Pesquisa | SciELO

Resumen Objetivo Analizar las evidencias de validez de contenido y proceso de respuesta de un banco de ítems sobre vulnerabilidad en salud. Métodos Estudio psicométrico, fundamentado por el polo teórico de Pasquali. Se seleccionaron 62 especialistas con características sociodemográficas y académicas diferentes. Entre ellos, 15 respondieron al cuestionario de validez de contenido. Después de las adaptaciones, el banco pasó a la fase de validez del proceso de respuesta y fue evaluado por 12 usuarios de los servicios de salud. Se utilizó el coeficiente de validez de contenido para evaluar los ítems y el banco, cuya fiabilidad ser verificó mediante la prueba binominal, que consideró un porcentaje de 80 y p-valor >0,05. Resultados El banco presentó buena evidencia de validez de contenido por los especialistas, cuyos coeficientes fueron 0,87 en el elemento sujeto, 0,86 en el elemento social y 0,865 en el general. El público destinatario realizó sugerencias en la fase de validez del proceso de respuesta para una mejor comprensión de los ítems (coeficiente total: 0,89) y fue considerado claro, preciso y comprensible. Conclusión La versión final del banco de ítems contiene 535 ítems, de los cuales 238 son para el sujeto y 297 para el social. Presenta indicios de evidencia de validez de contenido y proceso de respuesta y está apto para una prueba de validez de estructura interna. salud psicométrico Pasquali 6 diferentes ellos 1 adaptaciones binominal 8 pvalor p valor 005 0 05 >0,05 087 87 0,8 086 86 0865 865 general total 0,89 089 89 claro comprensible 53 23 29 interna 00 >0,0 08 0, 5 2 >0, >0 >

Abstract Objective To analyze the evidence of content validity and response process of a health vulnerability item bank. Methods Psychometric study with support of Pasquali’s theoretical pole in which 62 specialists with different sociodemographic and academic characteristics were selected and 15 of them responded to the content validity questionnaire. After adjustments, the bank moved to the response process validity phase and was evaluated by 12 health service users. A content validity coefficient was used to evaluate the items and the bank, which had the reliability assessed by the binomial test, considering a percentage of 80% and p-value >0.05. Results The bank presented good evidence of content validity by experts. The coefficients were 0.87 for the subject element, 0.86 for the social element and 0.865 for the general element. The target audience made suggestions in the response process validity phase to better understand the items (total coefficient: 0.89), which were considered clear, accurate and understandable. Conclusion The final version of the item bank has 535 items, 238 for the subject and 297 for the social element. It presents evidence of validity of content and response process and is suitable for testing the validity of internal structure. Pasqualis Pasquali s 6 1 questionnaire adjustments users test 80 pvalue p value 005 0 05 >0.05 experts 087 87 0.8 086 86 0865 865 total 0.89, 089 0.89 , 89 0.89) clear understandable 53 23 29 structure 8 00 >0.0 08 0. 5 2 >0. >0 >

Resumo Objetivo Analisar as evidências de validade de conteúdo e processo de resposta de um banco de itens sobre vulnerabilidade em saúde. Métodos Estudo psicométrico, subsidiado pelo polo teórico de Pasquali. Foram selecionados 62 especialistas com características sociodemográficas e acadêmicas distintas. Desses, 15 responderam ao questionário de validade de conteúdo. Após os ajustes, o banco passou para fase de validade de processo de resposta e foi avaliado por 12 usuários dos serviços de saúde. Utilizou-se coeficiente de validade de conteúdo para avaliação dos itens e do banco, cuja confiabilidade foi verificada pelo teste binomial, considerando percentual de 80% e p-valor >0,05. Resultados O banco apresentou boa evidência de validade de conteúdo pelos especialistas, cujos coeficientes foram 0,87 para o elemento sujeito, 0,86 para o elemento social e 0,865 para o geral. O público-alvo realizou sugestões na fase de validade de processo de resposta para melhor compreensão dos itens (coeficiente total: 0,89), sendo considerado, claro, preciso e compreensível. Conclusão A versão final do banco de itens possui 535 itens, sendo 238 para o sujeito e 297 para o social. Apresenta indícios de evidência de validade de conteúdo e processo de resposta e está apto para testagem de validade de estrutura interna. saúde psicométrico Pasquali 6 distintas Desses 1 ajustes Utilizouse Utilizou se binomial 80 pvalor p valor 005 0 05 >0,05 087 87 0,8 086 86 0865 865 geral públicoalvo público alvo total 0,89, 089 0,89 , 89 0,89) considerado claro compreensível 53 23 29 interna 8 00 >0,0 08 0, 5 2 >0, >0 >

https://doi.org/10.37689/acta-ape/2024ao0000602

Thyroid surgery volume – A statement issued by the Brazilian Head and Neck Surgery Society (SBCCP) SBCCP (SBCCP
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Matos, Fatima Cristina Mendes de

; Vartanian, José Guilherme

; Barauna Neto, José Carlos

; Santos, Ary Serrano

; Machado, Achilles Alves de Levy

; Pedruzzi, Paola Andrea Galbiatti

; Neves, Murilo Catafesta das

; Hojaij, Flavio Carneiro

; Nakai, Marianne Yumi

; Viana, Aline de Oliveira Ribeiro

; Santos, Izabella Costa

; de Cicco, Rafael

; Capuzzo, Renato de Castro

; Capelli, Fábio de Aquino

; De Carlucci Junior, Dorival

; Teixeira, Gilberto Vaz

; Cavalheiro, Beatriz

; Brodskin, Fabio

; Agra, Ivan

; Dias, Fernando Luiz

; Kulcsar, Marco Aurélio

; de Melo, Giulianno Molina

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e240064

Resumo: En | Texto: En | PDF: En

https://doi.org/10.20945/2359-4292-2024-0064

Um breve panorama sobre a Agenda 2030, as doenças crônicas não transmissíveis e os desafios de não deixar ninguém para trás 2030 203 20 2
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Pires, Laurenice de Jesus Alves

; Ribeiro, José Mendes

; Cruz, Marly Marques da

Cadernos de Saúde Pública

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2024, Volume 40 Nº 7 elocation e00139323

