Pesquisa | SciELO

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

Efecto de la exposición previa a COVID-19, ocurrencia de brotes y tipo de vacuna en la respuesta inmune humoral de adultos mayores institucionalizados
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Aguirre, Fernanda

; Marro, María Jimena

; Rodriguez, Pamela E.

; Rall, Pablo

; Miglietta, Esteban A.

; Miranda, Lucía A. López

; Poncet, Verónica

; Pascuale, Carla A.

; Ballejo, Christian A.

; Ricardo, Tamara

; Miragaya, Yanina

; Gamarnik, Andrea

; Rossi, Andrés H.

; Silva, Andrea P.

Cadernos de Saúde Pública

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2024, Volume 40 Nº 9 elocation e00155023

Resumo: Es Pt En | Texto: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: El objetivo de este trabajo fue evaluar los factores explicativos de la respuesta inmune humoral en adultos mayores de establecimientos de estancia prolongada de Buenos Aires, Argentina, hasta 180 días post vacunación. Se utilizó un diseño de cohorte abierta, prospectiva, multicéntrica, con voluntarios que recibieron dos dosis de vacunas Sputnik V, Sinopharm o AZD1222. Se analizaron muestras de plasma en los tiempos 0, 21 días post primera dosis, 21 días post segunda dosis, 120 y 180 días post primera dosis. Se ajustaron modelos lineales marginales y aditivos generalizados mixtos para evaluar el comportamiento de la concentración de anticuerpos IgG anti-Spike en el tiempo según grupo de exposición (naïve/no-naïve) y vacuna. Las covariables analizadas fueron: ocurrencia de brote de COVID-19 en establecimientos de estancia prolongada y comorbilidades. Se incluyeron en el análisis 773 participantes con una mediana de edad de 83 años (RIQ: 76-89). Al final del estudio, los niveles de anticuerpos del grupo naïve: Sinopharm fueron significativamente menores que el resto de los grupos (p < 0,05); los del no-naïve: Sinopharm resultaron similares a los naïve que recibieron AZD1222 (p = 0,945) o Sputnik V (p = 1). Los participantes expuestos a brotes en establecimientos de estancia prolongada presentaron niveles de anticuerpos significativamente mayores, independientemente del grupo de exposición y la vacuna (p < 0,001). Concluimos que la exposición previa a COVID-19, el tipo de vacuna y la pertenencia a un establecimiento de estancia prolongada con antecedente de brote son factores a considerar frente a futuros eventos epidémicos con dinámicas de transmisión y mecanismos inmunológicos similares al COVID-19, en poblaciones similares a la analizada en este trabajo.

Resumo: Este estudo teve como objetivo avaliar os fatores explicativos da resposta imune humoral em idosos em instituições de longa permanência em Buenos Aires, Argentina, até 180 dias após a vacinação. Foi realizado um estudo de coorte aberto, prospectivo e multicêntrico, com voluntários que receberam duas doses das vacinas Sputnik V, Sinopharm ou AZD1222. As amostras de plasma foram analisadas nos tempos 0, 21 dias após a primeira dose, 21 dias após a segunda dose, 120 e 180 dias após a primeira dose. Os modelos lineares marginais e os aditivos generalizados mistos foram ajustados para determinar o comportamento da concentração de anticorpos IgG anti-Spike ao longo do tempo de acordo com o grupo de exposição (naïve/no-naïve) e vacina. As covariáveis analisadas foram ocorrência de pico de COVID-19 nas instituições de longa permanência e comorbidades. Foram incluídos 773 participantes, com média de idade de 83 anos (IIQ: 76-89). Os resultados apontaram níveis de anticorpos do grupo naïve: Sinopharm significativamente mais baixos do que os outros grupos (p < 0,05); e as variáveis do grupo no-naïve: Sinopharm foram semelhantes à do grupo naïve que recebeu AZD1222 (p = 0,945) ou Sputnik V (p = 1). Os participantes expostos a picos nas instituições de longa permanência apresentaram níveis de anticorpos significativamente maiores, independentemente do grupo de exposição e da vacina (p < 0,001). Conclui-se que a exposição prévia à COVID-19, tipo de vacina e adesão a uma instituição de longa permanência com histórico de pico são fatores a serem considerados em futuros eventos epidêmicos com dinâmica de transmissão e mecanismos imunológicos semelhantes à COVID-19, em populações semelhantes à analisada neste trabalho.

