Abstract Objective Eclampsia is a hypertensive disorder that occurs during pregnancy and can lead to death. The literature has gaps by not providing comprehensive data on the epidemiology of the disease, restricting analysis to limited temporal intervals and geographical locations. This study aims to characterize the epidemiological profile of women who died from eclampsia in Brazil from 2000 to 2021. Methods The maternal mortality data were obtained from the Sistema de Informações sobre Mortalidade, with the following variables of interest selected: “Federative Unit,” “Year,” “Age Range,” “Race/Color,” and “Education Level.” The collection of the number of live births for data normalization was conducted in the Sistema de Informações sobre Nascidos Vivos. Statistical analyses were performed using GraphPad Prism, calculating odds ratio for variables and fixing number of deaths per 100,000 live births for calculating maternal mortality ratio (MMR). Results There was a downward trend in maternal mortality rate during the study period. Maranhão stood out as the federative unit with the highest MMR (17 deaths per 100.000 live births). Mothers aged between 40 and 49 years (OR = 3.55, CI: 3.11–4.05) presents higher MMR. Additionally, black women showed the highest MMR (OR = 4.67, CI: 4.18–5.22), as well as mothers with no educational background (OR = 5.83, CI: 4.82–7.06). Conclusion The epidemiological profile studied is predominantly composed of mothers with little or no formal education, self-declared as Black, residing in needy states and with advanced aged. These data are useful for formulating public policies aimed at combating the issue. death disease locations 200 2021 Mortalidade selected Federative Unit, Unit Year, Year “Year, Age Range, Range Race/Color, RaceColor Race Color “Race/Color, Education Level. Level Vivos Prism 100000 100 000 100,00 . (MMR) period 17 (1 100.00 births. births) 4 OR 355 3 55 3.55 CI 3.11–4.05 311405 11 05 Additionally 467 67 4.67 4.18–5.22, 418522 4.18–5.22 , 18 5 22 4.18–5.22) 583 83 5.83 4.82–7.06. 482706 4.82–7.06 82 7 06 4.82–7.06) education selfdeclared self declared Black issue 20 202 “Year Race/Color “Race/Color 10000 10 00 100,0 (MMR 1 ( 100.0 35 3.5 3.11–4.0 31140 0 46 6 4.6 41852 4.18–5.2 2 58 8 5.8 48270 4.82–7.0 1000 100, 100. 3. 3.11–4. 3114 4. 4185 4.18–5. 5. 4827 4.82–7. 3.11–4 311 418 4.18–5 482 4.82–7 3.11– 31 41 4.18– 48 4.82– 3.11 4.18 4.82 3.1 4.1 4.8

Abstract The use of computational simulation techniques is an important tool for the coffee harvesting issues, particularly the finite element method. The method is widely used in the structural analysis of agricultural machinery, as well as in the analysis of the stresses and vibrations of coffee branches and peduncles during the harvesting process. The present study aimed to develop three-dimensional finite element models of the plagiotropic branches of the Catuaí Vermelho variety of Arabica coffee in different positions along the orthotropic branches of the plant; considering high-fidelity models. Additionally, by considering the branches’ experimental properties (physical-mechanical), the natural frequencies and vibration modes of the branches were determined by means of computer simulations. First, the geometric properties of the coffee branches were obtained by means of two images taken using a professional camera to obtain the input data of the virtual simulation. For the mechanical properties, it was used a semi-analytical digital scale, to obtain the mass of the specimens. The modulus of elasticity was determined using a universal testing machine. The variability in the simulated natural frequencies could be identified, which was on the order of 30% for the first frequency, regardless of the position of the branch in the plant. These values were lower for the other frequencies. Linear regression fits showed a coefficient of determination, and correlation tests were used to verify the relationship between the values obtained numerically and experimentally, which were validated by using experimental data using the modal analysis techniques. issues machinery process threedimensional three dimensional plant highfidelity high fidelity Additionally physicalmechanical, physicalmechanical physical , (physical-mechanical) simulations First semianalytical semi analytical scale specimens machine identified 30 frequency determination experimentally (physical-mechanical 3

ABSTRACT Objective To identify higher order aberrometry changes in different degrees of keratoconus. Methods Cross-sectional, retrospective, observational study. Fifty-four patients (108 eyes) diagnosed with keratoconus by the same corneal specialist using the Belin/Ambrósio Enhanced Ectasia ABCD criteria were analyzed, using the Pentacam® HR 70900 tomograph (Oculus Wetzlar, Germany). In addition, qualitative and quantitative analysis of higher order aberrations in these patients was performed using the OPD-Scan III-NIDEK. Results Through the evaluation of both eyes of the patients according to the criteria of Benin Ambrósio, the presence of KCN was verified in 34 patients. Furthermore, through statistical analysis, a direct relationship was found between posterior asphericity and the development of KCN; p<0.001 (reference: p<0.05). Through the analysis of the OPD scan, the main higher order aberrations found in patients with KCN were Coma, Trefoil and Spherical Aberration (AE). Conclusion The posterior curvature radius is the first variable to change with the development of the KCN, which is noticeable in the analysis of posterior asphericity in Pentacam. In addition, alterations in pachymetry and posterior asphericity directly influence the development of higher order aberrations in patients with KCN. Crosssectional, Crosssectional Cross sectional, sectional Cross-sectional retrospective study Fiftyfour Fifty four 108 (10 BelinAmbrósio Belin Ambrósio analyzed Pentacam 7090 Oculus Wetzlar Germany. Germany . Germany) addition OPDScan Scan IIINIDEK. IIINIDEK III NIDEK. NIDEK III-NIDEK 3 Furthermore p0001 p 0 001 p<0.00 reference (reference p<0.05. p005 p<0.05 05 p<0.05) scan Coma AE. AE (AE) 10 (1 709 p000 00 p<0.0 p00 (AE 1 ( 70 p<0. p0 7 p<0 p<

