RESUMO: O objetivo deste estudo retrospectivo foi avaliar o impacto da apresentação clínica da piometra na morbimortalidade das cadelas afetadas. Foram avaliados os registros clínicos de 47 cadelas tratadas cirurgicamente para piometra entre maio e dezembro de 2017. Os dados recolhidos na admissão foram analisados para classificar os animais quanto à apresentação clínica da piometra, presença de critérios da Síndrome da Resposta Inflamatória Sistêmica (SRIS) e disfunções orgânicas - cardiovascular, neurológica, renal e hemostática. Foi registrado o desfecho durante 14 dias. A mortalidade global foi de 13%. Piometra aberta e fechada foram identificadas em 62% (n= 29) e 38% (n= 18) respectivamente. SRIS esteve presente em 44 (94%) cadelas e 27 (57%) tiveram pelo menos uma disfunção orgânica. A disfunção mais prevalente foi a hemostática, seguida da neurológica, cardiovascular e renal. A apresentação clínica da piometra e a presença de SRIS não se correlacionaram entre si ou com presença de disfunção orgânica e mortalidade. No entanto, a quantidade de disfunções orgânicas (r=0.532, P=<0.001) e a presença das disfunções neurológica (r= -0.371; P=0.012) e renal (r=0.303; P=0.041) foram correlacionados com mortalidade. Assim, a identificação de disfunções orgânicas através do exame físico e análises laboratoriais de rotina mostrou-se mais eficaz na identificação e previsão de pacientes críticos do que os critérios de SRIS ou a apresentação clínica da doença. RESUMO afetadas 4 2017 (SRIS hemostática 1 dias 13 13% 62 n= n (n 29 38 18 respectivamente 94% 94 (94% 2 57% 57 (57% entanto r=0.532, r0532 r 0 532 (r=0.532 P=<0.001 P0001 P 001 r= (r 0.371 0371 371 -0.371 P=0.012 P0012 012 r=0.303 r0303 303 (r=0.303 P=0.041 P0041 041 Assim mostrouse mostrou doença 201 6 3 9 (94 5 (57 r=0.532 r053 53 (r=0.53 P=<0.00 P000 00 0.37 037 37 -0.37 P=0.01 P001 01 r=0.30 r030 30 (r=0.30 P=0.04 P004 04 20 (9 (5 r=0.53 r05 (r=0.5 P=<0.0 P00 0.3 03 -0.3 P=0.0 r=0.3 r03 (r=0.3 ( r=0.5 r0 (r=0. P=<0. P0 0. -0. P=0. r=0. (r=0 P=<0 -0 P=0 r=0 P=< P=

ABSTRACT: This retrospective study evaluated the impact of the clinical presentation of pyometra on the morbidity and mortality of the affected bitches. The medical records of 47 bitches surgically treated for pyometra between May and December 2017 were evaluated. The admission data were analyzed to classify the animals according to the clinical presentation of pyometra, presence of systemic inflammatory response syndrome (SIRS) and organic dysfunctions (cardiovascular, neurological, renal, and hemostatic). The outcomes were recorded for up to 14 days. The overall mortality rate was 13%. Open and closed pyometra were identified in 62% (n= 29) and 38% (n= 18) of the cases, respectively. The SIRS was present in 44 (94%) bitches, and 27 (57%) had at least one organ dysfunction. The most prevalent dysfunction was hemostatic, followed by neurological, cardiovascular, and renal dysfunction. The clinical presentation of pyometra and the presence of SIRS did not correlate with each other, or with the presence of organ dysfunction and mortality. However, cumulative organ dysfunction (r=0.532, P=<0.001) and the presence of neurological (r= -0.371; P=0.012) and renal dysfunction (r=0.303; P=0.041) were correlated with mortality. Thus, the identification of organ dysfunction through physical examination and routine laboratory analysis proved to be more effective in identifying and predicting the critically ill patients than the SIRS criteria or clinical presentation of the disease. ABSTRACT 4 201 (SIRS cardiovascular (cardiovascular hemostatic. hemostatic . hemostatic) 1 days 13 13% 62 n= n (n 29 38 18 cases respectively 94% 94 (94% 2 57% 57 (57% other However r=0.532, r0532 r 0 532 (r=0.532 P=<0.001 P0001 P 001 r= (r 0.371 0371 371 -0.371 P=0.012 P0012 012 r=0.303 r0303 303 (r=0.303 P=0.041 P0041 041 Thus disease 20 6 3 9 (94 5 (57 r=0.532 r053 53 (r=0.53 P=<0.00 P000 00 0.37 037 37 -0.37 P=0.01 P001 01 r=0.30 r030 30 (r=0.30 P=0.04 P004 04 (9 (5 r=0.53 r05 (r=0.5 P=<0.0 P00 0.3 03 -0.3 P=0.0 r=0.3 r03 (r=0.3 ( r=0.5 r0 (r=0. P=<0. P0 0. -0. P=0. r=0. (r=0 P=<0 -0 P=0 r=0 P=< - P=

ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,

Abstract Background Approximately 30 % of cardiac surgeries are conducted on women by median sternotomy, which often causes discomfort such as pain, affects quality of life, and delayed recovery compared with men. Breast size is related to operative wound complications, such as incisional pain, sternum dehiscence, and infection, which may affect hospital costs due to prolonged hospital stays. Objective To evaluate breast size and operative wound complications and the effect of breast support on the incidence of pain, infection, and quality of life in women after coronary artery bypass grafting. Method Women were randomly assigned to one of three groups: group A (surgical breast support), group B (ordinary breast support), and group C (no-support). Observations were taken daily between the second and seventh postoperative days and at 30, 60, and 180 days. Pain was assessed using the Short-Form 36 Health Survey (SF36) for quality of life and a verbal numerical scale. The authors used the nonparametric Kruskal-Wallis and Friedman tests to examine variance. The authors used the Pearson correlation coefficient or the Spearman correlation for correlations between variables. A multivariate study was conducted to evaluate the occurrence of infection, and the logistic regression model with “stepwise” variable selection was used. A linear regression model with the “stepwise” variable selection was also used for hospitalization. The authors used SPSS 17.0 software for Windows, with a significance level of p < 0.05. Results There was no difference in pain evaluation between the groups in 190 women (p > 0.05). When comparing quality of life, there was a statistically significant difference in the functional capacity domain at 30 and 60 days, with group A having the best functional capacity (p < 0.05). The larger the breast size, the longer the hospital stay (p < 0.001) and the higher the probability of infection (p = 0.032). Patients with a history of stroke had a 3.8 higher incidence of infection (p = 0.040). Conclusion The use of surgical support did not affect acute pain or sternal infection rate in the 6-month follow-up. However, it was effective in the functional capacity domain 30 days after surgery and maintained at 60 days. 3 sternotomy men dehiscence stays grafting support, , support) ordinary nosupport. nosupport . (no-support) 18 ShortForm Short Form SF36 SF (SF36 scale KruskalWallis Kruskal Wallis variance variables stepwise “stepwise hospitalization 170 17 0 17. Windows 005 05 0.05 19 0.05) 6 0.001 0001 001 0.032. 0032 0.032 032 0.032) 38 8 3. 0.040. 0040 0.040 040 0.040) 6month month followup. followup follow up. up follow-up However (no-support 1 SF3 (SF3 00 0.0 0.00 000 003 0.03 03 004 0.04 04 (SF 0.