Abstract: This study evaluated the explanatory factors of humoral immune response in older adults admitted to long-term care institutions in Buenos Aires, Argentina, up to 180 days after vaccination. An open-label, prospective, multicenter cohort study was conducted with volunteers who received two doses of the Sputnik V, Sinopharm, or AZD1222 vaccines. Plasma samples were analyzed at 0 and 21 days after the first dose, 21 days after the second dose, and 120 and 180 days after the first dose. Marginal linear models and generalized additives mixed models were adjusted to determine the behavior of anti-spike IgG antibody concentration over time according to exposure group (naïve/no-naïve) and vaccine. Occurrence of an outbreak of COVID-19 in long-term care institutions and comorbidities were the covariates analyzed. A total of 773 participants were included, with a mean age of 83 years (IQR: 76-89). Results showed that antibody levels in the naïve: Sinopharm group were significantly lower to the other groups (p < 0.05). Antibody levels in the no-naïve: Sinopharm group were similar to those in the naïve group who received AZD1222 (p = 0.945) or Sputnik V (p = 1). Participants exposed to outbreaks in long-term care institutions had significantly higher antibody levels, regardless of exposure group and vaccine (p < 0.001). In conclusion, previous exposure to COVID-19, type of vaccine, and admittance into a long-term care institution with a history of outbreaks are factors to be considered in future epidemic events with transmission dynamics and immunological mechanisms similar to COVID-19, in populations similar to the one analyzed.

https://doi.org/10.1590/0102-311xes155023

Efecto de la exposición previa a COVID-19, ocurrencia de brotes y tipo de vacuna en la respuesta inmune humoral de adultos mayores institucionalizados COVID19, COVID19 COVID 19, 19 COVID-19 COVID1 1 COVID-1 COVID-
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Aguirre, Fernanda

; Marro, María Jimena

; Rodriguez, Pamela E.

; Rall, Pablo

; Miglietta, Esteban A.

; Miranda, Lucía A. López

; Poncet, Verónica

; Pascuale, Carla A.

; Ballejo, Christian A.

; Ricardo, Tamara

; Miragaya, Yanina

; Gamarnik, Andrea

; Rossi, Andrés H.

; Silva, Andrea P.

Cadernos de Saúde Pública

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2024, Volume 40 Nº 9 elocation e00155023

Resumo: Es Pt En | Texto: Es Pt En | PDF: Es | PDF: Pt | PDF: En

https://doi.org/10.1590/0102-311xes155023

CO2 monitor for measurement of ventilation in closed environments, COVID-19 prevention, and improvement of work performance
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Vorobioff, Juan

; Boggio, Norberto Gabriel

; Checozzi, Federico Ricardo

; Pinto Garrón, Tamara

; Rinaldi, Carlos Alberto

Tecnura

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Dez 2023, Volume 27 Nº 78 Páginas 142 - 156

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Objective: Humans produce and exhale CO2, thus the concentration of this gas increases in closed environments. The CO2 concentration of air is often used as a reference to measure the ventilation rate. The typical outdoor CO2concentration is approximately 400 ppm, although it can be as high as 500 ppm. Concentrations greater than 20000 ppm result in Deep breathing, higher than 100000 ppm cause visual disturbances and tremors with possible loss of consciousness and over250000 ppm may cause death. In buildings with no change on their ventilation rate, high CO2concentrations have negative effects on decision making and working performance. At 1000 ppm, performance is significantly reduced in six of nine decision making metrics compared to 600 ppm. In this work, a CO2 flexible monitor is designed to measure ventilation in closed environments. Methodology: Electrolytic and infrared CO2sensors with a detection range of 350 to up to 10000 ppm were used. The used sensors have good sensitivity and selectivity to CO2. The gas monitor has a simple calibration system, whereby software automatically adjusts the calibration curve parameters after circulating clean air. The design of a gas bench used to verify sensor calibration is also shown. Results: A set of measurements were performed with electrochemical gas sensors and infrared (IR) gas sensors to test the functionality of the equipment. Experimental work has shown sensors have a satisfactory response for this application. The margins of error are +5% of the reading value. Conclusions: A low cost, flexible gas monitor for indoor environments like schools, offices, laboratories, and industries was designed in this work. Due to the flexible design, a network of gas monitors strategically distributed in the different spaces of the buildings is proposed. Fundings: Universidad Tecnológica Nacional. Comisión Nacional de Energía Atómica. Buenos Aires, Argentina.

Resumen Objetivo: Los humanos producimos y exhalamos CO2, por lo que la concentración de este gas aumenta en ambientes cerrados. La concentración de gas CO2en el aire se utiliza a menudo como referencia para medir la tasa de ventilación. La concentración típica de CO2al aire libre es de aproximadamente 400 ppm, aunque puede llegar a 500 ppm. Las concentraciones superiores a 20000 ppm dan como resultado una respiración profunda, superiores a 100000 ppm provocan alteraciones visuales y temblores con posible pérdida del conocimiento y superiores a 250000 ppm pueden provocar la muerte. En edificios sin cambios en su tasa de ventilación, las altas concentraciones de CO2 tienen efectos negativos en la toma de decisiones y el rendimiento laboral. A 1000 ppm, el rendimiento se reduce significativamente en seis de las nueve métricas de toma de decisiones en comparación con 600 ppm. En este trabajo se diseña un monitor flexible de CO2 paramedir la ventilación en ambientes cerrados. Metodología: Se utilizaron sensores de CO2 electrolíticos y sensores infrarrojos con un rango de detección de 350 hasta10000 ppm. Los sensores utilizados tienen buena sensibilidad y selectividad al CO2. El monitor de gas tiene un sistema de calibración simple, mediante el cual el software ajusta automáticamente los parámetros de la curva de calibración después de hacer circular aire limpio. También se muestra el diseño de un banco de gases utilizado para verificar la calibración del Resultados: Se realizaron un conjunto de mediciones, con sensores de gases electrolíticos químicos y sensores de gases infrarrojos (IR) probando la funcionalidad del equipo. El trabajo experimental ha demostrado que los sensores tienen una respuesta satisfactoria para esta aplicación. Los márgenes de error son 5% del valor de lectura. Conclusiones: En este trabajo se diseñó un monitor de gas flexible y de bajo costo para ambientes interiores como escuelas, oficinas, laboratorios e industrias. Debido al diseño flexible, se propone una red de monitores de gas distribuidos estratégicamente en los distintos espacios de los edificios. Financiamiento: Universidad Tecnológica Nacional. Comisión Nacional de Energía Atómica. Buenos Aires, Argentina.

