Abstract This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants.

RESUMO Com o objetivo de analisar a atuação das equipes multiprofissionais conformadas nos Núcleos Ampliados de Apoio à Família e Atenção Básica, frente às dimensões clínico-assistencial e técnico-pedagógica no contexto da Atenção Primária à Saúde no Brasil, delineou-se estudo multicêntrico, de natureza qualitativa, realizado no período de 2018 a 2020, em três municípios no estado do Ceará. A coleta de dados ocorreu através de observação e grupo focal com as equipes multiprofissionais. Os registros das observações e dos discursos dos grupos focais foram tabulados no software Interface de R pour L Analyses Multidimensionnelles de Textes L de Questionnaires (IRAMUTEQ®). Na Classificação Hierárquica Descendente, obteve-se um aproveitamento de 75,46% do corpus textual, formando cinco classes, cujos vocábulos têm associação estatisticamente relevante (p<0,0001). Os resultados evidenciam avanços na atuação das equipes multiprofissionais na produção do cuidado integral dos indivíduos e coletivos, a partir de ações de planejamento e tomada de decisões partilhadas com vistas à melhoria da qualidade de vida destes. Outrossim, identifica-se uma ênfase na dimensão clínico- -assistencial do cuidado, o que torna a dimensão técnico-pedagógica um desafio. Contudo, reconhece-se o potencial indutor da atuação das equipes para um trabalho colaborativo e orientado pela interprofissionalidade, corroborando o fortalecimento da Atenção Primária à Saúde.

ABSTRACT In order to analyze the performance of the multiprofessional teamwork at the Family Primary Health Care Expanded Support Centers, regarding the clinical-assistance and technical-pedagogical dimensions in Brazilian Primary Health Care, a multicentered study was outlined. This study is qualitative and descriptive in nature, and it was carried out between 2018 and 2020 in three northeast Brazilian towns. Data were collected through observation and focus groups with multiprofessional teams which worked in Primary Health Care. Observations were made during the baseline phase, follow-ups one and two. Documentation of observations and focal group’s speech were tabulated using the Interface de R pour L Analyses Multidimensionnelles de Textes L de Questionnaires (IRAMUTEQ®) software. 106 text units were identified in the Descending Hierarchical Classification, with 807 follow-ups, 28.304 occurrences, 1.809 active forms with average frequency ≥3:737, chi2≥57,64, and 75.46% use of textual statistics, which formed five classes of statistically relevant words (p<0,0001). The results show advances in the work done by the multiprofessional teams on the production of comprehensive care of both individuals and collectivity, due to action plans and collaborative decision seeking improvements in the quality of life of individuals and collectivity. It is also possible to identify emphasis on the clinical-assistance dimension of care and that makes the technical-pedagogical dimension a challenge. However, we highlight the teams’ collaborative driving force that was guided by the interprofessionality, corroborating, thus, the strengthening of Primary Health Care.

RESUMO Com o objetivo de analisar a atuação das equipes multiprofissionais conformadas nos Núcleos Ampliados de Apoio à Família e Atenção Básica, frente às dimensões clínico-assistencial e técnico-pedagógica no contexto da Atenção Primária à Saúde no Brasil, delineou-se estudo multicêntrico, de natureza qualitativa, realizado no período de 2018 a 2020, em três municípios no estado do Ceará. A coleta de dados ocorreu através de observação e grupo focal com as equipes multiprofissionais. Os registros das observações e dos discursos dos grupos focais foram tabulados no software Interface de R pour L Analyses Multidimensionnelles de Textes L de Questionnaires (IRAMUTEQ®). Na Classificação Hierárquica Descendente, obteve-se um aproveitamento de 75,46% do corpus textual, formando cinco classes, cujos vocábulos têm associação estatisticamente relevante (p<0,0001). Os resultados evidenciam avanços na atuação das equipes multiprofissionais na produção do cuidado integral dos indivíduos e coletivos, a partir de ações de planejamento e tomada de decisões partilhadas com vistas à melhoria da qualidade de vida destes. Outrossim, identifica-se uma ênfase na dimensão clínico- -assistencial do cuidado, o que torna a dimensão técnico-pedagógica um desafio. Contudo, reconhece-se o potencial indutor da atuação das equipes para um trabalho colaborativo e orientado pela interprofissionalidade, corroborando o fortalecimento da Atenção Primária à Saúde.

ABSTRACT In order to analyze the performance of the multiprofessional teamwork at the Family Primary Health Care Expanded Support Centers, regarding the clinical-assistance and technical-pedagogical dimensions in Brazilian Primary Health Care, a multicentered study was outlined. This study is qualitative and descriptive in nature, and it was carried out between 2018 and 2020 in three northeast Brazilian towns. Data were collected through observation and focus groups with multiprofessional teams which worked in Primary Health Care. Observations were made during the baseline phase, follow-ups one and two. Documentation of observations and focal group’s speech were tabulated using the Interface de R pour L Analyses Multidimensionnelles de Textes L de Questionnaires (IRAMUTEQ®) software. 106 text units were identified in the Descending Hierarchical Classification, with 807 follow-ups, 28.304 occurrences, 1.809 active forms with average frequency ≥3:737, chi2≥57,64, and 75.46% use of textual statistics, which formed five classes of statistically relevant words (p<0,0001). The results show advances in the work done by the multiprofessional teams on the production of comprehensive care of both individuals and collectivity, due to action plans and collaborative decision seeking improvements in the quality of life of individuals and collectivity. It is also possible to identify emphasis on the clinical-assistance dimension of care and that makes the technical-pedagogical dimension a challenge. However, we highlight the teams’ collaborative driving force that was guided by the interprofessionality, corroborating, thus, the strengthening of Primary Health Care.

RESUMO Água residuária têxtil foi tratada com Aspergillus niger AN 400 em reator de bateladas sequenciais, em ciclos de 48 h para avaliar o efeito de fonte adicional de nitrogênio sobre a eficiência do sistema alimentado com efluente diluído (10% v/v) e glicose (3 g.L-1). O afluente recebeu fonte adicional de nitrogênio (etapa I), acarretando em excesso de nitrogênio amoniacal (192 mg.L-1) no meio, resultando em remoção de matéria orgânica de 85%, porém em apenas 55% de remoção de corante. Ao se diminuir a concentração média de amônia para 98 mg.L-1 (etapa II), a remoção de corante (83%) passou a ser superior à de matéria orgânica, de 69%, mostrando o efeito negativo de concentrações elevadas de amônia sobre o sistema, favorecendo ainda o crescimento de bactérias, o que provavelmente inibiu a produção de enzimas fúngicas e contribuiu para a perda de eficiência na remoção de corante e formação de subprodutos.

ABSTRACT Textile wastewater was treated by Aspergillus niger AN 400 in sequential batch reactor, which was operated in cycles of 48 h in order to evaluate the effect of an additional source of nitrogen on the system's efficiency, which was fed with effluent diluted (10% v/v) and glucose (3 g.L-1). The influent received addition of an external source of nitrogen (phase I), in which there was excess ammonia (192 mg.L-1) in the medium, resulting in organic matter removal of 85%, but in only 55% removal of dye. In the phase II, when the average concentration of ammonia in the medium was lower (98 mg.L-1), removal of dye (83%) became higher than that of organic matter (69%), showing the negative effect of high concentrations of ammonia over the system and favoring the growth of bacteria, which probably inhibit the production of fungal enzymes and contributed to the loss of efficiency in the removal of dye and the formation of byproducts.