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Abstract Pygocentrus nattereri is a widely distributed species in the Neotropical region and a potential bio-indicator. Kidneys have functions in fish physiology, allowing them to live in different environments. We aimed to compare the histological characteristics of caudal kidneys between males and females, associating them with the renosomatic index (RSI). For this purpose, 15 males and 14 females were used for biometric and histological analyses. Structural volumetric density (SVD), renal corpuscle histometric measures, and hemosiderin and lipofuscin deposit frequency in macrophages melanogenic (MMs) were assessed. No biometric differences were observed between the sexes, but body weight and standard length were correlated with RSI. The SVD showed difference in hematopoietic tissue between female and males, whereas the density of the other structures was not different. The RSI was positively associated with hematopoietic tissue and proximal tubule density in contrast to distal tubules, blood vessels, collecting ducts and MMs. Females exhibited a higher renal corpuscle area, glomerulus area, distal tubule diameter, collecting tubule area, and collecting tubule lumen area. These differences may be due to metabolic differences between males and females. Sex effect in P. nattereri may define punctual differences in future studies on the metabolism and immunity of this species.

Resumo Pygocentrus nattereri é uma espécie amplamente distribuída na região Neotropical e pode ser considerada como um potencial bioindicador ambiental. Os rins têm funções cruciais na fisiologia dos peixes, permitindo-lhes viver em diferentes ambientes. Nosso objetivo foi comparar as características histológicas dos rins excretores entre machos e fêmeas, associando-as ao índice renossomático (IRS). Para tanto, 15 machos e 14 fêmeas foram utilizados para análises biométricas e histológicas. Amostras do tecido renal foram processadas para densidade estrutural volumétrica, medidas histométricas do corpúsculo renal e frequência dos depósitos de hemossiderina e lipofuscina nos macrófagos melonogênicos (MMs). Não foram observadas diferenças biométricas entre os sexos, mas a massa corporal e o comprimento padrão foram correlacionados com IRS. Apenas a densidade estrutural volumétrica do tecido hematopoiético foi diferente entre machos e fêmeas. Não houve diferença nas demais estruturas. O IRS associou-se positivamente com o tecido hematopoiético e densidade dos túbulos proximais e negativamente com os túbulos distais, vasos sanguíneos, ductos coletores e MMs. As fêmeas apresentaram maior área do corpúsculo renal, área do glomérulo, diâmetro do túbulo distal, área do túbulo coletor e área do lúmen do túbulo coletor. Essas diferenças podem ser devida às diferenças metabólicas entre machos e fêmeas. Particularidade do efeito de sexo em P. nattereri pode definir diferenças pontuais em futuros estudos sobre o metabolismo e imunidade nesta espécie.

https://doi.org/10.1590/1982-0224-2022-0108

Photocatalytic Degradation of the Rhodamine B Dye Under Visible Light Using NixCu(1-x)Fe2O4 Synthesized by EDTA-Citrate Complexation Method
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Azevedo, Ila G. D. D. de

; Rodrigues, Matheus V.

; Gomes, Yara F.

; Araújo, Camila P. B. de

; Souza, Carlson P. de

; Moriyama, André L. L.

Materials Research

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2023, Volume 26 Supl. 1 elocation e20230061

Resumo: En | Texto: En | PDF: En

The NixCu(1-x)Fe2O4 (x = 0, 0.2, 0.8, 1) mixed nickel and copper ferrites were synthesized using the EDTA-Citrate complexation method and calcined at 700°C. The structure, properties and characterization of the samples were analyzed by DRX, Rietveld refinement, SEM, and DRE UV-Vis, indicating the phase formation of tetragonal (CuFe2O4 and Ni0.2Cu0.8Fe2O4) and cubic (Ni0.8Cu0.2Fe2O4 and NiFe2O4). The materials exhibited morphologies suitable for photocatalytic applications and a UV-Vis absorption range near 2 eV as expected for spinel ferrites. These materials were evaluated as photocatalysts for the degradation of Rhodamine B dye under heterogeneous photocatalysis conditions, simulating solar light irradiation, air injection, and different pH levels (2, 6, and 10). The results showed that the catalytic efficiency was higher for samples with a higher copper content and in a basic medium. Therefore, NixCu(1-x)Fe2O4 mixed ferrites have promising potential as photocatalysts.

https://doi.org/10.1590/1980-5373-mr-2023-0061

Chickpea seed storage in different packagings, environments and periods
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Silva, Amanda M.

; Figueiredo, Josiane C.

; Tunes, Lilian V. M. de

; Gadotti, Gizele I.

; Rodrigues, Daniele B.