RESUMO Seis novas espécies de Parmotrema (P. aristidesii, P. hypoflavum, P. marjorieanum, P. marlitonii, P. nelihondae e P. subcristiferum) e P. cristiferum, todas contendo ácido salazínico, foram coletadas da floresta amazônica em Mato Grosso, Brasil, (centro da América do Sul), e são descritas, ilustradas e comentadas usando a versão final do protocolo descritivo GEL (Grupo de Estudos Liquenológicos), cujas principais atualizações são descritas e explicadas. P (P aristidesii hypoflavum marjorieanum marlitonii subcristiferum cristiferum salazínico Grosso Brasil centro Sul, Sul , Sul) Grupo Liquenológicos, Liquenológicos Liquenológicos) explicadas

ABSTRACT Six new species of Parmotrema (P. aristidesii, P. hypoflavum, P. marjorieanum, P. marlitonii, P. nelihondae, and P. subcristiferum) and P. cristiferum, all containing salazinic acid, were collected from the Amazon rainforest in Mato Grosso State, Brazil, (Central South America), and are described, illustrated, and commented by using the ultimate version of the GEL (Lichenological Studies Group) descriptive protocol, that has explained its most important recent improvements. P (P aristidesii hypoflavum marjorieanum marlitonii nelihondae subcristiferum cristiferum acid State Brazil Central America, America , America) described illustrated Lichenological Group protocol improvements

RESUMO O objetivo do presente estudo foi comparar a autonomia funcional entre idosas sedentárias e idosas fisicamente ativas. Para este estudo qualitativo, a amostra foi dividida em grupo de sedentárias (GS; n= 28, idade 67,64± 7,73) e grupo de idosas fisicamente ativas (GFA; n= 28, idade 68,64± 8,40). A autonomia funcional foi avaliada através dos testes do Grupo de Desenvolvimento Latino-Americano para a Maturidade (GDLAM), composto de: caminhar 10m (C10m), levantar-se da posição sentada (LPS), levantar-se da posição de decúbito ventral (LPDV), levantar-se da cadeira e locomover-se pela casa (LCLC), teste de vestir e tirar uma camiseta (VTC) e o índice GDLAM. Na correlação dos grupos com os testes realizados, pôde-se observar que o GFA apresentou melhores valores nos testes do que o GS e que existiu diferença significativa (p< 0,05) entre os dois grupos nos testes de C10m, LPS, LPDV, LCLC e IG. Pode-se depreender que o GFA apresentou melhor nível de autonomia funcional quando comparado com o GS, corroborando com as recomendações científicas acerca dos efeitos benéficos da atividade física sobre a capacidade funcional.

ABSTRACT This research aimed to compare the functional autonomy between physically inactive and physically active elderly women. In this study, the sample was divided into one group of inactive elderly women (GI; n= 28, age 67,64± 7,73) and one group of physically active elderly women (GPA; n= 28, age 68,64± 8,40). The functional autonomy was evaluated through the tests of Latin-American Development Group for the Elderly (GDLAM), based on: walking 10 meters (W10m), getting up from a sitting position (SUSP), standing up from a lying position (SULP), stand up from a chair and walk straightaway (SUCWA), dress and undress T-shirt (DUT) and GDLAM Index (GI). In the correlation of the groups, it can be observed that GPA showed better values on tests than GS and the significative difference (p< 0,05) into groups on tests (W10m, SUSP, SULP, SUCWA and GI). It can be inferred that GPA showed a better level of functional autonomy than GI, confirming scientific recommendations about the benefic effects of physical activity on functional capacity.

RESUMO Este estudo comparou o treinamento de força, treinamento aeróbico e treinamento de resistência muscular, sobre a autonomia funcional e qualidade de vida de idosos. Participaram 133 sujeitos, divididos em quatro grupos, realizaram 16 semanas de treinamento de força, resistência muscular e aeróbico, além do grupo controle que não realizou nenhuma prática. Para avaliar a autonomia funcional foi utilizado o protocolo GDLAM e para qualidade de vida o questionário WHOQOL-OLD. Após a análise dos resultados, verificou-se que, apesar dos efeitos positivos para todos os grupos experimentais, o grupo força se mostrou mais eficiente na diminuição do tempo para execução dos testes da autonomia funcional (Δ% −22.5876, p< 0,0001). Para a qualidade de vida o mesmo grupo apresentou uma diferença significativa para o domínio 6 que trata da intimidade, elevando então a qualidade de vida geral dos indivíduos (Δ% 11.96531, p< 0,0001). Conclui-se que o treinamento de força apresentou maior índice de melhora na autonomia funcional e qualidade de vida dos idosos. Todavia seria imprudente descartar os efeitos positivos proporcionados pelos demais treinamentos analisados. Neste sentido, os achados deste estudo reforçam a prática regular e orientada de exercícios físicos de diferentes tipos para os idosos, sendo ferramenta importante e decisiva na manutenção e melhora das múltiplas variáveis de saúde.