https://doi.org/10.14483/22487638.19522

Adaptación y Validación del Examen de Estado Mental del Autismo (AMSE) en Chile: buscando reducir la brecha diagnóstica
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Irarrázaval, Matías

; López, Isabel

; Figueroa, Cecilia

; Cabezas, Marcia

; Yáñez, Cristián

; Rodillo, Eliana

; Riesle, Sofia

; Rivera, Tamara

; Garcia, Ricardo

Andes pediatrica

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Ago 2023, Volume 94 Nº 4 Páginas 475 - 484

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen: La detección precoz del Autismo es un desafío en Chile y América Latina. Las evaluaciones gold-standard son de alto costo y difícil disponibilidad. El Examen de Estado Mental para Autismo (AMSE) es un instrumento breve, estructurado, observacional, para uso clínico con promisorios resultados. Objetivo: Adaptar y validar AMSE en muestra de niños, niñas y adolescentes (NNA) hispanohablantes con riesgo de Espectro Autista (EA) utilizando como comparación ADOS-2. Sujetos y Métodos: NNA de 15m-17a, consultantes por problemas de lenguaje, comunicación y/o sospecha de EA. AMSE fue administrado durante evaluación clínica. ADOS-2 fue administrado por evaluadores independientes, ciegos, determinando categorías: No Espectro Autista (NoEA), Espectro Autista (EA) o Autismo (AUT). Se evaluó características psicométricas de AMSE y usando curva ROC se calculó punto de corte, identificando sensibilidad, especificidad, valor predictivo positivo y negativo. Resultados: Participaron 64 NNA, 56 varones (87,5%), con edad promedio 6,6 años (DE:3,6). Se distribuyeron según ADOS-2 en NoEA:12 (18,8%), EA:19 (29,7%), AUT:33 (51,6%). Los puntajes AMSE difirieron significativamente entre las tres categorías (p < 0,0001). AMSE tuvo consistencia interna moderada, con Alfa de Cronbach 0,61. Punto de corte ≥ 6 puntos (sensibilidad 0,79 especificidad 0,92, AUC: 0,91). Un segundo análisis según nivel de lenguaje sugiere mayor precisión diagnóstica de AMSE para el grupo con menor desarrollo de lenguaje, manteniéndose punto de corte óptimo de ≥ 6 puntos. Conclusión: AMSE muestra adecuadas propiedades psicométricas, buena capacidad y precisión para respaldar el diagnóstico de EA. Su brevedad, bajo costo y fácil integración a la práctica clínica, lo hacen una alternativa de gran potencial para el reconocimiento y derivación oportunos de NNA en EA.

Abstract: Early detection of Autism is a challenge in Chile and Latin America. Gold-standard evaluations are expensive and difficult to access. The Autism Mental Status Exam (AMSE) is a brief, structured, observational instrument for clinical use with promising results. Objective: To adapt and validate the AMSE in a sample of Spanish-speaking children and adolescents at risk of Autism Spectrum Disorder (ASD) using the ADOS-2 as a comparison. Subjects and Method: Children and adolescents aged 15m-17yo consulting due to language and communication problems and/or suspected ASD. The AMSE was administered during clinical evaluation. The ADOS-2 was administered by independent evaluators, blinded to the study, which determined diagnostic categories as: Non-Autism Spectrum Disorder (Non-ASD), Autism Spectrum Disorder (ASD), or Autism (AUT). Psychometric characteristics of the AMSE were assessed and, using the ROC curve, a cut-off point was calculated, identifying sensitivity, specificity, positive, and negative predictive value. Results: Sixty-four children participated, 56 were males (87.5%), with a mean age of 6.6y (SD: 3.6). They were distributed as Non- ASD: 12 (18.8%), ASD: 19 (29.7%), and AUT: 33 (51.6%) according to the ADOS-2. The AMSE scores differed significantly among the three categories (p<0.0001). Internal consistency was moderate and Cronbach’s alpha was 0.61. The cut-off point was ≥ 6 (Sensitivity 0.79, Specificity 0.92, AUC: 0.91). A second analysis according to language level suggests a greater diagnostic accuracy of the AMSE for the group with lower language development, maintaining the same optimal cut-off point (≥6). Conclusions: The AMSE shows adequate psychometric properties, good capacity, and accuracy to support the diagnosis of ASD. Its brevity, low cost, and easy integration into clinical practice make it an alternative with great potential for timely recognition and referral of children with ASD.