; Capilheira, André F.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Set 2022, Volume 26 Nº 9 Páginas 649 - 654

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O armazenamento é uma prática fundamental no controle da qualidade fisiológica das sementes, pois é um método que pode preservar sua viabilidade e vigor por mais tempo. Assim, o objetivo do presente estudo foi avaliar o armazenamento de sementes de grão-de-bico em diferentes embalagens, ambientes e períodos. O delineamento inteiramente casualizado foi utilizado em esquema fatorial 2 × 2 × 4, sendo dois tipos de embalagens (hermética e papel Kraft®), dois ambientes de armazenamento (ambiente de câmara fria e ambiente convencional) e quatro períodos de armazenamento (0, 45, 90 e 135 dias), com quatro repetições. As sementes foram acondicionadas em sacos de papel Kraft® e embalagens herméticas, e armazenadas por 135 dias nos ambientes: câmara fria (14,5 °C e umidade relativa do ar de 65%) e ambiente convencional (sem controle de temperatura e umidade relativa do ar). A cada 45 dias, as sementes foram submetidas às seguintes avaliações: determinação do teor de água, germinação, primeira contagem de germinação e envelhecimento acelerado. Em geral, a manutenção da qualidade fisiológica das sementes de grão de bico foi verificada em embalagens de papel Kraft® e em ambiente de câmara fria. O armazenamento de sementes de grão de bico em embalagens herméticas deve ser realizado com sementes com 7% de umidade, independente do ambiente de armazenamento. As embalagens mantiveram a qualidade fisiológica das sementes de grão de bico por até 45 dias, independente do ambiente de armazenamento.

ABSTRACT Storage is a fundamental practice in the control of the physiological quality of seeds, as it is a method that can preserve their viability and vigor for a longer period. Thus, the objective of the present study was to evaluate the storage of chickpea seeds in different packagings, environments, and periods. The completely randomized design was used in a 2 × 2 × 4 factorial scheme, corresponding to two types of packaging (hermetic and Kraft® paper), two storage environments (cold chamber environment and conventional environment), and four storage periods (0, 45, 90, and 135 days), with four replicates. The seeds were placed in Kraft® paper bags and hermetic packagings and stored for 135 days in the environments: cold chamber (14.5 °C and relative air humidity of 65%) and conventional environment (no temperature and relative air humidity control). Every 45 days, seeds were subjected to the following evaluations: determination of water content, germination, first germination count and accelerated aging. In general, the maintenance of the physiological quality of chickpea seeds was verified in Kraft® paper packagings and the cold chamber environment. Storage of chickpea seeds in hermetic packaging must be carried out with seeds with 7% moisture, regardless of the storage environment. The packagings maintained the physiological quality of chickpea seeds for up to 45 days, regardless of the storage environment.

https://doi.org/10.1590/1807-1929/agriambi.v26n9p649-654

Non-Ionizing Radiation Analysis in Close Proximity to Antenna Tower: A Case Study in Northeast Brazil
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Diniz, Andre B. de F.

; Sousa Jr., Vicente A. de

; Rodrigues, Marcio E. C.

; Mendonça, Halysson B.

; Silva, Gutembergue Soares da

; Pinheiro, Fred Sizenando Rossiter

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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Mar 2021, Volume 20 Nº 1 Páginas 126 - 142

Resumo: En | Texto: En | PDF: En

Abstract While the amount of telecommunications services grows rapidly in the whole world, humans get potentially more exposed to Non-Ionizing Radiation (NIR) from a number of different sources. Measurements of NIR levels are relevant in order to compare the results with national and international standards, aiming at the preservation of human health. Thus, it is of great interest to explore a variety of topics regarding this subject. Based on this need, this paper has a number of goals, including monitoring radiation levels in an everyday situation, an investigation of how national and international regulations organs address NIR levels and a demonstration of scientific production trends regarding this topic. The work also presents a bibliometric study about the main scientific productions and trends related to NIR measurements, with focus on the field of Telecommunications. The analysis is based on the databases of Web of Science (WOS) and Scopus, computing publications in the last 10 and 3 years, showing a trend evaluation. Among the main results from this exploratory investigation, there is an exponential growth in the number of publications about NIR, ranging from research in physics to medicine. The way research contribution in different countries is also shown, in order to support the relevance of the topic in defining new tendencies for new investigations. Furthermore, the NIR exposure limits and measurement criteria are presented both in Brazilian and in international norms, demonstrating how different national regulations can be when compared to international guidelines. Another contribution is a case study in Natal, Brazil, where NIR levels were monitored in four distinct locations over a period of 24 hours each and compared to the current regulations. The result is a quantitative analysis of the amount of radiation that some populations might be exposed to in distinct moments of the day. Measurements were carried out in the proximity of an antenna spot, since it could represent a source of high NIR levels (a worst case of human exposure). This campaign differs from older studies by including a more intense usage of microwaves frequencies due to operating 4G and pre-5G systems in Brazil. Finally, a statistical study involving the measurements is conducted, concluding the analysis of how some population groups might be affected by NIR.

https://doi.org/10.1590/2179-10742021v20i1833 361 downloads

Antileishmanial Acetylene Fatty Acid and Acetogenins from Seeds of Porcelia macrocarpa
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Brito, Ivanildo A.