RESUMO Objetivo Identificar alterações de aberrometria de alta ordem em diferentes graus de ceratocone. Métodos Estudo transversal, retrospectivo, observacional. Foram analisados 54 pacientes (108 olhos) diagnosticados com ceratocone pelo mesmo especialista em córnea por meio dos critérios ABCD de Belin/Ambrósio Enhanced Ectasia, utilizando-se o tomógrafo Pentacam® HR 70900 (Oculus Wetzlar, Alemanha). Além disso, foram feitas análises qualitativa e quantitativa das aberrações de alta ordem desses mesmos pacientes por meio do OPD-Scan III-NIDEK. Resultados Por meio da avaliação de ambos os olhos dos pacientes com os critérios de Belin-Ambrósio, constatou-se presença de ceratocone em 34 pacientes. Ademais, por meio da análise estatística, constatou-se relação direta entre a asfericidade posterior e o desenvolvimento do ceratocone, com p<0,001 (referência: p<0,05). Por meio da análise do OPD-Scan III-NIDEK, as principais aberrações de alta ordem encontradas nos pacientes com ceratocone foram coma, trefoil e aberração esférica. Conclusão O raio da curvatura posterior é a primeira variável a se alterar com o desenvolvimento do ceratocone, o que se faz perceptível na análise da asfericidade posterior por meio o Pentacam®. Além disso, a alteração da paquimetria e da asfericidade posterior influencia diretamente o desenvolvimento de aberrações de alta ordem em pacientes com ceratocone. transversal retrospectivo observacional 5 108 (10 BelinAmbrósio Belin Ambrósio Ectasia utilizandose utilizando Pentacam 7090 Oculus Wetzlar Alemanha. Alemanha . Alemanha) disso OPDScan OPD Scan IIINIDEK. IIINIDEK III NIDEK. NIDEK III-NIDEK BelinAmbrósio, Ambrósio, Belin-Ambrósio constatouse constatou 3 Ademais estatística p0001 p 0 001 p<0,00 referência (referência p<0,05. p005 p<0,05 05 p<0,05) IIINIDEK, NIDEK, coma esférica 10 (1 709 p000 00 p<0,0 p00 1 ( 70 p<0, p0 7 p<0 p<

RESUMEN Objetivos: comparar la prevalencia de lactancia materna exclusiva versus alimentación artificial en recién nacidos de madres con COVID-19. Métodos: revisión sistemática de prevalencia, según JBI. Búsquedas en las bases de datos PubMed®, Embase, CINAHL, LILACS y Web of Science™ en agosto de 2021. Se seleccionaron estudios transversales, longitudinales o de cohortes, sin limitaciones de idioma y tiempo que mostraran prevalencia de lactancia materna o que permitieran calcular. Resultados: se analizaron 15 artículos publicados en 2020 y 2021, de cohorte (60%) o transversal (40%). El promedio de lactancia materna exclusiva en madres con COVID-19 fue 56,76% (IC=39,90-72,88), y lactancia artificial, 43,23% (IC = 30,99 – 55,88), sin diferencias estadísticamente significativas. Conclusiones: a pesar de las recomendaciones de mantener la lactancia materna, hubo una reducción a nivel mundial, en comparación con períodos previos a la pandemia. Con los avances de la ciencia, estas tasas han mejorado, mostrando el impacto de la evidencia en las prácticas. Como limitaciones se citan las fuentes del estudio. Se recomienda realizar nuevos estudios. Registro PROSPERO CRD42021234486. Objetivos COVID19. COVID19 COVID 19. 19 Métodos JBI PubMed PubMed® Embase CINAHL Science 2021 transversales cohortes calcular Resultados 1 202 60% 60 (60% 40%. 40 40% . (40%) COVID-1 5676 56 76 56,76 IC=39,9072,88, IC39907288 IC IC=39,90 72,88 , 39 90 72 88 (IC=39,90-72,88) 4323 43 23 43,23 3099 30 99 30,9 55,88, 5588 55,88 55 55,88) significativas Conclusiones mundial pandemia ciencia mejorado prácticas estudio CRD42021234486 CRD COVID1 20 6 (60 4 (40% COVID- 567 5 7 56,7 9072 IC=39,9072,88 IC3990728 IC3990 IC=39,9 7288 72,8 3 9 8 (IC=39,90-72,88 432 2 43,2 309 30, 558 55,8 CRD4202123448 (6 (40 56, 907 IC=39,9072,8 IC399072 IC399 IC=39, 728 72, (IC=39,90-72,8 43, 55, CRD420212344 ( (4 IC=39,9072, IC39907 IC39 IC=39 (IC=39,90-72, CRD42021234 IC=39,9072 IC3 IC=3 (IC=39,90-72 CRD4202123 IC=39,907 IC= (IC=39,90-7 CRD420212 (IC=39,90- CRD42021 (IC=39,90 CRD4202 (IC=39,9 CRD420 (IC=39, CRD42 (IC=39 CRD4 (IC=3 (IC=