Resumo: Es Pt En | Texto: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen: Este ensayo aporta una reflexión teórica acerca de los desafíos para lograr las metas de los Objetivos de Desarrollo Sostenible de la Agenda 2030, teniendo en cuenta su lema “no dejar a nadie atrás”. Para ejemplificar estos desafíos, tomamos como telón de fondo las enfermedades crónicas no transmisibles (ECNT), uno de los principales temas de la agenda de salud global antes de la pandemia de COVID-19, discutiendo las dimensiones políticas y económicas que determinan su presencia y avance global. Después de un breve panorama de las ECNT, el texto busca responder tres preguntas: En “¿Sin dejar a nadie atrás?” enumeramos algunos temas para reflexionar sobre cómo y quién ha quedado históricamente atrás, profundizando un poco más los ejemplos al centrarse en “¿Quién ha quedado atrás en el mundo?” y “¿Quién ha quedado atrás en Brasil?”. Con base en datos de la literatura más relevante y reciente sobre el tema, presentamos los desafíos y algunas maneras de no dejar a nadie atrás en un mundo en el que el modo de producción ha vulnerabilizado históricamente a algunos grupos sociales, con énfasis en la población negra y en la población indígena. En nuestras consideraciones finales, nos inspiramos en el ideograma de Sankofa para recordar que las respuestas al desarrollo sostenible que buscamos pueden estar en algún lugar de nuestro pasado más original y tradicional. Y es necesario apostar por la construcción de nuevos caminos basados en otras epistemologías y cosmovisiones presentes al otro lado de la línea abisal. Resumen 2030 atrás. . atrás” ECNT , (ECNT) COVID19, COVID19 COVID 19, 19 COVID-19 preguntas ¿Sin Sin atrás? ¿Quién Quién mundo? Brasil. Brasil Brasil?” tema sociales indígena finales tradicional abisal 203 (ECNT COVID1 1 COVID-1 Brasil? 20 COVID- 2

Resumo: Este ensaio traz uma reflexão teórica sobre os desafios para alcançar as metas dos Objetivos do Desenvolvimento Sustentável da Agenda 2030, considerando seu lema de “não deixar ninguém para trás”. Para exemplificar esses desafios, apresenta-se como pano de fundo as doenças crônicas não transmissíveis (DCNT), um dos principais temas da agenda da saúde global antes da pandemia de COVID-19, discutindo as dimensões políticas e econômicas que determinam sua presença e avanço global. Após um breve panorama sobre as DCNT, busca-se responder a três perguntas: em “Sem deixar ninguém para trás?”, elencamos alguns temas para refletir sobre como e quem tem ficado historicamente para trás, aprofundando um pouco mais os exemplos ao adentrar em “Quem tem ficado para trás no mundo?” e “Quem tem ficado para trás no Brasil?”. A partir de dados da literatura mais relevante e recente sobre o tema, apresentamos os desafios e alguns caminhos para não deixar ninguém para trás em um mundo em que o modo de produção tem historicamente vulnerabilizado alguns grupos sociais, com destaque para a população negra e a população indígena. Trazemos nas considerações finais a inspiração do ideograma Sankofa para lembrar que as respostas para o desenvolvimento sustentável que buscamos podem estar em algum lugar de nosso passado mais originário e tradicional, e que é preciso apostar na construção de novos caminhos a partir de outras epistemologias e cosmovisões presentes do outro lado da linha abissal. Resumo 2030 trás. . trás” apresentase apresenta se DCNT , (DCNT) COVID19, COVID19 COVID 19, 19 COVID-19 buscase busca perguntas Sem trás?” Quem mundo? Brasil. Brasil Brasil?” tema sociais indígena tradicional abissal 203 (DCNT COVID1 1 COVID-1 trás? Brasil? 20 COVID- 2

Abstract: This essay provides a theoretical reflection on the challenges of meeting the Sustainable Development Goals of the 2030 Agenda, considering its motto of “leave no one behind”. To exemplify these challenges, we discuss noncommunicable diseases (NCDs), one of the main issues on the global health agenda before the COVID-19 pandemic, and the political and economic dimensions that determine their presence and global spread. After a brief overview of NCDs, the text seeks to answer three questions: In “Leaving no one behind?” we list some themes to reflect on how and who has historically been left behind, delving a little deeper into the examples in “Who has been left behind in the world?” and “Who has been left behind in Brazil?”. Using data from the most relevant and recent literature on the subject, we discuss the challenges and some ways to leave no one behind in a world where the mean of production has historically made some social groups vulnerable, especially black and Indigenous populations. In our final remarks, we draw inspiration from the Sankofa ideogram to remember that the answers to the sustainable development we seek may lie somewhere in our most primordial and traditional past. And that it is necessary to invest on building new paths from different worldviews and approaches to epistemology on the other side of the abyssal line. Abstract 203 Agenda behind. . behind” NCDs , (NCDs) COVID19 COVID 19 COVID-1 pandemic spread questions Leaving behind? Who world? Brazil. Brazil Brazil?” subject vulnerable populations remarks past line 20 (NCDs COVID1 1 COVID- Brazil? 2

https://doi.org/10.1590/0102-311xpt139323

Um breve panorama sobre a Agenda 2030, as doenças crônicas não transmissíveis e os desafios de não deixar ninguém para trás
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Pires, Laurenice de Jesus Alves

; Ribeiro, José Mendes

; Cruz, Marly Marques da

Cadernos de Saúde Pública

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2024, Volume 40 Nº 7 elocation e00139323

Resumo: Es Pt En | Texto: Es Pt En | PDF: Es | PDF: Pt | PDF: En

https://doi.org/10.1590/0102-311xpt139323

Ensino de bioética em pós-graduações na área de medicina III pósgraduações pós graduações
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Cantão, Jackson Luís Ferreira

; Santos, Caroline Mendes

; Gallotte, Juliano Cordeiro

; Ramos, Isaac Prado

; Ribeiro, Edicarla Torres

; Paula, Silma Sousa de

; Vale Júnior, Ademilson Teles do

; Santos, Catarine Mendes

; Silva, José Antônio Cordero da

Revista Bioética

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2024, Volume 32 elocation e3685PT

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

Abstract The objective of this article is to examine how ethics/bioethics teaching is included in the curricula of stricto sensu graduate programs in the field of medicine III, according to the classification of the Coordination for the Improvement of Higher Education Personnel, in the North and Northeast regions of Brazil. This is a documentary, descriptive and exploratory study, of a qualitative and quantitative nature. The Sucupira Platform was used to search for the following information about the programs: state, institution, name of the program, category (academic/professional), score, compulsoriness and name of the course, workload and website of the program. We found nine programs in the field of medicine III, mainly professional master’s degree programs, most of which offer ethics-related courses as compulsory courses. We found that ethics/ bioethics-related courses are present in all programs, although with different workloads. Further studies are necessary in order to research the methodological approaches to ethics teaching in programs in the field. ethicsbioethics bioethics III Personnel Brazil documentary study nature state institution program academic/professional, academicprofessional academic/professional , academic (academic/professional) score course masters master s ethicsrelated related bioethicsrelated workloads (academic/professional