; Oliveira, Emerson A.

; Chaves, Mariana H.

; Thevenard, Fernanda

; Rodrigues-Oliveira, André F.

; Barbosa-Reis, Gustavo

; Sartorelli, Patricia

; Oliveira-Silva, Diogo

; Tempone, Andre G.

; Costa-Silva, Thais A.

; Lago, João Henrique G.

Journal of the Brazilian Chemical Society

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Fev 2021, Volume 32 Nº 2 Páginas 447 - 453

Resumo: En | Texto: En | PDF: En

In the present work five acetylene derivatives (1-5), including three unknowns (1, 3 and 4), were isolated from seeds of Porcelia macrocarpa (Annonaceae). The structures of isolated compounds were determined as docos-13-yn-21-enoic acid (1), 3-hydroxy-4-methylene-2-(eicos-11’-yn-19’-enyl)but-2-enolide (2), 3-hydroxy-4-methylene-2-(octadec-9’-yn-17’-enyl)but-2-enolide (3), 3-hydroxy-4-methylene-2-(hexadec-7’-yn-15’-enyl)but-2-enolide (4), and (2S,3R,4R)-3-hydroxy-4-methyl-2-(eicos-11’-yn-19’-enyl)butanolide (5) by analysis of nuclear magnetic resonance (NMR) and electrospray ionization high-resolution mass spectrometry (ESI-HRMS) data. Moreover, all isolated compounds demonstrated selectivity towards intracellular amastigotes of Leishmania (L.) infantum, especially 2-4 with 50% inhibitory concentration (IC50) values of 9.2, 10.4 and 11.0 µM, respectively, indicating superior activity of that determined to positive control miltefosine (IC50 of 17.8 µM). Furthermore, these compounds showed higher selectivity index (SI) in comparison with miltefosine. Since related acetylene fatty acid 1 displayed reduced antiparasitic potential (IC50 of 48.5 µM), the obtained results suggested that the γ-lactone plays an important role in the antileishmanial activity. However, 2-4 exhibited cytotoxicity to mammalian NCTC cells (CC50 ca. 80 µM), which could be a result of the presence of a conjugated carbonyl system in the lactone ring, since 5, the only acetogenin that presents the saturated ring, lacked mammalian cytotoxicity (CC50 > 200 µM).

https://doi.org/10.21577/0103-5053.20200197 231 downloads

Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
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Bocchi, Edimar Alcides

; Moreira, Henrique Turin

; Nakamuta, Juliana Sanajotti

; Simões, Marcus Vinicius

; Casas, Alberto de Almeida Las

; Costa, Altamiro Reis da

; Assis, Amberson Vieira de

; Durães, André Rodrigues

; Pereira-Barretto, Antonio Carlos

; Ravessa, Antonio Delduque de Araujo

; Macedo, Ariane Vieira Scarlatelli

; Biselli, Bruno

; Pinto, Carolina Maria Nogueira

; Filho, Conrado Roberto Hoffmann

; Costantini, Costantino Roberto

; Almeida, Dirceu Rodrigues

; Santos Jr, Edval Gomes dos

; Soliva Junior, Erwin

; Figueiredo, Estevão Lanna

; Albuquerque, Felipe Neves de

; Paulitsch, Felipe

; Neuenschwander, Fernando Carvalho

; Figueiredo Neto, José Albuquerque de

; Brito, Flavio de Souza

; Lopes, Heno Ferreira

; Villacorta, Humberto

; Souza Neto, João David de

; Sepulveda, João Mariano

; Ayoub, José Carlos Aidar

; Vilela-Martin, José F.

; Cardoso, Juliano Novaes

; Uemura, Laercio

; Moura, Lidia Zytynski

; Maia, Lilia Nigro

; Oliveira, Lucia Brandão de

; Maia, Lucimir

; Silva, Luís Beck da

; Gowdak, Luís Henrique Wolff

; Danzmann, Luiz Claudio

; Andrade, Marcus

; Braile-Sternieri, Maria Christiane Valeria Braga

; Moreira, Maria da Consolação Vieira

; França Neto, Olimpio R

; Filho, Otavio Rizzi Coelho

; Esteves, Paulo Frederico

; Raupp-da-Rosa, Priscila

; Silva, Ricardo Jorge de Queiroz e

; Mourilhe-Rocha, Ricardo

; Viégas, Ruy Felipe Melo

; Rassi, Salvador

; Mangili, Sandrigo

; Kaiser, Sergio Emanuel

; Martins, Silvia Marinho

; Kawabata, Vitor Sergio

Clinics

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2021, Volume 76 elocation e1991

Resumo: En | Texto: En | PDF: En

OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.

https://doi.org/10.6061/clinics/2021/e1991 870 downloads

β-glucosidase from thermophilic fungus Thermoascus crustaceus: production and industrial potential
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GARBIN, ANDREZA P.

