Fruits of Schinus terebinthifolia Raddi were investigated. A fast and efficient method for the simultaneous determination of 11 polyphenolic substances by high performance liquid chromatography-diode array detector (HPLC-DAD) was applied. Limits of quantification ranged between 0.78 and 3.14 mg L-1. High concentrations of kaempferol were found. An exploratory evaluation was performed using principal component analysis (PCA) for fruit origin differentiation. Total phenolic content (TPC) ranged from 274 to 517 mg GAE 100 g-1; total flavonoid content (TFC) ranged from 101 to 283 mg QE 100 g-1. In vitro analyses showed that antioxidant capacity with 2,2-diphenyl-1-picrylhydrazyl (DPPH) ranged from 1.7 to 7 µM DPPH 100 g-1. The bacteriostatic and bactericidal effect were also evaluated against: Bacillus subtilis, B. cereus, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella choleraesuis, Candida albicans and C. glabrata, using broth microdilution assay. It can be inferred that S. terebinthifolia Raddi fruit has the potential to act as an ally in the search for new alternatives in the action against pathogens, and it can be used as a potential natural antioxidant and antimicrobial agent. Metals (Cu, Fe, Mg, Mn and Zn) were also determined by flame atomic absorption spectrometry (FAAS), with emphasis on high concentrations of Mg, Zn and Fe. investigated 1 chromatographydiode chromatography diode HPLCDAD HPLC DAD (HPLC-DAD applied 078 0 78 0.7 314 3 14 3.1 L1. L1 L 1. L-1 found PCA (PCA differentiation TPC (TPC 27 51 10 g1 g g-1 TFC (TFC 28 g1. 2,2diphenyl1picrylhydrazyl 22diphenyl1picrylhydrazyl diphenylpicrylhydrazyl 2,2 diphenyl picrylhydrazyl 2 (DPPH 17 subtilis B cereus aureus coli aeruginosa choleraesuis C glabrata assay S pathogens agent Cu, Cu (Cu Fe Mg FAAS, FAAS , (FAAS) 07 0. 31 3. L- 5 g- 2diphenyl1picrylhydrazyl 22 2, (FAAS

We report a facile hydrothermal method for the synthesis of niobium pentoxide (Nb2O5) under two different temperatures, 120 °C (Nb2O5-120) and 150 °C (Nb2O5-150). The obtained materials were characterized by structural, optical and morphological techniques. Also, the photocatalytic properties of the Nb2O5 samples were evaluated in two reactions under ultraviolet (UVC) irradiation: degradation of methylene blue (MB) and indigo carmine (IC) dyes; and esterification of free fatty acids (FFA) present in waste cooking oil (WCO). The Nb2O5 was formed at different temperatures of synthesis, and the increase in temperature did not cause significant changes in the structural and optical characteristics, but resulted in an increased surface area of the synthesized materials. Both synthesized materials showed excellent efficiency for dye photodegradation. The sample Nb2O5-150 presented the best performance for the MB photodegradation, with almost 85% of the removal efficiency. In this case, the adsorption of MB molecules on the surface of the material was high due to the favorable electrostatic interaction and also because of its high surface area. For the IC photodegradation, the adsorption was insignificant, and both samples presented approximately 100% of the removal efficiency. These materials were also promising for the reduction of free fat acids in waste oil by photoesterification. NbO Nb O (Nb2O5 12 C Nb2O5120 (Nb2O5-120 15 Nb2O5150. Nb2O5150 . (Nb2O5-150) techniques Also Nb2O UVC (UVC irradiation (MB (IC dyes FFA (FFA WCO. WCO (WCO) characteristics photodegradation Nb2O5-15 85 case insignificant 100 photoesterification (Nb2O 1 Nb2O512 (Nb2O5-12 Nb2O515 (Nb2O5-150 (WCO Nb2O5-1 8 10 Nb2O51 (Nb2O5-1 (Nb2O5-15 Nb2O5- (Nb2O5-