ABSTRACT Objectives: to compare exclusive breastfeeding prevalence versus artificial feeding in newborns of mothers with COVID-19. Methods: a systematic review of prevalence, according to JBI. Searches in PubMed®, Embase, CINAHL, LILACS and Web of Science™ databases in August 2021. Cross-sectional, longitudinal or cohort studies were selected, without language and time limitations that showed breastfeeding prevalence or that allowed calculation. Results: fifteen articles published in 2020 and 2021, cohort (60%) or cross-sectional (40%) were analyzed. The average of exclusive breastfeeding in mothers with COVID-19 was 56.76% (CI=39.90–72.88), and artificial breastfeeding, 43.23% (CI = 30.99 – 55.88), without statistically significant differences. Conclusions: despite the recommendations for maintaining breastfeeding, there was a reduction worldwide, when compared to periods prior to the pandemic. With advances in science, these rates have improved, showing the impact of evidence on practices. As limitations, study sources are cited. It is recommended to carry out new studies. PROSPERO registration CRD42021234486. Objectives COVID19. COVID19 COVID 19. 19 Methods JBI PubMed PubMed® Embase CINAHL Science 2021 Crosssectional, Crosssectional Cross sectional, sectional Cross-sectional selected calculation Results 202 60% 60 (60% crosssectional cross 40% 40 (40% analyzed COVID-1 5676 56 76 56.76 CI=39.90–72.88, CI39907288 CI CI=39.90–72.88 , 39 90 72 88 (CI=39.90–72.88) 4323 43 23 43.23 3099 30 99 30.9 55.88, 5588 55.88 55 55.88) differences Conclusions worldwide pandemic science improved practices cited CRD42021234486 CRD COVID1 1 20 6 (60 4 (40 COVID- 567 5 7 56.7 CI3990728 CI=39.90–72.8 3 9 8 (CI=39.90–72.88 432 2 43.2 309 30. 558 55.8 CRD4202123448 (6 (4 56. CI399072 CI=39.90–72. (CI=39.90–72.8 43. 55. CRD420212344 ( CI39907 CI=39.90–72 (CI=39.90–72. CRD42021234 CI3990 CI=39.90–7 (CI=39.90–72 CRD4202123 CI399 CI=39.90– (CI=39.90–7 CRD420212 CI39 CI=39.90 (CI=39.90– CRD42021 CI3 CI=39.9 (CI=39.90 CRD4202 CI=39. (CI=39.9 CRD420 CI=39 (CI=39. CRD42 CI=3 (CI=39 CRD4 CI= (CI=3 (CI=

RESUMO Objetivos: comparar as prevalências de aleitamento materno exclusivo versus aleitamento artificial em recém-nascidos de mães com COVID-19. Métodos: revisão sistemática de prevalência, segundo JBI. Buscas nas bases PubMed®, Embase, CINAHL, LILACS e Web of Science™ em agosto de 2021. Selecionados estudos transversais, longitudinais ou coortes, sem limitação de idioma e tempo que apresentavam prevalência de aleitamento materno ou que permitissem o cálculo. Resultados: 15 artigos publicados em 2020 e 2021, coortes (60%) ou transversais (40%) foram analisados. A média de aleitamento materno exclusivo em mães com COVID-19 foi 56,76% (IC=39,90–72,88), e artificial, de 43,23% (IC = 30,99 – 55,88), sem diferenças estatisticamente significantes. Conclusões: apesar das recomendações para a manutenção do aleitamento materno, houve redução mundialmente, quando comparados à períodos anteriores à pandemia. Com avanços da ciência, esses índices têm melhorado, mostrando o impacto das evidências nas práticas. Como limitações, citam-se fontes dos estudos. Recomenda-se realização de novos estudos. Registro PROSPERO CRD42021234486. Objetivos recémnascidos recém nascidos COVID19. COVID19 COVID 19. 19 Métodos JBI PubMed PubMed® Embase CINAHL Science 2021 cálculo Resultados 1 202 60% 60 (60% 40% 40 (40% analisados COVID-1 5676 56 76 56,76 IC=39,90–72,88, IC39907288 IC IC=39,90–72,88 , 39 90 72 88 (IC=39,90–72,88) 4323 43 23 43,23 3099 30 99 30,9 55,88, 5588 55,88 55 55,88) significantes Conclusões mundialmente pandemia ciência melhorado práticas limitações citamse citam se Recomendase Recomenda CRD42021234486 CRD COVID1 20 6 (60 4 (40 COVID- 567 5 7 56,7 IC3990728 IC=39,90–72,8 3 9 8 (IC=39,90–72,88 432 2 43,2 309 30, 558 55,8 CRD4202123448 (6 (4 56, IC399072 IC=39,90–72, (IC=39,90–72,8 43, 55, CRD420212344 ( IC39907 IC=39,90–72 (IC=39,90–72, CRD42021234 IC3990 IC=39,90–7 (IC=39,90–72 CRD4202123 IC399 IC=39,90– (IC=39,90–7 CRD420212 IC39 IC=39,90 (IC=39,90– CRD42021 IC3 IC=39,9 (IC=39,90 CRD4202 IC=39, (IC=39,9 CRD420 IC=39 (IC=39, CRD42 IC=3 (IC=39 CRD4 IC= (IC=3 (IC=

