduardo Rochitte, Carlos Thé Macedo, Carolina Mady, Charles Chevillard, Christophe Bittencourt das Virgens, Cláudio Marcelo Nery de Castro, Cleudson De Paoli de Carvalho Britto, Constança Felícia Pisani, Cristiano do Carmo Rassi, Daniela C. Sobral Filho, Dario Rodrigues Almeida, Dirceu A. Bocchi, Edimar T. Mesquita, Evandro de Souza Nogueira Sardinha Mendes, Fernanda Pereira, Francisca Tatiana Sperandio da Silva, Gilberto Marcelo de Lima Peixoto, Giselle Glotz de Lima, Gustavo H. Veloso, Henrique Turin Moreira, Henrique Bellotti Lopes, Hugo Masciarelli Francisco Pinto, Ibraim Pinto Dias, João Carlos Bemfica, João Marcos Silva-Nunes, João Paulo Soares Barreto-Filho, José Augusto Kerr Saraiva, José Francisco Lannes-Vieira, Joseli Menezes Oliveira, Joselina Luzia V. Armaganijan, Luciana Martins, Luiz Cláudio C. Sangenis, Luiz Henrique Barbosa, Marco Paulo Almeida-Santos, Marcos Antônio Simões, Marcos Vinicius Shikanai-Yasuda, Maria Aparecida Vieira Moreira, Maria da Consolação Higuchi, Maria de Lourdes Costa Monteiro, Maria Rita de Cássia Felix Mediano, Mauro Felippe Maia Lima, Mayara T. Oliveira, Maykon Moreira Dias Romano , Minna Nitz, Nadjar de Tarso Jorge Medeiros, Paulo Vieira Alves, Renato Alkmim Teixeira, Ricardo Coury Pedrosa, Roberto Aras, Roque Morais Torres, Rosália dos Santos Povoa, Rui Manoel Rassi, Sérgio Gabriel Salles Xavier, Sérgio Marinho Martins Alves , Silvia B. N. Tavares, Suelene Lima Palmeira, Swamy da Silva Junior, Telêmaco Luiz da Rocha Rodrigues, Thiago Madrini Junior, Vagner Maia da Costa , Veruska Dutra, Walderez

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Data de publicação: 2022-10-11

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This guideline aimed to update the concepts and formulate the standards of conduct and scientific evidence that support them, regarding the diagnosis and treatment of the Cardiomyopathy of Chagas disease, with special emphasis on the rationality base that supported it.nbsp; Chagas disease in the 21st century maintains an epidemiological pattern of endemicity in 21 Latin American countries. Researchers and managers from endemic and non-endemic countries point to the need to adopt comprehensive public health policies to effectively control the interhuman transmission of T. cruzi infection, and to obtain an optimized level of care for already infected individuals, focusing on diagnostic and therapeutic opportunistic opportunities. nbsp; Pathogenic and pathophysiological mechanisms of the Cardiomyopathy of Chagas disease were revisited after in-depth updating and the notion that necrosis and fibrosis are stimulated by tissue parasitic persistence and adverse immune reaction, as fundamental mechanisms, assisted by autonomic and microvascular disorders, was well established. Some of them have recently formed potential targets of therapies.nbsp; The natural history of the acute and chronic phases was reviewed, with enhancement for oral transmission, indeterminate form and chronic syndromes. Recent meta-analyses of observational studies have estimated the risk of evolution from acute and indeterminate forms and mortality after chronic cardiomyopathy. Therapeutic approaches applicable to individuals with Indeterminate form of Chagas disease were specifically addressed. All methods to detect structural and/or functional alterations with various cardiac imaging techniques were also reviewed, with recommendations for use in various clinical scenarios. Mortality risk stratification based on the Rassi score, with recent studies of its application, was complemented by methods that detect myocardial fibrosis.nbsp; The current methodology for etiological diagnosis and the consequent implications of trypanonomic treatment deserved a comprehensive and in-depth approach. Also the treatment of patients at risk or with heart failure, arrhythmias and thromboembolic events, based on pharmacological and complementary resources, received special attention. Additional chapters supported the conducts applicable to several special contexts, including t. cruzi/HIV co-infection, risk during surgeries, in pregnant women, in the reactivation of infection after heart transplantation, and others.nbsp; nbsp;nbsp; Finally, two chapters of great social significance, addressing the structuring of specialized services to care for individuals with the Cardiomyopathy of Chagas disease, and reviewing the concepts of severe heart disease and its medical-labor implications completed this guideline.