https://doi.org/10.32641/andespediatr.v94i4.4476

Evaluación del tratamiento quirúrgico en las fracturas de la pared posterior del acetábulo
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Rodríguez Buenaventura, Gilberto Antonio

; Álvarez Benito, Octavio

; Loredo Quesada, Tamara

; Copete Ramos, Ricardo Alexis

; Coronados Valladares, Yuneisys

Revista Cubana de Ortopedia y Traumatología

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Mar 2023, Volume 37 Nº 1 elocation e592

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Fractures of the acetabulum are a frequent traumatic condition in the emergency service. Objective: To evaluate the evolution of patients with fractures of the posterior wall of the acetabulum after surgical management. Method: A quasi-experimental study was conducted in 32 patients with fractures of the posterior wall of the acetabulum, whom were surgically operated in the Orthopedics and Traumatology Service of "Calixto García" Hospital. Descriptive and inferential statistical methods were used. Results: The group of 40 to 49 years, the male sex, the type II fracture and, in the etiology, traffic accidents predominated. The osteosynthesis technique with reconstruction plate plus interfragmentary screws was used in most cases. The main complication was surgical wound infection. 81.2 % of patients progressed satisfactorily. Conclusions: After surgical treatment, fractures of the posterior wall of the acetabulum evolve satisfactorily. The osteosynthesis technique with reconstruction plate plus interfragmentary screws showed better results than that of interfragmentary screws alone.

RESUMEN Introducción: Las fracturas del acetábulo constituyen una afección traumática frecuente en el servicio de urgencia. Objetivo: Evaluar la evolución de los pacientes con fracturas de la pared posterior del acetábulo después del manejo quirúrgico. Método: Se realizó un estudio cuasiexperimental en 32 pacientes con fracturas de la pared posterior del acetábulo, intervenidos quirúrgicamente en el Servicio de Ortopedia y Traumatología del Hospital “Calixto García”. Se utilizaron métodos de estadística descriptiva e inferencial. Resultados: Predominaron el grupo de 40 a 49 años, el sexo masculino, la fractura tipo ii y, en la etiología, el accidente de tránsito. La técnica de osteosíntesis con placa de reconstrucción más tornillos interfragmentarios se utilizó en la mayoría de los casos. La principal complicación fue la infección de la herida quirúrgica. El 81,2 % de los pacientes evolucionó satisfactoriamente. Conclusiones: Después del tratamiento quirúrgico, las fracturas de la pared posterior del acetábulo evolucionan de forma satisfactoria. La técnica de osteosíntesis con placa de reconstrucción más tornillos interfragmentarios mostró mejores resultados que la de tornillos interfragmentarios solamente.

First official record of Aedes (Stegomyia) albopictus (Diptera: Culicidae) in the Acre State, Northern Brazil Stegomyia (Stegomyia Diptera (Diptera Culicidae State
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Rocha, Ricardo da Costa

; Cardoso, Acigelda da Silva

; Souza, Janis Lunier de

; Pereira, Eliana da Silva

; Amorim, Marcio Fernandes de

; Souza, Maria Socorro Martins de

; Medeiros, Cleomar de Lima

; Monteiro, Maria Francisca Mendes

; Meneguetti, Dionatas Ulises de Oliveira

; Paula, Marcia Bicudo de

; Brilhante, Andreia Fernandes

; Lima-Camara, Tamara Nunes

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e20

Resumo: En | Texto: En | PDF: En

ABSTRACT Aedes (Stegomyia) albopictus (Skuse, 1854) was reported in Brazil for the first time in 1986 and has shown marked expansion throughout the Brazilian territory. During a routine activity to control dengue fever conducted by the Division of Entomology of the Municipal Health Department in Rio Branco city, adults and immatures of Culicidae were collected in a peri-urban area. The identified Culicidae forms indicated that they belonged to the species Ae. albopictus. This is the first official record of the presence of Ae. albopictus in the Acre State, confirming its current presence in all Brazilian states. Stegomyia (Stegomyia Skuse, Skuse (Skuse 1854 198 territory city periurban peri urban area Ae State states 185 19 18 1

https://doi.org/10.1590/s1678-9946202365020

Acquired enamel pellicle protects gastroesophageal reflux disease patients against erosive tooth wear
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MARTINI, Tatiana

; RIOS, Daniela

; DIONIZIO, Aline

; CASSIANO, Luiza de Paula Silva

; SILVA, Cíntia Maria de Souza e

; TAIRA, Even Akemi

; VENTURA, Talita Mendes Oliveira

; CÂMARA, João Victor Frazão

; Araujo, Tamara Teodoro

; MAGALHÃES, Ana Carolina

; CARVALHO, Thiago Saads

; BAUMANN, Tommy

; LUSSI, Adrian

; OLIVEIRA, Ricardo Brandt de

; PALMA-DIBB, Regina Guenka

; BUZALAF, Marília Afonso Rabelo

Brazilian Oral Research

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2023, Volume 37 elocation e085