ABSTRACT This study compared resistance training, aerobic training and muscular endurance training, on functional autonomy and quality of life of the elderly. The present study encompassed 133 participants, divided into four groups, who performed 16 weeks of resistance training, aerobic training and muscular endurance training, in addition to the control group that did not perform any practice. The GDLAM protocol was used to assess functional autonomy, and the WHOQOL-OLD questionnaire was used to assess the quality of life. After analysing the results, it was found that despite the positive effects for all experimental groups, the resistance training group was more efficient in reducing the time to perform functional autonomy tests (Δ% −22.5876, p< 0.0001). Regarding the quality of life, the same group presented a significant difference for domain 6, which deals with intimacy, raising the overall quality of life of individuals (Δ% 11.96531, p< 0.0001). It was concluded that resistance training showed a higher rate of improvement in functional autonomy and quality of life of the elderly. However, it would be imprudent to rule out the positive effects provided by the other training analysed. In this sense, the findings of this study reinforce the regular and oriented practice of physical exercises of different types for the elderly, being an important and decisive tool in the maintenance and improvement of multiple health variables.

There is no consensus on the most appropriate method for normalizing electromyography (EMG) signals from masticatory muscles during isotonic activity. Aim To analyze the best method for data processing of the EMG signal of the masticatory muscles during isotonic activity (non-habitual chewing), comparing raw data and different types of normalization. Methods This is a cross-sectional study. Women aged between 18 and 45 years were selected. Anthropometric data were collected (age, height, body mass index – BMI, masticatory preference) as well as EMG signal (root mean square – RMS) data for the anterior temporal and masseter bilaterally, and for the suprahyoid muscles, during isotonic (non-habitual chewing) and isometric tasks. EMG data were processed offline using Matlab® Software. The normalization of the EMG signal was carried out using the 2nd masticatory cycle, chosen at random, of the 20 cycles collected, the maximum RMS value, and the maximum voluntary contraction (MVC). To analyze the best method of data processing for the isotonic data, the coefficient of variation (CV) was calculated. Descriptive data analysis was adopted, using the mean and standard deviation. ANOVA with repeated measures was used to detect significant differences between the methods of normalization. Statistical significance was set at 5% (α<0.05). Results The final sample of this research was composed of 86 women. The volunteers presented an average age of 27.83±7.71 years and a mean BMI of 22.85±1.91 Kg/m2. Regarding masticatory preference, 73.25% reported the right side, and 26.75% the left side. Considering the comparison between the methods, the %CV measure of the 2nd cycle showed the lowest variation coefficient during biting for all the muscles from the raw data, RMS Max, and MVC (p=0.001, p=0.003, and p=0.001 respectively). Conclusion In conclusion, for non-habitual chewing activity, the results of this study recommend data processing using normalization with the second cycle during chewing. (EMG nonhabitual non habitual chewing, , crosssectional cross sectional 1 4 selected age, (age height preference root bilaterally tasks Matlab Software nd random 2 value MVC. . (MVC) CV (CV calculated adopted deviation 5 α<0.05. α005 α α<0.05 0 05 (α<0.05) 8 women 2783771 27 83 7 71 27.83±7.7 2285191 22 85 91 22.85±1.9 Kgm2 Kgm Kg m2 m Kg/m2 7325 73 25 73.25 side 2675 26 75 26.75 Max p=0.001, p0001 p 001 (p=0.001 p0003 003 p=0.003 p=0.00 respectively. respectively respectively) conclusion (MVC α00 α<0.0 (α<0.05 278377 27.83±7. 228519 9 22.85±1. Kg/m 732 73.2 267 26.7 p000 00 (p=0.00 p=0.0 α0 α<0. (α<0.0 27837 27.83±7 22851 22.85±1 73. 26. p00 (p=0.0 p=0. α<0 (α<0. 2783 27.83± 2285 22.85± p0 (p=0. p=0 α< (α<0 278 27.83 228 22.85 (p=0 p= (α< 27.8 22.8 (p= (α 27. 22. (p

Abstract This study aimed to evaluate the effect of endodontic sealer (ES) on bond strength (BS) of prefabricated or milled-CAD-CAM (computer-aided design and computer-aided manufacturing) glass-fiber-posts (GFP). Canals of 90 single-rooted teeth were prepared for filling by the single-cone technique with gutta-percha and one of the following ES: AH Plus (epoxy resin), Endofill (zinc-oxide and eugenol), and Bio-C Sealer (calcium-silicate). After post-space preparation, tooth-specimens were equally divided in half according to type of GFP to be used. In the half to receive milled-CAD-CAM posts, tooth specimens were molded with acrylic resin to obtain replicas. These were scanned to enable the laboratory to produce the milled-CAD-CAM GFPs (Fiber CAD Lab, Angelus) by the subtractive technique. The other half of samples received prefabricated GFPs (Exacto, Angelus) (n=15). The GFPs were cemented with dual-cure resin cement (Panavia F2.0, Kuraray). Each root was sectioned into two slices per root region (cervical, middle, apical) that were subjected to the push-out BS test, in a universal testing machine. Failure mode (FM) was classified by scores. The BS data were submitted to generalized linear model analyses, while FM was analyzed using the chi-square test (a=0.05). BS showed no significant difference among the three ES (p > 0.05). BS was significantly higher for prefabricated (mean 10.84 MPa) versus milled-CAD-CAM GFPs (mean 6.94 MPa) (p <0.0001), irrespective of ES. The majority showed mixed failures. It could be concluded that type of ES did not affect BS of GFPs to dentin, and prefabricated-GFPs had higher bond-strength than customized-milled-CAD-CAM GFPs. (ES (BS milledCADCAM milled CAM computeraided computer aided manufacturing glassfiberposts glass fiber posts GFP. . (GFP) 9 singlerooted single rooted singlecone cone guttapercha gutta percha epoxy resin, , resin) zincoxide zinc oxide eugenol, eugenol eugenol) BioC Bio C calciumsilicate. calciumsilicate calcium silicate (calcium-silicate) postspace post space preparation toothspecimens used replicas Fiber Lab Angelus Exacto, Exacto (Exacto n=15. n15 n n=15 15 (n=15) dualcure dual cure Panavia F20 F F2 0 F2.0 Kuraray. Kuraray Kuraray) cervical, cervical (cervical middle apical pushout push out machine (FM scores analyses chisquare chi square a=0.05. a005 a=0.05 05 (a=0.05) p 0.05. 005 0.05 0.05) mean 1084 10 84 10.8 MPa 694 6 94 6.9 <0.0001, 00001 <0.0001 0001 <0.0001) failures dentin prefabricatedGFPs bondstrength customizedmilledCADCAM customized (GFP (calcium-silicate n1 n=1 1 (n=15 F2. a00 a=0.0 (a=0.05 00 0.0 108 8 10. 69 6. 0000 <0.000 000 n= (n=1 a0 a=0. (a=0.0 0. <0.00 (n= a=0 (a=0. <0.0 (n a= (a=0 <0. (a= <0 (a <

