Abstract Objective: To assess the epidemiological profile and trend in hospitalizations for mental and behavioral disorders due to alcohol and other psychoactive substance use among Brazilian adolescents, between 2017 and 2022. Methods: This was a time-series study using data from the Hospital Information System of the Brazilian National Health System; the trend analysis was performed by estimating the annual percentage change (APC) of hospitalization rates per 100,000 inhabitants and respective confidence intervals (95%CI), using the Prais-Winsten method. Results: A total of 29,991 hospitalizations were recorded in the study period, with a decreasing trend observed, from 16.18/100,000 inhabitants in 2017 to 13.72/100,000 inhab. in 2022 (percent change of -2.65%; 95%CI -4.47;-0.80), a greater decline was found in males (-3.48%; 95%CI -5.20;-1.72), in the age group of 15 to 19 years (-2.79%; 95%CI -4.49;-1.06), in the South (-3.29%; 95%CI -5.37;-1.16) and Midwest (-3.64%; 95%CI -5.75;-1.49) regions of the country. Conclusion: Hospitalizations showed a decreasing trend in the study period, with sociodemographic disparities. Objective adolescents 201 Methods timeseries time series APC (APC 100000 100 000 100,00 95%CI, 95CI CI , 95 (95%CI) PraisWinsten Prais Winsten method Results 29991 29 991 29,99 period observed 1618100000 16 18 16.18/100,00 1372100000 13 72 13.72/100,00 inhab 202 percent 2.65% 265 2 65 -2.65% 4.470.80, 447080 4.47 0.80 4 47 0 80 -4.47;-0.80) 3.48% 348 3 48 (-3.48% 5.201.72, 520172 5.20 1.72 5 20 1 -5.20;-1.72) 2.79% 279 79 (-2.79% 4.491.06, 449106 4.49 1.06 49 06 -4.49;-1.06) 3.29% 329 (-3.29% 5.371.16 537116 5.37 1.16 37 -5.37;-1.16 3.64% 364 64 (-3.64% 5.751.49 575149 5.75 1.49 75 -5.75;-1.49 country Conclusion disparities 10000 10 00 100,0 9 (95%CI 2999 99 29,9 161810000 16.18/100,0 137210000 7 13.72/100,0 2.65 26 6 -2.65 470 4.470.80 44708 447 4.4 080 0.8 8 -4.47;-0.80 3.48 34 (-3.48 5.201.72 52017 520 5.2 172 1.7 -5.20;-1.72 2.79 27 (-2.79 491 4.491.06 44910 449 106 1.0 -4.49;-1.06 3.29 32 (-3.29 371 5.371.1 53711 537 5.3 116 1.1 -5.37;-1.1 3.64 36 (-3.64 751 5.751.4 57514 575 5.7 149 1.4 -5.75;-1.4 1000 100, 299 29, 16181000 16.18/100, 13721000 13.72/100, 2.6 -2.6 4.470.8 4470 44 4. 08 0. -4.47;-0.8 3.4 (-3.4 5.201.7 5201 52 5. 17 1. -5.20;-1.7 2.7 (-2.7 4.491.0 4491 -4.49;-1.0 3.2 (-3.2 5.371. 5371 53 11 -5.37;-1. 3.6 (-3.6 5.751. 5751 57 14 -5.75;-1. 1618100 16.18/100 1372100 13.72/100 2. -2. 4.470. -4.47;-0. 3. (-3. 5.201. -5.20;-1. (-2. 4.491. -4.49;-1. 5.371 -5.37;-1 5.751 -5.75;-1 161810 16.18/10 137210 13.72/10 -2 4.470 -4.47;-0 (-3 5.201 -5.20;-1 (-2 4.491 -4.49;-1 -5.37;- -5.75;- 16181 16.18/1 13721 13.72/1 - -4.47;- (- -5.20;- -4.49;- -5.37; -5.75; 1618 16.18/ 1372 13.72/ -4.47; ( -5.20; -4.49; -5.37 -5.75 161 16.18 137 13.72 -4.47 -5.20 -4.49 -5.3 -5.7 16.1 13.7 -4.4 -5.2 -5. 16. 13. -4. -5 -4

