Pesquisa | SciELO

Abstract Background Strategies aimed at improving the diagnosis and treatment of cardiovascular diseases (CVD) are of utmost importance. Clinical decision support systems (CDSS) are guided by updated guidelines and may be capable of benefiting screening and early diagnosis initiatives in remote regions. Objective To develop a CDSS for screening hypertension and diabetes mellitus (DM), as well as to assess its feasibility and usability in the context of a primary care setting in a resource-constrained region. Methods This research focused on the strategy of screening hypertension and DM based on CDSS. A software was developed and implemented in 10 municipalities in the Northeast of the state of Minas Gerais, Brazil, from April 2017 to October 2018. Patients of 30 to 69 years of age were attended by primary care practitioners using the software. A Likert-scale questionnaire with 15 questions to assess usability (System Usability Scale) and satisfaction was applied to the professionals at the end of study. Groups were compared by applying the chi-squared test for categorical variables. Statistical significance was considered as p < 0.05. Results In the field study, 13,775 individuals were assessed; 185 patients were diagnosed with hypertension; 35 were diagnosed with DM, and 5 were diagnosed with both diseases. For the usability and satisfaction assessment, 258 healthcare professionals participated. Fifty-one percent considered their prior knowledge for the use of technologies to be good; 53.7% reported a desire to use the application frequently, and 78.4% would recommend the platform. Conclusion The implementation of a CDSS developed to assist in the screening of hypertension and DM was feasible in the context of a primary care setting in a resource-constrained region, with good user satisfaction. CVD (CVD importance (CDSS regions , (DM) resourceconstrained resource constrained region 1 Gerais Brazil 201 2018 3 6 Likertscale Likert scale System Scale study chisquared chi squared variables 005 0 05 0.05 13775 13 775 13,77 assessed 18 assessment 25 participated Fiftyone Fifty one 537 53 7 53.7 frequently 784 78 4 78.4 platform (DM 20 00 0.0 1377 77 13,7 2 53. 78. 0. 137 13,

https://doi.org/10.36660/ijcs.20230085

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System. (OMPLs SCC. . (SCC) crosssectional cross sectional North, North (North Northeast CentralWest, CentralWest Central West, West Central-West South. South South) 201 120010 120 010 120,01 20102019, 20102019 , (2010-2019) 69 6 9 6.9 8,321 8321 8 321 (8,32 0.8%, 08 0 (0.8% 95 cases, 4.9%, 49 4 (4.9% 5971 5 971 5,97 1.2%, 12 1 2 (1.2% 1399 399 1,39 Brazils s 64.5%, 645 64.5% 64 (64.5%) located men years level consumption group nonCaucasian non formercurrent former users Institute 99 9.9 Therefore System (SCC 20 12001 01 120,0 2010201 (2010-2019 6. 8,32 832 32 (8,3 0.8% (0.8 4.9% (4.9 597 97 5,9 1.2% (1.2 139 39 1,3 64.5 (64.5% 9. 1200 120, 201020 (2010-201 8,3 83 3 (8, 0.8 (0. 4.9 (4. 59 5, 1.2 (1. 13 1, 64. (64.5 20102 (2010-20 8, (8 0. (0 4. (4 1. (1 (64. (2010-2 ( (64 (2010- (6 (2010 (201 (20 (2

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

Health-Related Quality of Life Reported by Patients With Chagas Disease: A Systematic Review of Qualitative Evidence With GRADE Recommendations
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Silva, Whesley Tanor

; Oliveira, Lucas Frois Fernandes

; Xavier, Diego Mendes

; Figueiredo, Pedro Henrique Scheidt

; Lacerda, Ana Cristina Rodrigues

; Mendonça, Vanessa Amaral

; Ávila, Matheus Ribeiro

; Ferreira Júnior, Cláudio Luiz

; Lima, Márcia Maria Oliveira

; Mediano, Mauro Felippe Felix

; Rocha, Manoel Otávio da Costa

; Costa, Henrique Silveira

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0377-2022

Resumo: En | Texto: En | PDF: En

ABSTRACT Patients with Chagas disease have reduced health-related quality of life (HRQoL). Hence, we aimed to identify the factors that mostly affected their HRQoL. This was a systematic review of qualitative studies. The Latin American and Caribbean Health Sciences Literature, Medical Literature Analysis and Retrieval System Online, Excerpta Medica Database, Web of Science, and SciVerse Scopus databases were searched for relevant studies without language or date restrictions. The search and data analysis were performed by independent reviewers; all qualitative studies that reported the factors that had an impact on the HRQoL of patients with Chagas disease were included. The risk of bias was assessed using the Critical Appraisal Skills Program Qualitative Study Checklist; confidence in the evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation-Confidence in the Evidence from Reviews of Qualitative approach. Five studies were included in this review: four in Brazil and one in California, United States, with immigrants from Central and South America. The sample consisted of 207 patients with chronic Chagas disease. Stigma, physical limitations, work absenteeism, emotional or mental aspects, fear of treatment, and fear of the future had the strongest impact on the HRQoL. All items showed moderate confidence except for fear of treatment (low confidence). The physical, emotional, mental, and cultural aspects affected the HRQoL of patients with chronic Chagas disease. Identification of these factors is important in the development of strategies aimed at improving the HRQoL of this population.