Esta diretriz teve como objetivo principal atualizar os conceitos e formular as normas de conduta e evidências científicas que as suportam, quanto ao diagnóstico e tratamento da CDC, com especial ênfase na base de racionalidade que a embasou. A DC no século XXI mantém padrão epidemiológico de endemicidade em 21 países da América Latina. Investigadores e gestores de países endêmicos e não endêmicos indigitam a necessidade de se adotarem políticas abrangentes, de saúde pública, para controle eficaz da transmissão inter-humanos da infecção pelo T. cruzi, e obter-se nível otimizado de atendimento aos indivíduos já infectados, com foco em oportunização diagnóstica e terapêutica. Mecanismos patogênicos e fisiopatológicos da CDC foram revisitados após atualização aprofundada e ficou bem consolidada a noção de que necrose e fibrose sejam estimuladas pela persistência parasitária tissular e reação imune adversa, como mecanismos fundamentais, coadjuvados por distúrbios autonômicos e microvasculares. Alguns deles recentemente constituíram alvos potenciais de terapêuticas. A história natural das fases aguda e crônica foi revista, com realce para a transmissão oral, a forma indeterminada e as síndromes crônicas. Metanálises recentes de estudos observacionais estimaram o risco de evolução a partir das formas aguda e indeterminada e de mortalidade após instalação da cardiomiopatia crônica. Condutas terapêuticas aplicáveis aos indivíduos com a FIDC foram abordadas especificamente. Todos os métodos para detectar alterações estruturais e/ou funcionais com variadas técnicas de imageamento cardíaco também foram revisados, com recomendações de uso nos vários cenários clínicos. Estratificação de risco de mortalidade fundamentada no escore de Rassi, com estudos recentes de sua aplicação, foi complementada por métodos que detectam fibrose miocárdica. A metodologia atual para diagnóstico etiológico e as consequentes implicações do tratamento tripanossomicida mereceram enfoque abrangente e aprofundado. Também o tratamento de pacientes em risco ou com insuficiência cardíaca, arritmias e eventos tromboembólicos, baseado em recursos farmacológicos e complementares, recebeu especial atenção. Capítulos suplementares subsidiaram as condutas aplicáveis a diversos contextos especiais, entre eles o da co-infecção por T. cruzi/HIV, risco durante cirurgias, em grávidas, na reativação da infecção após transplante cardíacos, e outros.nbsp;nbsp;nbsp; Por fim, dois capítulos de grande significado social, abordando a estruturação de serviços especializados para atendimento aos indivíduos com a CDC, e revisando os conceitos de cardiopatia grave e suas implicações médico-trabalhistas completaram esta diretriz.nbsp;

https://doi.org/10.1590/SciELOPreprints.4820

12.

Clinical-epidemiological changes in patients with non-traumatic acute abdomen during the COVID-19 pandemic: a retrospective study
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CASTRO, GUSTAVO RODRIGUES ALVES

; ZWIERZIKOWSKI, TIAGO AUGUSTO

; LEMES, JOÃO GABRIEL DA SILVA

; YUKI, VALERIA MIDORI GUTOSKI

; GOUVEIA, KAUANA OLIVEIRA

; ROGINSKI-GUETTER, CAMILA

Revista do Colégio Brasileiro de Cirurgiões

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2022, Volume 49 elocation e20223303

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RESUMO Objetivo: pretendemos demonstrar as alterações clínicas e a evolução pós-operatória em pacientes com abdome agudo não traumático em tratamento conservador ou cirúrgico durante a pandemia em comparação a período semelhante no ano anterior. Método: estudo retrospectivo unicêntrico, incluindo pacientes que receberam tratamento clínico-cirúrgico no Hospital do Trabalhador com diagnóstico de abdome agudo entre março e agosto de 2020 e período semelhante em 2019. As variáveis estudadas variaram de dados demográficos a índices de isolamento social. Resultados: foram incluídos 515 pacientes, 291 receberam tratamento no período pré-pandemia e 224 na pandemia. Não houve diferença estatística em relação às comorbidades (p=0,0685), tempo para diagnóstico e procura de ajuda médica. Não foram observadas diferenças estatísticas quanto aos dias de internação (p=0,4738) e necessidade de UTI (p=0,2320). Em relação aos óbitos intra-hospitalares, observou-se relevância estatística na idade acima de 60 anos (p=0,002) e ocorreram mais óbitos no período da pandemia (p=0,032). Porém, quando analisamos os fatores associados ao número de dias até o diagnóstico por um médico, não houve diferença estatística. Conclusão: os dados analisados mostraram que o período de pandemia e a idade acima de 60 anos foram as variáveis que aumentaram a razão de chances para o desfecho óbito hospitalar. No entanto, o tempo de internação, dias na unidade de terapia intensiva e complicações cirúrgicas pós-operatórias, não apresentaram diferença significativa.

ABSTRACT Objective: we intend to demonstrate the clinical alterations and the postoperative evolution in patients with acute abdomen non-traumatic in conservative or surgical treatment during the pandemic compared to a similar period in the last year. Method: a single-center retrospective study, including patients who received clinical-surgical treatment at Hospital do Trabalhador diagnosed with acute abdomen between March and August 2020 and a similar period in 2019.Variables studied ranged from demographic data to indices of social isolation. Results: 515 patients were included, 291 received treatment in a pre-pandemic period and 224 during. There was not statistical difference in relation to comorbidities (p=0.0685), time to diagnosis and seeking medical help. No statistical differences were observed in terms of days of hospitalization (p = 0.4738) and ICU need (p=0.2320). Regarding in-hospital deaths, there was statistical relevance in the age above 60 years (p=0.002) and there were more deaths during the pandemic period (p=0.032). However, when we analyze the factors associated with the number of days until diagnosis by a physician, there was no statistical difference. Conclusion: the analyzed data showed that the pandemic period and age over 60 years were the variables that increased the odds ratio for the in-hospital death outcome. However, the length of stay, days in intensive care unit and postoperative surgical complications showed no significant difference.

https://doi.org/10.1590/0100-6991e-20223303-en

13.