Resumen Objetivo: Analizar el perfil epidemiológico y la tendencia de las hospitalizaciones por trastornos mentales y de comportamiento relacionados con el uso de alcohol y otras sustancias psicoactivas en adolescentes brasileños, desde 2017 hasta 2022. Métodos: Estudio de serie temporal utilizando el Sistema de Información Hospitalaria del Sistema Único de Salud; se evaluó la tendencia mediante la estimación del cambio porcentual anual (CPA) de las tasas de hospitalización por cada 100,000 habitantes y sus respectivos intervalos mediante el método de Prais-Winsten. Resultados: Se registraron 29.991 hospitalizaciones durante el período y se observó una tendencia decreciente en Brasil, desde 16,18 hospitalizaciones por cada 100.000 habitantes en 2017 hasta 13,72 en 2022 (variación de -2,65%; IC₉₅% -4,47;-0,80), con mayor declive en hombres (-3,48%; IC₉₅% -5,20;-1,72), en la edad de 15 a 19 años (-2,79%; IC₉₅% -4,49;-1,06), en las regiones del Sur (-3,29%; IC₉₅% -5,37; -1,16) y Centro-Oeste (-3,64%; IC₉₅% -5,75;-1,49). Conclusión: Las hospitalizaciones mostraron una tendencia decreciente en el período, con disparidades sociodemográficas. Objetivo brasileños 201 Métodos Salud CPA (CPA 100000 100 000 100,00 PraisWinsten. PraisWinsten Prais Winsten. Winsten Prais-Winsten Resultados 29991 29 991 29.99 Brasil 1618 16 18 16,1 100.00 1372 13 72 13,7 202 variación 2,65% 265 2 65 -2,65% IC₉₅ IC 4,470,80, 447080 4,47 0,80 , 4 47 0 80 -4,47;-0,80) 3,48% 348 3 48 (-3,48% 5,201,72, 520172 5,20 1,72 5 20 1 -5,20;-1,72) 2,79% 279 79 (-2,79% 4,491,06, 449106 4,49 1,06 49 06 -4,49;-1,06) 3,29% 329 (-3,29% 5,37 537 37 -5,37 1,16 116 -1,16 CentroOeste Centro Oeste 3,64% 364 64 (-3,64% 5,751,49. 575149 5,75 1,49 . 75 -5,75;-1,49) Conclusión sociodemográficas 10000 10 00 100,0 2999 99 29.9 161 16, 100.0 137 7 13, 2,65 26 6 -2,65 IC₉ 470 4,470,80 44708 447 4,4 080 0,8 8 -4,47;-0,80 3,48 34 (-3,48 5,201,72 52017 520 5,2 172 1,7 -5,20;-1,72 2,79 27 (-2,79 491 4,491,06 44910 449 106 1,0 -4,49;-1,06 3,29 32 (-3,29 5,3 53 -5,3 1,1 11 -1,1 3,64 36 (-3,64 751 5,751,49 57514 575 5,7 149 1,4 -5,75;-1,49 1000 100, 299 9 29. 100. 2,6 -2,6 4,470,8 4470 44 4, 08 0, -4,47;-0,8 3,4 (-3,4 5,201,7 5201 52 5, 17 1, -5,20;-1,7 2,7 (-2,7 4,491,0 4491 -4,49;-1,0 3,2 (-3,2 -5, -1, 3,6 (-3,6 5,751,4 5751 57 14 -5,75;-1,4 2, -2, 4,470, -4,47;-0, 3, (-3, 5,201, -5,20;-1, (-2, 4,491, -4,49;-1, -5 -1 5,751, -5,75;-1, -2 4,470 -4,47;-0 (-3 5,201 -5,20;-1 (-2 4,491 -4,49;-1 - 5,751 -5,75;-1 -4,47;- (- -5,20;- -4,49;- -5,75;- -4,47; ( -5,20; -4,49; -5,75; -4,47 -5,20 -4,49 -5,75 -4,4 -5,2 -5,7 -4, -4