Resumo O objetivo deste artigo é verificar como o ensino de ética/bioética está inserido nas grades curriculares dos programas de pós-graduação stricto sensu na área medicina III, conforme classificação da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, nas regiões Norte e Nordeste. Trata-se de estudo documental, descritivo e exploratório, de natureza qualiquantitativa. Utilizou-se a Plataforma Sucupira para buscar as seguintes informações sobre os programas: estado, instituição, nome do programa, categoria (acadêmico/profissional), nota, obrigatoriedade e nome da disciplina, carga horária e site do programa. Foram encontrados nove programas na área medicina III, sobretudo mestrados profissionais, e a maioria deles oferece disciplinas ligadas a ética como obrigatórias. Verificou-se que disciplinas ligadas a ética/ bioética estão presentes em todos os programas, embora com diferentes cargas horárias. São necessários estudos futuros que investiguem as abordagens metodológicas para ensino de ética nos cursos da área. éticabioética pósgraduação pós graduação III Superior Nordeste Tratase Trata se documental exploratório qualiquantitativa Utilizouse Utilizou estado instituição programa acadêmico/profissional, acadêmicoprofissional acadêmico/profissional , acadêmico profissional (acadêmico/profissional) nota disciplina profissionais obrigatórias Verificouse Verificou horárias (acadêmico/profissional

Resumen El objetivo de este artículo es comprobar la manera en que se incluye la enseñanza de la ética/bioética en los planes de estudio de los programas de posgrado stricto sensu en el campo de la medicina III, según la clasificación de la Coordinación de Perfeccionamiento de Personal de Nivel Superior, en las regiones Norte y Nordeste. Se trata de un estudio documental, descriptivo y exploratorio, de carácter cualicuantitativo. Se utilizó la Plataforma Sucupira para buscar la siguiente información sobre los programas: estado, institución, nombre del programa, categoría (académico/profesional), nota, obligatoriedad y nombre de la asignatura, horas lectivas y página web del programa. Se encontraron nueve programas en el campo de medicina III, sobre todo de másteres profesionales, y la mayoría ofrece asignaturas relacionadas con la ética con carácter obligatorio. Se constató que las asignaturas relacionadas con la ética/bioética están presentes en todos los programas, aunque con diferentes horas lectivas. Se requieren estudios futuros para investigar los enfoques metodológicos para la enseñanza de la ética en cursos de este ámbito. éticabioética bioética III Superior Nordeste documental exploratorio cualicuantitativo estado institución programa académico/profesional, académicoprofesional académico/profesional , académico profesional (académico/profesional) nota asignatura profesionales obligatorio ámbito (académico/profesional

https://doi.org/10.1590/1983-803420243685pt

First isolation and characterization of caprine oviduct fluid extracellular vesicles
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Mendes Júnior, Roberto

; Alcântara Neto, Agostinho Soares de

; Tetaping, Gildas Mbemya

; Novaes, Marco Aurélio Schiavo

; Gonçalves, Vanessa Barbosa Pinheiro

; Silva Neto, João Xavier da

; Almeida, José Jonathas Albuquerque de

; Guedes, Maria Izabel Florindo

; Leal, Luzia Kalyne Almeida Moreira

; Souza-Fabjan, Joanna Maria Gonçalves

; Nicolete, Roberto

; Padilha, Deborah de Melo Magalhães

; Figueiredo, José Ricardo de

; Rodrigues, Ana Paula Ribeiro

Animal Reproduction

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2024, Volume 21 Nº 4 elocation e20240039

Resumo: En | Texto: En | PDF: En

Abstract Oviduct fluid extracellular vesicles (oEV) are essential for periconceptional events. The presence of EV has already been identified in the oviduct fluid (OF) from mammalian species, except in caprine. Therefore, this study aimed to isolate and characterize the caprine oEV (coEV). Initially, in Experiment 1, coEV were isolated from the OF of either each animal individually or from a pool of three animals. In experiment 2, coEV were isolated during the follicular or luteal phases of the estrous cycle. The coEV were characterized by size distribution, polydispersity index (PDI), and zeta potential using dynamic light scattering (DLS) analysis, as well as, by transmission electron microscopy (TEM) and dot blotting (DB). Our results indicated that the physicochemical characteristics of the coEV were similar (P > 0.05), regardless of the isolation method (individual or pool). However, coEV collected during the luteal phase were larger (P < 0.05) than those during the follicular phase. The TEM showed spherical and cup-shaped particles, characteristic of exosomes. The DB revealed the presence of exosomal proteins involved in the biogenesis of coEV. In conclusion, it is possible to isolate and characterize coEV from a single caprine female and the estrous cycle phase influences the vesicles average size and PDI. (oEV events (OF species Therefore . (coEV) Initially 1 animals 2 distribution PDI, PDI , (PDI) DLS (DLS analysis (TEM DB. (DB) P 0.05, 005 0.05 0 05 individual pool. pool) However cupshaped cup shaped particles exosomes conclusion (coEV (PDI (DB 00 0.0 0.

https://doi.org/10.1590/1984-3143-ar2024-0039

Metabolic effect of low fluoride levels in the islets of NOD mice: integrative morphological, immunohistochemical, and proteomic analyses mice morphological immunohistochemical
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TREVIZOL, Juliana Sanches

; DIONIZIO, Aline

; DELGADO, Aislan Quintiliano

; VENTURA, Talita Mendes Oliveira

; RIBEIRO, Caroline Fernanda da Silva

; RIBEIRO, Laura

; BUZALAF, Nathalia Rabelo

; CESTARI, Tânia Mary

; MAGALHÃES, Ana Carolina

; SUZUKI, Maiko

; BOSQUEIRO, José Roberto

; BUZALAF, Marília Afonso Rabelo

Journal of Applied Oral Science

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2023, Volume 31 elocation e20230036

Resumo: En | Texto: En | PDF: En

Abstract Fluoride (F) has been widely used to control dental caries, and studies suggest beneficial effects against diabetes when a low dose of F is added to the drinking water (10 mgF/L). Objectives This study evaluated metabolic changes in pancreatic islets of NOD mice exposed to low doses of F and the main pathways altered by the treatment. Methodology In total, 42 female NOD mice were randomly divided into two groups, considering the concentration of F administered in the drinking water for 14 weeks: 0 or 10 mgF/L. After the experimental period, the pancreas was collected for morphological and immunohistochemical analysis, and the islets for proteomic analysis. Results In the morphological and immunohistochemical analysis, no significant differences were found in the percentage of cells labelled for insulin, glucagon, and acetylated histone H3, although the treated group had higher percentages than the control group. Moreover, no significant differences were found for the mean percentages of pancreatic areas occupied by islets and for the pancreatic inflammatory infiltrate between the control and treated groups. Proteomic analysis showed large increases in histones H3 and, to a lesser extent, in histone acetyltransferases, concomitant with a decrease in enzymes involved in the formation of acetyl-CoA, besides many changes in proteins involved in several metabolic pathways, especially energy metabolism. The conjunction analysis of these data showed an attempt by the organism to maintain protein synthesis in the islets, even with the dramatic changes in energy metabolism. Conclusion Our data suggests epigenetic alterations in the islets of NOD mice exposed to F levels comparable to those found in public supply water consumed by humans. (F caries (1 mgFL mgF/L . mgF L mgF/L) treatment total 4 groups 1 weeks period insulin glucagon H Moreover extent acetyltransferases acetylCoA, acetylCoA acetyl CoA, CoA acetyl-CoA metabolism humans (

https://doi.org/10.1590/1678-7757-2023-0036

Spermine decreases ethylene and increases sugars and phenolic compounds in nasturtium flowers grown under drought and salt stress
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Silva, Toshik Iarley da