RESUMEN Objetivo: comparar la efectividad de diferentes métodos diagnósticos para estimar la pérdida de volumen sanguíneo posparto. Métodos: revisión sistemática de efectividad según PRISMA y Protocolo JBI. Búsquedas en bases de datos: PubMed/MEDLINE, LILACS, Scopus, Embase, Web of Science y CINAHL, con el descriptor “Postpartum Hemorrhage” asociado a la palabra clave “Quantification of Blood Loss”. Los datos extraídos tabulados fueron presentados en metasíntesis y metanálisis se aplicaron a los datos cuantitativos. Para evaluar el riesgo de sesgo, se aplicaron las herramientas de evaluación de JBI. Resultados: se incluyeron 14 estudios, publicados entre 2006 y 2021. La cuantificación de pérdida por cualquier método fue superior a la estimación visual y es muy recomendable, sin embargo, la alta heterogeneidad de los estudios no permitió estimar esta asociación. Conclusión: la alta heterogeneidad de los estudios, con probable margen de error dado el descontrol de los factores, indica la necesidad de más estudios, sin embargo la cuantificación demostró ser efectiva en relación a la estimación visual. Registro PRÓSPERO CRD 42021234486. Objetivo posparto Métodos JBI PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE LILACS Scopus Embase CINAHL Postpartum Hemorrhage Quantification Loss. Loss . Loss” cuantitativos sesgo Resultados 1 200 2021 recomendable asociación Conclusión factores 42021234486 20 202 4202123448 2 420212344 42021234 4202123 420212 42021 4202 420 42 4

ABSTRACT Objective: to compare the effectiveness of different diagnostic methods to estimate postpartum blood volume loss. Methods: a systematic review of effectiveness according to PRISMA and JBI Protocol. Searches in PubMed/MEDLINE, LILACS, Scopus, Embase, Web of Science and CINAHL, with descriptor “Postpartum Hemorrhage” associated with keyword “Quantification of Blood Loss”. Tabulated extracted data, presented in metasynthesis and meta-analysis was applied to quantitative data. To assess risk of bias, JBI Appraisal Tools were applied. Results: fourteen studies were included, published between 2006 and 2021. Quantification of loss by any method was superior to visual estimation and is highly recommended, however the studies’ high heterogeneity did not allow estimating this association. Conclusion: the studies’ high heterogeneity, with a probable margin of error given the uncontrolled factors, indicates the need for further studies, however quantification proved to be effective in relation to visual estimate. PROSPERO registration CRD 42021234486. Objective Methods Protocol PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE LILACS Scopus Embase CINAHL Postpartum Hemorrhage Loss. Loss . Loss” data metaanalysis meta analysis bias Results included 200 2021 recommended association Conclusion factors 42021234486 20 202 4202123448 2 420212344 42021234 4202123 420212 42021 4202 420 42 4

RESUMO Objetivo: comparar a efetividade de diferentes métodos diagnósticos para estimar a perda volêmica sanguínea pós-parto. Métodos: revisão sistemática de efetividade, de acordo com protocolo PRISMA e JBI. Buscas nas bases PubMed/MEDLINE, LILACS, Scopus, Embase, Web of Science e CINAHL, com o descritor “Postpartum Hemorrhage” associado à palavra-chave “Quantification of Blood Loss”. Dados extraídos tabulados, apresentados em metassíntese, e aplicou-se metanálise para dados quantitativos. Para avaliar o risco de viés, aplicou-se o JBI Appraisal Tools. Resultados: incluídos 14 estudos, publicados entre 2006 e 2021. A quantificação da perda por qualquer método apresentou superioridade em relação à estimativa visual, sendo altamente recomendada, porém a alta heterogeneidade dos estudos não permitiu estimar essa associação. Conclusão: a alta heterogeneidade dos estudos, com provável margem de erro dado aos fatores não controlados, indica a necessidade de realização de novos estudos, contudo a quantificação se mostrou efetiva em relação à estimativa visual. Registro PROSPERO CRD 42021234486. Objetivo pósparto. pósparto pós parto. parto pós-parto Métodos PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE LILACS Scopus Embase CINAHL Postpartum Hemorrhage palavrachave palavra chave Quantification Loss. Loss . Loss” tabulados metassíntese aplicouse aplicou quantitativos viés Tools Resultados 1 200 2021 visual recomendada associação Conclusão controlados 42021234486 20 202 4202123448 2 420212344 42021234 4202123 420212 42021 4202 420 42 4

