ABSTRACT Objectives: Body composition changes are associated with adverse effects such as increased insulin resistance (IR) in individuals with diabetes mellitus. This study aims to evaluate the association between different body adiposity markers and IR in adults with type 1 diabetes (T1D). Subjects and methods: The cross-sectional study included outpatient adults with T1D from a university public hospital in southern Brazil. The body adiposity markers studied were waist circumference (WC), waist-height ratio (WHtR), body mass index (BMI), conicity index (CI), lipid accumulation product (LAP) and body adiposity index (BAI). IR was calculated using an Estimated Glucose Disposal Rate (EGDR) equation (analyzed in tertiles), considering an inverse relation between EGDR and IR. Poisson regression models were used to estimate the odds ratio (OR) and 95% CIs of association of adiposity markers with IR. Results: A total of 128 patients were enrolled (51% women), with a median EGDR of 7.2 (4.4-8.7) mg.kg−1.min−1. EGDR was negatively correlated with WC (r = −0.36, p < 0.01), WHtR (r = −0.39, p < 0.01), CI (r = −0.44, p < 0.01), LAP (r = −0.41, p < 0.01) and BMI (r = −0.24, p < 0.01). After regression analyses, WC (OR = 2.07; CIs: 1.12-3.337; p = 0.003), WHtR (OR = 2.77; CIs: 1.59-4.79; p < 0.001), CI (OR = 2.59; CIs: 1.43-4.66; p = 0.002), LAP (OR = 2.27; CIs: 1.25-4.11; p = 0.007) and BMI (OR = 1.78; CIs: 1.09-2.91; p = 0.019) remained associated with IR. Conclusions: The authors suggest using the studied adiposity markers as a routine since they were shown to be suitable parameters in association with IR. Objectives (IR mellitus T1D. TD . T D (T1D) methods crosssectional cross sectional Brazil WC, , (WC) waistheight height WHtR, (WHtR) BMI, (BMI) CI, (CI) (LAP BAI. BAI (BAI) (EGDR analyzed tertiles, tertiles tertiles) OR 95 Results 12 51% 51 (51 women, women women) 72 7 2 7. 4.48.7 4487 4.4 8.7 4 8 (4.4-8.7 mgkg1min1 mgkgmin mg kg min mg.kg−1.min−1 r 036 0 36 −0.36 0.01, 001 0.01 01 039 39 −0.39 044 44 −0.44 041 41 −0.41 024 24 −0.24 0.01. analyses 2.07 207 07 1.123.337 1123337 1.12 3.337 3 337 1.12-3.337 0.003, 0003 0.003 003 0.003) 2.77 277 77 1.594.79 159479 1.59 4.79 59 79 1.59-4.79 0.001, 0001 0.001 0.001) 2.59 259 1.434.66 143466 1.43 4.66 43 66 1.43-4.66 0.002, 0002 0.002 002 0.002) 2.27 227 27 1.254.11 125411 1.25 4.11 25 11 1.25-4.11 0.007 0007 007 1.78 178 78 1.092.91 109291 1.09 2.91 09 91 1.09-2.91 0.019 0019 019 Conclusions (T1D (WC (WHtR (BMI (CI (BAI 9 5 (5 48 4.48. 448 4. 87 8. (4.4-8. mgkg mgkg1min mg.kg−1.min− 03 −0.3 00 0.0 04 −0.4 02 −0.2 2.0 20 123 1.123.33 112333 112 1.1 3337 3.33 33 1.12-3.33 000 0.00 2.7 594 1.594.7 15947 159 1.5 479 4.7 1.59-4.7 2.5 434 1.434.6 14346 143 1.4 466 4.6 6 1.43-4.6 2.2 22 254 1.254.1 12541 125 1.2 411 4.1 1.25-4.1 1.7 17 092 1.092.9 10929 109 1.0 291 2.9 1.09-2.9 ( 4.48 (4.4-8 mg.kg−1.min −0. 0. 2. 1.123.3 11233 1. 333 3.3 1.12-3.3 1.594. 1594 15 47 1.59-4. 1.434. 1434 14 46 1.43-4. 1.254. 1254 1.25-4. 1.092. 1092 10 29 1.09-2. (4.4- −0 1.123. 1123 3. 1.12-3. 1.594 1.59-4 1.434 1.43-4 1.254 1.25-4 1.092 1.09-2 (4.4 − 1.123 1.12-3 1.59- 1.43- 1.25- 1.09- (4. 1.12- (4