Resumo Introdução: A doença renal crônica (DRC) e a síndrome metabólica (SM) são reconhecidas como problemas de saúde pública relacionados ao excesso de peso e a fatores cardiometabólicos. O objetivo deste estudo foi desenvolver um modelo para prever a SM em pessoas com DRC. Métodos: Este foi um estudo transversal prospectivo de pacientes de um centro de referência em São Luís, MA, Brasil. A amostra incluiu voluntários adultos classificados de acordo com a presença de DRC leve ou grave. Para o rastreamento da SM, o algoritmo de classificação k-nearest neighbors (KNN) foi utilizado com os seguintes dados: sexo, tabagismo, circunferência do pescoço e relação cintura-quadril. Os resultados foram considerados significativos com p < 0,05. Resultados: Foram avaliados 196 pacientes adultos com média de idade de 44,73 anos, 71,9% do sexo feminino, 69,4% com sobrepeso e 12,24% com DRC. Desses últimos, 45,8% apresentaram SM, a maioria tinha até 3 componentes metabólicos alterados, e o grupo com DRC apresentou significância estatística em: circunferência da cintura, pressão arterial sistólica, pressão arterial diastólica e glicemia de jejum. O algoritmo KNN comprovou ser um bom preditor para a triagem de SM com acurácia e sensibilidade de 79% e especificidade de 80% (área sob a curva ROC – AUC = 0,79). Conclusão: O algoritmo KNN pode ser usado como um método de triagem de baixo custo para avaliar a presença de SM em pessoas com DRC. Introdução (DRC (SM cardiometabólicos Métodos Luís MA Brasil grave knearest k nearest (KNN dados tabagismo cinturaquadril. cinturaquadril cintura quadril. quadril cintura-quadril 005 0 05 0,05 Resultados 19 4473 44 73 44,7 anos 719 71 9 71,9 feminino 694 69 4 69,4 1224 12 24 12,24 últimos 458 45 8 45,8 alterados sistólica jejum 79 80 área 0,79. 079 0,79 . 0,79) Conclusão 00 0,0 1 447 7 44, 71, 6 69, 122 2 12,2 45, 07 0,7 0, 12,

Abstract Introduction: Chronic kidney disease (CKD) and metabolic syndrome (MS) are recognized as public health problems which are related to overweight and cardiometabolic factors. The aim of this study was to develop a model to predict MS in people with CKD. Methods: This was a prospective cross-sectional study of patients from a reference center in São Luís, MA, Brazil. The sample included adult volunteers classified according to the presence of mild or severe CKD. For MS tracking, the k-nearest neighbors (KNN) classifier algorithm was used with the following inputs: gender, smoking, neck circumference, and waist-to-hip ratio. Results were considered significant at p < 0.05. Results: A total of 196 adult patients were evaluated with a mean age of 44.73 years, 71.9% female, 69.4% overweight, and 12.24% with CKD. Of the latter, 45.8% had MS, the majority had up to 3 altered metabolic components, and the group with CKD showed statistical significance in: waist circumference, systolic blood pressure, diastolic blood pressure, and fasting blood glucose. The KNN algorithm proved to be a good predictor for MS screening with 79% accuracy and sensitivity and 80% specificity (area under the ROC curve – AUC = 0.79). Conclusion: The KNN algorithm can be used as a low-cost screening method to evaluate the presence of MS in people with CKD. Introduction (CKD (MS factors Methods crosssectional cross sectional Luís MA Brazil tracking knearest k nearest (KNN inputs gender smoking circumference waisttohip hip ratio 005 0 05 0.05 19 4473 44 73 44.7 years 719 71 9 71.9 female 694 69 4 69.4 1224 12 24 12.24 latter 458 45 8 45.8 components pressure glucose 79 80 area 0.79. 079 0.79 . 0.79) Conclusion lowcost low cost 00 0.0 1 447 7 44. 71. 6 69. 122 2 12.2 45. 07 0.7 0. 12.