Resumen Este estudio teórico trata la bioética en el sentido de promover y garantizar la dignidad del paciente de forma segura, que acepte su toma de decisiones, siguiendo normas y protocolos que garanticen el cumplimiento de esa voluntad, además de brindar seguridad al equipo de atención. La falta de consenso en el ámbito legal respecto a normativa para la elaboración de un modelo de directivas de voluntad produce inseguridad en los profesionales de la salud involucrados, familiares y pacientes. La garantía de este derecho, además de la regulación legal, requiere que los profesionales conozcan el tema para orientar e informar correctamente a sus pacientes. No basta con garantizar al individuo el derecho a expresar su voluntad, sino que también es necesario la certeza de que esta se cumplirá. Son necesarios más estudios para ampliar las discusiones sobre el tema, con énfasis en el contexto brasileño. segura decisiones atención involucrados pacientes cumplirá brasileño

Abstract This theoretical study discusses bioethics in the sense of safely promoting and ensuring the patients’ dignity, respectful of their decision making, following regulations and protocols that help fulfill this will and bring safety to the care team. The lack of clear and consensual legal regulations on how to elaborate an advance directive generates uncertainty among healthcare providers, patients and their families. Beyond legal standardization, professionals must also have full knowledge on the topic to correctly guide and inform their patients, thus guaranteeing this right. But ensuring the right to express one’s will is not enough—one must be assured that such whishes will be fulfilled. Further and broader discussions on this topic anchored on the Brazilian reality are needed. dignity making team providers families standardization ones one s enoughone enough fulfilled needed

Resumo Este estudo teórico discorre sobre a bioética no sentido de promover e assegurar a dignidade do paciente de uma forma segura, que obedeça a sua tomada de decisão, seguindo normativas e protocolos que garantam o cumprimento dessa vontade, e trazendo também segurança para equipe assistencial. A ausência de consenso no meio jurídico, por falta de regulamentações que explicitem as regras para a elaboração de um modelo de diretivas de vontade, gera insegurança nos profissionais de saúde envolvidos, familiares e paciente. Para garantir esse direito, além da normatização jurídica, é necessário que os profissionais tenham pleno conhecimento do assunto, a fim de orientar e informar corretamente seus pacientes. Não basta assegurar ao indivíduo o direito de manifestar sua vontade, é preciso ainda a certeza de que esta será cumprida. Há a necessidade de ampliar discussões acerca da temática, com ênfase na realidade brasileira. segura decisão vontade assistencial jurídico envolvidos jurídica assunto pacientes cumprida temática brasileira

ABSTRACT Background: Domestic pigeons carry pathogens in their droppings, posing a potential public health problem. Methods: The phenotypic and genotypic antimicrobial resistances of Staphylococcus aureus and Enterococcus faecium in the feces of urban pigeons near hospitals with intensive care units were measured. Results: Twenty-nine samples showed Enterococcus growth, whereas one was positive for S. aureus. The S. aureus isolate was sensitive to the antibiotics tested via antibiogram, however resistance genes were identified. E. faecium isolates showed phenotypic resistance to gentamicin, erythromycin, and ciprofloxacin. Conclusions: Antimicrobial profiles harmful to health were demonstrated in bacterial pathogens isolated from the external environment of hospitals.

RESUMO: Objetivo: relacionar o conhecimento, a prática e os impedimentos do autocuidado com os pés em pessoas com Diabetes Mellitus Tipo 2 conforme sexo e escolaridade. Método: estudo transversal analítico, com 102 usuários de 4 unidades básicas de cidade interiorana do Piauí, Brasil. Coletaram-se dados socioeconômicos e clínicos, entre dezembro de 2018 a julho de 2019, analisados descritivamente por meio do teste de Qui-quadrado. Resultados: as mulheres obtiveram maior conhecimento e prática de hidratação (p<0,001), secagem entre os dedos do pé no pós-banho (p=0,020), hidratação dos pés com cremes/óleos hidrantes nos calcanhares (p<0,001), hidratação na planta do pé (p=0,003) e uso de calçados macios e fechados (p=0,001); uso frequente de meias pelos homens (p<0,001) e de algodão (p<0,001). Houve associação entre o nível de escolaridade e o uso de salto >5cm (p=0,001) e <5cm (p<0,001). Conclusão: espera-se que este estudo permita uma nova forma de abordagem, visando à aquisição e aperfeiçoamento do autocuidado.