RESUMO Objetivo Investigar a prevalência e os fatores associados à suspeição de transtornos mentais comuns (TMCs) em idosos de um município de pequeno porte do Nordeste brasileiro. Métodos Estudo epidemiológico populacional, com delineamento transversal, realizado com idosos da área urbana de Aiquara-BA. As informações sociodemográficas, de hábitos de vida e de condições de saúde foram coletadas, em entrevistas, a partir de um instrumento próprio. O nível de atividade física foi averiguado por meio do International Physical Activity Questionnaire. Foram considerados insuficientemente ativos os entrevistados que despendiam tempo < 150 mim/sem em atividade física. A identificação da suspeição de TMCs foi realizada pelo Self-Reporting Questionnaire, com ponto de corte de sete ou mais respostas positivas. Para as análises inferenciais, utilizou-se o teste qui-quadrado de Pearson, regressão logística multivariada e seus respectivos intervalos de confiança (ICs) de 95,0% (p ≤ 0,05). Resultados Participaram do estudo 232 idosos (58,6% mulheres), com média de idade de 71,6 ± 7,5 anos e prevalência de suspeição de TMCs de 32,6%. No modelo final de regressão, foi observado que estiveram associadas à suspeição de TMCs: as mulheres (RP: 2,49; IC95%: 1,27-4,88); os idosos com autopercepção negativa de saúde (RP: 2,73; IC95%: 1,46-5,10); os idosos que referiram ter distúrbios do sono (RP: 3,12; IC95%: 1,56-6,21); e os insuficientemente ativos (RP: 2,30; IC95%: 1,20-4,41). Conclusão Em Aiquara-BA, identificou-se elevada prevalência de suspeição de TMCs, principalmente em mulheres, nos avaliados com autopercepção de saúde negativa, entre os que referiram ter distúrbios do sono e nos participantes insuficientemente ativos. (TMCs brasileiro populacional transversal AiquaraBA. AiquaraBA Aiquara BA. BA Aiquara-BA sociodemográficas coletadas entrevistas próprio Questionnaire 15 mimsem mim sem SelfReporting Self Reporting positivas inferenciais utilizouse utilizou se quiquadrado qui quadrado Pearson ICs (ICs 950 95 0 95,0 p 0,05. 005 0,05 . 05 0,05) 23 58,6% 586 58 6 (58,6 , mulheres) 716 71 71, 75 7 5 7, 326 32 32,6% RP (RP 2,49 249 2 49 IC95% IC95 IC 1,274,88 127488 1,27 4,88 1 27 4 88 1,27-4,88) 2,73 273 73 1,465,10 146510 1,46 5,10 46 10 1,46-5,10) 3,12 312 3 12 1,566,21 156621 1,56 6,21 56 21 1,56-6,21) 2,30 230 30 1,204,41. 120441 1,20 4,41 20 41 1,20-4,41) AiquaraBA, BA, identificouse identificou 9 95, 00 0,0 58,6 (58, 32,6 2,4 24 IC9 274 1,274,8 12748 127 1,2 488 4,8 8 1,27-4,88 2,7 465 1,465,1 14651 146 1,4 510 5,1 1,46-5,10 3,1 31 566 1,566,2 15662 156 1,5 621 6,2 1,56-6,21 2,3 204 1,204,41 12044 120 441 4,4 1,20-4,41 0, 58, (58 32, 2, 1,274, 1274 1, 48 4, 1,27-4,8 1,465, 1465 14 51 5, 1,46-5,1 3, 1,566, 1566 62 6, 1,56-6,2 1,204,4 1204 44 1,20-4,4 (5 1,274 1,27-4, 1,465 1,46-5, 1,566 1,56-6, 1,204, 1,20-4, ( 1,27-4 1,46-5 1,56-6 1,204 1,20-4 1,27- 1,46- 1,56- 1,20-