Resumo Objetivo: Analisar o perfil epidemiológico e a tendência das internações hospitalares por transtornos mentais e comportamentais devido ao uso de álcool e de outras substâncias psicoativas em adolescentes brasileiros, de 2017 a 2022. Métodos: Estudo de série temporal com dados do Sistema de Informações Hospitalares do Sistema Único de Saúde. A tendência foi analisada estimando-se a variação percentual anual (VPA) das taxas de internação por 100 mil habitantes e respectivos Intervalos pelo método de Prais-Winsten. Resultados: Foram registradas 29.991 internações no período, sendo observada uma tendência decrescente das internações no Brasil, variando de 16,18 internações por 100 mil hab., em 2017, para 13,72 em 2022 (variação de -2,65%; IC₉₅% -4,47; -0,80), com maior declínio no sexo masculino (-3,48%; IC₉₅% -5,20;-1,72), na faixa etária de 15 a 19 anos (-2,79%; IC₉₅% -4,49;-1,06), nas regiões Sul (-3,29%; IC₉₅% -5,37;-1,16) e Centro-Oeste (-3,64%; IC₉₅% -5,75;-1,49). Conclusão: As internações apresentaram tendência decrescente no período, com disparidades sociodemográficas. Objetivo brasileiros 201 Métodos Saúde estimandose estimando se VPA (VPA 10 PraisWinsten. PraisWinsten Prais Winsten. Winsten Prais-Winsten Resultados 29991 29 991 29.99 período Brasil 1618 16 18 16,1 hab hab. 1372 13 72 13,7 202 2,65% 265 2 65 -2,65% IC₉₅ IC 4,47 447 4 47 -4,47 0,80, 080 0,80 , 0 80 -0,80) 3,48% 348 3 48 (-3,48% 5,201,72, 520172 5,20 1,72 5 20 1 -5,20;-1,72) 2,79% 279 79 (-2,79% 4,491,06, 449106 4,49 1,06 49 06 -4,49;-1,06) 3,29% 329 (-3,29% 5,371,16 537116 5,37 1,16 37 -5,37;-1,16 CentroOeste Centro Oeste 3,64% 364 64 (-3,64% 5,751,49. 575149 5,75 1,49 . 75 -5,75;-1,49) Conclusão sociodemográficas 2999 99 29.9 161 16, 137 7 13, 2,65 26 6 -2,65 IC₉ 4,4 44 -4,4 08 0,8 8 -0,80 3,48 34 (-3,48 5,201,72 52017 520 5,2 172 1,7 -5,20;-1,72 2,79 27 (-2,79 491 4,491,06 44910 449 106 1,0 -4,49;-1,06 3,29 32 (-3,29 371 5,371,1 53711 537 5,3 116 1,1 -5,37;-1,1 3,64 36 (-3,64 751 5,751,49 57514 575 5,7 149 1,4 -5,75;-1,49 299 9 29. 2,6 -2,6 4, -4, 0, -0,8 3,4 (-3,4 5,201,7 5201 52 5, 17 1, -5,20;-1,7 2,7 (-2,7 4,491,0 4491 -4,49;-1,0 3,2 (-3,2 5,371, 5371 53 11 -5,37;-1, 3,6 (-3,6 5,751,4 5751 57 14 -5,75;-1,4 2, -2, -4 -0, 3, (-3, 5,201, -5,20;-1, (-2, 4,491, -4,49;-1, 5,371 -5,37;-1 5,751, -5,75;-1, -2 - -0 (-3 5,201 -5,20;-1 (-2 4,491 -4,49;-1 -5,37;- 5,751 -5,75;-1 (- -5,20;- -4,49;- -5,37; -5,75;- ( -5,20; -4,49; -5,37 -5,75; -5,20 -4,49 -5,3 -5,75 -5,2 -5, -5,7 -5

Resumen Objetivo: Analizar el perfil epidemiológico y la tendencia de las hospitalizaciones por trastornos mentales y de comportamiento relacionados con el uso de alcohol y otras sustancias psicoactivas en adolescentes brasileños, desde 2017 hasta 2022. Métodos: Estudio de serie temporal utilizando el Sistema de Información Hospitalaria del Sistema Único de Salud; se evaluó la tendencia mediante la estimación del cambio porcentual anual (CPA) de las tasas de hospitalización por cada 100,000 habitantes y sus respectivos intervalos mediante el método de Prais-Winsten. Resultados: Se registraron 29.991 hospitalizaciones durante el período y se observó una tendencia decreciente en Brasil, desde 16,18 hospitalizaciones por cada 100.000 habitantes en 2017 hasta 13,72 en 2022 (variación de -2,65%; IC₉₅% -4,47;-0,80), con mayor declive en hombres (-3,48%; IC₉₅% -5,20;-1,72), en la edad de 15 a 19 años (-2,79%; IC₉₅% -4,49;-1,06), en las regiones del Sur (-3,29%; IC₉₅% -5,37; -1,16) y Centro-Oeste (-3,64%; IC₉₅% -5,75;-1,49). Conclusión: Las hospitalizaciones mostraron una tendencia decreciente en el período, con disparidades sociodemográficas.