; Dias, Marlon Gomes

; Barbosa, Lucas Bretas

; Araújo, Nícolas Oliveira de

; Ferreira, Felipe Douglas

; Grossi, José Antônio Saraiva

; Costa, Franciscleudo Bezerra da

; Marco, Cláudia Araújo

; Ribeiro, Dimas Mendes

Bragantia

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2023, Volume 82 elocation e20230041

Resumo: En | Texto: En | PDF: En

ABSTRACT Nasturtium (Tropaeolum majus) is an ornamental and medicinal plant that has edible flowers. Drought and salt stress decrease flower production and quality, including affecting sugar metabolism and ethylene production. Ethylene can accelerate the nasturtium senescence process, decreasing its postharvest quality. The use of polyamines, mainly spermine, may be a strategy for reducing the harmful effects of these stresses on the metabolism of sugars and phenolic compounds and for decreasing the production of ethylene, which accelerates senescence, in nasturtium flowers. Therefore, the objective here was to evaluate the role of spermine application on sugar and phenolic compounds and on ethylene production in nasturtium flowers grown under drought and salt stress. Two experiments were performed in isolation and at the same time in order to achieve this. Spermine down-regulated ethylene production and up-regulated the content of sugars and phenolic compounds on nasturtium flowers grown under drought and saline stress. Sugars and phenolic compounds down-regulated ethylene production in nasturtium flowers. Spermine can be used to mitigate the harmful effects of drought and salt stress on nasturtium flowers by increasing sugar and phenolic compounds and decreasing ethylene production. Tropaeolum majus quality process polyamines Therefore this downregulated down regulated upregulated up

https://doi.org/10.1590/1678-4499.20230041

Effects of chronic restraint stress in the prostate of prepubertal and adult rats
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Procópio, Isabella Mendes

; Ribeiro, Carina Teixeira

; Marchon, Roger Gaspar

; Costa, Waldemar Silva

; Buys-Gonçalves, Gabriela Faria

; Sampaio, Francisco José Barcellos

; Pereira-Sampaio, Marco Aurélio

; Souza, Diogo Benchimol de

Acta Cirúrgica Brasileira

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2023, Volume 38 elocation e387123

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: To investigate the effects of chronic stress in the prostate of prepubertal and adult rats. Methods: Thirty-two male rats were assigned into four groups depending on the type of treatment (control or stressed) and the age at which stress was initiated (prepubertal or adult). Restraint stress stimuli were applied for six weeks. Stressed prepubertal and adult rats evaluated immediately after the last stress stimuli were named SP and SA groups, respectively. Age-matched rats were used as control groups (CP and CA). At the end of the experiment, the rats were euthanized, and prostate morphological parameters were evaluated and statistically compared. Results: Application of stress stimuli to the SP group resulted in reduced body weight, but no prostate morphological modification was noted. The SA group showed reduced testosterone level and prostatic epithelium surface density, in comparison to CA group. Further, the prostatic lumen surface density was increased in adult stressed animals, in comparison to adult controls. Conclusions: The stress stimuli promoted changes in hormonal and morphological parameters in the prostate of adult stressed rats. Prepubertal stressed animals did not presented modifications of prostate morphology. Purpose Methods Thirtytwo Thirty two adult. . adult) weeks respectively Agematched Age matched CP CA. CA) experiment euthanized compared Results weight noted Further controls Conclusions morphology

https://doi.org/10.1590/acb387123

10.

Contribution of public oral pathology services to the diagnosis of oral and oropharyngeal cancer in Brazil
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LOUREDO, Brendo Vinicius Rodrigues

; CURADO, Maria Paula

; PENAFORT, Paulo Victor Mendes

; DE ARRUDA, José Alcides Almeida

; ABREU, Lucas Guimarães

; MESQUITA, Ricardo Alves

; PINTO-JÚNIOR, Décio dos Santos

; ABRAHÃO, Aline Corrêa

; ANDRADE, Bruno Augusto Benevenuto de

; AGOSTINI, Michelle

; MORAES, Renata Mendonça

; ANBINDER, Ana Lia

; DOURADO, Pedro Henrique Silva

; SANTOS, Teresa Cristina Ribeiro Bartholomeu dos

; PIRES, Fábio Ramoa

; BORDIGNON, Natalia Cristina Trentin

; GONDAK, Rogério Oliveira

; DE OLIVEIRA, Marcia Gaiger

; CARRARD, Vinicius Coelho

; MARTINS, Manoela Domingues

; SOUSA-NETO, Sebastião Silvério

; ARANTES, Diego Antônio Costa

; MENDONÇA, Elismauro Francisco

; CIESLAK-SANCHES, Silvia Roberta

; ANTUNES, Daniella Moraes

; AMARAL-SILVA, Gleyson Kleber do

; MANIERI, Patricia Rubia

; RAMALHO, Luciana Maria Pedreira

; DOS SANTOS, Jean Nunes

; LEONEL, Augusto César Leal da Silva

; PEREZ, Danyel Elias da Cruz

; VERHEUL, Hannah Carmem Carlos Ribeiro Silva

; BARROSO, Keila Martha Amorim

; RODRIGUES, Flávia Luiza Santos

; GONZAGA, Amanda Katarinny Goes

; FERNANDES, Romana Renery

; DE SOUZA, Lélia Batista

; SOUZA, Lucas Lacerda de

; PONTES, Flávia Sirotheau Corrêa

; PONTES, Hélder Antônio Rebelo

; SILVA, Caroline Alfaia

; CÂMARA, Jeconias

; LIBÓRIO-KIMURA, Tatiana Nayara

; SANTOS-SILVA, Alan Roger

; LOPES, Márcio Ajudarte

; ALMEIDA, Oslei Paes de

; ROMAÑACH, Mário José

; VARGAS, Pablo Agustin

Brazilian Oral Research

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2023, Volume 37 elocation e126