ABSTRACT Objective To investigate the prevalence and factors associated with suspected common mental disorders (CMD) in older adults in a small municipality in Northeastern Brazil. Methods Population epidemiological cross-sectional study carried out with older adults from the urban area of Aiquara, BA. Sociodemographic information, lifestyle and health conditions were collected in interviews, using a specific instrument. The level of physical activity was assessed using the International Physical Activity Questionnaire. Respondents who dismissed time < 150 min/wk in physical activity were considered insufficiently active. The identification of suspected CMD was performed using the Self-Reporting Questionnaire, with a cut-off point of seven or more positive responses. For inferential analyses, Pearson’s chi-square test and multivariate logistic regression were used, and their respective 95% confidence intervals (CIs) (p ≤ 0.05). Results A total of 232 older adults (58.6% women), with a mean age of 71.6 ± 7.5 years participated in the study and 32.6% exhibited suspected CMD. In the final regression model, it was observed that women were associated with suspected CMD (PR: 2.49; 95% CI: 1.27-4.88); older adults with self-perceived poor health (PR: 2.73; 95%CI: 1.46-5.10); the older adults who reported experiencing sleep disorders (PR: 3.12; 95%CI: 1.56-6.21) and those who were insufficiently active (PR: 2.30; 95%CI: 1.20-4.41). Conclusion In Aiquara, BA, a high prevalence of suspected common mental disorders was identified, especially in women, in patients evaluated with negative self-perceived health, among those who reported having sleep disorders and in insufficiently active participants. (CMD Brazil crosssectional cross sectional Aiquara BA information interviews instrument Questionnaire 15 minwk min wk SelfReporting Self Reporting cutoff cut off responses analyses Pearsons Pearson s chisquare chi square used 95 CIs (CIs p 0.05. 005 0.05 . 0 05 0.05) 23 58.6% 586 58 6 (58.6 , women) 716 71 71. 75 7 5 7. 326 32 32.6 model PR (PR 2.49 249 2 49 CI 1.274.88 127488 1.27 4.88 1 27 4 88 1.27-4.88) selfperceived self perceived 2.73 273 73 95%CI 95CI 1.465.10 146510 1.46 5.10 46 10 1.46-5.10) 3.12 312 3 12 1.566.21 156621 1.56 6.21 56 21 1.56-6.21 2.30 230 30 1.204.41. 120441 1.20 4.41 20 41 1.20-4.41) identified participants 9 00 0.0 58.6 (58. 32. 2.4 24 274 1.274.8 12748 127 1.2 488 4.8 8 1.27-4.88 2.7 465 1.465.1 14651 146 1.4 510 5.1 1.46-5.10 3.1 31 566 1.566.2 15662 156 1.5 621 6.2 1.56-6.2 2.3 204 1.204.41 12044 120 441 4.4 1.20-4.41 0. 58. (58 2. 1.274. 1274 1. 48 4. 1.27-4.8 1.465. 1465 14 51 5. 1.46-5.1 3. 1.566. 1566 62 6. 1.56-6. 1.204.4 1204 44 1.20-4.4 (5 1.274 1.27-4. 1.465 1.46-5. 1.566 1.56-6 1.204. 1.20-4. ( 1.27-4 1.46-5 1.56- 1.204 1.20-4 1.27- 1.46- 1.20-

Metabolomics can provide a readout of the biochemical and physiological state of a biological system. Gas chromatography coupled to mass spectrometry (GC-MS) has been widely applied for metabolomic analysis due to its numerous advantages, such as good sensitivity, high resolution, reproducibility, extensive database, lower acquisition cost and greater coverage. In addition, combined with efficient methods of sampling and sample preparation, the metabolomic analysis of damaged skin based on GC-MS can provide an important step toward elucidating several skin diseases. Based on this, this review presents a comprehensive overview of sampling, sample preparation, data processing and GC-MS analysis of metabolomic studies of damaged skin. Also, part of the biological interpretation of metabolites such as cis- and trans-urocanic acid (UCA) altered in photoexposed skin and lauric acid (C12:0) and palmitic acid (C16:0) in melanoma is discussed. Finally, to improve decision-making, a part of the integration of skin metabolomics with other omics sciences for the advancement of diagnosis is presented. system GCMS GC MS (GC-MS advantages sensitivity resolution reproducibility database coverage addition preparation diseases Also cis transurocanic trans urocanic UCA (UCA C120 C C12 0 (C12:0 C160 C16 (C16:0 discussed Finally decisionmaking, decisionmaking decision making, making decision-making presented C1 (C12: (C16: (C12 (C16 (C1 (C

Abstract Fetal programming suggests that maternal stimulation and nutrition during the period of fetal development can program the progeny. Conjugated linoleic acid (CLA), an isomer of linoleic acid, has been characterized in several aspects, but few studies have been performed on its involvement in reproduction and fetal programming. The aim of this study was to evaluate the F1, F2 and F3 progeny of female mice supplemented with CLA during the pregestational and gestational periods with respect to biometric and reproductive parameters, as well as ovarian morphophysiology. The F1 progeny of mothers supplemented with CLA exhibited stable weight gain, while the F2 progeny showed no effects (P=0.0187 and P=0.0245, respectively). A reduction in Lee's Index was observed in both generations at the second post-weaning evaluation week in the animals treated with CLA (P=0.0100 and P=0.0078, respectively). The F2 generation showed an increase in the anogenital index in both sexes of the animals treated with CLA (P= 0.0114 and P<0.0001, female and male respectively). CLA administration to mothers did not affect any of the following in their progeny: ovarian follicle mobilization (P>0.05), follicle number (P>0.05) and the integrated density of the lipid content of oocytes included in antral follicles (P>0.05). This study evaluated the use of CLA in mothers and found that it did not affect the progeny regarding murine reproductive performance, suggesting that this supplement can be used safely. CLA, , (CLA) aspects F parameters morphophysiology gain P=0.0187 P00187 P 0 0187 (P=0.018 P00245 0245 P=0.0245 respectively. respectively . respectively) Lees Lee s postweaning post weaning P=0.0100 P00100 0100 (P=0.010 P00078 0078 P=0.0078 P= (P 00114 0114 0.011 P00001 0001 P<0.0001 P>0.05, P005 P>0.05 05 (P>0.05 P>0.05. performance safely (CLA P=0.018 P0018 018 (P=0.01 P0024 024 P=0.024 P=0.010 P0010 010 P0007 007 P=0.007 0011 011 0.01 P0000 000 P<0.000 P00 P>0.0 (P>0.0 P=0.01 P001 01 (P=0.0 P002 02 P=0.02 P000 00 P=0.00 001 0.0 P<0.00 P0 P>0. (P>0. P=0.0 (P=0. 0. P<0.0 P>0 (P>0 P=0. (P=0 P<0. P> (P> P=0 P<0 P<