Resumo Fundamento A Insuficiência Cardíaca é um importante problema de saúde pública, que leva à alta carga de sintomas físicos e psicológicos, apesar da terapia otimizada. Objetivo Avaliar primariamente o impacto de um Programa de Redução de Estresse, Meditação e Atenção plena na redução do estresse de pacientes com Insuficiência Cardíaca. Métodos Ensaio clínico randomizado e controlado que avaliou o impacto de um programa de redução de estresse comparado ao atendimento multidisciplinar convencional, em dois centros especializados no Brasil. O período de coleta de dados ocorreu entre abril e outubro de 2019. Um total de 38 pacientes foram alocados nos grupos de intervenção ou controle. A intervenção aconteceu ao longo de 8 semanas. O protocolo consistiu na avaliação das escalas de estresse percebido, depressão, qualidade de vida, ansiedade, atenção plena, qualidade do sono, teste de 6 minutos de caminhada e biomarcadores por um grupo cego, considerando um p-valor <0,05 como estatisticamente significativo. Resultados A intervenção resultou em redução significativa no estresse percebido de 22,8 ± 4,3 para 14,3 ± 3,8 pontos na escala de estresse percebido no grupo de intervenção vs. 23,9 ± 4,3 para 25,8 ± 5,4 no grupo controle (p-valor<0,001). Foi observada melhora significativa na qualidade de vida (p-valor=0,013), atenção plena (p-valor=0,041), qualidade do sono (p-valor<0,001) e no teste de 6 minutos de caminhada (p-valor=0,004) no grupo sob intervenção comparado com o controle. Conclusão O Programa de Redução de Estresse, Meditação e Atenção plena reduziu efetivamente o estresse percebido e melhorou desfechos clínicos em pacientes com Insuficiência Cardíaca. pública psicológicos otimizada Estresse convencional Brasil 2019 3 semanas depressão ansiedade cego pvalor p valor 005 0 05 <0,0 significativo 228 22 22, 43 4 4, 143 14 14, 3, vs 239 23 9 23, 258 25 25, 54 5 5, pvalor<0,001. pvalor0001 valor<0,001 . 001 pvalor=0,013, pvalor0013 valor=0,013 , 013 (p-valor=0,013) pvalor=0,041, pvalor0041 valor=0,041 041 (p-valor=0,041) pvalor<0,001 (p-valor<0,001 pvalor=0,004 pvalor0004 valor=0,004 004 (p-valor=0,004 201 00 <0, 2 1 pvalor000 valor0001 valor<0,00 pvalor=0,013 pvalor001 valor0013 valor=0,01 01 (p-valor=0,013 pvalor=0,041 pvalor004 valor0041 valor=0,04 04 (p-valor=0,041 pvalor<0,00 (p-valor<0,00 pvalor=0,00 valor0004 valor=0,00 (p-valor=0,00 20 <0 pvalor00 valor000 valor<0,0 pvalor=0,01 valor001 valor=0,0 (p-valor=0,01 pvalor=0,04 valor004 (p-valor=0,04 pvalor<0,0 (p-valor<0,0 pvalor=0,0 (p-valor=0,0 < pvalor0 valor00 valor<0, valor=0, pvalor<0, (p-valor<0, pvalor=0, (p-valor=0, valor0 valor<0 valor=0 pvalor<0 (p-valor<0 pvalor=0 (p-valor=0 valor< valor= pvalor< (p-valor< pvalor= (p-valor= (p-valor

Abstract Background Heart Failure is a significant public health problem leading to a high burden of physical and psychological symptoms despite optimized therapy. Objective To evaluate primarily the impact of a Stress Reduction, Meditation, and Mindfulness Program on stress reduction of patients with Heart Failure. Methods A randomized and controlled clinical trial assessed the effect of a stress reduction program compared to conventional multidisciplinary care in two specialized centers in Brazil. The data collection period took place between April and October 2019. Thirty-eight patients were included and allocated to the intervention or control groups. The intervention took place over 8 weeks. The protocol assessed the scales of perceived stress, depression, quality of life, anxiety, mindfulness, quality of sleep, a 6-minute walk test, and biomarkers analyzed by a blinded team, considering a p-value <0.05 statistically significant. Results The intervention resulted in a significant reduction in perceived stress from 22.8 ± 4.3 to 14.3 ± 3.8 points in the perceived stress scale-14 items in the intervention group vs. 23.9 ± 4.3 to 25.8 ± 5.4 in the control group (p-value<0.001). A significant improvement in quality of life (p-value=0.013), mindfulness (p-value=0.041), quality of sleep (p-value<0.001), and the 6-minute walk test (p-value=0.004) was also observed in the group under intervention in comparison with the control. Conclusion The Stress Reduction, Meditation, and Mindfulness Program effectively reduced perceived stress and improved clinical outcomes in patients with chronic Heart Failure. therapy Reduction Meditation Brazil 2019 Thirtyeight Thirty eight groups weeks depression anxiety 6minute minute 6 team pvalue p value 005 0 05 <0.0 228 22 22. 43 4 3 4. 143 14 14. 38 3. scale14 scale scale-1 vs 239 23 9 23. 258 25 25. 54 5 5. pvalue<0.001. pvalue0001 value<0.001 . 001 (p-value<0.001) pvalue=0.013, pvalue0013 value=0.013 , 013 (p-value=0.013) pvalue=0.041, pvalue0041 value=0.041 041 (p-value=0.041) pvalue<0.001, pvalue=0.004 pvalue0004 value=0.004 004 (p-value=0.004 201 00 <0. 2 1 scale1 scale- pvalue<0.001 pvalue000 value0001 value<0.00 (p-value<0.001 pvalue=0.013 pvalue001 value0013 value=0.01 01 (p-value=0.013 pvalue=0.041 pvalue004 value0041 value=0.04 04 (p-value=0.041 pvalue=0.00 value0004 value=0.00 (p-value=0.00 20 <0 pvalue<0.00 pvalue00 value000 value<0.0 (p-value<0.00 pvalue=0.01 value001 value=0.0 (p-value=0.01 pvalue=0.04 value004 (p-value=0.04 pvalue=0.0 (p-value=0.0 < pvalue<0.0 pvalue0 value00 value<0. (p-value<0.0 value=0. pvalue=0. (p-value=0. pvalue<0. value0 value<0 (p-value<0. value=0 pvalue=0 (p-value=0 pvalue<0 value< (p-value<0 value= pvalue= (p-value= pvalue< (p-value< (p-value