Abstract Objective: To assess the epidemiological profile and trend in hospitalizations for mental and behavioral disorders due to alcohol and other psychoactive substance use among Brazilian adolescents, between 2017 and 2022. Methods: This was a time-series study using data from the Hospital Information System of the Brazilian National Health System; the trend analysis was performed by estimating the annual percentage change (APC) of hospitalization rates per 100,000 inhabitants and respective confidence intervals (95%CI), using the Prais-Winsten method. Results: A total of 29,991 hospitalizations were recorded in the study period, with a decreasing trend observed, from 16.18/100,000 inhabitants in 2017 to 13.72/100,000 inhab. in 2022 (percent change of -2.65%; 95%CI -4.47;-0.80), a greater decline was found in males (-3.48%; 95%CI -5.20;-1.72), in the age group of 15 to 19 years (-2.79%; 95%CI -4.49;-1.06), in the South (-3.29%; 95%CI -5.37;-1.16) and Midwest (-3.64%; 95%CI -5.75;-1.49) regions of the country. Conclusion: Hospitalizations showed a decreasing trend in the study period, with sociodemographic disparities.

Resumo Objetivo: Analisar o perfil epidemiológico e a tendência das internações hospitalares por transtornos mentais e comportamentais devido ao uso de álcool e de outras substâncias psicoativas em adolescentes brasileiros, de 2017 a 2022. Métodos: Estudo de série temporal com dados do Sistema de Informações Hospitalares do Sistema Único de Saúde. A tendência foi analisada estimando-se a variação percentual anual (VPA) das taxas de internação por 100 mil habitantes e respectivos Intervalos pelo método de Prais-Winsten. Resultados: Foram registradas 29.991 internações no período, sendo observada uma tendência decrescente das internações no Brasil, variando de 16,18 internações por 100 mil hab., em 2017, para 13,72 em 2022 (variação de -2,65%; IC₉₅% -4,47; -0,80), com maior declínio no sexo masculino (-3,48%; IC₉₅% -5,20;-1,72), na faixa etária de 15 a 19 anos (-2,79%; IC₉₅% -4,49;-1,06), nas regiões Sul (-3,29%; IC₉₅% -5,37;-1,16) e Centro-Oeste (-3,64%; IC₉₅% -5,75;-1,49). Conclusão: As internações apresentaram tendência decrescente no período, com disparidades sociodemográficas.

RESUMEN: Las proteínas S100 pertenecen al grupo de proteínas fijadoras de calcio y están presentes en actividades reguladoras fisiológicas intracelulares y extracelulares, como la diferenciación celular, y actúan en procesos patológicos inflamatorios y neoplásicos. Recientemente, sus expresiones en el sistema nervioso han sido ampliamente estudiadas, buscando dilucidar su acción a nivel del tálamo: una estructura del sistema nervioso central que forma parte de importantes circuitos, como el somatosensorial, conductual, de memoria y cognitivo, así como además de ser responsable de la transmisión y regulación de la información a la corteza cerebral. Este artículo es una revisión integradora de la literatura científica, que analizó 12 estudios presentes en Pubmed. El análisis mostró que la relación de las proteínas S100 y el tálamo ha sido descrita en procesos neoplásicos, trastornos mentales, hipoxia, trauma, estrés, infección, enfermedad de Parkinson y epilepsia. En resumen, es posible concluir que esta familia de proteínas es relevante como marcador en procesos de lesión talámica, requiriendo más estudios para comprender mejor su significado clínico, preclínico y su valor pronóstico.