RESUMEN Objetivo: Validar el instrumento de medición que evalúa el uso y la adhesión de los equipos de protección individual entre los residentes de salud. Método: Estudio metodológico desarrollado en un entorno virtual entre agosto de 2020 y marzo de 2021 con residentes de atención primaria y hospitalaria de las cinco regiones de Brasil. Los participantes respondieron a la versión adaptada del “E.P.I.-APS” para residentes. Se utilizó un análisis factorial confirmatorio para validar el instrumento. Resultados: Participaron 227 residentes, en su mayoría mujeres cis (82,8%), que trabajaban en el sureste (58,1%) y en cuidados hospitalarios (47,6%). Se confirmó la estructura en ocho dominios (gorro; guantes; comportamiento de seguridad; mascarilla N95; higiene de las manos; delantal/abrigo; mascarilla quirúrgica; gafas/protector facial). Sólo se mantuvieron dos ítems con una carga factorial inferior a 0,5. Conclusión: La herramienta es válida para medir el uso y la adhesión de los equipos de protección individual entre los residentes, lo que ayuda a orientar la formación y la seguridad laboral. Objetivo salud Método 202 Brasil E.P.I.APS EPIAPS E.P.I. APS E P I “E.P.I.-APS Resultados 22 82,8%, 828 82,8% , 82 8 (82,8%) 58,1% 581 58 1 (58,1% 47,6%. 476 47,6% . 47 6 (47,6%) gorro (gorro guantes N95 N manos delantal/abrigo delantalabrigo delantal abrigo quirúrgica gafasprotector gafas protector facial. facial facial) 05 0 5 0,5 Conclusión laboral 20 EPI E.P.I 2 82,8 (82,8% 58,1 (58,1 47,6 4 (47,6% N9 0, 82, (82,8 58, (58, 47, (47,6 (82, (58 (47, (82 (5 (47 (8 ( (4

RESUMO Objetivo: Validar o instrumento de medida que avalia o uso e a adesão de equipamentos de proteção individual entre os residentes de saúde. Método: Estudo metodológico desenvolvido em ambiente virtual entre agosto de 2020 e março de 2021 com residentes da atenção primária e hospitalar das cinco regiões do Brasil. Os participantes responderam a versão adaptada para residentes do “E.P.I.-APS”. Utilizou-se a análise fatorial confirmatória para validação do instrumento. Resultados: Participaram 227 residentes, sendo maioria mulher cis (82,8%), atuavam na região Sudeste (58,1%) e em atenção hospitalar (47,6%). A estrutura em oito domínios (gorro/touca; luvas; comportamento de segurança; máscara N95; higienização das mãos; avental/capote; máscara cirúrgica; óculos de proteção/protetor facial) foi confirmada. Apenas dois itens com carga fatorial inferior a 0,5 foram mantidos. Conclusão: O instrumento é válido para mensurar o uso e adesão aos equipamentos de proteção individual entre residentes, o que contribui para direcionar a formação e a segurança laboral. Objetivo saúde Método 202 Brasil E.P.I.APS. EPIAPS E.P.I. APS . E P I “E.P.I.-APS” Utilizouse Utilizou se Resultados 22 82,8%, 828 82,8% , 82 8 (82,8%) 58,1% 581 58 1 (58,1% 47,6%. 476 47,6% 47 6 (47,6%) gorro/touca gorrotouca gorro touca (gorro/touca luvas N95 N mãos avental/capote aventalcapote avental capote cirúrgica proteçãoprotetor protetor facial confirmada 05 0 5 0, mantidos Conclusão laboral 20 E.P.I.APS EPI E.P.I “E.P.I.-APS 2 82,8 (82,8% 58,1 (58,1 47,6 4 (47,6% N9 82, (82,8 58, (58, 47, (47,6 (82, (58 (47, (82 (5 (47 (8 ( (4