ABSTRACT Semi-hydroponic systems are an alternative for vegetable production, combining inert substrates and nutrient solutions and requiring less water. Bell pepper (Capsicum annuum L.) is a vegetable species of the Solanaceae family that is mainly grown in protected environments, which provide several financial and agronomic advantages for their management. Advancements in research and the need for high-quality productions have significantly contributed to this horticultural crop through the selection of productive cultivars with high economic yields and adapted to favorable conditions. The objective of this study was to evaluate growth, physiological, and production characteristics of colored bell pepper cultivars in a semi-hydroponic system. The experiment was conducted in a completely randomized design, using four colored pepper cultivars (Spinel, Bachata, Fulgor, and Red Jet), five evaluation times (7, 14, 21, 28, and 35 days after transplanting - DAT) for growth variables, and evaluations at two developmental stages (45 and 95 DAT) for physiological variables. Production and post-harvest variables were not evaluated in different times, considering only the cultivar factor, with five replications, each plot consisting of two plants. Chlorophyll a and b, maximum fluorescence, and water use efficiency were greater in bell pepper plants of the cultivar Spinel. The sweetest fruits were those of the cultivar Bachata. The cultivar Fulgor was the most suitable for growth under the studied conditions due to its greater fruit length and diameter and total fruit weight. Semihydroponic Semi hydroponic Capsicum L. L environments management highquality quality semihydroponic semi system design Spinel, Spinel (Spinel Bachata Jet, Jet , Jet) 7, 7 (7 14 21 28 3 DAT 45 (4 9 postharvest post harvest factor replications b fluorescence weight ( 1 2 4

RESUMO O sistema semi-hidropônico é uma alternativa para a produção de hortaliças, pois combina substrato inerte e solução nutritiva, necessitando de menos água. O pimentão é uma hortaliça da família Solanaceae, principalmente produzida em ambiente protegido, apresentando diversas vantagens financeiras e agronômicas no seu manejo. Com os avanços nas pesquisas e a necessidade de uma produção de qualidade, selecionar cultivares produtivas e com alto rendimento econômico, adaptadas às condições favoráveis, torna-se um grande avanço para esta cultura hortícola. O objetivo deste estudo foi avaliar o crescimento, características fisiológicas e produtivas das cultivares Red Jet, Spinel, Bachata e Fulgor em sistema semi-hidropônico. O delineamento experimental foi inteiramente casualizado com quatro cultivares de pimentão colorido (Spinel, Bachata, Fulgor e Red Jet) subdivididas em cinco épocas de avaliação (7, 14, 21, 28 e 35 dias após transplantio - DAT) para as variáveis de crescimento e duas épocas (45 e 95 DAT) de avaliação para fisiologia. As variáveis produtivas e pós-colheita não foram subdivididas no tempo, levando-se em consideração apenas o fator cultivar para estas variáveis, com cinco repetições, sendo cada parcela composta por duas plantas. Os índices de clorofila a e b, fluorescência máxima e eficiência no uso da água foram maiores nas plantas de pimentão da cultivar Spinel. Os frutos mais doces foram obtidos com a cultivar Bachata. A cultivar Fulgor foi a mais indicada para cultivo nas condições estudadas devido ao maior comprimento, diâmetro e peso médio dos frutos. semihidropônico semi hidropônico hortaliças nutritiva Solanaceae protegido manejo qualidade econômico favoráveis tornase torna se hortícola Jet Spinel semihidropônico. hidropônico. (Spinel 7, 7 (7 14 21 2 3 DAT 45 (4 9 fisiologia póscolheita pós colheita tempo levandose levando repetições b comprimento ( 1 4