SUMMARY: S100 proteins belong group of calcium-binding proteins and are present in physiological intracellular and extracellular regulatory activities, such as cell differentiation, and act in inflammatory and neoplastic pathological processes. Recently, its expressions in the nervous system have been extensively studied, seeking to elucidate its action at the level of the thalamus: A structure of the central nervous system that is part of important circuits, such as somatosensory, behavioral, memory and cognitive, as well as being responsible for the transmission and regulation of information to the cerebral cortex. This article is an integrative review of scientific literature, which analyzed 12 studies present in Pubmed. The analysis showed that the relationship of S100 proteins and the thalamus has been described in neoplastic processes, mental disorders, hypoxia, trauma, stress, infection, Parkinson's disease and epilepsy. In summary, it is possible to conclude that this protein family is relevant as a marker in processes of thalamic injury, requiring further studies to better understand its clinical, preclinical meanings and its prognostic value.

ABSTRACT Reconstructive surgery with endoprostheses is the chosen method for treating bone malignancies. Postoperative infections are frequent complications, and their treatment involves prolonged hospital stays and antibiotic therapy. Among the advancements aimed at reducing the rate of postoperative infection, the use of incisional negative pressure therapy (iNPT) has shown promising results, with no reports in the literature regarding its use in patients with such conditions. Objective: To evaluate the effectiveness of iNPT in reducing postoperative complications in surgeries for resection of bone tumors associated with modular endoprosthesis reconstruction. Methods: Retrospective case series of 16 patients diagnosed with osteosarcoma, who underwent resection and reconstruction with endoprosthesis associated with iNPT during the postoperative period. Follow-up was performed for a period of six months, and the evaluated outcomes were the incidence of postoperative infection and complications of the surgical wound. Results: The use of iNPT for a postoperative period of seven days resulted in only three (18.7%) cases of postoperative infection. No cases of wound dehiscence, seroma formation, or hematoma at the surgical site were observed. Conclusion: The rate of surgical wound complications in our case series is lower than that reported in most of the literature, and iNPT appears to be an efficient way to reduce the rate of local complications in reconstructive surgeries with endoprosthesis after resection of bone malignancies. Level of Evidence III, Retrospective Study. malignancies (iNPT results conditions Objective Methods 1 osteosarcoma Followup Follow up months Results 18.7% 187 18 7 (18.7% dehiscence formation observed Conclusion III Study 18.7 (18.7 18. (18. (18 (1 (

RESUMO A cirurgia reconstrutiva com endopróteses é o método escolhido no tratamento de malignidades ósseas. As infecções pós-operatórias são complicações frequentes, e seu tratamento envolve internações e antibioticoterapia prolongadas. Entre os avanços que visam reduzir a taxa de infecção pós-operatória, o uso da terapia com pressão negativa incisional (TPNi) vem mostrando resultados promissores, não havendo relatos na literatura de seu emprego em pacientes com tal quadro. Objetivo: Avaliar a eficácia da TPNi em reduzir complicações pós-operatórias em cirurgias de ressecção de tumores ósseos associadas à reconstrução com endopróteses modulares. Métodos: Série de casos retrospectiva de 16 pacientes diagnosticados com osteossarcoma, submetidos à ressecção e reconstrução com endoprótese associada à TPNi durante o pós-operatório. Foi realizado seguimento por um período de seis meses e os desfechos avaliados foram incidência de infecção pós-operatória e complicações da ferida operatória. Resultados: O uso da TPNi por um período pós-operatório de sete dias resultou em apenas três (18,7%) casos de infecção pós-operatória. Não foram observados casos em que ocorreu deiscência da ferida operatória, formação de seromas ou hematomas no sítio cirúrgico. Conclusão: A taxa de complicações de ferida operatória em nossa série de casos é menor que a da maior parte da literatura, e a TPNi parece ser uma forma eficiente de reduzir a taxa de complicações locais em cirurgias reconstrutivas com endoprótese após ressecção de malignidades ósseas. Nível de Evidência III, Estudo Retrospectivo. ósseas pósoperatórias pós operatórias frequentes prolongadas pósoperatória, pósoperatória (TPNi promissores quadro Objetivo modulares Métodos 1 osteossarcoma pósoperatório. pósoperatório operatório. operatório Resultados 18,7% 187 18 7 (18,7% pósoperatória. cirúrgico Conclusão III Retrospectivo 18,7 (18,7 18, (18, (18 (1 (

