Abstract Forest fragmentation in the Cerrado biome exposes the tree species Myracrodruon urundeuva to the risk of extinction. Thus, the objective of the study was to evaluate silvicultural characteristics related to wood quality, based on genetic parameters estimated in two M. urundeuva progenies from natural populations, assessed in Bauru-SP (PBAU) and Selvíria-MS (PSEL), 31 years after planting. The genetic parameters were estimated according to the REML/BLUP (Restricted maximum likelihood/Best Linear Unbiased Prediction) method using a mixed linear model. The progeny tests detected genetic variation. In PSEL, more positive genetic correlations and a greater number of clusters were observed. Based on the heartwood/sapwood ratio, a higher genetic gain was predicted for PBAU, and for the basic wood density, the genetic gain of the populations was approximately the same. Consequently, the areas of the two progeny tests may be used as future seed orchards to ensure wood quality and long-term ex situ conservation.

Resumo A forma genética da doença de Creutzfeldt-Jakob (gDCJ) representa aproximadamente 15% dos casos de DCJ e o quadro clínico pode ser indistinguível do observado na forma esporádica (eDCJ) ou pode ser atípico, geralmente com início precoce e maior sobrevida. Relatamos o caso de paciente do sexo masculino, 59 anos, que apresentou declínio cognitivo rapidamente progressivo associado a ataxia cerebelar. EEG revelou atividade periódica. DCJ havia sido diagnosticada no irmão e prima do paciente. A avaliação genética evidenciou mutação de ponto no códon 200 (E200K). Óbito ocorreu 11 meses após o início dos sintomas. Não foi realizada autópsia. O quadro clínico da gDCJ associada a E200K é semelhante ao da eDCJ, sendo esta a mutação mais freqüente no gene da proteína prion (PRNP). Este é o primeiro relato da mutação E200K no Brasil, e é possível que a pesquisa rotineira de mutações no PRNP possa identificar maior freqüência desta mutação em nosso meio.

Abstract Genetic Creutzfeldt-Jakob disease (gCJD) represents less than 15% of CJD cases, and its clinical picture may be either indistinguishable from that of sporadic CJD (sCJD) or be atypical, usually with younger onset and longer duration. We report a case of 59-year old Brazilian man who presented rapidly progressive cognitive decline and cerebellar ataxia. EEG revealed periodic activity. A brother and a cousin of the patient had CJD. A point mutation at codon 200 (E200K) of the prion protein gene (PRNP) was found and death occurred 11 months after onset of symptoms. Autopsy was not performed. The clinical presentation of gCJD associated with E200K, which is the most frequent PRNP mutation, is quite similar to sCDJ. This is the first report of E200K mutation in Brazil, and it is possible that a more systematic search for its occurrence may show it to be relatively frequent in Brazil.

Estudo clínico e laboratorial de dois casos de meningorradiculomielopatia esquistossomótica. Considerações são feitas sobre a fisiopatologia e manifestações neurológicas desta parasitose. A positividade das reações imunológicas para Schistosoma mansoni no líquido cefalorraqueano e as melhoras obtidas mediante terapêutica adequada foram valorizadas para o diagnóstico.

The clinical and laboratory findings in two cases of shistosomal meningoradiculomyelopathy due to Schistosoma mansoni are reported. In case 1 the onset and the evolution of the disease assumed a progressive character; the neurologic examination showed a picture similar to the Brown-Sequard syndrome. In case 2 the onset was acute and the neurologic examination has shown a complete transverse myelopathy syndrome at the middle toracic level. The cerebrospinal fluid examination showed in the two cases: cells counts increased, normal or low sugar and increased protein. The study of CSF protein profile showed increased gamma-globulin in the two cases. The immunological reactions in the blood and CSF were positive in the two cases. Good results were obtained with especific therapy.

Registro de um caso de carcinomatose meníngea. O diagnóstico foi estabelecido pela evolução e pelo encontro de células neoplásicas no líquido cefalorraqueano. A necropsia mostrou existir carcinoma papilífero do estômago, com metástases nas supra-renais, no espaço retroperitonial, no espaço sub-aracnóideo comprometendo raízes nervosas, nas paredes e na luz de vasos linfáticos, na espessura da dura-mater e no tecido nervoso medular.

A case of carcinoma of the meninges, diagnosed through the clinical picture and the finding of neoplastic cells in the cerebrospinal fluid is reported. The post-mortem examination showed a papillary carcinoma of the stomach with metastases in the retroperitoneal space, in the subarachnoideal space infiltrating the spinal roots, in the lymphatic vessels of the nerve trunks, in the dura-mater and the spinal cord.