; GARCIA, NAYARA F.L.

; CAVALHEIRO, GABRIELA F.

; SILVESTRE, MARIA ALICE

; RODRIGUES, ANDRÉ

; PAZ, MARCELO F. DA

; FONSECA, GUSTAVO G.

; LEITE, RODRIGO S.R.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 1 elocation e20191349

Resumo: En | Texto: En | PDF: En

Abstract Microbial β-glucosidases can be used in several industrial processes, including production of biofuels, functional foods, juices, and beverages. In the present work, production of β-glucosidase by solid state cultivation of the fungus Thermoascus crustaceus in a low-cost cultivation medium (comprising agroindustrial residues) was evaluated. The highest production of β-glucosidase, about 415.1 U/g substrate (or 41.51 U/mL), was obtained by cultivating the fungus in wheat bran with 70% humidity, during 96 h at 40°C. The enzymatic activity was optimum at pH 4.5 and 65°C. β-Glucosidase maintained its catalytic activity when incubated at a pH range of 4.0-8.0 and temperature of 30-55°C. The enzyme was strongly inhibited by glucose; even when the substrate and glucose concentrations were equal, the inhibition was not reversed, suggesting a non-competitive inhibition. In the presence of up to 10% ethanol, β-glucosidase maintained its catalytic activity. In addition to β-glucosidase, the enzymatic extract showed activity of 36 U/g for endoglucanase, 256.2 U/g for xylanase, and 18.2 U/g for β-xylosidase. The results allow to conclude that the fungus T. crustaceus has considerable potential for production of β-glucosidase and xylanase when cultivated in agroindustrial residues, thereby reducing the cost of these biocatalysts.

https://doi.org/10.1590/0001-3765202120191349 566 downloads

Age-associated hemogram and ultrastructural leukocyte morphology in Pygocentrus nattereri (Characiformes: Serrasalmidae) from the Brazilian Pantanal
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Siqueira, Mayara S.

; Leão, Taynara R. F.

; Rodrigues, Robson A.

; Farias, Karine N. N.

; Silva, André L. N.

; Marcondes, Sandriely F.

; Veiga, Marcelo L.

; Franco-Belussi, Lilian

; Fernandes, Carlos E.

Neotropical Ichthyology

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2021, Volume 19 Nº 1 elocation e200136

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Pygocentrus nattereri é um peixe carnívoro amplamente distribuído no pantanal brasileiro e ocupa diferentes estratos de rios. Com base na maturidade sexual, o comprimento padrão (CP) tem sido usado para categorizar a idade e os atributos fisiológicos. No entanto, os parâmetros hematológicos e sua relação com a idade e características de crescimento são desconhecidos. O objetivo foi avaliar o perfil hematológico e leucocitário de espécimes juvenis e adultos, associando-o ao CP. Espécimes de ambos os sexos foram pesados e os CPs foram medidos para classificação em juvenis (CP ≤16,0 cm) e adultos (CP ≥16,1 cm). Foi coletado sangue para realização do hemograma, perfil e morfologia dos leucócitos. Em geral, os valores do hemograma e as contagens de leucócitos, linfócitos e monócitos foram maiores nos jovens. A contagem de trombócitos e neutrófilos foi maior em adultos do que em jovens. A análise ultraestrutural mostrou que a contagem de leucócitos granulares em P. nattereri foi semelhante a outros peixes. Os leucócitos granulares PAS-positivos são menores do que os neutrófilos, sendo caracterizados por formas alongadas e semilunares densas no citoplasma. Nossos resultados sugerem que CP é útil para a análise da relação entre o estado de saúde de P. nattereri em ambientes aquáticos alagados.

ABSTRACT Pygocentrus nattereri is a carnivorous fish widely distributed in the Brazilian wetland and occupies different river strata. Based on the sexual maturity, the standard length (SL) has been used to categorize age and physiological attributes. However, hematological parameters and their relationship with age and growth features are unknow. Here, the aim was to evaluate the hematological profile and leukocyte data of juvenile and adult specimens, associating it with SL. Specimens of both sexes were weighted, and SL were measured for classify as juveniles (SL ≤16.0 cm) and adults (SL ≥16.1 cm). Blood was collected to perform the hemogram, for leukocyte quantification and ultrastructural descriptions. In general, hemogram values and leukocyte, lymphocyte, and monocyte counts were high in juveniles. Hemogram variables were negatively correlated with SL. Thrombocyte and neutrophil counts were higher in adults than in juveniles. SL was correlated with leukogram variables. Ultrastructural analysis showed that granular leukocyte count in P. nattereri was similar another fishes. PAS-positive granular leukocytes are slightly smaller than neutrophils and are characterized by dense elongated and semi-lunar shapes in the cytoplasm. Our results suggest that age-based SL may be useful for the analysis of the relationship between P. nattereri health status and wetland aquatic environments.