Abstract Nowadays, despite the implementation of new wind farms in Brazil, it still is difficult to form partnerships with companies in the sector, which significantly contributes to the gap in information provided by national literature and the lack of knowledge about the mechanical behavior of wind turbines subjected to transient wind effects. Therefore, through a Research and Development Project to optimize and improve modeling in wind systems, the Brazilian electric power company Eletrobras Furnas aims to facilitate the construction of smaller wind turbines to supply energy to regions far from the Brazilian coast that do not have high generation potential due to the incidence of low-speed winds. Two relevant aspects directly linked to the performance of this kind of structures are: (i) determining their natural frequency and (ii) ensuring that this frequency does not coincide with any external vibration frequency that the structure may experience in its lifetime. Wind turbines are complex systems with many degrees of freedom and their own frequencies associated with the respective mode shapes in which they naturally vibrate. These frequencies are inversely related to the mass and directly related to the stiffness of the structure. Thus, through numerical modeling using the Finite Element Method, the present article aims to list some of the main factors that can affect the prediction of the natural frequency of a real-scale wind turbine prototype and to evaluate its dynamic behavior, considering its rotor revolution frequency, its blade passing frequency and the wind characteristics of its operating area. Nowadays Brazil sector effects Therefore lowspeed low speed winds i (i ii (ii lifetime vibrate Thus Method realscale real scale area

ABSTRACT Introduction: Anemia is frequent in patients undergoing replacement therapy for kidney failure. Anemia in the pre- and post-transplantation period might be related to kidney transplant outcomes. The current study therefore sought to assess the relationship between anemia, delayed allograft function (DGF), chronic kidney allograft dysfunction (CAD), and death from any cause following kidney transplantation from a deceased donor. Methods: This was a retrospective study with 206 kidney transplant patients of deceased donors. We analyzed deceased donors’ and kidney transplant patients’ demographic data. Moreover, we compared biochemical parameters, anemia status, and medicines between DGF and non-DGF groups. Afterward, we performed a multivariate analysis. We also evaluated outcomes, such as CAD within one year and death in ten years. Results: We observed a lower frequency of pre-transplant hemoglobin concentration (Hb) but higher frequency of donor-serum creatinine and red blood transfusion within one week after transplantation in the group with DGF. In addition, there was an independent association between Hb concentration before transplantation and DGF [OR 0.252, 95%CI: 0.159–0.401; p < 0.001]. There was also an association between Hb concentration after six months of kidney transplantation and both CAD [OR 0.798, 95% CI: 0.687–0.926; p = 0.003] and death from any cause. Conclusion: An association was found between pre-transplantation anemia and DGF and between anemia six months after transplantation and both CAD and death by any cause. Thus, anemia before or after transplantation affects the outcomes for patients who have undergone kidney transplantation from a deceased donor.

RESUMO Introdução: A anemia é frequente em pacientes submetidos à terapia substitutiva para insuficiência renal. A anemia nos períodos pré e pós-transplante pode estar relacionada aos desfechos do transplante renal. Portanto, o presente estudo buscou avaliar a relação entre anemia, função retardada do enxerto (FRE), disfunção crônica do enxerto renal (DCE) e óbito por qualquer causa após transplante renal de doador falecido. Métodos: Este foi um estudo retrospectivo com 206 pacientes transplantados renais de doadores falecidos. Analisamos dados demográficos de doadores falecidos e pacientes transplantados renais. Além disso, comparamos parâmetros bioquímicos, status de anemia e medicamentos entre os grupos FRE e não-FRE. Posteriormente, realizamos uma análise multivariada. Também avaliamos desfechos, como DCE em um ano e óbito em dez anos. Resultados: Observamos menor frequência de concentração de hemoglobina (Hb) pré-transplante, mas maior frequência de creatinina sérica do doador e transfusão de hemácias no período de uma semana após o transplante no grupo FRE. Além disso, houve associação independente entre a concentração de Hb antes do transplante e a FRE [OR 0,252; IC 95%: 0,159–0,401; p < 0,001]. Houve também associação entre a concentração de Hb após seis meses de transplante renal e ambos, DCE [OR 0,798; IC95%: 0,687–0,926; p = 0,003] e óbito por qualquer causa. Conclusão: Encontrou-se uma associação entre anemia pré-transplante e FRE e entre anemia seis meses após o transplante e ambos, DCE e óbito por qualquer causa. Assim, a anemia antes ou após o transplante afeta os desfechos de pacientes que foram submetidos a transplante renal de doador falecido.