SUMMARY OBJECTIVE: This study aimed to validate the internal structure of the Brazilian version of the Baecke Habitual Physical Activity Questionnaire. METHODS: A cross-sectional study was conducted with individuals over 18 years old of both sexes, with Brazilian Portuguese as their native language. The structure of the Baecke Habitual Physical Activity Questionnaire was tested by confirmatory factor analysis. The model fit was evaluated by the following indices: root mean square error of approximation, comparative fit index, Tucker-Lewis index, standardized root mean square residual, and χ²/degrees of freedom. We used the Akaike information criterion and Bayesian information criterion to compare different structures of the Baecke Habitual Physical Activity Questionnaire. RESULTS: A total of 241 individuals participated in this study. The original structure of the Baecke Habitual Physical Activity Questionnaire with 16 items and 3 domains was compared to a structure with 14 items and 3 domains. The internal structure of the Baecke Habitual Physical Activity Questionnaire with 14 items showed better fit indices and lower Akaike information criterion and Bayesian information criterion values. CONCLUSION: The best internal structure of the Brazilian version of the Baecke Habitual Physical Activity Questionnaire in adults presents 3 domains and 14 items.

Abstract: Cold-formed Steel profiles are structural profiles widely used in civil construction. They are often manufactured with perforations. The designing can be performed using the direct resistance method. Formulations were adapted by (Moen and Schafer, 2008) to consider the presence of perforations in these profiles. The objective of this study is to investigate the structural safety of columns with web perforations. The calculation of the resistance capacity was performed using the formulations proposed by the authors. The reliability indexes were determined using the First Order Reliability Method (FORM), First Order Second Moment (FOSM) and Monte Carlo Method (MCM), which are reliability methods for the Load and Resistance Factor Design (LRFD) and Limit States Design (LSD) philosophies. Following the same criteria performed by AISI S100, the resistance factors were obtained from the FOSM method. Based on the results, it was found that the desired security level for the LSD philosophy was not achieved. The calculated resistance factors are predominantly lower than the target. However, for the LRFD philosophy, the safety level was achieved, and the resistance factors were higher than the target.

Resumen: Los perfiles de acero conformados en frío son perfiles estructurales muy utilizados en la construcción civil, comúnmente fabricados con perforaciones. El diseño se puede realizar utilizando el método de resistencia directa. Las formulaciones fueron adaptadas por (Moen y Schafer, 2008), las cuales consideran la presencia de perforaciones. El objetivo de este estudio es investigar la seguridad estructural de columnas con perforaciones en el alma. El cálculo de la capacidad de resistencia se realizó utilizando las formulaciones propuestas por los autores mencionados. Los índices de confiabilidad se determinaron utilizando el Método de Confiabilidad de Primer Orden (FORM), de Primer Orden Segundo Momento (FOSM) y el Método de Montecarlo, que son métodos de confiabilidad para los Factores de Carga y de Resistencia (LRFD) y Estados Límite (LSD). Siguiendo los mismos criterios realizados por el AISI S100, los factores de resistencia se obtuvieron del método FOSM. Con base en los resultados, se encontró que no se logró el nivel de seguridad deseado para la filosofía LSD. Los factores de resistencia calculados son predominantemente más bajos que el objetivo. Sin embargo, para la filosofía LRFD, se logró el nivel de seguridad y los factores de resistencia fueron más altos que el objetivo.