Abstract This work aims to evaluate, at different stages, the productive performance, carcass quality, and intestinal biometry of European quails (Coturnix coturnix Coturnix), consuming diets with increasing levels of seaweed bran (Sargassum sp). A total of 240 European quail chicks (Coturnix coturnix Coturnix) were distributed in a completely randomized design, with four levels of bran inclusion (0.0, 2.5, 5.0, and 7.5%), 6 replications with 10 birds in each experimental plot. In the period from 1 to 21 days, the feed intake of the control group was higher, with lower water consumption. In the period from 22 to 42 days, feed and water consumption increased with the inclusion of seaweed, but with a reduction in weight gain. In the total period, water consumption was higher at the level of 2.5 and 7.5%, with lower consumption in the control group, with a small reduction in slaughter and carcass weight with the inclusion of bran. There was no difference (P > 0.05) in carcass quality and intestinal biometry. We recommended the inclusion of up to 7.5% of sargassum meal in the diet of European quails at all stages, without compromising its productive performance, carcass quality, and intestinal biometry. evaluate stages performance Coturnix Coturnix, , Sargassum sp. sp . sp) 24 design 0.0, 00 0 (0.0 25 2 5 50 5.0 75 7 7.5%) plot days 4 gain 2. P 0.05 005 05 7.5 0.0 (0. 5. 7. 0. (0 (

ABSTRACT Programmatic vulnerability concerns access to and use of health resources, such as programs aimed at health prevention, care, and rehabilitation. For LGBTQIA+ older people, vulnerability issues are even more significant, since that group faces other social issues that reflect on the preparation of professionals to provide care in health services. The aim was to map the occurrence of programmatic vulnerability among LGBTQIA+ older people. This is a scoping review, guided by the JBI recommendations using the mnemonic P (LGBTQIA+ older people), C (vulnerability), and C (healthcare programs). The documents were analyzed qualitatively using the R Interface software, IRaMuTeQ. Two thematic categories were identified: The construction of comprehensive care: the role of health and social institutions in developing actions aimed at the needs of LGBTQIA+ older people; Programmatic vulnerability: gaps in care for older people belonging to sexual minorities. This study identified that situations of vulnerability are more evident in health services, long-term care institutions, and in care provided by health professionals, suffering from stigma and prejudice.

RESUMO A vulnerabilidade programática diz respeito a acesso e utilização dos recursos de saúde, como programas direcionados a prevenção, assistência e reabilitação de saúde. Para a pessoa idosa LGBTQIA+, as questões de vulnerabilidade são ainda mais significativas, uma vez que o referido grupo enfrenta outras questões de cunho social que refletem no preparo dos profissionais ante o atendimento nos serviços de saúde. Objetivou-se mapear a ocorrência da vulnerabilidade programática de pessoas idosas LGBTQIA+. Trata-se de uma revisão de escopo, orientada pelas recomendações JBI mediante o mnemônico P (Idosos LGBTQIA+), C (vulnerabilidade) e C (programas de atenção à saúde). Os documentos foram analisados qualitativamente com suporte do software Interface de R, IRaMuTeQ. Foram identificadas duas categorias temáticas: A construção do cuidado integral: o papel das instituições de saúde e social no desenvolvimento de ações voltadas para as necessidades da pessoa idosa LGBTQIA+; Vulnerabilidade programática: lacunas no cuidado à pessoa idosa pertencente a minorias sexuais. O presente estudou permitiu identificar que as pessoas idosas LGBTQIA+ podem vivenciar situações de vulnerabilidade programática, sobretudo nos serviços de saúde, instituições de longa permanência e nos atendimentos ofertados pelos profissionais de saúde, sob a ótica do estigma e preconceito.

RESUMO A vulnerabilidade programática diz respeito a acesso e utilização dos recursos de saúde, como programas direcionados a prevenção, assistência e reabilitação de saúde. Para a pessoa idosa LGBTQIA+, as questões de vulnerabilidade são ainda mais significativas, uma vez que o referido grupo enfrenta outras questões de cunho social que refletem no preparo dos profissionais ante o atendimento nos serviços de saúde. Objetivou-se mapear a ocorrência da vulnerabilidade programática de pessoas idosas LGBTQIA+. Trata-se de uma revisão de escopo, orientada pelas recomendações JBI mediante o mnemônico P (Idosos LGBTQIA+), C (vulnerabilidade) e C (programas de atenção à saúde). Os documentos foram analisados qualitativamente com suporte do software Interface de R, IRaMuTeQ. Foram identificadas duas categorias temáticas: A construção do cuidado integral: o papel das instituições de saúde e social no desenvolvimento de ações voltadas para as necessidades da pessoa idosa LGBTQIA+; Vulnerabilidade programática: lacunas no cuidado à pessoa idosa pertencente a minorias sexuais. O presente estudou permitiu identificar que as pessoas idosas LGBTQIA+ podem vivenciar situações de vulnerabilidade programática, sobretudo nos serviços de saúde, instituições de longa permanência e nos atendimentos ofertados pelos profissionais de saúde, sob a ótica do estigma e preconceito. prevenção LGBTQIA significativas Objetivouse Objetivou se Tratase Trata escopo Idosos , LGBTQIA+) (vulnerabilidade . saúde) R IRaMuTeQ temáticas integral sexuais preconceito

ABSTRACT Programmatic vulnerability concerns access to and use of health resources, such as programs aimed at health prevention, care, and rehabilitation. For LGBTQIA+ older people, vulnerability issues are even more significant, since that group faces other social issues that reflect on the preparation of professionals to provide care in health services. The aim was to map the occurrence of programmatic vulnerability among LGBTQIA+ older people. This is a scoping review, guided by the JBI recommendations using the mnemonic P (LGBTQIA+ older people), C (vulnerability), and C (healthcare programs). The documents were analyzed qualitatively using the R Interface software, IRaMuTeQ. Two thematic categories were identified: The construction of comprehensive care: the role of health and social institutions in developing actions aimed at the needs of LGBTQIA+ older people; Programmatic vulnerability: gaps in care for older people belonging to sexual minorities. This study identified that situations of vulnerability are more evident in health services, long-term care institutions, and in care provided by health professionals, suffering from stigma and prejudice. resources prevention rehabilitation LGBTQIA significant services review (LGBTQIA , people) vulnerability, (vulnerability) healthcare programs. . programs) software IRaMuTeQ minorities longterm long term prejudice (vulnerability