ABSTRACT Objective: To relate knowledge, practice and barriers of diabetic foot self-care among people with Type 2 Diabetes Mellitus, according to gender and education. Method: Analytical cross-sectional study with 102 users of 4 basic units in the inland of the state of Piauí, Brazil. Socioeconomic and clinical data were collected between December 2018 and July 2019. Descriptive analysis was performed with the use of the Chi-square test. Results: Women showed greater knowledge and practice of moisturizing (p<0.001), drying between the toes after bathing (p=0.020), foot hydration with moisturizing creams/oils on the heels (p<0.001), hydration on the sole of the foot (p=0.003) and use of soft and closed-toed shoes (p=0.001); there was frequent use of socks by men (p<0.001) and they were mostly made of cotton (p<0.001). There was an association between educational level and the use of shoes with heels >5cm (p=0.001) and <5cm (p<0.001). Conclusion: It is hoped that this study will allow a new type of approach aimed to the improvement of diabetic foot self-care.

RESUMEN Objetivo: relacionar el conocimiento, la práctica y los impedimentos del autocuidado de los pies en personas con Diabetes Mellitus Tipo 2, de acuerdo con sexo y nivel de estudios. Método: estudio transversal y analítico realizado con 102 usuarios de 4 unidades básicas de una ciudad del interior de Piauí, Brasil. Se recolectaron datos sociodemográficos y clínicos entre diciembre de 2018 y julio de 2019, y se los analizó en forma descriptiva por medio de la prueba de chi-cuadrado. Resultados: las mujeres presentaron mayor conocimiento y práctica en las siguientes acciones de autocuidado: hidratación (p<0,001), secado del espacio entre los dedos de los pies después de bañarse (p=0,020), hidratación de los pies con cremas/aceites hidrantes en los talones (p<0,001), hidratación de la planta de los pies (p=0,003) y uso de calzado macizo y cerrado (p=0,001); en los hombres se observó uso frecuente de calcetines (p<0,001) y medias de algodón (p<0,001). Se registró una asociación entre nivel de estudios y uso de tacones de más de 5 cm (p=0,001) y menos de 5 cm (p<0,001). Conclusión: se espera que este estudio haga posible una nueva modalidad de enfoque, con vistas a adquirir y perfeccionar acciones de autocuidado.

Abstract The effect of high dietary lipid on the meat quality parameters of shoulder meat adult goats in raw meat and during curing and smoking was evaluated by classical and multivariate approaches. The animals were divided into two groups of different finishing strategies: without whole full-fat linseed (WFFLG, n = 9) and whole full-fat linseed (FFLG, n = 9), with diets containing an ether extract content of 2.7% and 6.9%, respectively. The physicochemical attributes did not vary according to the experimental diets in raw meat. The colorimetric parameters and pH varied during curing and smoking. Through multivariate analysis the first two principal components (PC), it was possible to identified variables were highly importance the total variation (L*, a*, b*, C*, h*, and fat content) in raw meat and smoking. The fat content and color b* presented the highest scores for importance of the variable in the projection. Lipid supplementation of adult goats did not influence the quality parameters physicochemical of the raw shoulder meat. However, after curing and smoking there was a significant effect of diet on Hue angle (h*).

RESUMO Objetivo: Avaliar sensibilidade do volume corneano, asfericidade e índice D para o diagnóstico precoce de ceratocone. Métodos: Estudo transversal analítico, realizado entre dezembro de 2018 e outubro de 2020, no qual foram analisados os prontuários de 39 pacientes (78 olhos) diagnosticados com ceratocone por um único subespecialista em córnea, por meio dos critérios de Belin/Ambrosio Enhanced Ectasia. Os dados coletados foram: asfericidade anterior, asfericidade posterior, índice D e suas frações (Da, Db, Dt, Dp e Df). Os dados foram digitados e manipulados em Excel, para posterior tratamento utilizando o programa Statistical Package for Social Science do Windows, versão 21.0. As variáveis categóricas foram apresentadas como valor absoluto e percentual. Variáveis contínuas foram apresentadas como média ± desvio-padrão e mediana (intervalo de confiança de 95%). Resultados: Foram analisados 78 olhos, com idade média de 28,2±5,8 anos e porcentagem entre o sexo feminino e masculino de 59,0% e 41,0%, respectivamente. O índice D apresentou estreita relação com sua fração Db nos casos iniciais de ceratocone, enquanto a fração Dt apresentou tal relação de forma reduzida. Conclusão: A correlação entre o índice D e sua fração Db sugere alterações precoces na elevação corneana posterior, colaborando para o diagnóstico de ceratocone subclínico.