ABSTRACT BACKGROUND: Nutritional status and growth curves can affect cognitive development, increase the risk of infection, and contribute to the development of chronic diseases. Its etiology is related to food, socioeconomic, and maternal conditions. However, to date, no data on these parameters exist in the state of Goiás, Brazil. OBJECTIVE: To compare the nutritional status and growth curves of children and adolescents in the city of Goiânia, Goiás, Brazil. DESIGN AND SETTING: This was a cross-sectional study. A total of 529 individuals were recruited from a primary health center in the municipality. METHODS: To assess nutritional status, the sample was divided into three categories: 3–4, 5–10, and 11–19 years, with z-score classification considering body mass index for age. The classification of growth curves was performed considering the median height values for age, assuming two references: (a) young Brazilian population and (b) one recommended for international use. The independent sample T-test was used to compare anthropometric variables. RESULTS: The results showed that the classification of eutrophics represents a predominant percentage between both sexes (men: 03–04 = 55.4%; 05–10 = 57.6%; 11–19 = 53.5 % and women: 03–04 = 53.5%; 05–10 = 63.9%; 11–19 = 56.9%), and growth curves showed differences in specific periods in both sexes. CONCLUSIONS: It can be concluded that children and adolescents from the city of Goiânia present as predominance the eutrophic nutritional status, followed by the risk of overweight, underweight, obesity, and malnutrition of both sexes. BACKGROUND infection diseases food socioeconomic conditions However date Goiás Brazil OBJECTIVE SETTING crosssectional cross sectional study 52 municipality METHODS categories 34 3 4 3–4 510 5 10 5–10 1119 11 19 11–1 years zscore z score age references (a b (b use Ttest T test variables RESULTS men (men 0304 03 04 03–0 55.4% 554 55 0510 05 05–1 57.6% 576 57 6 535 53 53. women 53.5% 63.9% 639 63 9 56.9%, 569 56.9% , 56 56.9%) CONCLUSIONS overweight underweight obesity 3– 51 1 5–1 111 11– 030 0 03– 55.4 051 05– 57.6 63.9 56.9 5– 55. 57. 63. 56.

ABSTRACT BACKGROUND: With the increase in the older adult population, it is essential to identify the living and health conditions that can impact the quality of life of these individuals. OBJECTIVES: To identify the domains and factors associated with the quality of life of older adults under the Family Health Strategy program. DESIGN AND SETTING: This was a cross-sectional analytical study was conducted in the municipality of Palmas, Tocantins, Brazil. METHODS: We assessed 449 older adults enrolled in the Family Health Strategy program. Data were collected between April and July, 2018. World Health Organization Quality of Life Assessment (WHOQOL-OLD) was used to assess the quality of life (QoL) and multiple linear regression was used to estimate the factors associated with QoL. RESULTS: The QoL domain with the highest score was death and dying (mean = 70.4), and the lowest score was for sensory functions (mean = 61.0 points). The factors associated with QoL were single marital status (β = -4.55; P = 0.014), level of independence for daily living activities (β = 4.92; P < 0.001), self-assessment of regular health (β = 5.35; P < 0.001), and poor health (β = -8.67; P < 0.001). CONCLUSION: The death and dying domain of QoL presented the highest score. Marital status, impairment in daily activities, and health self-assessment were associated with QoL. BACKGROUND population individuals OBJECTIVES program SETTING crosssectional cross sectional Palmas Tocantins Brazil METHODS 44 July 2018 WHOQOLOLD WHOQOL OLD (WHOQOL-OLD (QoL RESULTS mean 70.4, 704 70.4 , 70 4 70.4) 610 61 0 61. points. points . points) β 4.55 455 55 -4.55 0.014, 0014 0.014 014 0.014) 4.92 492 92 0.001, 0001 0.001 001 0.001) selfassessment self assessment 5.35 535 5 35 8.67 867 8 67 -8.67 0.001. CONCLUSION 201 70. 7 6 4.5 45 -4.5 0.01 01 4.9 49 9 000 0.00 00 5.3 53 3 8.6 86 -8.6 20 4. -4. 0.0 5. 8. -8. 2 -4 0. -8 -