Resumo Introdução: Sensibilização HLA é uma barreira ao transplante em pacientes sensibilizados. Há poucos dados publicados sobre dessensibilização utilizando somente imunoglobulina intravenosa humana polivalente (IgIV). Métodos: Revisamos retrospectivamente prontuários de 45 pacientes com prova cruzada positiva por citotoxicidade dependente do complemento (CDCXM) ou citometria de fluxo (FCXM) contra doadores vivos, de Janeiro/2003-Dezembro/2014. Destes, excluímos 12. 33 pacientes receberam infusões mensais de IgIV (2 g/kg) apenas até apresentarem FCXM células T e B negativa. Resultados: Durante dessensibilização, 22 pacientes (66,7%) realizaram transplante renal com doador vivo, 7 (21,2%) receberam enxerto de doador falecido, 4 (12,1%) não realizaram transplante. A mediana do painel de reatividade de anticorpos classes I e II para estes pacientes foi 80,5% (intervalo 61%-95%) e 83,0% (intervalo 42%-94%), respectivamente. 18 pacientes (81,8%) apresentaram CDCXM célula T e/ou B positiva; 4 (18,2%) apresentaram FCXM célula T e/ou B positiva. Pacientes realizaram transplante após mediana de 6 (intervalo 3-16) infusões. A mediana da somatória da intensidade média de fluorescência do anticorpo específico contra o doador foi 5057 (intervalo 2246-11.691) antes e 1389 (intervalo 934-2492) após dessensibilização (p = 0,0001). O tempo médio de acompanhamento do paciente pós transplante foi 60,5 (DP, 36,8) meses. Nove pacientes (45,0%) não apresentaram rejeição e 6 (27,3%) apresentaram rejeição mediada por anticorpos. Sobrevida do enxerto censurada para óbito em 1, 3, 5 anos após transplante foi 86,4; 86,4; 79,2%, respectivamente, e sobrevida do paciente foi 95,5; 95,5; 83,7%, respectivamente. Conclusões: Dessensibilização utilizando apenas IgIV é uma estratégia eficaz, permitindo transplante bem-sucedido em 87,9% destes pacientes altamente sensibilizados. Introdução sensibilizados IgIV. . (IgIV) Métodos (CDCXM (FCXM vivos Janeiro/2003Dezembro/2014. Janeiro2003Dezembro2014 JaneiroDezembro Janeiro/2003 Dezembro/2014. Janeiro 2003 Dezembro 2014 Janeiro/2003-Dezembro/2014 Destes 12 3 2 ( g/kg gkg g kg negativa Resultados 66,7% 667 66 (66,7% vivo 21,2% 212 21 (21,2% falecido 12,1% 121 1 (12,1% 805 80 80,5 intervalo 61%95% 6195 61% 95% 61 95 61%-95% 830 83 0 83,0 42%94%, 4294 42% 94% , 42 94 42%-94%) respectivamente 81,8% 818 81 8 (81,8% eou 18,2% 182 (18,2% 316 16 3-16 505 224611.691 224611691 2246 11.691 11 691 2246-11.691 138 9342492 934 2492 934-2492 p 0,0001. 00001 0,0001 0001 0,0001) 605 60 60, DP, DP (DP 36,8 368 36 meses 45,0% 450 (45,0% 27,3% 273 27 (27,3% 86,4 864 86 792 79 79,2% 95,5 955 837 83,7% Conclusões eficaz bemsucedido bem sucedido 879 87 9 87,9 (IgIV 2003Dezembro Janeiro/2003Dezembro/2014 Janeiro2003Dezembro201 Janeiro2003 Janeiro/200 Dezembro2014 Dezembro/2014 200 201 Janeiro/2003-Dezembro/201 66,7 (66,7 21,2 (21,2 12,1 (12,1 80, 61%95 619 61%-95 83, 42%94% 429 42%-94% 81,8 (81,8 18,2 (18,2 31 3-1 50 224611 224611.69 22461169 224 11691 11.69 69 2246-11.69 13 934249 93 249 934-249 0000 0,000 000 36, 45,0 (45,0 27,3 (27,3 86, 79,2 95, 83,7 87, Janeiro/2003Dezembro/201 Janeiro2003Dezembro20 Janeiro200 Janeiro/20 Dezembro201 Dezembro/201 20 Janeiro/2003-Dezembro/20 66, (66, 21, (21, 12, (12, 61%9 61%-9 42%94 42%-94 81, (81, 18, (18, 3- 22461 224611.6 2246116 1169 11.6 2246-11.6 93424 24 934-24 0,00 00 45, (45, 27, (27, 79, Janeiro/2003Dezembro/20 Janeiro2003Dezembro2 Janeiro20 Janeiro/2 Dezembro20 Dezembro/20 Janeiro/2003-Dezembro/2 (66 (21 (12 61%- 42%9 42%-9 (81 (18 224611. 116 11. 2246-11. 9342 934-2 0,0 (45 (27 Janeiro/2003Dezembro/2 Janeiro2003Dezembro Janeiro2 Janeiro/ Dezembro2 Dezembro/2 Janeiro/2003-Dezembro/ (6 (1 42%- (8 2246-11 934- 0, (4 Janeiro/2003Dezembro/ Dezembro/ Janeiro/2003-Dezembro 2246-1 Janeiro/2003Dezembro 2246-