https://doi.org/10.1590/0037-8682-0377-2022

Determinantes da Capacidade Funcional em Pacientes com Doença de Chagas
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Silva, Whesley Tanor

; Costa, Henrique Silveira

; Figueiredo, Pedro Henrique Scheidt

; Lima, Márcia Maria Oliveira

; Lima, Vanessa Pereira

; Costa, Fábio Silva Martins da

; Ávila, Matheus Ribeiro

; Mendonça, Vanessa Amaral

; Lacerda, Ana Cristina Rodrigues

; Nunes, Maria Carmo Pereira

; Rocha, Manoel Otávio Costa

Arquivos Brasileiros de Cardiologia

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Nov 2021, Volume 117 Nº 5 Páginas 934 - 941

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento: A doença de Chagas leva à redução da capacidade funcional. Entretanto, o estágio em que o comprometimento funcional é detectável permanece obscuro. Objetivos: O presente estudo teve como objetivo comparar a capacidade funcional de pacientes em diferentes estágios da doença de Chagas e de indivíduos saudáveis e verificar os determinantes do consumo de oxigênio de pico (VO2pico). Métodos: Em um estudo transversal, foram selecionados 160 indivíduos, 35 saudáveis e 125 com doença de Chagas. No grupo chagásico, 61 (49%) estavam na forma indeterminada da doença, 45 (36%) com cardiomiopatia chagásica (CC) e função cardíaca preservada e 19 (15%) com disfunção cardíaca e CC dilatada. Os dados foram analisados por meio de análise de regressão univariada e multivariada. A significância estatística foi fixada em 5%. Resultados: Pacientes na forma indeterminada da doença apresentaram capacidade funcional semelhante a indivíduos saudáveis (p> 0,05). Pacientes com ChC e função cardíaca preservada apresentaram VO2pico menor que os pacientes na forma indeterminada (p <0,05), mas apresentaram valores de VO2pico semelhantes ao ChC dilatado (p = 0,46). A idade, sexo masculino, classe funcional da NYHA, pressão arterial diastólica, razão entre a velocidade do fluxo transmitral diastólico precoce e a velocidade anular mitral diastólica precoce, a fração de ejeção do ventrículo esquerdo (FEVE) e o diâmetro diastólico final do ventrículo esquerdo foram associados à capacidade funcional. Porém, apenas idade, sexo masculino, FEVE e classe funcional da NYHA permaneceram associados ao VO2pico no modelo final (R2 ajustado = 0,60). Conclusão: Pacientes com CC apresentam menor capacidade funcional do que pacientes na forma indeterminada. FEVE, idade, sexo masculino e classe funcional da NYHA foram determinantes do VO2pico em pacientes com doença de Chagas.

Abstract Background: Chagas disease leads to reduced functional capacity. However, the stage at which functional impairment is detectable remains unclear. Objectives: The present study was addressed to compare the functional capacity of patients at different stages of Chagas disease and healthy individuals and to verify the determinants of peak oxygen uptake (VO2peak). Methods: In a cross-sectional study, 160 individuals were selected, 35 healthy and 125 with Chagas disease. In the Chagasic group, 61 (49%) were in the indeterminate form of the disease, 45 (36%) with Chagas cardiomyopathy (ChC) and preserved cardiac function and 19 (15%) with cardiac dysfunction and dilated ChC. The data were analyzed using univariate and multivariate regression analysis. Statistical significance was set at 5%. Results: Patients in the indeterminate form of disease showed similar functional capacity to healthy individuals (p>0.05). Patients with ChC and preserved cardiac function had lower VO2peak than patients in the indeterminate form (p<0.05), but showed similar VO2peak values than dilated ChC (p=0.46). The age, male sex, NYHA functional class, diastolic blood pressure, ratio of the early diastolic transmitral flow velocity to early diastolic mitral annular velocity, left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter were associated with functional capacity. However, only age, male sex, LVEF and NYHA functional class, remained associated with VO2peak in the final model (adjusted R2=0.60). Conclusion: Patients with ChC had lower functional capacity than patients in the indeterminate form. LVEF, age, male sex and NYHA functional class were determinants with VO2peak in patients with Chagas disease.

https://doi.org/10.36660/abc.20200462 3 downloads

Depressão e ansiedade em profissionais de enfermagem durante a pandemia da covid-19
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Santos, Katarina Márcia Rodrigues dos