ABSTRACT BACKGROUND: The effect of weight loss (WL) on histopathological aspects of non-alcoholic fatty liver disease (NAFLD) may provide further insights into the dynamics of hepatic recovery after WL. OBJECTIVE: To analyze the effects of pre-operative WL on insulin resistance- and NAFLD-related histology in individuals undergoing bariatric surgery (BS) with or without pre-operative WL. DESIGN AND SETTING: A matched cross-sectional study was conducted at a public university hospital and a private clinic in Campinas, Brazil. METHODS: An analytical, observational, cross-sectional study was conducted using prospectively collected databases of individuals who underwent BS and liver biopsy at either a public tertiary university hospital (with pre-operative WL) or a private clinic (without pre-operative WL). Random electronic matching by gender, age, and body mass index (BMI) was performed and two paired groups of 24 individuals each were selected. RESULTS: Of the 48 participants, 75% were female. The mean age was 37.4 ± 9.6. The mean BMI was 38.9 ± 2.6 kg/m2. Fibrosis was the most common histopathological abnormality (91.7%). Glucose was significantly lower in the WL group (92 ± 19.1 versus 111.8 ± 35.4 mg/dL; P = 0.02). Significantly lower frequencies of macrovesicular steatosis (58.3% versus 95.8%; P = 0.004), microvesicular steatosis (12.5% versus 87.5%; P < 0.001), and portal inflammation (50% versus 87.5%; P = 0.011) were observed in the WL group. CONCLUSION: Pre-operative WL was significantly associated with lower frequencies of macro- and mi- crovesicular steatosis, portal inflammation, and lower glycemia, indicating an association between the recent trajectory of body weight and histological aspects of NAFLD. BACKGROUND (WL nonalcoholic non alcoholic NAFLD (NAFLD OBJECTIVE preoperative pre operative resistance NAFLDrelated related (BS SETTING crosssectional cross sectional Campinas Brazil METHODS analytical observational . gender (BMI 2 selected RESULTS 4 participants 75 female 374 37 37. 96 9 6 9.6 389 38 38. 26 2. kgm2 kgm kg m2 m kg/m2 91.7%. 917 91.7% 91 7 (91.7%) 92 (9 191 19 1 19. 1118 111 8 111. 354 35 35. mg/dL mgdL mg dL 0.02. 002 0.02 0 02 0.02) 58.3% 583 58 3 (58.3 95.8% 958 95 0.004, 0004 0.004 , 004 0.004) 12.5% 125 12 5 (12.5 87.5% 875 87 0.001, 0001 0.001 001 0.001) 50% 50 (50 0.011 0011 011 CONCLUSION Preoperative Pre macro mi glycemia 9. kg/m 91.7 (91.7% ( 11 00 0.0 58.3 (58. 95.8 000 0.00 12.5 (12. 87.5 (5 0.01 01 91. (91.7 0. 58. (58 95. 12. (12 87. (91. (1 (91