Abstract Introduction: Sensitization to human leukocyte antigen is a barrier to. Few data have been published on desensitization using polyvalent human intravenous immunoglobulin (IVIG) alone. Methods: We retrospectively reviewed the of 45 patients with a positive complement-dependent cytotoxicity crossmatch (CDCXM) or flow cytometry crossmatch (FCXM) against living donors from January 2003 to December 2014. Of these, 12 were excluded. Patients received monthly IVIG infusions (2 g/kg) only until they had a negative T-cell and B-cell FCXM. Results: During the 33 patients, 22 (66.7%) underwent living donor kidney transplantation, 7 (21.2%) received a deceased donor graft, and 4 (12.1%) did not undergo transplantation. The median class I and II panel reactive antibodies for these patients were 80.5% (range 61%-95%) and 83.0% (range 42%-94%), respectively. Patients (81.8%) had a positive T-cell and/or B-cell CDCXM and 4 (18.2%) had a positive T-cell and/or B-cell FCXM. Patients underwent transplantation after a median of 6 (range 3-16). The median donor-specific antibody mean fluorescence intensity sum was 5057 (range 2246-11,691) before and 1389 (range 934-2492) after desensitization (p = 0.0001). Mean patient follow-up time after transplantation was 60.5 (SD, 36.8) months. Nine patients (45.0%). Death-censored graft survival at 1, 3, and 5 years after transplant was 86.4, 86.4, and 79.2%, respectively and patient survival was 95.5, 95.5, and 83.7%, respectively. Conclusions: Desensitization using IVIG alone is an effective strategy, allowing successful transplantation in 87.9% of these highly sensitized patients. Introduction (IVIG Methods complementdependent complement dependent (CDCXM FCXM (FCXM 200 2014 1 excluded 2 ( g/kg gkg g kg Tcell T cell Bcell B Results 3 66.7% 667 66 (66.7% 21.2% 212 21 (21.2% 12.1% 121 (12.1% 805 80 80.5 range 61%95% 6195 61% 95% 61 95 61%-95% 830 83 0 83.0 42%94%, 4294 42% 94% , 42 94 42%-94%) 81.8% 818 81 8 (81.8% andor 18.2% 182 18 (18.2% 316. 316 16 . 3-16) donorspecific specific 505 224611,691 224611691 2246 11,691 11 691 2246-11,691 138 9342492 934 2492 934-2492 p 0.0001. 00001 0.0001 0001 0.0001) followup follow up 605 60 60. SD, SD (SD 36.8 368 36 months 45.0%. 450 45.0% (45.0%) Deathcensored Death censored 864 86 86.4 792 79 79.2% 955 95.5 837 83.7% Conclusions strategy 879 87 9 87.9 20 201 66.7 (66.7 21.2 (21.2 12.1 (12.1 80. 61%95 619 61%-95 83. 42%94% 429 42%-94% 81.8 (81.8 18.2 (18.2 31 3-16 50 224611 224611,69 22461169 224 11691 11,69 69 2246-11,69 13 934249 93 249 934-249 0000 0.000 000 36. 45.0 (45.0% 86. 79.2 95. 83.7 87. 66. (66. 21. (21. 12. (12. 61%9 61%-9 42%94 42%-94 81. (81. 18. (18. 3-1 22461 224611,6 2246116 1169 11,6 2246-11,6 93424 24 934-24 0.00 00 45. (45.0 79. (66 (21 (12 61%- 42%9 42%-9 (81 (18 3- 224611, 116 11, 2246-11, 9342 934-2 0.0 (45. (6 (1 42%- (8 2246-11 934- 0. (45 2246-1 (4 2246-

Resumo Objetivo Avaliar a associação entre dois índices colposcópicos, o escore Swede e a Nomenclatura International Federation of Cervical Pathology and Colposcopy (IFCPC, na sigla em inglês) 2011, assim como determinar a eficácia do escore Swede com os pontos de corte 7 e 8. Métodos Trata-se de um estudo transversal, com 34 mulheres incluídas, que realizaram colposcopia com biópsia dirigida devido a uma citologia anormal. Os achados colposcópicos foram categorizados pelo escore Swede e pela Nomenclatura IFCPC 2011 e comparados um com o outro. Foram avaliados o coeficiente Kappa e o teste de McNemar e foram calculados a acurácia, a sensibilidade, a especificidade e valores preditivos negativos e positivos (VPN e VPP, respectivamente) de cada índice, assim como a eficácia com os pontos de corte 7 e 8 do escore Swede para determinar as lesões de neoplasia intraepitelial cervical (NIC) 2 + . Resultados A concordância entre os 2 índices foi de 79,41% e o coeficiente Kappa e o valor-p do teste de McNemar foram 0.55 e 0.37, respectivamente. Pela Nomenclatura IFCPC 2011, obtivemos como sensibilidade, especificidade, acurácia, VPP e VPN, respectivamente: 85,71, 55,00, 67,64, 57,14 e 84,61%. Pelo escore Swede obtivemos como sensibilidade, especificidade, acurácia, VPP e VPN, respectivamente: 100, 63,15, 79,41, 68,18 e 100%. O uso do escore Swede para detecção das lesões NIC 2+ obteve como especificidade 94,73% com o valor de corte de 7, enquanto o valor de corte 8 obteve 100%. A sensibilidade para ambos os cortes foi de 60%. O VPP e o VPN com os cortes 7 e 8 foram, respectivamente: 90,00 e 75,00 e 100,00 e 76,00%. Conclusão Ambos os índices colposcópicos tiveram boa reprodutibilidade; no entanto, o escore Swede mostrou melhor acurácia, sensibilidade e especificidade em identificar as lesões NIC 2+ e o melhor ponto de corte para identificar as lesões NIC2+ foi com o valor 8. IFCPC, (IFCPC inglês Tratase Trata se transversal 3 incluídas anormal 201 outro acurácia respectivamente índice (NIC 7941 79 41 79,41 valorp p 055 0 55 0.5 037 37 0.37 8571 85 71 85,71 5500 00 55,00 6764 67 64 67,64 5714 57 14 57,1 8461 84 61 84,61% 100 6315 63 15 63,15 6818 68 18 68,1 100% 9473 94 73 94,73 60 60% 9000 90 90,0 7500 75 75,0 10000 100,0 7600 76 76,00% reprodutibilidade entanto NIC2 20 794 4 79,4 05 5 0. 03 0.3 857 85,7 550 55,0 676 6 67,6 571 1 57, 846 84,61 10 631 63,1 681 68, 947 9 94,7 900 90, 750 75, 1000 760 76,00 79, 85, 55, 67, 84,6 63, 94, 76,0 84, 76,