https://doi.org/10.1590/1982-0224-2020-0136 455 downloads

Diretriz Brasileira de Cardio-oncologia – 2020
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Hajjar, Ludhmila Abrahão

; Costa, Isabela Bispo Santos da Silva da

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Hoff, Paulo Marcelo Gehm

; Diz, Maria Del Pilar Estevez

; Fonseca, Silvia Moulin Ribeiro

; Bittar, Cristina Salvadori

; Rehder, Marília Harumi Higuchi dos Santos

; Rizk, Stephanie Itala

; Almeida, Dirceu Rodrigues

; Fernandes, Gustavo dos Santos

; Beck-da-Silva, Luís

; Campos, Carlos Augusto Homem de Magalhães

; Montera, Marcelo Westerlund

; Alves, Sílvia Marinho Martins

; Fukushima, Júlia Tizue

; Santos, Maria Verônica Câmara dos

; Negrão, Carlos Eduardo

; Silva, Thiago Liguori Feliciano da

; Ferreira, Silvia Moreira Ayub

; Malachias, Marcus Vinicius Bolivar

; Moreira, Maria da Consolação Vieira

; Valente Neto, Manuel Maria Ramos

; Fonseca, Veronica Cristina Quiroga

; Soeiro, Maria Carolina Feres de Almeida

; Alves, Juliana Barbosa Sobral

; Silva, Carolina Maria Pinto Domingues Carvalho

; Sbano, João

; Pavanello, Ricardo

; Pinto, Ibraim Masciarelli F.

; Simão, Antônio Felipe

; Dracoulakis, Marianna Deway Andrade

; Hoff, Ana Oliveira

; Assunção, Bruna Morhy Borges Leal

; Novis, Yana

; Testa, Laura

; Alencar Filho, Aristóteles Comte de

; Cruz, Cecília Beatriz Bittencourt Viana

; Pereira, Juliana

; Garcia, Diego Ribeiro

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

; Macedo, Ariane Vieira Scarlatelli

; Marcatti, Patricia Tavares Felipe

; Mathias Junior, Wilson

; Wiermann, Evanius Garcia

; Val, Renata do

; Freitas, Helano

; Coutinho, Anelisa

; Mathias, Clarissa Maria de Cerqueira

; Vieira, Fernando Meton de Alencar Camara

; Sasse, André Deeke

; Rocha, Vanderson

; Ramires, José Antônio Franchini

; Kalil Filho, Roberto

Arquivos Brasileiros de Cardiologia

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Nov 2020, Volume 115 Nº 5 Páginas 1006 - 1043

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201006 4180 downloads

10.

Quality of Life (QoL) Among Ostomized Patients - a cross-sectional study using Stoma-care QoL questionnaire about the influence of some clinical and demographic data on patients' QoL
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Silva, José O.

; Gomes, Pedro

; Gonçalves, David

; Viana, Charlene

; Nogueira, Fernanda

; Goulart, André

; Leão, Pedro

; Mota, Maria José

; Peixoto, Palmira

; Rodrigues, António Mesquita

; Martins, Sandra F.

Journal of Coloproctology (Rio de Janeiro)

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Mar 2019, Volume 39 Nº 1 Páginas 48 - 55

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Em Portugal estima-se que cerca de 20.000 indivíduos sejam portadores de estoma, com todas as alterações associadas que podem comprometer a sua Qualidade de Vida (QdV). Objectivos: Avaliar a QdV de doentes ostomizados de acordo com o sexo, idade, tipo de cirurgia, doença primária, duração e tipo de estoma. Materiais e métodos: Foram incluídos todos os avaliados na consulta de Estomatoterapia entre Janeiro e Maio de 2017. A avaliação da QdV foi efetuada com recurso ao Questionário de QdV Stoma care. Avaliaram-se quatro domínios: autoestima e autoimagem (SeSi); relação com família e amigos (FF) relação com sono e cansaço e inseguranças relacionada com funcionamento do dispositivo (DeF). Resultados: Doentes com urostomia apresentaram Scores Total, SeSi e FF, significativamente superior a doentes com colostomia e ileostomia. Relativamente ao score SeSi, os doentes com idade igual ou superior a 70 anos e doença maligna apresentaram scores significativamente maiores que os mais jovens e com doenças benignas, respectivamente. Quanto ao score FF verificou-se que doentes com causas malignas apresentaram scores significativamente superiores aos com causas benignas. Conclusões: Doente ileostomizados e colostomizados apresenta QdV significativamente inferior aos doentes com urostomia, sobretudo devido ao impacto nas relações sociais, auto-estima e auto-imagem.