ABSTRACT Objective: To assess sensitivity of corneal volume, corneal asphericity, and D index in early diagnosis of keratoconus. Methods: A cross-sectional analytical study, carried out between December 2018 and October 2020, which analyzed the medical records of 39 patients (78 eyes) diagnosed as keratoconus by a single corneal specialist, using the criteria of Belin-Ambrosio Enhanced Ectasia Display. The collected data were anterior asphericity, posterior asphericity, D index and its parameters (Da, Db, Dt, Dp and Df). The data were entered and handled in Excel, for later data treatment using the software Statistical Package for Social Science, version 21.0, for Windows. The categorical variables were presented as absolute value and percentages. The continuous variables were presented as mean±standard deviation, and median (95% of confidence interval). Results: We analyzed 78 eyes, mean age of 28.2±5.8 years, 59.0% of sample were female, and 41.0%, male. The D index showed a close relation to its Db parameter in the cases of keratoconus at early stage, while Dt parameter showed a reduced relation. Conclusion: The correlation between the D index and its Db parameter suggests early changes in the posterior corneal elevation, contributing to early diagnosis of subclinical keratoconus.

Abstract: BRS 500 B2RF is a high-yielding cotton cultivar with transgenic resistance to lepidopteran pests and tolerance to the herbicide glyphosate. Additionally, BRS 500 B2RF has resistance to Ramularia leaf spot and partial resistance to root-knot nematode. It represents an important contribution to sustainable cotton production in Brazil.

Resumo Objetivo: Observar o grau de concordância das variáveis analisadas entre os dispositivos IOL Master 500 e Pentacam AXL e descrever as medias Métodos: Foram analisados 35 prontuários, totalizando 61 olhos. Todos os pacientes se submeteram à avaliação biométrica nos dois dispositivos, no período de agosto de 2018 a agosto de 2019. Os dados coletados foram: idade, sexo, profundidade da câmara anterior, comprimento axial, K1, K2, poder dióptrico da LIO e alvo refracional. Resultados: As médias das variáveis analisadas entre os dispositivos de biométricos óptica em questão tiveram diferença estatisticamente significante (p<0,05). A regressão linear não apontou influência de nenhuma das variáveis da câmara anterior na diferença de valores do poder dióptrico da LIO e do alvo refracional entre os dispositivos. Conclusão: Não houve concordância estatística entre os dispositivos para as variáveis analisadas. Portanto, deve se evitar intercambiar o uso do Pentacam AXL com o IOL Master 500.

Abstract Objective: Observe the agreement between IOL Master 500 and Pentacam AXL and describe the averages. Methods: We analyzed 35 medical records, totaling 61 eyes. All patients underwent biometric evaluation on both devices from August 2018 to August 2019. The data collected were: age, gender, anterior chamber depth, axial length, K1, K2, biometrics and IOL target. Results: The averages of the variables analyzed between the optical biometric devices in question had a statistically significant difference (p <0.05). Linear regression showed no influence of any anterior chamber variables on the difference in biometrics and target values between the devices. Conclusion: There was no statistical agreement between the devices for the analyzed variables. Therefore, the interchange of Pentacam AXL with IOL Master 500 should be avoided.

ABSTRACT Objective: To know the clinical and epidemiological profile of TB / HIV in a priority municipality in Ceará. Method: Descriptive, epidemiological study, carried out through data collection. Collection performed in October 2019 for the years 2009 to 2019. The variables age group, sex, education, race, clinical form, case closure, antiretroviral therapy were used. The data were taken from SINAN (Information System for Notifiable Diseases), then tabulation was performed in the Tabwin software and later the records were transported to Excel. Results: 71 cases of TB-HIV co-infection were registered, which corresponds to 4.28% of the cases of tuberculosis in the municipality. From the analysis of the database about notified cases, in 2014 the largest proportion of cases (6.72%) was identified, followed by 2013 (6.43%). It is noteworthy that as of 2017, there is a decline in cases in the municipality. Conclusion: The results obtained indicated that, in the investigated period, 4.3% of individuals with TB had coinfection with HIV, which shows its epidemiological relevance as a comorbidity with a great impact on public health.

RESUMO Objetivo: Conhecer o perfil clínico-epidemiológico de TB/HIV em município prioritário do Ceará. Método Estudo descritivo, epidemiológico, realizado por meio de levantamento de dados. Coleta realizada em outubro de 2019 referente aos anos de 2009 a 2019. Foram utilizados as variáveis faixa etária, sexo, escolaridade, raça, forma clínica, encerramento do caso, terapia antirretroviral. Os dados foram retirados do SINAN (Sistema de Informação de Agravos de Notificação), em seguida foi realizada a tabulação no software Tabwin e posteriormente os registros foram transportados para o Excel. Resultados: Foram registrados 71 casos de coinfecção TB-HIV, que corresponde a 4,28% dos casos de Tuberculose no município. A partir da análise do banco de dados acerca dos casos notificados, em 2014 identificou-se o maior proporção de casos (6,72%), seguido do ano 2013(6,43%). Destaca-se que a partir de 2017, há um declínio de casos no município. Conclusão: Os resultados obtidos indicaram que, no período investigado, 4,3% dos indivíduos com TB apresentavam coinfecção com o HIV, o que evidencia sua relevância epidemiológica como uma comorbidade de grande impacto na saúde pública.