ABSTRACT Objective: To validate the measuring instrument that assesses healthcare residents’ use and adherence to personal protective equipment. Method: Methodological study developed in a virtual environment between August 2020 and March 2021 with primary care and hospital residents from the five regions of Brazil. The participants answered the adapted version of the “P.P.E.-PHC” for residents. Confirmatory factor analysis was used to validate the instrument. Results: 227 residents took part, the majority of whom were cis women (82.8%), worked in the Southeast region (58.1%), and in-hospital care (47.6%). The structure in eight domains (cap, gloves, safety behavior, N95 mask, hand hygiene, apron/coat, surgical mask, goggles/face shield) was confirmed. Only two items with a factor load of less than 0.5 were kept. Conclusion: The tool is valid for measuring residents’ use of and adherence to personal protective equipment, which helps to guide training and occupational safety. Objective equipment Method 202 Brazil P.P.E.PHC PPEPHC P.P.E. PHC P E “P.P.E.-PHC Results 22 part 82.8%, 828 82.8% , 82 8 (82.8%) 58.1%, 581 58.1% 58 1 (58.1%) inhospital 47.6%. 476 47.6% . 47 6 (47.6%) cap, cap (cap gloves behavior N N9 mask hygiene aproncoat apron coat apron/coat gogglesface goggles face shield confirmed 05 0 5 0. kept Conclusion 20 PPE P.P.E 2 82.8 (82.8% 58.1 (58.1% 47.6 4 (47.6% 82. (82.8 58. (58.1 47. (47.6 (82. (58. (47. (82 (58 (47 (8 (5 (4 (

Resumo Fundamento A hipercolesterolemia familiar (HF) é uma doença genética dominante que se caracteriza por níveis sanguíneos elevados de colesterol de lipoproteína de baixa densidade (LDL-C), e está associada à ocorrência de doença cardiovascular precoce. No Brasil, o HipercolBrasil, que é atualmente o maior programa de rastreamento em cascata para HF, já identificou mais de 2.000 indivíduos com variantes genéticas causadoras de HF. A abordagem padrão baseia-se no rastreamento em cascata de casos índices referidos, indivíduos com hipercolesterolemia e suspeita clínica de HF. Objetivos Realizar rastreamento direcionado de 11 pequenos municípios brasileiros com suspeita de alta prevalência de indivíduos com HF. Métodos A seleção dos municípios ocorreu de 3 maneiras: 1) municípios em que houve suspeita de efeito fundador (4 municípios); 2) municípios em uma região com altas taxas de infarto do miocárdio precoce, conforme descrito pelo banco de dados do Sistema Único de Saúde (2 municípios); e 3) municípios geograficamente próximos a outros municípios com alta prevalência de indivíduos com HF (5 municípios). A significância estatística foi considerada como valor p < 0,05. Resultados Foram incluídos 105 casos índices e 409 familiares de primeiro grau. O rendimento dessa abordagem foi de 4,67 familiares por caso índice, o qual é significativamente melhor (p < 0,0001) do que a taxa geral do HipercolBrasil (1,59). Identificamos 36 CIs com variante patogênica ou provavelmente patogênica para HF e 240 familiares de primeiro grau afetados. Conclusão: Nossos dados sugerem que, uma vez detectadas, regiões geográficas específicas justificam uma abordagem direcionada para a identificação de aglomerações de indivíduos com HF.

Abstract Background Familial hypercholesterolemia (FH) is a genetic disease characterized by elevated serum levels of low-density lipoprotein cholesterol (LDL-C), and it is associated with the occurrence of early cardiovascular disease. In Brazil, HipercolBrasil, which is currently the largest FH cascade screening program, has already identified more than 2000 individuals with causal genetic variants for FH. The standard approach is based on cascade screening of referred index cases, individuals with hypercholesterolemia and clinical suspicion of FH. Objectives To perform targeted screening of 11 small Brazilian cities with a suspected high prevalence of people with FH. Methods The selection of cities occurred in 3 ways: 1) cities in which a founder effect was suspected (4 cities); 2) cities in a region with high rates of early myocardial infarction as described by the National Health System database (2 cities); and 3) cities that are geographically close to other cities with a high prevalence of individuals with FH (5 cities). Statistical significance was considered as p value < 0.05. Results One hundred and five index cases and 409 first-degree relatives were enrolled. The yield of such approach of 4.67 relatives per index case was significantly better (p < 0.0001) than the general HipercolBrasil rate (1.59). We identified 36 IC with a pathogenic or likely pathogenic variant for FH and 240 affected first-degree relatives. Conclusion Our data suggest that, once detected, specific geographical regions warrant a target approach for identification of clusters of individuals with FH.