ABSTRACT Introduction: In Portugal around 20,000 individuals are ostomized, with all the associated changes in patients' everyday life that can compromise their Quality of Life (QoL). Objectives: Assess and compare QoL of a group of ostomized patients according to sex, age group, type of surgery, primary disease, stoma duration and stoma type. Material and methods: Ostomized patients observed in Stomatherapy department in between January 1st and May 30th 2017 was enrolled. QoL was assessed using the questionnaire Stoma Care QoL Questionnaire). Four domains were evaluated: Self-esteem and Self-image - SeSi Score; relation with Family and Friends - FF Score; relation with Sleep and Fatigue - SF score and ostomy Device Functioning insecurities - DeF score. Results: Urostomy patients had significantly higher Total Scores, SeSi and FF scores than colostomy and ileostomy patients. Regarding SeSi Score, patients aged 70 years old or more and malignant diseases presented significantly higher scores than their younger counterparts and benign causes, respectively. FF Score document that patients with malignant diseases have significantly higher scores than patients with benign diseases. Conclusions: Ileostomy and colostomy patients have a significantly lower QoL than urostomy patients mostly because of its impact on social relations and self-esteem and self-image.

https://doi.org/10.1016/j.jcol.2018.10.006 1665 downloads

11.

Pyrazolyl-Tetrazoles and Imidazolyl-Pyrazoles as Potential Anticoagulants and their Integrated Multiplex Analysis Virtual Screening
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Lourenço, André L. P. G.

; Vegi, Percilene F.

; Faria, Jéssica V.

; Pinto, Gustavo S. P.

; Santos, Maurício S. dos

; Sathler, Plínio C.

; Saito, Max S.

; Santana, Marcos

; Dutra, Tatiana P. P.

; Rodrigues, Carlos R.

; Monteiro, Robson Q.

; Bernardino, Alice M. R.

; Castro, Helena C.

Journal of the Brazilian Chemical Society

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Jan 2019, Volume 30 Nº 1 Páginas 33 - 47

Resumo: En | Texto: En | PDF: En

This article reports a novel virtual screening algorithm seeking the rational identification of novel lead anticoagulants. Seven 5-(3-methyl-1-aryl-1H-pyrazol-4-yl)-1H-tetrazoles and seven novel 1-aryl-4-(4,5-dihydro-1H-imidazol-2-yl)-3-methyl-1H-pyrazoles were obtained in three steps starting from arylhydrazine hydrochlorides as raw materials in good yields: 50-72% and 50-85%, respectively. All compounds were submitted to an in silico target-base pipeline named integrated multiplex analysis virtual screening (IMA-VS), which comprises the evaluation of their (i) fitting physicochemical properties to the chemical environment of the target enzyme; (ii) active-site homing electrostatic potential to the target enzyme; (iii) structural fitting to the target active site through molecular docking; and (iv) overall absorption, distribution, metabolism, excretion and toxicity (ADMET) profile. After the virtual selection of potential anticoagulant hits, all molecules were synthesized and candidates were evaluated in vitro for their anticoagulant and hemolytic profile. The most promising candidate pointed out by IMA-VS was compound 1-(3',4'-dichlorophenyl)-4-(4,5-dihydro-1H-imidazol-2-yl)-3-methyl-1H-pyrazole that shown to display factor Xa (FXa)-specific inhibitory activity in vitro, acting as an uncompetitive inhibitor with an inhibition constant (Ki) = 61.16 ± 12.96 µM, in addition to the lowest hemolytic activity of the series. Further experiments revealed the antithrombotic activity of this compound in an in vivo model of arterial thrombosis induced by FeCl3.

https://doi.org/10.21577/0103-5053.20180150 940 downloads

12.

Gas exchanges and growth of passion fruit seedlings under salt stress and hydrogen peroxide1
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Silva, André Alisson Rodrigues da

; Lima, Geovani Soares de

; Azevedo, Carlos Alberto Vieira de

; Gheyi, Hans Raj

; Souza, Leandro de Pádua

; Veloso, Luana Lucas de Sá Almeida

Pesquisa Agropecuária Tropical

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2019, Volume 49 elocation e55671