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW). Twenty-four volunteers were divided into 3 groups: 1) GERD and ETW; 2) GERD without ETW; and 3) control (without GERD). The AEP formed 120 min after prophylaxis was collected from the lingual/palatal surfaces. The samples were subjected to mass spectrometry (nLC-ESI-MS/MS) and label-free quantification by Protein Lynx Global Service software. A total of 213 proteins were identified, or 119, 92 and 106 from each group, respectively. Group 2 showed a high number of phosphorylated and calcium-binding proteins. Twenty-three proteins were found in all the groups, including 14-3-3 protein zeta/delta and 1-phosphatidylinositol. Several intracellular proteins that join saliva after the exfoliation of oral mucosa cells might have the potential to bind hydroxyapatite, or participate in forming supramolecular aggregates that bind to precursor proteins in the AEP. Proteins might play a central role in protecting the dental surface against acid dissolution. (AEP GERD, , (GERD) ETW. ETW . (ETW) Twentyfour Twenty four groups 1 GERD. GERD) 12 lingualpalatal lingual palatal surfaces nLCESIMS/MS nLCESIMSMS nLC ESI MS/MS MS (nLC-ESI-MS/MS labelfree label free software 21 identified 119 9 10 group respectively calciumbinding calcium binding Twentythree three 1433 14 14-3- zetadelta zeta delta 1phosphatidylinositol. 1phosphatidylinositol phosphatidylinositol phosphatidylinositol. 1-phosphatidylinositol hydroxyapatite dissolution (GERD (ETW nLCESIMS MSMS 11 143 14-3 14-

https://doi.org/10.1590/1807-3107bor-2023.vol37.0085

Genotypic selection of pre-clultivars of carioca and early carioca beans for the Agreste-Sertão of Pernambuco, Brazil
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Nascimento, Maxwel Rodrigues

; Santos, Paulo Ricardo dos

; Costa, Antônio Félix da

; Daher, Rogério Figueiredo

; Oliveira, Tâmara Rebecca Albuquerque de

; Souza, Alexandre Gomes de

; Costa, Kleyton Danilo da Silva

; Silva, Katiane da Rosa Gomes da

; Araújo, Emmanuelle Rodrigues

; Santana, Sérgio Rogério Alves de

; Silva, José Wilson da

Ciência Rural

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2023, Volume 53 Nº 6 elocation e20220031

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: A interação genótipo x ambiente representa um grande desafio na identificação e seleção de genótipos responsivos às diversas condições de clima e solo. O objetivo deste trabalho foi avaliar e selecionar pré-cultivares de feijão carioca e feijão carioca precoce com base na adaptabilidade, estabilidade e produtividade de grãos. Na safra 2014 foram conduzidos dois ensaios regionais de competição no estado de Pernambuco: feijão carioca (14 genótipos em Arcoverde, Belém de São Francisco, Caruaru e São João) e feijão carioca precoce (11 genótipos em Araripina, Arcoverde e Caruaru) e na safra de 2015 com feijão carioca precoce (11 genótipos, em Araripina, Arcoverde e Brejão). Os parâmetros foram estimados por meio de modelos mistos e a seleção foi realizada pelo método da Média Harmônica do Desempenho Relativo dos Valores Genéticos (MHPRVG), adotando-se três estratégias: i) seleção com base no valor genético predito, sem interação; ii) seleção com base no valor genético predito, considerando cada local; iii) seleção simultânea quanto à produtividade de grãos, adaptabilidade e estabilidade. Observou-se que os ambientes influenciaram na expressão fenotípica dos genótipos de feijão carioca e carioca precoce, configurando adaptação específica. Os genótipos BRS Notável, BRS Estilo e BRS Pérola, de feijão carioca, e CNFC 15875, BRS Notável e CNFC 15630, de feijão carioca precoce, apresentaram os melhores desempenhos nos ambientes testados, considerando-se, simultaneamente, a adaptabilidade a diferentes condições edafoclimáticas, estabilidade de desempenho e produtividade de grãos.

ABSTRACT: Genotype x environment interactions represent a major challenge in identifying and selecting genotypes responsive to different climate and soil conditions. This research evaluated and selected pre-cultivars of carioca bean and early carioca bean based on adaptability, stability, and grain yield. In the 2014 crop season, two regional competition trials were conducted in the state of Pernambuco: carioca beans (14 genotypes in Arcoverde, Belém de São Francisco, Caruaru and São João) and early carioca beans (11 genotypes in Araripina, Arcoverde, and Caruaru) and, in the 2015 crop season, with early carioca beans (11 genotypes in Araripina, Arcoverde, and Brejão). Parameters were estimated by mixed models, and the selection was performed using the Harmonic Mean of Relative Performance of Genetic Values (HMRPGV) method following three strategies: i) selection based on predicted genetic value with no interaction; ii) selection according to predicted genetic value considering each location; and iii) simultaneous selection for grain yield, adaptability, and stability. The environments influenced the phenotypic expression of the carioca and early carioca bean genotypes, representing a specific adaptation. The genotypes BRS Notável, BRS Estilo and BRS Pérola, of carioca beans, and CNFC 15875, BRS Notável and CNFC 15630, of early carioca beans, had the best results in the environments tested, regarding, simultaneously, adaptability to different soil and climate conditions, performance stability, and grain yield.

https://doi.org/10.1590/0103-8478cr20220031

10.