; Galvão, Maria Helena Rodrigues

; Gomes, Sávio Marcelino

; Souza, Talita Araujo de

; Medeiros, Arthur de Almeida

; Barbosa, Isabelle Ribeiro

Escola Anna Nery

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2021, Volume 25 Nº spe elocation e20200370

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Analisar a prevalência de sintomas depressão, ansiedade e fatores associados em profissionais da equipe de enfermagem durante a pandemia da Covid-19. Métodos Estudo seccional do tipo web survey, com 490 com profissionais de enfermagem dos serviços de média e alta complexidade em um estado do nordeste do Brasil. A associação entre os desfechos e as variáveis independentes foi através do teste de qui-quadrado de Rao-Scott e do modelo de regressão de Poisson. Resultados A ocorrência de sintomas sugestivos de transtornos mentais (ansiedade e depressão) estava relacionada a profissionais de enfermagem do sexo feminino, cor ou raça parda, com renda mensal inferior a 5 salários mínimos que trabalhavam no setor privado, ter sintomas de Síndrome de Burnout e morar com os pais. As ocorrências foram mais acentuadas quando os serviços não apresentavam condições adequadas de trabalho, em especial para o enfrentamento da pandemia de Covid-19. Conclusão e implicações para a prática Ações que visem à melhoria das condições de trabalho e que estimulem a prática de atividades físicas podem ser benéficas para o a manutenção e fortalecimento das condições de saúde mental dessa população.

ABSTRACT Objective To analyze the prevalence of symptoms of depression, anxiety and associated factors in Nursing staff during the Covid-19 pandemic. Method A cross-sectional web survey study, with 490 Nursing professionals from medium and high complexity services in a state in northeastern Brazil. The association between the outcomes and the independent variables was through the Rao-Scott chi-square test and the Poisson regression model. Results The occurrence of symptoms suggestive of mental disorders (anxiety and depression) was related to female Nursing professionals, brown skin color or race, with a monthly income below 5 minimum wages and working in the private sector, having symptoms of the Burnout Syndrome and living with their parents. The occurrences were more accentuated when the services did not have adequate working conditions, especially for coping with the Covid-19 pandemic. Conclusion and implications for the practice Actions that aim to improve the working conditions and that encourage the practice of physical activities can be beneficial for the maintenance and strengthening of the mental health conditions of this population.

RESUMEN Objetivo Analizar la prevalencia de síntomas de depresión, ansiedad y factores asociados en el personal de enfermería durante la pandemia de Covid-19. Métodos Estudio de encuesta web seccional, con 490 profesionales de enfermería de servicios de mediana y alta complejidad en un estado del noreste de Brasil. La asociación entre los resultados y las variables independientes se realizó mediante la prueba de chi-cuadrado de Rao-Scott y el modelo de regresión de Poisson. Resultados La ocurrencia de síntomas sugestivos de trastornos mentales (ansiedad y depresión) se relacionó con mujeres profesionales de enfermería, de color o raza morena, con ingresos mensuales inferiores a 5 salarios mínimos que trabajaban en el sector privado, presentaban síntomas de Síndrome de Burnout y vivían con los padres. Los episodios eran más acentuados cuando los servicios no contaban con las condiciones laborales adecuadas, especialmente para hacer frente a la pandemia Covid-19. Conclusión e implicaciones para la práctica Las acciones que tengan como objetivo mejorar las condiciones laborales y que incentiven la práctica de actividades físicas pueden ser beneficiosas para el mantenimiento y fortalecimiento de las condiciones de salud mental de esta población.

https://doi.org/10.1590/2177-9465-ean-2020-0370 23260 downloads

Depressão e ansiedade em profissionais de enfermagem durante a pandemia da covid-19
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Santos, Katarina Márcia Rodrigues dos

; Galvão, Maria Helena Rodrigues

; Gomes, Sávio Marcelino

; Souza, Talita Araujo de

; Medeiros, Arthur de Almeida

; Barbosa, Isabelle Ribeiro

Escola Anna Nery

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2021, Volume 25 Nº spe elocation e20200370

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/2177-9465-ean-2020-0370 417 downloads

Travestis and transsexual women: who are at higher risk for sexually transmitted infections?
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Santos, Paulie Marcelly Ribeiro dos

; Santos, Kamila Cardoso dos

; Magalhães, Larissa Silva

; Oliveira, Brunna Rodrigues de

; Carneiro, Megmar Aparecida dos Santos

; Souza, Márcia Maria de

; Caetano, Karlla Antonieta Amorim

; Pacheco, Leonora Rezende

; Teles, Sheila Araújo

Revista Brasileira de Epidemiologia

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2021, Volume 24 elocation e210017