Resumo A partir da análise dos filmes Traídos pelo desejo e Uma mulher fantástica propomos algumas reflexões sobre a constituição das identidades masculinas e cisgêneras. Tais reflexões têm como norteadores alguns elementos das teorias psicanalíticas de Freud, Jean Laplanche e Silvia Bleichmar sobre a construção dessas identidades. Perguntamos o que pode explicar as dificuldades de alguns homens cis em sustentar suas escolhas afetivas quanto aos relacionamentos com mulheres trans. Concluímos que, diante das mulheres trans, homens cis podem experienciar angústias provenientes de seus conflitos psíquicos, em especial daqueles oriundos da constituição de sua identidade de gênero marcada pelo recalcamento da passividade.

Abstract Based on the analysis of the films The Crying Game and A Fantastic Woman, we reflect on the constitution of male and cisgender identities. These reflections are guided by elements of the psychoanalytic theories of Freud, Jean Laplanche and Silvia Bleichmar about the construction of these identities. We question what can explain the difficulties that some cis men have to sustain their affective choices regarding relationships with trans women. We conclude that, in relation to trans women, heterosexual cis men may experience anguish arising from their psychic conflicts, especially those arising from the constitution of their gender identity, marked by the repression of passivity.

Resumo O acesso à saúde e os elementos do processo saúde-doença da população trans são analisados neste artigo a partir das categorias de análise Reconhecimento e Aparecimento Público de Judith Butler. Partimos da análise de entrevistas com nove mulheres transexuais e sete trabalhadoras(es) de um mesmo serviço de referência para o Processo Transexualizador do Sistema Único de Saúde (SUS). Argumentamos que processos de discriminação e desrespeito ao nome social nos serviços de saúde são efeitos de políticas que regulam o reconhecimento e diferenciam pessoas e indivíduos como vidas vivíveis, a serem protegidas, e vidas que poderão ser perdidas sem a proteção dos serviços de saúde. Tais políticas permeiam os processos saúde-doença na medida em que modulam modos de existência baseados em normas hegemônicas de viver e existir nos gêneros e sexualidades, que podem produzir sofrimento e adoecimento. Normas alicerçadas numa referência cisheteropatriarcal e racista, que patologizam experiências e vivências não centradas na branquitude, na heteronormatividade e na cisnormatividade.

Abstract Access to health and the elements of the trans population’s health-disease process are analyzed in this article based on Judith Butler’s Public Appearance and Recognition analysis categories. We started from the analysis of interviews with nine transsexual women and seven workers from the same Brazilian transgender health care from the Unified Health System (SUS). We argue that processes of discrimination and disrespect for the social name in health services are effects of policies that regulate the recognition and differentiate people and individuals as liveable lives, to be protected, and lives that may be lost without the protection of health services. These policies permeate the health-disease processes insofar as they modulate modes of existence based on hegemonic norms of living and existing in genders and sexualities, which can produce suffering and illness. Norms based on the cis heteropatriarchal and racist reference, which pathologize experiences not centered on whiteness as a norm, on heteronormativity, and on cisnormativity.

Resumo O acesso à saúde e os elementos do processo saúde-doença da população trans são analisados neste artigo a partir das categorias de análise Reconhecimento e Aparecimento Público de Judith Butler. Partimos da análise de entrevistas com nove mulheres transexuais e sete trabalhadoras(es) de um mesmo serviço de referência para o Processo Transexualizador do Sistema Único de Saúde (SUS). Argumentamos que processos de discriminação e desrespeito ao nome social nos serviços de saúde são efeitos de políticas que regulam o reconhecimento e diferenciam pessoas e indivíduos como vidas vivíveis, a serem protegidas, e vidas que poderão ser perdidas sem a proteção dos serviços de saúde. Tais políticas permeiam os processos saúde-doença na medida em que modulam modos de existência baseados em normas hegemônicas de viver e existir nos gêneros e sexualidades, que podem produzir sofrimento e adoecimento. Normas alicerçadas numa referência cisheteropatriarcal e racista, que patologizam experiências e vivências não centradas na branquitude, na heteronormatividade e na cisnormatividade.

Abstract Access to health and the elements of the trans population’s health-disease process are analyzed in this article based on Judith Butler’s Public Appearance and Recognition analysis categories. We started from the analysis of interviews with nine transsexual women and seven workers from the same Brazilian transgender health care from the Unified Health System (SUS). We argue that processes of discrimination and disrespect for the social name in health services are effects of policies that regulate the recognition and differentiate people and individuals as liveable lives, to be protected, and lives that may be lost without the protection of health services. These policies permeate the health-disease processes insofar as they modulate modes of existence based on hegemonic norms of living and existing in genders and sexualities, which can produce suffering and illness. Norms based on the cis heteropatriarchal and racist reference, which pathologize experiences not centered on whiteness as a norm, on heteronormativity, and on cisnormativity.