Abstract Objective To assess the association between two colposcopic indices, the Swede score and the 2011 International Federation of Cervical Pathology and Colposcopy (IFCPC) Nomenclature as well as to determine the efficacy of the Swede score with cutoffs of 7 and 8. Methods In the present cross-sectional pilot study, 34 women who had at least 1 colposcopy-directed biopsy due to abnormal cytology were enrolled. The colposcopic findings were scored by both the Swede score and the 2011 IFCPC Nomenclature and were compared with each other. The Kappa coefficient and the McNemar test were used. Accuracy, sensitivity, specificity, and positive and negative predictive values (NPV and PPV, respectively) were calculated, as well as the effectiveness with cutoffs of 7 and 8 in identifying cervical intraepithelial neoplasm (CIN) 2+ when using the Swede score. Results The correlation between the 2 colposcopic indices was 79.41%. The Kappa coefficient and the McNemar p-value were 0.55 and 0.37, respectively. The IFCPC Nomenclature had sensitivity, specificity, accuracy, PPV, and NPV of 85.71, 55.00, 67.64, 57.14, and 84.61%, respectively. The Swede score had sensitivity, specificity, accuracy, PPV, and NPV of 100, 63.15, 79.41, 68.18, and 100%, respectively. A Swede score cutoff of 7 for CIN 2+ detection had a specificity of 94.73%, while with a cutoff of 8 it increased to 100%. The sensitivity for both values was 60%. The PPV and NPV for cutoffs of 7 and 8 were 90 and 75 and 100 and 76%, respectively. Conclusion Although both colposcopic indices have good reproducibility, the Swede score showed greater accuracy, sensitivity, and specificity in identifying CIN 2 + , especially when using a cutoff of 8. 201 (IFCPC crosssectional cross sectional study 3 colposcopydirected colposcopy directed enrolled other used Accuracy respectively calculated (CIN 7941 79 41 79.41% pvalue p value 055 0 55 0.5 037 37 0.37 accuracy 8571 85 71 85.71 5500 00 55.00 6764 67 64 67.64 5714 57 14 57.14 8461 84 61 84.61% 6315 63 15 63.15 79.41 6818 68 18 68.18 100% 9473 94 73 94.73% 60 60% 9 10 76 76% reproducibility 20 794 4 05 5 0. 03 0.3 857 85.7 550 55.0 676 6 67.6 571 57.1 846 84.61 631 63.1 79.4 681 68.1 947 94.73 85. 55. 67. 57. 84.6 63. 79. 68. 94.7 84. 94.

RESUMO Objetivo: A silicose é uma pneumoconiose caracterizada por fibrose do parênquima pulmonar causada por inalação de partículas de sílica. Fatores genéticos podem desempenhar um papel na gravidade da silicose. Nosso objetivo foi avaliar a influência de polimorfismos dos genes ACE, FAS, FASLG, NOS2, IL1RN, FAM13A, TGFB1 e TNF na gravidade da silicose. Métodos: Nove polimorfismos foram genotipados por meio de PCR em uma amostra composta por 143 pacientes com silicose no estado do Rio de Janeiro, Brasil. Resultados: A silicose foi classificada em simples em 57 (40%) dos pacientes e em complicada, em 86 (60%). O genótipo TT do polimorfismo rs1800469 do gene TGFB1 teve efeito protetor contra a silicose complicada (OR = 0,35; IC95%: 0,14-0,92; p = 0,028) em comparação com os outros dois genótipos (CC+CT). O alelo T polimórfico do polimorfismo rs763110 do gene FASLG (OR = 0,56; IC95%: 0,31-0,99; p = 0,047) e um modelo dominante do alelo T (TT+CT: OR = 0,37; IC95%: 0,15-0,96; p = 0,037) também tiveram efeito protetor. Quando se compararam os pacientes que tinham silicose simples com um tempo maior de exposição à sílica (> 44.229 horas) àqueles que tinham silicose complicada com um tempo menor de exposição à sílica, o alelo T do polimorfismo rs763110 do gene FASLG (OR = 0,20; IC95%: 0,08-0,48; p < 0,0001) e modelos dominantes e recessivos (OR = 0,06; IC95%: 0,00-0,49; p = 0,01 e OR = 0,22; IC95%: 0,06-0,77; p = 0,014, respectivamente) tiveram efeito protetor contra a gravidade da silicose. Conclusões: Polimorfismos rs1800469 do gene TGFB1 e polimorfismos rs763110 do gene FASLG parecem estar envolvidos na gravidade da silicose. Como há poucos estudos que tenham estabelecido relações entre polimorfismos genéticos e a gravidade da silicose, esses resultados devem ser replicados em outras populações.

ABSTRACT Objective: Silicosis is a pneumoconiosis characterized by fibrosis of the lung parenchyma caused by inhalation of silica particles. Genetic factors might play a role in the severity silicosis. We sought to evaluate the influence of polymorphisms in the ACE, FAS, FASLG, NOS2, IL1RN, FAM13A, TGFB1, and TNF genes on the severity of silicosis. Methods: Nine polymorphisms were genotyped by PCR in a sample of 143 patients with silicosis in the state of Rio de Janeiro, Brazil. Results: Fifty-seven patients (40%) were classified as having simple silicosis and 86 (60%) were classified as having complicated silicosis. The TT genotype of rs1800469 in the TGFB1 gene showed a protective effect for complicated silicosis (OR = 0.35; 95% CI, 0.14-0.92; p = 0.028) when compared with the other two genotypes (CC+CT). The polymorphic T allele of rs763110 in the FASLG gene (OR = 0.56; 95% CI, 0.31-0.99; p = 0.047), as well as a dominant model for the T allele (TT+CT: OR = 0.37; 95% CI, 0.15-0.96; p = 0.037), also showed a protective effect. When patients with simple silicosis despite having been exposed to silica for a longer time (> 44,229 hours) were compared with patients with complicated silicosis despite having been exposed to silica for a shorter time, the T allele of rs763110 in the FASLG gene (OR = 0.20; 95% CI, 0.08-0.48; p < 0.0001), as well as dominant and recessive models (OR = 0.06; 95% CI, 0.00-0.49; p = 0.01 and OR = 0.22; 95% CI, 0.06-0.77; p = 0.014, respectively), showed a protective effect against the severity of silicosis. Conclusions: It appears that rs1800469 polymorphisms in the TGFB1 gene and rs763110 polymorphisms in the FASLG gene are involved in the severity of silicosis. Given the lack of studies relating genetic polymorphisms to the severity of silicosis, these results should be replicated in other populations.