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate the contribution of oral and maxillofacial pathology laboratories (OMPLs) in Brazilian public universities to the diagnosis of lip, oral cavity, and oropharyngeal squamous cell carcinoma (SCC). A cross-sectional study was performed using biopsy records from a consortium of sixteen public OMPLs from all regions of Brazil (North, Northeast, Central-West, Southeast, and South). Clinical and demographic data of patients diagnosed with lip, oral cavity, and oropharyngeal SCC between 2010 and 2019 were collected from the patients’ histopathological records. Of the 120,010 oral and maxillofacial biopsies (2010-2019), 6.9% (8,321 cases) were diagnosed as lip (0.8%, 951 cases), oral cavity (4.9%, 5,971 cases), and oropharyngeal (1.2%, 1,399 cases) SCCs. Most cases were from Brazil’s Southeast (64.5%), where six of the OMPLs analyzed are located. The predominant profile of patients with lip and oral cavity SCC was Caucasian men, with a mean age over 60 years, low schooling level, and a previous history of heavy tobacco consumption. In the oropharyngeal group, the majority were non-Caucasian men, with a mean age under 60 years, had a low education level, and were former/current tobacco and alcohol users. According to data from the Brazilian National Cancer Institute, approximately 9.9% of the total lip, oral cavity, and oropharyngeal SCCs reported over the last decade in Brazil may have been diagnosed at the OMPLs included in the current study. Therefore, this data confirms the contribution of public OMPLs with respect to the important diagnostic support they provide to the oral healthcare services extended by the Brazilian Public Health System. (OMPLs SCC. . (SCC) crosssectional cross sectional North, North (North Northeast CentralWest, CentralWest Central West, West Central-West South. South South) 201 120010 120 010 120,01 20102019, 20102019 , (2010-2019) 69 6 9 6.9 8,321 8321 8 321 (8,32 0.8%, 08 0 (0.8% 95 cases, 4.9%, 49 4 (4.9% 5971 5 971 5,97 1.2%, 12 1 2 (1.2% 1399 399 1,39 Brazils s 64.5%, 645 64.5% 64 (64.5%) located men years level consumption group nonCaucasian non formercurrent former users Institute 99 9.9 Therefore System (SCC 20 12001 01 120,0 2010201 (2010-2019 6. 8,32 832 32 (8,3 0.8% (0.8 4.9% (4.9 597 97 5,9 1.2% (1.2 139 39 1,3 64.5 (64.5% 9. 1200 120, 201020 (2010-201 8,3 83 3 (8, 0.8 (0. 4.9 (4. 59 5, 1.2 (1. 13 1, 64. (64.5 20102 (2010-20 8, (8 0. (0 4. (4 1. (1 (64. (2010-2 ( (64 (2010- (6 (2010 (201 (20 (2

https://doi.org/10.1590/1807-3107bor-2023.vol37.0126

11.

Physicochemical Characterization, Quantitative Drug Analysis, and Stability Testing of Hydroxytyrosol-loaded Poly(ԑ-caprolactone) Nanocapsules Characterization Analysis Hydroxytyrosolloaded Hydroxytyrosol loaded Polyԑcaprolactone Poly ԑ caprolactone Poly(ԑ-caprolactone
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Ribeiro, Juliana Parente Menezes

; Schebelski, Diego José

; Lyra, Amanda Martinez

; Camargo, Guilherme dos Anjos

; Nadal, Jessica Mendes

; Novatski, Andressa

; Manfron, Jane

; Farago, Paulo Vitor

Brazilian Archives of Biology and Technology

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2023, Volume 66 elocation e23230081

Resumo: En | Texto: En | PDF: En

Abstract Hydroxytyrosol (HT) is a natural phenolic compound found in leaves of olive trees. It is a photosensitive solid phytochemical constituent and an irritant substance to skin and mucosa as pure drug. HT is a lipophilic chemical constituent and shows low solubility in water, bitter taste, and instability to oxidizing atmosphere. Considering the limitations for its suitable therapeutic use, the aim of the present study was to obtain, to characterize, to quantify, and to evaluate the stability of HT-loaded poly(ԑ-caprolactone) nanocapsules for its further use in pharmaceutical and nutraceutical products. Nanocapsules were prepared by method of interfacial deposition of the preformed polymer. The formulations were characterized by morphological and spectroscopic methods. The UHPLC-PDA analytical method was developed and validated for quantifying the HT encapsulation. Physicochemical stability assay was performed for 120 days. Nanocapsules were successfully obtained by the proposed method. The morphological evaluation demonstrated the drug absence in the nanocapsule surface. Fourier-transform infrared spectroscopy demonstrated the drug nanoencapsulation. The analytical method was validated and confirmed a high HT encapsulation efficiency over 95%. Considering the physicochemical stability testing, the polydispersity index changed after 30 days for NC-2 (HT at 2 mg/mL) and after 90 days for NC-5 (HT at 5 mg/mL). Zeta potential changed after 60 days for both formulations (NC-2 and NC-5). pH values were modified after 60 days for NC-5 and after 90 days for NC-2. HT-loaded PCL nanocapsules demonstrate adequate physicochemical features and high drug encapsulation. The different formulations revealed stability changes from 30 to 90 days. Additional in vitro and in vivo evaluations may be performed in order to use these nanoformulations for treating several diseases based on oxidative-inflammatory environments. trees water taste atmosphere obtain characterize quantify HTloaded loaded polyԑcaprolactone poly ԑ caprolactone poly(ԑ-caprolactone products polymer methods UHPLCPDA UHPLC PDA 12 surface Fouriertransform Fourier transform nanoencapsulation 95 95% testing 3 NC2 NC NC- mg/mL mgmL mg mL 9 NC5 mg/mL. . 6 (NC- NC5. NC-5) NC2. 2. oxidativeinflammatory oxidative inflammatory environments 1 (NC

https://doi.org/10.1590/1678-4324-2023230081

12.

IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva IMPACTOMR IMPACTO MR IMPACTO-MR
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Tomazini, Bruno M

; Nassar Jr, Antonio Paulo

; Lisboa, Thiago Costa

; Azevedo, Luciano César Pontes de

; Veiga, Viviane Cordeiro

; Catarino, Daniela Ghidetti Mangas

; Fogazzi, Debora Vacaro

; Arns, Beatriz

; Piastrelli, Filipe Teixeira

; Dietrich, Camila

; Negrelli, Karina Leal

; Jesuíno, Isabella de Andrade

; Reis, Luiz Fernando Lima

; Mattos, Renata Rodrigues de

; Pinheiro, Carla Cristina Gomes

; Luz, Mariane Nascimento

; Spadoni, Clayse Carla da Silva

; Moro, Elisângela Emilene

; Bueno, Flávia Regina

; Sampaio, Camila Santana Justo Cintra

; Silva, Débora Patrício

; Baldassare, Franca Pellison

; Silva, Ana Cecilia Alcantara

; Veiga, Thabata

; Barbante, Leticia

; Lambauer, Marianne

; Campos, Viviane Bezerra

; Santos, Elton

; Santos, Renato Hideo Nakawaga

; Laranjeiras, Ligia Nasi

; Valeis, Nanci

; Santucci, Eliana

; Miranda, Tamiris Abait

; Patrocínio, Ana Cristina Lagoeiro do

; Carvalho, Andréa de

; Sousa, Eduvirgens Maria Couto de

; Sousa, Ancelmo Honorato Ferraz de

; Malheiro, Daniel Tavares

; Bezerra, Isabella Lott

; Rodrigues, Mirian Batista

; Malicia, Julliana Chicuta

; Silva, Sabrina Souza da

; Gimenes, Bruna dos Passos

; Sesin, Guilhermo Prates

; Zavascki, Alexandre Prehn

; Sganzerla, Daniel

; Medeiros, Gregory Saraiva

; Santos, Rosa da Rosa Minho dos

; Silva, Fernanda Kelly Romeiro

; Cheno, Maysa Yukari

; Abrahão, Carolinne Ferreira

; Oliveira Junior, Haliton Alves de

; Rocha, Leonardo Lima

; Nunes Neto, Pedro Aniceto

; Pereira, Valéria Chagas

; Paciência, Luis Eduardo Miranda

; Bueno, Elaine Silva

; Caser, Eliana Bernadete

; Ribeiro, Larissa Zuqui

; Fernandes, Caio Cesar Ferreira

; Garcia, Juliana Mazzei

; Silva, Vanildes de Fátima Fernandes

; Santos, Alisson Junior dos

; Machado, Flávia Ribeiro

; Souza, Maria Aparecida de

; Ferronato, Bianca Ramos

; Urbano, Hugo Corrêa de Andrade

; Moreira, Danielle Conceição Aparecida

; Souza-Dantas, Vicente Cés de

; Duarte, Diego Meireles

; Coelho, Juliana

; Figueiredo, Rodrigo Cruvinel

; Foreque, Fernanda

; Romano, Thiago Gomes

; Cubos, Daniel

; Spirale, Vladimir Miguel

; Nogueira, Roberta Schiavon

; Maia, Israel Silva

; Zandonai, Cassio Luis

; Lovato, Wilson José

; Cerantola, Rodrigo Barbosa

; Toledo, Tatiana Gozzi Pancev

; Tomba, Pablo Oscar

; Almeida, Joyce Ramos de

; Sanches, Luciana Coelho

; Pierini, Leticia

; Cunha, Mariana

; Sousa, Michelle Tereza

; Azevedo, Bruna

; Dal-Pizzol, Felipe

; Damasio, Danusa de Castro

; Bainy, Marina Peres

; Beduhn, Dagoberta Alves Vieira

; Jatobá, Joana D’Arc Vila Nova

; Moura, Maria Tereza Farias de

; Rego, Leila Rezegue de Moraes

; Silva, Adria Vanessa da

; Oliveira, Luana Pontes

; Sodré Filho, Eliene Sá

; Santos, Silvana Soares dos

; Neves, Itallo de Lima

; Leão, Vanessa Cristina de Aquino

; Paes, João Lucidio Lobato

; Silva, Marielle Cristina Mendes

; Oliveira, Cláudio Dornas de

; Santiago, Raquel Caldeira Brant

; Paranhos, Jorge Luiz da Rocha

; Wiermann, Iany Grinezia da Silva

; Pedroso, Durval Ferreira Fonseca

; Sawada, Priscilla Yoshiko

; Prestes, Rejane Martins

; Nascimento, Glícia Cardoso

; Grion, Cintia Magalhães Carvalho

; Carrilho, Claudia Maria Dantas de Maio

; Dantas, Roberta Lacerda Almeida de Miranda

; Silva, Eliane Pereira

; Silva, Antônio Carlos da

; Oliveira, Sheila Mara Bezerra de

; Golin, Nicole Alberti

; Tregnago, Rogerio

; Lima, Valéria Paes

; Silva, Kamilla Grasielle Nunes da

; Boschi, Emerson

; Buffon, Viviane

; Machado, André Sant’Ana

; Capeletti, Leticia

; Foernges, Rafael Botelho

; Carvalho, Andréia Schubert de

; Oliveira Junior, Lúcio Couto de

; Oliveira, Daniela Cunha de

; Silva, Everton Macêdo

; Ribeiro, Julival

; Pereira, Francielle Constantino

; Salgado, Fernanda Borges

; Deutschendorf, Caroline

; Silva, Cristofer Farias da

; Gobatto, Andre Luiz Nunes

; Oliveira, Carolaine Bomfim de

; Dracoulakis, Marianna Deway Andrade

; Alvaia, Natália Oliveira Santos

; Souza, Roberta Machado de

; Araújo, Larissa Liz Cardoso de

; Melo, Rodrigo Morel Vieira de

; Passos, Luiz Carlos Santana

; Vidal, Claudia Fernanda de Lacerda

; Rodrigues, Fernanda Lopes de Albuquerque

; Kurtz, Pedro

; Shinotsuka, Cássia Righy

; Tavares, Maria Brandão

; Santana, Igor das Virgens

; Gavinho, Luciana Macedo da Silva

; Nascimento, Alaís Brito

; Pereira, Adriano J

; Cavalcanti, Alexandre Biasi

Revista Brasileira de Terapia Intensiva

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Dez 2022, Volume 34 Nº 4 Páginas 418 - 425

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials. Objective IMPACTOMR, IMPACTOMR IMPACTO MR, MR careassociated associated multidrugresistant multidrug resistant bacteria Methods selection collection objectives Results System status scores diagnoses laboratory stay others 201 2020 33983 33 983 33,98 5 Conclusion trials 20 202 3398 3 98 33,9 2 339 9 33,

RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. Objetivo IMPACTOMR, IMPACTOMR IMPACTO MR, MR saúde Métodos Resultados System demográficos comorbidades funcional secundários laboratoriais outros 201 2020 33983 33 983 33.98 5 principal Conclusão multicêntricos 20 202 3398 3 98 33.9 2 339 9 33.

https://doi.org/10.5935/0103-507x.20220209-pt

13.