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Comparar características sociais, comportamentos de risco e infecções sexualmente transmissíveis entre travestis e mulheres transexuais. Métodos: Estudo transversal conduzido em três cidades de Goiás, Brasil Central. De abril de 2018 a agosto de 2019, foram entrevistadas mulheres trans a respeito de características sociodemográficas, discriminação, preconceito, comportamentos sexuais, drogas ilícitas e testagem prévia para HIV e sífilis. Resultados: Um total de 166 travestis e 249 mulheres transexuais foram investigadas. Embora as violências sexual, física e verbal fossem comuns para ambos os grupos, comportamentos sexuais, uso de drogas ilícitas, prisão e teste positivo para HIV e sífilis foram mais frequentes entre as travestis quando comparadas às mulheres transexuais. Conclusão: Os presentes resultados ratificam que as travestis brasileiras apresentam maior risco para infecções sexualmente transmissíveis (IST); portanto, os gestores de saúde devem levar em conta esse desequilíbrio nas propostas de medidas de intervenção em saúde.

ABSTRACT: Objective: To compare social characteristics, risk behaviors, and sexually transmitted infections among travestis and transsexual women. Methodology: A cross-sectional study was carried out in three cities in Goiás, Central Brazil. Trans women were interviewed on sociodemographic characteristics, discrimination, prejudice, sexual behavior, illicit drugs, and previous testing for HIV and syphilis between April 2018 and August 2019. Results: A total of 166 travestis and 249 transsexual women were investigated. Although sexual, physical, and verbal violence were common to both groups, sexual behavior, use of illicit drugs, prison, and previous positive HIV and syphilis testing were more frequent among travestis than in transsexual women. Conclusion: The present findings confirm that Brazilian travestis are at greater risk for sexually transmitted infections (STI), indicating that health services should take this imbalance into account in terms of health intervention proportions.

https://doi.org/10.1590/1980-549720210017

Travestis and transsexual women: who are at higher risk for sexually transmitted infections?
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Santos, Paulie Marcelly Ribeiro dos

; Santos, Kamila Cardoso dos

; Magalhães, Larissa Silva

; Oliveira, Brunna Rodrigues de

; Carneiro, Megmar Aparecida dos Santos

; Souza, Márcia Maria de

; Caetano, Karlla Antonieta Amorim

; Pacheco, Leonora Rezende

; Teles, Sheila Araújo

Revista Brasileira de Epidemiologia

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2021, Volume 24 elocation e210017

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720210017 945 downloads

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 Nº 1 elocation e20200452

Resumo: En | Texto: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

10.

Predominance of Giardia duodenalis AII sub-assemblage in young children from Salvador, Bahia, Brazil
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Figueiredo Pacheco, Flávia Thamiris

; Rodrigues Silva, Renata Kelly Novaes

; Souza de Carvalho, Silvia

; Carvalho Rocha, Felipe

; Trindade das Chagas, Gisele Maria

; Chagas Gomes, Daisy

; da Costa-Ribeiro Junior, Hugo

; Medrado Ribeiro, Tereza Cristina

; Mattos, Ângela Peixoto de

; Kalabric Silva, Luciano

; Soares, Neci Matos

; Aquino Teixeira, Márcia Cristina

Biomédica

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Set 2020, Volume 40 Nº 3 Páginas 557 - 568

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Introducción. Giardia duodenalis es un protozoo intestinal de gran prevalencia en los niños de los países en desarrollo. En estudios moleculares se ha evidenciado la gran diversidad genética de G. duodenalis y se han identificado los conjuntos A y B, principalmente en humanos. A pesar de su importancia, el conocimiento de la epidemiología molecular de la giardiasis humana aún es limitado en Brasil. Objetivo. Caracterizar los aislamientos moleculares de G. duodenalis de muestras tomadas a niños de Salvador, Bahía, Brasil. Materiales y métodos. Las muestras fecales positivas para G. duodenalis se obtuvieron de 71 niños de dos guarderías y de 39 usuarios de un laboratorio de análisis clínicos. Las muestras se analizaron mediante PCR-RFLP de los genes gdh y beta-giardin, y secuenciación de beta-giardin. Resultados. De las 110 muestras de G. duodenalis, en 80 (72,7 %) se amplificaron uno o ambos genes. De estos, 62 (77,5 %) se identificaron como pertenecientes al conjunto A y 18 (22,5 %) al B. El subconjunto AII se identificó en el 58,8 % (n=47) de los aislamientos, seguido del AI en el 18,8% (n=15), el BIV en el 11,2% (n=9) y el BIII en el 5,0% (n=4). El subconjunto AII fue el más frecuente en los niños de ambas guarderías, en tanto que el AI solo se encontró en el grupo atendido en el laboratorio clínico. El subconjunto AII predominó en los niños menores de dos años. Conclusiones. La mayor frecuencia del subconjunto AII sugiere que la transmisión antroponótica es más común en Salvador, pero también existen vías de transmisión zoonóticas, y que pueden ocurrir cambios en la sensibilidad frente a diferentes patrones moleculares de Giardia durante el crecimiento infantil.