RESUMEN Objetivo: Conocer el perfil clínico-epidemiológico de TB / VIH en municipio prioridad de el Ceará. Método Estudio descriptivo, epidemiológico, realizado a través de la recolección de datos. Recolección realizada en octubre de 2019 para los años 2009 a 2019. Se utilizaron las variables grupo de edad, sexo, educación, raza, forma clínica, cierre de casos, terapia antirretroviral. Los datos fueron tomados de SINAN (Sistema de Información para Enfermedades de Notificación), la tabulación se realizó en el software Tabwin y luego los registros fueron transportados a Excel. Resultados: Se registraron 71 casos de coinfección TB-VIH, lo que corresponde al 4,28% de los casos de tuberculosis en el municipio. Del análisis de la base de datos sobre los casos notificados, en 2014 se identificó la mayor proporción de casos (6,72%), seguido del año 2013 (6,43%). Es de destacar que a partir de 2017, hay una disminución en los casos en el municipio. Conclusión Los resultados obtenidos indicaron que, durante el período investigado, el 4,3% de las personas con TB tuvieron coinfección con VIH, lo que muestra su relevancia epidemiológica como una comorbilidad con un gran impacto en la salud pública.

More than 18 million people in 188 countries have been diagnosed as having coronavirus disease (COVID-19), and COVID-19 has been responsible for more than 600,000 deaths worldwide. Brazil is now the second most affected country globally. Faced with this scenario, various public health measures and changes in the daily routines of hospitals were implemented to stop the pandemic. Patients with hepatocellular carcinoma (HCC) are at an increased risk for severe COVID-19 as they present with two major diseases: cancer and concomitant chronic liver disease. The COVID-19 pandemic can significantly impact the management of HCC patients from diagnosis to treatment strategies. These patients need special attention and assistance at this time, especially since treatment for tumors cannot be delayed in most cases. The aim of this guideline was to standardize the management of HCC patients during the COVID-19 pandemic. This document was developed, on the basis of the best evidence available, by a multidisciplinary team from Instituto do Câncer do Estado de São Paulo (ICESP), and Instituto Central of the Hospital das Clínicas da Universidade de São Paulo (HC-FMUSP), which are members of the São Paulo Clínicas Liver Cancer Group.

Resumo Objetivo: O dispositivo EX-PRESS é uma alternativa cirúrgica para o tratamento do GPAA. Descrever o comportamento da PIO antes e após a implantação do EX-PRESS, o tratamento farmacológico utilizado no período pré e pós-operatório e as complicações no primeiro ano do pós-operatório. Métodos: Estudo descritivo quantitativo com revisão de prontuários eletrônicos de um hospital particular de referência oftalmológica de Goiânia (GO) no período de 2013 a 2018. Amostra composta por 8 olhos com GPAA submetidos ao implante de EX-PRESS. Foram observadas variáveis: sexo, idade, olho operado, medicações antiglaucomatosas usadas, pressão intraocular pré e pós-operatória, e possíveis complicações. Resultados: No pré-operatório, todos os olhos usavam colírios antiglaucomatosos, 75% faziam uso simultâneo de 3 ou mais classes diferentes. Após 12 meses do EX-PRESS, apenas 12,5% usavam três ou mais colírios e 37,5% não usavam nenhum colírio. Em média, as PIO variaram de 18,63 (DP 9,38) mmHg no pré-operatório para 14,50 (DP 4,14) mmHg em 12 meses do pós-operatório. As complicações foram: hipotensão ocular, hipertensão ocular,afinamento de bolha conjuntival, bolha cística, obstrução parcial do EX-PRESS. Conclusão: A eficácia do EX-PRESS na redução da PIO foi verificada na amostra desse estudo. Concomitantemente, constatou-se diminuição considerável de medicações anti-glaucomatosas, e poucas complicações associadas.

Abstract Objective: The EX-PRESS device is a surgical alternative for the treatment of POAG. To describe the IOP behavior before and after the implantation of the EX-PRESS, the pharmacological treatment used in the pre and postoperative period and the complications in the first year of the postoperative period. Methods: A quantitative descriptive study with review of electronic medical records of a private ophthalmological reference hospital in Goiânia (GO) from 2013 to 2018. Sample composed of 8 eyes with POAG subjected to the EX-PRESS implant. We observed the variables: gender, age, operated eye, antiglaucomatous medications used, pre and postoperative intraocular pressure, and possible complications. Results: In the preoperative period, all eyes used antiglaucomatous drops, 75% used 3 or more different classes simultaneously. After 12 months of EX-PRESS, only 12.5% used three or more eye drops and 37.5% did not use any eye drops. On average, IOP varied from 18.63mmHg (SD 9.38) in the preoperative period to 14.50mmHg (SD 4.14) at 12 months postoperatively. Complications were: ocular hypotension, ocular hypertension; thinning of the conjunctival blister, cystic blister obstruction of the EX-PRESS. We resolved all coplications. Conclusion: The efficacy of EX-PRESS in IOP reduction was verified in the study. Concomitantly, there was a considerable decrease in anti-glaucomatous medications, and few associated complications.