Preparation of PLGA Nanoparticles Loaded with the Anti-Infective Ctn[15-34] Peptide for Antifungal Application AntiInfective Anti Infective Ctn1534 Ctn 15 34 Ctn[15-34 Ctn153 1 3 Ctn[15-3 Ctn15 Ctn[15- Ctn1 Ctn[15 Ctn[1 Ctn[
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Santos, Ana Paula dos

; Oliveira, Roberta Carolina Rangel de

; Louchard, Bianca Oliveira

; Uchoa, Antônia Flávia Justino

; Ricardo, Nágila Maria Pontes Silva

; Leal, Luzia Kalyne Almeida Moreira

; Rádis-Baptista, Gandhi

; Araújo, Tamara Gonçalves de

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e20220775

Resumo: En | Texto: En | PDF: En

Abstract This article aims to report the preparation and optimized formulation of Ctn[15-34], a designed anti-infective peptide, with poly(lactic acid-co-glycolic acid), PLGA, nanoparticles. Ctn[15-34] is a short peptide derived from crotalicidin, a cathelicidin-related antimicrobial peptide from the venom of the South American rattlesnake (Crotalus durissus terrificus), that has arisen as a promising antifungal and microbicide agent. The PLGA nanoparticles were prepared and loaded with carboxyfluorescein (CF)-Ctn[15-34] using the double emulsion/solvent evaporation method. After a preformulation study, which tested different formulation parameters, Poly (vinyl alcohol) 87-89% hydrolyzed and sonication with Sonifier® were choosen to prepare unloaded PLGA nanoparticles by that method, resulting in smaller particle size and Polydispersity Index (PDI) values and higher zeta potential values of nanoparticles. This better condition was used to prepare CF-Ctn[15-34]-loaded PLGA nanoparticles, resulting in homogeneous and spherical nanoparticles, with an average size of 213.2 ± 2.00 nm, PDI of 0.044 ± 0.04 and zeta potential of -16.03 ± 1.20 mV. An excellent encapsulation efficiency was obtained, corresponding to 93.3 ± 0.10 %. The drug-release profile showed a rapid initial release of the peptide, approximately 27 % in the first 24 hours, followed by a sustained release for at least 16 days. Another relevant aspect in the peptide formulation is that the CF-Ctn[15-34]-loaded nanoparticles potentiated the antifungal effect against the opportunistic pathogenic yeast Cryptococcus neoformans compared with the free, in solution Ctn[15-34], in equivalent volume dosage. A preparation method of CF-Ctn[15-34]-loaded PLGA nanoparticles was established and validated, representing a successful approach to deliver CF-Ctn[15-34] for pharmaceutical applications. Ctn1534, Ctn1534 Ctn 15 34 , antiinfective anti infective polylactic poly lactic acidcoglycolic acid co glycolic acid, acid) Ctn[15-34 crotalicidin cathelicidinrelated cathelicidin related Crotalus terrificus, terrificus terrificus) agent CFCtn1534 CFCtn CF (CF)-Ctn[15-34 emulsionsolvent emulsion solvent study parameters vinyl alcohol 8789% 8789 87 89% 89 87-89 Sonifier (PDI CFCtn1534loaded CFCtnloaded 2132 213 2 213. 200 00 2.0 nm 0044 0 044 004 04 0.0 16.03 1603 03 -16.0 120 1 20 1.2 mV obtained 933 93 3 93. 010 10 0.1 drugrelease drug hours days free dosage validated CF-Ctn[15-34 applications Ctn153 Ctn[15-3 CFCtn153 (CF)-Ctn[15-3 878 8 87-8 21 2. 0. 16.0 160 -16. 12 1. 9 01 CF-Ctn[15-3 Ctn15 Ctn[15- CFCtn15 (CF)-Ctn[15- 87- 16. -16 CF-Ctn[15- Ctn1 Ctn[15 CFCtn1 (CF)-Ctn[15 -1 CF-Ctn[15 Ctn[1 (CF)-Ctn[1 - CF-Ctn[1 Ctn[ (CF)-Ctn[ CF-Ctn[ (CF)-Ctn CF-Ctn

https://doi.org/10.1590/1678-4324-2023220775

11.

Linseed Oil Nanoemulsion with Pluronic® F127 Loaded with Betulinic Acid: Preparation, Rheology, MTT Assay and in vitro Release Kinetics
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Rebouças, Louhana M.

; Sousa, Alexandre C. C.

; Gramosa, Nilce V.

; Araújo, Tamara G. de

; Oliveira, Fátima de Cássia E. de

; Pessoa, Cláudia do Ó

; Araújo, Rinaldo S.

; Santos, Emília M. A.

; Ricardo, Nágila M. P. S.