Abstract Introduction. Giardia duodenalis is an intestinal protozoan with a high prevalence in children of developing countries. Molecular studies revealed a great genetic diversity of G. duodenalis, with assemblages A and B found mainly in humans. Despite its importance, the information on the molecular epidemiology of human giardiasis is still limited in Brazil. Objective. To characterize G. duodenalis molecular isolates in children from Salvador, Bahia, Brazil. Materials and methods. Giardia duodenalis positive fecal samples were obtained from 71 children from two day care centers and 39 users of a clinical analysis laboratory. Samples were analyzed by PCR-RFLP of the glutamate dehydrogenase (gdh) and beta-giardin genes and by the sequencing of beta-giardin. Results. Of the 110 G. duodenalis samples, 80 (72.7%) amplified one or both target genes. Of these, 62 (77.5 %) were identified as assemblage A and 18 (22.5%) as assemblage B. The subassemblage AII was identified in 58.8% (n=47) of isolates followed by the sub-assemblage AI (18.8%, n=15), BIV (11.2%, n=9), and BIII (5.0%, n=4). The AII sub-assemblage was the most frequent in children of both day care centers whereas AI was found only in the group attended at the clinical laboratory. Sub-assemblage AII predominated in children under two years. Conclusions. The higher frequency of AII sub-assemblage suggests that anthroponotic transmission is more common in Salvador, but that zoonotic transmission pathways are also present and a change in susceptibility to different molecular patterns of Giardia may occur during child growth.

https://doi.org/10.7705/biomedica.5161 296 downloads

11.

Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital
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STUDART-NETO, Adalberto

; GUEDES, Bruno Fukelmann

; TUMA, Raphael de Luca e

; CAMELO FILHO, Antonio Edvan

; KUBOTA, Gabriel Taricani

; IEPSEN, Bruno Diógenes

; MOREIRA, Gabriela Pantaleão

; RODRIGUES, Júlia Chartouni

; FERRARI, Maíra Medeiros Honorato

; CARRA, Rafael Bernhart

; SPERA, Raphael Ribeiro

; OKU, Mariana Hiromi Manoel

; TERRIM, Sara

; LOPES, Cesar Castello Branco

; PASSOS NETO, Carlos Eduardo Borges

; FIORENTINO, Matheus Dalben

; DE SOUZA, Julia Carvalhinho Carlos

; BAIMA, José Pedro Soares

; DA SILVA, Tomás Fraga Ferreira

; MORENO, Cristiane Araujo Martins

; SILVA, Andre Macedo Serafim

; HEISE, Carlos Otto

; MENDONÇA, Rodrigo Holanda

; FORTINI, Ida

; SMID, Jerusa

; ADONI, Tarso

; GONÇALVES, Marcia Rubia Rodrigues

; PEREIRA, Samira Luisa Apóstolos

; PINTO, Lecio Figueira

; GOMES, Helio Rodrigues

; ZANOTELI, Edmar

; BRUCKI, Sonia Maria Dozzi

; CONFORTO, Adriana Bastos

; CASTRO, Luiz Henrique Martins

; NITRINI, Ricardo

Arquivos de Neuro-Psiquiatria

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Ago 2020, Volume 78 Nº 8 Páginas 494 - 500

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Mais de um terço dos pacientes com COVID-19 apresentam sintomas neurológicos que variam de anosmia a AVC e encefalopatia. Além disso, doenças neurológicas prévias podem exigir tratamento especial e estar associadas a piores desfechos. Não obstante, o papel dos neurologistas na COVID-19 é provavelmente pouco reconhecido. Objetivo: O objetivo deste estudo foi relatar os motivos para solicitar consultas neurológicas por clínicos e intensivistas em um hospital dedicado à COVID-19. Métodos: Estudo retrospectivo realizado no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brasil, um centro dedicado à COVID-19 com 900 leitos (incluindo 300 leitos para unidades de terapia intensiva). O diagnóstico de COVID-19 foi confirmado por SARS-CoV-2-RT-PCR em swabs nasais. Todas as interconsultas de neurologia hospitalar entre 23 de março e 23 de maio de 2020 foram analisadas. Os neurologistas realizaram o exame neurológico, avaliaram todos os dados disponíveis para diagnosticar a patologia neurológica e solicitaram exames adicionais conforme necessidade. Diagnósticos difíceis foram estabelecidos em reuniões de consenso. Após o diagnóstico, os neurologistas participaram da condução dos casos. Resultados: Foram solicitadas consultas neurológicas para 89 de 1.208 (7,4%) em pacientes internados por COVID-19 durante o período. Os principais diagnósticos neurológicos incluíram: encefalopatia (44,4%), acidente vascular cerebral (16,7%), doenças neurológicas prévias (9,0%), crises epilépticas (9,0%), transtornos neuromusculares (5,6%), outras lesões encefálicas agudas (3,4%) e outros sintomas leves inespecíficos (11,2%). Conclusões: A maioria das consultas neurológicas em um hospital dedicado à COVID-19 foi solicitada para condições graves que poderiam afetar o desfecho clínico. Os médicos na linha de frente devem ser capazes de reconhecer sintomas neurológicos. Os neurologistas são membros importantes da equipe médica no atendimento hospitalar à COVID-19.