O que mudou entre os períodos de pico e de platô durante a primeira onda do SARS-CoV-2? Estudo multicêntrico português em unidades de cuidados intensivos SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV-2 SARS-CoV- SARS-CoV
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Pereira, Rui Antunes

; Sousa, Marta

; Cidade, José Pedro

; Melo, Luís

; Lopes, Diogo

; Ventura, Sara

; Aragão, Irene

; Lima Neto, Raul Miguel de Freitas

; Molinos, Elena

; Marques, Ana

; Cardoso, Nelson

; Marino, Flávio

; Monteiro, Filipa Brás

; Oliveira, Ana Pinho

; Silva, Rogério C

; Real, André Miguel Neto

; Banheiro, Bruno Sarmento

; Reis, Renato

; Adão-Serrano, Maria

; Cracium, Ana

; Valadas, Ana

; Ribeiro, João Miguel

; Póvoa, Pedro

; Tapadinhas, Camila

; Mendes, Vítor

; Coelho, Luís

; Maia, Raquel

; Freitas, Paulo Telles

; Ferreira, Isabel Amorim

; Ramires, Tiago

; Val-Flores, Luís Silva

; Cascão, Mariana

; Alves, Rita

; Rodeia, Simão C

; Barrigoto, Cleide

; Cardiga, Rosa

; Silva, Maria João Ferreira da

; Vale, Bruno

; Fonseca, Tatiana

; Rios, Ana Lúcia

; Camões, João

; Pérez, Danay

; Cabral, Susana

; Ribeiro, Maria Inês

; Mendes, João João

; Gouveia, João

; Fernandes, Susana Mendes

Revista Brasileira de Terapia Intensiva

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Dez 2022, Volume 34 Nº 4 Páginas 433 - 442

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To analyze and compare COVID-19 patient characteristics, clinical management and outcomes between the peak and plateau periods of the first pandemic wave in Portugal. Methods: This was a multicentric ambispective cohort study including consecutive severe COVID-19 patients between March and August 2020 from 16 Portuguese intensive care units. The peak and plateau periods, respectively, weeks 10 - 16 and 17 - 34, were defined. Results: Five hundred forty-one adult patients with a median age of 65 [57 - 74] years, mostly male (71.2%), were included. There were no significant differences in median age (p = 0.3), Simplified Acute Physiology Score II (40 versus 39; p = 0.8), partial arterial oxygen pressure/fraction of inspired oxygen ratio (139 versus 136; p = 0.6), antibiotic therapy (57% versus 64%; p = 0.2) at admission, or 28-day mortality (24.4% versus 22.8%; p = 0.7) between the peak and plateau periods. During the peak period, patients had fewer comorbidities (1 [0 - 3] versus 2 [0 - 5]; p = 0.002) and presented a higher use of vasopressors (47% versus 36%; p < 0.001) and invasive mechanical ventilation (58.1 versus 49.2%; p < 0.001) at admission, prone positioning (45% versus 36%; p = 0.04), and hydroxychloroquine (59% versus 10%; p < 0.001) and lopinavir/ritonavir (41% versus 10%; p < 0.001) prescriptions. However, a greater use of high-flow nasal cannulas (5% versus 16%, p < 0.001) on admission, remdesivir (0.3% versus 15%; p < 0.001) and corticosteroid (29% versus 52%, p < 0.001) therapy, and a shorter ICU length of stay (12 days versus 8, p < 0.001) were observed during the plateau. Conclusion: There were significant changes in patient comorbidities, intensive care unit therapies and length of stay between the peak and plateau periods of the first COVID-19 wave. Objective COVID19 COVID 19 COVID-1 characteristics Portugal Methods 202 1 units respectively 34 defined Results fortyone forty one 6 57 [5 74 years 71.2%, 712 71.2% , 71 (71.2%) included 0.3, 03 0.3 0 3 0.3) 40 (4 39 0.8, 08 0.8 8 0.8) pressurefraction pressure fraction 139 (13 136 0.6, 06 0.6 0.6) 57% (57 64% 64 0.2 02 admission 28day day 28 24.4% 244 24 4 (24.4 22.8% 228 22 0.7 07 7 period ( [ 5 5] 0.002 0002 002 47% 47 (47 36% 36 0.001 0001 001 58.1 581 58 (58. 49.2% 492 49 45% 45 (45 0.04, 004 0.04 04 0.04) 59% 59 (59 10% lopinavirritonavir lopinavir ritonavir 41% 41 (41 prescriptions However highflow high flow 5% (5 16% 0.3% (0.3 15% 15 29% 29 (29 52 52% 12 Conclusion COVID1 COVID- 20 71.2 (71.2% 0. 13 24.4 (24. 22.8 0.00 000 00 58. (58 49.2 0.0 (0. (2 71. (71.2 24. (24 22. 49. (0 (71. (71 (7

RESUMO Objetivo: Analisar e comparar as características de pacientes críticos com a COVID-19, a abordagem clínica e os resultados entre os períodos de pico e de platô na primeira onda pandêmica em Portugal. Métodos: Este foi um estudo de coorte multicêntrico ambispectivo, que incluiu pacientes consecutivos com a forma grave da COVID-19 entre março e agosto de 2020 de 16 unidades de terapia intensiva portuguesas. Definiram-se as semanas 10 - 16 e 17 - 34 como os períodos de pico e platô. Resultados: Incluíram-se 541 pacientes adultos com mediana de idade de 65 [57 - 74] anos, a maioria do sexo masculino (71,2%). Não houve diferenças significativas na mediana de idade (p = 0,3), no Simplified Acute Physiology Score II (40 versus 39; p = 0,8), na pressão parcial de oxigênio/fração inspirada de oxigênio (139 versus 136; p = 0,6), na terapia com antibióticos na admissão (57% versus 64%; p = 0,2) ou na mortalidade aos 28 dias (24,4% versus 22,8%; p = 0,7) entre o período de pico e platô. Durante o período de pico, os pacientes tiveram menos comorbidades (1 [0 - 3] versus 2 [0 - 5]; p = 0,002); fizeram mais uso de vasopressores (47% versus 36%; p < 0,001) e ventilação mecânica invasiva na admissão (58,1% versus 49,2%; p < 0,001), e tiveram mais prescrição de hidroxicloroquina (59% versus 10%; p < 0,001), lopinavir/ritonavir (41% versus 10%; p < 0,001) e posição prona (45% versus 36%; p = 0,04). Entretanto, durante o platô, observou-se maior uso de cânulas nasais de alto fluxo (5% versus 16%; p < 0,001) na admissão, remdesivir (0,3% versus 15%; p < 0,001) e corticosteroides (29% versus 52%; p < 0,001), além de menor tempo de internação na unidade de terapia intensiva (12 versus 8 dias; p < 0,001). Conclusão: Houve mudanças significativas nas comorbidades dos pacientes, nos tratamentos da unidade de terapia intensiva e no tempo de internação entre os períodos de pico e platô na primeira onda da COVID-19. Objetivo COVID19, COVID19 COVID 19, 19 Portugal Métodos ambispectivo COVID-1 202 1 portuguesas Definiramse Definiram se 3 Resultados Incluíramse Incluíram 54 6 57 [5 74 anos 71,2%. 712 71,2% . 71 (71,2%) 0,3, 03 0,3 , 0 0,3) 40 (4 39 0,8, 08 0,8 0,8) oxigêniofração fração 139 (13 136 0,6, 06 0,6 0,6) 57% (57 64% 64 0,2 02 24,4% 244 24 4 (24,4 22,8% 228 22 0,7 07 7 ( [ 5 5] 0,002 0002 002 0,002) 47% 47 (47 36% 36 0,001 0001 001 58,1% 581 58 (58,1 49,2% 492 49 0,001, 59% 59 (59 10% lopinavirritonavir lopinavir ritonavir 41% 41 (41 45% 45 (45 0,04. 004 0,04 04 0,04) Entretanto observouse observou 5% (5 16% 0,3% (0,3 15% 15 29% 29 (29 52% 52 12 0,001. Conclusão COVID19. 19. COVID1 COVID- 20 71,2 (71,2% 0, 13 24,4 (24, 22,8 0,00 000 00 58,1 (58, 49,2 0,0 (0, (2 71, (71,2 24, (24 22, 58, (58 49, (0 (71, (71 (7