Journal of the Brazilian Chemical Society

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Nov 2022, Volume 33 Nº 11 Páginas 1319 - 1331

Resumo: En | Texto: En | PDF: En

The main objective of this work was to develop a nanoemulsion based on linseed oil and betulinic acid, stabilized with Pluronic F127 and polyglycerol polyricinoleate, for anticancer applications. The nanoemulsions were synthesized by ultrasound and evaluated for in vitro cytotoxicity, particle size, polydispersity index, zeta potential, morphology, encapsulation efficiency, storage stability, rheology and in vitro release kinetics. In vitro cytotoxicity assays were performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (72 h) against HCT-116 (colorectal carcinoma), SNB-19 (glioblastoma), NCI-H460 (lung carcinoma) and L-929 (normal fibroblasts) cells. The determination of 50% inhibitory concentration (IC50) showed an increased selectivity for the emulsified betulinic acid when compared to its free form for the HCT-116 cells. The IC50 values for the synthesized nanoemulsions showed a range from 3.2 to 3.7 µM (HCT-116), 5.6 and 11.5 µM (NCI-H460), 5.8 and 7.3 µM (SNB-19) and > 16.5 µM for normal fibroblasts. In the 48 h in vitro release assays, it presented controlled release explained by the Korsmeyer-Peppas model, releasing 572.25 and 619.95 µg of betulinic acid in a controlled way, generating promising perspectives for the prolonged release of betulinic acid in anticancer applications.

https://doi.org/10.21577/0103-5053.20220063

12.

Consenso chileno de diagnóstico y manejo de neoplasias quísticas pancreáticas. Club de páncreas Chile-SCHGE
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Espino, Alberto

; Vargas, José Ignacio

; Mancilla, Carla

; Muñoz, Pablo

; Martínez, Waldo

; Menéndez, Alejandra

; Jara, Daniela

; Mansilla, Rodrigo

; Schiappacasse, Giancarlo

; Santamarina, Mario

; Huete, Álvaro

; Candia, Roberto

; Silva, Felipe

; Castillo, Cecilia

; Richter, Hugo

; Mejía, Ricardo

; Vial, Paula

; Robles, Ignacio

; Martínez, Jorge

; Jarufe, Nicolás

; Briceño, Eduardo

; Lembach, Hanns

; Zoroquiain, Pablo

; Roa, Juan Carlos

; Walker, Kenneth

; Torres, Javiera

; Carreño, Laura

; Castiblanco, Adriana

; Fernández, Wanda

; Ríos, Álvaro

; Chandia, Javiera

; Ayala, María José

; Rojas, Tamara

; Verdugo, Jorge

; Berger, Zoltán

Revista médica de Chile

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Dez 2021, Volume 149 Nº 12 Páginas 1773 - 1786

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Pancreatic cystic neoplasms (PCN) are frequently detected on abdominal images performed for non-pancreatic indications. Their prevalence in asymptomatic population ranges from 2.7 to 24.8%, and increases with age. There are several types of pancreatic cysts. Some may contain cancer or have malignant potential, such as mucinous cystic neoplasms, including mucinous cystadenoma (MCN) and intraductal papillary mucinous neoplasms (IPMN). In contrast, others are benign, such as serous cystadenoma (SCA). However, even those cysts with malignant potential rarely progress to cancer. Currently, the only treatment for pancreatic cysts is surgery, which is associated with high morbidity and occasional mortality. The Board of the Chilean Pancreas Club of the Chilean Gastroenterology Society developed the first Chilean multidisciplinary consensus for diagnosis, management, and surveillance of PCN. Thirty experts were invited and answered 21 statements with five possible alternatives: 1) fully agree; 2) partially agree; 3) undecided; 4) disagree and 5) strongly disagree. A consensus was adopted when at least 80% of the sum of the answers “fully agree” and “partially agree” was reached. The consensus was approved by the Board of Directors of the Chilean Pancreas Club for publication.

https://doi.org/10.4067/s0034-98872021001201773 73 downloads

13.

Spondias purpurea L. Stem Bark Extract: Antioxidant and in vitro Photoprotective Activities
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Rodrigues, Francisco Alessandro M.

; Giffony, Priscylla S.

; Santos, Sarah B. F. dos

; Guedes, Jhonyson A. C.

; Ribeiro, Maria Elenir N. P.

; Araújo, Tamara G. de

; Silva, Larissa M. R. da

; Zocolo, Guilherme J.

; Ricardo, Nágila M. P. S.

Journal of the Brazilian Chemical Society

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Out 2021, Volume 32 Nº 10 Páginas 1918 - 1930

Resumo: En | Texto: En | PDF: En

Plant phenolic extracts are widely recognized as an important source of natural antioxidant substances and potential compounds for cosmetic formulations. This study aimed to evaluate the chemical profile, photoprotective and antioxidant activities of stem bark extract of Spondias purpurea L. (ciriguela) and its application in photoprotective formulations. Thirty phenolic constituents were annotated by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry in mode negative (UPLC-QTOF-MS2). The stem bark extract antioxidant and chelation potential, expressed in half maximal inhibitory concentration (IC50), showed 6.25 and 352.22 µg mL−1, respectively. The phenolic extract was used as an active ingredient in six sunscreen formulations, with concentrations ranging from 0.2 to 10%. The ultraviolet (UV) protection properties of the formulations were evaluated by sun protection factor (SPF) values obtained in 0.2 mg mL−1 (0.495 to 2.27) and 2.0 mg mL−1 (2.29 to 15.87). The SPF value for the extract (14.37 and 26.16) was high, but there was a reduction in the base formulation. However, these results suggested that the bioactive extracted of stem bark of Spondias purpurea L. has interesting potential to reduce the damage caused by UV radiation and may be utilized as an active ingredient in a sunscreen formulation.

https://doi.org/10.21577/0103-5053.20210082 46 downloads

14.