Abstract Objective: To provide guidelines on the coronavirus disease 2019 (COVID-19) vaccination in patients with immune-mediated rheumatic diseases (IMRD) to rheumatologists considering specific scenarios of the daily practice based on the shared-making decision (SMD) process. Methods: A task force was constituted by 24 rheumatologists (panel members), with clinical and research expertise in immunizations and infectious diseases in immunocompromised patients, endorsed by the Brazilian Society of Rheumatology (BSR), to develop guidelines for COVID-19 vaccination in patients with IMRD. A consensus was built through the Delphi method and involved four rounds of anonymous voting, where five options were used to determine the level of agreement (LOA), based on the Likert Scale: (1) strongly disagree; (2) disagree, (3) neither agree nor disagree (neutral); (4) agree; and (5) strongly agree. Nineteen questions were addressed and discussed via teleconference to formulate the answers. In order to identify the relevant data on COVID-19 vaccines, a search with standardized descriptors and synonyms was performed on September 10th, 2021, of the MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and LILACS to identify studies of interest. We used the Newcastle–Ottawa Scale to assess the quality of nonrandomized studies. Results: All the nineteen questions-answers (Q&A) were approved by the BSR Task Force with more than 80% of panelists voting options 4—agree—and 5—strongly agree—, and a consensus was reached. These Guidelines were focused in SMD on the most appropriate timing for IMRD patients to get vaccinated to reach the adequate covid-19 vaccination response. Conclusion: These guidelines were developed by a BSR Task Force with a high LOA among panelists, based on the literature review of published studies and expert opinion for COVID-19 vaccination in IMRD patients. Noteworthy, in the pandemic period, up to the time of the review and the consensus process for this document, high-quality evidence was scarce. Thus, it is not a substitute for clinical judgment.

Abstract Evaluate of cashew nut shell liquid (alginate-CNSL) on TBARS, physicochemical attributes and microbial growing of beef steak was investigated. Three edible coating treatments were prepared: (1) control (uncoating); (2) sodium alginate coating (no additive); and (3) active coatings of sodium alginate added cashew nut shell liquid (alginate-CNSL) at 1% into. Color indexes and water holding capacity were not affected by coating treatments. The pH of the beef samples from the control treatment increased at storage time, and the beef involved with alginate-CNSL coating maintained a pH stable. Alginate-CNSL coating promoted cooking loss lower after 3rd day of storage. Alginate-CNSL coating promoted a lower shear force decrease compared at control and sodium alginate coating. Alginate-CNSL coating reduced lipid oxidation (TBARS) and microbial growing (mesophiles and psychrophiles counts) in beef compared others treatments. Active coating from CNSL (1%) improved the beef preservation, reducing lipid oxidation and microbial growing, until the 6th day of storage stability.

Abstract This article presents a procedure for the reliability assessment of cold-formed steel beams based on the Direct Strength Method (DSM) and the Effective Section Method (ESM). Using a comprehensive database, a statistical analysis of the test results was performed to determine the statistical properties of the professional factor random variable. The statistical parameters related to material strength, geometric properties and load effects were obtained from established references for reliability analysis. Safety levels compatible with the North American and the Brazilian codes relating to structural design of cold-formed steel members have been established. The first-order reliability method (FORM) was used to calculate resistance factors φ for usual nominal live-dead ratios. The results of the reliability analysis showed that the DSM and ESM design methods have similar levels of reliability. The same resistance factor as the DSM can be used for the ESM, without compromising the minimum level of reliability established. The results obtained with the LRFD calibration data, presented a good approximation with the load factor φ = 0.90, except for the distortional mode. With the LSD calibration data, values well below the specified were required in order to achieve the required level of reliability. It was also found that the load factor γ = 1.25, in the format of the Brazilian standard, could reach the safety requirements established for all buckling modes.

ABSTRACT The main objective of this study was to evaluate the effect of placement time on the performance of broiler chickens and the development of their gastrointestinal tract. Two methodologies for measuring broiler performance were compared, one considering day of pulling as the first day, the other considering day of placement as the first day. A total of 1,056 one-day old male Cobb® 500 broiler chicks were subjected to treatments of different placement times after pulling from the hatchery: 3, 24, 48, and 72 h. The studied traits were: feed intake, body weight, feed conversion, viability, and gastrointestinal tract development. When day of pulling was considered the first day, feed intake and body weight at 39 days decreased as placement time increased. However, when day of placement was considered the first day, fasting up to 72 h did not have any negative effect on broiler performance at 39 days post-placement. Placement time did not affect yolk sac utilization or liver weight. At nine days post-placement, weights of gizzard + proventriculus, pancreas, and small intestine increased with increasing placement time. At seven days of age, there was no effect of placement time on villus height or crypt depth. It is possible to place broiler chicks up to 72 h post-hatching with no negative effects when day of placement is considered the first day for evaluating broiler performance.