Resumo: Neste artigo trazemos as reflexões etnográficas de dois campos de pesquisa distintos. O objetivo é evidenciar como as estruturas machistas e LGBTfóbicas são vivenciadas por mulheres e também por homens trans durante a prática esportiva futebolística. Sabe-se que os esportes, sobretudo o futebol, são considerados campos privilegiados na produção e reiteração de expressões normativas de masculinidade, visto que tomam o homem cisgênero e heterossexual como o seu natural praticante e interlocutor. Em razão disso, o machismo e a LGBTfobia são estruturantes do campo futebolístico, uma vez que mulheres e pessoas LGBTQI+ são ainda constantemente interpeladas e veem a sua presença nesse campo ser recorrentemente questionada e até mesmo depreciada.

Abstract: This article aims to show some ethnographic reflexes about two anthropological research fields. The objective is to demonstrate how machismo and LGBTphobic structures are experienced by women and by LGBTQI+ people during a football practice. We know that sports, especially football, are considered privileged fields in which exist the production and reiteration of normative expressions of masculinity. Thereat cisgender and heterosexual men are considered their practitioner and natural interlocutor. As a result, machismo and LGBTphobia are structural issues in the football field. Women and LGBTQI+ people are still questioned about their presence in this sport and are also recurrent depreciated.

Resumen: En este artículo aportamos reflexiones etnográficas de dos campos de investigación distintos. El objetivo es poner de manifiesto cómo las estructuras sexistas y LGTBfóbicas son vividas por mujeres y también por los hombres trans durante la práctica del fútbol. Es sabido que los deportes, especialmente el fútbol, son considerados campos privilegiados en la producción y reiteración de las expresiones normativas de la masculinidad, ya que toman al hombre cisgénero y heterosexual como su practicante e interlocutor natural. Por ello, el machismo y la LGTBfobia son estructurales en el campo futbolístico, hasta el punto de que las mujeres y las personas LGTBQI+ siguen siendo constantemente cuestionadas y ven su presencia en este campo frecuentemente cuestionada e incluso depreciada.

ABSTRACT The increasing use of illicit drugs imposes a public health challenge worldwide. People who inject drugs (PWID) are more susceptible to health complications due to immunosuppression associated with drug use and non-hygienic self-administration of substances, contaminants, and liquids. PWID are subjected to increased risk of acquiring and transmitting different pathogens (frequently functioning as sentinel cases for (re)emerging pathogens), including those transmitted by arthropods and vertebrate reservoirs in unhealthy environments. A clear association between injection drug use and HIV, HBV, and HCV infections has been described; however, other infectious viral and bacterial agents have been seldomly assessed. In this study, we investigated the seroprevalence of Bartonella spp., Coxiella burnetii, and Hantavirus among 300 randomly selected PWIDs from Rio de Janeiro, as part of a multi-city cross-sectional study carried out in the 1990s. Point seroprevalences and respective 95% CIs are as follows: 9.3% for C. burnetii (95% CI: 6.0%-13.0%), 1.0% for Bartonella spp. (95% CI: 0.0%-3.0%), and 4.0% for Hantavirus (95% CI: 2.0%-7.0%). In addition to the blood-borne pathogens, the results of this study increase our knowledge on other transmissible infectious agents in PWID. The high seroprevalence of C. burnetii and Hantavirus found among PWID is intriguing and suggests the need to carry out prospective studies, including molecular analyses, to confirm these findings and allow a better understanding of the putative relevance of these zoonotic infectious agents among PWID.

Resumo O presente estudo avaliou nível de atividade física (AF) e seus efeitos associados entre estudantes da rede pública de São Paulo. Um estudo transversal foi feito usando uma amostra representativa de estudantes da rede pública de ensino de São Paulo. Foi utilizado o International Physical Activity Questionnaire para determinar o nível AF. Estudantes que relataram pelo menos 300 minutos/semana de AF, foram considerados ativos. As variáveis independentes foram: sexo, idade, índice de massa corporal, educação, região e o conhecimento do programa Agita São Paulo. A prevalência de AF regular foi de 71,7%. Os meninos (RP = 1,09, IC95% = 1,04 -1,15), 17 anos de idade (RP = 1,16, 95% IC 1,09-1,24), terceiro ano do ensino médio (RP = 1,20, IC95% = 1,12-1,29 ) e aqueles que residiam na região do Centro-Oeste (RP = 1,27, IC95% 1,16-1,38) tinham maior probabilidade de ser ativos. Meninos de 17 anos de idade, no terceiro ano do ensino médio, que residiam no Centro-Oeste e reconhecia o programa Agita São Paulo/Agita Galera tinham níveis mais elevados de AF. Alunos de São Paulo apresentaram um elevado nível de AF. Meninos com idade superior a 17 anos, do 3º ano do ensino médio, que residiam na região Centro-Oeste, e reconhecia o programa Agita São Paulo/Agita Galera foram mais propensos a ser mais ativos.