Respuesta del ñame espino a diferentes densidades de siembra y altura de espalderas: densidades de siembra en Dioscorea rotundata
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Tamara Morelos, Ricardo Enrique

; Luna Castellanos, Lily Lorena

; Aroldo Espitia Montes, Amaury

; Novoa Yanez, Rafael Segundo

; Regino Hernández, Sol Mara

; De la Ossa Albis, Víctor Alfonso

Revista de Investigaciones Altoandinas

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Out 2021, Volume 23 Nº 4 Páginas 210 - 219

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract The tubers of spiny yam are one of the main food sources for producers in the Caribbean region of Colombia. However, the productivity of the crop is low due to the scarce use of sustainable management practices that contribute to its improvement. In this sense, a study was conducted at the Turipaná Research Center of Agrosavia, El Carmen de Bolívar, with the objective of evaluating the response in yield of purple stalk hawthorn yam cv. purple stalk to different planting densities and trellis heights. Six treatments were evaluated in a randomized complete block experimental design with a split plot arrangement, the main plot corresponded to two densities (14,285 plants ha-1 and 20,000 plants ha-1) and the subplots to three trellis heights (1.6 m; 2.0 m and 2.4 m). Planting density was the only factor that significantly influenced yield; the use of 20,000 plants ha-1 increased yield by 28.68% compared to the lowest density. The use of supports with heights of 2.4 m in combination with either of the two planting densities induced the production of tubers unsuitable for commercialization. The findings of this research suggest that increasing plant density could be a safe measure to increase yields and economic efficiency in the cultivation of hawthorn yam. Future evaluations are needed on stand height and number of plants to tie per stand.

Resumen Los tubérculos de ñame espino constituyen uno de los principales sustentos alimenticios de los productores en la región Caribe de Colombiana. Sin embargo, la productividad del cultivo es baja debido a la escasa utilización de prácticas de manejo sustentables que contribuyan a su mejora. En este sentido, se realizó un estudio en el Centro de Investigación Turipaná de Agrosavia, Sede El Carmen de Bolívar con el objetivo de evaluar la respuesta en rendimiento del ñame espino cv. Tallo morado a diferentes densidades de siembra y altura de espalderas. Se evaluaron 6 tratamientos en un diseño experimental de bloques completos al azar con arreglo en parcelas divididas, la parcela principal correspondió a dos densidades (14.285 plantas ha-1 y 20.000 plantas ha-1) y las subparcelas a tres alturas de espalderas (1,6 m; 2,0 m y 2,4 m). La densidad de siembra fue el único factor que influyó de manera significativa en el rendimiento, la utilización de 20.000 plantas ha-1 permitió incrementar en 28,68% el rendimiento en comparación con la menor densidad. La utilización de soportes con alturas de 2,4 m en combinación con alguna de las dos densidades de siembra indujo la producción de tubérculos no aptos para la comercialización. Los hallazgos de esta investigación sugieren que el aumento de la densidad de las plantas podría ser una medida segura para aumentar los rendimientos y la eficiencia económica del cultivo de ñame espino. Se requieren evaluaciones futuras en torno a la altura de soportes y número de plantas a amarrar por cada soporte.

https://doi.org/10.18271/ria.2021.271

15.

Fundamentos teóricos de Florencia Nightingale sobre higiene de manos. Apuntes para una reflexión en tiempos de COVID-19
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Sánchez García, Zenia Tamara

; Mora Pérez, Yuliett

; González Ricardo, Leoana Lázara

; Torres Esperón, Julia Maricela

; Marrero Rodríguez, José Noel

; Cambil Martín, Jacobo

MediSur

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Out 2021, Volume 19 Nº 5 Páginas 845 - 851

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT A review is presented, from the paradigm of Florencia Nightingale, on her theoretical vision about hand hygiene. The main theoretical aspects expressed by her and her relationship with hand hygiene are analyzed, in addition to exposing, through the analysis of her theoretical contributions, her contribution to the development of nursing not only in Cuba but in the world, showing the importance that has this practice to combat a number of infectious diseases and very specifically COVID-19, since one of the most important measures to break its chain of transmission is precisely hand hygiene.

RESUMEN Se presenta una revisión, desde el paradigma de Florencia Nightingale, sobre su visión teórica acerca de la higiene de manos. Se analizan los principales aspectos teóricos expresados por ella y su relación con la higiene de manos, además de exponer, mediante el análisis de sus aportes teóricos, su contribución al desarrollo de la enfermería no solo en Cuba sino en el mundo, mostrando la importancia que tiene esta praxis para combatir un sin número de enfermedades infecciosas y muy específicamente la COVID-19, pues una de las medidas más importantes para romper su cadena de transmisión es precisamente la higiene de las manos.

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