https://doi.org/10.5935/0103-507x.20210037-pt

14.

Salivary Cortisol and Sustained Auditory Attention in Children with and without Cleft Lip and Palate
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Fernandes, Viviane Mendes

; Mondelli, Maria Fernanda Capoani Garcia

; José, Maria Renata

; Gomide, Márcia Ribeiro

; Lauris, José Roberto Pereira

; Feniman, Mariza Ribeiro

International Archives of Otorhinolaryngology

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Dez 2022, Volume 26 Nº 4 Páginas 605 - 614

Resumo: En | Texto: En | PDF: En

Abstract Introduction Cortisol is a hormone involved in the response to stress. Attention is a function that can change due to exposure to stress. Objectives To verify the correlation between the level of salivary cortisol and sustained auditory attention in children with cleft lip and palate, as well as to compare the results of the variables analyzed between female and male patients. Methods In total, 103 children aged 6 to 11 years, were divided into 2 groups: those with cleft lip and palate (experimental group, EG; n = 69) and the control group (CG; n = 34). The Sustained Auditory Attention Ability Test (SAAAT) and salivary cortisol levels, measured by an enzyme immunoassay kit (Salimetrics, Stage College, PA, US), were calculated and compared regarding the two groups. The statistical tests used were the Mann-Whitney test and the Spearman correlation. Results The median level of salivary cortisol was of 0.03615 μl/dL and 0.18000 μl/dL respectively for the EG and CG, with a significant difference between the groups (p =0.000). Absence of statistical significance (total error score = 0.656; vigilance decrement = 0.051) was observed the for SAAAT among the EG (median total error score = 12.00; 25th percentile [25%] = 7.00; 75th percentile [75%] = 21.00; and vigilance decrement = 1.00; 25% = 0.00; 75% = 2.50) and the CG (median total error score = 12.00; 25% = 6.00; 75% = 24.00; and vigilance decrement = 0.00; 25% = -1.00; 75% = 2.00). Conclusion All children had median levels of salivary cortisol and scores for sustained auditory attention within normal parameters. A significant correlation between the level of salivary cortisol and the ability to sustain auditory attention was observed in children without cleft lip and palate. There were no differences regarding the SAAAT and salivary cortisol between female and male patients. stress patients 10 1 years experimental 69 (CG 34. 34 . 34) (SAAAT Salimetrics, Salimetrics (Salimetrics College PA US, US , US) MannWhitney Mann Whitney 003615 0 03615 0.0361 μldL μl dL 018000 18000 0.1800 p =0.000. 0000 =0.000 000 =0.000) 0.656 0656 656 0.051 0051 051 12.00 1200 12 00 th 25 [25% 7.00 700 7 75 [75% 21.00 2100 21 1.00 100 0.00 2.50 250 50 6.00 600 24.00 2400 24 -1.00 2.00. 200 2.00 2.00) parameters 3 00361 0361 0.036 01800 1800 0.180 =0.00 0.65 065 65 0.05 005 05 12.0 120 [25 7.0 70 [75 21.0 210 1.0 0.0 2.5 5 6.0 60 24.0 240 -1.0 20 2.0 0036 036 0.03 0180 180 0.18 =0.0 0.6 06 12. [2 7. [7 21. 1. 0. 2. 6. 24. -1. 003 03 018 18 0.1 =0. [ -1 01 =0 -

https://doi.org/10.1055/s-0041-1735130

15.

Sistemas de saúde, mecanismos de governança e porosidade governamental em perspectiva comparada saúde
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Ribeiro, José Mendes

; Vaitsman, Jeni

; Motta, José Inácio Jardim

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Nov 2022, Volume 46 Nº spe4 Páginas 10 - 25

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT This paper presents a comparative analysis of ten selected countries regarding the established relationships of participative governance, socioeconomic profiles, and health care systems with health outcomes and Global Governance Indicators. Significant sources were databases produced or compiled by the World Bank. The analytical model adopts an institutionalist approach to address social protection and participative governance – the latter, as used, recovers notions of societal participation, government porosity, and responsive regulation. Outcomes show a solid convergence of more distributive socioeconomic profiles, more universalist health systems with higher government financing, and better governance indicators. This analysis supports the arguments that socially virtuous institutional paths subjected to positive feedback favor better social and political outcomes over time. profiles Indicators Bank latter used participation porosity regulation financing indicators time

RESUMO O artigo apresenta uma análise comparada de dez países selecionados sobre as relações entre governança participativa, perfis socioeconômicos e sistemas de saúde com resultados sanitários e de Indicadores de Governança Global. As fontes principais foram bases de dados produzidas e/ou compiladas pelo Banco Mundial. O modelo analítico se apoia em enfoque institucionalista para tratar de proteção social e governança participativa – esta, como utilizada, recobre as noções de participação social, porosidade governamental e regulação responsiva. Os resultados mostram uma sólida convergência entre perfis socioeconômicos mais distributivos, sistemas sanitários com maior financiamento público e universalismo e melhores indicadores de governança. Esta análise reforça os argumentos sobre trajetórias institucionais socialmente virtuosas e sujeitas a reforços positivos capazes de produzir melhores resultados sociais e políticos ao longo do tempo. Global eou ou Mundial esta utilizada responsiva distributivos tempo

https://doi.org/10.1590/0103-11042022e401

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