ABSTRACT Background: More than one-third of COVID-19 patients present neurological symptoms ranging from anosmia to stroke and encephalopathy. Furthermore, pre-existing neurological conditions may require special treatment and may be associated with worse outcomes. Notwithstanding, the role of neurologists in COVID-19 is probably underrecognized. Objective: The aim of this study was to report the reasons for requesting neurological consultations by internists and intensivists in a COVID-19-dedicated hospital. Methods: This retrospective study was carried out at Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil, a 900-bed COVID-19 dedicated center (including 300 intensive care unit beds). COVID-19 diagnosis was confirmed by SARS-CoV-2-RT-PCR in nasal swabs. All inpatient neurology consultations between March 23rd and May 23rd, 2020 were analyzed. Neurologists performed the neurological exam, assessed all available data to diagnose the neurological condition, and requested additional tests deemed necessary. Difficult diagnoses were established in consensus meetings. After diagnosis, neurologists were involved in the treatment. Results: Neurological consultations were requested for 89 out of 1,208 (7.4%) inpatient COVID admissions during that period. Main neurological diagnoses included: encephalopathy (44.4%), stroke (16.7%), previous neurological diseases (9.0%), seizures (9.0%), neuromuscular disorders (5.6%), other acute brain lesions (3.4%), and other mild nonspecific symptoms (11.2%). Conclusions: Most neurological consultations in a COVID-19-dedicated hospital were requested for severe conditions that could have an impact on the outcome. First-line doctors should be able to recognize neurological symptoms; neurologists are important members of the medical team in COVID-19 hospital care.

https://doi.org/10.1590/0004-282x20200089 2651 downloads

12.

[SciELO Preprints] - Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital
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Studart-Neto, Adalberto Guedes, Bruno Fukelmann Tuma, Raphael De Luca E Camelo Filho, Antonio Edvan Kubota, Gabriel Taricani Iepsen, Bruno Diógenes Moreira, Gabriela Pantaleão Rodrigues, Júlia Chartouni Ferrari, Maíra Medeiros Honorato Carra, Rafael Bernhard Spera, Raphael Ribeiro Oku, Mariana Hiromi Manoel Terrim, Sara Lopes, Cesar Castello Branco Passos Neto, Carlos Eduardo Borges Dalben, Matheus De Souza, Julia Carvalhinho Carlos Baima, José Pedro Soares Da Silva, Tomás Fraga Ferreira Moreno, Cristiane Araujo Martins Silva, Andre Macedo Serafim Heise, Carlos Otto Mendonça, Rodrigo Holanda Fortini, Ida Smid, Jerusa Adoni, Tarso Gonçalves, Marcia Rubia Rodrigues Pereira, Samira Luisa Apóstolos Pinto, Lecio Figueira Gomes, Helio Rodrigues Zanotelli, Edmar Brucki, Sonia Maria Dozzi Conforto, Adriana Bastos Castro, Luiz Henrique Martins Nitrini, Ricardo

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Data de publicação: 2020-07-16

Resumo: En Pt

Background: More than one-third of COVID-19 patients present neurological symptomsranging from anosmia to stroke and encephalopathy. Furthermore, pre-existingneurological conditions may require special treatment and may be associated with worseoutcomes. Notwithstanding, the role of neurologists in COVID-19 is probablyunderrecognized. Objective: The aim of this study was to report the reasons forrequesting neurological consultations by internists and intensivists in a COVID-19-dedicated hospital. Methods: This retrospective study was carried out at Hospital dasClínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil, a 900-bedCOVID-19 dedicated center (including 300 intensive care unit beds). COVID-19 diagnosiswas confirmed by SARS-CoV-2-RT-PCR in nasal swabs. All inpatient neurologyconsultations between March 23rd and May 23rd, 2020 were analyzed. Neurologistsperformed the neurological exam, assessed all available data to diagnose theneurological condition, and requested additional tests deemed necessary. Difficultdiagnoses were established in consensus meetings. After diagnosis, neurologists wereinvolved in the treatment. Results: Neurological consultations were requested for 89 outof 1,208 (7.4%) inpatient COVID admissions during that period. Main neurologicaldiagnoses included: encephalopathy (44.4%), stroke (16.7%), previous neurologicaldiseases (9.0%), seizures (9.0%), neuromuscular disorders (5.6%), other acute brainlesions (3.4%), and other mild nonspecific symptoms (11.2%). Conclusions: Mostneurological consultations in a COVID-19-dedicated hospital were requested for severeconditions that could have an impact on the outcome. First-line doctors should be able torecognize neurological symptoms; neurologists are important members of the medicalteam in COVID-19 hospital care.