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A região semiárida do Nordeste brasileiro apresenta condições edafoclimáticas adequadas à produção do maracujazeiro, mas a água utilizada na irrigação, comumente, possui altas concentrações de sais, que são prejudiciais ao crescimento e desenvolvimento das plantas. O fornecimento prévio de peróxido de hidrogênio induz a aclimatação das plantas sob condições de estresse salino, reduzindo os efeitos deletérios sobre o seu crescimento e fisiologia. Objetivou-se avaliar as trocas gasosas e o crescimento do maracujazeiro, em função da irrigação com águas salinas e aplicação exógena de peróxido de hidrogênio. O estudo foi conduzido em casa-de-vegetação, utilizando-se delineamento de blocos casualizados, em arranjo fatorial 4 x 4, sendo quatro níveis de condutividade elétrica da água de irrigação (0,7 dS m-1; 1,4 dS m-1; 2,1 dS m-1; e 2,8 dS m-1) e quatro concentrações de peróxido de hidrogênio (0 µM, 25 µM, 50 µM e 75 µM), com quatro repetições e duas plantas por parcela. A aplicação de peróxido de hidrogênio atenuou os efeitos deletérios da salinidade da água de irrigação sobre a transpiração, taxa de assimilação de CO2, concentração interna de carbono, altura de planta e área foliar do maracujazeiro amarelo, aos 60 dias após a semeadura, sendo a concentração de 25 µM a mais eficiente. A irrigação com água de condutividade elétrica acima de 0,7 dS m-1 afeta negativamente as trocas gasosas e o crescimento do maracujazeiro, sendo a condutância estomática e a área foliar as variáveis mais sensíveis ao estresse salino.

ABSTRACT The semi-arid region of the Brazilian Northeast has adequate edaphoclimatic conditions for the passion fruit production, but the water used for irrigation commonly has high concentrations of salts that are harmful to the plant growth and development. A previous supply of hydrogen peroxide induces the acclimation of plants under saline stress conditions, reducing deleterious effects on their growth and physiology. This study aimed to evaluate the gas exchanges and growth of passion fruit as a function of irrigation with saline water and exogenous application of hydrogen peroxide. The experiment was carried out under greenhouse conditions, using a randomized block design, in a 4 x 4 factorial arrangement, being four levels of irrigation water electrical conductivity (0.7 dS m-1, 1.4 dS m-1, 2.1 dS m-1 and 2.8 dS m-1) and four hydrogen peroxide concentrations (0 µM, 25 µM, 50 µM and 75 µM), with four replicates and two plants per plot. The hydrogen peroxide application attenuated the deleterious effects of the irrigation water salinity on transpiration, CO2 assimilation rate, internal carbon concentration, plant height and leaf area of yellow passion fruit, at 60 days after sowing, with the concentration of 25 µM being the most efficient. Irrigation using water with electrical conductivity above 0.7 dS m-1 negatively affects the gas exchanges and growth of passion fruit, being the stomatal conductance and leaf area the most sensitive variables to the salt stress.

https://doi.org/10.1590/1983-40632019v4955671 1151 downloads

13.

Hepatitis C in Brazil: lessons learned with boceprevir and telaprevir
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Gomes, Lenyta Oliveira

; Teixeira, Marina Rodrigues

; Rosa, Júnior André da

; Feltrin, Alberi Adolfo

; Rodrigues, João Paulo V.

; Vecchi, Mariane D’Avila

; Carneiro, Jane Meire M.

; Noblat, Lúcia de Araújo C. B.

; Chachá, Silvana Gama F.

; Martinelli, Ana de Lourdes C.

; Pereira, Leonardo Regis L.

; Silveira, Marysabel Pinto T.

; Blatt, Carine Raquel

; Farias, Mareni Rocha

Revista do Instituto de Medicina Tropical de São Paulo

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2018, Volume 60 elocation e29

Resumo: En | Texto: En | PDF: En

ABSTRACT In 2012, the first-generation protease inhibitors telaprevir (TVR) and boceprevir (BOC) were introduced in the Brazilian health system for treatment of chronic hepatitis C, after their approval by the National Committee for Health Technology Incorporation (CONITEC). However, these medicines were discontinued in 2015. The short period of use in therapy and their high cost require a discussion about the consequences for patients and for the health system of the early incorporation of new therapies. The article presents a qualitative analysis of the incorporation process of both medications in Brazil and the results of a multicenter study that included patients treated with BOC or TVR between January 2011 and December 2015 in five Brazilian cities. The study included 855 patients (BOC: n=247) and (TVR: n=608). The document analysis showed that CONITEC’s decision to incorporate BOC and TVR was based on results of phase III clinical trials that compared sustained virologic response (SVR) rates of patients treated with BOC and TVR with rates of those that received placebo. However, these studies included a low percentage of cirrhotic patients. The SVR rates observed in this multicenter study were worse than clinical trials pointed out (BOC: 45.6%; TVR: 51.8%), but similar to those achieved with previously adopted therapies. The discontinuation rate due to adverse events was (BOC: 15.4%; TVR: 12.7%). Based on these unsatisfactory results, the study brings a discussion that goes beyond the therapy outcomes, exploring the incorporation of these high-cost medicines and the related decision-making process, contributing to future decisions in medicine policies and in the treatment of chronic hepatitis C.

https://doi.org/10.1590/s1678-9946201860029 1586 downloads

14.