ABSTRACT BACKGROUND: The High Activity Arthroplasty Score (HAAS) is a self-administered questionnaire, developed in British English, that reliably and validly measures the levels of sports activities in patients following hip and knee arthroplasty surgery. OBJECTIVE: To cross-culturally adapt the HAAS to Brazilian Portuguese language. DESIGN AND SETTING: A cross-sectional study was conducted at a public university hospital in Brazil. METHODS: The Brazilian version of the HAAS was created through a six-step process: translation, synthesis, committee review, pretesting, back-translation, and submission to developers. The translation step was conducted by two independent bilingual translators, both native speakers of Brazilian Portuguese. The back-translation was performed by an independent translator, a native speaker of British English. To ensure the questionnaire's comprehensibility, 46 volunteers (51% men; average age 34-63) participated in the pre-testing step. RESULTS: The cross-cultural adaptation process necessitated modifications to certain terms and expressions to achieve cultural equivalence with the original HAAS. CONCLUSION: The HAAS has been translated from English into Brazilian Portuguese and culturally adapted for Brazil. The validation process for HAAS-Brazil is currently underway. BACKGROUND (HAAS selfadministered self administered questionnaire surgery OBJECTIVE crossculturally cross language SETTING crosssectional sectional Brazil METHODS sixstep six synthesis review pretesting backtranslation, backtranslation back developers translators translator questionnaires s comprehensibility 4 51% 51 (51 men 3463 34 63 34-63 pre testing RESULTS crosscultural CONCLUSION HAASBrazil underway 5 (5 346 3 6 34-6 ( 34-

Abstract In this study, videothermometry’s application in detecting mammary tumors in dogs is explored in-depth. The research hypothesizes that this technique can effectively identify cancerous tissues during surgery by analyzing thermal patterns. The methodology involved comparing thermal imaging results from dogs with palpable mammary nodules against a control group, focusing on capturing real-time thermal patterns. Results were significant, showing distinct thermal patterns in carcinomas. This indicates videothermometry’s capability in accurately identifying micro metastases and differentiating between neoplastic and non-neoplastic changes. The study concludes that videothermometry has considerable potential in enhancing surgical precision, especially in tumor resection and safety margin definition, but emphasizes the need for further research to thoroughly understand the thermal signatures of various mammary tumors in dogs. videothermometrys s indepth. indepth depth. depth in-depth group realtime real time significant carcinomas nonneoplastic non changes precision definition

ABSTRACT Models for athlete development have prioritized sports experiences, including events. It is assumed that the variety of events instills in the experience of paradoxical situations, important in the permanence in sport and/or active life. This article discusses the lived experience perception by children in two gymnastics for all events with different biases: one competitive and the other demonstrative. Based on qualitative research, 29 children were interviewed using Focus Groups (n=8), and data analysis using Thematic Analysis. Furthermore, field notes by 4 coaches and reflective narrative from the Focus Group interviewer were considered for triangulation. Two themes were highlighted: a. intersubjective aspects and b. interrelationships. These themes were addressed in both events to a greater or lesser extent. In item a, commitment, aesthetic components, and anxiety were in both events, but overcoming and nervousness more prominent in the competition. In item b, the importance of the other/ group was evident, mostly because of the presentation than the type of event. Recognizing the sporting bias of a practice is, therefore, promoting events of different natures, as practitioners can presume high performance or an active life through sport. experiences situations andor biases demonstrative research 2 n=8, n8 n n=8 , 8 (n=8) Analysis Furthermore triangulation highlighted b interrelationships extent commitment components competition evident event therefore natures n= (n=8 (n= (n