Introdução: Mais de um terço dos pacientes com COVID-19 apresentam sintomasneurológicos que variam de anosmia a AVC e encefalopatia. Além disso, doençasneurológicas prévias podem exigir tratamento especial e estar associadas a pioresdesfechos. Não obstante, o papel dos neurologistas na COVID-19 é provavelmentepouco reconhecido. Objetivo: O objetivo deste estudo foi relatar os motivos para solicitarconsultas neurológicas por clínicos e intensivistas em um hospital dedicado à COVID-19. Métodos: Estudo retrospectivo realizado no Hospital das Clínicas da Faculdade deMedicina da Universidade de São Paulo, Brasil, um centro dedicado à COVID-19 com900 leitos (incluindo 300 leitos para unidades de terapia intensiva). O diagnóstico deCOVID-19 foi confirmado por SARS-CoV-2-RT-PCR em swabs nasais. Todas asinterconsultas de neurologia hospitalar entre 23 de março e 23 de maio de 2020 foramanalisadas. Os neurologistas realizaram o exame neurológico, avaliaram todos os dadosdisponíveis para diagnosticar a patologia neurológica e solicitaram exames adicionaisconforme necessidade. Diagnósticos difíceis foram estabelecidos em reuniões deconsenso. Após o diagnóstico, os neurologistas participaram da condução dos casos.Resultados: Foram solicitadas consultas neurológicas para 89 de 1.208 (7,4%) empacientes internados por COVID-19 durante o período. Os principais diagnósticosneurológicos incluíram: encefalopatia (44,4%), acidente vascular cerebral (16,7%),doenças neurológicas prévias (9,0%), crises epilépticas (9,0%), transtornosneuromusculares (5,6%), outras lesões encefálicas agudas (3,4%) e outros sintomasleves inespecíficos (11,2%). Conclusões: A maioria das consultas neurológicas em umhospital dedicado à COVID-19 foi solicitada para condições graves que poderiam afetaro desfecho clínico. Os médicos na linha de frente devem ser capazes de reconhecersintomas neurológicos. Os neurologistas são membros importantes da equipe médica noatendimento hospitalar à COVID-19.

https://doi.org/10.1590/0004-282X20200089

13.

Exercise tests in Chagas cardiomyopathy: an overview of functional evaluation, prognostic significance, and current challenges
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Costa, Henrique Silveira

; Lima, Márcia Maria Oliveira

; Figueiredo, Pedro Henrique Scheidt

; Lima, Vanessa Pereira

; Ávila, Matheus Ribeiro

; Menezes, Kenia Kiefer Parreiras de

; Mendonça, Vanessa Amaral

; Lacerda, Ana Cristina Rodrigues

; Nunes, Maria Carmo Pereira

; Mediano, Mauro Felippe Felix

; Rocha, Manoel Otávio da Costa

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20200100

Resumo: En | Texto: En | PDF: En

Abstract Patients with Chagas cardiomyopathy (ChC) usually progress with fatigue and dyspnea. Exercise tests are valuable for the functional evaluation of these patients. However, information about the applicability of the exercise tests is scattered, and no studies have systematically reviewed the results. Thus, the present review explored the general aspects and prognostic value of exercise tests in patients with ChC. A literature search of the MEDLINE, Web of Science, CINAHL, Scopus, and LILACS databases was performed to identify relevant studies. There were no data restrictions, and articles that met the objective of the study were selected. Articles written in English, Portuguese, and Spanish were considered, and 25 articles were finally included. The peak oxygen uptake (VO2peak) was correlated with demographic and echocardiographic variables. Echocardiographic features of the left ventricular diastolic function and right ventricular systolic function appeared to be determinants of functional capacity, in addition to age and sex. VO2peak was associated with higher mortality, especially in patients with dilated ChC. The minute ventilation/carbon dioxide production slope (VE/VCO2 slope) was a strong predictor of survival; however, more studies are needed to verify this observation. Field tests showed moderate to strong correlation with VO2peak and thus may be inexpensive tools for the functional evaluation of patients with ChC. However, few studies have verified their prognostic significance. While exercise tests are useful tools for functional assessment, information is scarce regarding further considerations, and many of the criteria are based on guidelines for other heart diseases.

https://doi.org/10.1590/0037-8682-0100-2020 1043 downloads

14.