3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology
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Gualandro, Danielle Menosi

; Yu, Pai Ching

; Caramelli, Bruno

; Marques, André Coelho

; Calderaro, Daniela

; Fornari, Luciana Savoy

; Pinho, Claudio

; Feitosa, Alina Coutinho Rodrigues

; Polanczyk, Carisi Anne

; Rochitte, Carlos Eduardo

; Jardim, Carlos

; Vieira, Carolina L. Z.

; Nakamura, Debora Y. M.

; Iezzi, Denise

; Schreen, Dirk

; Adam, Eduardo Leal

; D’Amico, Elbio Antonio

; Lima, Emerson Q. de

; Burdmann, Emmanuel de Almeida

; Mateo, Enrique Indalecio Pachón

; Marcondes-Braga, Fabiana Goulart

; Machado, Fabio S.

; Paula, Flavio J. de

; Carmo, Gabriel Assis Lopes do

; Feitosa-Filho, Gilson Soares

; Prado, Gustavo Faibischew

; Lopes, Heno Ferreira

; Fernandes, João R. C.

; Lima, José J. G. de

; Sacilotto, Luciana

; Drager, Luciano Ferreira

; Vacanti, Luciano Janussi

; Rohde, Luis Eduardo Paim

; Prada, Luis F. L.

; Gowdak, Luis Henrique Wolff

; Vieira, Marcelo Luiz Campos

; Monachini, Maristela Camargo

; Macatrão-Costa, Milena Frota

; Paixão, Milena Ribeiro

; Oliveira Junior, Mucio Tavares de

; Cury, Patricia

; Villaça, Paula R.

; Farsky, Pedro Silvio

; Siciliano, Rinaldo F.

; Heinisch, Roberto Henrique

; Souza, Rogerio

; Gualandro, Sandra F.M.

; Accorsi, Tarso Augusto Duenhas

; Mathias Júnior, Wilson

Arquivos Brasileiros de Cardiologia

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Set 2017, Volume 109 Nº 3 Páginas 1 - 104

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/abc.20170140 100302 downloads

15.

Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate
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Eger, Guilherme A.

; Ferreira, Vinícius V.

; Batista, Camila R.

; Bonde, Henrique

; Lima, Daniela D. de

; Wyse, Angela T.S.

; Cruz, Júlia N. da

; Rodrigues, André F.

; Magro, Débora D. Dal

; Cruz, José G.P. da

Anais da Academia Brasileira de Ciências

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Mar 2016, Volume 88 Nº 1 Páginas 335 - 348

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

O presente estudo tem o objetivo de investigar diretamente os efeitos comportamentais e antioxidantes da sinvastatina em um modelo de mania bipolar induzida por dimesilato de lisdexanfetamina. Ratos Wistar foram tratados durante 30 dias com simvastatina. No 24º dia após o início do tratamento, foi administrada dimesilato de lisdexanfetamina durante 7 dias em cada rato. Os resultados sugerem que sinvastatina combinada com dimesilato de lisdexanfetamina induziu um aumento significativo na locomoção, e administração de dimesilato de lisdexanfetamina provoca um desequilíbrio oxidativo determinado por um aumento na peroxidação lipídica, oxidação de proteínas e alterações nas atividades de enzimas antioxidantes em áreas do cérebro; adicionalmente, na presença de sinvastatina a maioria destes efeitos foram bloqueados. Estes resultados contribuem para um melhor entendimento dos papeis críticos do tratamento dos distúrbios neuropsiquiátricos com dimesilato de lisdexanfetamina, associado com o aumento do estresse oxidativo e com alterações das enzimas antioxidantes. Tendo em vista o papel central exercido pelo dimesilato de lisdexanfetamina, o efeito antioxidante estabelecido pela terapia com sinvastatina é de grande interesse.

The present study aims to directly investigate the behavioral and antioxidant effects of simvastatin in a model of bipolar mania induced by lisdexamfetamine dimesylate. Wistar rats were treated for 30 days with simvastatin. On the 24th day after the start of treatment, each rat was administered lisdexamfetamine dimesylate for 7 days. The results suggest that simvastatin combined with lisdexamfetamine dimesylate induced a significant increased locomotion and lisdexamfetamine dimesylate administration causes an oxidative imbalance determined by an increment in lipid peroxidation, protein oxidation and alterations in the activities of antioxidant enzymes in brain areas; moreover, in the presence of simvastatin, most of these effects were prevented. These findings contribute to a better understanding of the critical roles of lisdexamfetamine dimesylate in the treatment of neuropsychiatric disorders, associated with increased oxidative stress and changes in antioxidant enzymatic defense. In view of the central role played by lisdexamfetamine dimesylate, the established antioxidant effect of simvastatin therapy is of major interest.

https://doi.org/10.1590/0001-3765201620140490 2552 downloads

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