Adaptação transcultural do questionário Patient-Reported Outcomes in Obesity (PROS) para utilização no Brasil
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Traebert, Jefferson

; Rodrigues, Michael Douglas

; Chaves, Manuella Souto

; Moritz, Nicole Morem Pilau

; Nunes, Rodrigo Dias

; Cremona-Parma, Gabriel Oscar

; Traebert, Eliane

Revista Brasileira de Epidemiologia

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2022, Volume 25 elocation e220015

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Realizar a adaptação transcultural e a validação, no contexto cultural brasileiro, do instrumento de impacto da obesidade Patient-Reported Outcomes in Obesity (PROS). Métodos: O processo de adaptação transcultural contou com a tradução do idioma original, inglês, para o português, executada por dois tradutores qualificados e independentes. A retrotradução foi realizada por dois professores de inglês, nativos, sem qualquer conhecimento médico nem da escala original. Um comitê de especialistas foi composto de pesquisadores para avaliar as equivalências semântica, idiomática, experiencial e conceitual. O pré-teste da versão brasileira, denominada PROS-Br, foi realizado com dez indivíduos adultos com obesidade. Para a avaliação das propriedades psicométricas, foi realizado um estudo epidemiológico de delineamento transversal. A população foi composta de 120 indivíduos adultos com obesidade, brasileiros, presentes para consulta médica em ambulatório-escola. Para análises psicométricas, foram utilizadas a Teoria de Resposta ao Item e análise fatorial com extração de componentes principais. Para aferição da confiabilidade foi utilizado o indicador α-Cronbach. Resultados: Na análise de confiabilidade, o PROS-Br apresentou α-Cronbach de 0,82. Dois fatores explicaram 58,3% da variância total na análise de componentes principais, envolvendo aspectos comportamentais e físicos. As curvas da Teoria de Resposta ao Item mostraram que todas as perguntas apresentam características discriminatórias, apontando para a adequação da versão brasileira proposta. Conclusão: A versão brasileira mostrou-se válida e confiável para aferir a qualidade de vida de indivíduos com obesidade, possibilitando desenvolver estratégias de intervenção, planejamento e execução de ações nos serviços e na política pública de saúde.

ABSTRACT: Objective: To perform a cross-cultural adaptation and validation in the Brazilian cultural context of questionnaire Patient-Reported Outcomes in Obesity (PROS). Methods: The cross-cultural adaptation process involved the translation from original English language into Brazilian Portuguese by two qualified and independent translators. The back-translation was performed by two English language teachers who were native speakers, without any medical knowledge of the original scale. An expert committee was created with researchers to assess semantic, idiomatic, experiential and conceptual equivalence. The pre-test of the Brazilian version, named PROS-Br, was carried out with ten adults with obesity. To assess the psychometric properties of the instrument, a cross-sectional epidemiological study was carried out. The population consisted of 120 Brazilian adults with obesity who went to the appointment at a school-clinic. The Item Response Theory and Factor Analysis with Principal Component Extraction was used for the psychometrics analysis. To measure reliability, the α-Cronbach indicator was used. Results: In the reliability analysis, α-Cronbach was 0.82. Two factors explained 58.3% of the total variance in the principal component analysis, involving behavioral and physical aspects. Item Response Theory curves showed that all questions have discriminatory characteristics, pointing to the adequacy of the proposed version. Conclusion: The Brazilian version was proven valid and reliable to measure the quality of life of individuals with obesity, allowing one to develop intervention strategies, plan and execute actions at services and for public health policies.

https://doi.org/10.1590/1980-549720220015.2

14.

Adaptação transcultural do questionário Patient-Reported Outcomes in Obesity (PROS) para utilização no Brasil
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Traebert, Jefferson

; Rodrigues, Michael Douglas

; Chaves, Manuella Souto

; Moritz, Nicole Morem Pilau

; Nunes, Rodrigo Dias

; Cremona-Parma, Gabriel Oscar

; Traebert, Eliane

Revista Brasileira de Epidemiologia

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2022, Volume 25 elocation e220015

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720220015.2

15.

Breathing and Cardiovascular Patterns: What can we Learn from Respiratory Exercises? Patterns Exercises
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Rodrigues, Gabriel Dias

International Journal of Cardiovascular Sciences

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Dez 2021, Volume 34 Nº 6 Páginas 732 - 733

Resumo: En | Texto: En | PDF: En

https://doi.org/10.36660/ijcs.20210191

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