RESUMO Modelos de formação de atletas primam pela ampliação de experiências esportivas, incluindo os eventos esportivos. Assume-se que a variabilidade de propostas incute na vivência de situações paradoxais, importantes na permanência no esporte e/ou vida ativa. Este trabalho discute a percepção da experiência vivida em dois eventos de ginástica para todos com distintos vieses: um com caráter competitivo e outro com caráter demonstrativo. Protagonizaram o estudo 29 crianças participantes de um projeto de extensão universitária. Para a coleta de dados, realizaram-se 8 Grupos Focais, sendo utilizada a Análise Temática. Diários de campo e texto reflexivo do mediador dos GF foram considerados para a triangulação dos dados. Dois eixos foram evidenciados em ambos os eventos: a) aspectos intersubjetivos, cujo comprometimento, o componente estético e a ansiedade perpassaram ambos os eventos e a superação e o nervosismo tiveram maior destaque na competição; e b) inter-relações pessoais, nas quais a importância do outro/grupo foi evidente, com maior relação ao tipo de apresentação coreográfica de grupo, do que especificamente ao tipo de evento. Reconhece-se, então, o fomento a eventos de diferentes naturezas, uma vez que os praticantes de base podem presumir o alto rendimento ou a vida ativa pelo esporte. esportivas esportivos Assumese Assume se paradoxais eou vieses demonstrativo 2 universitária dados realizaramse realizaram Focais Temática intersubjetivos comprometimento competição b interrelações inter relações pessoais outrogrupo grupo evidente evento Reconhecese, Reconhecese Reconhece se, Reconhece-se então naturezas

Abstract A simple, rapid, precise, accurate and sustainable spectrofluorimetric method (SFM) was developed, validated and applied for the determination of 4-aminobenzoic acid and aromatic amino acids (phenylalanine, tryptophan and tyrosine). These compounds are used in biopharmaceutical formulations and therefore must be analyzed by quality control laboratories to meet the criteria established in pharmacopoeias. In general, potentiometric titration (PT) is described in the compendia as the official analytical technique. However, this method showed low sensitivity and selectivity, and moreover was performed with a non-aqueous solvent (acetic acid), which led to higher consumption of reagents and consequently to the formation of residues. Therefore, the SFM was developed in aqueous medium at pH 7.2 using phosphate buffer. It was successfully validated according to the ICH guidelines and showed good linearity range (r>0.999), specificity, accuracy and precision (within and between days) and robustness. The test results were compared between the SFM and PT using raw material samples, while according to the F- and t-tests at 95% confidence level, no statistical difference was found between the methods. simple rapid precise (SFM 4aminobenzoic aminobenzoic 4 phenylalanine, phenylalanine (phenylalanine tyrosine. tyrosine . tyrosine) pharmacopoeias general (PT technique However selectivity nonaqueous non acetic acid, , acid) residues Therefore 72 7 2 7. buffer r>0.999, r0999 r r>0.999 0 999 (r>0.999) specificity within days robustness samples F ttests t tests 95 level methods r099 r>0.99 99 (r>0.999 9 r09 r>0.9 (r>0.99 r0 r>0. (r>0.9 r>0 (r>0. r> (r>0 (r> (r

The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magneticresonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic. Morinda Linn. Linn antiviral anti viral procedure derivative 303 30 3 30. 307 7 30.7 respectively mice proinflammatory pro inflammatory effect antiinflammatory vitro replication cytotoxic

Abstract Glioblastoma multiforme is a tumor of the central nervous system. Focal Adhesion Kinase (FAK) and αB-crystalline are two proteins involved in glioblastoma development. In this study, we investigated whether the FAK/αB-crystalline interaction is important for glioblastoma cells, we aimed to investigate the interaction of these two proteins in the glioblastoma multiforme cell line U87-MG. Two peptides named FP01 peptide (derived from αB-crystalline) and FP02 peptide (derived from FAK) were synthesized for this study. Treatment of U87-MG with the peptides FP01 and FP02 in the concentration at 50 µM reduced the viability cellular to around 41% and 51%, respectively. Morphological alterations in the cells treated with the peptides when compared to the control were observed. This study suggests that the interaction between FAK and αB-crystalline is important for the viability of glioblastoma cells. system (FAK αBcrystalline αB crystalline development FAK/αBcrystalline FAKαBcrystalline FAK/αB U87MG. U87MG UMG U87 MG. MG U FP FP0 derived 5 41 51 51% respectively observed FAKαB U8 4