Abstract The current study evaluated physical activity (PA) level and its associated effects among students in the public network of São Paulo, Brazil. A cross-sectional study was taken using a representative sample of students in São Paulo public school system. International Physical Activity Questionnaire determined PA level. Students who reported at least 300 minutes/week of PA were considered active. The independente variables were: gender, age, body mass index, education, region, recognition of the Agita São Paulo program. The prevalence of regular PA was 71.7%. Males (PR = 1.09, 95% CIs = 1.04 -1.15) at least 17 years old (PR = 1.16, 95% CIs 1.09-1.24) in their 3rd year of high school (PR = 1.20, 95% CIs = 1.12-1.29) who resided in the Midwest region (PR = 1.27, 95% CIs 1.16-1.38) were most likely to be active. Males at least 17 years old in their 3rd year of high school who lived in the Midwest and recognized the Agita São Paulo/Agita Galera program had higher levels of PA. São Paulo students presented a high level of PA. Moreover, males older than 17 years, attending their 3rd year of high school, who lived in the Midwest region, and recognized the Agita São Paulo/Agita Galera program were the most likely to be more active.

Resumo O presente estudo avaliou nível de atividade física (AF) e seus efeitos associados entre estudantes da rede pública de São Paulo. Um estudo transversal foi feito usando uma amostra representativa de estudantes da rede pública de ensino de São Paulo. Foi utilizado o International Physical Activity Questionnaire para determinar o nível AF. Estudantes que relataram pelo menos 300 minutos/semana de AF, foram considerados ativos. As variáveis independentes foram: sexo, idade, índice de massa corporal, educação, região e o conhecimento do programa Agita São Paulo. A prevalência de AF regular foi de 71,7%. Os meninos (RP = 1,09, IC95% = 1,04 -1,15), 17 anos de idade (RP = 1,16, 95% IC 1,09-1,24), terceiro ano do ensino médio (RP = 1,20, IC95% = 1,12-1,29 ) e aqueles que residiam na região do Centro-Oeste (RP = 1,27, IC95% 1,16-1,38) tinham maior probabilidade de ser ativos. Meninos de 17 anos de idade, no terceiro ano do ensino médio, que residiam no Centro-Oeste e reconhecia o programa Agita São Paulo/Agita Galera tinham níveis mais elevados de AF. Alunos de São Paulo apresentaram um elevado nível de AF. Meninos com idade superior a 17 anos, do 3º ano do ensino médio, que residiam na região Centro-Oeste, e reconhecia o programa Agita São Paulo/Agita Galera foram mais propensos a ser mais ativos.

Abstract The current study evaluated physical activity (PA) level and its associated effects among students in the public network of São Paulo, Brazil. A cross-sectional study was taken using a representative sample of students in São Paulo public school system. International Physical Activity Questionnaire determined PA level. Students who reported at least 300 minutes/week of PA were considered active. The independente variables were: gender, age, body mass index, education, region, recognition of the Agita São Paulo program. The prevalence of regular PA was 71.7%. Males (PR = 1.09, 95% CIs = 1.04 -1.15) at least 17 years old (PR = 1.16, 95% CIs 1.09-1.24) in their 3rd year of high school (PR = 1.20, 95% CIs = 1.12-1.29) who resided in the Midwest region (PR = 1.27, 95% CIs 1.16-1.38) were most likely to be active. Males at least 17 years old in their 3rd year of high school who lived in the Midwest and recognized the Agita São Paulo/Agita Galera program had higher levels of PA. São Paulo students presented a high level of PA. Moreover, males older than 17 years, attending their 3rd year of high school, who lived in the Midwest region, and recognized the Agita São Paulo/Agita Galera program were the most likely to be more active.

Abstract Mesenchymal stem cells (MSCs) are known for their important properties involving multilineage differentiation potential., trophic factor secretion and localization along various organs and tissues. On the dark side, MSCs play a distinguished role in tumor microenvironments by differentiating into tumor-associated fibroblasts or supporting tumor growth via distinct mechanisms. Cisplatin (CIS) is a drug widely applied in the treatment of a large number of cancers and is known for its cytotoxic and genotoxic effects, both in vitro and in vivo. Here we assessed the effects of CIS on MSCs and the ovarian cancer cell line OVCAR-3, by MTT and comet assays. Our results demonstrated the resistance of MSCs to cell death and DNA damage induction by CIS, which was not observed when OVCAR-3 cells were exposed to this drug.