Charing Cross Venous Ulcer Questionnaire - Brasil: estudo bicêntrico de confiabilidade
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Amaral, Kelle Vanessa Alvares

; Melo, Paulla Guimarães

; Alves, Gabriela Rodrigues

; Soriano, José Verdú

; Ribeiro, Andrea Pinto Leite

; Oliveira, Beatriz Guitton Renaud Baptista de

; Bachion, Maria Márcia

Acta Paulista de Enfermagem

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Abr 2019, Volume 32 Nº 2 Páginas 147 - 152

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective To verify the internal consistency and stability of the Charing Cross Venous Ulcer Questionnaire - Brazil (CCVUQ-Brazil). Methods This was a methodological study conducted in two cities from different regions of Brazil (Goiania and Niteroi), from June 2016 to June 2018. The sample for internal consistency was composed of 112 individuals and for stability 74 participants were evaluated. All the individuals presented with a venous ulcer and received care in the public health network. For internal consistency analysis the Cronbach's alpha was calculated. The questionnaire was administered twice with a 30 minutes interval and for the stability analysis the intraclass correlation coefficient (ICC) was calculated. Results The CCVUQ-Brazil presented a Cronbach's alpha score of 0.92, and for the domains (social interaction, domestic activities, aesthetics and emotional state) it was above 0.70. The stability was excellent (ICC = 0.96) for total score of the questionnaire and for the majority of the domains. Conclusion The CCVUQ- Brazil showed good internal consistency, considering the two locations analyzed, and excellent stability in the Goiania.

Resumen Objetivo: Verificar la consistencia interna y estabilidad del Charing Cross Venous Ulcer Questionnaire - Brasil (CCVUQ-Brasil). Métodos: Se trata de una investigación metodológica realizada en dos regiones de Brasil (Goiânia y Niterói), en el período de junio de 2016 a junio de 2018. La muestra para la consistencia interna fue compuesta por 112 personas y, para la estabilidad, 74 pacientes fueron estudiados, todos con úlcera venosa atendidos en la red pública de salud. Para analizar la consistencia interna se calculó el alfa de Cronbach. Para la estabilidad, se aplicó el cuestionario dos veces con un intervalo de 30 minutos y para analizarlo se calculó el coeficiente de correlación intraclase (CCI). Resultados: El CCVUQ-Brasil presentó alfa de Cronbach igual a 0,92 en la puntuación total del cuestionario y en los dominios (interacción social, actividades domésticas, estética y estado emocional) fue superior a 0,70. La estabilidad fue excelente (CCI=0,96) en la puntuación total del cuestionario y en la mayoría de los dominios. Conclusión: El CCVUQ - Brasil obtuvo una buena consistencia interna considerando los dos escenarios estudiados y una excelente estabilidad en el escenario Goiânia.

Resumo Objetivo: Verificar a consistência interna e estabilidade do Charing Cross Venous Ulcer Questionnaire - Brasil (CCVUQ-Brasil). Métodos: Trata-se de uma pesquisa metodológica realizada em duas regiões do Brasil (Goiânia e Niterói), no período de junho de 2016 a junho de 2018. A amostra para a consistência interna foi composta por 112 pessoas e para a estabilidade foram avaliados 74 participantes, todos com úlcera venosa atendidas na rede pública de saúde. Para análise da consistência interna foi calculado o alfa de Cronbach. Para estabilidade, o questionário foi aplicado duas vezes com intervalo de 30 minutos e para sua análise foi calculado o coeficiente de correlação intraclasse (CCI). Resultados: O CCVUQ-Brasil apresentou alfa de Cronbach para pontuação total do questionário igual 0,92 e para os domínios (interação social, atividades domésticas, estética e estado emocional) foi acima de 0,70. A estabilidade foi excelente (CCI=0,96) para pontuação total do questionário e para a maioria dos domínios. Conclusão: O CCVUQ - Brasil obteve boa consistência interna considerando os dois cenários estudados e excelente estabilidade no cenário Goiânia.

https://doi.org/10.1590/1982-0194201900021 65 downloads

15.

Charing Cross Venous Ulcer Questionnaire - Brasil: estudo bicêntrico de confiabilidade
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Amaral, Kelle Vanessa Alvares

; Melo, Paulla Guimarães

; Alves, Gabriela Rodrigues

; Soriano, José Verdú

; Ribeiro, Andrea Pinto Leite

; Oliveira, Beatriz Guitton Renaud Baptista de

; Bachion, Maria Márcia

Acta Paulista de Enfermagem

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Mar 2019, Volume 32 Nº 2 Páginas 147 - 152

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/1982-0194201900021 1264 downloads

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