ABSTRACT Introduction: Hemophilia is well known in males, but poorly recognized in hemophilia carriers, who may have a hemorrhagic tendency, and the symptoms may be frequent and severe. Few studies have been done evidencing this bleeding in female carriers of the hemophilia gene. Objectives: To verify the prevalence of hemorrhagic symptoms in HC, compared to women in the general population. Material and method: The articles published between October 1996 and November 2016 were searched in the PubMed, Scielo, Lilacs, Web of Science, Scopus and Cochrane Central databases. Results and discussion: Seventy-five articles were found in electronic databases and 2 additional articles, through manual search in journal summaries and bibliographical references of other review articles. There is a limitation as to the number of studies that explore the association between the risk of hemorrhagic events and HC A or B. Among the few existing studies, there is a methodological difference, evidenced by control groups with distinct recruitments, divergent questionnaires and non-standardized concepts. Conclusion: This review verified the existence of a higher prevalence of hemorrhagic symptoms in the HC in some outcomes, however, due to the limitations of the few studies found, there is still insufficient evidence to state that the HC has a greater hemorrhagic tendency in relation to the general population.

An experimental study with an A356-AlSiMgFe alloy was developed to evaluate the microhardness performance in the microstructure resulting of an unsteady-state horizontal solidification process. The Al-7wt%Si-0.3wt%Mg-0.15wt%Fe alloy was elaborated and directionally solidified in a water-cooled horizontal solidification device. In order to experimentally determine the cooling and growth rates (VL and TR, respectively), a thermal analysis was also conducted during solidification. Microstructural characterization by optical microscopy, SEM/EDS elemental mapping and microanalysis of the punctual EDS compositions allowed to observe the presence of an Al-rich dendritic phase (Al(α)) with interdendritic phases second composed of an eutectic mixture: Al(α-eutectic) + Si + Al8Mg3FeSi6(π) + Mg2Si(θ). Furthermore, the dendritic microstructure was characterized by measuring the secondary dendritic spacings (λ2) along the horizontally solidified ingot. Higher HV values were observed within the eutectic mixture.

Abstract This article shows a study of the level of reliability of welded and bolted connections in cold formed steel members, for some limiting states, adopted by AISI and Brazilian codes. The aim of this study is the assessment of the reliability index β for a variation of the nominal live-to-dead load ratios as well as comparison of the value found considering different load combinations. The first order reliability method is used to calculate the reliability index β. In this study, reliability indices smaller than 3.5 were obtained, especially for bolted connections. Consideration of the model errors and FORM method, lead to significant reductions in reliability indices, which are found to be less than the recommended target reliability levels.

Ti-6Al-4V alloy is employed in implants because of its good mechanical strength, excellent biocompatibility, and good resistance to corrosion in biological environments. Herein, a composite (HAp-TiO2, 50% by volume of both components) coating surface employing Ti-6Al-4V was characterized. Samples were analyzed post fabrication and post heat treatment to analyze the coating recrystallization, phases, crystallinity, porosity, and roughness. The coating showed rutile crystalline and amorphous Hap phases with crystallinity, porosity, and roughness of 55.6%, 13.6 ± 1.0%, and 4.2 ± 0.6 µm; whereas, after heat treatment, it showed a rutile hydroxyapatite phase and β-TCP with values 75.6%, 13.9 ± 1.9%, and 3.8 ± 0.2 µm, respectively. The composite exhibited 874 ± 26 HV100 hardness and 30 ± 2 MPa adhesion strength after heat treatment, which agree with previously reported data on other bioactive coatings. Therefore, this composite becomes much more crystalline after heating at 750 °C for 1 h.

Aluminum alloys of the ANSI series 319 present Si and Cu as the main alloying elements and the mechanical strength of these alloys can be improved by the precipitation of the metastable Al2Cu phase during the ageing heat treatment. In this paper, the Al-5.5wt.%Si-3wt.%Cu alloy was elaborated and solidified in a water-cooled horizontal directional solidification device. The as-cast ingot was subjected to the precipitation hardening heat treatment (T6 heat treatment), which consisted of: solution for 5 h at 490°C±2°C, followed by quenching in water at 60°C±2°C and ageing for 3 h at 155°C±2°C, and cooling-air. Secondary dendrite arm spacing (λ2) measurements were carried out before and after T6 heat treatment. The mechanical strength of the alloy was investigated by the microhardness test. It has been found that the heat treatment did not influence the λ2 values, however, highest HV values have been observed for the heat-treated samples.